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https://www.readbyqxmd.com/read/29674978/reporter-based-isolation-of-developmental-myogenic-progenitors
#1
Eyemen Kheir, Gabriella Cusella, Graziella Messina, Giulio Cossu, Stefano Biressi
The formation and activity of mammalian tissues entail finely regulated processes, involving the concerted organization and interaction of multiple cell types. In recent years the prospective isolation of distinct progenitor and stem cell populations has become a powerful tool in the hands of developmental biologists and has rendered the investigation of their intrinsic properties possible. In this protocol, we describe how to purify progenitors with different lineage history and degree of differentiation from embryonic and fetal skeletal muscle by fluorescence-activated cell sorting (FACS)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29674451/fully-reduced-hmgb1-accelerates-the-regeneration-of-multiple-tissues-by-transitioning-stem-cells-to-g-alert
#2
Geoffrey Lee, Ana Isabel Espirito Santo, Stefan Zwingenberger, Lawrence Cai, Thomas Vogl, Marc Feldmann, Nicole J Horwood, James K Chan, Jagdeep Nanchahal
A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Injury leads to the release of danger signals which are known to modulate the immune response, but their role in stem cell-mediated repair in vivo remains to be clarified...
April 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29674431/cell-type-transcriptome-atlas-for-the-planarian-schmidtea-mediterranea
#3
Christopher T Fincher, Omri Wurtzel, Thom de Hoog, Kellie M Kravarik, Peter W Reddien
The transcriptome of a cell dictates its unique cell-type biology. We used single-cell RNA sequencing to determine the transcriptomes for essentially every cell type of a complete animal: the regenerative planarian Schmidtea mediterranea. Planarians contain a diverse array of cell types, possess lineage progenitors for differentiated cells (including pluripotent stem cells), and constitutively express positional information, making them ideal for this undertaking. We generated data for 66,783 cells, defining transcriptomes for known and many previously unknown planarian cell types and for putative transition states between stem and differentiated cells...
April 19, 2018: Science
https://www.readbyqxmd.com/read/29674282/bioenergetics-mechanisms-regulating-muscle-stem-cell-self-renewal-commitment-and-function
#4
REVIEW
Phablo Abreu
Muscle stem cells or satellite cells are crucial for muscle maintenance and repair. These cells are mitotically quiescent and uniformly express the transcription factor Pax7, intermittently entering the cell cycle to give rise to daughter myogenic precursors cells and fuse with neighboring myofibers or self-renew, replenishing the stem cell pool in adult skeletal muscle. Pivotal roles of muscle stem cells in muscle repair have been uncovered, but it still remains unclear how muscle stem cell self-renewal is molecularly regulated and how muscle stem cells maintain muscle tissue homeostasis...
April 16, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29674052/glycan-affinity-magnetic-nanoplatforms-for-urinary-glycobiomarkers-discovery-in-bladder-cancer
#5
Rita Azevedo, Janine Soares, Cristiana Gaiteiro, Andreia Peixoto, Luís Lima, Dylan Ferreira, Marta Relvas-Santos, Elisabete Fernandes, Ana Tavares, Sofia Cotton, Ana Luísa Daniel-da-Silva, Lúcio Lara Santos, Rui Vitorino, Francisco Amado, José Alexandre Ferreira
Bladder Cancer (BC) presents one of the highest recurrence rates amongst solid tumours and constitutes the second deadliest disease of the genitourinary track. Non-invasive identification of patients facing disease recurrence and/or progression remains one of the most critical and challenging aspects in disease management. To contribute to this goal, we demonstrate the potential of glycan-affinity glycoproteomics nanoplatforms for urinary biomarkers discovery in bladder cancer. Briefly, magnetic nanoprobes (MNP) coated with three broad-spectrum lectins, namely Concanavalin A (ConA; MNP@ConA), Wheat Germ Agglutinin (WGA; MNP@WGA), and Sambucus nigra (SNA; MNP@SNA), were used to selectively capture glycoproteins from the urine of low-grade and high-grade non-muscle invasive as well as muscle-invasive BC patients...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29670077/induction-of-muscle-stem-cell-quiescence-by-the-secreted-niche-factor-oncostatin-m
#6
Srinath C Sampath, Srihari C Sampath, Andrew T V Ho, Stéphane Y Corbel, Joshua D Millstone, John Lamb, John Walker, Bernd Kinzel, Christian Schmedt, Helen M Blau
The balance between stem cell quiescence and proliferation in skeletal muscle is tightly controlled, but perturbed in a variety of disease states. Despite progress in identifying activators of stem cell proliferation, the niche factor(s) responsible for quiescence induction remain unclear. Here we report an in vivo imaging-based screen which identifies Oncostatin M (OSM), a member of the interleukin-6 family of cytokines, as a potent inducer of muscle stem cell (MuSC, satellite cell) quiescence. OSM is produced by muscle fibers, induces reversible MuSC cell cycle exit, and maintains stem cell regenerative capacity as judged by serial transplantation...
April 18, 2018: Nature Communications
https://www.readbyqxmd.com/read/29669293/three-dimensional-human-ipsc-derived-artificial-skeletal-muscles-model-muscular-dystrophies-and-enable-multilineage-tissue-engineering
#7
Sara Martina Maffioletti, Shilpita Sarcar, Alexander B H Henderson, Ingra Mannhardt, Luca Pinton, Louise Anne Moyle, Heather Steele-Stallard, Ornella Cappellari, Kim E Wells, Giulia Ferrari, Jamie S Mitchell, Giulia E Tyzack, Vassilios N Kotiadis, Moustafa Khedr, Martina Ragazzi, Weixin Wang, Michael R Duchen, Rickie Patani, Peter S Zammit, Dominic J Wells, Thomas Eschenhagen, Francesco Saverio Tedesco
Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional (3D) artificial skeletal muscle tissue from human pluripotent stem cells, including induced pluripotent stem cells (iPSCs) from patients with Duchenne, limb-girdle, and congenital muscular dystrophies. 3D skeletal myogenic differentiation of pluripotent cells was induced within hydrogels under tension to provide myofiber alignment. Artificial muscles recapitulated characteristics of human skeletal muscle tissue and could be implanted into immunodeficient mice...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29668776/muscle-regeneration-through-therapy-with-estromal-stem-cells-in-injury-of-infraespinhosus-muscle-of-sheep
#8
Aline Grama Moreira Brandão, Angélica Consalter, Juliana da Silva Leite, Helia Zamprogno, Ana Maria Reis Ferreira
PURPOSE: To evaluate the effects of rotator cuff muscle regeneration in sheep and establish an experimental model for the use of autologous stem cells as a treatment option for tendon injuries. METHODS: Infrared muscle tenotomies and Penrose drain implantation were performed on 12 shoulders of six clinically healthy adult sheep. After 60 days, the tendons were submitted to tissue repair, drainage removal, and divided into two groups according to the use of autologous stromal stem cells for treatment...
March 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29666119/depot-specific-characteristics-of-adipose-tissue-derived-stromal-cells-in-thyroid-associated-orbitopathy
#9
Janice Siu Chong Wong, Wai Kit Chu, Benjamin Fuk-Loi Li, Chi-Pui Pang, Kelvin Kam-Lung Chong
BACKGROUND: Thyroid-associated orbitopathy (TAO) causes inflammatory fibroproliferation of periocular connective tissues. We compared adipose tissue-derived stem/stromal cells (ADSCs) from three adipose depots of each patient with TAO on mesenchymal, myofibrogenic, adipogenic properties and associated hyaluronan (HA) synthesis. METHODS: ADSCs were generated from periocular (eyelid, orbital) and subcutaneous (abdominal) adipose tissues of three patients with TAO...
April 17, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29664744/the-impact-of-aerobic-exercise-on-the-muscle-stem-cell-response
#10
Sophie Joanisse, Tim Snijders, Joshua P Nederveen, Gianni Parise
Satellite cells are indispensable for skeletal muscle repair and regeneration and are associated with muscle growth in humans. Aerobic exercise training results in improved skeletal muscle health also translating to an increase in satellite cell pool activation. We postulate that aerobic exercise improves satellite cell function in skeletal muscle.
April 16, 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29662491/regulatory-t-cells-potential-regulator-of-tissue-repair-and-regeneration
#11
REVIEW
Jiatao Li, Jean Tan, Mikaël M Martino, Kathy O Lui
The identification of stem cells and growth factors as well as the development of biomaterials hold great promise for regenerative medicine applications. However, the therapeutic efficacy of regenerative therapies can be greatly influenced by the host immune system, which plays a pivotal role during tissue repair and regeneration. Therefore, understanding how the immune system modulates tissue healing is critical to design efficient regenerative strategies. While the innate immune system is well known to be involved in the tissue healing process, the adaptive immune system has recently emerged as a key player...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29660398/molecular-phenotypes-of-the-human-kidney-myoid-stromal-cells-telocytes-and-myoepithelial-cells
#12
M C Rusu, L Mogoantă, F Pop, M A Dobra
The connective stromal and epithelial compartments of the kidney have regenerative potential and phenotypic flexibility. A few studies have shown that cells appertaining to both compartments can exhibit myoid phenotypes. The purpose of our study was to investigate the myoid pattern of kidney and its association with the kidney niches containing stromal cells/telocytes (SC/TCs). We performed an immunohistochemical study using a panel of endothelial, myoid, mesenchymal and stem/progenitor markers, namely CD31, CD34, CD105 (endoglin), CD117/c-kit, nestin, desmin, α-smooth muscle actin (α-SMA) and the heavy chain of smooth muscle myosin (SMM)...
April 13, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29659518/examining-the-genetic-background-of-porcine-muscle-growth-and-development-based-on-transcriptome-and-mirnaome-data
#13
Katarzyna Ropka-Molik, Klaudia Pawlina-Tyszko, Kacper Żukowski, Katarzyna Piórkowska, Grzegorz Żak, Artur Gurgul, Natalia Derebecka, Joanna Wesoły
Recently, selection in pigs has been focused on improving the lean meat content in carcasses; this focus has been most evident in breeds constituting a paternal component in breeding. Such sire-breeds are used to improve the meat quantity of cross-breed pig lines. However, even in one breed, a significant variation in the meatiness level can be observed. In the present study, the comprehensive analysis of genes and microRNA expression profiles in porcine muscle tissue was applied to identify the genetic background of meat content...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29659307/recent-advances-in-ultrasound-triggered-therapy
#14
Chaopin Yang, Yue Li, Meng Du, Zhiyi Chen
As a non-invasive and real-time diagnostic technique, ultrasound has provided a novel strategy for targeted treatment. With the rapid development of ultrasonic technique and ultrasound contrast agents (UCAs), spatiotemporally controllable application of ultrasound with or without UCAs makes it possible for site-specific delivery of therapeutic agents and targeted modulation with minimal side effects, which indicated a promising therapy in clinical use. This review will describe the main mechanism of targeted therapy induced by ultrasound briefly, then focus on the current application of ultrasound mediated targeted therapy in various fields including tumor, cardiovascular disease, central nervous system, skeletal muscle system diseases and stem cells therapy...
April 16, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29659159/spinal-accessory-motor-neurons-in-the-mouse-a-special-type-of-branchial-motor-neuron
#15
Charles Watson, Petr Tvrdik
The spinal accessory nerve arises from motor neurons in the upper cervical spinal cord. The axons of these motor neurons exit dorsal to the ligamentum denticulatum and form the spinal accessory nerve. The nerve ascends in the spinal subarachnoid space to enter the posterior cranial fossa through the foramen magnum. The spinal accessory nerve then turns caudally to exit through the jugular foramen alongside the vagus and glossopharyngeal nerves, and then travels to supply the sternomastoid and trapezius muscles in the neck...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29658391/tgf%C3%AE-1-promotes-breast-cancer-local-invasion-and-liver-metastasis-by-increasing-the-cd44-high-cd24-subpopulation
#16
Chenjing Zhang, Huiqin Gao, Chao Li, Jiangfeng Tu, Zhihao Chen, Weiwei Su, Xiaoge Geng, Xiaojun Chen, Jingya Wang, Wensheng Pan
OBJECTIVE: Previous studies have shown that the transforming growth factor β1 pathway plays an important role in breast cancer metastasis to the liver. However, the mechanism of this metastasis has not been fully clarified. Cancer stem cells are essential for the initiation and propagation of tumor metastasis. The objective of our current study was to define the role of cancer stem cells in transforming growth factor β1-mediated breast cancer hepatic metastases. METHOD: Hematoxylin and eosin staining was used to assess the formation of breast cancer liver metastases and local invasion...
January 1, 2018: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29657936/cellular-therapy-for-chronic-traumatic-brachial-plexus-injury
#17
Alok Sharma, Hemangi Sane, Nandini Gokulchandran, Prerna Badhe, Suhasini Pai, Pooja Kulkarni, Jayanti Yadav, Sanket Inamdar
Cellular therapy is being actively pursued as a therapeutic modality in many of the neurological diseases. A variety of stem cells from diverse sources have been studied in detail and have been shown to exhibit angiogenetic and immunomodulatory properties in addition to other neuroprotective effects. Published clinical data have shown bone marrow mononuclear cell (BMMNC) injection in neurological disorders is safe and possesses regenerative potential. We illustrate a case of 27-year-old male with traumatic brachial plexus injury, administered with autologous BMMNCs intrathecally and intramuscularly, followed by multidisciplinary rehabilitation...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29653394/generation-of-duchenne-muscular-dystrophy-patient-specific-induced-pluripotent-stem-cell-line-lacking-exons-45-50-of-the-dystrophin-gene-iiti001-a
#18
Binyamin Eisen, Ronen Ben Jehuda, Ashley J Cuttitta, Lucy N Mekies, Irina Reiter, Sindhu Ramchandren, Michael Arad, Daniel E Michele, Ofer Binah
Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle degenerative disease caused by mutations in the dystrophin gene. We generated induced pluripotent stem cells (iPSCs) from a 13-year-old male patient carrying a deletion mutation of exons 45-50; iPSCs were subsequently differentiated into cardiomyocytes. iPSCs exhibit expression of the pluripotent markers (SOX2, NANOG, OCT4), differentiation capacity into the three germ layers, normal karyotype, genetic identity to the skin biopsy dermal fibroblasts and the patient-specific dystrophin mutation...
April 3, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29652869/effect-of-sustained-hypoxia-on-autophagy-of-genioglossus-muscle-derived-stem-cells
#19
Dongsheng Zhang, Shanshan Jia, Hengkun Wang, Shengyun Huang, Lili Xiao, Li Ma, Guangping Liu, Kun Gong, Le Xu
BACKGROUND Previous studies have demonstrated that sustained hypoxia in people with obstructive sleep apnea (OSA) impairs upper airway muscle activity, but the underlying mechanism remains poorly understood. As autophagy acts as an important regulator under hypoxia stress, we performed an in vitro investigation of the effects of sustained hypoxia on autophagy of genioglossus muscle-derived stem cells (GG MDSC), an important component of the upper airway muscle. MATERIAL AND METHODS Genioglossus MDSCs were obtained from Sprague-Dawley (SD) rats and identified by using immunofluorescence staining for CD34, Sca-1, and desmin...
April 13, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29652595/stem-cells-for-skeletal-muscle-tissue-engineering
#20
Molly N Pantellic, Lisa Marie Larkin
Volumetric muscle loss (VML) is a debilitating condition wherein muscle loss overwhelms the body's normal physiological repair mechanism. VML is particularly common among military service members who have sustained war injuries. Because of the high social and medical cost associated with VML and suboptimal current surgical treatments, there is great interest in developing better VML therapies. Skeletal muscle tissue engineering (SMTE) is a promising alternative to traditional VML surgical treatments that use autogenic tissue grafts, and rather uses isolated stem cells with myogenic potential to generate de novo skeletal muscle tissues to treat VML...
March 14, 2018: Tissue Engineering. Part B, Reviews
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