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"muscle injury"

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https://www.readbyqxmd.com/read/29234662/surgical-treatment-of-rectus-femoris-injury-in-soccer-playing-athletes-report-of-two-cases
#1
Leandro Girardi Shimba, Gabriel Carmona Latorre, Alberto de Castro Pochini, Diego Costa Astur, Carlos Vicente Andreoli
Muscle injury is the most common injury during sport practice. It represents 31% of all lesions in soccer, 16% in track and field, 10.4% in rugby, 17.7% in basketball, and between 22% and 46% in American football. The cicatrization with the formation of fibrotic tissue can compromise the muscle function, resulting in a challenging problem for orthopedics. Although conservative treatment presents adequate functional results in the majority of the athletes who have muscle injury, the consequences of treatment failure can be dramatic, possibly compromising the return to sport practice...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29233958/complement-c3a-signaling-facilitates-skeletal-muscle-regeneration-by-regulating-monocyte-function-and-trafficking
#2
Congcong Zhang, Chunxiao Wang, Yulin Li, Takashi Miwa, Chang Liu, Wei Cui, Wen-Chao Song, Jie Du
Regeneration of skeletal muscle following injury is accompanied by transient inflammation. Here we show that complement is activated in skeletal muscle injury and plays a key role during regeneration. Genetic ablation of complement C3 or its inactivation with Cobra Venom Factor (CVF) result in impaired muscle regeneration following cardiotoxin-induced injury in mice. The effect of complement in muscle regeneration is mediated by the alternative pathway and C3a receptor (C3aR) signaling, as deletion of Cfb, a key alternative pathway component, or C3aR leads to impaired regeneration and reduced monocyte/macrophage infiltration...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29225581/protective-effect-of-unacylated-ghrelin-on-compression-induced-skeletal-muscle-injury-mediated-by-sirt1-signaling
#3
Felix N Ugwu, Angus P Yu, Thomas K Sin, Bjorn T Tam, Christopher W Lai, S C Wong, Parco M Siu
Unacylated ghrelin, the predominant form of circulating ghrelin, protects myotubes from cell death, which is a known attribute of pressure ulcers. In this study, we investigated whether unacylated ghrelin protects skeletal muscle from pressure-induced deep tissue injury by abolishing necroptosis and apoptosis signaling and whether these effects were mediated by SIRT1 pathway. Fifteen adult Sprague Dawley rats were assigned to receive saline or unacylated ghrelin with or without EX527 (a SIRT1 inhibitor). Animals underwent two 6-h compression cycles with 100 mmHg static pressure applied over the mid-tibialis region of the right limb whereas the left uncompressed limb served as the intra-animal control...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29220207/mr-imaging-of-muscle-trauma-anatomy-biomechanics-pathophysiology-and-imaging-appearance
#4
Dyan V Flores, Catalina Mejía Gómez, Mauricio Estrada-Castrillón, Edward Smitaman, Mini N Pathria
Muscle is an important component of the muscle-tendon-bone unit, driving skeletal motion through contractions that alter the length of the muscle. The muscle and myotendinous junction (MTJ) are most commonly injured in the young adult, as a result of indirect mechanisms such as overuse or stretching, direct impact (penetrating or nonpenetrating), or dysfunction of the supporting connective tissues. Magnetic resonance (MR) imaging is widely used for assessment of muscle injuries. This review illustrates the MR imaging appearance of a broad spectrum of acute, subacute, and chronic traumatic lesions of muscle, highlighting the pathophysiology, biomechanics, and anatomic considerations underlying these lesions...
December 8, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29217532/imaging-detected-acute-muscle-injuries-in-athletes-participating-in-the-rio-de-janeiro-2016-summer-olympic-games
#5
Michel D Crema, Mohamed Jarraya, Lars Engebretsen, Frank W Roemer, Daichi Hayashi, Romulo Domingues, Abdalla Y Skaf, Ali Guermazi
BACKGROUND: Acute muscle injuries in elite athletes are responsible for a large portion of time loss injuries. AIM: To describe the frequency, the anatomic distribution, and severity of imaging-detected acute muscle injuries among athletes who competed in the Rio de Janeiro 2016 Summer Olympics. METHODS: We recorded all sports injuries reported by the National Olympic Committee medical teams and the Organising Committee medical staff during the 2016 Summer Olympics...
December 7, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29216241/discussion-about-different-cut-off-values-of-conventional-hamstring-to-quadriceps-ratio-used-in-hamstring-injury-prediction-among-professional-male-football-players
#6
Monika Grygorowicz, Martyna Michałowska, Tomasz Walczak, Adam Owen, Jakub Krzysztof Grabski, Andrzej Pyda, Tomasz Piontek, Tomasz Kotwicki
OBJECTIVE: To measure the sensitivity and specificity of differences cut-off values for isokinetic Hcon/Qcon ratio in order to improve the capacity to evaluate (retrospectively) the injury of hamstring muscles in professional soccer screened with knee isokinetic tests. DESIGN: Retrospective study. METHODS: Medical and biomechanical data of professional football players playing for the same team for at least one season between 2010 and 2016 were analysed...
2017: PloS One
https://www.readbyqxmd.com/read/29187245/d-%C3%AE-hydroxybutyrate-and-melatonin-for-treatment-of-porcine-hemorrhagic-shock-and-injury-a-melatonin-dose-ranging-study
#7
Andrea Wolf, Kristine E Mulier, Sydne L Muratore, Gregory J Beilman
OBJECTIVE: Treatment with a combination of D-β-hydroxybutyrate (BHB) and melatonin (M) improves survival in hemorrhagic shock models. Our objective was to find the most effective melatonin concentration in combination with 4 molar BHB (4 M BHB). Survival and markers of organ injury were analyzed in pigs exposed to pulmonary contusion, liver crush injury, and hemorrhagic shock and treated with lactated Ringer's solution; 4 M BHB/43 mM M; 4 M BHB/20 mM M; 4 M BHB/10 mM M; 4 M BHB/4...
November 29, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29169990/lack-of-heme-oxygenase-1-induces-inflammatory-reaction-and-proliferation-of-muscle-satellite-cells-after-cardiotoxin-induced-skeletal-muscle-injury
#8
Magdalena Kozakowska, Katarzyna Pietraszek-Gremplewicz, Maciej Ciesla, Marta Seczynska, Iwona Bronisz-Budzynska, Paulina Podkalicka, Karolina Bukowska-Strakova, Agnieszka Loboda, Alicja Jozkowicz, Jozef Dulak
Heme oxygenase-1 (HO-1, Hmox1) regulates viability, proliferation, and differentiation of many cell types, hence it may affect regeneration of injured skeletal muscle. Here we injected cardiotoxin into gastrocnemius muscle of Hmox1+/+ and Hmox1-/- animals and analyzed cellular response after muscle injury, focusing on muscle satellite cells (SC), inflammatory reaction, fibrosis, and formation of new blood vessels. HO-1 is strongly induced after muscle injury, being expressed mostly in the infiltrating leukocytes (CD45+ cells), including macrophages (F4/80+ cells)...
November 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29162011/skeletal-muscle-injury-biomarkers-assay-qualification-efforts-and-translation-to-the-clinic
#9
Richard A Goldstein
Skeletal muscle (SKM) injury or myopathy results in structural or functional defects in SKMs that can be caused by variety of factors such as (1) genetic, (2) drug-induced, (3) disease progression (cachexia), or (4) aging (sarcopenia). Creatine kinase (CK) and aspartate transaminase (AST) activity assays have been routinely used as SKM injury biomarkers, but they lack sensitivity and tissue specificity. In collaboration with the Predictive Safety Testing Consortium, we evaluated the diagnostic performance of a muscle injury biomarker panel (MIP) compared to CK and AST and their correlation with the histology scores across 34 different rat studies...
October 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/29155622/imaging-of-muscle-injuries-in-sports-medicine-sports-imaging-series
#10
Ali Guermazi, Frank W Roemer, Philip Robinson, Johannes L Tol, Ravindar R Regatte, Michel D Crema
No abstract text is available yet for this article.
December 2017: Radiology
https://www.readbyqxmd.com/read/29155618/classification-of-muscle-injuries-a-misunderstanding
#11
Gülgün Atilla
No abstract text is available yet for this article.
December 2017: Radiology
https://www.readbyqxmd.com/read/29152896/trimetazidine-restores-the-positive-adaptation-to-exercise-training-by-mitigating-statin-induced-skeletal-muscle-injury
#12
Ming Song, Fang-Fang Chen, Yi-Hui Li, Lei Zhang, Feng Wang, Ran-Ran Qin, Zhi-Hao Wang, Ming Zhong, Meng-Xiong Tang, Wei Zhang, Lu Han
BACKGROUND: Exercise rehabilitation is demonstrated to improve the prognosis of patients with coronary heart disease (CHD). Statins, as the key medicine to lower cholesterol in CHD, result in skeletal muscle injury and impair exercise training adaptation. Energy metabolism dysfunction is identified as the potential mechanism underlying statin-induced skeletal muscle injury. In this study, we investigated the effects of the metabolic modulator trimetazidine on skeletal muscle energy metabolism and statin-associated exercise intolerance...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29146735/reduced-dnmt3a-increases-gdf5-expression-with-suppressed-satellite-cell-differentiation-and-impaired-skeletal-muscle-regeneration
#13
Yukino Hatazawa, Yusuke Ono, Yuma Hirose, Sayaka Kanai, Nobuharu L Fujii, Shuichi Machida, Ichizo Nishino, Takahiko Shimizu, Masaki Okano, Yasutomi Kamei, Yoshihiro Ogawa
DNA methylation is an epigenetic mechanism regulating gene expression. In this study, we observed that DNA methyltransferase 3a (Dnmt3a) expression is decreased after muscle atrophy. We made skeletal muscle-specific Dnmt3a knockout mice (Dnmt3a-KO mice). The regeneration capacity after muscle injury was markedly decreased in Dnmt3a-KO mice. Diminished mRNA and protein expression of Dnmt3a were observed in skeletal muscles as well as in satellite cells, which are important for muscle regeneration, in Dnmt3a-KO mice...
November 16, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29135647/the-role-of-platelet-rich-plasma-in-muscle-healing
#14
Paolo Borrione, Federica Fagnani, Alessia Di Gianfrancesco, Annamaria Mancini, Fabio Pigozzi, Yannis Pitsiladis
The healing of a muscle injury is a complex and dynamic process characterized by different overlapping phases resulting in the restoration of the anatomic continuity and function. This process, triggered by the tissue injury itself, is modulated by different growth factors capable of directing the recruitment, duplication, activation, and differentiation of different cell types. This key role played by different growth factors is the basis of the use of platelet-rich plasma in several circumstances, all of them characterized by the need of activating or ameliorating the process of tissue repair...
November 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/29134575/impact-of-intramuscular-administration-of-lipid-soluble-and-water-soluble-vehicles-into-regenerating-muscle-at-the-distinct-phases-of-skeletal-muscle-regeneration
#15
Ratchakrit Srikuea, Kanokwan Suhatcho
Interpretation on the effectiveness of potential substances to enhance skeletal muscle regeneration is difficult if an inappropriate vehicle is administered, since vehicle administration can directly enhance or suppress regenerative capacity. In the current study, intramuscular administration of lipid-soluble and water-soluble vehicles into regenerating muscle at the distinct phases of skeletal muscle regeneration (regenerative vs. remodeling) were investigated. Tested vehicles included lipid-soluble [olive oil, (0...
November 13, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29126754/effect-of-pulsed-therapeutic-ultrasound-and-diosmin-on-skeletal-muscle-oxidative-parameters
#16
Luis Fernando Sousa Filho, Paula P Menezes, Dayanne Valéria Soares Santana, Bruno S Lima, Shanmugan Saravanan, Grace Kelly M Almeida, José Evaldo R Menezes Filho, Marta M B Santos, Adriano Antunes A S Araújo, Evaleide Diniz de Oliveira
Cyclodextrins (CDs) have been widely used as a promising alternative in the formation of inclusion complexes with poorly soluble molecules. From this perspective, the present study aimed to study the inclusion complexes of diosmin in β-cyclodextrin, chemically quantify the diosmin-in-gel preparation and analyze the stability of the gels. Furthermore, we evaluated the effect of therapeutic pulsed ultrasound (TPU) in association with the gel-diosmin complex on the parameters of muscle damage and oxidative stress in rats...
November 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29124664/downhill-exercise-alters-immunoproteasome-content-in-mouse-skeletal-muscle
#17
Cory W Baumann, Dongmin Kwak, Deborah A Ferrington, LaDora V Thompson
Content of the immunoproteasome, the inducible form of the standard proteasome, increases in atrophic muscle suggesting it may be associated with skeletal muscle remodeling. However, it remains unknown if the immunoproteasome responds to stressful situations that do not promote large perturbations in skeletal muscle proteolysis. The purpose of this study was to determine how an acute bout of muscular stress influences immunoproteasome content. To accomplish this, wild-type (WT) and immunoproteasome knockout lmp7 (-/-) /mecl1 (-/-) (L7M1) mice were run downhill on a motorized treadmill...
November 9, 2017: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29115986/the-breaking-and-making-of-healthy-adult-human-skeletal-muscle-in-vivo
#18
Abigail L Mackey, Michael Kjaer
BACKGROUND: While muscle regeneration has been extensively studied in animal and cell culture models, in vivo myogenesis in adult human skeletal muscle has not been investigated in detail. METHODS: Using forced lengthening contractions induced by electrical stimulation, we induced myofibre injury in young healthy males. Muscle biopsies were collected from the injured leg 7 and 30 days after muscle injury and from the uninjured leg as a control. Immuno-stained single muscle fibres and muscle cross sections were studied by wide-field and confocal microscopy...
November 7, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/29101101/muscle-injury-rate-in-professional-football-is-higher-in-matches-played-within-5-days-since-the-previous-match-a-14-year-prospective-study-with-more-than-130-000-match-observations
#19
Håkan Bengtsson, Jan Ekstrand, Markus Waldén, Martin Hägglund
BACKGROUND: The association between match congestion and injury rates in professional football has yielded conflicting results. AIM: To analyse associations between match congestion on an individual player level and injury rates during professional football matches. METHODS: Data from a prospective cohort study of professional football with 133 170 match observations were analysed with Poisson regressions. Associations between short-term match congestion, defined as number of days between two match exposures (≤3, 4, 5, 6 and 7-10 days) and injury rates were analysed...
November 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29095275/muscle-ultrasound-a-useful-tool-in-newborn-screening-for-infantile-onset-pompe-disease
#20
Hsuen-En Hwang, Ting-Rong Hsu, Yueh-Hui Lee, Hsin-Kai Wang, Hong-Jen Chiou, Dau-Ming Niu
Our study aimed to evaluate the utility of muscle ultrasound in newborn screening of infantile-onset Pompe disease (IOPD) and to establish a system of severity grading. We retrospectively selected 35 patients with initial low acid alpha-glucosidase (GAA) activity and collected data including muscle ultrasound features, GAA gene mutation, activity/performance, and pathological and laboratory findings. The echogenicity of 6 muscles (the bilateral vastus intermedius, rectus femoris, and sartorius muscles) was compared to that of epimysium on ultrasound and rated either 1 (normal), 2 (mildly increased), or 3 (obviously increased)...
November 2017: Medicine (Baltimore)
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