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https://www.readbyqxmd.com/read/28930649/ph-multistage-responsive-micellar-system-with-charge-switch-and-peg-layer-detachment-for-co-delivery-of-paclitaxel-and-curcumin-to-synergistically-eliminate-breast-cancer-stem-cells
#1
Zhe Yang, Na Sun, Rui Cheng, Chenyang Zhao, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian
Several studies have demonstrated that cancer stem cells (CSCs) are responsible for replenishing bulk tumor cells, generating new tumors and causing metastasis and relapse. Although combination therapy with multiple chemotherapeutics is considered to be a promising approach for simultaneously eliminating non-CSCs and CSCs, it is difficult to deliver drugs into the inner region of a solid tumor where the CSCs are located due to a lack of capillaries. Here, we synthesized a pH-sensitive polymer, poly(ethylene glycol)-benzoic imine-poly(γ-benzyl-l-aspartate)-b-poly(1-vinylimidazole) block copolymer (PPBV), to develop a pH multistage responsive micellar system for co-delivering paclitaxel and curcumin and synergistically eliminating breast cancer stem cells (bCSCs) and non-bCSCs...
September 10, 2017: Biomaterials
https://www.readbyqxmd.com/read/28929255/carbonic-anhydrase-ix-inhibition-affects-viability-of-cancer-cells-adapted-to-extracellular-acidosis
#2
Elena Andreucci, Silvia Peppicelli, Fabrizio Carta, Giulia Brisotto, Eva Biscontin, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Claudiu T Supuran, Lido Calorini
Among the players of the adaptive response of cancer cells able to promote a resistant and aggressive phenotype, carbonic anhydrase IX (CAIX) recently has emerged as one of the most relevant drug targets. Indeed, CAIX targeting has received a lot of interest, and selective inhibitors are currently under clinical trials. Hypoxia has been identified as the master inductor of CAIX, but, to date, very few is known about the influence that another important characteristic of tumor microenvironment, i.e., extracellular acidosis, exerts on CAIX expression and activity...
September 19, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28927587/ph-responsive-carboxymethyl-chitosan-derived-micelles-as-apatinib-carriers-for-effective-anti-angiogenesis-activity-preparation-and-in-vitro-evaluation
#3
Yixing Dai, Shuo Wang, Weibin Shi, Meidong Lang
In this study, carboxymethyl chitosan-graft-poly-(ε-caprolactone) copolymers (CMCS-g-PCL) were synthesized and used to encapsulate apatinib to prepare apatinib-loaded CMCS-g-PCL (CPA) micelles. CPA micelles' sizes were 100-150nm at pH 7.4 while aggregated to 300-350nm at pH 6.4, and the release rate at pH 6.4 was faster than pH 7.4, indicating CPA micelles have a pH-responsive activity. Furthermore, the release rate decreased with an increased grafting ratio of CMCS-g-PCL, which was shown by the results of release experiments from CPA-2 to CPA-10 micelles...
November 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28926265/tobacco-mosaic-virus-delivered-cisplatin-restores-efficacy-in-platinum-resistant-ovarian-cancer-cells
#4
Christina E Franke, Anna E Czapar, Ravi B Patel, Nicole F Steinmetz
Platinum resistance in ovarian cancer is the major determinant of disease prognosis. Resistance can first appear at the onset of disease or develop in response to platinum-based chemotherapy. Due to poor response to alternate chemotherapies and lack of targeted therapies, there is an urgent clinical need for a new avenue toward treatment of platinum-resistant (PR) ovarian cancer. Nanoscale delivery systems hold potential to overcome resistance mechanisms. In this work, we present tobacco mosaic virus (TMV) as a nanocarrier for cisplatin for treatment of PR ovarian cancer cells...
September 19, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28923735/pegylated-magnetic-prussian-blue-nanoparticles-asa-multifunctional-therapeutic-agent-for-combined-targeted-photothermal-ablation-and-ph-triggered-chemotherapy-of-tumour-cells
#5
Peng Xue, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Chang Ming Li, Yuejun Kang
Multifunctional nanoagents have become popular and valuable pharmaceuticals for effective cancer treatment. Moreover, there is an increasing tendency to develop therapeutic agents with excellent biocompatibility, high efficiency, specific targeting and combinatorial treatment effects. In this study, we proposed a facile technique to synthesize PEGylated (polyethylene glycol modified) magnetic Prussian blue (PB) nanoparticles with encapsulated doxorubicin (DOX), abbreviated as Fe3O4@PB/PEG/DOX NPs, for combined targeted photothermal ablation and pH-triggered chemotherapy of tumour cells...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28920426/methotrexate-camptothecin-prodrug-nanoassemblies-as-a-versatile-nanoplatform-for-biomodal-imaging-guided-self-active-targeted-and-synergistic-chemotherapy
#6
Yang Li, Jinyan Lin, Jinyuan Ma, Liang Song, Huirong Lin, Bowen Tang, Dengyue Chen, Guanghao Su, Shefang Ye, Xuan Zhu, Fang-Hong Luo, Zhenqing Hou
"All-in-one" carrier-free-based nano-multi-drug self-delivery system could combine triple advantages of small molecules, nanoscale characteristics, and synergistic combination therapy together. Researches have showed that dual-acting small molecular methotrexate (MTX) could target and kill the folate receptors-overexpressing cancer cells. Inspired by this mechanism, a novel collaborative "early-phase tumor-selective targeting and late-phase synergistic anticancer" approach was developed for the self-assembly of chemotherapeutic drug-drug conjugate, which showed various advantages of more simplicity, efficiency, and flexibility over the conventional approach that was only based on single or combination cancer chemotherapy...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28918670/ph-sensitive-metal-phenolic-network-capsules-for-targeted-photodynamic-therapy-against-cancer-cells
#7
Yuanqing Wei, Zhenzhen Wei, Peicheng Luo, Wei Wei, Songqin Liu
Photodynamic therapy (PDT) is an effective and promising method for cancer treatment, which is proposed for more than one century. However, the specific delivery of photosensitizer to target carcinoma cells to reduce the side effect is still a great challenge. This work provides a strategy to deliver photosensitizers to cancer cells by utilizing pH-sensitive polyethylene glycol metal-phenolic network (PEG-MPN) capsules to encapsulate haematoporphyrin monomethyl ether (HMME). With the assistance of folic acid (FA), HMME-doped PEG-MPN capsules (MPN@HMMEs) accumulate in carcinoma cells selectively followed by releasing HMME in the lysosomes because of the physiologically relevant acidic pH environment...
September 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28917152/pegylated-thermosensitive-lipid-coated-hollow-gold-nanoshells-for-effective-combinational-chemo-photothermal-therapy-of-pancreatic-cancer
#8
Bijay Kumar Poudel, Biki Gupta, Thiruganesh Ramasamy, Raj Kumar Thapa, Shiva Pathak, Kyung Taek Oh, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
Pancreatic cancer has extremely poor prognosis with an 85% mortality rate that results from aggressive and asymptomatic growth, high metastatic potential, and rapid development of resistance to already ineffective chemotherapy. In this study, plasmonic hollow gold nanoshells (GNS) coated with PEGylated thermosensitive lipids were prepared as an efficient platform to ratiometrically co-deliver two drugs, bortezomib and gemcitabine (GNS-L/GB), for combinational chemotherapy and photothermal therapy of pancreatic cancer...
September 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28914292/ph-and-redox-dual-sensitive-polysaccharide-nanoparticles-for-the-efficient-delivery-of-doxorubicin
#9
Shengcai Yang, Zhaohui Tang, Dawei Zhang, Mingxiao Deng, Xuesi Chen
A pH and redox dual-sensitive biodegradable polysaccharide, succinic acid-decorated dextran-g-phenylalanine ethyl ester-g-cysteine ethyl ester (Dex-SA-l-Phe-l-Cys), was synthesized to load doxorubicin hydrochloride (DOX·HCl). The DOX-loaded nanoparticles, which were prepared in aqueous solution and free of organic solvent, could spontaneously self-assemble into uniform sizes. When loading DOX·HCl, mercapto Dex-SA-l-Phe-l-Cys was oxidized into a crosslinked disulfide linkage to form pH and redox dual-sensitive nanoparticles (DOX-S-NPs)...
September 15, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28912886/the-ph-triggered-triblock-nanocarrier-enabled-highly-efficient-sirna-delivery-for-cancer-therapy
#10
Lili Du, Junhui Zhou, Lingwei Meng, Xiaoxia Wang, Changrong Wang, Yuanyu Huang, Shuquan Zheng, Liandong Deng, Huiqing Cao, Zicai Liang, Anjie Dong, Qiang Cheng
Small interfering RNA (siRNA) therapies have been hampered by lack of delivery systems in the past decades. Nowadays, a few promising vehicles for siRNA delivery have been developed and it is gradually revealed that enhancing siRNA release from endosomes into cytosol is a very important factor for successful delivery. Here, we designed a novel pH-sensitive nanomicelle, PEG-PTTMA-P(GMA-S-DMA) (PTMS), for siRNA delivery. Owing to rapid hydrolysis in acidic environment, PTMS NPs underwent hydrophobic-to-hydrophilic transition in endosomes that enabled combination of proton sponge effect and raised osmotic pressure in endosomes, resulting in vigorous release of siRNAs from endosomes into cytosol...
2017: Theranostics
https://www.readbyqxmd.com/read/28910676/porous-nh2-mil-125-as-an-efficient-nano-platform-for-drug-delivery-imaging-and-ros-therapy-utilized-low-intensity-visible-light-exposure-system
#11
Arunkumar Rengaraj, Pillaiyar Puthiaraj, Nam-Su Heo, Hoomin Lee, Seung Kyu Hwang, Soonjo Kwon, Wha-Seung Ahn, Yun-Suk Huh
Metal-organic frameworks are a novel class of organic-inorganic hybrid polymer with potential applications in bioimaging, drug delivery, and ROS therapy. NH2-MIL-125, which is a titanium-based metal organic framework with a large surface area of 1540m(2)/g, was synthesized using a hydrothermal method. The material was characterized by powder X-ray diffreaction (PXRD), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM), and N2 isotherm analyses. The size of the polymer was reduced to the nanoscale using a high-frequency sonication process...
September 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28900512/aptavalve-gated-mesoporous-carbon-nanospheres-image-cellular-mucin-and-provide-on-demand-targeted-drug-delivery
#12
Chengyi Li, Min Qian, Shanshan Wang, Huilin Jiang, Yilin Du, Jianxin Wang, Weiyue Lu, Niren Murthy, Rongqin Huang
In this report, we present a mesoporous carbon nanosphere that can target drugs to tumors and image tumor biomarkers. A single-strand DNA (P0 aptamer) aptavalve was capped on the surface of doxorubicin-loaded oxide mesoporous carbon nanospheres (Dox-OMCN-P0) through π-π stacking for real-time imaging-guided on-demand targeting drug delivery. The Dox-OMCN-P0 could not only realize the detection of MUC1 tumor marker with a wide linear range (0.1 - 10.6 μmol/L) and a low detection limit (17.5 nmol) based on different apparatuses, but also achieve in-situ targeting imaging of cellular MUC1 concentration in vitro and in vivo via "off-on" fluorescence biosensing...
2017: Theranostics
https://www.readbyqxmd.com/read/28898464/functionalized-ultrasmall-fluorinated-graphene-with-high-nir-absorbance-for-controlled-delivery-of-mixed-anticancer-drugs
#13
Peiwei Gong, Qiao Zhao, Dujuan Dai, Shumiao Zhang, Zhenzhen Tian, Lu Sun, Jiashuo Ren, Zhe Liu
Fluorinated graphene (FG) possess distinctively novel properties different from graphene and is suitable for many biomedical applications. However, the hydrophobic nature and inert property of FG are limiting its further application as biological materials. Here we show the preparation of nanosized FG (60 nm) that exhibits high NIR absorbance for photothermal therapy. In order to make it stable in physiological solutions, FG is enriched with oxygen and followed by covalent binding with chitosan as a novel pH-responsive nanocarrier...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28894364/epcam-aptamer-functionalized-polydopamine-coated-mesoporous-silica-nanoparticles-loaded-with-dm1-for-targeted-therapy-in-colorectal-cancer
#14
Yang Li, Yanhong Duo, Shiyun Bao, Lisheng He, Kai Ling, Jinfeng Luo, Yue Zhang, Hao Huang, Han Zhang, Xiaofang Yu
DM1, a maytansine derivative, is a highly potential cytotoxic agent but with severe side effects; therefore, its application in clinical cancer therapy is limited. Here, in order to mitigate this intrinsic drawback of DM1, we developed mesoporous silica nanoparticles (MSNs) loaded with DM1 and surface-decorated with hydrochloride dopamine (PDA), polyethylene glycol (PEG), and epithelial cell adhesion molecule (EpCAM) aptamer (APt) for the targeted treatment of colorectal cancer (CRC). In this system, the PDA coating could be used as pH-sensitive gatekeepers to control the release of DM1 from MSNs in response to the pH stimulus and EpCAM APt-guided active targeting enables the increased delivery of DM1 to CRC as well as a reduction in toxicity and side effects by minimizing the exposure of normal tissues to DM1...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28890258/facile-construction-of-bioreducible-crosslinked-polypeptide-micelles-for-enhanced-cancer-combination-therapy
#15
Hima Bindu Ruttala, Natarajan Chitrapriya, Kaliappan Kaliraj, Thiruganesh Ramasamy, Woo Hyun Shin, Jee-Heon Jeong, Jae Ryong Kim, Sae Kwang Ku, Han-Gon Choi, Chul Soon Yong, Jong Oh Kim
In this study, we developed pH and redox-responsive crosslinked polypeptide-based combination micelles for enhanced chemotherapeutic efficacy and minimized side effects. The stability and drug release properties of the polypeptide micelles were efficiency balanced by the corona-crosslinking of the triblock copolymer, poly(ethylene glycol)-b-poly(aspartic acid)-b-poly(tyrosine) (PEG-b-pAsp-b-pTyr) with coordinated redox and pH dual-sensitivity by introducing disulfide crosslinkages. Because of the crosslinking of the middle shell of the triblock polypeptide micelles, their robust structure was maintained in strong destabilization conditions and exhibited excellent stability...
September 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28890213/oxygen-generating-nanoparticles-for-improved-photodynamic-therapy-of-hypoxic-tumours
#16
Yingjie Sheng, Heather Nesbitt, Bridgeen Callan, Mark A Taylor, Mark Love, Anthony P McHale, John F Callan
Photodynamic therapy (PDT) is a clinically approved anti-cancer treatment that involves the activation of an otherwise inactive sensitiser drug with light, which in the presence of molecular oxygen, generates cytotoxic reactive oxygen species (ROS). As oxygen is a key requirement for the generation of ROS in PDT and given the fact that hypoxia is a characteristic of most solid cancerous tumours, treating hypoxic tumours using PDT can be a challenge. In this manuscript, we have prepared a CaO2 nanoparticle (NP) formulation coated with a pH-sensitive polymer to enable the controlled generation of molecular oxygen as a function of pH...
September 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28888000/ph-and-redox-dual-stimulate-responsive-nanocarriers-based-on-hyaluronic-acid-coated-mesoporous-silica-for-targeted-drug-delivery
#17
Jian-Tao Lin, Ji-Kun Du, Yi-Qiu Yang, Li Li, Da-Wei Zhang, Cui-Ling Liang, Jie Wang, Jun Mei, Guan-Hai Wang
In this work, we developed a drug-conjugated nanocarrier with "zero premature release" property for actively targeted drug delivery. The pH and redox dual-responsive nanocarrier was fabricated based on hyaluronic acid (HA) modified the mesoporous silica nanoparticles (MSNs). Doxorubicin (DOX) was conjugated to MSNs via hydrazone bonds, which can be cleaved in tumor tissue (acidic conditions). To improve specific cellular uptake and stability of nanocarriers, HA was equipped with an outer shell on the nanoparticle surface via a disulfide crosslinker...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887972/dual-targeting-hyaluronic-acid-rgd-mesoporous-silica-coated-gold-nanorods-for-chemo-photothermal-cancer-therapy
#18
Huimin Zhou, Haixing Xu, Xin Li, Yahui Lv, Tian Ma, Shiying Guo, Zhijun Huang, Xiaobing Wang, Peihu Xu
This work reports a multifunctional nanoplatform (GNRs@mSiO2-HA-RGD) by conjugating targeting ligand hyaluronic acid (HA) and RGD with mesoporous silica-coated gold nanorods (GNRs@mSiO2) for dual-targeted chemo-photothermal therapy. Doxorubicin hydrochloride (DOX) was used as the model drug to investigate the drug loading, in vitro drug release profiles and cell evaluation. The nanoplatform has demonstrated a good photothermal effect and excellent drug loading capacity of about 20.16%. It also had pH-enzyme sensitive and NIR-triggered drug release properties...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28886514/fabrication-of-polymer-matrix-free-nanocomposites-based-on-angelica-gigas-nakai-extract-and-their-application-to-breast-cancer-therapy
#19
Song Yi Lee, Jeong-Jun Lee, Suyeong Nam, Wie-Soo Kang, In-Soo Yoon, Hyun-Jong Cho
Nanocomposites (NCs) based on the ethanol extract of Angelica gigas Nakai (AGN EtOH ext) were developed for breast cancer therapy. Polymer matrix-free nano-sized particles based on the extract of natural product were fabricated using a modified emulsification-solvent evaporation method. Without the use of polymer matrix, toxicity can be minimized and the clinical application may be assured. AGN NCs with approximately 200nm mean diameter, narrow size distribution, and negative zeta potential were prepared in this study...
August 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28885731/a-multifunctional-nanocarrier-for-efficient-trail-based-gene-therapy-against-hepatocellular-carcinoma-with-desmoplasia
#20
Chun-Hung Liu, Guann-Gen Chern, Fu-Fei Hsu, Kuan-Wei Huang, Yun-Chieh Sung, Hsi-Chien Huang, Jiantai Timothy Qiu, Sheng-Kai Wang, Chu-Chi Lin, Chien-Hsun Wu, Han-Chung Wu, Jia-Yu Liu, Yunching Chen
The anti-cancer efficacy of TNF-related apoptosis-inducing ligand (TRAIL)-based therapy is limited due to systemic toxicity, poor bioavailability, and the development of TRAIL-resistance. We developed a tumor-targeted LCPP (Lipid/Calcium/Phosphate/Protamine) nanoparticle (NP) to deliver TRAIL plasmid DNA (pDNA) into hepatocellular carcinoma (HCC) cells. TRAIL pDNA was encapsulated in a pH stimuli-responsive calcium phosphate (CaP) core, and protamine was added to facilitate nuclear delivery of pDNA. In addition, the intracellular release of Ca(2+) from the CaP core overcame TRAIL resistance via calcium influx-dependent DR5 upregulation...
September 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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