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https://www.readbyqxmd.com/read/28220025/management-of-cancer-in-the-older-age-person-an-approach-to-complex-medical-decisions
#1
Maria Vallet-Regí, Miguel Manzano, Leocadio Rodriguez-Mañas, Marta Checa López, Matti Aapro, Lodovico Balducci
The management of cancer in older aged people is becoming a common problem due to the aging of the population. There are many variables determining the complex situation that are interconnected. Some of them can be assessed, such as risk of mortality and risk of treatment complications, but many others are still unknown, such as the course of disease, the host-related factors that influence cancer aggressiveness, and the phenotype heralding risk of permanent treatment-related damage.This article presents a dynamic and personalized approach to older people with cancer based on our experience on aging, cancer, and their biological interactions...
February 20, 2017: Oncologist
https://www.readbyqxmd.com/read/28215397/clinical-mimics-an-emergency-medicine-focused-review-of%C3%A2-influenza-mimics
#2
Erica Simon, Brit Long, Alex Koyfman
BACKGROUND: Influenza viruses are a significant cause of morbidity and mortality in the United States. Given the wide range of symptoms, emergency physicians must maintain a broad differential diagnosis in the evaluation and treatment of patients presenting with influenza-like illnesses. OBJECTIVE: This review addresses objective and subjective symptoms commonly associated with influenza and discusses important mimics of influenza viruses, while offering a practical approach to their clinical evaluation and treatment...
February 15, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28212642/beyond-cultural-stereotyping-views-on-end-of-life-decision-making-among-religious-and-secular-persons-in-the-usa-germany-and-israel
#3
Mark Schweda, Silke Schicktanz, Aviad Raz, Anita Silvers
BACKGROUND: End-of-life decision making constitutes a major challenge for bioethical deliberation and political governance in modern democracies: On the one hand, it touches upon fundamental convictions about life, death, and the human condition. On the other, it is deeply rooted in religious traditions and historical experiences and thus shows great socio-cultural diversity. The bioethical discussion of such cultural issues oscillates between liberal individualism and cultural stereotyping...
February 17, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28210388/topical-treatment-for-onychomycosis-is-it-more-effective-than-the-clinical-data-suggests
#4
REVIEW
Boni E Elewski, Tracey C Vlahovic, Andrew Korotzer
Background: The current definition of complete cure is considered too stringent to reflect the true benefit of onychomycosis treatment seen in general practice and may limit the use of newer topical agents in mild-to-moderate disease. In addition, outcomes reported in clinical trials do not consistently report secondary endpoints, making data comparison difficult. Methods: The authors review the clinical data reported on two new topical antifungals, efinaconazole and tavaborole, in light of the latest thinking of more practical approaches to assess improvement and treatment success...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28210286/bilastine-in-allergic-rhinoconjunctivitis-and-urticaria-a-practical-approach-to-treatment-decisions-based-on-queries-received-by-the-medical-information-department
#5
REVIEW
Amalia Leceta, Ander Sologuren, Román Valiente, Cristina Campo, Luis Labeaga
BACKGROUND: Bilastine is a safe and effective commonly prescribed non-sedating H1-antihistamine approved for symptomatic treatment in patients with allergic disorders such as rhinoconjunctivitis and urticaria. It was evaluated in many patients throughout the clinical development required for its approval, but clinical trials generally exclude many patients who will benefit in everyday clinical practice (especially those with coexisting diseases and/or being treated with concomitant drugs)...
2017: Drugs in Context
https://www.readbyqxmd.com/read/28199136/updates-on-mri-evaluation-of-pediatric-large-airways
#6
Mark C Liszewski, Pierluigi Ciet, Kushaljit Singh Sodhi, Edward Y Lee
OBJECTIVE: The purposes of this article are to present a practical approach to imaging of common congenital and acquired diseases of the pediatric large airways with MRI and to describe the imaging findings. CONCLUSION: High-quality MRI of the airways is an increasingly feasible alternative to conventional radiography, fluoroscopy, and CT in the evaluation of many diseases of the pediatric large airways.
February 15, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28198554/practical-approaches-to-adverse-outcome-pathway-aop-development-and-weight-of-evidence-evaluation-as-illustrated-by-ecotoxicological-case-studies
#7
REVIEW
Kellie A Fay, Daniel L Villeneuve, Carlie A LaLone, You Song, Knut Erik Tollefsen, Gerald T Ankley
Adverse Outcome Pathways (AOPs) describe toxicant effects as a sequential chain of causally linked events beginning with a molecular perturbation and culminating in an adverse outcome at an individual or population level. Strategies for developing AOPs are still evolving and depend largely on the intended use or motivation for development and data availability. Four ecotoxicological AOP case studies, developed for different purposes, are described herein. In each situation, creation of the AOP began in a manner determined by the initial motivation for its creation, and expanded either to include additional components of the pathway, or to address the domains of applicability in terms of chemical initiators, susceptible species, life stages, etc...
February 15, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28197883/central-airway-pathology-clinic-features-ct-findings-with-pathologic-and-virtual-endoscopy-correlation
#8
REVIEW
Daniel Barnes, José Gutiérrez Chacoff, Mariana Benegas, Rosario J Perea, Teresa M de Caralt, José Ramirez, Ivan Vollmer, Marcelo Sanchez
OBJECTIVES: To describe the imaging features of the central airway pathology, correlating the findings with those in pathology and virtual endoscopy. To propose a schematic and practical approach to reach diagnoses, placing strong emphasis on multidetector computed tomography (MDCT) findings. METHODS: We reviewed our thoracic pathology database and the central airway pathology-related literature. Best cases were selected to illustrate the main features of each disease...
February 15, 2017: Insights Into Imaging
https://www.readbyqxmd.com/read/28195385/practical-approaches-to-commencing-device-assisted-therapies-for-parkinson-s-disease-in-australia
#9
REVIEW
D R Williams, A H Evans, V S C Fung, M Hayes, R Iansek, T Kimber, J D O'Sullivan, C M Sue
BACKGROUND: In Australia 1% of individuals aged over 50 years have Parkinson's disease (PD). AIMS: Guidance for commencing device-assisted therapies (DATs) for PD in Australia was developed based on a review of European recommendations and their relevance to the local clinical setting. METHODS: An online survey and teleconference discussions were held by a group of eight local movement disorder experts to develop consensus. RESULTS: Referral to a movement disorder specialist and consideration of DAT is appropriate when motor fluctuations cause disability or reduced quality of life, response to treatment is inconsistent or motor fluctuations and dyskinesias require frequent treatment adjustment without apparent benefit and levodopa is required four or more times daily...
February 14, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28191505/correlates-of-health-communication-preferences-in-a-multiethnic-population-of-pregnant-women-and-mothers-of-young-children
#10
Katrina Daoud, Audra Gollenberg, Kim Fendley
BACKGROUND: As posited in multiple health communication theories, it is vital to understand modern health communication preferences among communities in order to develop tailored interventions to reduce Infant Mortality (IM). Literature suggests that health communication inequalities play an important role in infant health knowledge gaps, thus contributing to the disparate IM rates. We sought to understand preferred methods of communication among expectant or mothers of young children of varying sociodemographics...
March 2016: J Health Educ Res Dev
https://www.readbyqxmd.com/read/28186031/the-use-of-case-studies-in-systems-implementations-within-health-care-settings-a-scoping-review
#11
Rav Gill, Elizabeth M Borycki
There is little evidence available in the research literature as to how to undertake an implementation process that ensures electronic medical record (EMR)/electronic health record (EHR) implementation success (i.e. high levels of clinician adoption). The research literature has documented the presence of a direct relationship between how systems are implemented and their level of adoption by clinicians after implementation. In order to develop recommendations for systems implementation to enhance the level of clinician adoption and to ensure EHR/EMR success, researchers need to analyze implementation failures (i...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28178435/an-up-to-date-approach-to-a-patient-with-a-suspected-autoinflammatory-disease
#12
REVIEW
Merav Lidar, Eitan Giat
Autoinflammatory diseases (AID) are characterized by seemingly unprovoked self-limited attacks of fever and systemic inflammation potentially leading to amyloidosis. Familial Mediterranean fever (FMF) is the most common AID and therefore the most studied. Besides FMF, the other main hereditary AID are tumor necrosis factor-associated periodic fever syndrome (TRAPS), mevalonate kinase deficiency (MKD), and cryopyrin-associated periodic fever syndrome (CAPS). These hereditary diseases result from a mutant gene that is involved in the regulation of inflammation, resulting in a characteristic clinical phenotype...
January 30, 2017: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/28176591/promoting-healthy-lifestyle-behaviours-and-well-being-among-nursing-students
#13
Patsy McSharry, Fiona Timmins
First-year university students often embark on university life with excitement. In addition to experiencing greater freedom, they begin to take responsibility for their lives. However, it can be challenging for students to balance their studies with their new self-care responsibilities, while forming peer relationships. Some students may eat a suboptimal diet, for example they may regularly consume 'fast food' rather than healthier alternatives. Their physical activity may also decrease, as a result of time constraints and/or lifestyle choices...
February 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28167515/practical-approaches-to-optimize-adolescent-immunization
#14
Henry H Bernstein, Joseph A Bocchini
With the expansion of the adolescent immunization schedule during the past decade, immunization rates notably vary by vaccine and by state. Addressing barriers to improving adolescent vaccination rates is a priority. Every visit can be viewed as an opportunity to update and complete an adolescent's immunizations. It is essential to continue to focus and refine the appropriate techniques in approaching the adolescent patient and parent in the office setting. Health care providers must continuously strive to educate their patients and develop skills that can help parents and adolescents overcome vaccine hesitancy...
February 6, 2017: Pediatrics
https://www.readbyqxmd.com/read/28165795/book-reviews-problem-solving-in-older-cancer-patients-alistair-ring-danielle-harari-tania-kalsi-janine-mansi-peter-selby-clinical-publishing-2015-price-%C3%A2-39-95-pp-328-isbn-978-1-84692-110-0-universal-healthcare-without-the-nhs-towards-a-patient-centred-health
#15
https://www.readbyqxmd.com/read/28160185/diabetes-distress-or-major-depressive-disorder-a-practical-approach-to-diagnosing-and-treating-psychological-comorbidities-of-diabetes
#16
Kathryn Evans Kreider
The presence of major depressive disorder (MDD) in people with diabetes may be up to three times more common than in the general population. People with diabetes and major depressive disorder have worse health outcomes and higher mortality rates. Diabetes distress refers to an emotional state where people experience feelings such as stress, guilt, or denial that arise from living with diabetes and the burden of self-management. Diabetes distress has also been linked to worse health outcomes. There are multiple treatment options for MDD including pharmacotherapy and cognitive behavioral approaches...
February 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28153805/the-value-of-prognostic-screening-for-patients-with-low-back-pain-in-secondary-care
#17
Emma L Karran, Adrian C Traeger, James H McAuley, Susan L Hillier, Yun-Hom Yau, G Lorimer Moseley
: Prognostic screening in patients with low back pain (LBP) offers a practical approach to guiding clinical decisions. Whether screening is helpful in secondary care is unclear. This prospective cohort study in adults with LBP placed on outpatient clinic waiting lists, compared the performance of the short-form Orebro Musculoskeletal Pain Screening Questionnaire (OMPSQ), the PICKUP Tool (PICKUP) and the STarT Back Tool (SBT). We assessed predictive validity for outcome at 4-month follow-up, by calculating estimates of discrimination, calibration and overall performance...
January 30, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28153305/synthesis-of-pb-nanowires-au-nanoparticles-nanostructure-decorated-with-reduced-graphene-oxide-for-electrochemical-sensing
#18
Wenhao Dong, Yipeng Ren, Yanyan Zhang, Yuan Chen, Cong Zhang, Zhixue Bai, Rui Ma, Qiang Chen
Graphene sheets are a sp(2)-hybridized carbon material that offer extraordinary electrical conductivity and excellent thermal and mechanical properties. They are expected to find use in a wide variety of applications. In this study, a new novel electrocatalyst, a Pb nanowires-Au nanoparticles nanocomposite decorated with reduced graphene oxide (rGO-Pb NWs-Au NPs), was successfully synthesized by an effective and simple approach. Transmission electron microscopy (TEM), X-ray diffraction (XRD) and Raman spectroscopy were employed to observe the as-prepared nanomaterial...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28147552/a-practical-approach-to-the-sensitivity-analysis-for-kinetic-monte-carlo-simulation-of-heterogeneous-catalysis
#19
Max J Hoffmann, Felix Engelmann, Sebastian Matera
Lattice kinetic Monte Carlo simulations have become a vital tool for predictive quality atomistic understanding of complex surface chemical reaction kinetics over a wide range of reaction conditions. In order to expand their practical value in terms of giving guidelines for the atomic level design of catalytic systems, it is very desirable to readily evaluate a sensitivity analysis for a given model. The result of such a sensitivity analysis quantitatively expresses the dependency of the turnover frequency, being the main output variable, on the rate constants entering the model...
January 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28138132/breathing-space-a-practical-approach-to-the-breathless-patient
#20
REVIEW
Nicholas S Hopkinson, Noel Baxter
Breathlessness is a common symptom that may have multiple causes in any one individual and causes that may change over time. Breathlessness campaigns encourage people to see their General Practitioner if they are unduly breathless. Members of the London Respiratory Network collaborated to develop a tool that would encourage a holistic approach to breathlessness, which was applicable both at the time of diagnosis and during ongoing management. This has led to the development of the aide memoire "Breathing SPACE", which encompasses five key themes-smoking, pulmonary disease, anxiety/psychosocial factors, cardiac disease, and exercise/fitness...
December 2017: NPJ Primary Care Respiratory Medicine
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