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https://www.readbyqxmd.com/read/28081462/in%C3%A2-vitro-evaluation-of-biodegradable-lignin-based-nanoparticles-for-drug-delivery-and-enhanced-antiproliferation-effect-in-cancer-cells
#1
Patrícia Figueiredo, Kalle Lintinen, Alexandros Kiriazis, Ville Hynninen, Zehua Liu, Tomás Bauleth-Ramos, Antti Rahikkala, Alexandra Correia, Tomáš Kohout, Bruno Sarmento, Jari Yli-Kauhaluoma, Jouni Hirvonen, Olli Ikkala, Mauri A Kostiainen, Hélder A Santos
Currently, nanosystems have been developed and applied as promising vehicles for different biomedical applications. We have developed three lignin nanoparticles (LNPs): pure lignin nanoparticles (pLNPs), iron(III)-complexed lignin nanoparticles (Fe-LNPs), and Fe3O4-infused lignin nanoparticles (Fe3O4-LNPs) with round shape, narrow size distribution, reduced polydispersity and good stability at pH 7.4. The LNPs showed low cytotoxicity in all the tested cell lines and hemolytic rates below 12% after 12 h of incubation...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28081185/upregulated-expression-of-transient-receptor-potential-cation-channel-subfamily-v-receptors-in-mucosae-of-patients-with-oral-squamous-cell-carcinoma-and-patients-with-a-history-of-alcohol-consumption-or-smoking
#2
Akiko Sakakibara, Shunsuke Sakakibara, Junya Kusumoto, Daisuke Takeda, Takumi Hasegawa, Masaya Akashi, Tsutomu Minamikawa, Kazunobu Hashikawa, Hiroto Terashi, Takahide Komori
OBJECTIVES: Transient receptor potential cation channel (subfamily V, members 1-4) (TRPV1-4) are expressed in skin and neurons and activated by external stimuli in normal mucosae of all oral cavity sites. The oral cavity is exposed to various stimuli, including temperature, mechanical stimuli, chemical substances, and changes in pH, and, notably, the risk factors for oncogenic transformation in oral squamous epithelium are the same as the external stimuli received by TRPV1-4 receptors...
2017: PloS One
https://www.readbyqxmd.com/read/28073063/self-assembled-micelles-based-on-chondroitin-sulfate-poly-d-l-lactideco-glycolide-block-copolymers-for-doxorubicin-delivery
#3
Hui Zhang, Jiangkang Xu, Liang Xing, Jianbo Ji, Aihua Yu, Guangxi Zhai
Doxorubicin (DOX) is one of the most common chemotherapeutic agents for the treatment of various cancers, but its clinical usage is limited by dose-dependent cardiotoxicity. We have recently synthesized a series of Chondroitin sulfate/poly (d,l-lactideco-glycolide) block copolymers (Chs-b-PLGA) with different length of hydrophobic block by an end-to-end coupling strategy. The structure of the amphiphilic block copolymers with low critical micelle concentration (∼28mg/L) were confirmed by (1)H NMR. The copolymers could self-assemble into stable micelles in aqueous environment with homogeneous size distribution and negative zeta potential...
December 23, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28069501/photothermal-and-biodegradable-polyaniline-porous-silicon-hybrid-nanocomposites-as-drug-carriers-for-combined-chemo-photothermal-therapy-of-cancer
#4
Bing Xia, Bin Wang, Jisen Shi, Yu Zhang, Qi Zhang, Zhenyu Chen, Jiachen Li
: To develop photothermal and biodegradable nanocarriers for combined chemo-photothermal therapy of cancer, polyaniline/porous silicon hybrid nanocomposites had been successfully fabricated via surface initiated polymerization of aniline onto porous silicon nanoparticles in our experiments. As-prepared polyaniline/porous silicon nanocomposites could be well dispersed in aqueous solution without any extra hydrophilic surface coatings, and showed a robust phototherml effect under near-infrared (NIR) laser irradiation...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28069070/successful-management-of-synchronous-recurrent-breast-carcinoma-with-chronic-myelogenous-leukemia-a-case-report
#5
Choukri Elm'hadi, Mohamed Reda Khmamouche, Rachid Tanz, Mehdi Toreis, ElMehdi Mahtat, Mohammed Allaoui, Mohammed Oukabli, Nezha Messaoudi, Hassan Errihani, Mohammed Ichou
BACKGROUND: Survival is increasing after early breast cancer revealing frequent relapses and possibility of developing secondary malignancies. The concomitant occurrence of these two events is exceptionally disastrous and lethal. We report a case of a Moroccan woman who was successfully managed for synchronous recurrent breast carcinoma and chronic myelogenous leukemia. CASE PRESENTATION: A 42-year-old Moroccan woman was diagnosed with localized breast carcinoma in 2008...
January 10, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28068545/design-preparation-and-characterization-of-ph-responsive-prodrug-micelles-with-hydrolyzable-anhydride-linkages-for-controlled-drug-delivery
#6
Girija Seetharaman, Adarsh R Kallar, Vineeth M Vijayan, Jayabalan Muthu, Shivaram Selvam
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via hydrolytic anhydride linkages for potential controlled release applications of NSAIDs. Synthesized mPEG-PPF-Ibu polymer drug conjugates (PDCs) demonstrated high drug conjugation efficiency (∼90%) and self-assembled to form micellar nanostructures in aqueous medium with critical micelle concentrations ranging between 16 and 30μg/mL...
December 31, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28065864/value-of-ph-regulators-in-the-diagnosis-prognosis-and-treatment-of-cancer
#7
REVIEW
Sara Granja, Diana Tavares-Valente, Odília Queirós, Fátima Baltazar
Altered metabolism, associated with acidification of the extracellular milieu, is one of the major features of cancer. As pH regulation is crucial for the maintenance of all biological functions, cancer cells rely on the activity of lactate exporters and proton transporters to regulate their intracellular pH. The major players in cancer pH regulation are proton pump ATPases, sodium-proton exchangers (NHEs), monocarboxylate transporters (MCTs), carbonic anhydrases (CAs) and anion exchangers (AEs), which have been shown to be upregulated in several human malignancies...
January 5, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/28063407/synthesis-and-in-vitro-photodynamic-therapy-of-chlorin-derivative-13-1-ortho-trifluoromethyl-phenylhydrazone-modified-pyropheophorbide-a
#8
Jianjun Cheng, Wenting Li, Guanghui Tan, Zhiqiang Wang, Shuying Li, Yingxue Jin
Photodynamic therapy (PDT) is entering the mainstream of the cancer treatments recently. Pyropheophorbide-a (Pa), as a degradation product of chlorophyll-a, has been shown to be a potent photosensitizer in photodynamic therapy. In this paper, we investigated the in vitro photodynamic therapy of 13(1)-ortho-trifluoromethyl-phenylhydrazone modified pyropheophorbide-a (PHPa) against human HeLa cervical cancer cell line, together with ultraviolet-visible spectra, fluorescence emission spectra, stability in various solvents, and single oxygen quantum yield...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28063272/a-shell-crosslinked-polymeric-micelle-system-for-ph-redox-dual-stimuli-triggered-dox-on-demand-release-and-enhanced-antitumor-activity
#9
Lele Wang, Jing Zhang, Meijia Song, Baocheng Tian, Keke Li, Yan Liang, Jingtian Han, Zimei Wu
Based on targeted amphiphilic block copolymer N-acetyl glucosamine-poly (styrene-alt-maleic anhydride)58-b-polystyrene130 (NAG-P(St-alt-MA)58-b-PSt130), a pH/redox dual-triggered shell-crosslinked polymeric micelle system was constructed. The shell-crosslinked micelles (CLM) were prepared by post-crosslinking method to regulate drug release kinetics using cystamine as linkers between carboxy groups of the shell. Compared with non-crosslinked micelles (NCLM), CLM showed spherical shapes with little increased mean diameter of 102...
December 21, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28055201/tumor-microenvironment-sensitive-liposomes-penetrate-tumor-tissue-via-attenuated-interaction-of-the-extracellular-matrix-and-tumor-cells-and-accompanying-actin-depolymerization
#10
Satoko Suzuki, Shoko Itakura, Ryo Matsui, Kayoko Nakayama, Takayuki Nishi, Akinori Nishimoto, Susumu Hama, Kentaro Kogure
Delivery of anti-cancer drugs into tumor cores comprised of malignant cancer cells can result in potent therapeutic effects. However, conventional nanoparticle-based drug delivery systems used for cancer therapy often exhibit inefficient tumor-penetrating properties, thus suggesting the need to improve the functional design of such systems. Herein, we focus on the interactions between cancer cells and the extracellular matrix (ECM), and demonstrate that liposomes modified with slightly acidic pH-sensitive peptide (SAPSp-lipo) can penetrate in vivo tumor tissue and in vitro spheroids comprised of cancer cells and ECM...
January 5, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28046887/we-fg-bra-02-docetaxel-eluting-brachytherapy-spacers-for-local-chemo-radiation-therapy-in-prostate-cancer
#11
J Belz, R Kumar, G Makrigiorgos, A D'Amico, P Nguyen, R Cormack, S Sridhar
PURPOSE: We propose an innovative combinatorial treatment strategy of Local ChemoRadiation Therapy (LCRT) using a sustained drug delivery platform in the form of a spacer to locally radio-sensitize the prostate with Docetaxel (DTX) enabling a synergistic cure with the use of lower radiation doses. These biodegradable spacers are physically similar to the inert spacers routinely used in prostate brachytherapy but are now loaded with formulations of DTX. METHODS: Spacers were loaded with ∼500µg Docetaxel (DTX) for prostate cancer studies...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046538/tu-h-campus-tep2-05-selective-protection-of-normal-tissue-by-cerium-oxide-nanoparticles-during-radiation-therapy
#12
Z Ouyang, S Yasmin-Karim, G Strack, E Sajo, W Ngwa
PURPOSE: Cerium oxide nanoparticles (CONPs) have unique pH dependent properties such that they act as a radical modulator. These properties may be used in radiation therapy (RT) to protect normal tissue. This work investigates the selective radioprotection of CONPs in-vitro and potential for in-situ delivery of CONPs in prostate cancer RT. METHODS: i) Normal human umbilical vein endothelial cells (HUVEC) and human prostate cancer cells (PC-3) were treated with 0 or 2 ng/mL CONPs (NP size: 5 nm)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044342/in-vitro-cytotoxicity-and-combination-effects-of-the-docetaxel-conjugated-and-doxorubicin-conjugated-poly-lactic-acid-poly-ethylene-glycol-folate-based-polymeric-micelles-in-human-ovarian-cancer-cells
#13
Zahra Hami, Seyed Mahdi Rezayat, Kambiz Gilani, Mohsen Amini, Mahmoud Ghazi-Khansari
OBJECTIVES: The pH-sensitive doxorubicin (DOX)-conjugated and docetaxel (DTX)-conjugated poly(lactic acid)-poly(ethylene glycol)-folate (PLA-PEG-FOL)-based polymeric micelles were developed and characterized in this study. KEY FINDINGS: The drugs were released from the micelles (particle size, ~185 nm) in a pH-dependent manner. The drug-conjugated PLA-PEG-FOL micelles showed higher cellular uptake than nontargeting ones. Single agent and combination in-vitro cytotoxicity studies were also performed using the two drugs in both free and their micellar forms in SKOV3 human ovarian cancer cells using three different cytotoxicity assays...
January 3, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28042941/a-ph-responsive-self-sacrificial-nanotheranostic-agent-for-potential-in-vivo-and-in-vitro-dual-modal-mri-ct-imaging-real-time-and-in-situ-monitoring-of-cancer-therapy
#14
Ludan Yue, Jinlong Wang, Zhichao Dai, Zunfu Hu, Xue Chen, Yafei Qi, Xiuwen Zheng, Dexin Yu
Multifunctional nanotheranostic agents have been highly commended due to the application to realize image-guided cancer therapy. Herein, based on the chemically disordered face centered cubic (fcc) FePt nanoparticles (NPs) and graphene oxide(GO), we develop a pH-responsive FePt-based multifunctional theranostic agent for potential in vivo and in vitro dual modal MRI/CT imaging and in-situ cancer inhibition. The fcc-FePt will release highly active Fe ions due to the low pH in tumor cells, which would catalyze H2O2 decomposition into reactive oxygen species (ROS) within the cells and further induce cancer cell apoptosis...
January 2, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28031049/clinical-and-radiological-features-driving-patient-selection-for-antiangiogenic-therapy-in-non-small-cell-lung-cancer-nsclc
#15
Cesare Gridelli, Andrea Camerini, Giovanni Pappagallo, Angelo Pennella, Michele Anzidei, Massimo Bellomi, Roberta Buosi, Rosario Francesco Grasso
BACKGROUND: The use of antiangiogenic therapy in non-small cell lung cancer (NSCLC) requires thorough evaluation of patient characteristics in order to avoid potential safety issues, particularly pulmonary haemorrhage (PH). The aim of this consensus by a panel of experts was to identify important criteria for the selection of patients with NSCLC who would benefit from antiangiogenic therapy. METHODS: Radiologists and oncologists were selected for the expert panel...
December 28, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28031009/pathobiology-and-therapeutic-implications-of-tumor-acidosis
#16
Jenny Viklund, Sofia Avnet, Angelo De Milito
Drug resistance and therapeutic failure are important causes of disease relapse and progression and may be considered as major obstacles preventing cure of cancer patients. Tumors use a large number of molecular, biochemical and cellular mechanisms to evade chemotherapy and targeted therapy. Important determinants of drug efficacy are the intrinsic pharmacological characteristics of drugs which may be largely affected by the tumor physiology. One feature of solid tumors is the acidic extracellular pH, resulting from metabolic shift and increased metabolic rates combined with low tissue perfusion due to defective vasculature...
December 28, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28027959/polysarcosine-brush-stabilized-gold-nanorods-for-in-vivo-near-infrared-photothermal-tumor-therapy
#17
Hong Zhu, Ying Chen, Fang-Jie Yan, Jin Chen, Xin-Feng Tao, Jun Ling, Bo Yang, Qiao-Jun He, Zheng-Wei Mao
: Gold nanorods (AuNRs) are suitable candidates for photothermal therapy in vivo, because of their excellent ability to transfer near-infrared (NIR) light into heat. However, appropriate surface should be generated on AuNRs before their in vivo application because of the low colloidal stability in complicate biological environment and relatively strong toxicity compared to their pristine stabilizer cetyltrimethylammonium bromide. In the current study, polysarcosine (PS), a non-ionic hydrophilic polypeptoid whose structure is similar to polypeptides, bearing repeating units of natural α-amino acid, was used to stabilize AuNRs due to its excellent hydrophilicity and biocompatibility...
December 24, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28024642/a-theranostic-prodrug-based-on-fret-for-real-time-drug-release-monitoring-in-response-to-biothiols
#18
Yinyang Hu, Fang Zeng
The clinical applications of tradition prodrug are restricted to a certain extent due to its some defects such as side effects, low selectivity and single function. Herein, we designed a theranostic strategy based on the fluorescence resonance energy transfer (FRET) mechanism. The theranostic prodrug was constructed with an anticancer drug camptothecin (CPT), a cleavable linker based on disulfide bonds (SS) and a fluorophore naphthalimide derivative (NAP). For this drug delivery and reporting system (NAP-SS-CPT), FRET occurs between CPT (energy donor) and NAP (energy receptor); and upon cellular uptake by GSH-overexpressing cancer cells, disulfide bonds could be successfully cleaved by the high concentration of GSH, and FRET process was interrupted to achieve dual fluorescence response and specifically release of CPT...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28024357/controllable-co-release-following-near-infrared-light-induced-cleavage-of-iron-carbonyl-derivatized-prussian-blue-nanoparticles-for-co-assisted-synergistic-treatment
#19
Wei-Peng Li, Chia-Hao Su, Ling-Chuan Tsao, Chun-Ting Chang, Ya-Ping Hsu, Chen-Sheng Yeh
Carbon monoxide (CO) causes the dysfunction of mitochondria to induce the apoptosis of cancer cells giving a promising choice as an emerging treatment. The currently reported CO-based complexes still suffer from many limitations. Synthesis of CO-release carriers in the manner of on-demand control is highly anticipated. In this study, we present a near-infrared (NIR) light-responsive CO-delivery nanocarrier, a PEGylated iron carbonyl derivatized Prussian blue (PB) nanoparticle (NP). Taking the structural characteristic containing Fe(3+)-N≡C-Fe(2+) unit, the -CN(-) served as the active sites for the coordination of iron carbonyl, while the surface Fe sites chelated with the amine-functionalized polyethylene glycol (NH2-PEG6000-NH2) to yield PEGylated PB NPs carrying CO...
December 27, 2016: ACS Nano
https://www.readbyqxmd.com/read/28018347/advances-in-therapeutic-fc-engineering-modulation-of-igg-associated-effector-functions-and-serum-half-life
#20
REVIEW
Abhishek Saxena, Donghui Wu
Today, monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers. Efficacy of monoclonal antibodies (mAbs) is achieved through both its antigen-binding fragment (Fab) and crystallizable fragment (Fc). Fab can specifically recognize tumor-associated antigen (TAA) and thus modulate TAA-linked downstream signaling pathways that may lead to the inhibition of tumor growth, induction of tumor apoptosis, and differentiation...
2016: Frontiers in Immunology
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