keyword
https://read.qxmd.com/read/38449920/septic-arthritis-of-the-spinal-facet-joint-review-of-117-cases
#1
JOURNAL ARTICLE
John J Ross, Kevin L Ard
BACKGROUND: Septic arthritis of the spinal facet joints is increasingly recognized in the era of magnetic resonance imaging, but its epidemiology, clinical features, management, and prognosis are ill-defined. METHODS: We review 101 previously published cases and report 16 cases occurring at our institutions between 2006 and 2018. RESULTS: Most patients presented with fever (60%) and back or neck pain (86%). Radiation into the hip, buttock, or limb was present in 34%...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38449914/atypical-presentation-resembling-acute-leukoencephalopathy-with-restricted-diffusion-in-staphylococcus-aureus-meningoencephalitis
#2
Jai Ranjan, Arvinder Wander, Navdeep Kaur, Bhawna Sharma, Kamla Kant, Akriti Aggarwal
Meningoencephalitis refers to inflammation of the brain and meninges. It can be caused by various organisms, such as  Neisseria meningitidis ,  Streptococcus pneumoniae , and so on.  Staphylococcus aureus  causing meningoencephalitis is relatively rare. It is mainly encountered in patients who have undergone surgeries in the past. Acute leukoencephalopathy with restricted diffusion (ALERD) is a type of encephalopathy that can involve both white and grey matter of the brain, and it has a characteristic "bright tree appearance" on MRI...
March 2024: Curēus
https://read.qxmd.com/read/38401293/efficacy-of-prophylactic-use-of-intraoperative-vancomycin-powder-in-preventing-surgical-site-infection-in-neurological-surgeries-in-irrua-nigeria-a-randomized-controlled-study
#3
JOURNAL ARTICLE
E Morgan, J E Onuminya, C O Osime, B O Adebayo, O Ehioghae, B Adetunmbi
PURPOSE: The objective was to determine the efficacy of intraoperative vancomycin powder in preventing SSIs in neurological surgeries. METHODS: A prospective randomized controlled study of patients who had clean cranial and non-implant spine surgeries at the Irrua Specialist Teaching Hospital, Irrua, Nigeria from February 1, 2021 to January 31, 2022. Patients were randomized into two groups. Group A patients had prophylactic intraoperative vancomycin powder applied to the surgical bed before wound closure while group B patients did not...
February 23, 2024: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://read.qxmd.com/read/38380569/e-globulus-leaf-eo-exhibits-anti-inflammatory-effects-by-regulating-gsdmd-mediated-pyroptosis-thereby-alleviating-neurological-impairment-and-neuroinflammation-in-experimental-stroke-mice
#4
JOURNAL ARTICLE
Dexiao Wang, Zhengmei Shi, Chaojie Liu, Qian Wang, Heng Liu, Junli He, Hairong Zhao, Chenggui Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatic and medicinal plants continue to be a major component of alternative and traditional medicine in the developing countries. Eucalyptus globulus (Labill.) is being employed to cultivation and production in China. However, few studies have reported the chemical composition and anti-inflammatory activity of Eucalyptus globulus (Labill.) leaf essential oil (E. globulus leaf EO) extracted from Eucalyptus globulus. AIM OF THE STUDY: This study aimed to assess the composition of E...
January 30, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38336272/septic-arthritis-of-the-facet-joint-is-also-a-severe-vertebral-infection-a-multicenter-retrospective-study-of-65-patients
#5
JOURNAL ARTICLE
Cadiou Simon, Tuil Rachel, Le Goff Benoît, Hoppé Emmanuel, Mulleman Denis, Langbour Camille, Le Pabic Estelle, Charret Laurie, Cormier Helene, Lecomte Raphael, Arvieux Cédric, Guggenbuhl Pascal
OBJECTIVE: Septic arthritis of the Facet Joints (SAFJ) is a rare condition. Little data has been published on the subject. We aimed to describe the clinical, biological and imagery presentations, as well as the course of this rare infection. METHODS: We included patients hospitalized between January 1st , 2016 and December 31th , 2019, in the Departments of Infectious Diseases or Rheumatology in 5 French centres in the CRIOGO network. We defined septic arthritis according to Newman's criteria and facet joint arthritis using imagery...
February 7, 2024: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/38326360/antioxidant-antibacterial-and-molecular-docking-of-methyl-ferulate-and-oleic-acid-produced-by-aspergillus-pseudodeflectus-aumc-15761-utilizing-wheat-bran
#6
JOURNAL ARTICLE
Ahmed Mohamed Ahmed Ali Ramadan, Sabry Ahmed Hussein Zidan, Reda Mohamed Shehata, Hussein Hosny El-Sheikh, Fuad Ameen, Steven L Stephenson, Osama Abdel-Hafeez Mohamed Al-Bedak
Secondary metabolites (SMs) are the primary source of therapeutics and lead chemicals in medicine. They have been especially important in the creation of effective cures for conditions such as cancer, malaria, bacterial and fungal infections, neurological and cardiovascular problems, and autoimmune illnesses. In the present study, Aspergillus pseudodeflectus AUMC 15761 was demonstrated to use wheat bran in solid state fermentation (SSF) at optimum conditions (pH 7.0 at 30 °C after 10 days of incubation and using sodium nitrate as a nitrogen source) to produce methyl ferulate and oleic acid with significant antioxidant and antibacterial properties...
February 7, 2024: Scientific Reports
https://read.qxmd.com/read/38165875/a-prospective-observational-study-of-estimating-drug-related-problems-and-clinical-outcomes-in-subtypes-of-stroke-patients
#7
JOURNAL ARTICLE
Muhammad Ali, Muhammad Harris Shoaib, Shagufta Nesar, Muhammad Jamal, Sabiha Gul, Saira Shahnaz, Shoaib Nawaz, Quratulain Khan, Javaria Imran
BACKGROUND: Stroke is a neurological disease and a leading cause of mortality worldwide. Strokes mainly consist of two types: hemorrhage and ischemia. Stroke patients are being administered multiple drug therapy and are at risk of drug-related problems. AIM: To estimate drug-related problems (DRPs) and clinical end outcomes in hospitalized stroke patients. METHODS: Current study was a multicenter, cross-sectional prospective observational study including 250 stroke patients admitted to tertiary care hospitals in Karachi, Pakistan...
2024: PloS One
https://read.qxmd.com/read/38156541/-therapeutic-plasma-exchange-in-a-patient-with-chronic-hemodialysis-and-a-new-diagnosis-of-myasthenia-gravis
#8
A Giudicissi, D Vetrano, S Morresi, P F Bruno, L Neri, S Signorotti, V Sgarlato, M Ruggeri, F Zanchelli, M Longoni, A Buscaroli
Case Report C.S.T. (♂, 71 years old) is a patient with multiple and severe comorbidities, undergoing thrice-weekly chronic hemodialysis since 2008 due to the progression of post-lithiasic uropathy. Over the past 2 months, the patient had been experiencing progressive ptosis of the eyelids, muscle weakness, and ultimately dysphagia and dysarthria that emerged in the last few days. Urgently admitted to the Neurology department, electromyography (EMG) was performed, leading to a diagnosis of predominant cranial myasthenia gravis (with borderline anti-acetylcholine receptor antibody serology)...
December 22, 2023: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/38094199/crispr-cas9-mediated-somatic-correction-of-a-one-base-deletion-in-the-ugt1a-gene-ameliorates-hyperbilirubinemia-in-crigler-najjar-syndrome-mice
#9
JOURNAL ARTICLE
Giulia Bortolussi, Alessandra Iaconcig, Giulia Canarutto, Fabiola Porro, Filippo Ferrucci, Claudia Galletta, Cristian Díaz-Muñoz, Vipin Rawat, Alessia De Caneva, Olayemi Joseph Olajide, Lorena Zentilin, Silvano Piazza, Luka Bočkor, Andrés Fernando Muro
(AAV)-mediated episomal gene replacement therapy for monogenic liver disorders is currently limited in pediatric settings due to the loss of vector DNA, associated with hepatocyte duplication during liver growth. Genome editing is a promising strategy leading to a permanent and specific genome modification that is transmitted to daughter cells upon proliferation. Using genome targeting, we previously rescued neonatal lethality in mice with Crigler-Najjar syndrome. This rare monogenic disease is characterized by severe neonatal unconjugated hyperbilirubinemia, neurological damage, and death...
December 14, 2023: Molecular Therapy. Methods & Clinical Development
https://read.qxmd.com/read/38052193/incidence-and-management-of-hardware-related-wound-infections-in-spinal-cord-peripheral-nerve-field-and-deep-brain-stimulation-surgery-a-single-center-study
#10
JOURNAL ARTICLE
Ingeborg van Kroonenburgh, Sonny K H Tan, Petra Heiden, Jochen Wirths, Georgios Matis, Harald Seifert, Veerle Visser-Vandewalle, Pablo Andrade
INTRODUCTION: Neuromodulation using deep brain stimulation (DBS), spinal cord stimulation (SCS), and peripheral nerve field stimulation (PNFS) to treat neurological, psychiatric, and pain disorders is a rapidly growing field. Infections related to the implanted hardware are among the most common complications and result in health-related and economic burden. Unfortunately, conservative medical therapy is less likely to be successful. In this retrospective study, we aimed to identify characteristics of the infections and investigated surgical and antimicrobial treatments...
December 5, 2023: Stereotactic and Functional Neurosurgery
https://read.qxmd.com/read/38049637/optic-nerve-sheath-diameter-measurement-for-the-paediatric-patient-with-an-acute-deterioration-in-consciousness
#11
JOURNAL ARTICLE
Ahmed Ali, David J McCreary
Ocular Point of Care Ultrasound (PoCUS) is emerging as a valuable utility within emergency medicine. Optic nerve sheath diameter (ONSD) has been demonstrated to correlate closely with intracranial pressure (ICP) and an elevated measurement can detect raised ICP readily, where fundoscopy may not, owing to both technical challenges and insufficient clinical skills. A previously fit and well 10-year-old girl presented to the paediatric emergency department with worsening headache, fever and lethargy. On examination, her left pupil was large, and not reactive to light...
December 4, 2023: The ultrasound journal
https://read.qxmd.com/read/38008577/-antimicrobials-discovery-against-staphylococcus-aureus-by-high-throughput-screening-of-drug-library
#12
JOURNAL ARTICLE
P F She, Y F Yang, L H Li, L Y Zhou, Y Wu
To develop antimicrobials against Staphylococcus aureus by high throughput screening of drug library. The type of this study is experimental research. The clinical isolates of S. aureus were collected from the sputum samples of respiratory inpatient department of the Third Xiangya Hospital of Central South University. The anti-planktonic cells growth inhibition activity of FDA-approved drugs library (including 1 573 molecules) was assessed by building a planktonic cells screening platform; The biofilm inhibitory effect of the FDA-approved drugs was detected by building a biofilm screening platform combined with crystal violet staining; Minimal inhibitory concentrations of the selected hits were determined by broth microdilution assay...
November 6, 2023: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://read.qxmd.com/read/37980513/understanding-the-management-of-pediatric-spondylodiscitis-based-on-existing-literature-a-systematic-review
#13
JOURNAL ARTICLE
Narges Lashkarbolouk, Mahdi Mazandarani, Brice Ilharreborde, Mohammad Hossein Nabian
BACKGROUND: Spondylodiscitis (SD), a rare disease in children, poses diagnostic challenges due to non-specific presenting symptoms, scarcity in incidence, and difficulty expressing pain in non-verbal children. METHOD: A comprehensive search was conducted on three databases, including PubMed/Medline, Web of Science, and Scopus until March 2023. The inclusion criteria were studies that investigated the clinical characteristics, treatment, and complications of children's spondylodiscitis...
November 18, 2023: BMC Pediatrics
https://read.qxmd.com/read/37824362/evaluation-of-epidemiological-and-microbiological-characteristics-clinical-features-and-outcomes-of-adult-patients-with-infective-endocarditis-in-mashhad-iran
#14
JOURNAL ARTICLE
Ali Shahini, Matin Shirazinia, Raha Jafari, Ali Akbar Heydari
INTRODUCTION: Infective endocarditis (IE) is a serious problem with high morbidity and mortality. However, there is a paucity of data regarding its epidemiology in non-high-income settings. Here, we described the characteristics of patients with IE. METHODOLOGY: Between March 2012 to March 2020, all adults (≥ 16 years) with a diagnosis of IE who were admitted to a university hospital in Mashhad, Iran, were included in the study. RESULTS: We evaluated 46 cases of IE with a median age of 42 years (interquartile range 31 to 58...
September 30, 2023: Journal of Infection in Developing Countries
https://read.qxmd.com/read/37784062/predictive-models-for-sepsis-in-children-with-staphylococcus-aureus-bloodstream-infections-a-retrospective-cohort-study
#15
JOURNAL ARTICLE
Chen Sun, Dongdong Tan, Jiajia Yu, Jingxian Liu, Dihua Shen, Shuang Li, Shiyong Zhao, Liya Zhang, Huajun Li, Kang Cai, Shanshan Xu, Lisu Huang
BACKGROUND: The presence of Staphylococcus aureus in the bloodstream can lead to the development of sepsis; however, the severity and risk factors of the systemic inflammatory response to Staphylococcus aureus bloodstream infections were unclear. This study is aimed to build a model to predict the risk of sepsis in children with Staphylococcus aureus bloodstream infections. METHODS: A retrospective analysis of hospitalized pediatric patients diagnosed with Staphylococcus aureus bloodstream infections was performed between January 2013 and December 2019...
October 2, 2023: BMC Pediatrics
https://read.qxmd.com/read/37766913/frequency-clinical-characteristics-and-outcomes-of-pneumonia-in-patients-with-out-of-hospital-cardiac-arrest-undergoing-extracorporeal-cardiopulmonary-resuscitation
#16
JOURNAL ARTICLE
Eiki Iida, Nao Ichihara, Toru Hifumi, Kasumi Shirasaki, Katsuhiro Horie, Shutaro Isokawa, Akihiko Inoue, Tetsuya Sakamoto, Yasuhiro Kuroda, Norio Otani
AIM: This study aimed to describe the frequency, clinical characteristics, and outcomes of pneumonia in OHCA patients treated with ECPR in a multicenter setting. METHODS: This is a secondary analysis of the SAVE-J II study, which was a multicenter, retrospective cohort of OHCA patients treated with ECPR. Age, sex, comorbidities, presence of witnessed CA, presence of bystander CPR, initial rhythm, cause of CA, low-flow time, initiation of targeted temperature management, details of sputum culture, pneumonia, and prophylactic antibiotic use were recorded...
December 2023: Resuscitation plus
https://read.qxmd.com/read/37730169/identification-of-contributing-factors-microorganisms-and-antimicrobial-resistance-involved-in-the-complication-of-diabetic-foot-ulcer-treatment
#17
JOURNAL ARTICLE
Muhammad Shakil Khan, Maleeha Azam, Muhammad Nadeem Khan, Foha Syed, Syeda Hafiza Benish Ali, Tauqeer Ahmed Malik, Sulaiman Mohammed Abdullah Alnasser, Ashfaq Ahmad, Shaik Karimulla, Reheel Qamar
Diabetic foot ulcer (DFU) is a neurological and peripherical complication of diabetes with unknown etiology that is often associated with polymicrobial infections. The present study was conducted to investigate the contributing factors in 285 DFU patients, which included 200 patients with diabetic foot infections (DFI). Identification and characterization of infecting bacterial isolates were done followed by assessment of their pattern of susceptibility to commonly used antibiotics. Among the studied subjects, type 2 diabetes mellitus (T2DM), ulcer type, depth, grade, loss of sensation, infection type, affected foot, recurrence, smoking status, Body Mass Index (BMI), and obesity levels revealed significant disease risk association...
September 18, 2023: Microbial Pathogenesis
https://read.qxmd.com/read/37685509/contemporary-clinical-profile-of-left-sided-native-valve-infective-endocarditis-influence-of-the-causative-microorganism
#18
JOURNAL ARTICLE
Gonzalo Cabezón, María de Miguel, Javier López, Isidre Vilacosta, Paloma Pulido, Carmen Olmos, Adrián Jerónimo, Javier B Pérez, Adrián Lozano, Itzíar Gómez, J Alberto San Román
Studies focused on the clinical profile of native valve endocarditis are scarce and outdated. In addition, none of them analyzed differences depending on the causative microorganism. Our objectives are to describe the clinical profile at admission of patients with left-sided native valve infective endocarditis in a contemporary wide series of patients and to compare them among the most frequent etiologies. To do so, we conducted a prospective, observational cohort study including 569 patients with native left-sided endocarditis enrolled from 2006 to 2019...
August 22, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37664334/a-rare-multilevel-spinal-epidural-abscess-with-streptococcus-agalactiae-in-an-adult-with-uncontrolled-diabetes-a-case-report
#19
Karanvir S Kals, Aakriti Ramayani, Radhika Hariharan, Thomas T Lee
Spinal epidural abscess (SEA) is a rare, life-threatening infection that typically presents with fever, back pain, and neurologic deficits. Although most commonly caused by Staphylococcus aureus , this case reviews a rare occurrence of a multilevel SEA caused by Streptococcus agalactiae in a 62-year-old female with uncontrolled type II diabetes mellitus. The patient initially presented with lower back pain and was subsequently diagnosed with a SEA complicated by hyperglycemia. A prompt diagnosis with magnetic resonance imaging (MRI) revealed extensive abscess formation, leading to emergent neurosurgical intervention...
August 2023: Curēus
https://read.qxmd.com/read/37653834/group-a-streptococcus-dysgalactiae-subspecies-equisimilis-vertebral-osteomyelitis-accompanied-by-progressive-atlantoaxial-subluxation-a-case-report-and-literature-review
#20
JOURNAL ARTICLE
Hirokazu Toyoshima, Motoaki Tanigawa, Chiaki Ishiguro, Hiroyuki Tanaka, Yuki Nakanishi, Shigetoshi Sakabe
RATIONALE: Clinically, vertebral osteomyelitis commonly occurs in immunocompromised individuals, such as people with diabetes, immunosuppression, chronic liver disease, and malignancy. Microbiologically, vertebral osteomyelitis is commonly caused by Staphylococcus aureus; however, Streptococcus dysgalactiae subspecies equisimilis (SDSE) may also potentially cause vertebral osteomyelitis, albeit rarely. Since no case reports have documented the occurrence of SDSE cervical osteomyelitis accompanied by progressive atlantoaxial subluxation, its clinical characteristics remain uncertain...
August 25, 2023: Medicine (Baltimore)
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