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https://www.readbyqxmd.com/read/28821631/6-methoxyethylamino-numonafide-inhibits-hepatocellular-carcinoma-xenograft-growth-as-a-single-agent-and-in-combination-with-sorafenib
#1
Yanning Liu, Guohua Lou, John T Norton, Chen Wang, Irawati Kandela, Shuai Tang, Nathaniel I Shank, Pankaj Gupta, Min Huang, Michael J Avram, Richard Green, Andrew Mazar, Daniel Appella, Zhi Chen, Sui Huang
Hepatocellular carcinoma (HCC) is the third leading form of cancer worldwide, and its incidence is increasing rapidly in the United States, tripling over the past 3 decades. The current chemotherapeutic strategies against localized and metastatic HCC are ineffective. Here we report that 6-methoxyethylamino-numonafide (MEAN) is a potent growth inhibitor of murine xenografts of 2 human HCC cell lines. At the same dose and with the same treatment strategies, MEAN was more efficacious in inhibiting tumor growth in mice than sorafenib, the only approved drug for HCC...
August 17, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28817093/quality-of-vegetables-based-on-total-phenolic-concentration-is-lower-in-more-rural-consumer-food-environments-in-a-rural-american-state
#2
Selena Ahmed, Carmen Byker Shanks
While daily consumption of fruits and vegetables (FVs) is widely recognized to be associated with supporting nutrition and health, disparities exist in consumer food environments regarding access to high-quality produce based on location. The purpose of this study was to evaluate FV quality using total phenolic (TP) scores (a phytochemical measure for health-promoting attributes, flavor, appearance, and shelf-life) in consumer food environments along a rural to urban continuum in the rural state of Montana, United States...
August 17, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28814467/input-from-the-medial-geniculate-nucleus-modulates-amygdala-encoding-of-fear-memory-discrimination
#3
Nicole C Ferrara, Patrick K Cullen, Shane P Pullins, Elena K Rotondo, Fred J Helmstetter
Generalization of fear can involve abnormal responding to cues that signal safety and is common in people diagnosed with post-traumatic stress disorder. Differential auditory fear conditioning can be used as a tool to measure changes in fear discrimination and generalization. Most prior work in this area has focused on elevated amygdala activity as a critical component underlying generalization. The amygdala receives input from auditory cortex as well as the medial geniculate nucleus (MgN) of the thalamus, and these synapses undergo plastic changes in response to fear conditioning and are major contributors to the formation of memory related to both safe and threatening cues...
September 2017: Learning & Memory
https://www.readbyqxmd.com/read/28814012/quantitative-measures-with-wrex-usage
#4
Tracy M Shank, Jinyong Wee, Jennifer Ty, Tariq Rahman
This paper presents the results of two surveys conducted with users of a functional upper extremity orthosis called the Wilmington Robotic EXoskeleton (WREX). The WREX is a passive anti-gravity arm orthosis that allows people with neuromuscular disabilities to move their arms in three dimensions. An online user survey with 55 patients was conducted to determine the benefits of the WREX. The survey asked 10 questions related to upper extremity function with and without the WREX as well as subjective impressions of the device...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813995/a-novel-human-effort-estimation-method-for-knee-assistive-exoskeletons
#5
Lorenzo Saccares, Anais Brygo, Ioannis Sarakoglou, Nikos G Tsagarakis
In this work we present a novel method to estimate online the torques at the knee joints with the goal to generate reference signals for knee assistive devices. One of the main advantages of the proposed approach is its reduced sensing requirements, which leads to an ergonomic setup with minimal instrumentation, especially above the knee and of the upper body. Indeed, only the measurement of the forces and torques exchanged between the ground and the user's feet, the posture of the shanks, and the model of the user's shank itself are needed for the estimation of the knee torque...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813858/active-impedance-control-of-a-knee-joint-orthosis-during-swing-phase
#6
Fatima El Zahraa Wehbi, Weiguang Huo, Yacine Amirat, Maher El Rafei, Mohamad Khalil, Samer Mohammed
In this paper, an active impedance control strategy for a knee-joint orthosis is proposed to assist individuals suffering from lower-limb muscular weaknesses during the swing phase of walking activities. The goal of the proposed strategy is to decrease the human effort required for ensuring a successful knee joint movement during walking without sacrificing the wearer's control priority. In this study, a gait-phase based desired knee-joint admittance model is designed by analyzing the kinematic and kinetic characteristics of the wearer's shank-foot segment during walking...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813820/design-of-an-exoskeleton-ankle-robot-for-robot-assisted-gait-training-of-stroke-patients
#7
Ling-Fung Yeung, Corinna Ockenfeld, Man-Kit Pang, Hon-Wah Wai, Oi-Yan Soo, Sheung-Wai Li, Kai-Yu Tong
Lower Limb Exoskeleton robot that can facilitate stair walking is a big challenge, most systems could only provide level ground walking. In this study, a lightweight (0.5kg at ankle, 0.5kg at waist for control box) and autonomous exoskeleton Ankle Robot was proposed to provide power assistance for gait training of chronic stroke patients and it can facilitate three walking conditions in real-time: (1) level walking, (2) stair ascending, and (3) stair descending. Chronic stroke patients (n=3) with drop foot gait deficit and moderate motor impairment were recruited to evaluate the system under different walking conditions (Functional Ambulatory Category: FAC=4...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813786/prediction-of-gait-events-in-walking-activities-with-a-bayesian-perception-system
#8
Uriel Martinez-Hernandez, Mohammed I Awad, Imran Mahmood, Abbas A Dehghani-Sanij
In this paper, a robust probabilistic formulation for prediction of gait events from human walking activities using wearable sensors is presented. This approach combines the output from a Bayesian perception system with observations from actions and decisions made over time. The perception system makes decisions about the current gait events, while observations from decisions and actions allow to predict the most probable gait event during walking activities. Furthermore, our proposed method is capable to evaluate the accuracy of its predictions, which permits to obtain a better performance and trade-off between accuracy and speed...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28807638/food-waste-in-the-national-school-lunch-program-1978-2015-a-systematic-review
#9
Carmen Byker Shanks, Jinan Banna, Elena L Serrano
BACKGROUND: Food waste studies have been used for more than 40 years to assess nutrient intake, dietary quality, menu performance, food acceptability, cost, and effectiveness of nutrition education in the National School Lunch Program (NSLP). OBJECTIVE: Describe methods used to measure food waste and respective results in the NSLP across time. METHODS: A systematic review using PubMed, Science Direct, Informaworld, and Institute of Scientific Information Web of Knowledge was conducted using the following search terms: waste, school lunch, plate waste, food waste, kitchen, half method, quarter method, weight, and photography...
August 11, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28803131/do-continuum-beliefs-reduce-schizophrenia-stigma-effects-of-a-laboratory-intervention-on-behavioral-and-self-reported-stigma
#10
Ryan Thibodeau, Lindsay N Shanks, Brian P Smith
BACKGROUND AND OBJECTIVES: Correlational research shows that belief in a continuum of psychiatric problems predicts decreased public stigma. However, the correlational findings fail to inform the stigma reduction prospects of manipulating continuum beliefs. All extant experimental work has been executed online. This study examined effects of a laboratory-based continuum intervention on behavioral and self-report measures of psychiatric stigma. METHODS: Sixty-nine undergraduates believed that they would meet a man with schizophrenia...
August 5, 2017: Journal of Behavior Therapy and Experimental Psychiatry
https://www.readbyqxmd.com/read/28801797/planar-covariance-of-upper-and-lower-limb-elevation-angles-during-hand-foot-crawling-in-healthy-young-adults
#11
M J MacLellan, G Catavitello, Y P Ivanenko, F Lacquaniti
Habitual quadrupeds have been shown to display a planar covariance of segment elevation angle waveforms in the fore and hind limbs during many forms of locomotion. The purpose of the current study was to determine if humans generate similar patterns in the upper and lower limbs during hand-foot crawling. Nine healthy young adults performed hand-foot crawling on a treadmill at speeds of 1, 2, and 3 km/h. A principal component analysis (PCA) was applied to the segment elevation angle waveforms for the upper (upper arm, lower arm, and hand) and lower (thigh, shank, and foot) limbs separately...
August 11, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28800828/culture-dependent-and-culture-independent-assessment-of-spoilage-community-growth-on-vp-lamb-meat-from-packaging-to-past-end-of-shelf-life
#12
Mandeep Kaur, Hongshan Shang, Mark Tamplin, Tom Ross, John P Bowman
Packaging and storage temperature are important factors that influence the shelf-life of vacuum packed (VP) meat. In this study the shelf-life of VP bone-in lamb hind shanks stored at 8 °C and -1.2 °C was determined in parallel to analyses of starting and eventual spoilage bacterial communities via Illumina MiSeq based 16S rRNA amplicon sequencing. The mean total viable counts (TVC) and lactic acid bacterial viable counts (LAB) were observed to increase to log 7.5 CFU/cm(2) and 7 CFU/cm(2) after 6 and 42 days at 8 °C and -1...
December 2017: Food Microbiology
https://www.readbyqxmd.com/read/28798239/interaction-of-munc18c-and-syntaxin4-facilitates-invadopodium-formation-and-extracellular-matrix-invasion-of-tumour-cells
#13
Megan I Brasher, David M Martynowicz, Olivia R Grafinger, Andrea Hucik, Emma Shanks-Skinner, James Uniacke, Marc G Coppolino
Tumor cell invasion involves targeted localization of proteins required for interactions of the extracellular matrix (ECM) and for proteolysis. The localization of many proteins during these cell-ECM interactions relies on membrane trafficking mediated in part by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The SNARE protein syntaxin4 (Stx4) is involved in the formation of invasive structures called invadopodia; however, it is unclear how Stx4 function is regulated during tumor cell invasion...
August 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28795237/the-adaptive-evolution-database-taed-a-new-release-of-a-database-of-phylogenetically-indexed-gene-families-from-chordates
#14
Russell A Hermansen, Benjamin P Oswald, Stormy Knight, Stephen D Shank, David Northover, Katharine L Korunes, Stephen N Michel, David A Liberles
With the large collections of gene and genome sequences, there is a need to generate curated comparative genomic databases that enable interpretation of results in an evolutionary context. Such resources can facilitate an understanding of the co-evolution of genes in the context of a genome mapped onto a phylogeny, of a protein structure, and of interactions within a pathway. A phylogenetically indexed gene family database, the adaptive evolution database (TAED), is presented that organizes gene families and their evolutionary histories in a species tree context...
August 9, 2017: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/28781982/influence-of-cathode-geometry-on-electron-dynamics-in-an-ultrafast-electron-microscope
#15
Shaozheng Ji, Luca Piazza, Gaolong Cao, Sang Tae Park, Bryan W Reed, Daniel J Masiel, Jonas Weissenrieder
Efforts to understand matter at ever-increasing spatial and temporal resolutions have led to the development of instruments such as the ultrafast transmission electron microscope (UEM) that can capture transient processes with combined nanometer and picosecond resolutions. However, analysis by UEM is often associated with extended acquisition times, mainly due to the limitations of the electron gun. Improvements are hampered by tradeoffs in realizing combinations of the conflicting objectives for source size, emittance, and energy and temporal dispersion...
September 2017: Structural Dynamics (Melville, N.Y.)
https://www.readbyqxmd.com/read/28781123/the-high-affinity-interaction-between-orc-and-dna-that-is-required-for-replication-licensing-is-inhibited-by-2-arylquinolin-4-amines
#16
Nicola J Gardner, Peter J Gillespie, Jamie T Carrington, Emma J Shanks, Stuart P McElroy, Emma J Haagensen, Julie A Frearson, Andrew Woodland, J Julian Blow
In late mitosis and G1, origins of DNA replication must be "licensed" for use in the upcoming S phase by being encircled by double hexamers of the minichromosome maintenance proteins MCM2-7. A "licensing checkpoint" delays cells in G1 until sufficient origins have been licensed, but this checkpoint is lost in cancer cells. Inhibition of licensing can therefore kill cancer cells while only delaying normal cells in G1. In a high-throughput cell-based screen for licensing inhibitors we identified a family of 2-arylquinolin-4-amines, the most potent of which we call RL5a...
August 17, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28770435/implication-of-endoplasmic-reticulum-stress-in-autism-spectrum-disorder
#17
Koichi Kawada, Seisuke Mimori
Autism spectrum disorder (ASD) is categorized as a neurodevelopmental disorder according to the Diagnostic and Statistical Manual of Disorders, Fifth Edition and is defined as a congenital impairment of the central nervous system. ASD may be caused by a chromosomal abnormality or gene mutation. However, these etiologies are insufficient to account for the pathogenesis of ASD. Therefore, we propose that the etiology and pathogenesis of ASD are related to the stress of the endoplasmic reticulum (ER). ER stress, induced by valproic acid, increased in ASD mouse model, characterized by an unfolded protein response that is activated by this stress...
August 2, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28767683/quantifying-kinematic-differences-between-land-and-water-during-squats-split-squats-and-single-leg-squats-in-a-healthy-population
#18
Anna C Severin, Brendan J Burkett, Mark R McKean, Aaron N Wiegand, Mark G L Sayers
Aquatic exercises can be used in clinical and sporting disciplines for both rehabilitation and sports training. However, there is limited knowledge on the influence of water immersion on the kinematics of exercises commonly used in rehabilitation and fitness programs. The aim of this study was to use inertial sensors to quantify differences in kinematics and movement variability of bodyweight squats, split squats, and single-leg squats performed on dry land and whilst immersed to the level of the greater trochanter...
2017: PloS One
https://www.readbyqxmd.com/read/28758789/misunderstanding-the-behavior-priming-controversy-comment-on-payne-brown-iannuzzi-and-loersch-2016
#19
David R Shanks
There has been considerable controversy around the limits and reproducibility of so-called "behavior" priming effects. Payne, Brown-Iannuzzi, and Loersch (2016) reported a series of 6 experiments on the effects of primes on participants' bets in a simulated blackjack game, and claimed that their findings not only establish the reality of behavior priming beyond dispute, but also demonstrate that this form of priming has the crucial hallmark of occurring outside participants' awareness and control. I describe a statistical model that does not distinguish automatic and controlled processes, but which nonetheless reproduces Payne et al...
August 2017: Journal of Experimental Psychology. General
https://www.readbyqxmd.com/read/28756984/a-55-year-old-female-with-leukoencephalopathy-with-cerebral-calcifications-and-cysts-case-report-and-radiopathologic-description
#20
Jorge Novo, Diana Lin, Megan Shanks, Mehmet Kocak, Leonidas Arvanitis
Adult-onset leukoencephalopathies with increased cerebral volume can present a potentially challenging diagnosis for the pathologist. We present the case of a patient with a rare adult-onset disease called Leukoencephalopathy with cerebral Calcifications and Cysts (LCC). A 55-year-old woman with a history of morning headaches, mild memory loss, diabetes, and hypertension presented to the emergency department with acute onset altered mental status. CT scan revealed multiple small hypodense lesions in the white matter with calcifications in the bilateral cerebral hemispheres, basal ganglia, pons, and cerebellar hemispheres...
July 6, 2017: Pathology, Research and Practice
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