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https://www.readbyqxmd.com/read/28101910/a-practical-approach-to-vaccination-of-patients-with-autoimmune-inflammatory-rheumatic-diseases-in-australia
#1
REVIEW
Peter Kk Wong, Hanish Bagga, Claire Barrett, Paddy Hanrahan, Doug Johnson, Amel Katrib, Karin Leder, Mona Marabani, Peta Pentony, John Riordan, Ray White, Laurel Young
Autoimmune inflammatory rheumatic diseases (AIIRD) such as rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are often complicated by infection, which results in significant morbidity and mortality. The increased risk of infection is probably due to a combination of immunosuppressive effects of the AIIRD, comorbidities, and the use of immunosuppressive conventional synthetic disease modifying anti-rheumatic drugs (DMARDS) and more recently, targeted synthetic DMARDS and biologic DMARDS which block specific pro-inflammatory enzymes, cytokines or cell types...
January 19, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28101750/mortuary-operations-following-mass-fatality-natural-disasters-a-review
#2
REVIEW
Madelyn Anderson, Jodie Leditschke, Richard Bassed, Stephen M Cordner, Olaf H Drummer
This is a critical review to discuss the best practice approaches to mortuary operations in preparation for and the response to natural, mass fatality, disaster events, as identified by a review of published articles. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P) Statement guided the identification of potential articles to use in this critical review. Subsequent searches were also conducted to identify articles relating to heat wave, and flood mortality. All identified peer-reviewed studies published in English which discussed the preparation and response of mortuaries to mass fatality natural disasters occurring in developed countries were included...
January 18, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28097306/universal-trichloroacetic-acid-peel-technique-for-light-and-dark-skin
#3
Nabil Fanous, Shadi Zari
Importance: Despite their great potential, medium and deep trichloroacetic acid peels are underused in light-skinned patients and are rarely used in darker-skinned patients because of the widespread fear of pigmentary complications and scarring. This concern has led many physicians to opt for the use of lighter types of peels (glycolic acid peel, Jessner peel, etc) and different lasers and intense light technologies. Trichloroacetic acid peels have been described in numerous publications...
January 12, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/28095592/a-practical-approach-to-address-uncertainty-in-stakeholder-deliberations
#4
Robin Gregory, Ralph L Keeney
This article addresses the difficulties of incorporating uncertainty about consequence estimates as part of stakeholder deliberations involving multiple alternatives. Although every prediction of future consequences necessarily involves uncertainty, a large gap exists between common practices for addressing uncertainty in stakeholder deliberations and the procedures of prescriptive decision-aiding models advanced by risk and decision analysts. We review the treatment of uncertainty at four main phases of the deliberative process: with experts asked to describe possible consequences of competing alternatives, with stakeholders who function both as individuals and as members of coalitions, with the stakeholder committee composed of all stakeholders, and with decisionmakers...
January 17, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28087484/inhibition-of-bacterial-adhesion-and-biofilm-formation-by-dual-functional-textured-and-nitric-oxide-releasing-surfaces
#5
Li-Chong Xu, Yaqi Wo, Mark E Meyerhoff, Christopher A Siedlecki
: In separate prior studies, physical topographic surface modification or nitric oxide (NO) release has been demonstrated to each be an effective approach to inhibit and control bacterial adhesion and biofilm formation on polymeric surfaces. Such approaches can prevent biomaterial-associated infection without causing the antibiotic resistance of the strain. In this work, both techniques were successfully integrated and applied to a polyurethane (PU) biomaterial surface that bears ordered pillar topographies (400/400 nm and 500/500 nm patterns) at the top surface and a S-nitroso-N-acetylpenicillamine (SNAP, NO donor) doped sub-layer in the middle, via a soft lithography two-stage replication process...
January 10, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28074623/characterization-and-application-of-a-self-aspirating-electrospray-source-with-pneumatic-assisted-ionization
#6
Quan Yu, Jianchao Zhang, Kai Ni, Xiang Qian, Xiaohao Wang
A single gas-assisted electrospray ion source developed for ambient mass spectrometry is introduced in this paper. Simultaneous self-aspiration and electrospray could be achieved by using a constant sheath gas flow supplied from a mini air pump. A gas dynamic study of the spray module is carried out for structural optimization. The entire device exhibits a simplified design and has been systematically characterized through both simulated and experimental investigations. According to the results, the ion source exhibited satisfactory stability and the ability for quantitative operation in routine electrospray ionization mass spectrometry...
January 11, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28069628/cushing-s-syndrome-a-practical-approach-to-diagnosis-and-differential-diagnoses
#7
Joseph M Pappachan, Christian Hariman, Mahamood Edavalath, Julian Waldron, Fahmy W Hanna
Diagnosis of Cushing's syndrome (CS) and identification of the aetiology of hypercortisolism can be challenging. The Endocrine Society clinical practice guidelines recommends one of the four tests for initial screening of CS, namely, urinary-free cortisol, late night salivary cortisol, overnight dexamethasone suppression test or a longer low-dose dexamethasone suppression test, for 48 hours. Confirmation and localisation of CS requires additional biochemical and radiological tests. Radiological evaluation involves different imaging modalities including MRI with or without different radio-nuclear imaging techniques...
January 9, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28068789/pragmatic-trial-of-video-education-in-nursing-homes-the-design-and-rationale-for-a-pragmatic-cluster-randomized-trial-in-the-nursing-home-setting
#8
Vincent Mor, Angelo E Volandes, Roee Gutman, Constantine Gatsonis, Susan L Mitchell
Background/Aims Nursing homes are complex healthcare systems serving an increasingly sick population. Nursing homes must engage patients in advance care planning, but do so inconsistently. Video decision support tools improved advance care planning in small randomized controlled trials. Pragmatic trials are increasingly employed in health services research, although not commonly in the nursing home setting to which they are well-suited. This report presents the design and rationale for a pragmatic cluster randomized controlled trial that evaluated the "real world" application of an Advance Care Planning Video Program in two large US nursing home healthcare systems...
January 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28055826/system-on-chip-considerations-for-heterogeneous-integration-of-cmos-and-fluidic-bio-interfaces
#9
Timir Datta-Chaudhuri, Elisabeth Smela, Pamela A Abshire
CMOS chips are increasingly used for direct sensing and interfacing with fluidic and biological systems. While many biosensing systems have successfully combined CMOS chips for readout and signal processing with passive sensing arrays, systems that co-locate sensing with active circuits on a single chip offer significant advantages in size and performance but increase the complexity of multi-domain design and heterogeneous integration. This emerging class of lab-on-CMOS systems also poses distinct and vexing technical challenges that arise from the disparate requirements of biosensors and integrated circuits (ICs)...
December 2016: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28048806/su-g-iep4-05-experience-with-a-practical-approach-to-the-release-of-radioactive-patients-from-radiation-safety-isolation
#10
R Wendt, W Erwin, A Fisher, S Jones, S Jimenez, F Wong, A Jessop
PURPOSE: The radioactive patient releases of the nuclear medicine department in a large cancer center were analyzed to compare the estimated doses to others to the regulatory limit and institutional targets and to gauge how onerous the patients' instructions were. METHODS: In-house software that implements the NUREG 1556 approach and further considers fellow travelers, children and pregnant women and members of the public following Siegel, et al., is used to calculate release timing and to provide patients with individualized instructions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027577/a-practical-approach-to-nutritional-screening-and-assessment-in-cirrhosis
#11
REVIEW
Puneeta Tandon, Maitreyi Raman, Marina Mourtzakis, Manuela Merli
Malnutrition is one of the most common complications of cirrhosis, associated with an increased risk of morbidity and mortality. As a potentially modifiable condition, it is of particular relevance to identify malnourished patients so that nutritional therapy can be instituted. Nutrition screening and assessment are currently performed infrequently in patients with cirrhosis. The reasons for this are multifactorial including the absence of a validated "rapid" screening tool, multiple definitions of what constitutes malnutrition, and challenges with interpreting body composition and laboratory results in the setting of volume overload and liver dysfunction...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28003136/practical-approaches-to-approximating-mtf-and-nps-in-ct-with-an-example-application-to-task-based-observer-studies
#12
Robert Bujila, Annette Fransson, Gavin Poludniowski
PURPOSE: To investigate two methods of approximating the Modulation Transfer Function (MTF) and Noise Power Spectrum (NPS) in computed tomography (CT) for a range of scan parameters, from limited image acquisitions. METHODS: The two methods consist of 1) using a linear systems approach to approximate the NPS for different filtered backprojection (FBP) kernels with a filter function derived from the kernel ratio of determined MTFs and 2) using an empirical fitted model to approximate the MTF and NPS...
December 18, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/28000208/when-to-initiate-immunoglobulin-replacement-therapy-igrt-in-antibody-deficiency-a-practical-approach
#13
REVIEW
Stephen Jolles, Helen Chapel, Jiri Litzman
Primary antibody deficiencies (PAD) constitute the majority of all primary immunodeficiency diseases (PID) and immunoglobulin replacement forms the mainstay of therapy for many patients in this category. Secondary antibody deficiencies (SAD) represents a larger and expanding number of patients resulting from the use of a wide range of immunosuppressive therapies, in particular those targeting B cells, and may also result from renal or gastrointestinal immunoglobulin losses. While there are clear similarities between primary and secondary antibody deficiencies, there are also significant differences...
December 21, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27997995/cimpact-now-the-consortium-to-inform-molecular-and-practical-approaches-to-cns-tumor-taxonomy-a-new-initiative-in-advancing-nervous-system-tumor-classification
#14
David N Louis, Ken Aldape, Daniel J Brat, David Capper, David W Ellison, Cynthia Hawkins, Werner Paulus, Arie Perry, Guido Reifenberger, Dominique Figarella-Branger, Pieter Wesseling, Tracy T Batchelor, J Gregory Cairncross, Stefan M Pfister, Stefan Rutkowski, Michael Weller, Wolfgang Wick, Andreas von Deimling
No abstract text is available yet for this article.
December 20, 2016: Brain Pathology
https://www.readbyqxmd.com/read/27984236/duodenal-neoplasms-of-gastric-phenotype-an-immunohistochemical-and-genetic-study-with-a-practical-approach-to-the-classification
#15
Risa Hida, Hidetaka Yamamoto, Minako Hirahashi, Reiko Kumagai, Kenichi Nishiyama, Toshihiro Gi, Motohiro Esaki, Takanari Kitazono, Yoshinao Oda
Duodenal neoplasm of gastric phenotype (DNGP) is very rare, and details of its histopathologic, genetic, and biological features are still unclear. Frequent gene mutations in GNAS, KRAS, and APC have been reported in pyloric gland adenomas and fundic gland-type neoplasms (initially reported as low-grade adenocarcinomas) of the stomach. Here we retrospectively analyzed 16 cases of extra-ampullary DNGP (benign to malignant), and we examined the mucin immunoprofile and oncogene mutations (GNAS, KRAS, APC, BRAF, and CTNNB1)...
December 14, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27977306/nasal-and-olfactory-deposition-with-normal-and-bidirectional-intranasal-delivery-techniques-in-vitro-tests-and-numerical-simulations
#16
Jinxiang Xi, Zhaoxuan Wang, Danielle Nevorski, Thomas White, Yue Zhou
BACKGROUND: Intranasal delivery protocols that can effectively deposit drugs to the olfactory region are severely lacking. Furthermore, it is still challenging to quantify nasal deposition on a regional or local basis, which is crucial in assessing the performance of targeted olfactory drug delivery. OBJECTIVES: To visually and quantitatively compare drug depositions in the nose and olfactory region with normal and bidirectional breathing patterns with vibrating mesh and jet nebulizers...
December 15, 2016: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/27951576/future-trends-in-vascular-access-creation
#17
Surendra Shenoy
Delivery of a prescribed dialysis dose, which is critical for longevity on hemodialysis, is directly dependent on vascular access (VA). However, VA is fraught with high failure rates and has room for innovation. Arteriovenous fistula (AVF), considered the 'best choice', has a high 'failure to mature' rate. Arteriovenous grafts (AVGs) are considered when patients are poor candidates for or have failed AVF, but have a high incidence of infections and thrombosis. Due to associated morbidity and mortality from complications, central venous catheters are considered only as 'bridging short-term access' when there is an urgent need for dialysis...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/27939035/two-step-egg-introduction-for-prevention-of-egg-allergy-in-high-risk-infants-with-eczema-petit-a-randomised-double-blind-placebo-controlled-trial
#18
Osamu Natsume, Shigenori Kabashima, Junko Nakazato, Kiwako Yamamoto-Hanada, Masami Narita, Mai Kondo, Mayako Saito, Ai Kishino, Tetsuya Takimoto, Eisuke Inoue, Julian Tang, Hiroshi Kido, Gary W K Wong, Kenji Matsumoto, Hirohisa Saito, Yukihiro Ohya
BACKGROUND: Evidence is accumulating that early consumption is more beneficial than is delayed introduction as a strategy for primary prevention of food allergy. However, allergic reactions caused by early introduction of such solid foods have been a problematic issue. We investigated whether or not early stepwise introduction of eggs to infants with eczema combined with optimal eczema treatment would prevent egg allergy at 1 year of age. METHODS: In this randomised, double-blind, placebo-controlled trial, we enrolled infants 4-5 months of age with eczema from two centres in Japan...
December 7, 2016: Lancet
https://www.readbyqxmd.com/read/27938817/acral-manifestations-of-soft-tissue-tumors
#19
Kristen M Paral, Vesna Petronic-Rosic
This group of biologically diverse entities is united by topographic localization to the hands and feet. Categorizing tumors by body site narrows the differential into a short list of possibilities that can facilitate accurate and rapid diagnosis. The goal of this review is to provide a practical approach to soft tissue tumors of acral locations for clinicians, pathologists, and researchers alike. What ensues in the following text is that tight coupling of the clinical picture and histopathologic findings should produce the correct diagnosis, or at least an abbreviated differential...
January 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/27929577/a-practical-approach-to-the-new-oral-anticoagulants-used-for-stroke-prevention-in-patients-with-atrial-fibrillation
#20
S Bashir, A Al-Mohammed, S Gupta
This review evaluates the research undertaken in the last six years on the use of new oral anticoagulants for stroke prevention in atrial fibrillation and provides evidence-based answers to common clinical questions. Two types of new oral anticoagulants - direct thrombin (IIa) inhibitors, and Xa inhibitors - are currently available. These drugs have similar pharmacokinetics and pharmacodynamics. They are more predictable than, though in many respects comparable to, warfarin. They do not require frequent laboratory tests, nor do they have a narrow therapeutic window...
June 2016: Journal of the Royal College of Physicians of Edinburgh
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