Read by QxMD icon Read

Glutamate receptoes

G Meza
The main criteria asked to a GABAergic synapse, have been fulfilled by GABA at the recepto-neural junction of the sensory periphery of vestibular organs in vertebrates. These criteria include the demonstration of its precursor, its synthesizing and degrading (inactivating) mechanisms and their localization with the right polarity of a GABAergic synapse. A novel GABA depolarizing action with particular pharmacological characteristics and expression of subunits of GABA receptors of the synaptic type (GABAA, GABAB or a putative mixed GABAA-GABAC) that could account for these properties are discussed...
1998: Neurobiology
K Keinänen, A Jouppila, A Kuusinen
Recombinant fragments of the kainate-selective glutamate recepto subunit GluR-6 were expressed in insect cells and analysed for [3H]kainate binding activity in order to characterize the structural determinants responsible for ligand recognition. Deletion of the N-terminal approximately 400 amino-acid-residue segment and the C-terminal approximately 90 residues resulted in a membrane-bound core fragment which displayed pharmacologically native-like [3H]kainate binding properties. Further replacement of the membrane-embedded segments M1-M3 by a hydrophilic linker peptide gave rise to a soluble polypeptide which was accumulated in the culture medium...
March 15, 1998: Biochemical Journal
A M Ciabarra, J M Sullivan, L G Gahn, G Pecht, S Heinemann, K A Sevarino
Ionotropic glutamate receptors are composed of homomeric or heteromeric configurations of glutamate receptor subunits. We have cloned a member of a novel class of the rat ionotropic glutamate receptor family, termed chi-1. This subunit exhibits an average identity of 27% to NMDA subunits and 23% to non-NMDA subunits. Regional transcript levels of chi-1 are elevated just prior to and during the first postnatal week, with the highest levels present in the spinal cord, brainstem, hypothalamus, thalamus, CA1 field of the hippocampus, and amygdala...
October 1995: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
I A Sytinsky
The preferable conformations of the inhibitory transmitter gamma-aminobutyric acid (GABA) and its specific inhibitor bicuculline are due to the occupation of the GABAreceptor by a part of the bicuculline molecule that is isosteric with the biologically active conformation of GABA. In the present review are described characteristics of sodium-independence receptor sites and evaluated the regional distribution of postsynaptic receptor binding for GABA in the central nervous system. The postsynaptic GABA receptor has been labeled by direct binding of 3H-GABA...
May 1978: Biokhimii︠a︡
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"