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CUCI and cancer

Edoardo Fabini, Giovana Maria Lanchoti Fiori, Daniele Tedesco, Norberto Peporine Lopes, Carlo Bertucci
Cucurbitacins are a group of tetracyclic triterpenoids, known for centuries for their anti-cancer and anti-inflammatory properties, which are being actively investigated over the past decades in order to elucidate their mechanism of action. In perspective of being used as therapeutic molecules, a pharmacokinetic characterization is crucial to assess the affinity toward blood carrier proteins and extrapolate distribution volumes. Usually, pharmacokinetic data are first collected on animal models and later translated to humans; therefore, an early characterization of the interaction with carrier proteins from different species is highly desirable...
April 15, 2016: Journal of Pharmaceutical and Biomedical Analysis
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