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https://www.readbyqxmd.com/read/28732031/breast-tissue-ablation-with-irreversible-electroporation-in-rabbits-a-safety-and-feasibility-study
#1
Wenlong Zhang, Wanning Wang, Wei Chai, Xiaomei Luo, Jiannan Li, Jian Shi, Liqi Bi, Lizhi Niu
BACKGROUND AND AIM: Irreversible electroporation (IRE) was confirmed to control several solid tumors effectively in vivo. Our preclinical study aimed to assess the feasibility and safety of IRE in the breast of rabbit. METHODS: Thirty New Zealand white rabbits were randomly divided into 3 groups of 10 rabbits (control group, IRE group A, and B). Two mono-electrode needles were inserted into the breast tissue by percutaneous puncture. Electrocardiogram and vital signs were monitored before, during, and after ablation...
2017: PloS One
https://www.readbyqxmd.com/read/28727642/injuries-among-recreational-football-players-results-of-a-prospective-cohort-study
#2
Gürhan Dönmez, Feza Korkusuz, Levent Özçakar, Yiğitcan Karanfil, Erhan Dursun, Savaş Kudaş, Mahmut Nedim Doral
OBJECTIVES: To establish the incidence and patterns of football injuries and associated consequences in daily life and labor loss, among public employees. DESIGN: Prospective cohort study. SETTING: Football tournament between public employees in Turkey. PARTICIPANTS: A total of 1821 recreational players from 78 teams. MAIN OUTCOME MEASURES: Injury rates (injuries per 1000 hours of football exposure) during tournament by age group, as well as prevalence, severity, and injury types were recorded...
July 14, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28721121/does-the-injection-of-platelet-rich-plasma-induce-changes-in-the-gene-expression-and-morphology-of-intact-thoroughbred-skeletal-muscle
#3
Kentaro Fukuda, Hirofumi Miyata, Atsutoshi Kuwano, Taisuke Kuroda, Norihisa Tamura, Yasumitsu Kotoyori, Yoshinori Kasashima
Platelet-rich plasma (PRP) therapy is promising for treating skeletal muscle injuries in human athletes by promoting muscle regeneration. It might also be useful for treating muscle injuries in equine athletes. In the present study, muscle regeneration induced by injection of PRP into intact muscle of Thoroughbred was investigated. Autologous PRP and saline were injected twice into intact left and right gluteus medius muscles of seven clinically healthy Thoroughbreds. Muscle samples were collected from the injection sites by needle biopsy at 2 and 7 days after PRP injection...
2017: Journal of Equine Science
https://www.readbyqxmd.com/read/28716914/metabolic-profiles-of-exercise-in-patients-with-mcardle-disease-or-mitochondrial-myopathy
#4
Nigel F Delaney, Rohit Sharma, Laura Tadvalkar, Clary B Clish, Ronald G Haller, Vamsi K Mootha
McArdle disease and mitochondrial myopathy impair muscle oxidative phosphorylation (OXPHOS) by distinct mechanisms: the former by restricting oxidative substrate availability caused by blocked glycogen breakdown, the latter because of intrinsic respiratory chain defects. We applied metabolic profiling to systematically interrogate these disorders at rest, when muscle symptoms are typically minimal, and with exercise, when symptoms of premature fatigue and potential muscle injury are unmasked. At rest, patients with mitochondrial disease exhibit elevated lactate and reduced uridine; in McArdle disease purine nucleotide metabolites, including xanthine, hypoxanthine, and inosine are elevated...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28714082/in-situ-macrophage-phenotypic-transition-is-affected-by-altered-cellular-composition-prior-to-acute-sterile-muscle-injury
#5
Andreas Patsalos, Attila Pap, Tamas Varga, Gyorgy Trencsenyi, Gerardo Alvarado Contreras, Ildiko Garai, Zoltan Papp, Balazs Dezso, Eva Pintye, Laszlo Nagy
Skeletal muscle regeneration is a complex interplay between various cell types including invading macrophages. Their recruitment to damaged tissues upon acute sterile injuries is necessary for necrotic debris clearance and for coordination of tissue regeneration. This highly dynamic process is characterized by an in-situ transition of infiltrating monocytes from an inflammatory (Ly6C(high) ) to a repair (Ly6C(low) ) macrophage phenotype. The importance of the macrophage phenotypic shift and the cross-talk of the local muscle tissue with the infiltrating macrophages during tissue regeneration upon injury are not fully understood and their study lacks adequate methodology...
July 17, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28709001/ciliary-hedgehog-signaling-restricts-injury-induced-adipogenesis
#6
Daniel Kopinke, Elle C Roberson, Jeremy F Reiter
Injured skeletal muscle regenerates, but with age or in muscular dystrophies, muscle is replaced by fat. Upon injury, muscle-resident fibro/adipogenic progenitors (FAPs) proliferated and gave rise to adipocytes. These FAPs dynamically produced primary cilia, structures that transduce intercellular cues such as Hedgehog (Hh) signals. Genetically removing cilia from FAPs inhibited intramuscular adipogenesis, both after injury and in a mouse model of Duchenne muscular dystrophy. Blocking FAP ciliation also enhanced myofiber regeneration after injury and reduced myofiber size decline in the muscular dystrophy model...
July 13, 2017: Cell
https://www.readbyqxmd.com/read/28708711/contrast-enhanced-ultrasound-as-a-new-investigative-tool-in-diagnostic-imaging-of-muscle-injuries-a-pilot-study-evaluating-conventional-ultrasound-ceus-and-findings-in-mri
#7
Thilo Hotfiel, Rafael Heiss, Bernd Swoboda, Marion Kellermann, Kolja Gelse, Casper Grim, Deike Strobel, Dane Wildner
OBJECTIVE: To emphasize the diagnostic value of contrast-enhanced ultrasound (CEUS) in the imaging of muscle injuries with different degrees of severity by comparing findings to established imaging modalities such as conventional ultrasound and magnetic resonance imaging (MRI). DESIGN: Case series. SETTING: Institutional study. Conventional ultrasound and CEUS were performed in the Department of Internal Medicine. Magnetic resonance imaging was carried out in the Department of Radiology within the Magnetom Avanto 1...
July 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28706944/schisandrin-b-prevents-hind-limb-from-ischemia-reperfusion-induced-oxidative-stress-and-inflammation-via-mapk-nf-%C3%AE%C2%BAb-pathways-in-rats
#8
Ning Zhu, Changhong Cai, Aiming Zhou, Xuyong Zhao, Yijia Xiang, Chunlai Zeng
Schisandrin B (ScB), isolated from Schisandra chinensis (S. chinensis), is a traditional Chinese medicine with proven cardioprotective and neuroprotective effects. However, it is unclear whether ScB also has beneficial effects on rat hind limb ischemia/reperfusion (I/R) injury model. In this study, ScB (20 mg/kg, 40 mg/kg, and 80 mg/kg) was administered via oral gavage once daily for 5 days before the surgery. After 6 h ischemia and 24 h reperfusion of left hind limb, ScB reduced I/R induced histological changes and edema...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28704219/inflammaging-and-the-age-specific-responsiveness-to-stretch-shortening-contractions
#9
Erik P Rader, Brent A Baker
With aging, muscle injury from rapid, continuous stretch-shortening contractions (SSCs) is prolonged and maladaptation to moderate-velocity, intermittent SSCs is more common. We investigate the hypothesis that high baseline levels of inflammatory signaling and oxidative stress may underlie these outcomes, while careful modulation of high-intensity SSC training design resets basal conditions and permits muscle adaptation to SSCs.
July 12, 2017: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/28699402/the-management-of-episiotomy-technique-and-its-effect-on-pelvic-floor-muscles-during-a-malposition-childbirth
#10
Dulce A Oliveira, Marco P L Parente, Begoña Calvo, Teresa Mascarenhas, Renato M Natal Jorge
Vaginal childbirth is the leading cause of pelvic floor muscles injury, which contributes to pelvic floor dysfunction, being enhanced by fetal malposition. Therefore, the aim of the present study is to verify the influence of mediolateral episiotomies in the mechanics of the pelvic floor with the fetus in occiput posterior position when compared to the occiput anterior position. Numerical simulations of vaginal deliveries, with and without episiotomy, are performed based on the Finite Element Method. The biomechanical model includes the pelvic floor muscles, a surface to delimit the anterior region of the birth canal and a fetus...
August 2017: Computer Methods in Biomechanics and Biomedical Engineering
https://www.readbyqxmd.com/read/28698718/the-holy-grail-of-orthopedic-surgery-mesenchymal-stem-cells-their-current-uses-and-potential-applications
#11
REVIEW
Roberto Berebichez-Fridman, Ricardo Gómez-García, Julio Granados-Montiel, Enrique Berebichez-Fastlicht, Anell Olivos-Meza, Julio Granados, Cristina Velasquillo, Clemente Ibarra
Only select tissues and organs are able to spontaneously regenerate after disease or trauma, and this regenerative capacity diminishes over time. Human stem cell research explores therapeutic regenerative approaches to treat various conditions. Mesenchymal stem cells (MSCs) are derived from adult stem cells; they are multipotent and exert anti-inflammatory and immunomodulatory effects. They can differentiate into multiple cell types of the mesenchyme, for example, endothelial cells, osteoblasts, chondrocytes, fibroblasts, tenocytes, vascular smooth muscle cells, and sarcomere muscular cells...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28690008/laminin-mimetic-peptide-nanofibers-regenerate-acute-muscle-defect
#12
Cagla Eren Cimenci, Gozde Uzunalli, Ozge Uysal, Fatih Yergoz, Ebru Karaca Umay, Mustafa O Guler, Ayse B Tekinay
Skeletal muscle cells are terminally differentiated and require the activation of muscle progenitor (satellite) cells for their regeneration. There is a clinical need for faster and more efficient treatment methods for acute muscle injuries, and the stimulation of satellite cell proliferation is promising in this context. In this study, we designed and synthesized a laminin-mimetic bioactive peptide (LM/E-PA) system that is capable of accelerating satellite cell activation by emulating the structure and function of laminin, a major protein of the basal membrane of the skeletal muscle...
July 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28689354/functional-and-molecular-characterization-of-a-novel-traumatic-peripheral-nerve-muscle-injury-model
#13
Renate Wanner, Manuel Gey, Alireza Abaei, Daniela Warnecke, Luisa de Roy, Lutz Dürselen, Volker Rasche, Bernd Knöll
Traumatic injuries to human peripheral nerves are frequently associated with damage to nerve surrounding tissues including muscles and blood vessels. Currently, most rodent models of peripheral nerve injuries (e.g., facial or sciatic nerve) employ surgical nerve transection with scissors or scalpels. However, such an isolated surgical nerve injury only mildly damages neighboring tissues and weakly activates an immune response. In order to provide a rodent nerve injury model accounting for such nerve-associated tissue damage and immune cell activation, we developed a drop tower-based facial nerve trauma model in mice...
July 8, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28687543/injury-epidemiology-of-tennis-players-at-the-2011-2016-australian-open-grand-slam
#14
Danielle T Gescheit, Stuart J Cormack, Rob Duffield, Stephanie Kovalchik, Tim O Wood, Melanie Omizzolo, Machar Reid
AIM: To examine the epidemiology and in-event treatment frequency of injury at the 2011-2016 Australian Open tournaments. METHODS: Injury incidence was defined as a medical consultation by a tournament physician and in-event treatment frequency as the mean total number of follow-up medical/physiotherapy consultations (2013-2016 tournaments only). Data were collated by sex, injury region and type and reported as frequencies per 10 000 game exposures. Incidence rate s± 95% CI and rate ratios were used to test effects for injury, sex and year...
July 7, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28675098/production-of-a-novel-wheat-gluten-hydrolysate-containing-dipeptidyl-peptidase-iv-inhibitory-tripeptides-using-ginger-protease
#15
Yuki Taga, Osamu Hayashida, Masashi Kusubata, Kiyoko Ogawa-Goto, Shunji Hattori
Wheat gluten is a Pro-rich protein complex comprising glutenins and gliadins. Previous studies have reported that oral intake of enzymatic hydrolysates of gluten has beneficial effects, such as suppression of muscle injury and improvement of hepatitis. Here, we utilized ginger protease that preferentially cleaves peptide bonds with Pro at the P2 position to produce a novel type of wheat gluten hydrolysate. Ginger protease efficiently hydrolyzed gluten, particularly under weak acidic conditions, to peptides with an average molecular weight of <600 Da...
July 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28673417/neurologic-injuries-in-noncontact-sports
#16
REVIEW
Robert J Marquardt, Andrew Blake Buletko, Andrew Neil Russman
Noncontact sports are associated with a variety of neurologic injuries. Concussion, vascular injury (arterial dissection), and spinal cord trauma may be less common in noncontact sports, but require special attention from the sports neurologist. Complex regional pain disorders, muscle injury from repetitive use, dystonia, heat exposure, and vascular disorders (patent foramen ovale), occur with similar frequency in noncontact and contact sports. Management of athletes with these conditions requires an understanding of the neurologic consequences of these disorders, the risk of injury with return to play, and consideration for the benefits of exercise in health restoration and disease prevention...
August 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28671078/drug-use-to-resistance-exercise-induced-fatigue-based-on-diclofenac-diethylamine-emulgel-efficacy-analysis
#17
Qi Gu
In this paper, the author study on the effect of drug treatment on sports injury, and makes a comparative analysis of drug effects. In sports, the incidence of various types of injuries is increasing, especially in muscle injury. In the experiment, we compared the effects of three different drugs on the treatment and relief of muscle loss. After 3 weeks, the average optical density of desmin in muscle fiber positive region have decreased, as xiaotong plaster (0.4708±0.0126), votalin (0.5124±0.0264) and placebo (0...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28667588/post-injury-stretch-promotes-recovery-in-a-rat-model-of-muscle-damage-induced-by-lengthening-contractions
#18
Tomohiro Mori, Nobuhide Agata, Yuta Itoh, Masumi Inoue-Miyazu, Kazue Mizumura, Masahiro Sokabe, Toru Taguchi, Keisuke Kawakami
We investigated the cellular mechanisms and therapeutic effect of post-injury stretch on the recovery process from muscle injury induced by lengthening contractions (LC). One day after LC, a single 15-min bout of muscle stretch was applied at an intensity of 3 mNm. The maximal isometric torque was measured before and at 2-21 days after LC. The myofiber size was analyzed at 21 days after LC. Developmental myosin heavy chain-immunoreactive (dMHC-ir) cells, a marker of regenerating myofibers, were observed in the early recovery stage (2-5 days after LC)...
June 30, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28655651/cichoric-acid-improved-hyperglycaemia-and-restored-muscle-injury-via-activating-antioxidant-response-in-mld-stz-induced-diabetic-mice
#19
Di Zhu, Xinglin Zhang, Yajie Niu, Zhijun Diao, Bo Ren, Xingyu Li, Zhigang Liu, Xuebo Liu
Cichoric acid (CA), extracted from edible plants and vegetables, is a potential natural nutraceutical, with antioxidant and hypoglycaemic biological functions. The objective of this study was to explore the potential underlying molecular mechanisms involved in normalizing diabetes-related changes in hyperglycaemia via pancreas apoptosis and muscle injury induced by multiple low-dose STZ (MLD-STZ) injection in response to dietary supplementation with CA. To induce the MLD-STZ diabetic mice, the C57BL/6J mice were intraperitoneally injected with STZ (50 mg/kg body weight) for consecutive five days...
June 26, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28649793/characteristics-of-acute-groin-injuries-in-the-hip-flexor-muscles-a-detailed-mri-study-in-athletes
#20
Andreas Serner, Adam Weir, Johannes L Tol, Kristian Thorborg, Frank Roemer, Ali Guermazi, Eduardo Yamashiro, Per Hölmich
Hip flexor injuries account for one third of acute groin injuries; however, little is known about specific injury characteristics. The aims of this study was to describe acute hip flexor injuries using magnetic resonance imaging (MRI) in athletes with acute groin pain, and to compare specific muscle injuries with reported injury situations. Male athletes with acute groin pain were prospectively and consecutively included during 3 sports seasons. MRI was performed within 7 days of injury using a standardized protocol and a reliable assessment approach...
June 26, 2017: Scandinavian Journal of Medicine & Science in Sports
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