keyword
MENU ▼
Read by QxMD icon Read
search

Shank

keyword
https://www.readbyqxmd.com/read/28444128/low-dose-ionizing-radiation-induces-therapeutic-neovascularization-in-a-pre-clinical-model-of-hindlimb-ischemia
#1
Augusto Ministro, Paula de Oliveira, Raquel J Nunes, André Dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D Becker, J Goyri-O'Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
We have previously shown that low-dose ionizing radiation (LDIR) induces angiogenesis but there is no evidence that they induce neovascularization in the setting of peripheral arterial disease. Here, we investigated the use of LDIR as an innovative and non-invasive strategy to stimulate therapeutic neovascularization using a model of experimentally induced hindlimb ischemia (HLI). Methods and results: After surgical induction of unilateral HLI, both hindlimbs of female C57BL/6 mice were sham-irradiated or irradiated with four daily fractions of 0...
April 19, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28439355/using-the-entrustable-professional-activities-framework-in-the-assessment-of-procedural-skills
#2
Debra Pugh, Rodrigo B Cavalcanti, Samantha Halman, Irene W Y Ma, Maria Mylopoulos, David Shanks, Lynfa Stroud
BACKGROUND: The entrustable professional activity (EPA) framework has been identified as a useful approach to assessment in competency-based education. To apply an EPA framework for assessment, essential skills necessary for entrustment to occur must first be identified. OBJECTIVE: Using an EPA framework, our study sought to (1) define the essential skills required for entrustment for 7 bedside procedures expected of graduates of Canadian internal medicine (IM) residency programs, and (2) develop rubrics for the assessment of these procedural skills...
April 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/28437333/correction-capability-in-the-3-anatomic-planes-of-different-pedicle-screw-designs-in-scoliosis-instrumentation
#3
Xiaoyu Wang, Carl-Eric Aubin, John Coleman, Jeremy Rawlinson
STUDY DESIGN: Computer simulations to compare the correction capabilities of different pedicle screws in adolescent idiopathic scoliosis (AIS) instrumentations. OBJECTIVE: To compare the correction and resulting bone-screw forces associated with different pedicle screws in scoliosis instrumentations. SUMMARY OF BACKGROUND DATA: Pedicle screw fixation is widely used in surgical instrumentation for spinal deformity treatment. Screw design, correction philosophies, and surgical techniques are constantly evolving to achieve better control of the vertebrae and correction of the spinal deformity...
May 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28435927/traumatic-dislocation-of-the-s1-polyaxial-pedicle-screw-head-a-case-report
#4
Pieter N B Du Plessis, Bernard P H Lau, Hwee Weng Dennis Hey
Polyaxial screw head dislocation in the absence of a manufacture defect is extremely rare and represents a biomechanical overload of the screw, leading to early failure. A 58-year-old gentleman underwent instrumented fusion using polyaxial pedicle screws-titanium rod construct with interbody cage for spondylolytic spondylolisthesis at the L5/S1 level. He attempted to bend forward ten days after the surgery which resulted in a dislocation of the right S1 polyaxial screw head from the screw shank with recurrence of symptoms...
March 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28433327/replacing-antibodies-with-modified-dna-aptamers-in-vaccine-potency-assays
#5
Jeremiah J Trausch, Mary Shank-Retzlaff, Thorsten Verch
Vaccine in vitro potency assays are vital regulatory tests that are used to confirm the presence and concentration of an antigen of interest in a form that directly or indirectly relates to protective activity in patients. Current assays come in many forms, but they almost exclusively use antibody reagents for selective detection of the target antigen. Antibodies provide specific recognition of vaccine antigens but also exhibit drawbacks such as stability limitations, cost, and lot-to-lot variation, which can make it challenging to maintain the reagent throughout the lifetime of the vaccine...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28433162/tocopheryl-acetate-release-from-microcapsules-of-waxy-maize-starch
#6
Naksit Panyoyai, Robert A Shanks, Stefan Kasapis
Diffusion coefficients are utilised to provide a realistic approach in the quantification of mass transport phenomena, which are important for the delivery of bioactivity from high-solid biopolymer systems. Following this mechanistic consideration, we employ spray drying to produce microcapsules of waxy maize starch that suspend homogeneously tocopheryl acetate. An array of physicochemical techniques including dynamic oscillation in-shear or compression mode, microDSC, WAXD, FTIR, scanning electron or optical microscopy, and UV-vis assays were utilised to relate structural properties of the macromolecular network to diffusivity of the bioactive compound...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28427323/detection-of-qtl-for-traits-related-to-adaptation-to-sub-optimal-climatic-conditions-in-chickens
#7
Ching-Yi Lien, Michèle Tixier-Boichard, Shih-Wen Wu, Woei-Fuh Wang, Chen Siang Ng, Chih-Feng Chen
BACKGROUND: Growth traits can be used as indicators of adaptation to sub-optimal conditions. The current study aimed at identifying quantitative trait loci (QTL) that control performance under variable temperature conditions in chickens. METHODS: An F2 population was produced by crossing the Taiwan Country chicken L2 line (selected for body weight, comb area, and egg production) with an experimental line of Rhode Island Red layer R- (selected for low residual feed consumption)...
April 20, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28426512/technology-in-s-c-assessing-bodyweight-squat-technique-with-wearable-sensors
#8
Martin A O'Reilly, Darragh F Whelan, Tomas E Ward, Eamonn Delahunt, Brian M Caulfield
Strength and conditioning (S&C) coaches offer expert guidance to help those they work with achieve their personal fitness goals. However it is not always practical to operate under the direct supervision of an S&C coach and consequently individuals are often left training without expert oversight. Recent developments in inertial measurement units (IMUs) and mobile computing platforms have allowed for the possibility of unobtrusive motion tracking systems and the provision of real-time individualised feedback regarding exercise performance...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28422663/a-neural-probe-with-up-to-966-electrodes-and-up-to-384-configurable-channels-in-0-13-%C3%AE-m-soi-cmos
#9
Carolina Mora Lopez, Jan Putzeys, Bogdan Cristian Raducanu, Marco Ballini, Shiwei Wang, Alexandru Andrei, Veronique Rochus, Roeland Vandebriel, Simone Severi, Chris Van Hoof, Silke Musa, Nick Van Helleputte, Refet Firat Yazicioglu, Srinjoy Mitra
In vivo recording of neural action-potential and local-field-potential signals requires the use of high-resolution penetrating probes. Several international initiatives to better understand the brain are driving technology efforts towards maximizing the number of recording sites while minimizing the neural probe dimensions. We designed and fabricated (0.13- μm SOI Al CMOS) a 384-channel configurable neural probe for large-scale in vivo recording of neural signals. Up to 966 selectable active electrodes were integrated along an implantable shank (70 μm wide, 10 mm long, 20  μm thick), achieving a crosstalk of [Formula: see text] dB...
April 14, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28418594/massive-crab-recruitment-events-to-the-shallow-subtidal-zone
#10
Aaron W E Galloway, Alan L Shanks, Scott Groth, Scott R Marion, Andrew R Thurber
No abstract text is available yet for this article.
April 18, 2017: Ecology
https://www.readbyqxmd.com/read/28410738/soft-tissue-artefacts-of-skin-markers-on-the-lower-limb-during-cycling-effects-of-joint-angles-and-pedal-resistance
#11
Jia-Da Li, Tung-Wu Lu, Cheng-Chung Lin, Mei-Ying Kuo, Horng-Chaung Hsu, Wu-Chung Shen
Soft tissue artefacts (STA) are a major error source in skin marker-based measurement of human movement, and are difficult to eliminate non-invasively. The current study quantified in vivo the STA of skin markers on the thigh and shank during cycling, and studied the effects of knee angles and pedal resistance by using integrated 3D fluoroscopy and stereophotogrammetry. Fifteen young healthy adults performed stationary cycling with and without pedal resistance, while the marker data were measured using a motion capture system, and the motions of the femur and tibia/fibula were recorded using a bi-plane fluoroscopy-to-CT registration method...
April 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28410467/examination-of-the-interpersonal-model-of-loss-of-control-eating-in-the-laboratory
#12
Lisa M Shank, Ross D Crosby, Anne Claire Grammer, Lauren B Shomaker, Anna Vannucci, Natasha L Burke, Monika Stojek, Sheila M Brady, Merel Kozlosky, James C Reynolds, Jack A Yanovski, Marian Tanofsky-Kraff
BACKGROUND: The interpersonal model of loss of control (LOC) eating proposes that interpersonal problems lead to negative affect, which in turn contributes to the onset and/or persistence of LOC eating. Despite preliminary support, there are no data examining the construct validity of the interpersonal model of LOC eating using temporally sensitive reports of social stress, distinct negative affective states, and laboratory energy intake. METHOD: 117 healthy adolescent girls (BMI: 75th-97th %ile) were recruited for a prevention trial targeting excess weight gain in adolescent girls who reported LOC eating...
April 3, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28396152/evolutionary-origins-of-pectin-methylesterase-genes-associated-with-novel-aspects-of-angiosperm-pollen-tube-walls
#13
Simon Wallace, Joseph H Williams
The early evolution of angiosperms was marked by a number of innovations of the reproductive cycle including an accelerated fertilization process involving faster transport of sperm to the egg via a pollen tube. Fast pollen tube growth rates in angiosperms are accompanied by a hard shank-soft tip pollen tube morphology. A critical actor in that morphology is the wall-embedded enzyme pectin methylesterase (PME), which in type II PMEs is accompanied by a co-transcribed inhibitor, PMEI. PMEs convert the esterified pectic tip wall to a stiffer state in the subapical flank by pectin de-esterification...
April 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28395128/probing-mercaptobenzamides-as-hiv-inactivators-via-nucleocapsid-protein-7
#14
Mrinmoy Saha, Michael T Scerba, Nathaniel I Shank, Tracy L Hartman, Caitlin A Buchholz, Robert W Buckheit, Stewart R Durell, Daniel H Appella
Human immunodeficiency virus type 1 (HIV-1) nucleocapsid protein 7 (NCp7), a zinc finger protein, plays critical roles in viral replication and maturation and represents an attractive target for drug development. However, development of drug-like molecules that inhibit NCp7 has been a significant challenge. In this report, a series of novel 2-mercaptobenzamide prodrugs have been investigated for anti-HIV activity in the context of NCp7 inactivation. The molecules are synthesized from the corresponding thiosalicylic acids, and they are all crystalline solids and stable at room temperature...
April 10, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28386253/current-and-potential-treatments-for-reducing-campylobacter-colonization-in-animal-hosts-and-disease-in-humans
#15
REVIEW
Tylor J Johnson, Janette M Shank, Jeremiah G Johnson
Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming under-cooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28386047/reply-to-shanks-and-brundage-many-plausible-mechanisms-of-pandemic-mortality-disparities
#16
Kyra H Grantz, Madhura S Rane, Henrik Salje, Gregory E Glass, Stephen E Schachterle, Derek A T Cummings
No abstract text is available yet for this article.
April 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28378537/associative-covalent-relay-an-oxadiazolone-strategy-for-rhodium-iii-catalyzed-synthesis-of-primary-pyridinylamines
#17
Xiaolong Yu, Kehao Chen, Qi Wang, Shan Guo, Shanke Zha, Jin Zhu
A relay formalism is proposed herein for categorizing the interplay among reactants, target product, and catalytic center in transition-metal catalysis, an important factor that can dictate overall catalysis viability and efficiency. In this formalism, transition-metal catalysis can proceed by dissociative relay, associative covalent relay, and associative dative relay modes. An intriguing associative covalent relay process operates in rhodium(III)-catalyzed oxadiazolone-directed alkenyl C-H coupling with alkynes and allows efficient access to primary pyridinylamines...
May 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28373195/structural-modification-of-lipopolysaccharide-conferred-by-mcr-1-in-gram-negative-eskape-pathogens
#18
Yi-Yun Liu, Courtney E Chandler, Lisa M Leung, Christi L McElheny, Roberta T Mettus, Robert M Q Shanks, Jian-Hua Liu, David R Goodlett, Robert K Ernst, Yohei Doi
mcr-1 was initially reported as the first plasmid-mediated colistin resistance gene in clinical isolates of Escherichia coli and Klebsiella pneumoniae in China and has subsequently been identified worldwide in various species of the family Enterobacteriaceae. mcr-1 encodes a phosphoethanolamine transferase and its expression has been shown to generate phosphoethanolamine-modified bis-phosphorylated hexa-acylated lipid A in E. coli Here, we investigated the effect of mcr-1 on colistin susceptibility and lipopolysaccharide structures in laboratory and clinical strains of the Gram-negative ESKAPE pathogens, which are often treated by colistin clinically...
April 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28372154/effect-of-salt-on-the-glass-transition-of-condensed-tapioca-starch-systems
#19
Lillian Chuang, Naksit Panyoyai, Robert A Shanks, Stefan Kasapis
This work examines the effect of including hydrated NaCl and CaCl2 (up to 6% w/w) on the physicochemical properties of condensed tapioca starch. Samples were prepared by hot pressing at 120°C to produce condensed systems that covered a range of moisture contents from 7.34% w/w (23% relative humidity) to 19.52% w/w (75% relative humidity). Tensile storage modulus and heat flow measurements were taken using DMA and MDSC, which were accompanied by FTIR, WAXD and ESEM. Increasing the salt level enhances the mechanical strength of starch in the glassy state and shifts the glass transition temperature to a higher value...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28370947/prevention-of-insulin-resistance-in-adolescents-at-risk-for-type-2-diabetes-with-depressive-symptoms-1-year-follow-up-of-a-randomized-trial
#20
Lauren B Shomaker, Nichole R Kelly, Rachel M Radin, Omni L Cassidy, Lisa M Shank, Sheila M Brady, Andrew P Demidowich, Cara H Olsen, Kong Y Chen, Eric Stice, Marian Tanofsky-Kraff, Jack A Yanovski
BACKGROUND: Depression is associated with poor insulin sensitivity. We evaluated the long-term effects of a cognitive behavioral therapy (CBT) program for prevention of depression on insulin sensitivity in adolescents at risk for type 2 diabetes (T2D) with depressive symptoms. METHODS: One-hundred nineteen adolescent females with overweight/obesity, T2D family history, and mild-to-moderate depressive symptoms were randomized to a 6-week CBT group (n = 61) or 6-week health education (HE) control group (n = 58)...
March 31, 2017: Depression and Anxiety
keyword
keyword
11717
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"