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https://www.readbyqxmd.com/read/29166466/neurological-complications-of-solid-organ-transplantation
#1
José Luiz Pedroso, Lívia Almeida Dutra, Pedro Braga-Neto, Agessandro Abrahao, João Brainer Clares de Andrade, Gabriel Lopes da Silva, Laila Almeida Viana, José Osmar Medina Pestana, Orlando G Barsottini
Solid organ transplantation is a significant development in the treatment of chronic kidney, liver, heart and lung diseases. This therapeutic approach has increased patient survival and improved quality of life. New surgical techniques and immunosuppressive drugs have been developed to achieve better outcomes. However, the variety of neurological complications following solid organ transplantation is broad and carries prognostic significance. Patients may have involvement of the central or peripheral nervous system due to multiple causes that can vary depending on time of onset after the surgical procedure, the transplanted organ, and the intensity and type of immunosuppressive therapy...
October 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29150805/aspergillus-terreus-treated-rice-straw-suppresses-methane-production-and-enhances-feed-digestibility-in-goats
#2
P Mohd Azlan, M F Jahromi, M O Ariff, M Ebrahimi, S C L Candyrine, J B Liang
The objectives of this study were to test the efficacy of producing lovastatin in rice straw treated with Aspergillus terreus in larger laboratory scale following the procedure previously reported and to investigate the effectiveness of the treated rice straw containing lovastatin on methane mitigation in goats. The concentration of lovastatin in the treated rice straw was 0.69 ± 0.05 g/kg dry matter (DM) rice straw. Our results showed that supplementation of lovastatin at 4.14 mg/kg BW reduced methane production by 32% while improving the DM digestibility by 13% (P < 0...
November 17, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29150680/potential-landscape-of-high-dimensional-nonlinear-stochastic-dynamics-with-large-noise
#3
Ying Tang, Ruoshi Yuan, Gaowei Wang, Xiaomei Zhu, Ping Ao
Quantifying stochastic processes is essential to understand many natural phenomena, particularly in biology, including the cell-fate decision in developmental processes as well as the genesis and progression of cancers. While various attempts have been made to construct potential landscape in high dimensional systems and to estimate transition rates, they are practically limited to the cases where either noise is small or detailed balance condition holds. A general and practical approach to investigate real-world nonequilibrium systems, which are typically high-dimensional and subject to large multiplicative noise and the breakdown of detailed balance, remains elusive...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29148185/eye-for-positive-signs-a-practical-approach-to-childhood-eye-disease
#4
Antony Bedggood
No abstract text is available yet for this article.
November 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29135263/photoredox-divergent-1-2-difunctionalization-of-alkenes-with-gem-dibromides
#5
Jian Cheng, Yixiang Cheng, Jin Xie, Chengjian Zhu
The redox neutral photocatalytic divergent radical 1,2-difunctionalization of a wide array of structurally varied alkenes with gem-dibromides is presented. On the basis of the electronic effect of alkenes, predictable 1,2-carboxygenation and 1,2-carbohalogenation of alkenes are readily available regardless of steric effect. This protocol affords a practical approach to the biologically important furan skeleton. It is distinguished by good regioselectivity, good functional group compatibility, and late-stage modification and thus signifies an important step forward to divergent radical difunctionalization of alkenes...
November 14, 2017: Organic Letters
https://www.readbyqxmd.com/read/29132575/acute-management-of-the-traumatically-injured-pelvis
#6
REVIEW
Steven Skitch, Paul T Engels
Severe pelvic trauma is a challenging condition. The pelvis can create multifocal hemorrhage that is not easily compressible nor managed by traditional surgical methods such as tying off a blood vessel or removing an organ. Its treatment often requires reapproximation of bony structures, damage control resuscitation, assessment for associated injuries, and triage of investigations, as well as multimodality hemorrhage control (external fixation, preperitoneal packing, angioembolization, REBOA [resuscitative endovascular balloon occlusion of the aorta]) by multidisciplinary trauma specialists (general surgeons, orthopedic surgeons, endovascular surgeons/interventional radiologists)...
February 2018: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/29126451/acceleration-sensors-in-abdominal-wall-position-as-a-non-invasive-approach-to-detect-early-breathing-alterations-induced-by-intolerance-of-increased-airway-resistance
#7
Thomas Breuer, Christian S Bruells, Rolf Rossaint, Henning Steffen, Catherine Disselhorst-Klug, Michael Czaplik, Norbert Zoremba
BACKGROUND: Early detection of respiratory overload is crucial to mechanically ventilated patients, especially during phases of spontaneous breathing. Although a diversity of methods and indices has been established, there is no highly specific approach to predict respiratory failure. This study aimed to evaluate acceleration sensors in abdominal and thoracic wall positions to detect alterations in breathing excursions in a setting of gradual increasing airway resistance. METHODS: Twenty-nine healthy volunteers were committed to a standardized protocol of a two-minutes step-down spontaneous breathing on a 5 mm, 4 mm and then 3 mm orally placed endotracheal tube...
November 10, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29121284/neuropathic-pain-in-cancer-systematic-review-performance-of-screening-tools-and-analysis-of-symptom-profiles
#8
M R Mulvey, E G Boland, D Bouhassira, R Freynhagen, J Hardy, M J Hjermstad, S Mercadante, C Pérez, M I Bennett
Background: The objectives of this study were to evaluate the methodological quality of rigorous neuropathic pain assessment tools in applicable clinical studies, and determine the performance of screening tools for identifying neuropathic pain in patients with cancer. Methods: Systematic literature search identified studies reporting use of Leeds Assessment of Neuropathic Symptoms and Signs (LANSS), Douleur Neuropathique en 4 (DN4) or painDETECT (PDQ) in cancer patients with a clinical diagnosis of neuropathic or not neuropathic pain...
October 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29116890/a-test-and-not-treat-strategy-for-onchocerciasis-in-loa-loa-endemic-areas
#9
Joseph Kamgno, Sébastien D Pion, Cédric B Chesnais, Matthew H Bakalar, Michael V D'Ambrosio, Charles D Mackenzie, Hugues C Nana-Djeunga, Raceline Gounoue-Kamkumo, Guy-Roger Njitchouang, Philippe Nwane, Jules B Tchatchueng-Mbouga, Samuel Wanji, Wilma A Stolk, Daniel A Fletcher, Amy D Klion, Thomas B Nutman, Michel Boussinesq
Background Implementation of an ivermectin-based community treatment strategy for the elimination of onchocerciasis or lymphatic filariasis has been delayed in Central Africa because of the occurrence of serious adverse events, including death, in persons with high levels of circulating Loa loa microfilariae. The LoaScope, a field-friendly diagnostic tool to quantify L. loa microfilariae in peripheral blood, enables rapid, point-of-care identification of persons at risk for serious adverse events. Methods A test-and-not-treat strategy was used in the approach to ivermectin treatment in the Okola health district in Cameroon, where the distribution of ivermectin was halted in 1999 after the occurrence of fatal events related to L...
November 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29112921/a-novel-fungal-arsenic-methyltransferase-waarsm-reduces-grain-arsenic-accumulation-in-transgenic-rice-oryza-sativa-l
#10
Shikha Verma, Pankaj Kumar Verma, Alok Kumar Meher, Amit Kumar Bansiwal, Rudra Deo Tripathi, Debasis Chakrabarty
Rice (Oryza sativa L.) grown on arsenic-containing soil and water become a primary dietary source of arsenic and pose a significant health risk. Gene modification is an important and practical approach to reduce arsenic accumulation in rice grains. Here, we reported a WaarsM gene of soil fungus Westerdykella aurantiaca, expressed in rice able to convert toxic inorganic arsenicals to methylated arsenic species, therefore, reduce arsenic accumulation in rice grains. In response to arsenic treatment in hydroponics, WaarsM expressing transgenic lines showed a marked increase in arsenic resistance and reduces its accumulation compared to NT...
October 28, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29105896/practical-approach-to-axially-chiral-biaryl-amino-alcohols-via-organocatalytic-atroposelective-arylation-of-2-naphthylamines
#11
Bin Tan, Ye-Hui Chen, Liang-Wen Qi, Fang Fang
The first phosphoric acid-catalyzed direct arylation of 2-naphthylamines with iminoquinones for the atroposelective synthesis of axially chiral biaryl-amino-alcohols has been developed. This reaction features a highly functional group tolerant route to the rapid construction of enantioenriched axially chiral biaryl-amino-alcohols with good results. This represents a rare example of 2-naphthylamines acting as nucleophiles in organocatalytic enantioselective transformation. Furthermore, the products which have various halogen atoms offer access to structurally diverse axially chiral amino alcohols through further transformation...
November 5, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29105685/-cardiogenic-shock-from-pharmacological-treatment-to-mechanical-circulatory-support
#12
Ilaria Battistoni, Marco Marini, Alberto Lavorgna, Fabio Vagnarelli, Fabiana Lucà, Emilia Biscottini, Giorgio Caretta, Vincenza Procaccini, Letizia Riva, Gabriele Vianello, Massimo Iacoviello, Renata De Maria, Alessandro Navazio, Nadia Aspromonte, Andrea Di Lenarda, Michele Massimo Gulizia, Serafina Valente
Cardiogenic shock (CS) is a state of critical end-organ hypoperfusion due to reduced cardiac output, despite adequate filling status. The development of multiorgan dysfunction is believed to be the major contributor to the high early mortality. Little evidence exists as to which vasopressor or inotrope should best be used for early treatment; however, customized pharmacological therapy, tailored on hemodynamic monitoring, is essential to achieve normal peripheral perfusion. Moreover, an increasing number of mechanical circulatory support devices are available for hemodynamic support in patients with CS but, at present, data derived from randomized clinical trials on the effectiveness, safety, differential indications for mechanical support devices, and optimal implant timing are limited...
October 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29103801/guiding-principles-for-use-of-newer-biologics-and-bronchial-thermoplasty-for-patients-with-severe-asthma
#13
Michael S Blaiss, Mario Castro, Bradley E Chipps, Myron Zitt, Reynold A Panettieri, Michael B Foggs
BACKGROUND: Severe asthma poses significant disease-related and economic burdens in the United States. Challenges in practice include how to define "severe asthma" for a given patient, knowing which are the right tests to perform and when, and having a better understanding of a patient's asthma phenotype. Furthermore, current guidelines do not address a clear, practical approach to treatment that is based on a patient's asthma phenotype. OBJECTIVE: To develop a consensus on the definition of severe asthma, the role of biomarkers and phenotyping severe asthma, and the use of newer biologic therapies and bronchial thermoplasty to help guide practicing clinicians...
November 2, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29103535/practical-approach-to-the-flattened-duodenal-biopsy
#14
REVIEW
Thomas C Smyrk
Celiac disease features duodenal intraepithelial lymphocytosis with or without villous atrophy. Lymphocytosis without villous atrophy will be proven to represent celiac disease in 10% to 20% of cases. The differential diagnosis is broad: Helicobacter pylori gastritis, NSAID injury and bacterial overgrowth are considerations. Lymphocytosis with villous atrophy is very likely to be celiac disease, but there are mimics to consider, including collagenous sprue, tropical sprue, drug injury, and common variable immunodeficiency...
December 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/29102577/a-practical-approach-to-radiation-protection-for-cardiac-catheterization-laboratory-staff
#15
EDITORIAL
Kenneth A Fetterly, Malcom R Bell
No abstract text is available yet for this article.
October 26, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29100261/a-practical-approach-to-neonatal-opiate-withdrawal-syndrome
#16
Lori A Devlin, Jonathan M Davis
No abstract text is available yet for this article.
November 3, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29098553/practical-approaches-to-diagnosing-treating-and-preventing-hypoglycemia-in-diabetes
#17
REVIEW
Kathryn Evans Kreider, Katherine Pereira, Blanca I Padilla
Hypoglycemia in individuals with diabetes can increase the risk of morbidity and all-cause mortality in this patient group, particularly in the context of cardiovascular impairment, and can significantly decrease the quality of life. Hypoglycemia can present one of the most difficult aspects of diabetes management from both a patient and healthcare provider perspective. Strategies used to reduce the risk of hypoglycemia include individualizing glucose targets, selecting the appropriate medication, modifying diet and lifestyle and applying diabetes technology...
December 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29098306/-differentiated-surgical-approach-for-adenocarcinoma-of-the-gastroesophageal-junction
#18
REVIEW
W Schröder, R Lambertz, R van Hillegesberger, C Bruns
For adenocarcinoma of the gastroesophageal junction (GEJ) the classification of Siewert with its three subtypes is well established as a practical approach to surgical treatment. Transthoracic esophagectomy with gastric tube formation is generally accepted as the surgical standard for adenocarcinoma of the distal esophagus (GEJ type I). Intrathoracic esophagogastrostomy has become the most frequently used anastomotic technique (Ivor Lewis esophagectomy). Both the abdominal and thoracic part can be safely performed with a minimally invasive access...
November 2, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29097554/restless-legs-syndrome-clinical-features-diagnosis-and-a-practical-approach-to-management
#19
REVIEW
Subhashie Wijemanne, William Ondo
Restless legs syndrome (RLS) is a chronic neurological disorder that interferes with rest and sleep. It has a wide spectrum of symptom severity, and treatment is started when symptoms become bothersome. Dopamine agonists and calcium channel apha-2-delta antagonists (gabapentin, gabapentin enacarbil and pregabalin) are first-line treatments; calcium channel alpha-2-deltas are preferred over dopamine agonists because they give less augmentation, a condition with symptom onset earlier in the day and intensification of RLS symptoms...
December 2017: Practical Neurology
https://www.readbyqxmd.com/read/29095186/nerve-repair-manual-a-practical-approach-to-injuries-and-repair-in-the-brachial-plexus-and-upper-extremity
#20
Brian D Rinker
No abstract text is available yet for this article.
October 31, 2017: Annals of Plastic Surgery
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