Barbara Barylko, Clinton A Taylor, Jason Wang, Svetlana Earnest, Steve Stippec, Derk D Binns, Chad A Brautigam, David M Jameson, George N DeMartino, Melanie H Cobb, Joseph P Albanesi
Activity-regulated cytoskeleton-associated protein (Arc) plays essential roles in diverse forms of synaptic plasticity, including long-term potentiation (LTP), long-term depression (LTD), and homeostatic plasticity. In addition, it assembles into virus-like particles that may deliver mRNAs and/or other cargo between neurons and neighboring cells. Considering this broad range of activities, it is not surprising that Arc is subject to regulation by multiple types of post-translational modification, including phosphorylation, palmitoylation, SUMOylation, ubiquitylation, and acetylation...
January 8, 2024: International Journal of Molecular Sciences