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https://www.readbyqxmd.com/read/29679518/new-insights-in-the-use-of-pleural-ultrasonography-for-diagnosis-and-treatment-of-pleural-disease
#1
Giampietro Marchetti, Sabrina Arondi, Francesca Baglivo, Sara Lonni, Federico Quadri, Alberto Valsecchi, Nicola Venturoli, Paolo Ceruti
The use of transthoracic ultrasound has acquired a wide consensus among respiratory physicians during the last few years. The developing of portable and easily available devices favorites patient's bedside evaluation. Transthoracic ultrasound provides rapid, real-time and low-cost diagnostic information, allowing image-guided chest interventions and reducing procedural risks. The different acoustic impedance between aerated and not aerated organs produces artifacts known as A lines, B lines, sliding sign, lung point, etc...
April 21, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29679363/proangiogenic-and-profibrotic-markers-in-pulmonary-sarcoidosis
#2
I Tuleta, L Biener, C Pizarro, G Nickenig, D Skowasch
The aim of our study was to determine the blood levels of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, fibroblast growth factor (FGF)-2, and platelet-derived growth factor (PDGF)-AB in different stages of pulmonary sarcoidosis. There were 92 patients in sarcoidosis stages I + II, III, and IV enrolled into the study. All the patients underwent lung diffusing capacity and blood sampling. We found that VEGF levels differed significantly between the stage groups with the peak VEGF concentrations in stage III...
April 21, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29678740/effects-of-pasteurella-multocida-lipopolysaccharides-on-bovine-leukocytes
#3
Sivakumar Periasamy, P Ezhil Praveena, Nem Singh
Lipopolysaccharide (LPS) is a major virulence factor of Gram-negative bacteria playing a major role in stimulating protective immune response in mammalian host. However, in many gram-negative bacterial infections, LPS also elicits immunopathology by inducing excessive inflammatory changes. P. multocida (Pm), a gram-negative bacterium, causes acute lung inflammation and fatal septicemic disease in animals. However, the effects of Pm LPS on host cells are little known. In this study, LPS isolated from three different serotypes (B:2, A:1 and A:3) of Pm were individually tested in vitro to assess the response of bovine leukocytes...
April 17, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29678610/nrf2-protects-against-acute-lung-injury-and-inflammation-by-modulating-tlr4-and-akt-signaling
#4
Jia Yan, Jingjie Li, Lei Zhang, Yu Sun, Jue Jiang, Yan Huang, Hui Xu, Hong Jiang, Rong Hu
Lung injury, which is associated with systemic inflammatory responses, is a common problem with significant morbidity and mortality. Here, we examined the involvement of toll-like receptor 4 (TLR4) and nuclear factor erythroid 2-related factor 2 (Nrf2) on intestinal ischemia-reperfusion (I/R)-induced lung injury in vivo and in vitro. Analysis of lung tissues in Nrf2-knockout mice by western blotting, immunohistochemistry, and TUNEL assay, and analysis of bronchoalveolar lavage fluid showed that Nrf2 deficiency upregulated TLR4, enhanced I/R-induced lung injury, apoptosis, inflammation, and autophagy, and increased the I/R-induced inactivation of Akt...
April 17, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29677174/the-role-of-autophagy-and-the-chemokine-c-x-c-motif-ligand-16-during-acute-lung-injury-in-mice
#5
Ye Gao, Ni Wang, Rui H Li, Yang Z Xiao
BACKGROUND Acute lung injury (ALI) is responsible for mortality in hospitalized patients. Autophagy can negatively regulate inflammatory response, and CXCL16 (chemokine (C-X-C motif) ligand 16) is a kind of chemokine, which is closely related to the inflammatory response. However, the relationship between autophagy and CXCL16 in ALI is still unclear. This study aimed to investigate the role of autophagy and chemokine CXCL16 in ALI in mice. MATERIAL AND METHODS Thirty-two male C57BL/6 mice were divided into four groups...
April 20, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29676834/working-while-unwell-workplace-impairment-in-people-with-severe-asthma
#6
Sarah A Hiles, Erin S Harvey, Vanessa M McDonald, Matthew Peters, Philip Bardin, Paul N Reynolds, John W Upham, Melissa Baraket, Zaheerodin Bhikoo, Jeffrey Bowden, Ben Brockway, Li Ping Chung, Belinda Cochrane, Gloria Foxley, Jeffrey Garrett, Mark Hew, Lata Jayaram, Christine Jenkins, Constance Katelaris, Gregory Katsoulotos, Mariko S Koh, Vicky Kritikos, Marina Lambert, David Langton, Alexis Lara Rivero, Guy B Marks, Peter G Middleton, Aldoph Nanguzgambo, Naghmeh Radhakrishna, Helen Reddel, Janet Rimmer, Anne Marie Southcott, Michael Sutherland, Francis Thien, Peter Ab Wark, Ian A Yang, Elaine Yap, Peter G Gibson
BACKGROUND: Severe asthma affects quality of life; however, its impact on workplace productivity is poorly understood. OBJECTIVE: To compare workplace productivity - absenteeism and presenteeism - and impairment in daily activities in severe and non-severe asthma over time and identify characteristics associated with presenteeism in severe asthma. METHODS: The Severe Asthma Web-based Database (SAWD) is an ongoing observational registry from Australia, New Zealand and Singapore...
April 20, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29676829/er-stress-mediated-autophagy-protects-against-%C3%AE-%C3%AE-dimethylacrylshikonin-induced-apoptosis-in-lung-adenocarcinoma-cells
#7
Haibing Wang, Gaochenxi Zhang
β,β-Dimethylacrylshikonin (DMAS) is an anti-cancer compound extracted from the roots of Lithospermum erythrorhizon. This study aims to investigate the effects of DMAS on human lung adenocarcinoma cells in vitro and explored the mechanisms of its anti-cancer action. We demonstrated that DMAS markedly inhibited cell viability in a dose- and time-dependent manner, and induced apoptosis as well as autophagy in human lung adenocarcinoma cells. Furthermore, we found that DMAS stimulated endoplasmic reticulum (ER) stress and mediated autophagy via the PERK-eIF2α-ATF4-CHOP and IRE1-TRAF2-JNK axises of the unfolded protein response (UPR) in human lung adenocarcinoma cells...
April 20, 2018: Cancer Science
https://www.readbyqxmd.com/read/29676646/ambient-air-pollution-and-clinical-implications-for-susceptible-populations
#8
Laura G Hooper, Joel D Kaufman
Air pollution is associated with a diversity of health effects, and evidence for a causal relationship with specific diseases exists. Exposure to air pollution is ubiquitous and typically beyond the control of the individual; the resulting health burden for the population can be high. Disproportionate effects are seen in individuals who have increased susceptibility to air pollution owing to individual- or community-level characteristics. As studies grow increasingly sophisticated, the understanding of who comprises the susceptible population continuously expands...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676644/air-pollution-exposure-with-fine-dust-responses-in-the-pulmonary-vasculature-and-the-right-heart
#9
Nedim Durmus, Gabriele Grunig
Detrimental effects of air pollution with fine dust (particulate matter ≤2.5 μm in aerodynamic diameter, or PM2.5 ) on the systemic circulation and the left heart have been studied intensely during the past decade. In comparison, knowledge regarding the effects of exposure to air pollution with PM2.5 on the pulmonary vasculature and the right heart lags far behind. A report on severe lung disease and right heart failure in coal miners was published nearly 170 years ago. However, today, we still do not have a clear picture of how the effect of air pollution on the pulmonary circulation or the right heart should be viewed from a clinical, mechanistic biological, therapeutic, or economic angle...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676630/international-approach-to-environmental-and-lung-health-a-perspective-from-the-fogarty-international-center
#10
Roger I Glass, Joshua P Rosenthal
The global burden of lung disease is substantial, accounting for an estimated 7.5 million deaths per year, approximately 14% of annual deaths worldwide. The prime illnesses include, in descending order, chronic obstructive pulmonary disease, lung cancer, tuberculosis, acute respiratory infections, asthma, and interstitial lung fibrosis. Key risk factors include smoking, both indoor and outdoor air pollution, and occupational exposures. Although the distribution of both the diseases and the risk factors varies greatly by age, geography, and setting, the greatest burden falls on populations living in low- and middle-income countries...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29676537/recovery-of-pulmonary-functions-exercise-capacity-and-quality-of-life-after-pulmonary-rehabilitation-in-survivors-of-ards-due-to-severe-influenza-a-h1n1-pneumonitis
#11
Meng-Jer Hsieh, Wei-Juen Lee, Hsiu-Ying Cho, Meng-Fang Wu, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Ying-Huang Tsai, Chung-Chi Huang
BACKGROUND: Acute respiratory distress syndrome (ARDS) due to severe influenza A H1N1 pneumonitis would result in impaired pulmonary functions and health-related quality of life (HRQoL) after hospital discharge. OBJECTIVES: The recovery of pulmonary functions, exercise capacity and HRQoL in the survivors of ARDS due to 2009 pandemic influenza A H1N1 pneumonitis (H1N1-ARDS) were evaluated in a tertiary teaching hospital in the northern Taiwan between May 2010 and June 2011...
April 20, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29676014/autoinflammatory-disease-in-the-lung
#12
REVIEW
Thomas Scambler, Jonathan Holbrook, Sinisa Savic, Michael F McDermott, Daniel Peckham
Ascertaining the dominant cell type driving an immunological disease is essential to understanding the causal pathology and, therefore, selecting or developing an effective treatment. Classifying immunological diseases in this way has led to successful treatment regimens for many monogenic diseases; however, when the dominant cell type is unclear and there is no obvious causal genetic mutation, then identifying the correct disease classification and appropriate therapy can be challenging. In this review we focus on pulmonary immunological diseases where an innate immune signature has been identified as a predominant aspect of the immunopathology...
April 19, 2018: Immunology
https://www.readbyqxmd.com/read/29675827/significant-increase-of-lymphatic-vessels-in-pleuroparenchymal-fibroelastosis
#13
Yoshiaki Kinoshita, Kentaro Watanabe, Hiroshi Ishii, Hisako Kushima, Masaki Fujita, Kazuki Nabeshima
AIMS: Some investigators have detected fibrinous exudate or immature organization in the alveolar spaces prior to the development of subpleural elastofibrosis in patients with pleuroparenchymal fibroelastosis (PPFE). We hypothesized that PPFE progress is associated with an impaired lymphatic drainage system, resulting in the failed resolution of intra-alveolar exudate. METHODS AND RESULTS: We retrospectively reviewed our medical records from 1995 to 2017 and selected autopsied or surgically biopsied patients with PPFE (n=18), pulmonary apical cap (n=18), and idiopathic pulmonary fibrosis (IPF) (n=26)...
April 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29675804/lactobacillus-plantarum-displaying-conserved-m2e-and-ha2-fusion-antigens-induces-protection-against-influenza-virus-challenge
#14
Wen-Tao Yang, Gui-Lian Yang, Liang Zhao, Yu-Bei Jin, Yan-Long Jiang, Hai-Bin Huang, Chun-Wei Shi, Jian-Zhong Wang, Guan Wang, Yuan-Huan Kang, Chun-Feng Wang
Avian influenza virus (AIV) can infect poultry, mammals, and other hosts and causes enormous economic losses to the global poultry industry. In this study, to develop a novel and potent oral vaccine based on Lactobacillus plantarum (L. plantarum) for controlling the spread of AIV in the poultry industry, we constructed a recombinant L. plantarum strain displaying the 3M2e-HA2 protein of the influenza virus and determined the effect of N/pgsA'-3M2e-HA2 against AIV in chicks. We first confirmed that the 3M2e-HA2 fusion protein was expressed on the surface of L...
April 19, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29674691/aloperine-protects-mice-against-bleomycin-induced-pulmonary-fibrosis-by-attenuating-fibroblast-proliferation-and-differentiation
#15
Wanling Yin, Jing Han, Zhijun Zhang, Zaomu Han, Siyuan Wang
Aloperine is a quinolizidine alkaloid extracted from Sophora alopecuroides. It has been proven to alleviate oxidative stress and effectively promote tumor cell apoptosis in mice. Herein, we investigated whether aloperine could also mediate its protective effects on bleomycin (BLM)-induced pulmonary fibrosis. Pathological staining, western blot, RT-PCR and flow cytometry were used to evaluate the impact of aloperine on the development of pulmonary fibrosis. The effect of aloperine on fibroblast proliferation, differentiation and related signaling pathways were next investigated to demonstrate the underlying mechanisms...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29674424/utilizing-radiolabeled-3-deoxy-3-18-f-fluorothymidine-with-positron-emission-tomography-to-monitor-the-effect-of-dexamethasone-on-non-small-cell-lung-cancer
#16
Christopher McHugh, Monica R Thipparthi, Jawana M Lawhorn-Crews, Lisa Polin, Shirish Gadgeel, Janice Akoury, Thomas J Mangner, Kirk A Douglas, Jing Li, Manohar Ratnam, Anthony F Shields
Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality in the United States and pemetrexed-based therapies are regularly used to treat non-squamous NSCLC. Despite widespread use, pemetrexed has a modest effect on progression-free survival, with varying efficacy between individuals. Recent work has indicated that dexamethasone, given to prevent pemetrexed toxicity, is able to protect a subset of NSCLC cells from pemetrexed cytotoxicity by temporarily suppressing of the S-phase of the cell cycle...
April 19, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29674276/protective-effects-of-radish-raphanus-sativus-l-leaves-extract-against-hydrogen-peroxide-induced-oxidative-damage-in-human-fetal-lung-fibroblast-mrc-5-cells
#17
Xiaoping Luo, Haihui Zhang, Yuqing Duan, Guangying Chen
Natural antioxidants play a critical role in the promotion of good health for its prevention of oxidative stress. The main purpose of this study is to investigate the protective effects of radish leaves extract on the oxidative damage in human fetal lung fibroblast (MRC-5) cells. F2, a fraction of radish leaves extracts, which was fractionated by different polarity solvents and AB-8 macroporous resins column shows the best free radical scavenging ability, the highest total polyphenol contents (TPC), and the most potent protective effects on H2 O2 -induced oxidative damage in MRC-5 cells...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29673335/dietary-patterns-bcmo1-polymorphisms-and-primary-lung-cancer-risk-in-a-han-chinese-population-a-case-control-study-in-southeast-china
#18
Fei He, Ren-Dong Xiao, Tao Lin, Wei-Min Xiong, Qiu-Ping Xu, Xu Li, Zhi-Qiang Liu, Bao-Chang He, Zhi-Jian Hu, Lin Cai
BACKGROUND: We investigated whether BCMO1 variants and dietary patterns are associated with lung cancer risk. METHODS: Case-control study including 1166 lung cancer cases and 1179 frequency matched controls was conducted for three BCMO1 variants (rs6564851, rs12934922, and rs7501331) and four dietary patterns were investigated. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). RESULTS: The rs6564851, rs12934922, and rs7501331 were not found to be associated with lung cancer risk (P > 0...
April 19, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29673286/inhibition-of-autophagy-with-3-methyladenine-is-protective-in-a-lethal-model-of-murine-endotoxemia-and-polymicrobial-sepsis
#19
Qirui Li, Lingyun Li, Xiaoyuan Fei, Yuanyue Zhang, Chang Qi, Shuyao Hua, Feili Gong, Min Fang
Here, the regulatory role of autophagy is examined in both an LPS-induced lethal endotoxic shock mouse model and cecal ligation and puncture (CLP) mouse model. Autophagy-inhibitor 3-methyladenine (3-MA) and autophagy-enhancer rapamycin were administrated to mice challenged with LPS or CLP. Animals challenged with LPS or CLP combined with 3-MA displayed increased survival after endotoxemia, but LPS combined with rapamycin worsened the endotoxic shock of the mice. Among the different organs studied, the lungs and intestines exhibited significant differences among LPS alone, LPS combined with 3-MA and LPS combined with rapamycin...
January 1, 2018: Innate Immunity
https://www.readbyqxmd.com/read/29673099/heart-and-lung-organ-offer-acceptance-practices-of-transplant-programs-are-associated-with-waitlist-mortality-and-organ-yield
#20
Andrew Wey, Maryam Valapour, Melissa A Skeans, Nicholas Salkowski, Monica Colvin, Bertram L Kasiske, Ajay K Israni, Jon J Snyder
Variation in heart and lung offer acceptance practices may affect numbers of transplanted organs and create variability in waitlist mortality. To investigate these issues, offer acceptance ratios, or adjusted odds ratios, for heart and lung transplant programs individually and for all programs within donation service areas (DSAs) were estimated using offers from donors recovered July 1, 2016-June 30, 2017. Logistic regressions estimated the association of DSA-level offer acceptance ratios with donor yield and local placement of organs recovered in the DSA...
April 19, 2018: American Journal of Transplantation
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