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https://www.readbyqxmd.com/read/27913649/identification-and-function-of-fibrocytes-in-skeletal-muscle-injury-repair-and-muscular-dystrophy
#1
Xingyu Wang, Wanming Zhao, Richard M Ransohoff, Lan Zhou
We identified and characterized the function of CD45(+)/collagen I(+) fibrocytes in acutely injured skeletal muscle of wild-type (WT) and Ccr2(-/-) mice, and in quadriceps and diaphragm muscles of mdx(5cv) mice, a mouse model for Duchenne muscular dystrophy. Fibrocytes were not detected in peripheral blood of WT mice after acute muscle injury or mdx(5cv) mice. Fibrocytes were detected in acutely injured muscles and in mdx(5cv) quadriceps and diaphragm muscles. These cells expressed F4/80 and CCR2, and they were mostly Ly6C(lo) They expressed a low level of collagens but a high level of profibrotic growth factors as compared with i...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27909917/strength-training-prior-to-muscle-injury-potentiates-low-level-laser-therapy-lllt-induced-muscle-regeneration
#2
Samuel Rodrigues Lourenço Morais, Alexandre Ginei Goya, Úrsula Urias, Paulo Roberto Jannig, Aline Villa Nova Bacurau, Wagner Garcez Mello, Paula Lazilha Faleiros, Sandra Helena Penha Oliveira, Valdir Gouveia Garcia, Edilson Ervolino, Patricia Chakur Brum, Rita Cássia Menegati Dornelles
We evaluated whether strength training (ST) performed prior to skeletal muscle cryolesion would act as a preconditioning, improving skeletal muscle regeneration and responsiveness to low-level laser therapy (LLLT). Wistar rats were randomly assigned into non-exercised (NE), NE plus muscle lesion (NE + LE), NE + LE plus LLLT (NE + LE + LLLT), strength training (ST), ST + LE, and ST + LE + LLLT. The animals performed 10 weeks of ST (climbing ladder; 3× week; 80% overload). Forty-eight hours after the last ST session, tibialis anterior (TA) cryolesion was induced and LLLT (InGaAlP, 660 nm, 0...
December 1, 2016: Lasers in Medical Science
https://www.readbyqxmd.com/read/27906113/dystrophin-restoration-therapy-improves-both-the-reduced-excitability-and-the-force-drop-induced-by-lengthening-contractions-in-dystrophic-mdx-skeletal-muscle
#3
Pauline Roy, Fredérique Rau, Julien Ochala, Julien Messéant, Bodvael Fraysse, Jeanne Lainé, Onnik Agbulut, Gillian Butler-Browne, Denis Furling, Arnaud Ferry
BACKGROUND: The greater susceptibility to contraction-induced skeletal muscle injury (fragility) is an important dystrophic feature and tool for testing preclinic dystrophin-based therapies for Duchenne muscular dystrophy. However, how these therapies reduce the muscle fragility is not clear. METHODS: To address this question, we first determined the event(s) of the excitation-contraction cycle which is/are altered following lengthening (eccentric) contractions in the mdx muscle...
July 20, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27906090/muscle-specific-deletion-of-socs3-increases-the-early-inflammatory-response-but-does-not-affect-regeneration-after-myotoxic-injury
#4
Kristy Swiderski, Savant S Thakur, Timur Naim, Jennifer Trieu, Annabel Chee, David I Stapleton, René Koopman, Gordon S Lynch
BACKGROUND: Muscles of old animals are injured more easily and regenerate poorly, attributed in part to increased levels of circulating pro-inflammatory cytokines. The Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling cascade is a key mediator of inflammatory cytokine action, and signaling via this pathway is increased in muscles with aging. As a negative regulator of JAK/STAT signaling, a key mediator of myogenic proliferation and differentiation, altered expression of suppressor of cytokine signaling (SOCS3) is likely to have important consequences for muscle regeneration...
October 24, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27906076/pgc-1%C3%AE-modulates-necrosis-inflammatory-response-and-fibrotic-tissue-formation-in-injured-skeletal-muscle
#5
Ivana Dinulovic, Regula Furrer, Sabrina Di Fulvio, Arnaud Ferry, Markus Beer, Christoph Handschin
BACKGROUND: Skeletal muscle tissue has an enormous regenerative capacity that is instrumental for a successful defense against muscle injury and wasting. The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) exerts therapeutic effects in several muscle pathologies, but its role in damage-induced muscle regeneration is unclear. METHODS: Using muscle-specific gain- and loss-of-function models for PGC-1α in combination with the myotoxic agent cardiotoxin (CTX), we explored the role of this transcriptional coactivator in muscle damage and inflammation...
November 8, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27906051/the-lysine-methyltransferase-ehmt2-g9a-is-dispensable-for-skeletal-muscle-development-and-regeneration
#6
Regan-Heng Zhang, Robert N Judson, David Y Liu, Jürgen Kast, Fabio M V Rossi
BACKGROUND: Euchromatic histone-lysine N-methyltransferase 2 (G9a/Ehmt2) is the main enzyme responsible for the apposition of H3K9 di-methylation on histones. Due to its dual role as an epigenetic regulator and in the regulation of non-histone proteins through direct methylation, G9a has been implicated in a number of biological processes relevant to cell fate control. Recent reports employing in vitro cell lines indicate that Ehmt2 methylates MyoD to repress its transcriptional activity and therefore its ability to induce differentiation of activated myogenic cells...
May 27, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27904629/effect-of-various-kinds-of-beverages-on-stress-oxidative-f2-isoprostane-serum-lipid-and-blood-glucose-of-elite-taekwondo-players
#7
Zahra Maghsoudi, Ashfin Shiranian, Gholamreza Askai, Reza Ghaisvand
BACKGROUND: Athletes' recovery is important in improving their performance. Nutritional strategies can be effective in enhancing recovery rate. Choosing the best food items in appropriate intervals can play effective roles in resynthesis of fuels and recovery of muscle injury. Beverage micro and macronutrient content are helpful in fuel restoration. In this study, we assess the effects of various kinds of beverages on oxidative stress, muscle injury, and metabolic risk factors in taekwondo players...
September 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27903350/-effect-of-lumbar-dorsal-muscle-injuries-on-lumbar-vertebral-bone-quality-of-rat
#8
X P Wang, S J Wang, P Yan, L L Zhu, M Q Li, Z Y Bian, J W Tian
Objective: To explored the effects of lumbar dorsal muscle damage on local lumbar vertebral bone quality. Methods: Thirty SD female rats, at age of 20 weeks, were randomly divided into three groups: control group, or say pseudo surgery group, an incision in the back were performed as CNT; bilateral erector spinal muscle group in which group bilateral lumbar erector spinal muscle were removed as RESM; castration group in which bilateral ovaries were resected as OVX.After three months, bone mineral density, microscopic CT and vertebral compression test were taken in lumbar vertebral (L4-6) in turn...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27900389/the-clearance-of-cell-remnants-and-the-regeneration-of-the-injured-muscle-depend-on-soluble-pattern-recognition-receptor-ptx3
#9
Michela Vezzoli, Clara Sciorati, Lara Campana, Antonella Monno, Maria Giulia Doglio, Elena Rigamonti, Gianfranca Corna, Thierry Touvier, Alessandra Castiglioni, Annalisa Capobianco, Alberto Mantovani, Angelo A Manfredi, Cecilia Garlanda, Patrizia Rovere-Querini
OBJECTIVE: The signals causing the resolution of muscle inflammation are only partially characterized. The long pentraxin PTX3, which modulates leukocyte recruitment and activation, could contribute. METHODS: We analysed the expression of ptx3 after muscle injury and verified whether hematopoietic precursors are a source of the protein. The kinetics of regeneration and leukocytes infiltration, the accumulation of cell remnants and anti-histidyl-t-RNA synthetase autoantibodies were compared in wild-type and ptx3-deficient mice...
November 23, 2016: Molecular Medicine
https://www.readbyqxmd.com/read/27900186/injury-incidence-in-a-premier-league-youth-soccer-academy-using-the-consensus-statement-a-prospective-cohort-study
#10
Andrew Renshaw, Peter C Goodwin
BACKGROUND: There is an established risk of injury to young athletes exposed to high training loads. Identifying and monitoring injury risk is essential to aid prevention. The aim of this study was to use the consensus statement to determine the incidence and pattern of injury in 1 English Premier League soccer academy during 1 season. METHODS: A prospective cohort study included 181 elite academy soccer players during the 2012-2013 season. Players were divided into 5 age groups between 9 and 18 years...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27895105/robot-assisted-mechanical-therapy-attenuates-stroke-induced-limb-skeletal-muscle-injury
#11
Chandan K Sen, Savita Khanna, Hallie Harris, Richard Stewart, Maria Balch, Mallory Heigel, Seth Teplitsky, Surya Gnyawali, Cameron Rink
The efficacy and optimization of poststroke physical therapy paradigms is challenged in part by a lack of objective tools available to researchers for systematic preclinical testing. This work represents a maiden effort to develop a robot-assisted mechanical therapy (RAMT) device to objectively address the significance of mechanical physiotherapy on poststroke outcomes. Wistar rats were subjected to right hemisphere middle-cerebral artery occlusion and reperfusion. After 24 h, rats were split into control (RAMT(-)) or RAMT(+) groups (30 min daily RAMT over the stroke-affected gastrocnemius) and were followed up to poststroke d 14...
November 28, 2016: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/27887768/evaluation-of-acute-kidney-injury-using-contrast-ultrasonography-in-a-rabbit-model-of-crush-syndrome
#12
Chundong Zhang, Xin Wang, Jie Tang
This study aimed to investigate the feasibility of evaluating acute kidney injury (AKI) using contrast ultrasonography in a rabbit model of crush syndrome. Sixty-four New Zealand white rabbits were anesthetized and the left hind limb was wrapped and compressed for 4 h with a sphygmomanometer. Contrast ultrasonography of the left kidney using microbubbles as the contrast medium was performed. The serum levels of blood urea nitrogen (BUN), creatine (Cr), creatine kinase (CK) and lactate dehydrogenase (LDH) were significantly increased in comparison to before the compression...
November 22, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27882212/resveratrol-and-exercise
#13
Saltuk Bugra Baltaci, Rasim Mogulkoc, Abdulkerim Kasim Baltaci
Although it is recommended for a healthy lifestyle, moderate exercise is known to lead to oxidative stress, inflammation and muscle injury. Hence there are efforts to develop dietary strategies to counter the oxidative stress caused by physical activity. Recently, there has been an interest in the capability of resveratrol (RES) to modulate physical performance and prevent oxidative stress. Despite the inconsistency among reports regarding the topic, it has been suggested that RES delays fatigue by hindering lipid peroxidation...
November 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27880908/conditional-loss-of-pten-in-myogenic-progenitors-leads-to-postnatal-skeletal-muscle-hypertrophy-but-age-dependent-exhaustion-of-satellite-cells
#14
Feng Yue, Pengpeng Bi, Chao Wang, Jie Li, Xiaoqi Liu, Shihuan Kuang
Skeletal muscle stem cells (satellite cells [SCs]) are normally maintained in a quiescent (G0) state. Muscle injury not only activates SCs locally, but also alerts SCs in distant uninjured muscles via circulating factors. The resulting GAlert SCs are adapted to regenerative cues and regenerate injured muscles more efficiently, but whether they provide any long-term benefits to SCs is unknown. Here, we report that embryonic myogenic progenitors lacking the phosphatase and tensin homolog (Pten) exhibit enhanced proliferation and differentiation, resulting in muscle hypertrophy but fewer SCs in adult muscles...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27878524/muscle-injuries-in-sports-a-new-evidence-informed-and-expert-consensus-based-classification-with-clinical-application
#15
Xavier Valle, Eduard Alentorn-Geli, Johannes L Tol, Bruce Hamilton, William E Garrett, Ricard Pruna, Lluís Til, Josep Antoni Gutierrez, Xavier Alomar, Ramón Balius, Nikos Malliaropoulos, Joan Carles Monllau, Rodney Whiteley, Erik Witvrouw, Kristian Samuelsson, Gil Rodas
Muscle injuries are among the most common injuries in sport and continue to be a major concern because of training and competition time loss, challenging decision making regarding treatment and return to sport, and a relatively high recurrence rate. An adequate classification of muscle injury is essential for a full understanding of the injury and to optimize its management and return-to-play process. The ongoing failure to establish a classification system with broad acceptance has resulted from factors such as limited clinical applicability, and the inclusion of subjective findings and ambiguous terminology...
November 23, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27875498/a-murine-model-of-robotic-training-to-evaluate-skeletal-muscle-recovery-after-injury
#16
Stefano Lai, Alessandro Panarese, Ross Lawrence, Michael L Boninger, Silvestro Micera, Fabrisia Ambrosio
PURPOSE: In vivo studies have suggested that motor exercise can improve muscle regeneration after injury. Nevertheless, pre-clinical investigations still lack reliable tools to monitor motor performance over time and to deliver optimal training protocols to maximize force recovery. Here, we evaluated the utility of a murine robotic platform to (i) detect early impairment and longitudinal recovery after acute skeletal muscle injury and (ii) administer varying intensity training protocols to enhance forelimb motor performance...
November 21, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27875415/a-posterior-oblique-approach-to-the-lumbar-disk-spaces-vertebral-bodies-and-lumbar-plexus-a-cadaveric-feasibility-study
#17
Alexander Spiessberger, Fabian Baumann, Martin Häusler, Frank Rühli, Javier Fandino, Carl Muroi
STUDY DESIGN: A laboratory cadaveric study. OBJECTIVE: We aimed to demonstrate the feasibility of a posterior oblique approach, sharing the same advantages as the transpsoas technique while minimizing the risk of lumbar plexus or psoas muscle injuries. SUMMARY OF BACKGROUND DATA: The transpsoas approach for interbody fusion and corpectomy offers advantages over posterior and anterior approaches. However, possible risks include traumatization of the psoas muscle or lumbar plexus...
November 21, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27874859/a-single-heterochronic-blood-exchange-reveals-rapid-inhibition-of-multiple-tissues-by-old-blood
#18
Justin Rebo, Melod Mehdipour, Ranveer Gathwala, Keith Causey, Yan Liu, Michael J Conboy, Irina M Conboy
Heterochronic parabiosis rejuvenates the performance of old tissue stem cells at some expense to the young, but whether this is through shared circulation or shared organs is unclear. Here we show that heterochronic blood exchange between young and old mice without sharing other organs, affects tissues within a few days, and leads to different outcomes than heterochronic parabiosis. Investigating muscle, liver and brain hippocampus, in the presence or absence of muscle injury, we find that, in many cases, the inhibitory effects of old blood are more pronounced than the benefits of young, and that peripheral tissue injury compounds the negative effects...
November 22, 2016: Nature Communications
https://www.readbyqxmd.com/read/27868064/shrimp-protein-hydrolysate-modulates-the-timing-of-proinflammatory-macrophages-in-bupivacaine-injured-skeletal-muscles-in-rats
#19
Junio Dort, Nadine Leblanc, Piotr Bryl, Marie-Gil Fortin, Marie-Elise Carbonneau, Charles Lavigne, Hélène Jacques
This study was designed to determine whether marine-derived proteins other than cod could have beneficial effects on inflammation following muscle injury. Macrophage and neutrophil densities were measured from bupivacaine-injured tibialis anterior muscle of rats fed isoenergetic diets containing either shrimp hydrolysate (Shr), casein hydrolysate (CaH), or whole casein (Ca). In this study, Shr reduced ED(1+)-macrophages at day 2 (p = 0.013), day 5 (p = 0.006), and day 14 after injury (p = 0.038) compared with Ca, indicating faster resolution of inflammation in Shr...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27862618/scleraxis-lineage-cells-contribute-to-ectopic-bone-formation-in-muscle-and-tendon
#20
Shailesh Agarwal, Shawn J Loder, David Cholok, Joshua Peterson, John Li, Christopher Breuler, R Cameron Brownley, Hsiao Hsin Sung, Mike Chung, Nobuhiro Kamiya, Shuli Li, Bin Zhao, Vesa Kaartinen, Thomas A Davis, Ammar T Qureshi, Ernestina Schipani, Yuji Mishina, Benjamin Levi
The pathologic development of heterotopic ossification (HO) is well described in patients with extensive trauma or with hyperactivating mutations of the bone morphogenetic protein (BMP) receptor ACVR1. However, identification of progenitor cells contributing to this process remains elusive. Here we show that connective tissue cells contribute to a substantial amount of HO anlagen caused by trauma using postnatal, tamoxifen-inducible, scleraxis-lineage restricted reporter mice (Scx-creERT2/tdTomato(fl/fl) )...
November 8, 2016: Stem Cells
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