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https://www.readbyqxmd.com/read/28938511/-obesity-and-kidney-disease-renal-consequences-of-an-epidemic
#1
Helmut Schiffl, Susanne Maria Lang
Overweight and obesity are widespread in the German population, affecting not only adults but also a significant number of children and adolescents. The risk to develop chronic kidney disease is markedly increased in overweight or adipose children, adolescents and adults.Overweight and obesity induced risk factors have a direct impact on the development of chronic renal disease (obesity-associated focal segmental glomerulosclerosis). They accelerate the progression of coexistent nephropathies (diabetic or hypertensive nephropathy, primary glomerulonephritides) and are independent risk factors for the development of acute kidney injury in critically ill patients...
September 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28938241/long-term-patient-and-kidney-survival-after-coronary-artery-bypass-grafting-percutaneous-coronary-intervention-or-medical-therapy-for-patients-with-chronic-kidney-disease-a-propensity-matched-cohort-study
#2
Tycho Vuurmans, Lee Er, Alexander Sirker, Ognjenka Djurdjev, Gerald Simkus, Adeera Levin
BACKGROUND: Revascularization in patients with chronic kidney disease (CKD) and coronary artery disease (CAD) is often deferred because of concern over progression of renal failure. HYPOTHESIS: Revascularization with either coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) leads to progression of renal failure, but improves survival compared with medical therapy in patients with CKD. PATIENTS AND METHODS: Linkages between the British Columbia Cardiac Registry and the British Columbia Renal Registry of patients with established CAD and CKD who underwent CABG, PCI, or were treated medically were propensity matched...
September 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28938238/impact-of-diabetes-mellitus-on-5-year-clinical-outcomes-in-patients-with-chronic-total-occlusion-lesions
#3
Ahmed Mashaly, Seung-Woon Rha, Byoung Geol Choi, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Hu Li, Min Suk Shim, Won Young Jang, Woohyeun Kim, Jun Hyuk Kang, Eun Jin Park, Jah Yeon Choi, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Diabetes mellitus (DM) is a major predictor of cardiovascular morbidity and mortality. However, there are limited data on the impact of DM in patients who have chronic total occlusion (CTO) lesion on long-term outcomes. PATIENTS AND METHODS: A total of 822 CTO patients who underwent coronary angiography, treated by either percutaneous coronary intervention or optimal medical therapy, were enrolled and divided into two groups: (i) diabetic group (n=363) and (ii) nondiabetic group (n=459)...
September 21, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28937442/orally-active-epoxyeicosatrienoic-acid-analogs
#4
William B Campbell, John D Imig, James M Schmitz, John R Falck
Biologically active epoxyeicosatrienoic acid (EET) regioisomers are synthesized from arachidonic acid by cytochrome P450 epoxygenases of endothelial, myocardial, and renal tubular cells. EETs relax vascular smooth muscle and decrease inflammatory cell adhesion and cytokine release. Renal EETs promote sodium excretion and vasodilation to decrease hypertension. Cardiac EETs reduce infarct size after ischemia-reperfusion injury and decrease fibrosis and inflammation in heart failure. In diabetes, EETs improve insulin sensitivity, increase glucose tolerance, and reduce the renal injury...
September 19, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28937076/prevalence-and-risk-factors-of-chronic-kidney-disease-in-newly-diagnosed-and-untreated-hypertensive-patients-in-cameroon-a-cross-sectional-study
#5
Félicite Kamdem, Fernando Kemta Lekpa, Marie Solange Doualla, Yvette Ngo Nouga, Olivier Donfack Sontsa, Elvis Temfack, Samuel Kingue
Chronic kidney disease (CKD) has emerged as a worldwide problem and is a major cause for comorbidity in hypertensive patients. In an attempt to enhance awareness and to help in establishing preventive measures and care, it is necessary to describe CKD among newly diagnosed and untreated hypertensive patients. We conducted a cross-sectional study to describe the characteristics of CKD among newly diagnosed, treatment naïve, hypertensive patients in four health-care centers in the city of Douala, Cameroon. Sociodemographic and biological data were collected and serum creatinine was measured by enzymatic - colorimetric methods...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937075/a-comparison-of-socioeconomic-level-among-hemodialysis-patients-and-normal-controls-in-the-fars-province-iran
#6
Leila Malekmakan, Maryam Pakfetrat, Arghavan Daneshian, Mehrab Sayadi
Chronic kidney disease (CKD) is a public health problem and it is suggested that low socioeconomic status (SES) may increase the risk of renal failure. The aim of this study was to report and compare the SES of hemodialysis patients (HD) and normal population in Shiraz, Iran. In this cross-sectional study, we evaluated 519 HD patients and 900 normal controls. We asked about SES using a questionnaire. The participants were categorized into three groups according to their SES as low, medium, and high SES. Of the 1419 participants, 454 (31...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937069/oral-health-in-diabetic-and-nondiabetic-patients-with-chronic-kidney-disease
#7
Lingam Amara Swapna, Pradeep Koppolu, Jyothi Prince
The objective of our study is to assess the subjective and objective oral manifestations and salivary pH in diabetic and nondiabetic uremic patients at a nephrology clinic. A total of 194 diabetic and nondiabetic patients with chronic kidney disease (CKD), who were divided into four groups, Group A, B, C, D, and who were attending a nephrology clinic were included in the study. Predialytic unstimulated whole salivary pH was recorded using pH- measuring strips. Subjective and objective findings were evaluated and recorded in the specially designed pro forma...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937066/relationship-of-insulin-resistance-to-vitamin-d-status-in-children-with-nondiabetic-chronic-kidney-disease
#8
Seçil Conkar, Sevgi Mir
Insulin Resistance is common in patients with mild-to-moderate stage chronic kidney disease (CKD), even when the glomerular filtration rate is within the normal range. This study aimed to investigate the association of IR and 25-hydroxyvitamin D levels. In this study, we evaluated the frequency of IR in predialysis patients and the association with 25-hydroxyvitamin (OH)D levels. A total of 32 non-diabetic patients with predialysis were included in the study. Homeostasis model assessment for insulin resistance (HOMA-IR) index was calculated to show presence of IR...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937061/long-term-evaluation-of-kidney-function-in-live-related-kidney-donors
#9
Kalpana S Mehta, Rudramani Swami, Atim Pajai, Sandip Bhurke, Abhishek Shirkande, Sunil Jawle
The consequences of live kidney donation on the donor health with main emphasis on postdonation blood pressure (BP), proteinuria, kidney size, and glomerular filtration rate (GFR) were evaluated. Twenty-five donors with minimum of six months postdonation duration were included in the study. Donor age at nephrectomy, duration postnephrectomy, systolic and diastolic BP measurement pre-and post-donation, postdonation, blood urea nitrogen, serum creatinine and 24-h proteinuria, blood sugar, two-dimensional echocardiogram were recorded...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28937054/the-importance-of-bone-biopsy-in-chronic-kidney-disease-mineral-bone-disorders
#10
REVIEW
Periklis Dousdampanis, Kostantina Trigka
Renal osteodystrophy (ROD) is not a uniform bone disease; it is a heterogeneous group of metabolic bone diseases due to chronic kidney disease (CKD). The traditional term of ROD does not accurately include the wide spectrum of "CKD-mineral and bone disorder" (CKD-MBD) and has been restricted to define the several specific histologic disturbances of bone disease associated with CKD. Circulating parathyroid hormone (PTH) and total alkaline phosphatase levels do not always reflect bone turnover in CKD-MBD, whereas bone biopsy provides precise information regarding bone pathology...
September 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28935472/treatment-of-superficial-femoral-artery%C3%A2-restenosis
#11
Andrew J Miller, Edwin A Takahashi, William S Harmsen, Kristin C Mara, Sanjay Misra
PURPOSE: To determine the predictors of restenosis, major adverse limb events (MALEs), postoperative death (POD), and all-cause mortality after repeat endovascular treatment of superficial femoral artery (SFA) restenosis. MATERIALS AND METHODS: This was a retrospective review of 440 patients with 518 SFA lesions who were treated between January 2002 and October 2011. Ninety-six limbs were treated for restenosis with bare metal stents (BMSs) or percutaneous transluminal angioplasty (PTA), of which 28 limbs developed another restenosis requiring a third procedure...
September 19, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28935364/urological-surveillance-and-medical-complications-among-ault-spina-bifida-medicare-beneficiaries
#12
Yahir Santiago-Lastra, Anne P Cameron, Julie Lai, Christopher Saigal, J Quentin Clemens
OBJECTIVE: To evaluate urologic follow-up and prevalence of medical complications among adult myelomeningocele (MMC) patients in the United States who are Medicare beneficiaries. METHODS: We performed a retrospective study using a 5% Medicare sample from 2007-2010. We defined acceptable minimum follow-up criteria as patients receiving all of the following: serum creatinine, upper urinary tract imaging and a urologist evaluation within a 2-year period. We queried associated diagnoses and relevant complications using ICD-9 codes, graded based on clinical impact...
September 18, 2017: Urology
https://www.readbyqxmd.com/read/28935359/disparities-by-sex-tracked-in-the-2015-national-healthcare-quality-and-disparities-report-trends-across-national-quality-strategy-priorities-health-conditions-and-access-measures
#13
Jennifer E Moore, Atlang Mompe, Ernest Moy
INTRODUCTION: Established by the Affordable Care Act, the National Quality Strategy (NQS) is the national policy goals aimed at improving the quality of health care for all Americans. The NQS established six priorities to provide better, more affordable care for individuals and communities. This is the first analysis of data on the NQS and access measures that focus on sex differences, health conditions, trends, and disparities. METHODS: Measures from the 2015 National Healthcare Quality and Disparities Report (QDR) for the four National Quality Strategy priorities (Patient Safety, Person Centered Care, Effective Treatment and Healthy Living), access to care, and health conditions for women were compared to measures for men...
September 19, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28934951/communicating-projected-survival-with-treatments-for-chronic-kidney-disease-patient-comprehension-and-perspectives-on-visual-aids
#14
Frances Dowen, Karishma Sidhu, Elizabeth Broadbent, Helen Pilmore
BACKGROUND: Mortality in end stage renal disease (ESRD) is higher than many malignancies. There is no data about the optimal way to present information about projected survival to patients with ESRD. In other areas, graphs have been shown to be more easily understood than narrative. We examined patient comprehension and perspectives on graphs in communicating projected survival in chronic kidney disease (CKD). METHODS: One hundred seventy-seven patients with CKD were shown 4 different graphs presenting post transplantation survival data...
September 21, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28934668/diabetes-mellitus-increased-all-cause-mortality-rate-among-newly-diagnosed-tuberculosis-patients-in-an-asian-population-a-nationwide-population-based-study
#15
Po-Yen Ko, Shi-Dou Lin, Ming-Chia Hsieh, Yu-Cheng Chen
AIMS: To investigate the effect of diabetes mellitus (DM) on all-cause mortality among patients with newly-diagnosed tuberculosis (TB) in an Asian population. We also identified risk factors for mortality in these patients. METHODS: The data were obtained from the National Health Insurance Research Database and included 9831 newly-diagnosed TB individuals and 1627 TB mortality cases in the period of 2000-2010. The mortality data were divided into a DM group and a non-DM group...
September 1, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28934517/human-epididymis-protein-4-as-a-potential-biomarker-of-chronic-kidney-disease-in-female-patients-with-normal-ovarian-function
#16
Tengfei Yuan, Yan Li
Background: Elevated serum concentrations of human epididymis protein 4 (HE4) have appeared in a large number of female patients with chronic kidney disease (CKD). However, it is unknow whether HE4 could be a potential biomarker for diagnosis of CKD. Objective: To evaluate whether serum HE4 is a potential biomarker of CKD in our cohort of 238 ethnic Han Chinese female patients, between the ages of 19 and 89 years. Methods: We selected 230 healthy control individuals and 238 female patients with CKD for inclusion in our study...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28934420/higher-prevalence-and-faster-progression-of-chronic-kidney-disease-in-human-immunodeficiency-virus-infected-middle-aged-individuals-compared-with-human-immunodeficiency-virus-uninfected-controls
#17
Katherine W Kooij, Liffert Vogt, Ferdinand W N M Wit, Marc van der Valk, Rosan A van Zoest, Abraham Goorhuis, Maria Prins, Frank A Post, Peter Reiss
Background: Human immunodeficiency virus (HIV)-infected individuals are at increased risk of chronic kidney disease (CKD). Human immunodeficiency virus infection, traditional CKD risk factors, and combination antiretroviral therapy (cART) may all contribute. Methods: We compared prevalence of renal impairment (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73m2), albuminuria (albumin/creatinine ratio ≥3 mg/mmol), and proximal renal tubular dysfunction (retinol-binding protein/creatinine ratio >2...
September 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28933798/pharmacokinetics-of-tecarfarin-and-warfarin-in-patients-with-severe-chronic-kidney-disease
#18
Mark Midei, Detlef Albrecht, Mintu P Turakhia, Daniel Ries, Thomas Marbury, William Smith, Debbie Dillon, Peter G Milner, Mark G Midei
Chronic kidney disease (CKD) complicates warfarin anticoagulation partially through its effect on CYP2C9 activity. Tecarfarin, a novel vitamin K antagonist, is not metabolized by CYP2C9. To evaluate the effect of CKD on their metabolism, we measured PK parameters of warfarin and tecarfarin in subjects with and without CKD. CKD subjects with estimated glomerular filtration rate < 30 mL/min not on dialysis (n = 13) were matched to healthy volunteers (HVs) (n = 10). Each subject was randomized to either warfarin 10 mg or tecarfarin 30 mg and was later crossed over to the other drug...
September 21, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28933341/c4d-expressing-glomerulopathy-and-proteinuria-post-transplantation-of-a-%C3%A2-too-big-for-size-mismatched-kidney-allograft-an-unusual-case-with-good-outcome%C3%A2
#19
Francois Gougeon, Alexei V Mikhailov, Keisha Gibson, Tomasz Kozlowski, Harsharan K Singh, Volker Nickeleit
A 5-year-old severely growth-retarded child with tubulointerstitial, oliguric end-stage renal disease received an adult-size kidney transplant. Three years post grafting under standard triple immunosuppression (mycophenolate mofetil, tacrolimus, and prednisone) de novo nephrotic range proteinuria without the nephrotic syndrome developed. Graft function was normal (serum creatinine: 0.2 - 0.3 mg/dL), there were no donor-specific HLA antibodies (DSA), and the urine sediment was inactive. Two biopsies collected 3 and 4 years post-transplantation showed severe glomerular capillary wall remodeling and associated pseudolinear C4d staining as morphologic correlates for the proteinuria...
September 21, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28933292/endothelial-progenitor-cells-at-the-interface-of-chronic-kidney-disease-from-biology-to-therapeutic-advancement
#20
Giuseppe Coppolino, Valeria Cernaro, Giordano Placida, Giuseppe Leonardi, Giorgio Basile, Davide Bolignano
The 'epidemic' diffusion of chronic kidney disease (CKD) needs the development of new therapeutic approaches to slow down the progression to end-stage renal disease. Endothelial Progenitor Cells (EPCs) are promising tools for the treatment of many human diseases as they promote the repair of damaged tissues. They were also suggested as therapy to repair renal tissue after an injury. Strategies using EPCs to induce a reparative process with functional restoring of a diseased kidney or to delay CKD are of two types: direct stem cells infusion or stimulating endogenous release of EPCs...
September 20, 2017: Current Medicinal Chemistry
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