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https://www.readbyqxmd.com/read/28332979/the-perk-arm-of-the-unfolded-protein-response-regulates-satellite-cell-mediated-skeletal-muscle-regeneration
#1
Guangyan Xiong, Sajedah M Hindi, Aman K Mann, Yann Simon Gallot, Kyle R Bohnert, Douglas R Cavener, Scott R Whittemore, Ashok Kumar
Regeneration of skeletal muscle in adults is mediated by satellite stem cells. Accumulation of misfolded proteins triggers endoplasmic reticulum stress that leads to unfolded protein response (UPR). The UPR is relayed to the cell through the activation of PERK, IRE1/XBP1, and ATF6. Here, we demonstrate that levels of PERK and IRE1 are increased in satellite cells upon muscle injury. Inhibition of PERK, but not the IRE1 arm of the UPR in satellite cells inhibits myofiber regeneration in adult mice. PERK is essential for the survival and differentiation of activated satellite cells into the myogenic lineage...
March 23, 2017: ELife
https://www.readbyqxmd.com/read/28332112/perspectives-on-exertional-rhabdomyolysis
#2
REVIEW
Eric S Rawson, Priscilla M Clarkson, Mark A Tarnopolsky
Exertional (exercise-induced) rhabdomyolysis is a potentially life threatening condition that has been the subject of research, intense discussion, and media attention. The causes of rhabdomyolysis are numerous and can include direct muscle injury, unaccustomed exercise, ischemia, extreme temperatures, electrolyte abnormalities, endocrinologic conditions, genetic disorders, autoimmune disorders, infections, drugs, toxins, and venoms. The objective of this article is to review the literature on exertional rhabdomyolysis, identify precipitating factors, and examine the role of the dietary supplement creatine monohydrate...
March 22, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28326040/effects-of-topical-icing-on-inflammation-angiogenesis-revascularization-and-myofiber-regeneration-in-skeletal-muscle-following-contusion-injury
#3
Daniel P Singh, Zohreh Barani Lonbani, Maria A Woodruff, Tony J Parker, Roland Steck, Jonathan M Peake
Contusion injuries in skeletal muscle commonly occur in contact sport and vehicular and industrial workplace accidents. Icing has traditionally been used to treat such injuries under the premise that it alleviates pain, reduces tissue metabolism, and modifies vascular responses to decrease swelling. Previous research has examined the effects of icing on inflammation and microcirculatory dynamics following muscle injury. However, whether icing influences angiogenesis, collateral vessel growth, or myofiber regeneration remains unknown...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28323694/assessment-of-paraspinal-muscle-cross-sectional-area-after-lumbar-decompression-minimally-invasive-versus-open-approaches
#4
Lacey E Bresnahan, Justin S Smith, Alfred T Ogden, Steven Quinn, George R Cybulski, Narina Simonian, Raghu N Natarajan, Richard D Fessler, Richard G Fessler
STUDY DESIGN: A retrospective, blinded analysis of imaging studies. SUMMARY OF BACKGROUND DATA: To evaluate changes in paraspinal muscle cross-sectional area (CSA) after surgical treatment for lumbar stenosis and to compare these changes between minimally invasive and standard open approaches. The open approach to lumbar stenosis is effective, but it involves retraction and resection of muscle from the spinous process, which can result in ischemia and denervation of paraspinal musculature and may lead to muscle atrophy and pain...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28315479/biopsychosocial-influence-on-shoulder-pain-rationale-and-protocol-for-a-pre-clinical-trial
#5
Steven Z George, Roland Staud, Paul A Borsa, Samuel S Wu, Margaret R Wallace, Warren H Greenfield, Lauren N Mackie, Roger B Fillingim
BACKGROUND: Chronic musculoskeletal pain conditions are a prevalent and disabling problem. Preventing chronic musculoskeletal pain requires multifactorial treatment approaches that address its complex etiology. Prior cohort studies identified a high risk subgroup comprised of variation in COMT genotype and pain catastrophizing. This subgroup had increased chance of heightened pain responses (in a pre-clinical model) and higher 12month post-operatives pain intensity ratings (in a clinical model)...
March 14, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28293722/pattern-of-cardiotoxin-induced-muscle-remodeling-in-distinct-tlr-4-deficient-mouse-strains
#6
Eustáquio Luiz Paiva-Oliveira, Rafael Ferreira da Silva, Maria Bellio, Thereza Quirico-Santos, Jussara Lagrota-Candido
Tissue damage triggers innate immune response mediated by Toll-like receptor 4 (TLR) that recognizes endogenous host danger molecules associated with cell death and tissue inflammation, although the precise role of TLR-4 signaling in muscle tissue repair is still uncertain. Previously, we observed that TLR-4 exerted a protective effect preventing excessive muscular damage induced by Bothrops jararacussu crude venom. This study aimed to evaluate the involvement of TLR-4 at early stages of muscular tissue remodeling in distinct mouse strains after injection of purified snake venom...
March 14, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28291543/cell-membrane-integrity-and-revascularization-the-possible-functional-mechanism-of-ischemic-preconditioning-for-skeletal-muscle-protection-against-ischemic-reperfusion-injury
#7
Yang Hong, Bin Zhang, Ling Yu, Shan-Shan Duan
BACKGROUND: The purpose of this paper was to evaluate whether ischemic preconditioning (IPC) could make protective effects against skeletal muscle injuries induced by ischemic-reperfusion (I/R). METHODS: Eighteen rats were randomly divided into three groups of 6 subjects each: control group, I/R group, and IPC group. Thigh root ischemia of rats in the I/R group was induced by 3h ischemia and 24h reperfusion. IPC was applied by 3 periods of 15min ischemia/15min reperfusion prior to ischemia...
March 10, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28288352/effects-of-dechlorane-plus-exposure-on-axonal-growth-musculature-and-motor-behavior-in-embryo-larval-zebrafish
#8
Xiangping Chen, Qiaoxiang Dong, Yuanhong Chen, Zhenxuan Zhang, Changjiang Huang, Yaxian Zhu, Yong Zhang
Developmental neurobehavioral toxicity of Dechlorane Plus (DP) was investigated using the embryo-larval stages of zebrafish (Danio rerio). Normal fertilized embryos were waterborne exposed to DP at 15, 30, 60 μg/L beginning from 6 h post-fertilization (hpf). Larval teratology, motor activity, motoneuron axonal growth and muscle morphology were assessed at different developmental stages. Results showed that DP exposure significantly altered embryonic spontaneous movement, reduced touch-induced movement and free-swimming speed and decreased swimming speed of larvae in response to dark stimulation...
March 10, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28280975/the-effect-of-nordic-hamstring-strength-training-on-muscle-architecture-stiffness-and-strength
#9
Kayla D Seymore, Zachary J Domire, Paul DeVita, Patrick M Rider, Anthony S Kulas
PURPOSE: Hamstring strain injury is a frequent and serious injury in competitive and recreational sports. While Nordic hamstring (NH) eccentric strength training is an effective hamstring injury-prevention method, the protective mechanism of this exercise is not understood. Strength training increases muscle strength, but also alters muscle architecture and stiffness; all three factors may be associated with reducing muscle injuries. The purpose of this study was to examine the effects of NH eccentric strength training on hamstring muscle architecture, stiffness, and strength...
March 9, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28269022/split-belt-controllable-treadmill-with-differential-velocity-based-fall-stimulation-and-motion-analysis
#10
Yasutaka Nakashima, Hiroki Noutsuka, Takanori Fukui, Motoji Yamamoto
Amid trends toward aging populations in developed nations, the number of people requiring nursing care has increased markedly. Slips and falls during ordinary daily activities are a common cause of fractured bones and muscle injury. Several studies have analyzed the movements produced by artificially generated slip and fall stimuli, but few have investigated these stimuli. We analyzed lower-limb motion following a slip and fall stimulus produced using a pulled free-walking system consisting of a controllable split-belt treadmill, where a speed difference between the belts could be applied to produce a slipping motion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267537/intra-and-interrater-reliability-of-three-different-mri-grading-and-classification-systems-after-acute-hamstring-injuries
#11
Arnlaug Wangensteen, Johannes L Tol, Frank W Roemer, Roald Bahr, H Paul Dijkstra, Michel D Crema, Abdulaziz Farooq, Ali Guermazi
OBJECTIVE: To assess and compare the intra- and interrater reliability of three different MRI grading and classification systems after acute hamstring injury. METHODS: Male athletes (n=40) with clinical diagnosis of acute hamstring injury and MRI ≤5days were selected from a prospective cohort. Two radiologists independently evaluated the MRIs using standardised scoring form including the modified Peetrons grading system, the Chan acute muscle strain injury classification and the British Athletics Muscle Injury Classification...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28263783/establishment-of-a-novel-mouse-model-for-pioglitazone-induced-skeletal-muscle-injury
#12
Sho Akai, Shingo Oda, Tsuyoshi Yokoi
Skeletal muscle (SKM) injury is one of the major safety concerns in risk assessment for drug development. However, no appropriate pre-clinical animal model exists to evaluate drug-induced SKM injury except that caused by fibrates and statins. Thiazolidinedione, a PPARγ agonistic drug for type 2 diabetes mellitus, is widely used clinically but can induce adverse effects such as hepatotoxicity and SKM injury, as has been reported in recent decades. Moreover, thiazolidinedione-induced SKM injury has only been reported in humans, and no evidence of SKM injury has been observed in rodents...
March 2, 2017: Toxicology
https://www.readbyqxmd.com/read/28259848/calf-muscle-strain-injuries-in-sport-a-systematic-review-of-risk-factors-for-injury
#13
REVIEW
Brady Green, Tania Pizzari
OBJECTIVE: To systematically review the literature to identify risk factors for calf strain injury, and to direct future research into calf muscle injuries. DESIGN: Systematic review DATA SOURCES: Database searches conducted for Medline, CINAHL, EMBASE, AMED, AUSPORT, SportDiscus, PEDro and Cochrane Library. Manual reference checks, ahead of press searches, citation tracking. From inception to June 2016. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Studies evaluating and presenting data related to intrinsic or extrinsic risk factors for sustaining future calf injury...
March 4, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28259568/chloroquine-improves-the-response-to-ischemic-muscle-injury-and-increases-hmgb1-after-arterial-ligation
#14
Jun Xu, Xiangdong Cui, Jiehua Li, Panagiotis Koutakis, Iraklis Pipinos, Edith Tzeng, Alex Chen, Ulka Sachdev
OBJECTIVE: We have previously shown that exogenous administration of the nuclear protein high mobility group box 1 (HMGB1) improves angiogenesis after tissue ischemia. Antagonizing HMGB1 prolongs muscle necrosis and deters regeneration. In this study, we evaluated HMGB1 expression in peripheral arterial disease (PAD) and the mechanisms that promote its release in a murine model of hindlimb ischemia. Specifically, we investigated how chloroquine (CQ), a commonly employed disease-modifying antirheumatic drug, promotes HMGB1 release from muscle...
March 1, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28255772/isolation-culture-and-biological-characteristics-of-multipotent-porcine-skeletal-muscle-satellite-cells
#15
Jinjuan Yang, Hao Liu, Kunfu Wang, Lu Li, Hongyi Yuan, Xueting Liu, Yingjie Liu, Weijun Guan
Skeletal muscle has a huge regenerative potential for postnatal muscle growth and repair, which mainly depends on a kind of muscle progenitor cell population, called satellite cell. Nowadays, the majority of satellite cells were obtained from human, mouse, rat and other animals but rarely from pig. In this article, the porcine skeletal muscle satellite cells were isolated and cultured in vitro. The expression of surface markers of satellite cells was detected by immunofluorescence and RT-PCR assays. The differentiation capacity was assessed by inducing satellite cells into adipocytes, myoblasts and osteoblasts...
March 2, 2017: Cell and Tissue Banking
https://www.readbyqxmd.com/read/28252568/time-course-of-inflammatory-gene-expression-following-crush-injury-in-murine-skeletal-muscle
#16
Joachim G Voss, Ayelet Goldshmid Shagal, Joyce M Tsuji, James W MacDonald, Theo K Bammler, Fred M Farin, Barbara St Pierre Schneider
BACKGROUND: Early inflammation and secretion of proinflammatory cytokines such as IL-1β, IL-6, and TNF-α act as the key drivers to regulate inflammation after muscle injury. However, the effects of these key proinflammatory drivers in a noninvasive crush injury model are not well known. Understanding these effects is important for treating crush injuries that occur during natural disasters and military conflicts. PURPOSE: We studied the timed mRNA expression of IL-1β, IL-6, and TNF-α in a noninvasive murine crush injury model to further understand their impact on proinflammatory cytokine pathways that are activated within the first 48 hours after a crush muscle injury...
March 2017: Nursing Research
https://www.readbyqxmd.com/read/28252476/athletic-hip-injuries
#17
T Sean Lynch, Asheesh Bedi, Christopher M Larson
Historically, athletic hip injuries have garnered little attention; however, these injuries account for approximately 6% of all sports injuries and their prevalence is increasing. At times, the diagnosis and management of hip injuries can be challenging and elusive for the team physician. Hip injuries are seen in high-level athletes who participate in cutting and pivoting sports that require rapid acceleration and deceleration. Described previously as the "sports hip triad," these injuries consist of adductor strains, osteitis pubis, athletic pubalgia, or core muscle injury, often with underlying range-of-motion limitations secondary to femoroacetabular impingement...
April 2017: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/28249782/aldh2-restores-exhaustive-exercise-induced-mitochondrial-dysfunction-in-skeletal-muscle
#18
Qiuping Zhang, Jianheng Zheng, Jun Qiu, Xiahong Wu, Yangshuo Xu, Weili Shen, Mengwei Sun
BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is highly expressed in heart and skeletal muscles, and is the major enzyme that metabolizes acetaldehyde and toxic aldehydes. The cardioprotective effects of ALDH2 during cardiac ischemia/reperfusion injury have been recognized. However, less is known about the function of ALDH2 in skeletal muscle. This study was designed to evaluate the effect of ALDH2 on exhaustive exercise-induced skeletal muscle injury. METHODS: We created transgenic mice expressing ALDH2 in skeletal muscles...
April 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28246078/return-to-play-criteria-after-hamstring-muscle-injury-in-professional-football-a-delphi-consensus-study
#19
Mattia Zambaldi, Ian Beasley, Alison Rushton
BACKGROUND: Hamstring muscle injury (HMI) is the most common injury in professional football and has a high re-injury rate. Despite this, there are no validated criteria to support return to play (RTP) decisions. AIM: To use the Delphi method to reach expert consensus on RTP criteria after HMI in professional football. METHODS: All professional football clubs in England (n=92) were invited to participate in a 3-round Delphi study. Round 1 requested a list of criteria used for RTP decisions after HMI...
February 28, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28245256/effects-of-delayed-nsaid-administration-after-experimental-eccentric-contraction-injury-a-cellular-and-proteomics-study
#20
Amy E Bryant, Michael J Aldape, Clifford R Bayer, Eva J Katahira, Laura Bond, Carrie D Nicora, Thomas L Fillmore, Therese R W Clauss, Thomas O Metz, Bobbie-Jo Webb-Robertson, Dennis L Stevens
BACKGROUND: Acute muscle injuries are exceedingly common and non-steroidal anti-inflammatory drugs (NSAIDs) are widely consumed to reduce the associated inflammation, swelling and pain that peak 1-2 days post-injury. While prophylactic use or early administration of NSAIDs has been shown to delay muscle regeneration and contribute to loss of muscle strength after healing, little is known about the effects of delayed NSAID use. Further, NSAID use following non-penetrating injury has been associated with increased risk and severity of infection, including that due to group A streptococcus, though the mechanisms remain to be elucidated...
2017: PloS One
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