Hanyue Li, Yihui Li, Lina Su, Ke Zheng, Yue Zhang, Jing Li, Feng Lv, Mengjie Huang, Ting Chen, Hanjie Zhang, Zhaoqing Shi, Dunwan Zhu, Xia Dong, Weiwei Zeng, Lin Mei
Nanomedicine has reshaped the landscape of cancer treatment. However, its efficacy is still hampered by innate tumor defense systems that rely on adenosine triphosphate (ATP) for fuel, including damage repair, apoptosis resistance, and immune evasion. Inspired by the naturally enzymatic reaction of glucose oxidase (GOx) with glucose, here a novel "two birds with one stone" technique for amplifying enzyme-mediated tumor apoptosis and enzyme-promoted metabolic clearance is proposed and achieved using GOx-functionalized rhenium nanoclusters-doped polypyrrole (Re@ReP-G)...
March 6, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)