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https://www.readbyqxmd.com/read/29773496/reflections-on-methodical-approaches-to-hematopoietic-stem-cell-collection-in-children
#1
REVIEW
Claudia Del Fante, Jerard Seghatchian, Cesare Perotti
Pediatric peripheral blood stem cell collection (PBSC) is challenging because it has potentially more side effects than in adults due to the small body mass and unique physiology of children. The extracorporeal volume of the cell separator device, poor venous access and metabolic complications due to citrate toxicity are the main problems to face during PBSC collection. These aspects are more relevant in very low body weight (BW) children of 20 kg or lower. An efficient, experienced and well-prepared team of pediatricians, apheresis physicians and nurses, and physicians involved in CVC positioning is crucial to performing a safe PBSC collection...
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29772020/so-many-genes-so-little-time-a-practical-approach-to-divergence-time-estimation-in-the-genomic-era
#2
Stephen A Smith, Joseph W Brown, Joseph F Walker
Phylogenomic datasets have been successfully used to address questions involving evolutionary relationships, patterns of genome structure, signatures of selection, and gene and genome duplications. However, despite the recent explosion in genomic and transcriptomic data, the utility of these data sources for efficient divergence-time inference remains unexamined. Phylogenomic datasets pose two distinct problems for divergence-time estimation: (i) the volume of data makes inference of the entire dataset intractable, and (ii) the extent of underlying topological and rate heterogeneity across genes makes model mis-specification a real concern...
2018: PloS One
https://www.readbyqxmd.com/read/29768684/practical-approach-to-the-gastrointestinal-manifestations-of-cystic-fibrosis
#3
REVIEW
Rishi Bolia, Chee Y Ooi, Peter Lewindon, Jonathan Bishop, Sarath Ranganathan, Jo Harrison, Kristyn Ford, Natalie van der Haak, Mark R Oliver
Cystic fibrosis (CF) is the most common, life-shortening, genetic illness affecting children in Australia and New Zealand. The genetic abnormality results in abnormal anion transport across the apical membrane of epithelial cells in a number of organs, including the lungs, gastrointestinal tract, liver and genito-urinary tract. Thus, CF is a multi-system disorder that requires a multi-disciplinary approach. Respiratory disease is the predominant cause of both morbidity and mortality in patients with CF. However, there are significant and clinically relevant gastrointestinal, liver, pancreatic and nutritional manifestations that must be detected and managed in a timely and structured manner...
May 16, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29755601/a-practical-approach-to-the-percutaneous-treatment-of-iatrogenic-aorto-coronary-dissection
#4
George Kassimis, Tushar Raina
Catheter-induced aortic dissection during coronary angiography and Percutaneous Coronary Intervention (PCI) is a relatively infrequent, but potentially life-threatening complication. Patients who suffer this complication may require emergency aortic surgery. More recently, reports of treating the ostium of the dissected coronary artery have emerged as an alternative therapeutic option. In this article we describe two cases of extensive guide catheter induced dissection and their successful treatment using PCI and provide a concise overview of the available literature...
2018: Open Cardiovascular Medicine Journal
https://www.readbyqxmd.com/read/29752220/biomechanical-characteristics-of-biplane-multiplanar-tension-side-fixation-for-lapidus-fusion
#5
Paul Dayton, Daniel J Hatch, Robert D Santrock, Bret Smith
Although plating on the plantar, tension-side of the metatarsocuneiform joint provides an inherent biomechanical advantage for Lapidus arthrodesis, it has not been widely adopted owing to the morbidity associated with plantar application. To overcome these limitations, a modification to 90-90 locked biplanar plating was developed to provide the biomechanical advantages of multiplanar fixation and tension-side fixation, allowing application through a conventional incision. We tested the hypothesis that biplanar plating with tension-side fixation (low-profile straight dorsal plate and anatomic medial-plantar plate) would demonstrate improved mechanical stability compared with a previously tested 90-90 biplanar construct (small straight plate dorsally and medially) under cyclic loading...
May 8, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29739471/vitamin-d-in-pediatric-age-consensus-of-the-italian-pediatric-society-and-the-italian-society-of-preventive-and-social-pediatrics-jointly-with-the-italian-federation-of-pediatricians
#6
REVIEW
Giuseppe Saggese, Francesco Vierucci, Flavia Prodam, Fabio Cardinale, Irene Cetin, Elena Chiappini, Gian Luigi De' Angelis, Maddalena Massari, Emanuele Miraglia Del Giudice, Michele Miraglia Del Giudice, Diego Peroni, Luigi Terracciano, Rino Agostiniani, Domenico Careddu, Daniele Giovanni Ghiglioni, Gianni Bona, Giuseppe Di Mauro, Giovanni Corsello
Vitamin D plays a pivotal role in the regulation of calcium-phosphorus metabolism, particularly during pediatric age when nutritional rickets and impaired bone mass acquisition may occur.Besides its historical skeletal functions, in the last years it has been demonstrated that vitamin D directly or indirectly regulates up to 1250 genes, playing so-called extraskeletal actions. Indeed, recent data suggest a possible role of vitamin D in the pathogenesis of several pathological conditions, including infectious, allergic and autoimmune diseases...
May 8, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29737260/targeted-temperature-management-review-of-literature-and-guidelines-a-cardiologist-s-perspective
#7
Taimoor Hashim, Ranjith Shetty
Out of hospital cardiac arrest (OHCA) remains not an uncommon occurrence in USA and rest of the world. However, the survival to discharge following an episode of OHCA in adults is still very disappointing at around 10%. Several areas of improvement including education of general public in early Cardio Pulmonary resuscitation (CPR) by bystander, chest compression first, and improvement of Emergency Medical response time have had a positive effect in outcomes and survival but much still needs to be done. Recently new data has emerged with regards to post resuscitation care and mild induced hypothermia (now preferably called; targeted temperature management {TTM}) and several advances have been made...
May 7, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29732708/pharmacokinetic-modelling-and-validation-of-the-half-life-extension-needed-to-reduce-the-burden-of-infusions-compared-with-standard-factor-viii
#8
C Hermans, J Mahlangu, J Booth, H Schütz, E Santagostino, G Young, H-Y Lee, K N Steinitz-Trost, V Blanchette, E Berntorp
INTRODUCTION: Currently, no universally accepted definition of extended half-life (EHL) recombinant FVIII (rFVIII) exists. Identifying the minimum half-life extension ratio required for a reduction in dosing frequency compared with standard rFVIII could enable a more practical approach to decisions around prophylaxis with EHL rFVIII. AIM: To identify the half-life extension ratio required to decrease rFVIII dosing frequency by at least 1 day while maintaining the proportion of patients with plasma rFVIII levels above 1 IU/dL and without increasing the total weekly dose...
May 6, 2018: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/29731926/practical-approach-to-lung-health-experience-from-the-republic-of-macedonia
#9
Biljana Ilievska-Poposka, Maja Zakoska, Stefan Talevski
BACKGROUND: Among the adults and children aged 5 yrs who attend PHC settings, 20-30% seeks to care for respiratory symptoms. Over 80-90% of the respiratory patients suffer from acute respiratory infections (ARI), followed by chronic obstructive pulmonary diseases (COPD), asthma, and less frequently with pneumonia and tuberculosis (TB). To improve the quality of care in patients who seek assistance for respiratory symptoms in PHC settings and the efficiency of respiratory service delivery within healthcare systems, WHO has designated several initiatives among which one is PAL (Practical Approach to Lung Health)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731632/development-of-nanoemulsion-for-efficient-brain-parenteral-delivery-of-cefuroxime-designs-characterizations-and-pharmacokinetics
#10
Siti Norhawani Harun, Syafinaz Amin Nordin, Siti Salwa Abd Gani, Ahmad Fuad Shamsuddin, Mahiran Basri, Hamidon Bin Basri
Background and aim: Drugs that are effective against diseases in the central nervous system and reach the brain via blood must pass through the blood-brain barrier (BBB), a unique interface that protects against potential harmful molecules. This presents a major challenge in neuro-drug delivery. This study attempts to fabricate the cefuroxime-loaded nanoemulsion (CLN) to increase drug penetration into the brain when parenterally administered. Methods: The nanoemulsions were formulated using a high-pressure homogenization technique and were characterized for their physicochemical properties...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29726434/mobile-based-applications-and-functionalities-for-self-management-of-people-living-with-hiv
#11
Esmaeil Mehraeen, Reza Safdari, Niloofar Mohammadzadeh, Seyed Ahmad Seyedalinaghi, Siavash Forootan, Minoo Mohraz
BACKGROUND: Due to the chronicity of HIV/AIDS and the increased number of people living with HIV (PLWH), these people need the innovative and practical approaches to take advantage of high-quality healthcare services. The objectives of this scoping review were to identify the mobile-based applications and functionalities for self-management of people living with HIV. METHODS: We conducted a comprehensive search of PubMed, Scopus, Science direct, Web of Science and Embase databases for literature published from 2010 to 2017...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29722907/use-of-somatic-cell-banks-in-the-conservation-of-wild-felids
#12
REVIEW
Érika A Praxedes, Alana A Borges, Maria V O Santos, Alexsandra F Pereira
The conservation of biological resources is an interesting strategy for the maintenance of biodiversity, especially for wild felids who are constantly threatened with extinction. For this purpose, cryopreservation techniques have been used for the long-term storage of gametes, embryos, gonadal tissues, and somatic cells and tissues. The establishment of these banks has been suggested as a practical approach to the preservation of species and, when done in tandem with assisted reproductive techniques, could provide the means for reproducing endangered species...
May 3, 2018: Zoo Biology
https://www.readbyqxmd.com/read/29720490/implementing-a-quality-management-system-in-the-medical-microbiology-laboratory
#13
REVIEW
Roberta B Carey, Sanjib Bhattacharyya, Sue C Kehl, Larissa M Matukas, Michael A Pentella, Max Salfinger, Audrey N Schuetz
This document outlines a comprehensive practical approach to a laboratory quality management system (QMS) by describing how to operationalize the management and technical requirements described in the ISO 15189 international standard. It provides a crosswalk of the ISO requirements for quality and competence for medical laboratories to the 12 quality system essentials delineated by the Clinical and Laboratory Standards Institute. The quality principles are organized under three main categories: quality infrastructure, laboratory operations, and quality assurance and continual improvement...
July 2018: Clinical Microbiology Reviews
https://www.readbyqxmd.com/read/29720005/pulmonary-mycobacterial-spindle-cell-pseudotumor-a-report-of-3-cases-including-a-practical-approach-to-histopathologic-recognition-of-this-unusual-entity
#14
Katherine E Boylan, Brandon T Larsen, Brittany A Young, Erinn Downs-Kelly, Tanmay S Panchabhai, Earle S Collum, Leif Jensen, Lyska L Emerson
Mycobacterial spindle cell pseudotumor (MSP) is a rare benign spindle cell lesion containing acid-fact mycobacteria. These lesions are most commonly identified in the lymph nodes, skin, spleen, or bone marrow of immunocompromised patients and only rarely involve the lungs. We report 3 cases of pulmonary MSP, which include 2 patients who are known to be HIV-positive. The histopathological diagnosis of MSP in the lung lends itself to many challenges due to its rare incidence and its spindled tumor-like appearance...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29701881/pentameric-last-digit-preference-and-stage-border-avoidance-in-pathology-measurement
#15
Michael A den Bakker, Ronald A M Damhuis
Cancer treatment relies on accurate staging of which an essential aspect is determination of the size of a tumour. Measuring the size of a tumour in daily practice often proves problematic and results in rounding of values to approximate values. It has been shown that size values are more frequently reported with end digits of 0 or 5. We sought to determine if this observation holds true in our national cancer registry of breast and lung tumours. Data from patients with breast and lung cancer was retrieved from The Netherlands National Cancer Registry and analyzed for tumour size...
April 27, 2018: Histopathology
https://www.readbyqxmd.com/read/29700231/use-of-subcutaneous-and-intraperitoneal-administration-methods-to-facilitate-cassette-dosing-in-microdialysis-studies-in-rats
#16
Matthew R Durk, Gauri Deshmukh, Nicole Valle, Xiao Ding, Bianca M Liederer, Xingrong Liu
Microdialysis is a powerful technique allowing for real-time measurement of unbound drug concentrations in brain interstitial fluid (ISF) in conscious animals. Use of microdialysis in drug discovery is limited by high resource requirement and low throughput, but this may be improved by cassette dosing. Administering multiple compounds intravenously (IV) of diverse physiochemical properties, it is often very challenging and time-consuming to identify a vehicle that can dissolve all the compounds. To overcome this limitation, the present study explores the possibility of administering a cassette dose of 9 diverse compounds (carbamazepine, citalopram, desmethylclozapine, diphenhydramine, gabapentin, metoclopramide, naltrexone, quinidine, and risperidone) in suspension, rather than in solution, by intraperitoneal and subcutaneous routes, and determining if this is a viable option for assessing BBB penetration in microdialysis studies...
April 26, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29696308/role-of-mda5-and-interferon-i-in-dendritic-cells-for-t-cell-expansion-by-anti-tumor-peptide-vaccines-in-mice
#17
Hussein Sultan, Juan Wu, Takumi Kumai, Andres M Salazar, Esteban Celis
Cytotoxic T lymphocytes (CTLs) are effective components of the immune system capable of destroying tumor cells. Generation of CTLs using peptide vaccines is a practical approach to treat cancer. We have previously described a peptide vaccination strategy that generates vast numbers of endogenous tumor-reactive CTLs after two sequential immunizations (prime-boost) using poly-ICLC adjuvant, which stimulates endosomal toll-like receptor 3 (TLR3) and cytoplasmic melanoma differentiation antigen 5 (MDA5). Dendritic cells (DCs) play an important role not only in antigen presentation but are critical in generating costimulatory cytokines that promote CTL expansion...
April 25, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29687760/assessing-primary-care-data-quality
#18
Yvonne Mei Fong Lim, Maryati Yusof, Sheamini Sivasampu
Purpose The purpose of this paper is to assess National Medical Care Survey data quality. Design/methodology/approach Data completeness and representativeness were computed for all observations while other data quality measures were assessed using a 10 per cent sample from the National Medical Care Survey database; i.e., 12,569 primary care records from 189 public and private practices were included in the analysis. Findings Data field completion ranged from 69 to 100 per cent. Error rates for data transfer from paper to web-based application varied between 0...
April 16, 2018: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/29678334/evaluation-of-canine-sperm-and-management-of-semen-disorders
#19
REVIEW
Kara A Kolster
Semen evaluation of the male dog is a critical step in any canine infertility work-up. Assessment of total sperm count, sperm viability, and sperm morphology are the mainstay of breeding soundness evaluation. Adjunct tests, such as ultrasonography and serum hormone levels, can aid in diagnosis. Pharmacologic treatments, dietary supplements, and management practices may help improve breeding success in subfertile dogs. This article discusses a clinically practical approach to assessing sperm abnormalities and fertility in male dogs...
April 17, 2018: Veterinary Clinics of North America. Small Animal Practice
https://www.readbyqxmd.com/read/29676437/nerve-entrapment-syndromes-in-dermatology-review-and-practical-approach-to-treatment
#20
REVIEW
Samuel Zagarella
A good understanding of cutaneous nerve entrapment syndromes is important for physicians to provide early and accurate diagnosis and treatment. These syndromes have traditionally been managed with analgesics, antidepressants or antiepileptic medication but this approach is often inadequate and causes frequent adverse medication effects. With early diagnosis and treatment, many nerve entrapment syndromes can be successfully managed with physical, non-pharmacological approaches including stretches, exercises and physiotherapy...
April 20, 2018: Australasian Journal of Dermatology
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