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https://www.readbyqxmd.com/read/29048396/time-multiplexed-active-neural-probe-with-1356-parallel-recording-sites
#1
Bogdan C Raducanu, Refet F Yazicioglu, Carolina M Lopez, Marco Ballini, Jan Putzeys, Shiwei Wang, Alexandru Andrei, Veronique Rochus, Marleen Welkenhuysen, Nick van Helleputte, Silke Musa, Robert Puers, Fabian Kloosterman, Chris van Hoof, Richárd Fiáth, István Ulbert, Srinjoy Mitra
We present a high electrode density and high channel count CMOS (complementary metal-oxide-semiconductor) active neural probe containing 1344 neuron sized recording pixels (20 µm × 20 µm) and 12 reference pixels (20 µm × 80 µm), densely packed on a 50 µm thick, 100 µm wide, and 8 mm long shank. The active electrodes or pixels consist of dedicated in-situ circuits for signal source amplification, which are directly located under each electrode. The probe supports the simultaneous recording of all 1356 electrodes with sufficient signal to noise ratio for typical neuroscience applications...
October 19, 2017: Sensors
https://www.readbyqxmd.com/read/29040328/integrin-beta-1-inhibition-alleviates-the-chronic-hyperproliferative-dermatitis-phenotype-of-sharpin-deficient-mice
#2
Emilia Peuhu, Siiri I Salomaa, Nicola De Franceschi, Christopher S Potter, John P Sundberg, Jeroen Pouwels
SHARPIN (Shank-Associated RH Domain-Interacting Protein) is a component of the linear ubiquitin chain assembly complex (LUBAC), which enhances TNF-induced NF-κB activity. SHARPIN-deficient (Sharpincpdm/cpdm) mice display multi-organ inflammation and chronic proliferative dermatitis (cpdm) due to TNF-induced keratinocyte apoptosis. In cells, SHARPIN also inhibits integrins independently of LUBAC, but it has remained enigmatic whether elevated integrin activity levels in the dermis of Sharpincpdm/cpdm mice is due to increased integrin activity or is secondary to inflammation...
2017: PloS One
https://www.readbyqxmd.com/read/29040051/two-novel-capn5-variants-associated-with-mild-and-severe-autosomal-dominant-neovascular-inflammatory-vitreoretinopathy-phenotypes
#3
Nadia M Randazzo, Morag E Shanks, Penny Clouston, Robert E MacLaren
PURPOSE: We report two new CAPN5 mutations associated with a phenotype of Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy. METHODS: We performed next generation sequencing in two patients with ADNIV phenotype; the variants identified were explored further. RESULTS: Patient 1 was heterozygous for CAPN5 c.799G>A, p.(Gly267Ser). Patient 2 was heterozygous for CAPN5 c.1126G>A, p.(Gly376Ser). Both amino acids are highly conserved across species...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29036502/three-cases-of-fatal-acrylfentanyl-toxicity-in-the-united-states-and-a-review-of-literature
#4
Daniel C Butler, Kevin Shanks, George S Behonick, Dustin Smith, Susan E Presnell, Lee Marie Tormos
Fentanyl analogs pose a unique challenge for forensic pathologists and toxicologists. The extreme potency of these analogs results in minute blood, urine and vitreous concentrations that are technically difficult to identify. This in addition to their absence from standard drug screening may potentiate a setting of apparent drug overdose without an immediately identifiable source. The following case series illustrates three such encounters with acrylfentanyl, an analog whose presence has not yet been reported in the scientific literature in the United States...
September 28, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29029325/guidelines-for-the-use-of-electrophysiological-monitoring-for-surgery-of-the-human-spinal-column-and-spinal-cord
#5
Mark N Hadley, Christopher D Shank, Curtis J Rozzelle, Beverly C Walters
No abstract text is available yet for this article.
September 27, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29028626/accuracy-of-three-methods-in-gait-event-detection-during-overground-running
#6
Shiwei Mo, Daniel H K Chow
Inertial measurement units (IMUs) have been extensively used to detect gait events. Various methods have been proposed for detecting initial contact (IC) and toe-off (TO) using IMUs affixed at various anatomical locations. However, the accuracy of such methods has yet to be compared. This study evaluated the accuracy of three common methods used for detecting gait events during jogging and running: (1) S-method, in which IC is identified as the instant of peak foot-resultant acceleration and TO is identified when the acceleration exceeds a threshold of 2g in the region of interest; (2) M-method, in which IC and TO are defined as the minimum before the positive peak shank vertical acceleration and the minimum in the region of interest, respectively; and (3) L-method, in which IC is indicated by the instant of peak pelvis anteroposterior acceleration and TO is identified by the maximum in the region of interest...
October 6, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29025348/safety-assessment-of-diethanolamine-and-its-salts-as-used-in-cosmetics
#7
Monice M Fiume, Bart Heldreth, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of diethanolamine and its salts as used in cosmetics. Diethanolamine functions as a pH adjuster; the 16 salts included in this rereview reportedly function as surfactants, emulsifying agents, viscosity increasing agents, hair or skin conditioning agents, foam boosters, or antistatic agents. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports. Since data were not available for each individual ingredient, and since the salts dissociate freely in water, the Panel extrapolated from previous reports to support safety...
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29025328/safety-assessment-of-cross-linked-alkyl-acrylates-as-used-in-cosmetics
#8
Monice M Fiume, Bart Heldreth, Ivan Boyer, Wilma F Bergfeld, Donald V Belsito, Ronald A Hill, Curtis D Klaassen, Daniel C Liebler, James G Marks, Ronald C Shank, Thomas J Slaga, Paul W Snyder, F Alan Andersen
The Cosmetic Ingredient Review (CIR) Expert Panel assessed the safety of cross-linked alkyl acrylates as used in cosmetics. The 23 cross-linked alkyl acrylates included in this safety assessment are reported to function as absorbents, film formers, emulsion stabilizers, viscosity increasing agents, suspending agents, binders, and/or skin-conditioning agents. The Panel reviewed available animal and clinical data, as well as information from previous CIR reports on monomer components. Because data were not available for the individual ingredients, and because residual monomer may be present, the Panel extrapolated from previous reports to support safety...
September 2017: International Journal of Toxicology
https://www.readbyqxmd.com/read/29021827/coordination-among-the-rearfoot-midfoot-and-forefoot-during-walking
#9
Tomoya Takabayashi, Mutsuaki Edama, Emi Nakamura, Erika Yokoyama, Chiaki Kanaya, Masayoshi Kubo
BACKGROUND: Examining coordination between segments is essential for prevention and treatment of injuries. However, traditional methods such as ratio, cross-correlation technique, and angle-time plot may not provide a complete understanding of intersegmental coordination. The present study aimed to quantify the coordination among the rearfoot, midfoot, and forefoot segments during walking. METHODS: Twenty healthy young men walked barefoot on a treadmill. Reflective markers were fixed to their right shank and foot based on the Leardini foot model...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29020959/configurable-wearable-sensing-and-vibrotactile-feedback-system-for-real-time-postural-balance-and-gait-training-proof-of-concept
#10
Junkai Xu, Tian Bao, Ung Hee Lee, Catherine Kinnaird, Wendy Carender, Yangjian Huang, Kathleen H Sienko, Peter B Shull
BACKGROUND: Postural balance and gait training is important for treating persons with functional impairments, however current systems are generally not portable and are unable to train different types of movements. METHODS: This paper describes a proof-of-concept design of a configurable, wearable sensing and feedback system for real-time postural balance and gait training targeted for home-based treatments and other portable usage. Sensing and vibrotactile feedback are performed via eight distributed, wireless nodes or "Dots" (size: 22...
October 11, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29016337/the-multifactorial-epidemiology-of-blackwater-fever
#11
G Dennis Shanks
Blackwater fever is a massive hemolytic event usually occurring in the context of repeated falciparum malaria infections and intermittent quinine use. Its etiology is poorly understood, and it is rarely seen today. Historical epidemiological observations from the 20th century demonstrated variable patterns in prisoners in Andaman Islands, refugees in Macedonia, canal workers in Panama, expatriates in Rhodesia, and Second World War soldiers. Rates of blackwater fever per 1,000 malaria cases varied over two orders of magnitude...
October 2, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28986455/genomic-triangulation-and-coverage-analysis-in-whole-exome-sequencing-based-molecular-autopsies
#12
Garrett W Shanks, David J Tester, Sneha Nishtala, Jared M Evans, Michael J Ackerman
BACKGROUND: WEMA (Whole-Exome Molecular Autopsy) and surveillance of cardiac channelopathy and cardiomyopathy genes represents the latest molecular autopsy for sudden death in the young (SDY). To date, the majority of WEMA has been performed on the SDY case only. METHODS AND RESULTS: We performed whole-exome sequencing and nucleotide-level coverage analysis on 28 SDY cases (18.4±7.8 years) and their parents to determine the inheritance patterns of ultrarare, nonsynonymous variants in 99 sudden death-susceptibility genes...
October 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28979189/uncorrelated-neural-firing-in-mouse-visual-cortex-during-spontaneous-retinal-waves
#13
Matthew T Colonnese, Jing Shen, Yasunobu Murata
Synchronous firing among the elements of forming circuits is critical for stabilization of synapses. Understanding the nature of these local network interactions during development can inform models of circuit formation. Within cortex, spontaneous activity changes throughout development. Unlike the adult, early spontaneous activity occurs in discontinuous population bursts separated by long silent periods, suggesting a high degree of local synchrony. However, whether the micro-patterning of activity within early bursts is unique to this early age and specifically tuned for early development is poorly understood, particularly within the column...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28978243/the-application-of-inertial-measurements-unit-for-the-clinical-evaluation-and-assessment-of-gait-events
#14
Shiva Sharif Bidabadi, Iain Murray, Gabriel Yin Foo Lee
Foot drop is one of the common gait abnormalities which are difficult to detect, diagnose and evaluate. While various gait monitoring systems are available, many are computationally expensive and difficult to implement outside laboratory environments. This study introduces an in-house designed system based on inertial measurement units to capture the gait symptoms, specifically in the case of foot drop symptoms. The system specification and communication results, as well as filtering methods are discussed. Also, the pitch angle of thigh, shank and foot from a subject with no reported foot problem have been compared (gathered from identical equipment under similar conditions) to the same angle from a foot drop subject...
October 5, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28974593/endocrine-abnormalities-in-lithium-toxicity
#15
Gabriella Shanks, Vinita Mishra, Stanka Nikolova
Lithium toxicity can manifest as a variety of biochemical -abnormalities. This case report describes a patient -presenting to the emergency department with neuropsychiatric -symptoms on a background of bipolar disorder, for which she was prescribed lithium for 26 years previously. Cases of lithium toxicity are rare but can be severe and this case report -demonstrates to clinicians that they must be thorough in investigating patients with lithium toxicity, as there are many potential abnormalities that can manifest concurrently...
October 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28973097/association-between-fungal-contamination-and-eye-bank-prepared-endothelial-keratoplasty-tissue-temperature-dependent-risk-factors-and-antifungal-supplementation-of-optisol-gentamicin-and-streptomycin
#16
Kimberly M Brothers, Robert M Q Shanks, Susan Hurlbert, Regis P Kowalski, Elmer Y Tu
Importance: Fungal contamination and infection from donor tissues processed for endothelial keratoplasty is a growing concern, prompting analysis of donor tissues after processing. Objective: To determine whether eyebank-processed endothelial keratoplasty tissue is at higher risk of contamination than unprocessed tissue and to model eyebank processing with regard to room temperature exposure on Candida growth in optisol-gentamicin and streptomycin (GS) with and without antifungal supplementation...
September 28, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28965158/influence-of-non-invasive-blood-pressure-measurement-intervals-on-the-occurrence-of-intra-operative-hypotension
#17
Grant H Kruger, Amy Shanks, Sachin Kheterpal, Tyler Tremper, Chi-Jung Chiang, Robert E Freundlich, James M Blum, Albert J Shih, Kevin K Tremper
The American Society of Anesthesiologists Standards for Basic Monitoring recommends blood pressure (BP) measurement every 5 min. Research has shown distractions or technical factors can cause prolonged measurement intervals exceeding 5 min. We investigated the relationship between prolonged non-invasive BP (NIBP) measurement interval and the incidence of hypotension, detected post-interval. Our secondary outcome was to determine independent predictors of these prolonged NIBP measurement intervals. Retrospective data were analyzed from 139,509 general anesthesia cases from our institution's Anesthesia Information Management System (AIMS)...
September 30, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28963938/coupling-motion-between-rearfoot-and-hip-and-knee-joints-during-walking-and-single-leg-landing
#18
Yuta Koshino, Masanori Yamanaka, Yuya Ezawa, Takumi Okunuki, Tomoya Ishida, Mina Samukawa, Harukazu Tohyama
The objective of the current study was to investigate the kinematic relationships between the rearfoot and hip/knee joint during walking and single-leg landing. Kinematics of the rearfoot relative to the shank, knee and hip joints during walking and single-leg landing were analyzed in 22 healthy university students. Kinematic relationships between two types of angular data were assessed by zero-lag cross-correlation coefficients and coupling angles, and were compared between joints and between tasks. During walking, rearfoot eversion/inversion and external/internal rotation were strongly correlated with hip adduction/abduction (R=0...
September 22, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28963042/behavioral-phenotypes-and-neurobiological-mechanisms-in-the-shank1-mouse-model-for-autism-spectrum-disorder-a-translational-perspective
#19
REVIEW
A Özge Sungur, Rainer K W Schwarting, Markus Wöhr
Autism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental disorders, characterized by early-onset deficits in social behavior and communication across multiple contexts, together with restricted, repetitive patterns of behavior, interests, or activities. ASD is among the most heritable neuropsychiatric conditions with heritability estimates higher than 80%, and while available evidence points to a complex set of genetic factors, the SHANK (also known as ProSAP) gene family has emerged as one of the most promising candidates...
September 26, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28961404/detection-of-breed-specific-copy-number-variations-in-domestic-chicken-genome
#20
Saeed S Sohrabi, Mohammadreza Mohammadabadi, Dong-Dong Wu, Ali Esmailizadeh
Copy number variations (CNVs) are important large scale variants that are widespread in the genome and may contribute to phenotypic variation. Detection and characterization of CNVs can provide new insights into the genetic basis of important traits. Here, we performed whole genome short read sequence analysis to identify CNVs in two indigenous and commercial chicken breeds and evaluate the impact of the identified CNVs on breed specific traits. After filtration, a total of 12955 CNVs spanning (on average) about 9...
September 29, 2017: Genome Génome / Conseil National de Recherches Canada
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