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"muscle injury"

Carlos A Aguilar, Ramona Pop, Anna Shcherbina, Alain Watts, Ronald W Matheny, Davide Cacchiarelli, Woojin M Han, Eunjung Shin, Shadi A Nakhai, Young C Jang, Christopher T Carrigan, Casey A Gifford, Melissa A Kottke, Marcella Cesana, Jackson Lee, Maria L Urso, Alexander Meissner
Following injury, adult skeletal muscle undergoes a well-coordinated sequence of molecular and physiological events to promote repair and regeneration. However, a thorough understanding of the in vivo epigenomic and transcriptional mechanisms that control these reparative events is lacking. To address this, we monitored the in vivo dynamics of three histone modifications and coding and noncoding RNA expression throughout the regenerative process in a mouse model of traumatic muscle injury. We first illustrate how both coding and noncoding RNAs in tissues and sorted satellite cells are modified and regulated during various stages after trauma...
October 20, 2016: Stem Cell Reports
Gamze Cebi, Şenol Yildiz, Gunalp Uzun, Yeşim Oztas, Suna Sabuncuoglu, Ayhan Kutlu, Yasin Ilgaz, Iclal Karatop-Cesur, Eyup Dogan, Emin Oztas
Myoglobinuric acute renal failure (MARF) may develop after severe muscle injury. Heme oxygenase-1 (HO-1), a stress-response protein, has been implicated as a protective agent against MARF. We hypothesized that hyperbaric oxygen therapy (HBOT) may alleviate MARF by inducing renal HO-1 expression. Wistar-Albino rats were randomly assigned into three groups: Control (n = 4), MARF (n = 8), MARF + HBO (n = 8). MARF was induced by intramuscular glycerol (50%, 8 mL/kg) injection. Saline (8 mL/kg) was injected into the hind limb of the animals in the control group...
October 20, 2016: Renal Failure
Jerôme Montfort, Aurelie Le Cam, Jean-Charles Gabillard, Pierre-Yves Rescan
BACKGROUND: Muscle fibre hyperplasia stops in most fish when they reach approximately 50 % of their maximum body length. However, new small-diameter muscle fibres can be produced de novo in aged fish after muscle injury. Given that virtually nothing is known regarding the transcriptional mechanisms that regulate regenerative myogenesis in adult fish, we explored the temporal changes in gene expression during trout muscle regeneration following mechanical crushing. Then, we compared the gene transcription profiles of regenerating muscle with the previously reported gene expression signature associated with muscle fibre hyperplasia...
October 18, 2016: BMC Genomics
Angelina Freitas Siqueira, Amilton Vieira, Gracielle Vieira Ramos, Rita de Cássia Marqueti, Tania de Fátima Salvini, Gustavo Orione Puntel, Joao Luiz Quagliotti Durigan
OBJECTIVES: To investigate the effects of multiple cryotherapy applications after muscle injury on markers of oxidative stress. METHODS: Following cryolesion-induced skeletal muscle injury in rats, ice was applied at the injured site for 30 minutes, three times per day, on the day of injury, and for 2 days after injury. To determine the effect of the cryotherapy treatment on markers of oxidative stress, biochemical analyses were performed 3, 7, and 14 days after injury...
October 18, 2016: Redox Report: Communications in Free Radical Research
Ling Xin, Li Qian Jun, Xu Li Hua, Zhu Hong, Chen Tian Bao, Tang Jin Hai
BACKGROUND/AIMS: Complications are important determining factors for safety of endoscopic submucosal dissection (ESD) for gastric heterotopic pancreas (HP). This study investigated whether endoscopic color Doppler ultrasonography (ECDUS) could be used to predict the feasibility, efficacy, and safety of ESD. PATIENTS AND METHODS: The study included 52 patients with heterotopic pancreas of the gastric antrum who underwent ECDUS before ESD. ECDUS was used to evaluate the submucosal vascular structure and the location of HP in gastric wall...
September 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
Kamil Kowalski, Aleksandra Kołodziejczyk, Maria Helena Sikorska, Jagoda Płaczkiewicz, Paulina Cichosz, Magdalena Kowalewska, Wladyslawa Streminska, Katarzyna Janczyk-Ilach, Marta Koblowska, Anna Fogtman, Roksana Iwanicka-Nowicka, Maria A Ciemerych, Edyta Brzoska
The skeletal muscle regeneration occurs due to the presence of tissue specific stem cells - satellite cells. These cells, localized between sarcolemma and basal lamina, are bound to muscle fibers and remain quiescent until their activation upon muscle injury. Due to pathological conditions, such as extensive injury or dystrophy, skeletal muscle regeneration is diminished. Among the therapies aiming to ameliorate skeletal muscle diseases are transplantations of the stem cells. In our previous studies we showed that Sdf-1 (stromal derived factor -1) increased migration of stem cells and their fusion with myoblasts in vitro...
October 13, 2016: Cell Adhesion & Migration
Angela Zissler, Peter Steinbacher, Reinhold Zimmermann, Stefan Pittner, Walter Stoiber, Arne C Bathke, Alexandra M Sänger
BACKGROUND: Muscle injuries are among the most common sports-related lesions in athletes; however, optimal treatment remains obscure. Extracorporeal shock wave therapy (ESWT) may be a promising approach in this context, because it has gained increasing importance in tissue regeneration in various medical fields. HYPOTHESIS: ESWT stimulates and accelerates regenerative processes of acute muscle injuries. STUDY DESIGN: Controlled laboratory study...
October 11, 2016: American Journal of Sports Medicine
Tarek M Hegazi, Jeffrey A Belair, Eoghan J McCarthy, Johannes B Roedl, William B Morrison
Injuries of the hip and surrounding structures represent a complex and commonly encountered scenario in athletes, with improper diagnosis serving as a cause of delayed return to play or progression to a more serious injury. As such, radiologists play an essential role in guiding management of athletic injuries. Familiarity with hip anatomy and the advantages and limitations of various imaging modalities is of paramount importance for accurate and timely diagnosis. Magnetic resonance (MR) imaging is often the modality of choice for evaluating many of the injuries discussed, although preliminary evaluation with conventional radiography and use of other imaging modalities such as ultrasonography (US), computed tomography, and bone scintigraphy may be supplementary or preferred in certain situations...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Tina T Thomas, Daniel H Teitelbaum, Ethan A Smith, Jonathan R Dillman, Ranjith Vellody, Marcus D Jarboe
PURPOSE: Surgical procedures for high imperforate anus have ranged from the posterior sagittal anorectoplasty (PSARP) to laparoscopic-assisted anorectoplasty (LAARP). PSARP bisects the sphincter muscle complex, introducing muscle injury and scarring. LAARP uses a straight trocar to traverse an often non-linear sphincter muscle complex. MRI-assisted LAARP (MRI-LAARP) guides the neorectum precisely through the middle of the entire sphincter complex along its trajectory. We present our experience utilizing MRI intraoperatively during LAARP...
October 8, 2016: Pediatric Surgery International
Kyle S Martin, Christopher D Kegelman, Kelley M Virgilio, Julianna A Passipieri, George J Christ, Silvia S Blemker, Shayn M Peirce
Numerous studies have pharmacologically modulated the muscle milieu in the hopes of promoting muscle regeneration; however, the timing and duration of these interventions are difficult to determine. This study utilized a combination of in silico and in vivo experiments to investigate how inflammation manipulation improves muscle recovery following injury. First, we measured macrophage populations following laceration injury in the rat tibialis anterior (TA). Then we calibrated an agent-based model (ABM) of muscle injury to mimic the observed inflammation profiles...
October 7, 2016: Annals of Biomedical Engineering
Mohamed A A Mahdy, Katsuhiko Warita, Yoshinao Z Hosaka
In this study, we investigated the early changes of skeletal muscle damage in response to injuries induced by cardiotoxin (CTX) and glycerol by using both light microscopy and transmission electron microscopy. Normal, non-dystrophic, adult male mice were used in this study. Tibialis anterior (TA) muscles were injected either with CTX or glycerol. Samples were collected at intervals starting from 1h up to 4days after injury. Injured muscles were subjected to both histological and ultrastructural analyses. CTX-induced injury caused mitochondrial accumulation and swelling followed by lysis, while glycerol-induced injury caused accumulation of vesicles with focal disruption of the basal lamina, indicating that the injuries have different mechanisms of damage to myofibers...
September 28, 2016: Micron: the International Research and Review Journal for Microscopy
Amir Mizbani, Edlira Luca, Elisabeth J Rushing, Jan Krützfeldt
MicroRNAs (miRNAs) are important regulators of skeletal muscle regeneration, but the underlying mechanisms are still incompletely understood. Here, comparative miRNA sequencing analysis of myogenic progenitor cells (MPs) and non-myogenic fibroblast-adipocyte progenitors (FAPs) during cardiotoxin (CTX)-induced muscle injury uncovered miR-501 as a novel muscle-specific miRNA. miR-501 is an intronic miRNA and its expression levels in MPs correlated with its host gene, chloride channel, voltage-sensitive 5, Clcn5 Pharmacological inhibition of miR-501 dramatically blunted the induction of embryonic myosin heavy chain (MYH3) and, to a lesser extent, adult myosin isoforms during muscle regeneration and promoted small-diameter neofibers...
October 5, 2016: Development
W Wu
The effects of muscle-specific miRNAs in the repair of exercise-induced muscle injury were investigated by examining the changes in their expression and that of the target genes in rat skeletal muscle. Two-month-old agile male rats were randomly divided into exercise and static control groups, the former subdivided into 0-h, 6-h, 12-h, 1-day, 2-day, 3-day, 1-week, and 2-week groups based on time after exercise. Left gastrocnemii of rats were hematoxylin-eosin stained whereas the right gastrocnemii were used for expression analysis of muscle-specific miRNAs (miR-1 and miR-206) and their target genes, Cx43 and HDAC...
September 16, 2016: Genetics and Molecular Research: GMR
Man-Kyo Chung, Jennifer Park, Jamila Asgar, Jin Y Ro
BACKGROUND: Chronic pain in masticatory muscles is a major medical problem. Although mechanisms underlying persistent pain in masticatory muscles are not fully understood, sensitization of nociceptive primary afferents following muscle inflammation or injury contributes to muscle hyperalgesia. It is well known that craniofacial muscle injury or inflammation induces regulation of multiple genes in trigeminal ganglia, which is associated with muscle hyperalgesia. However, overall transcriptional profiles within trigeminal ganglia following masseter inflammation have not yet been determined...
2016: Molecular Pain
Kelsey A Thomas, Michael C Gibbons, John G Lane, Anshuman Singh, Samuel R Ward, Adam J Engler
Full thickness rotator cuff tendon (RCT) tears have long-term effects on RC muscle atrophy and fatty infiltration, with lasting damage even after surgical tendon repair. Skeletal muscle progenitor cells (SMPs) are critical for muscle repair in response to injury, but the inability of RC muscles to recover from chronic RCT tear indicates possible deficits in repair mechanisms. Here we investigated if muscle injury state was a crucial factor during human SMP expansion and differentiation ex vivo. SMPs were isolated from muscles in patients with no, partial-thickness (PT), or full-thickness (FT) RCT tears...
October 4, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Christian Haser, Thomas Stöggl, Monika Kriner, Jörg Mikoleit, Bernd Wolfahrt, Johannes Scherr, Martin Halle, Florian Pfab
PURPOSE: Increase in muscle force, endurance and flexibility is desired in elite athletes in order to improve performance and avoid injuries but often hindered by occurence of myofascial trigger points. Dry needling (DN) has been shown effective in eliminating myofascial trigger points. METHODS: This randomized controlled study in 30 elite youth soccer players of a professional soccer Bundesliga Club investigated the effects of four weekly sessions of DN plus water-pressure-massage on thigh muscle force and range-of-motion of hip flexion...
September 28, 2016: Medicine and Science in Sports and Exercise
Pascal Edouard, Pedro Branco, Juan-Manuel Alonso
OBJECTIVE: The purpose of this study was to analyse the incidence and characteristics of muscle injuries and hamstring muscle injuries occurred during the international athletics championships from 2007 to 2015. PATIENTS AND METHODS: National medical teams and local organizing committee physicians have collected every day all newly occurred injury whenever international championship from 2007 to 2015. Only the muscle injuries and hamstring muscle injuries, whatever gravity (cramp, contracture, rupture, avulsion), were analysed...
September 2016: Annals of Physical and Rehabilitation Medicine
Pascal Edouard, Jean-Michel Serra, Pierre Hertert, Emmanuelle Cugy, Nicolas Morel, Martine Prevost, Frédéric Depiesse
OBJECTIVE: The epidemiology of injuries is the first step in the sports injuries prevention. In this context, the IAAF and EA have implemented a prospective injury follow-up during their international athletics championships since 2007, and the FFA initiated since the French championships in 2014. The aim of the study was to determine the incidence and characteristics of injuries during the French Elite championships. PATIENTS AND METHODS: During the period of the outdoor and indoor French Elite championships, all newly occurring injuries were recorded by the local medical team...
September 2016: Annals of Physical and Rehabilitation Medicine
Pascal Edouard, Emmanuelle Cugy, Romain Dolin, Nicolas Morel, Kathrin Steffen
OBJECTIVE: The incidence of injuries in athletics is important, with consequences at short and long terms in sport, health, social and professional levels. It is therefore important to define strategies to reduce the incidence and severity of injuries in athletics. The objective of this study was to determine whether an injury prevention program (IPP) can reduce the occurrence and/or severity of injuries related to the practice of athletics. MATERIAL AND METHODS: The IPP has been developed, based on current scientific knowledge, targeting exercises on the most common injuries in athletics (hamstring muscle injury, Achilles and patellar tendinopathy, low back pain, ankle sprain) and selecting exercises known to treat and/or prevent these injuries (care stability, hamstrings and leg eccentric muscle strengthening, pelvis balance and stabilizing work)...
September 2016: Annals of Physical and Rehabilitation Medicine
Pascal Edouard, Pierre Samozino, Romain Slotala, Jurdan Mendiguchia, Jean-Benoit Morin
Hamstring muscle injury is the main injury related to athletics, but also other sports including acceleration and sprints, with important consequences (time loss of sport and re-injury risk). In a prevention approach, a better knowledge of risk factors and mechanisms of these lesions seem relevant, and it can pass through a better understanding of the biomechanical and muscular determinants of performance in sprint and acceleration. The ability to produce a horizontal force on the ground [i.e. orienting the total push backward (or ground force reaction forward)], and to do so despite the increase in running speed, is an important determinant of sprint performance...
September 2016: Annals of Physical and Rehabilitation Medicine
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