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https://www.readbyqxmd.com/read/28513280/application-of-acoustic-radiation-force-impulse-arfi-elastography-in-imaging-of-delayed-onset-muscle-soreness-doms-a-comparative-analysis-with-3t-mri
#1
Thilo Hotfiel, Marion Kellermann, Bernd Swoboda, Dane Wildner, Tobias Golditz, Casper Grim, Martin Raithel, Michael Uder, Rafael Heiss
CONTEXT: DOMS is one of the most common reasons for impaired muscle performance in sports and is associated with reduced muscle strength and frequently observed both in professional and recreational athletes. OBJECTIVE: To emphasize the diagnostic value of Acoustic Radiation Force Impulse (ARFI) in imaging of Delayed Onset Muscle Soreness by comparing findings to high-resolution 3T MRI T2 weighted sequences. DESIGN: Case series. SETTING: Laboratory environment...
May 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28503793/rectus-abdominis-rhabdomyolysis-report-of-2-cases
#2
Jerome Boyle, Paul Marks, John Read
Exercise-induced rhabdomyolysis is an unusual clinical entity for physicians and one that is frequently misdiagnosed. With the ever-increasing use of sonography by radiologists, sonographers, and sports physicians in the diagnosis of acute muscle injury, recognition of the typical sonographic appearance of rhabdomyolysis is paramount. Current literature using high-resolution ultrasound equipment is limited, with much of the literature offering dated or incongruent descriptions. We describe the sonographic findings of hyperechoic muscle and a hypoechoic halo of edema in 2 proven cases of rectus abdominis rhabdomyolysis after exercise...
May 15, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28488835/incidence-of-injury-and-illness-in-south-african-professional-male-football-players-a-prospective-cohort-study
#3
Helen Bayne, Martin Schwellnus, Dina Janse Van Rensburg, Jhano Botha, Lervasen Pillay
BACKGROUND: Medical illnesses and sports-related injuries both have an effect on athlete health and performance. Epidemiology of injury and illness has been extensively researched during international football tournaments and the European football season. Reports on injury location and severity differ across geographical regions, and there is limited information on injury epidemiology in African football leagues. No studies have investigated the illness burden in football in Africa. METHODS: This was a prospective cohort study involving two football teams over the 10- month duration of the 2015/16 Premier Soccer League in South Africa...
May 9, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28485676/assessment-of-preclinical-liver-and-skeletal-muscle-biomarkers-following-clofibrate-administration-in-wistar-rats
#4
Pierre Maliver, Matthias Festag, Moritz Bennecke, Francois Christen, Balázs Bánfai, Barbara Lenz, Michael Winter
Clofibrate is a known rodent hepatotoxicant classically associated with hepatocellular hypertrophy and increased serum activities of cellular alanine aminotransferase/aspartate aminotransferase (ALT/AST) in the absence of microscopic hepatocellular degeneration. At toxic dose, clofibrate induces liver and skeletal muscle injury. The objective of this study was to assess novel liver and skeletal muscle biomarkers following clofibrate administration in Wistar rats at different dose levels for 7 days. In addition to classical biomarkers, liver injury was assessed by cytokeratin 18 (CK18) cleaved form, high-mobility group box 1, arginase 1 (ARG1), microRNA 122 (miR-122), and glutamate dehydrogenase...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28481224/intermittent-glucocorticoid-steroid-dosing-enhances-muscle-repair-without-eliciting-muscle-atrophy
#5
Mattia Quattrocelli, David Y Barefield, James L Warner, Andy H Vo, Michele Hadhazy, Judy U Earley, Alexis R Demonbreun, Elizabeth M McNally
Glucocorticoid steroids such as prednisone are prescribed for chronic muscle conditions such as Duchenne muscular dystrophy, where their use is associated with prolonged ambulation. The positive effects of chronic steroid treatment in muscular dystrophy are paradoxical because these steroids are also known to trigger muscle atrophy. Chronic steroid use usually involves once-daily dosing, although weekly dosing in children has been suggested for its reduced side effects on behavior. In this work, we tested steroid dosing in mice and found that a single pulse of glucocorticoid steroids improved sarcolemmal repair through increased expression of annexins A1 and A6, which mediate myofiber repair...
May 8, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28480592/slow-myofiber-commitment-by-semaphorin-3a-secreted-from-myogenic-stem-cells
#6
Ryuichi Tatsumi, Takahiro Suzuki, Mai-Khoi Q Do, Yuki Ohya, Judy E Anderson, Ayumi Shibata, Mai Kawaguchi, Shunpei Ohya, Hideaki Ohtsubo, Wataru Mizunoya, Shoko Sawano, Yusuke Komiya, Riho Ichitsubo, Koichi Ojima, Shin-Ichiro Nishimatsu, Tsutomu Nohno, Yutaka Ohsawa, Yoshihide Sunada, Mako Nakamura, Mitsuhiro Furuse, Yoshihide Ikeuchi, Takanori Nishimura, Takeshi Yagi, Ronald E Allen
Recently, we found that resident myogenic stem satellite cells up-regulate a multi-functional secreted protein, semaphorin 3A (Sema3A), exclusively at the early- differentiation phase in response to muscle injury; however, its physiological significance is still unknown. Here we show that Sema3A impacts slow-twitch fiber generation through a signaling pathway, cell-membrane receptor (neuropilin2-plexinA3) → myogenin-myocyte enhancer factor 2D (MEF2D) → slow myosin heavy chain. This novel axis was found by small interfering RNA (siRNA)-transfection experiments in myoblast cultures, which also revealed an additional element that Sema3A-neuropilin1/plexinA1, A2 may enhance slow-fiber formation by activating signals that inhibit fast-myosin expression...
May 7, 2017: Stem Cells
https://www.readbyqxmd.com/read/28477022/downregulated-long-noncoding-rna-aldbgalg0000005049-induces-inflammation-in-chicken-muscle-suffered-from-selenium-deficiency-by-regulating-stearoyl-coa-desaturase
#7
Ruifeng Fan, Changyu Cao, Xia Zhao, Qunxiang Shi, Jinxin Zhao, Shiwen Xu
Long non-coding RNAs (lncRNAs) have been demonstrated to play a pivotal role in proliferation and differentiation of muscles. However, the study on the roles of lncRNAs in Selenium (Se) deficiency induced muscle injury is still unclear. In this study, deep sequencing was performed to profile lncRNAs and mRNAs of the muscles from the Se deficiency (-Se group) and control (C group) chickens. The results revealed that 38 lncRNAs (23 up-regulated and 15 down-regulated) and 687 mRNAs (285 up-regulated and 402 down-regulated) were significantly dysregulated expressed, and the significantly dysregulated pathway including Phagosome, Cardiac muscle contraction, and Peroxisome Proliferator-Activated Receptor (PPAR) in -Se group...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28476900/there-is-strength-in-numbers-for-muscle-injuries-it-is-time-to-establish-an-international-collaborative-registry
#8
EDITORIAL
Nicol van Dyk, Anne D van der Made, Ryan G Timmins, David A Opar, Johannes L Tol
No abstract text is available yet for this article.
May 5, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28476362/editorial-commentary-core-muscle-injuries-or-athletic-pubalgia-finally-the-real-sausage-not-just-the-same-ole-baloney
#9
EDITORIAL
William C Meyers
In their paper "Prevalence of Surgical Repair for Athletic Pubalgia and Impact on Performance in Football Athletes Participating in the National Football League Combine," Knapik et al. cut through the baloney in the literature on "sports hernia" and apply new eyes to the impact of the results of core muscle surgery on young elite athletes trying out for the National Football League (NFL). They found that the players who had surgery did just as well as all the others in and following NFL Combines. Even the players with presumptively residual, MRI findings did well...
May 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28469748/plasma-actin-gelsolin-and-orosomucoid-levels-after-eccentric-exercise
#10
Éva Tékus, Márk Váczi, Zoltán Horváth-Szalai, Andrea Ludány, Tamás Kőszegi, Márta Wilhelm
The present study investigated the acute effect of eccentric exercise on blood plasma actin, gelsolin (GSN) and orosomucoid (AGP) levels in untrained and moderately trained individuals, and their correlation with exercise induced muscle damage (EIMD) markers (CK, intensity of muscle soreness and maximal voluntary contraction torque deficit). Healthy physical education students (6 untrained, 12 moderately trained) participated in this research. Actin, GSN, AGP and CK levels were measured in blood plasma at baseline, immediately, 1 h, 6 h and 24 h post-exercise comprising 90 eccentric quadriceps contractions performed on a dynamometer...
February 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28459795/four-weeks-of-nordic-hamstring-exercise-reduce-muscle-injury-risk-factors-in-young-adults
#11
João Breno de A R Alvares, Vanessa Bernardes Marques, Marco Aurélio Vaz, Bruno Manfredini Baroni
The Nordic hamstring exercise (NHE) is a field-based exercise designed for knee-flexor eccentric strengthening, aimed at muscle strains prevention. However, possible effects of NHE programmes on other hamstring injury risk factors remain unclear. The purpose of this study was to investigate the effects of a NHE training programme on multiple hamstring injury risk factors. Twenty physically active young adults were allocated into two equal sized groups: control group (CG) and training group (TG). The TG was engaged in a 4-week NHE programme, twice a week, 3 sets of 6-10 repetitions; while CG received no exercise intervention...
April 26, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28459396/-mechanical-ventilation-leads-to-remodeling-of-diaphragma-and-soleus-in-rats
#12
Lei Shao, Zhifang Wang, Feifei Wang, Jiaru Huang, Xiaoping Zhu
OBJECTIVE: To investigate the structural response of diaphragm and soleus of the rat after mechanical ventilation (MV), and to explore the specific mechanism of the dysfunction of both muscles. METHODS: Sixteen male Sprague-Dawley (SD) rats were randomly divided into control group and MV group, with 8 rats in each group. Rats in MV group were treated with controlled ventilation and maintained anesthesia, and those in control group were only anesthetized without MV and maintained anesthesia...
January 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28453295/postinjury-exercise-and-platelet-rich-plasma-therapies-improve-skeletal-muscle-healing-in-rats-but-are-not-synergistic-when-combined
#13
Paola Contreras-Muñoz, Joan Ramon Torrella, Xavier Serres, David Rizo-Roca, Meritxell De la Varga, Ginés Viscor, Vicente Martínez-Ibáñez, José Luis Peiró, Tero A H Järvinen, Gil Rodas, Mario Marotta
BACKGROUND: Skeletal muscle injuries are the most common sports-related injury and a major concern in sports medicine. The effect of platelet-rich plasma (PRP) injections on muscle healing is still poorly understood, and current data are inconclusive. PURPOSE: To evaluate the effects of an ultrasound-guided intramuscular PRP injection, administered 24 hours after injury, and/or posttraumatic daily exercise training for 2 weeks on skeletal muscle healing in a recently established rat model of skeletal muscle injury that highly mimics the muscle trauma seen in human athletes...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28439304/is-percutaneous-medial-hamstring-myofascial-lengthening-as-anatomically-effective-and-safe-as-the-open-procedure
#14
T Mansour, J Derienne, M Daher, D Sarraf, Y Zoghbi, I Ghanem
BACKGROUND: Medial hamstring fractional lengthening is commonly performed in children with cerebral palsy (CP) to decrease contracture and/or to improve gait. Percutaneous procedures are gaining more and more popularity, even in the paediatric population, with equivocal results. The purpose of this paper was to determine the efficacy and safety of percutaneous medial hamstring myofascial lengthening (PHL). METHODS: This is a prospective randomised controlled trial including 31 knees from 18 consecutive patients with CP scheduled for medial hamstring lengthening in the setting of multilevel tendon lengthening procedures in a university hospital...
2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28433388/magnetic-resonance-and-diffusion-tensor-imaging-analyses-indicate-heterogeneous-strains-along-human-medial-gastrocnemius-fascicles-caused-by-submaximal-plantar-flexion-activity
#15
Agah Karakuzu, Uluç Pamuk, Cengizhan Ozturk, Burak Acar, Can A Yucesoy
Sarcomere length changes are central to force production and excursion of skeletal muscle. Previous modeling indicates non-uniformity of that if mechanical interaction of muscle with its surrounding muscular and connective tissues is taken into account. Hence, quantifying length changes along the fascicles of activated human muscle in vivo is crucial, but this is lacking due to technical complexities. Combining magnetic resonance imaging deformation analyses and diffusion tensor imaging tractography, the aim was to test the hypothesis that submaximal plantar flexion activity at 15% MVC causes heterogeneous length changes along the fascicles of human medial gastrocnemius (GM) muscle...
April 9, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28417251/irreversible-electroporation-for-the-treatment-of-rabbit-vx2-breast-cancer
#16
Wenlong Zhang, Wei Chai, Jianying Zeng, Jibing Chen, Liqi Bi, Lizhi Niu
Irreversible electroporation (IRE) is considered predominantly as a non-thermal ablative technique that uses electrical fields to permeabilize cell membranes and lead to cell death. In this study, we evaluated the efficacy of IRE in the rabbit VX2 breast cancer model. Thirty-five female New Zealand white rabbits were inoculated against VX2 breast cancer cells. The rabbits were randomly divided into two groups: a control group of 15 rabbits and an IRE treatment group of 20 rabbits. Treatment and treatment outcome were evaluated by computerized tomography (CT) scan (plain or contrast enhanced), tumor growth curves and pathological examination including H&E, TUNEL, PCNA and CD31 staining...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28415893/rem-sleep-deprivation-impairs-muscle-regeneration-in-rats
#17
Marcos Mônico-Neto, Murilo Dáttilo, Daniel Araki Ribeiro, Kil Sun Lee, Marco Túlio de Mello, Sergio Tufik, Hanna Karen Moreira Antunes
INTRODUCTION: The aim was observe the influence of sleep deprivation (SD) and sleep recovery on muscle regeneration process in rats submitted to cryolesion. METHODS: Thirty-two Wistar rats were randomly allocated in four groups: control (CTL), SD for 96 h (SD96), control plus sleep recovery period (CTL + R) and SD96h plus 96 h of sleep recovery (SD96 + R). The animals were submitted to muscle injury by cryolesioning, after to SD and sleep recovery. RESULTS: The major outcomes of this study were the reduction of muscular IGF-1 in both legs (injured and uninjured) and a delay in muscle regeneration process of animals submitted to SD compared to animals that slept, with increase connective tissue, inflammatory infiltrate and minor muscle fibers...
April 17, 2017: Growth Factors
https://www.readbyqxmd.com/read/28414312/high-resolution-myogenic-lineage-mapping-by-single-cell-mass-cytometry
#18
Ermelinda Porpiglia, Nikolay Samusik, Andrew Tri Van Ho, Benjamin D Cosgrove, Thach Mai, Kara L Davis, Astraea Jager, Garry P Nolan, Sean C Bendall, Wendy J Fantl, Helen M Blau
Muscle regeneration is a dynamic process during which cell state and identity change over time. A major roadblock has been a lack of tools to resolve a myogenic progression in vivo. Here we capitalize on a transformative technology, single-cell mass cytometry (CyTOF), to identify in vivo skeletal muscle stem cell and previously unrecognized progenitor populations that precede differentiation. We discovered two cell surface markers, CD9 and CD104, whose combined expression enabled in vivo identification and prospective isolation of stem and progenitor cells...
May 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28413812/quantitative-3d-time-lapse-imaging-of-muscle-progenitors-in-skeletal-muscle-of-live-mice
#19
Micah T Webster, Tyler Harvey, Chen-Ming Fan
For non-optically clear mammalian tissues, it is now possible to use multi-photon microscopy to penetrate deep into the tissue and obtain detailed single cell images in a live animal, i.e., intravital imaging. This technique is in principle applicable to any fluorescently marked cell, and we have employed it to observe stem cells during the regenerative process. Stem cell-mediated skeletal muscle regeneration in the mouse model has been classically studied at specific time points by sacrificing the animal and harvesting the muscle tissue for downstream analyses...
December 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28409883/melanocortin-4-receptor-activation-attenuates-mitochondrial-dysfunction-in-skeletal-muscle-of-diabetic-rats
#20
Hao-Hao Zhang, Jiao Liu, Gui-Jun Qin, Xia-Lian Li, Pei-Jie Du, Xiao Hao, Tian-Tian Tian, Jing- Wu, Meng- Yun, Yan-Hui Bai
Backgroud: A previous study has confirmed that the central melanocortin system was able to mediate skeletal muscle AMP-activated protein kinase (AMPK) activation in mice fed a high-fat diet, while activation of the AMPK signaling pathway significantly induced mitochondrial biogenesis. Our hypothesis was that melanocortin 4 receptor (MC4R) was involved in the development of skeletal muscle injury in diabetic rats. METHODS: In this study, we treated diabetic rats intracerebroventricularly with MC4R agonist R027-3225 or antagonist SHU9119, respectively...
April 14, 2017: Journal of Cellular Biochemistry
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