keyword
https://read.qxmd.com/read/38537086/effect-of-dexmedetomidine-on-the-incidence-of-postoperative-acute-kidney-injury-in-living-donor-liver-transplantation-recipients-a-randomized-controlled-trial
#1
JOURNAL ARTICLE
Hye-Mee Kwon, Sa-Jin Kang, Sang-Bin Han, Jae Hwan Kim, Sung-Hoon Kim, In-Gu Jun, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Acute kidney injury (AKI) is one of the most common complications after living-donor liver transplantation (LDLT) that has great impact on recipient and graft outcomes. Dexmedetomidine is reported to decrease the incidence of AKI. In the current study, we investigated whether intraoperative dexmedetomidine infusion would reduce the AKI following LDLT. MATERIAL AND METHODS: In total, 205 adult patients undergoing elective LDLT were randomly assigned to the dexmedetomidine group (n=103) or the control group (n=102)...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38536864/sex-related-differences-in-pre-dialysis-trajectories-and-dialysis-initiation-a-french-nationwide-retrospective-study
#2
JOURNAL ARTICLE
Maxime Raffray, Louise Bourasseau, Cécile Vigneau, Cécile Couchoud, Clémence Béchade, François Glowacki, Sahar Bayat
BACKGROUND: In the last two decades, sex and gender differences have been documented in chronic kidney disease (CKD) management, including access to renal replacement therapy and its outcomes. The objectives of this study were to 1) compare the pre-dialysis healthcare utilization in men and women, and 2) examine the sex-specific factors associated with emergency dialysis start. METHODS: Adult patients with CKD who started dialysis in France in 2015 were extracted from the Renal Epidemiology and Information Network registry...
2024: PloS One
https://read.qxmd.com/read/38536830/association-of-anti-diabetic-drugs-and-covid-19-outcomes-in-patients-with-diabetes-mellitus-type-2-and-chronic-kidney-disease-nationwide-registry-analysis
#3
JOURNAL ARTICLE
Jelena Dimnjaković, Tamara Buble, Pero Ivanko, Tamara Poljičanin, Sandra Karanović Štambuk, Hana Brborović, Ognjen Brborović
INTRODUCTION: Patients with diabetes mellitus type 2 and chronic kidney disease (T2DM-CKD) have a 5 times higher risk of developing severe SARS-CoV-2 infection than those without these 2 diseases. The goal of this study is to provide information on T2DM-CKD and COVID-19 outcomes, with an emphasis on the association with anti-diabetic medications. METHODOLOGY: Study is designed as a retrospective cohort analysis covering the years 2020 and 2021. Data from the National Diabetes Registry (CroDiab) were linked to hospital data, primary healthcare data, Causes of Death Registry data, the SARS-CoV-2 vaccination database, and the SARS-CoV-2 test results database...
2024: PloS One
https://read.qxmd.com/read/38536785/work-disability-and-employment-status-among-advanced-chronic-kidney-disease-patients
#4
JOURNAL ARTICLE
Shing Shen Bay, Lydia Kamaruzaman, Rozita Mohd, Shamsul Azhar Shah
INTRODUCTION: Chronic kidney disease (CKD) is a major public health issue with significant socioeconomic impacts. In Malaysia, the prevalence of CKD in 2018 was 15%. Complications of CKD such as anaemia, mineral bone disease, and infections led to frequent hospitalizations resulting in work disability and unemployment. To date, there is no data of employment status of CKD patients in Malaysia. METHODS: A cross-sectional study of patients with advanced CKD (stage 4 and 5 non-dialysis) treated in our centre...
2024: PloS One
https://read.qxmd.com/read/38536621/triglyceride-glucose-index-predicts-major-adverse-cardiovascular-events-in-patients-with-chronic-kidney-disease
#5
JOURNAL ARTICLE
Kangbo Li, Qiqi Hou, Xinyi Li, Liying Tian, Liyan Wang, Shouling Wu, Quanle Han
BACKGROUND AND PURPOSE: Triglyceride-glucose (TyG) index has been regarded as a reliable surrogate marker of insulin resistance for predicting cardiovascular outcomes. The current study aimed to explore the associations between TyG index with major adverse cardiovascular events (MACE) in patients with chronic kidney disease (CKD). METHODS/PATIENTS: 13,517 patients with chronic kidney disease (CKD) from the Kailuan study were included. Patients were divided into quartiles according to the TyG index...
March 27, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38536515/blood-pressure-in-preterm-infants-with-bronchopulmonary-dysplasia-in-the-first-three-months-of-life
#6
JOURNAL ARTICLE
Judit Klara Kiss, Anna Gajda, Judit Mari, Csaba Bereczki
BACKGROUND: Neonatal hypertension is common in preterm infants with bronchopulmonary dysplasia (BPD). Our study aimed to examine blood pressure variation in the first three months of life in preterm BPD patients. METHODS: We conducted a retrospective, single-centre study at the Neonatal Intensive Care Unit of the University of Szeged, Hungary. We collected blood pressure data from 26 preterm infants (born at < 30 weeks gestation) with moderate or severe BPD over three years (2019-2021)...
March 27, 2024: Pediatric Nephrology
https://read.qxmd.com/read/38535424/cardiorespiratory-performance-in-kidney-and-liver-transplant-recipients-the-dilemma-to-combine-lifestyle-and-fitness
#7
JOURNAL ARTICLE
Giovannino Polara, Alessio Montagnoli, Roberto Palazzo, Melissa Orlandi, Gabriele Mascherini, Marco Corsi, Edoardo Falconi, Laura Stefani
It is widely demonstrated that moderate-intensity exercise is associated with improved fitness in non-communicable chronic diseases. However, there are no specific guidelines available for transplant recipients. Body composition is closely linked to exercise capacity, typically estimated by cardiopulmonary testing, but its potential correlation with cardiovascular health outcomes has not been investigated yet. This study aims to evaluate and compare cardiorespiratory performance and body composition in two groups of liver and kidney transplant recipients...
February 29, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535322/balancing-risks-and-benefits-sodium-glucose-cotransporter-2-inhibitors-and-the-risk-of-diabetic-ketoacidosis
#8
Jan P Kleinjan, Justin Blom, André P van Beek, Hjalmar R Bouma, Peter R van Dijk
Sodium-glucose cotransporter-2 inhibitors (SGLT2is) are a new class of drugs that have been proven beneficial in the management of diabetes, chronic kidney disease, and heart failure and in the mitigation of cardiovascular risk. The benefits of SGLT2i therapy have led to the rapid adoption of these drugs in clinical guidelines. Since the introduction of these drugs, concerns have arisen, as diabetic ketoacidosis (DKA) unexpectedly occurred in patients treated with SGLT2i. DKA is an infrequent but serious complication of SGLT2i therapy, and is potentially preventable...
March 13, 2024: Metabolites
https://read.qxmd.com/read/38535084/novel-biomarkers-in-evaluating-cardiac-function-in-patients-on-hemodialysis-a-pilot-prospective-observational-cohort-study
#9
JOURNAL ARTICLE
Lazar Chisavu, Viviana Mihaela Ivan, Adelina Mihaescu, Flavia Chisavu, Oana Schiller, Luciana Marc, Flaviu Bob, Adalbert Schiller
Chronic kidney disease patients treated by hemodialysis present a high cardiovascular morbidity and mortality. There is an imperative need for novel biomarkers for identifying these patients and to offer possible therapeutically interventions. We performed a prospective observational cohort study on 77 patients in the period of October 2021-October 2023. We measured serum plasma levels of interleukin 1-beta, galectin 3, human suppression of tumorigenicity factor 2, bone morphogenetic protein 2 and fibroblastic growth factor 23 at the inclusion site...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534719/antimicrobial-treatment-challenges-in-the-management-of-infective-spondylodiscitis-associated-with-hemodialysis-a-comprehensive-review-of-literature-and-case-series-analysis
#10
JOURNAL ARTICLE
Ioana A Ratiu, Corina F Moisa, Laura Țiburcă, Edy Hagi-Islai, Anamaria Ratiu, Gabriel Cristian Bako, Cristian Adrian Ratiu, Liana Stefan
Infective spondylodiscitis (ISD), the infection of vertebral bodies and surrounding tissues, is a rare complication with major impact on the long-term survival of hemodialysis (HD) patients. Although the most frequent etiology is staphylococcal , identifying these pathogens in blood cultures and biopsy cultures is often difficult. This paper aims to present suitable antibiotic combinations for the treatment of these patients, which is usually challenging in the case of an unidentified pathogen. We presented the therapies applied for 13 HD patients and 19 patients without chronic kidney disease (CKD), diagnosed with ISD between 2013 and 2023 in Bihor County...
March 20, 2024: Antibiotics
https://read.qxmd.com/read/38534505/biomedical-evaluation-of-early-chronic-kidney-disease-in-the-air-force-building-a-predictive-model-from-the-taiwan-military-health-service
#11
JOURNAL ARTICLE
Po-Jen Hsiao, Ruei-Lin Wang, Fu-Kang Hu, Fu-Ru Tsai, Chih-Chien Chiu, Wen-Fang Chiang, Kun-Lin Wu, Yuan-Kuei Li, Jenq-Shyong Chan, Chi-Ming Chu, Chi-Wen Chang
OBJECTIVE: Chronic kidney disease (CKD) is one of the most common diseases worldwide. The increasing prevalence and incidence of CKD have contributed to the critical problem of high medical costs. Due to stressful environments, aircrew members may have a high risk of renal dysfunction. A better strategy to prevent CKD progression in Air Force personnel would be to diagnosis CKD at an early stage. Since few studies have been conducted in Taiwan to examine the long-term trends in early CKD in Air Force aircrew members, this study is highly important...
February 28, 2024: Bioengineering
https://read.qxmd.com/read/38534325/indoxyl-sulfate-induced-valve-endothelial-cell-endothelial-to-mesenchymal-transition-and-calcification-in-an-integrin-linked-kinase-dependent-manner
#12
JOURNAL ARTICLE
Maria Delgado-Marin, Sandra Sánchez-Esteban, Alberto Cook-Calvete, Sara Jorquera-Ortega, Carlos Zaragoza, Marta Saura
Calcific Aortic Valve Disease (CAVD) is a significant concern for cardiovascular health and is closely associated with chronic kidney disease (CKD). Aortic valve endothelial cells (VECs) play a significant role in the onset and progression of CAVD. Previous research has suggested that uremic toxins, particularly indoxyl sulfate (IS), induce vascular calcification and endothelial dysfunction, but the effect of IS on valve endothelial cells (VECs) and its contribution to CAVD is unclear. Our results show that IS reduced human VEC viability and increased pro-calcific markers RUNX2 and alkaline phosphatase (ALP) expression...
March 8, 2024: Cells
https://read.qxmd.com/read/38534044/effect-of-a-plant-protein-rich-diet-on-postprandial-phosphate-metabolism-in-healthy-adult-men-a-randomised-controlled-trial
#13
JOURNAL ARTICLE
Kozue Uenishi, Nozomi Kawasaki, Haruka Iseki, Misato Nogata, Yuki Kawabata, Shinsuke Kido
BACKGROUND: This study examined the effects of animal protein- and plant protein-rich diets on postprandial phosphorus metabolism in healthy male subjects. METHODS: The study was conducted by randomised parallel-group comparison of healthy men aged 21-24 years. In Study 1, participants were divided into two groups and consumed either a 70% animal protein diet (AD, n = 6) or a 70% plant protein diet (PD, n = 6). In Study 2, participants were divided into three groups and consumed either AD (n = 10), PD (n = 10) or AD + DF, a 70% animal protein diet loaded with the same amount of fibre as PD (n = 9)...
March 27, 2024: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://read.qxmd.com/read/38533947/representation-of-real-world-adults-with-chronic-kidney-disease-in-clinical-trials-supporting-blood-pressure-treatment-targets
#14
JOURNAL ARTICLE
June Li, Jaejin An, Mengjiao Huang, Mengnan Zhou, Maria E Montez-Rath, Fang Niu, John J Sim, Alan C Pao, Vivek Charu, Michelle C Odden, Manjula Kurella Tamura
BACKGROUND: Little is known about how well trial participants with chronic kidney disease (CKD) represent real-world adults with CKD. We assessed the population representativeness of clinical trials supporting the 2021 Kidney Disease: Improving Global Outcomes blood pressure (BP) guidelines in real-world adults with CKD. METHODS AND RESULTS: Using a cross-sectional analysis, we identified patients with CKD who met the guideline definition of hypertension based on use of antihypertensive medications or sustained systolic BP ≥120 mm Hg in 2019 in the Veterans Affairs and Kaiser Permanente of Southern California...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533938/island-medicine-longitudinal-cohort-study-rapid-rise-in-chronic-kidney-disease-in-rural-and-remote-communities
#15
JOURNAL ARTICLE
Matthew D Jose, Laura Cuthbertson, James Burgess, Kim Jose, Timothy Saunder, Alex Kitsos, Jan Radford, Rajesh Raj
AIM: To determine the change in incidence and prevalence of chronic kidney disease (CKD) in rural and remote communities over the last decade. METHODS: We examined the change in age-standardized incidence and prevalence in Tasmania between 2010 and 2020, using a linked dataset that included any adult with a creatinine test taken in a community laboratory during the study period (n = 581 513; 87.8% of the state's adult population). We defined CKD as two measures of eGFR <60 mL/min per 1...
March 27, 2024: Nephrology
https://read.qxmd.com/read/38533915/differential-expression-of-serum-tm-paf-and-cd62p-in-patients-with-autologous-arteriovenous-fistula-and-the-correlation-with-vascular-access-function
#16
JOURNAL ARTICLE
Yan Jiang, Zongyang Liu, Liting Liu, Zhiqian Xiong, Yan Chen, Shuai Zhang, Chaojiang Su
BACKGROUND: End-stage renal disease (ESRD) is the final stage of chronic kidney disease (CKD). AIMS: We aimed to analyze the expression differences of serum thrombomodulin (TM), platelet-activating factor (PAF), and P-selectin (CD62P) in patients with autologous arteriovenous fistula (AVF) and the correlation with vascular access function. METHODS: The case data were retrospectively analyzed. Moreover, 160 patients with AVF maintenance hemodialysis were selected as the AVF group, and 150 healthy participants were selected as the healthy control group...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38533798/association-of-environmental-injustice-and-cardiovascular-diseases-and-risk-factors-in-the-united-states
#17
JOURNAL ARTICLE
Sumanth Khadke, Ashish Kumar, Sadeer Al-Kindi, Sanjay Rajagopalan, Yixin Kong, Khurram Nasir, Javaria Ahmad, Gary Adamkiewicz, Scott Delaney, Anju Nohria, Sourbha S Dani, Sarju Ganatra
BACKGROUND: While the impacts of social and environmental exposure on cardiovascular risks are often reported individually, the combined effect is poorly understood. METHODS AND RESULTS: Using the 2022 Environmental Justice Index, socio-environmental justice index and environmental burden module ranks of census tracts were divided into quartiles (quartile 1, the least vulnerable census tracts; quartile 4, the most vulnerable census tracts). Age-adjusted rate ratios (RRs) of coronary artery disease, strokes, and various health measures reported in the Prevention Population-Level Analysis and Community Estimates data were compared between quartiles using multivariable Poisson regression...
March 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38533476/identification-of-shared-signature-genes-and-immune-microenvironment-subtypes-for-heart-failure-and-chronic-kidney-disease-based-on-machine-learning
#18
JOURNAL ARTICLE
Xuefu Wang, Jin Rao, Xiangyu Chen, Zhinong Wang, Yufeng Zhang
BACKGROUND: A complex interrelationship exists between Heart Failure (HF) and chronic kidney disease (CKD). This study aims to clarify the molecular mechanisms of the organ-to-organ interplay between heart failure and CKD, as well as to identify extremely sensitive and specific biomarkers. METHODS: Differentially expressed tandem genes were identified from HF and CKD microarray datasets and enrichment analyses of tandem perturbation genes were performed to determine their biological functions...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38533378/incidence-and-risk-factors-for-cancer-in-people-with-type-1-diabetes-stratified-by-stages-of-diabetic-kidney-disease-a-nationwide-finnish-cohort-study
#19
JOURNAL ARTICLE
Maija Feodoroff, Valma Harjutsalo, Sari Mäkimattila, Per-Henrik Groop
BACKGROUND: Individuals with type 1 diabetes (T1D) have been reported to have increased overall risk of cancer. In addition, individuals with a kidney transplant/transplantation (KT) have markedly increased cancer risk due to chronic use of immunosuppressive agents. However, it has not been elucidated whether the observed excess cancer risk is related to KT or whether diabetic kidney disease (DKD) per se is a risk factor for cancer in individuals with T1D. METHODS: The study included 5035 individuals from the Finnish Diabetic Nephropathy Study (FinnDiane) and 14,061 control individuals without diabetes...
May 2024: The Lancet regional health. Europe
https://read.qxmd.com/read/38533295/hemodynamic-determinants-of-cardiac-surgery-associated-acute-kidney-injury
#20
JOURNAL ARTICLE
Sevag Demirjian, Faisal Bakaeen, W H Wilson Tang, Chase Donaldson, Jon Taliercio, Anne Huml, Crystal A Gadegbeku, A Marc Gillinov, Steven Insler
OBJECTIVES: Examine the: 1) relative role of hemodynamic determinants of acute kidney injury (AKI) obtained in the immediate postcardiac surgery setting compared with established risk factors, 2) their predictive value, and 3) extent mediation via central venous pressure (CVP) and mean arterial pressure (MAP). DESIGN: Retrospective observational study. The main outcome of the study was moderate to severe AKI, per kidney disease: improving global outcomes, within 14 days of surgery...
April 2024: Critical care explorations
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