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"muscle injury"

Eun Ju Lee, Joo Hyun Nam, Inho Choi
Fibromodulin (FMOD) is a proteoglycan present in extracellular matrix (ECM). Based on our previous findings that FMOD controls myoblast differentiation by regulating the gene expressions of collagen type I alpha 1 (COL1α1) and integral membrane protein 2 A (Itm2a), we undertook this study to investigate relationships between FMOD and calcium channels and to understand further the mechanism by which they control myoblast differentiation. Gene expression studies and luciferase reporter assays showed FMOD affected calcium channel gene expressions by regulating calcium channel gene promoter, and patch-clamp experiments showed both L- and T-type calcium channel currents were almost undetectable in FMOD knocked down cells...
June 15, 2018: Biochemical and Biophysical Research Communications
Chengchuang Song, Jian Wang, Yilei Ma, Zhaoxin Yang, Dong Dong, Hui Li, Jiameng Yang, Yongzhen Huang, Martin Plath, Yun Ma, Hong Chen
Long noncoding RNAs (lncRNAs) are involved in the regulation of skeletal muscle development. In the present study, differentially expressed lncRNAs were identified from RNA-seq data derived from myoblasts and myotubes. We conducted studies to elucidate the function and molecular mechanism of action of Linc-smad7 during skeletal muscle development. Our findings show that Linc-smad7 is upregulated during the early phase of myoblasts differentiation. In in vitro studies, we showed that overexpression of Linc-smad7 promoted the arrest of myoblasts in G1 phase, inhibited DNA replication, and induced myoblast differentiation...
June 18, 2018: Epigenetics: Official Journal of the DNA Methylation Society
Annia Schreiber, Michele Bertoni, Ewan C Goligher
Both limb muscle weakness and respiratory muscle weakness are exceedingly common in critically ill patients. Respiratory muscle weakness prolongs ventilator dependence, predisposing to nosocomial complications and death. Limb muscle weakness persists for months after discharge from intensive care and results in poor long-term functional status and quality of life. Major mechanisms of muscle injury include critical illness polymyoneuropathy, sepsis, pharmacologic exposures, metabolic derangements, and excessive muscle loading and unloading...
July 2018: Critical Care Clinics
Rui-Feng Fan, Chang-Yu Cao, Meng-Hao Chen, Qun-Xiang Shi, Shi-Wen Xu
Selenoprotein K (SELENOK) is primarily observed in the endoplasmic reticulum, and serves to maintain the normal physiological functions of skeletal muscle. Skeletal muscle development and regeneration are associated with significant changes in the expression of specific microRNAs (miRNAs). Downregulated SELENOK expression is observed in chicken muscles deficient of Se. However, the mechanisms of miRNA regulation of SELENOK expression remain elusive. Here, deep sequencing was used to detect the miRNA profiles of muscle in Se deficient (-Se group) and normal (C group) chickens...
June 15, 2018: Metallomics: Integrated Biometal Science
Zhining Wen, Yu Liang, Yingyi Hao, Brian Delavan, Ruili Huang, Mike Mikailov, Weida Tong, Menglong Li, Zhichao Liu
Drug-induced rhabdomyolysis (DIR) is an idiosyncratic and fatal adverse drug reaction (ADR) characterized in severe muscle injuries accompanied by multiple-organ failure. Limited knowledge regarding the pathophysiology of rhabdomyolysis is the main obstacle to developing early biomarkers and prevention strategies. Given the lack of a centralized data resource to curate, organize, and standardize widespread DIR information, here we present a Drug-Induced Rhabdomyolysis Atlas (DIRA) that provides DIR-related information, including: a classification scheme for DIR based on drug labeling information; postmarketing surveillance data of DIR; and DIR drug property information...
June 11, 2018: Drug Discovery Today
Andrea Paolini, Saleh Omairi, Robert Mitchell, Danielle Vaughan, Antonios Matsakas, Sakthivel Vaiyapuri, Thomas Ricketts, David C Rubinsztein, Ketan Patel
Autophagy has been implicated as a major factor in the development of a number of diseases of skeletal muscle. However, its role in skeletal muscle homeostasis is still evolving. We examined skeletal muscle architecture in a mouse model, Atg16L1, where autophagy is attenuated but importantly still present. We show that muscle fibres from Atg16L1 mice were smaller than wild-type counterparts, proving a role for this process in the growth of these cells. We show that mild attenuation of autophagy results in accelerated muscle loss during the initial phase of acute starvation...
June 13, 2018: Scientific Reports
Julien Siracusa, Nathalie Koulmann, Marie-Emmanuelle Goriot, Stéphanie Bourdon, Antoine Sourdrille, Sébastien Banzet
MicroRNA (miRNA) are found in numerous biofluids including blood and are considered a new class of biomarkers. In several animal models as well as in human diseases, they are interesting circulating markers of acute or chronic tissue injury. This article provides additional data related to a previous research article entitled "Circulating miRNAs as biomarkers of acute muscle damage in rats" by Siracusa et al. (2016) [1]. The data were obtained by RT-qPCR performed on plasma of rats exposed to acute muscle damage...
June 2018: Data in Brief
Ann Rancourt, Sébastien S Dufresne, Guillaume St-Pierre, Julie-Christine Lévesque, Haruka Nakamura, Yodai Kikuchi, Masahiko S Satoh, Jérôme Frenette, Sachiko Sato
The muscle membrane, sarcolemma, must be firmly attached to the basal lamina. The failure of proper attachment results in muscle injury, which is the underlying cause of Duchenne muscular dystrophy (DMD), in which mutations in the dystrophin gene disrupts the firm adhesion. In patients with DMD, even moderate contraction causes damage, leading to progressive muscle degeneration. The damaged muscles are repaired through myogenesis. Consequently, myogenesis is highly active in patients with DMD, and the repeated activation of myogenesis leads to the exhaustion of the myogenic stem cells...
June 12, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Sun-Min Lee, Jung-Hoon Lee
RATIONALE: Football players are at high risk for lower extremity injuries because they turn on an axis of rotation, turn while decelerating, and repeatedly jump and land. One of the most common sites of injury is the knee. PATIENT CONCERNS: A 25-year-old amateur university football player with pain in the knee medial area (Visual Analog Scale [VAS] score of 6/10), a hamstring muscle injury (VAS of 5/10), and a Tegner Activity Scale level of 3. DIAGNOSES: He was diagnosed as hamstring muscle injury and traumatic knee pain...
June 2018: Medicine (Baltimore)
Johann F Coetzee, Michael D Kleinhenz, Drew R Magstadt, Vickie L Cooper, Larry W Wulf, Nicholas K Van Engen, Joseph S Smith, Nathan Rand, Butch KuKanich, Patrick J Gorden
Remote drug delivery (RDD) using pneumatic darts has become more prevalent in situations where cattle handling facilities are not available. The objective of this study was to compare the effect of pneumatic dart delivery and subcutaneous injection of tulathromycin on plasma pharmacokinetics and biomarkers of inflammation, stress, and muscle injury in calves. Twenty-three castrated-male Holstein calves, approximately 10 months of age with an average weight of 378 ± 6.49 kg, were randomly assigned to one of two groups...
June 5, 2018: Journal of Animal Science
Julien Pottecher, Chris Adamopoulos, Anne Lejay, Jamal Bouitbir, Anne-Laure Charles, Alain Meyer, Mervyn Singer, Valerie Wolff, Pierre Diemunsch, Gilles Laverny, Daniel Metzger, Bernard Geny
Objectives: Diabetic patients respond poorly to revascularization for peripheral arterial disease (PAD) but the underlying mechanisms are not well understood. We aimed to determine whether diabetes worsens ischemia-reperfusion (IR)-induced muscle dysfunction and the involvement of endogenous protective kinases in this process. Materials and Methods: Streptozotocin-induced diabetic and non-diabetic rats were randomized to control or to IR injury (3 h of aortic cross-clamping and 2 h of reperfusion). Mitochondrial respiration, reactive oxygen species (ROS) production, protein levels of superoxide dismutase (SOD2) and endogenous protective kinases (RISK and SAFE pathways) were investigated in rat gastrocnemius, together with upstream (GSK-3β) and downstream (cleaved caspase-3) effectors of apoptosis...
2018: Frontiers in Physiology
Gian Nicola Bisciotti, Piero Volpi, Maurizio Amato, Giampietro Alberti, Francesco Allegra, Alessandro Aprato, Matteo Artina, Alessio Auci, Corrado Bait, Gian Matteo Bastieri, Luca Balzarini, Andrea Belli, Gianandrea Bellini, Pierfrancesco Bettinsoli, Alessandro Bisciotti, Andrea Bisciotti, Stefano Bona, Lorenzo Brambilla, Marco Bresciani, Michele Buffoli, Filippo Calanna, Gian Luigi Canata, Davide Cardinali, Giulia Carimati, Gabriella Cassaghi, Enrico Cautero, Emanuele Cena, Barbara Corradini, Alessandro Corsini, Cristina D'Agostino, Massimo De Donato, Giacomo Delle Rose, Francesco Di Marzo, Francesco Di Pietto, Drapchind Enrica, Cristiano Eirale, Luigi Febbrari, Paolo Ferrua, Andrea Foglia, Alberto Galbiati, Alberto Gheza, Carlo Giammattei, Francesco Masia, Gianluca Melegati, Biagio Moretti, Lorenzo Moretti, Roberto Niccolai, Antonio Orgiani, Claudio Orizio, Andrea Pantalone, Federica Parra, Paolo Patroni, Maria Teresa Pereira Ruiz, Marzio Perri, Stefano Petrillo, Luca Pulici, Alessandro Quaglia, Luca Ricciotti, Francesco Rosa, Nicola Sasso, Claudio Sprenger, Chiara Tarantola, Fabio Gianpaolo Tenconi, Fabio Tosi, Michele Trainini, Agostino Tucciarone, Ali Yekdah, Zarko Vuckovic, Raul Zini, Karim Chamari
Provide the state of the art concerning (1) biology and aetiology, (2) classification, (3) clinical assessment and (4) conservative treatment of lower limb muscle injuries (MI) in athletes. Seventy international experts with different medical backgrounds participated in the consensus conference. They discussed and approved a consensus composed of four sections which are presented in these documents. This paper represents a synthesis of the consensus conference, the following four sections are discussed: (i) The biology and aetiology of MIs...
2018: BMJ Open Sport & Exercise Medicine
Mark A Anderson, F Joseph Simeone, William E Palmer, Connie Y Chang
OBJECTIVE: To correlate MRI findings of patients with posterior cruciate ligament (PCL) injury and surgical management. MATERIALS AND METHODS: A retrospective search yielded 79 acute PCL injuries (36 ± 16 years old, 21 F, 58 M). Two independent readers graded PCL tear location (proximal, middle, or distal third) and severity (low-grade or high-grade partial/complete) and evaluated injury of other knee structures. When available, operative reports were examined and the performed surgical procedure was compared with injury grade, location, and presence of associated injuries...
June 1, 2018: Skeletal Radiology
Yaying Sun, Hui Wang, Yan Li, Shaohua Liu, Jiwu Chen, Hao Ying
Fibrosis is common after skeletal muscle injury, undermining tissue regeneration and function. The mechanism underlying skeletal muscle fibrosis remains unveiled. Transforming growth factor-β/Smad signaling pathway is supposed to play a pivotal role. However, how microRNAs interact with transforming growth factor-β/Smad-related muscle fibrosis remains unclear. We showed that microRNA (miR)-24-3p and miR-122-5p declined in skeletal muscle fibrosis, which was a consequence of transforming growth factor-β. Upregulating Smad4 suppressed two microRNAs, whereas inhibiting Smad4 elevated microRNAs...
June 1, 2018: Molecular Therapy. Nucleic Acids
Alessandro Vidoni, Mark Gillett, Rajesh Botchu, Steven James
Injuries to the lower limb muscles are a common cause of absence from training and competition in athletes. The different muscular groups of the thigh and leg are involved in various activities with kicking and sprinting being responsible for the largest number of injuries. The muscle acts on bone through the tendon and the fascia. The failure of one or more of these structures results in various degrees of loss of function of the muscle(s) involved. Usually, the point of weakness is the interface between different structures with different elastic properties (myofascial, myotendinous, avulsion)...
July 2018: European Journal of Radiology
Juan Liu, Dominik Saul, Kai Oliver Böker, Jennifer Ernst, Wolfgang Lehman, Arndt F Schilling
Skeletal muscle has the capacity of regeneration after injury. However, for large volumes of muscle loss, this regeneration needs interventional support. Consequently, muscle injury provides an ongoing reconstructive and regenerative challenge in clinical work. To promote muscle repair and regeneration, different strategies have been developed within the last century and especially during the last few decades, including surgical techniques, physical therapy, biomaterials, and muscular tissue engineering as well as cell therapy...
2018: BioMed Research International
Meryl A Simon, Emily M Tibbits, Guillaume L Hoareau, Anders J Davidson, Erik S DeSoucy, E Robert Faulconer, J Kevin Grayson, Lucas P Neff, M Austin Johnson, Timothy K Williams
BACKGROUND: New strategies to mitigate ischemia during REBOA and to prolong its maximal duration are needed. We hypothesized that simple external cooling of the hind limbs would decrease ischemia-reperfusion injury following prolonged Zone 3 REBOA. METHODS: 12 swine were anesthetized, instrumented, splenectomized then underwent 15% total blood volume hemorrhage. Animals were randomized to hypothermia or control followed by 4 hours of Zone 3 REBOA, resuscitation with shed blood, and 3 hours of critical care...
May 29, 2018: Journal of Trauma and Acute Care Surgery
Albert Pérez-Bellmunt, Oriol Casasayas, Raul Navarro, Mathias Simon, Juan C Martin, Cristina Pérez-Corbella, Marc Blasi, Sara Ortiz, Pedro Álvarez, Laura Pacheco
BACKGROUND: Hamstring muscle injuries are common in the sports field, with lack of hamstring flexibility being a risk factor. Stretching the hamstring muscles is an important part of the training and rehabilitation programs used to prevent or treat injury and improve performance. We aim to compare the immediate and follow-up effect on hamstring muscle flexibility between 2 different stretching protocols, proprioceptive neuromuscular facilitation (PNF) stretching and PNF stretching combined with electrostimulation...
May 29, 2018: Journal of Sports Medicine and Physical Fitness
Yosuke Nakatani, Masayuki Kurose, Shiho Shimizu, Mana Hasegawa, Nobuyuki Ikeda, Kensuke Yamamura, Ritsuo Takagi, Keiichiro Okamoto
This study aimed to determine whether psychophysical stress conditionings had facilitatory effects on masseter muscle nociception in the central nervous system via serotonergic mechanisms in rats. Two experiments were conducted to assess: (1) whether repeated forced swim stress for 3 days increased the number of Fos-positive neurons evoked by masseter muscle injury due to formalin injection; and (2) whether serotonin-reuptake inhibitor, fluoxetine, administered daily after each stress conditioning, had modulatory roles on Fos expression...
May 28, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Seward B Rutkove, Hyeuknam Kwon, Maria Guasch, Jim S Wu, Benjamin Sanchez
OBJECTIVE: To use a standard modeling approach to evaluate the feasibility of imaging healthy and diseased skeletal muscle at the microscopic scale with a novel electrical impedance imaging (EII) needle. METHODS: We modeled an EII needle containing 16 impedance electrodes arranged circumferentially around the shaft of a non-conductive 19-gauge needle in 4 planes. We then combined the finite element method approach with a reconstruction algorithm to create imaging simulations of the electrical properties of the triceps brachii by localized intramuscular fat (as might be seen in any chronic neuromuscular disease) and by localized edema (as in inflammatory myositis or after direct muscle injury)...
May 15, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
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