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Homeostatic plasticity

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https://www.readbyqxmd.com/read/28431369/the-temporal-paradox-of-hebbian-learning-and-homeostatic-plasticity
#1
REVIEW
Friedemann Zenke, Wulfram Gerstner, Surya Ganguli
Hebbian plasticity, a synaptic mechanism which detects and amplifies co-activity between neurons, is considered a key ingredient underlying learning and memory in the brain. However, Hebbian plasticity alone is unstable, leading to runaway neuronal activity, and therefore requires stabilization by additional compensatory processes. Traditionally, a diversity of homeostatic plasticity phenomena found in neural circuits is thought to play this role. However, recent modelling work suggests that the slow evolution of homeostatic plasticity, as observed in experiments, is insufficient to prevent instabilities originating from Hebbian plasticity...
April 18, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28418333/nonlinear-feedback-drives-homeostatic-plasticity-in-h2o2-stress-response
#2
Youlian Goulev, Sandrine Morlot, Audrey Matifas, Bo Huang, Mikael Molin, Michel B Toledano, Gilles Charvin
Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell's ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such adaptive homeostasis remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled H2O2 stress patterns...
April 18, 2017: ELife
https://www.readbyqxmd.com/read/28407141/sensory-deprivation-triggers-synaptic-and-intrinsic-plasticity-in-the-hippocampus
#3
Hila Milshtein-Parush, Samuel Frere, Limor Regev, Coren Lahav, Amit Benbenishty, Shamgar Ben-Eliyahu, Inbal Goshen, Inna Slutsky
Hippocampus, a temporal lobe structure involved in learning and memory, receives information from all sensory modalities. Despite extensive research on the role of sensory experience in cortical map plasticity, little is known about whether and how sensory experience regulates functioning of the hippocampal circuits. Here, we show that 9 ± 2 days of whisker deprivation during early mouse development depresses activity of CA3 pyramidal neurons by several principal mechanisms: decrease in release probability, increase in the fraction of silent synapses, and reduction in intrinsic excitability...
April 12, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28400058/the-snk-and-spar-signaling-pathway-changes-in-hippocampal-neurons-treated-with-amyloid-beta-peptide-in-vitro
#4
Hua Sui, Libin Zhan, Xinping Niu, Lina Liang, Xin Li
Amyloid-β peptide (Aβ) is believed to be a primary cause of Alzheimer's disease. Many studies have demonstrated that Aβ causes morphological and functional alterations of dendritic spines, leading to synaptic dysfunction, but the effect of Aβ on damage to synaptic functions is not fully understood. Spine-associated Rap guanosine triphosphatase-activating protein (SPAR) is an important regulator of activity-dependent remodeling of synapses and is critically involved in both mature dendritic spine formation and the maintenance of spine maturity...
March 22, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28391010/monocular-deprivation-of-fourier-phase-information-boosts-the-deprived-eye-s-dominance-during-interocular-competition-but-not-interocular-phase-combination
#5
Jianying Bai, Xue Dong, Sheng He, Min Bao
Ocular dominance has been extensively studied, often with the goal to understand neuroplasticity, which is a key characteristic within the critical period. Recent work on monocular deprivation, however, demonstrates residual neuroplasticity in the adult visual cortex. After deprivation of patterned inputs by monocular patching, the patched eye becomes more dominant. Since patching blocks both the Fourier amplitude and phase information of the input image, it remains unclear whether deprivation of the Fourier phase information alone is able to reshape eye dominance...
April 5, 2017: Neuroscience
https://www.readbyqxmd.com/read/28389697/antioxidant-capacity-lipid-peroxidation-and-lipid-composition-changes-during-long-term-and-short-term-thermal-acclimation-in-daphnia
#6
Bret L Coggins, John W Collins, Kailea J Holbrook, Lev Y Yampolsky
Examples of phenotypic plasticity-the ability of organisms of identical genotypes to produce different phenotypes in response to the environment-are abundant, but often lack data on the causative physiology and biochemistry. Phenotypes associated with increased protection against or reduced damage from harmful environments may, in fact, be downstream effects of hidden adaptive responses that remain elusive to experimental measurement or be obscured by homeostatic or over-compensatory effects. The freshwater zooplankton crustacean Daphnia drastically increases its heat tolerance as the result of acclimation to high temperatures, an effect often assumed to be based on plastic responses allowing better protection against oxidative stress...
April 7, 2017: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/28343184/regulatory-role-of-ngfs-in-neurocognitive-functions
#7
Ashutosh Kumar, Vikas Pareek, Muneeb A Faiq, Pavan Kumar, Khursheed Raza, Pranav Prasoon, Subrahamanyam Dantham, Sankat Mochan
Nerve growth factors (NGFs), especially the prototype NGF and brain-derived neurotrophic factor (BDNF), have a diverse array of functions in the central nervous system through their peculiar set of receptors and intricate signaling. They are implicated not only in the development of the nervous system but also in regulation of neurocognitive functions like learning, memory, synaptic transmission, and plasticity. Evidence even suggests their role in continued neurogenesis and experience-dependent neural network remodeling in adult brain...
March 27, 2017: Reviews in the Neurosciences
https://www.readbyqxmd.com/read/28334879/altered-sleep-homeostasis-correlates-with-cognitive-impairment-in-patients-with-focal-epilepsy
#8
Melanie Boly, Benjamin Jones, Graham Findlay, Erin Plumley, Armand Mensen, Bruce Hermann, Guilio Tononi, Rama Maganti
In animal studies, both seizures and interictal spikes induce synaptic potentiation. Recent evidence suggests that electroencephalogram slow wave activity during sleep reflects synaptic potentiation during wake, and that its homeostatic decrease during the night is associated with synaptic renormalization and its beneficial effects. Here we asked whether epileptic activity induces plastic changes that can be revealed by high-density electroencephalography recordings during sleep in 15 patients with focal epilepsy and 15 control subjects...
April 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334601/a-tale-of-two-inputs
#9
James Ashley, Vivian Budnik
In this issue of Neuron, Newman et al. (2017) image calcium events at single synapses of unanesthetized Drosophila larvae. Synaptic plasticity and homeostatic regulation of synapses is established to be input specific. Furthermore, plasticity forms involve selective recruitment of previously active or silent synapses.
March 22, 2017: Neuron
https://www.readbyqxmd.com/read/28325212/chemokine-receptor-signaling-and-the-hallmarks-of-cancer
#10
R A Lacalle, R Blanco, L Carmona-Rodríguez, A Martín-Leal, E Mira, S Mañes
The chemokines are a family of chemotactic cytokines that mediate their activity by acting on seven-transmembrane-spanning G protein-coupled receptors. Both the ability of the chemokines and their receptors to form homo- and heterodimers and the promiscuity of the chemokine-chemokine receptor interaction endow this protein family with enormous signaling plasticity and complexity that are not fully understood at present. Chemokines were initially identified as essential regulators of homeostatic and inflammatory trafficking of innate and adaptive leucocytes from lymphoid organs to tissues...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28323619/fast-spiking-gaba-circuit-dynamics-in-the-auditory-cortex-predict-recovery-of-sensory-processing-following-peripheral-nerve-damage
#11
Jennifer Resnik, Daniel B Polley
Cortical neurons remap their receptive fields and rescale sensitivity to spared peripheral inputs following sensory nerve damage. To address how these plasticity processes are coordinated over the course of functional recovery, we tracked receptive field reorganization, spontaneous activity, and response gain from individual principal neurons in the adult mouse auditory cortex over a 50-day period surrounding either moderate or massive auditory nerve damage. We related the day-by-day recovery of sound processing to dynamic changes in the strength of intracortical inhibition from parvalbumin-expressing (PV) inhibitory neurons...
March 21, 2017: ELife
https://www.readbyqxmd.com/read/28320737/mir-31-mutants-reveal-continuous-glial-homeostasis-in-the-adult-drosophila-brain
#12
Lynette Caizhen Foo, Shilin Song, Stephen Michael Cohen
The study of adult neural cell production has concentrated on neurogenesis. The mechanisms controlling adult gliogenesis are still poorly understood. Here, we provide evidence for a homeostatic process that maintains the population of glial cells in the Drosophila adult brain. Flies lacking microRNA miR-31a start adult life with a normal complement of glia, but transiently lose glia due to apoptosis. miR-31a expression identifies a subset of predominantly gliogenic adult neural progenitor cells. Failure to limit expression of the predicted E3 ubiquitin ligase, Rchy1, in these cells results in glial loss...
March 20, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28298298/non-reciprocal-homeostatic-compensation-in-drosophila-potassium-channel-mutants
#13
Eugene Z Kim, Julie Vienne, Michael Rosbash, Leslie C Griffith
Homeostatic control of intrinsic excitability is important for long-term regulation of neuronal activity. In conjunction with many other forms of plasticity, intrinsic homeostasis helps neurons maintain stable activity regimes in the face of external input variability and destabilizing genetic mutations. In this study, we report a mechanism by which Drosophila melanogaster larval motor neurons stabilize hyperactivity induced by the loss of the delayed rectifying K(+) channel Shaker Cognate B (Shab), by upregulating the Ca(2+)-dependent K(+) channel encoded by the slowpoke (slo) gene...
March 15, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28298170/concussion-induces-hippocampal-circuitry-disruption-in-swine
#14
John A Wolf, Brian N Johnson, Victoria E Johnson, Mary E Putt, Kevin D Browne, Constance J Mietus, Daniel P Brown, Kathryn L Wofford, Douglas H Smith, M Sean Grady, Akiva S Cohen, D Kacy Cullen
Hippocampal-dependent deficits in learning and memory formation are a prominent feature of traumatic brain injury (TBI), however the role of the hippocampus in cognitive dysfunction after concussion (mild TBI) is unknown. We therefore investigated functional and structural changes in the swine hippocampus following TBI using a model of head rotational acceleration that closely replicates the biomechanics and neuropathology of closed-head TBI in humans. We examined neurophysiological changes using a novel ex vivo hippocampal slice paradigm with extracellular stimulation and recording in the dentate gyrus and CA1 occurring at 7 days following non-impact inertial TBI in swine...
March 16, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28297674/nanoscale-structural-plasticity-of-the-active-zone-matrix-modulates-presynaptic-function
#15
Oleg O Glebov, Rachel E Jackson, Christian M Winterflood, Dylan M Owen, Ellen A Barker, Patrick Doherty, Helge Ewers, Juan Burrone
The active zone (AZ) matrix of presynaptic terminals coordinates the recruitment of voltage-gated calcium channels (VGCCs) and synaptic vesicles to orchestrate neurotransmitter release. However, the spatial organization of the AZ and how it controls vesicle fusion remain poorly understood. Here, we employ super-resolution microscopy and ratiometric imaging to visualize the AZ structure on the nanoscale, revealing segregation between the AZ matrix, VGCCs, and putative release sites. Long-term blockade of neuronal activity leads to reversible AZ matrix unclustering and presynaptic actin depolymerization, allowing for enrichment of AZ machinery...
March 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/28288386/sleep-regulation-of-the-distribution-of-cortical-firing-rates
#16
REVIEW
Daniel Levenstein, Brendon O Watson, John Rinzel, György Buzsáki
Sleep is thought to mediate both mnemonic and homeostatic functions. However, the mechanism by which this brain state can simultaneously implement the 'selective' plasticity needed to consolidate novel memory traces and the 'general' plasticity necessary to maintain a well-functioning neuronal system is unclear. Recent findings show that both of these functions differentially affect neurons based on their intrinsic firing rate, a ubiquitous neuronal heterogeneity. Furthermore, they are both implemented by the NREM slow oscillation, which also distinguishes neurons based on firing rate during sequential activity at the DOWN→UP transition...
March 10, 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28285823/input-specific-plasticity-and-homeostasis-at-the-drosophila-larval-neuromuscular-junction
#17
Zachary L Newman, Adam Hoagland, Krishan Aghi, Kurtresha Worden, Sabrina L Levy, Jun Ho Son, Luke P Lee, Ehud Y Isacoff
Synaptic connections undergo activity-dependent plasticity during development and learning, as well as homeostatic re-adjustment to ensure stability. Little is known about the relationship between these processes, particularly in vivo. We addressed this with novel quantal resolution imaging of transmission during locomotive behavior at glutamatergic synapses of the Drosophila larval neuromuscular junction. We find that two motor input types, Ib and Is, provide distinct forms of excitatory drive during crawling and differ in key transmission properties...
March 22, 2017: Neuron
https://www.readbyqxmd.com/read/28279228/erratum-to-%C3%AE-amyloid-triggers-aberrant-over-scaling-of-homeostatic-synaptic-plasticity
#18
James Gilbert, Shu Shu, Xin Yang, Youming Lu, Ling-Qiang Zhu, Heng-Ye Man
No abstract text is available yet for this article.
March 9, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28275711/the-kinase-function-of-msk1-regulates-bdnf-signaling-to-creb-and-basal-synaptic-transmission-but-is-not-required-for-hippocampal-long-term-potentiation-or-spatial-memory
#19
Stephanie Daumas, Christopher J Hunter, Rajen B Mistry, Lorenzo Morè, Lucia Privitera, Daniel D Cooper, Kathleen M Reyskens, Harry T Flynn, Richard G M Morris, J Simon C Arthur, Bruno G Frenguelli
The later stages of long-term potentiation (LTP) in vitro and spatial memory in vivo are believed to depend upon gene transcription. Accordingly, considerable attempts have been made to identify both the mechanisms by which transcription is regulated and indeed the gene products themselves. Previous studies have shown that deletion of one regulator of transcription, the mitogen- and stress-activated kinase 1 (MSK1), causes an impairment of spatial memory. Given the ability of MSK1 to regulate gene expression via the phosphorylation of cAMP response element binding protein (CREB) at serine 133 (S133), MSK1 is a plausible candidate as a prime regulator of transcription underpinning synaptic plasticity and learning and memory...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28274846/acute-granulocyte-macrophage-colony-stimulating-factor-treatment-modulates-neuroinflammatory-processes-and-promotes-tactile-recovery-after-spinal-cord-injury
#20
Sandie Thomaty, Laurent Pezard, Christian Xerri, Jean-Michel Brezun
Neuroinflammation is known to play a key role in the prognosis of functional recovery after spinal cord injury (SCI). The involvement of microglial and mast cells in early and late stages of inflammation has been receiving increasing attention. This study was aimed at determining the influence of a pro-inflammatory cytokine, the granulocyte macrophage-colony stimulating factor (GM-CSF), on microglia and mast cell activation, glial scar formation and functional recovery following SCI. Rats were randomly injected with saline or GM-CSF one hour after a C4-C5 medio-lateral hemisection...
March 6, 2017: Neuroscience
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