Yuting He, Xiaolong Chen, Yan Yu, Juan Li, Qiuyue Hu, Chen Xue, Jianan Chen, Shen Shen, Yonggang Luo, Fang Ren, Chao Li, Jie Bao, Jingya Yan, Guowu Qian, Zhigang Ren, Ranran Sun, Guangying Cui
Gallbladder cancer (GBC) is the most general biliary tract malignancy, with poor prognosis due to rapid tumor progression and lack of specific symptoms. Lactate dehydrogenase-A (LDHA) can promote Warburg effect to produce lactate and Adenosine Triphosphate (ATP) in aerobic condition, which contributes to oncogenesis metastasis and drug resistance in various cancers. However, the expression and functional role of LDHA in GBC are largely unknown. We determined that LDHA was over-expressed in GBC tumor tissues compared with normal tissues, which was also an independent prognostic factor for the overall survival of GBC patients by tissue microarrays analysis...
March 23, 2018: Molecular Carcinogenesis