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https://www.readbyqxmd.com/read/29334189/a-multifunctional-micellar-nanoplatform-with-ph-triggered-cell-penetration-and-nuclear-targeting-for-effective-cancer-therapy-and-inhibition-to-lung-metastasis
#1
Yuting Jing, Xiang Xiong, Yang Ming, Jingya Zhao, Xing Guo, Guang Yang, Shaobing Zhou
The enhancement of cellular internalization and subsequent achievement of a nuclear targeting of nanocarriers play an important role in maximizing the therapeutic potency and minimizing the side effects of encapsulated drugs. Herein, a multifunctional micellar nanoplatform simultaneously with high cell penetration and nuclear targeting through pH-triggered surface charge reversal is presented. The miscellar system is constructed from poly(ethylene glycol)-poly(ε-caprolactone) with 2,3-dimethylmaleic anhydride-Tat decoration (PECL/DA-Tat)...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29334184/ph-responsive-peg-doxorubicin-encapsulated-aza-bodipy-nanotheranostic-agent-for-imaging-guided-synergistic-cancer-therapy
#2
Dapeng Chen, Qianyun Tang, Jianhua Zou, Xiaoyan Yang, Wei Huang, Qi Zhang, Jinjun Shao, Xiaochen Dong
Synergistic cancer therapy is of great interest for multiple advantages, such as excellent targeting accuracy, low side effects, and enhanced therapeutic efficiency. Herein, a near-infrared photosensitizer aza-BODIPY (AB) with high singlet oxygen quantum yield (ΦΔ = 82%) is designed and synthesized. With Schiff's base obtained from condensation reaction between doxorubicin (DOX) and polyethylene glycol-benzaldehyde (PEG-CHO) as the polymer matrix, aza-BODIPY is encapsulated to afford hydrophilic nanoparticles (DAB NPs)...
January 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29332566/stimuli-responsive-nanoparticles-for-controlled-anti-cancer-drug-release
#3
Qi Tang, Bing Yu, Lilong Gao, Hailin Cong, Na Song, Chenghao Lu
Conventional drugs used for cancer chemotherapy have severe toxic side effects and show individually varied therapeutic responses. The convergence of nanotechnology, biology, material science and pharmacy offers a perspective strategy for cancer chemotherapy. Nanoparticles loaded with anti-cancer drug have been designed to overcome the limitations associated with conventional drugs, several nanomedicines have been approved by FDA and shown good performances in clinical practice. However, the therapeutic efficacies cannot be enhanced...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29328488/synthesis-and-application-of-131i-fulvestrant-as-a-targeted-radiation-drug-for-endocrine-therapy-in-human-breast-cancer
#4
Guobing Yin, Bin Zeng, Zhiping Peng, Ying Liu, Lu Sun, Changan Liu
The aim of this study was to label fulvestrant (an endocrine therapy drug for breast cancer) with radioiodine and to evaluate the effect of 131I-fulvestrant on inhibiting the growth of human breast cancer and its influence on major organs in nude mice. Fulvestrant was labeled with radioiodine using a modified chloramine T method, and its chemical properties were assessed using traditional methods. The binding affinity of 131I-fulvestrant was measured by radioligand binding assays, and its antiproliferative activity was determined by MTT assays...
January 11, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29320951/glutathione-conjugated-polyethylenimine-on-the-surface-of-fe3o4-magnetic-nanoparticles-as-a-theranostic-agent-for-targeted-and-controlled-curcumin-delivery
#5
Navid Aeineh, Fahimeh Salehi, Mohammad Akrami, Firouzeh Nemati, Masoumeh Alipour, Milad Ghorbani, Banafsheh Nikfar, Fatemeh Salehian, Nader Riyahi Alam, Seyed Esmaeil Sadat Ebrahimi, Alireza Foroumadi, Mehdi Khoobi, Mohammadreza Rouini, Maryam Dibaei, Ismaeil Haririan, Mohammad Reza Ganjali, Saeed Safaei
Theranostics with the ability to simultaneous monitoring of treatment progress and controlled delivery of therapeutic agents has become as an emerging therapeutic paradigm in cancer therapy. In this study, we have developed a novel surface functionalized iron oxide nanoparticle using polyethyleneimine (PEI) and glutathione (GSH) for targeted curcumin (CUR) delivery and acceptable pH sensitive character. The developed magnetic nanoparticles (MNPs) were physicochemically characterized by FT-IR, XRD, FE-SEM and TEM...
January 11, 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29318879/intelligent-mos2-nanotheranostic-for-targeted-and-enzyme-ph-nir-responsive-drug-delivery-to-overcome-cancer-chemotherapy-resistance-guided-by-pet-imaging
#6
Xinghua Dong, Wenyan Yin, Xiao Zhang, Shuang Zhu, Xiao He, Jie Yu, Jiani Xie, Zhao Guo, Liang Yan, Xiangfeng Liu, Qing Wang, Zhanjun Gu, Yuliang Zhao
Chemotherapy resistance remains a major hurdle for cancer therapy in clinic due to poor cellular uptake, insufficient intracellular release of drugs. Herein, an intelligent, multifunctional MoS2 nanotheranostic (MoS2-PEI-HA) ingeniously decorating with biodegradable hyaluronic acid (HA) assisted by polyethyleneimine (PEI) is reported to combat drug-resistant breast cancer (MCF-7-ADR) after loading with chemotherapy drug doxorubicin (DOX). The HA can not only target CD44-overexpressing MCF-7-ADR, but also be degraded by hyaluronidase (HAase) that is concentrated in the tumor microenvironment and thus to accelerate doxorubicin (DOX) release...
January 10, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29316453/degradable-rhenium-trioxide-nanocubes-with-high-localized-surface-plasmon-resonance-absorbance-like-gold-for-photothermal-theranostics
#7
Wenlong Zhang, Guoying Deng, Bo Li, Xinxin Zhao, Tao Ji, Guosheng Song, Zhiyin Xiao, Qing Cao, Jingbo Xiao, Xiaojuan Huang, Guoqiang Guan, Rujia Zou, Xinwu Lu, Junqing Hu
The applications of inorganic theranostic agents in clinical trials are generally limited to their innate non-biodegradability and potential long-term biotoxicity. To address this problem, herein via a straightforward and tailored space-confined on-substrate route, we obtained rhenium trioxide (ReO3) nanocubes (NCs) that display a good biocompatibility and biosafety. Importantly, their aqueous dispersion has high localized surface plasmon resonance (LSPR) absorbance in near-infrared (NIR) region different from previous report, which possibly associates with the charge transfer and structural distortion in hydrogen rhenium bronze (HxReO3), as well as ReO3's cubic shape...
December 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/29315855/near-infrared-upconversion-mesoporous-cerium-oxide-hollow-biophotocatalyst-for-concurrent-ph-h2-o2-responsive-o2-evolving-synergetic-cancer-therapy
#8
Chi Yao, Wenxing Wang, Peiyuan Wang, Mengyao Zhao, Xiaomin Li, Fan Zhang
Tumor hypoxia is typically presented in the central region of solid tumors, which is mainly caused by an inadequate blood flow and oxygen supply. In the conventional treatment of hypoxic human tumors, not only the oxygen-dependent photodynamic therapy (PDT), but also antitumor drug-based chemotherapy, is considerably limited. The use of direct oxygen delivering approach with oxygen-dependent PDT or chemotherapy may potentiate the reactive oxygen species (ROS)-mediated cytotoxicity of the drug toward normal tissues...
January 8, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29315139/-dtpa-pabn-leu5-des-acyl-ghrelin-1-5-as-a-new-carrier-of-radionuclides-and-potential-precursor-of-radiopharmaceuticals
#9
Grzegorz Wójciuk, Marcin Kruszewski
BACKGROUND: Ghrelin is a peptide consisting of 28 aminoacids and an octadecyl side chain (acyl group) binding to the growth hormone secretagogue receptor type 1a (GHS-R1a). Its des-acylated form, des-acyl ghrelin (DAG) binds to the corticotropin releasing factor receptor type 2a (CRF2a) located on endocrine cancer cells such as the prostate carcinoma cell line DU 145. AIM: The aim of this study is to develop a new DAG-based carrier of radionuclides with potential application in therapy...
January 8, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29304403/targeting-death-receptors-for-drug-resistant-cancer-therapy-codelivery-of-ptrail-and-monensin-using-dual-targeting-and-stimuli-responsive-self-assembling-nanocomposites
#10
Fan Xu, Huihai Zhong, Ya Chang, Dongdong Li, Hongyue Jin, Meng Zhang, Huiyuan Wang, Chen Jiang, Youqing Shen, Yongzhuo Huang
Chemoresistance remains a formidable hurdle against cancer therapy. Seeking for novel therapy strategies is an urgent need for those who no longer benefit from chemotherapy. Chemoresistance is usually associated with the dysfunction of intrinsic apoptosis. Targeting extrinsic apoptosis via TRAIL signaling and the death receptors could be a potential solution to treat chemoresistant cancer. A highly biocompatible nano system for codelivery of the TRAIL DNA and the death receptor sensitizer monensin was developed, in which low-molecular-weight PEI (LMW-PEI) was crosslinked by the sulfhydryl cyclodextrin via disulfide bonds, and then bound with DNA, thus forming the bioreducible polyplex cores...
December 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/29300453/novel-metal-polyphenol-framework-for-mr-imaging-guided-photothermal-therapy
#11
Gaozheng Zhao, Huihui Wu, Ruilu Feng, Dongdong Wang, Pengping Xu, Peng Jiang, Kang Yang, Zhen Guo, Haibao Wang, Qianwang Chen
Phothermal therapy has received increasing attention in recent years as a potentially effective way for treatment of cancer. In pursuit of a more biocompatible photothermal agent, we utilize bio-safe materials-ellagic acid (EA), polyvinyl pyrrolidone (PVP) and iron element as the building blocks, and successfully fabricate homogeneous nanosized Fe-EA framework for the first time by a facile method. As expected, the novel nano-agent exhibits no obvious cytotoxicity and good hemocompatibility in vitro and in vivo...
January 4, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29296083/enhanced-antitumor-efficacy-of-doxorubicin-encapsulated-halloysite-nanotubes
#12
Kai Li, Yongxing Zhang, Mengting Chen, Yangyang Hu, Weiliang Jiang, Li Zhou, Sisi Li, Min Xu, Qinghua Zhao, Rong Wan
To improve the antitumor efficacy of doxorubicin (DOX) and provide novel clinical treatment of gastric cancer, halloysite nanotubes (HNTs) loaded with DOX were encapsulated by soybean phospholipid (LIP) and the formed HNTs/DOX/LIP was systematically characterized via different techniques. The in vitro anticancer activity of HNTs/DOX/LIP was examined using an MTT assay. The antitumor efficacy and biocompatibility were monitored by measuring the tumor volume and assessing the blood routine and serum biochemistry using an ectopic implantation cancer model...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29290753/tantalum-sulfide-nanosheets-as-a-theranostic-nanoplatform-for-computed-tomography-imaging-guided-combinatorial-chemo-photothermal-therapy
#13
Yanlan Liu, Xiaoyuan Ji, Jianhua Liu, Winnie W L Tong, Diana Askhatova, Jinjun Shi
Near-infrared (NIR)-absorbing metal-based nanomaterials have shown tremendous potential for cancer therapy, given their facile and controllable synthesis, efficient photothermal conversion, capability of spatiotemporal-controlled drug delivery, and intrinsic imaging function. Tantalum (Ta) is among the most biocompatible metals and arouses negligible adverse biological responses in either oxidized or reduced forms, and thus Ta-derived nanomaterials represent promising candidates for biomedical applications...
October 19, 2017: Advanced Functional Materials
https://www.readbyqxmd.com/read/29286625/mof-nanoparticles-with-encapsulated-autophagy-inhibitor-in-controlled-drug-delivery-system-for-antitumor
#14
Xuerui Chen, Rongliang Tong, Zheqi Shi, Beng Yang, Hua Liu, Shiping Ding, Xu Wang, Qunfang Lei, Jian Wu, Wenjun Fang
High porosities, large surface areas and tunable functionalities made metalorganic frameworks (MOFs) as effective carriers for drug delivery. One of the most promising MOFs is the zeolitic imidazolate framework (ZIF-8) crystal, an advanced functional material for small-molecule delivery, due to its high loading ability and pH-sensitive degradation. As a novel carrier, ZIF-8 nanoparticles were used in this work to control the release of an autophagy inhibitor, 3-methyladenine (3-MA), and prevent it from dissipating in a large quantity before reaching the target...
December 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29285401/multifunctional-stimuli-responsive-polymer-gated-iron-and-gold-embedded-silica-nano-golf-balls-nanoshuttles-for-targeted-on-demand-theranostics
#15
Liping Wang, Grace Jang, Deependra Kumar Ban, Vrinda Sant, Jay Seth, Sami Kazmi, Nirav Patel, Qingqing Yang, Joon Lee, Woraphong Janetanakit, Shanshan Wang, Brian P Head, Gennadi Glinsky, Ratneshwar Lal
Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload...
2017: Bone Research
https://www.readbyqxmd.com/read/29282879/a-modularly-designable-vesicle-for-sequentially-multiple-loading
#16
Yiyang Zhang, Dandan Bao, Shuo Wang, Yuancheng Dong, Fen Wu, Haitao Li, Dongsheng Liu
The vesicle is one of the most intriguing platforms for drug delivery, which is believed to improve drug efficacy. In the past few decades, a great deal of materials have been explored to make vesicles, including lipids, block copolymers, dendrons, erythrocyte membranes, and even DNA. Other than shape and size control, most efforts are focused on achieving certain functions, for example, an abundance of stimuli-responsive features are introduced to vesicles, which can be applied to controllable release, such as pH, redox, light, radiation, enzyme etc...
December 28, 2017: Small
https://www.readbyqxmd.com/read/29278801/smart-ph-sensitive-micelles-based-on-redox-degradable-polymers-as-dox-gnps-carriers-for-controlled-drug-release-and-ct-imaging
#17
Di Xiong, Xiaofang Zhang, Shiyuan Peng, Huawei Gu, Lijuan Zhang
An amphiphilic copolymer poly(ε-caprolactone)-ss-poly(2-(dimethylamino) ethyl methacrylate), PCL-SS-PDMAEMA, was designed and synthesized using ROP and ARGET ATRP methods. Dual stimulus responsive micelles were prepared by the self-assembly of PCL-SS-PDMAEMA. PDMAEMA could respond to acid conditions with protonation, followed by enhanced hydrophilicity and swelling of the micellar shell. In addition, the cleavable joint disulfide bond between the core and shell was disrupted when exposed to an abundance of the reductant reductive glutathione GSH, leading to the disassembly of the micellar structure...
December 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29275049/the-multiple-slit-technique-must-for-penile-length-and-girth-restoration
#18
Paulo H Egydio, Franklin E Kuehhas
BACKGROUND: Patients with severe erectile dysfunction (ED) and penile size issues, especially seen in Peyronie's disease (PD), are candidates for more invasive penile prosthesis insertion techniques that aim for penile length and girth reconstruction. AIM: To present the feasibility and safety of penile length and girth restoration based on the so-called multiple-slit technique (MUST) for patients with severe ED and significant penile shortening with or without PD...
December 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29261277/aiegen-functionalized-mesoporous-silica-gated-by-cyclodextrin-modified-cus-for-cell-imaging-and-chemo-photothermal-cancer-therapy
#19
Qing-Lan Li, Duo Wang, Yuanzheng Cui, Zhiying Fan, Li Ren, Dongdong Li, Jihong Yu
A novel multifunctional drug delivery system has been constructed by assembling per-6-thio-β-cyclodextrin-modified ultrasmall CuS nanoparticles (CD-CuS) onto fluorescent AIEgen-containing mesoporous silica nanoparticles (FMSN). The CD-CuS nanoparticles are anchored on the surface of benzimidazole-grafted FMSN, acting as a gatekeeper and photothermal agent. The prepared blue-emitting nanocomposite (FMSN@CuS) exhibits good biocompatibility and cell imaging capability. Anticancer drug doxorubicin hydrochloride (DOX) molecules are loaded into FMSN@CuS, and zero prerelease at physiological pH (7...
December 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29250957/nucleolin-targeting-as1411-aptamer-modified-graft-polymeric-micelle-with-dual-ph-redox-sensitivity-designed-to-enhance-tumor-therapy-through-the-codelivery-of-doxorubicin-tlr4-sirna-and-suppression-of-invasion
#20
Shudi Yang, Zhaoxiang Ren, Mengtian Chen, Ying Wang, Bengang You, Weiliang Chen, Chenxi Qu, Yang Liu, Xuenong Zhang
In this article, a novel graft polymeric micelle with targeting function ground on aptamer AS1411 was synthesized. The micelle was based on chitosan-ss-polyethylenimine-urocanic acid (CPU) with dual pH/redox sensitivity and targeting effects. This micelle was produced for codelivering Toll-like receptor 4 siRNA (TLR4-siRNA) and doxorubicin (Dox). In vitro investigation revealed the sustained gene and drug release from Dox-siRNA-loaded micelles under physiological conditions, and this codelivery nanosystem exhibited high dual pH/redox sensitivity, rapid intracellular drug release, and improved cytotoxicity against A549 cells in vitro...
December 18, 2017: Molecular Pharmaceutics
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