keyword
MENU ▼
Read by QxMD icon Read
search

hsp70 cancer

keyword
https://www.readbyqxmd.com/read/29156817/near-infrared-photothermal-therapy-using-anti-egfr-gold-nanorod-conjugates-for-triple-negative-breast-cancer
#1
Meihua Zhang, Hoe Suk Kim, Tiefeng Jin, Jisu Woo, Yin Ji Piao, Woo Kyung Moon
Current EGFR-targeted therapy for triple negative breast cancer (TNBC) has produced disappointing results. A rational therapeutic strategy to improve EGFR-targeted treatment for TNBC is therefore needed. In this study we evaluated the feasibility of treating TNBC using photoacoustic imaging (PAI)-guided near-infrared photothermal therapy (NIR-PTT) with anti-EGFR-conjugated gold nanorods (anti-EGFR-GN). NIR-PTT combined with anti-EGFR-GN exerted synergistic anti-proliferative and apoptotic actions through upregulation of HSP70 and cleaved caspase-3, downregulation of Ki-67 and EGFR, and inhibition of several intracellular signaling molecules (mTOR, AKT, ERK1/2 and FAK)...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137866/development-of-noviomimetics-that-modulate-molecular-chaperones-and-manifest-neuroprotective-effects
#2
Leah K Forsberg, Mercy Anyika, Zhenyuan You, Sean Emery, Mason McMullen, Rick T Dobrowsky, Brian S J Blagg
Heat shock protein 90 (Hsp90) is a chaperone under investigation for the treatment of cancer and neurodegenerative diseases. Neuroprotective Hsp90 C-terminal inhibitors derived from novobiocin (novologues) include KU-32 and KU-596. These novologues modulate molecular chaperones and result in an induction of Heat Shock Protein 70 (Hsp70). "Noviomimetics" replace the synthetically complex noviose sugar with a simple cyclohexyl moiety to maintain biological efficacy as compared to novologues KU-596 and KU-32...
October 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29137250/molecular-chaperones-in-the-acquisition-of-cancer-cell-chemoresistance-with-mutated-tp53-and-mdm2-up-regulation
#3
Zuzanna Tracz-Gaszewska, Marta Klimczak, Przemyslaw Biecek, Marcin Herok, Marcin Kosinski, Maciej B Olszewski, Patrycja Czerwińska, Milena Wiech, Maciej Wiznerowicz, Alicja Zylicz, Maciej Zylicz, Bartosz Wawrzynow
Utilizing the TCGA PANCAN12 dataset we discovered that cancer patients with mutations in TP53 tumor suppressor and overexpression of MDM2 oncogene exhibited decreased survival post treatment. Interestingly, in the case of breast cancer patients, this phenomenon correlated with high expression level of several molecular chaperones belonging to the HSPA, DNAJB and HSPC families. To verify the hypothesis that such a genetic background may promote chaperone-mediated chemoresistance, we employed breast and lung cancer cell lines that constitutively overexpressed heat shock proteins and have shown that HSPA1A/HSP70 and DNAJB1/HSP40 facilitated the binding of mutated p53 to the TAp73α protein...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29111316/concentrations-of-sp-a-and-hsp70-are-associated-with-polarization-of-macrophages-in-pleural-effusions-of-non-small-cell-lung-cancer
#4
Mariusz Kaczmarek, Malgorzata Lagiedo, Agnieszka Masztalerz, Magdalena Kozlowska, Agata Nowicka, Beata Brajer, Halina Batura-Gabryel, Jan Sikora
Damage-associated molecular pattern (DAMP) molecules can initiate an immune response through Toll-like receptors (TLRs). DAMPs are released from cells as a response to the extracellular danger and can be by-products of tissue damage. In cancer microenvironment necrotic cells release debris which has potency to become DAMPs. Non-small cell lung cancer (NSCLC) is often accompanied by pleural effusion (PE), which contains a variety of DAMPs. Surfactant protein A (SP-A) and heat shock protein 70 (Hsp70) are important DAMPs in the respiratory tract...
October 27, 2017: Immunobiology
https://www.readbyqxmd.com/read/29102083/cracking-the-chaperone-code-cellular-roles-for-hsp70-phosphorylation
#5
Nitika, Andrew W Truman
Heat shock protein 70 (Hsp70) is a molecular chaperone required for protein folding, cell viability, and cancer cell proliferation. Recent studies suggest that Hsp70 phosphorylation regulates important cellular processes, such as cell cycle progression, apoptosis, protein degradation, and resistance to anticancer therapeutics.
October 25, 2017: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/29093708/dynamics-of-heat-shock-protein-70-serum-levels-as-a-predictor-of-clinical-response-in-non-small-cell-lung-cancer-and-correlation-with-the-hypoxia-related-marker-osteopontin
#6
Christian Ostheimer, Sophie Gunther, Matthias Bache, Dirk Vordermark, Gabriele Multhoff
Hypoxia mediates resistance to radio(chemo)therapy (RT) by stimulating the synthesis of hypoxia-related genes, such as osteopontin (OPN) and stress proteins, including the major stress-inducible heat shock protein 70 (Hsp70). Apart from its intracellular localization, Hsp70 is also present on the plasma membrane of viable tumor cells that actively release it in lipid vesicles with biophysical characteristics of exosomes. Exosomal Hsp70 contributes to radioresistance while Hsp70 derived from dying tumor cells can serve as a stimulator of immune cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29061506/panaxynol-a-natural-hsp90-inhibitor-effectively-targets-both-lung-cancer-stem-and-non-stem-cells
#7
Huong Thuy Le, Huy Truong Nguyen, Hye-Young Min, Seung Yeob Hyun, Soonbum Kwon, Yeongcheol Lee, Thi Hong Van Le, Jeeyeon Lee, Jeong Hill Park, Ho-Young Lee
Cancer stem-like cells (CSCs) contribute to tumor recurrence and chemoresistance. Hence, strategies targeting CSCs are crucial for effective anticancer therapies. Here, we demonstrate the capacities of the non-saponin fraction of Panax ginseng and its active principle panaxynol to inhibit Hsp90 function and viability of both non-CSC and CSC populations of NSCLC in vitro and in vivo. Panaxynol inhibited the sphere forming ability of NSCLC CSCs at nanomolar concentrations, and micromolar concentrations of panaxynol suppressed the viability of NSCLC cells (non-CSCs) and their sublines carrying acquired chemoresistance with minimal effect on normal cells derived from various organs...
October 20, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29023986/evaluation-of-short-and-long-term-efficacy-of-chemoradiotherapy-for-advanced-cervical-cancer-using-hsp70-protein-combined-with-multimodal-mri
#8
Yun-Xiang Qi, Kun Liu, Jun Yin, Lu Li
This study aims to evaluate the efficacy of chemoradiotherapy for advanced cervical cancer using heat shock protein 70 (HSP70) combined with multimodal MRI. The protein expressions of HSP70 in biopsy specimens obtained from 101 patients with cervical cancer were detected by immunohistochemistry. Plain MRI scan, DWI, DCE-MR and MRS were performed before and after a period of six months of chemoradiotherapy. All patients were assigned into the complete response (CR) and partial response (PR) groups. HSP70 protein expression, tumor diameter and tumor volume were lower in the CR group than in the PR group...
October 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29017815/rna-polymerase-ii-pausing-and-transcriptional-regulation-of-the-hsp70-expression
#9
REVIEW
Heeyoun Bunch
Heat-shock proteins (HSPs) belong to the chaperone protein family whose expression is induced by different stresses including heat-shock. In response to the extracellular or intrinsic stimuli and stresses, HSPs play important roles in the maintenance of cellular homeostasis. HSP70, a major HSP protein (molecular weight, 70 KDa), regulates diverse cellular pathways including protein quality control, translation, immune response, and cancer survival. As a critical cellular defense system to minimize damages from cellular stresses, HSP70 expression and transcriptional activation are rapidly regulated, mainly through the action of a transcription activator, Heat shock factor 1 (HSF1)...
October 3, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28971453/gold-rods-irradiated-with-ultrasound-for-combination-of-hyperthermia-and-cancer-chemotherapy
#10
Andre Barros, Carlos Austerlitz, Ioannis Gkigkitzis, Diana Campos, Jeyce Andrade, Christina Peixoto, Jaciana Aguiar, Silene Nascimento, Teresinha G Silva, Ioannis Haranas
PURPOSE: The aim of this study was to analyze feasibility (in vitro and in vivo) the use of hyperthermia produced by gold rods irradiated with ultrasound and their combination with chemotherapy with doxorubicin. MATERIALS AND METHODS: initially was determined the cell viability and Hsp70 levels after treatment by gold rods irradiated with ultrasound (GR+U) in cell culture. The pretreatment with GR+U combined with doxorubicin (DOX) was evaluated from IC50, caspase-3 expression and mechanisms of cell death by electron microscopy...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28970360/heat-shock-protein-70-hsp70-suppresses-rip1-dependent-apoptotic-and-necroptotic-cascades
#11
Sharan R Srinivasan, Laura C Cesa, Xiaokai Li, Olivier Julien, MIn Zhuang, Hao Shao, Jooho Chung, Ivan Maillard, James A Wells, Colin Duckett, Jason E Gestwicki
Heat shock protein 70 (Hsp70) is a molecular chaperone that binds to "client" proteins and protects them from protein degradation. Hsp70 is essential for the survival of many cancer cells, but it is not yet clear which of its clients are involved. Using structurally distinct chemical inhibitors, we found that many of the well-known clients of the related chaperone, Hsp90, are not strikingly responsive to Hsp70 inhibition. Rather, Hsp70 appeared to be important for the stability of the RIP1 (RIPK1) regulators: cIAP1/2 (BIRC1 and BIRC3), XIAP, and cFLIPS/L (CFLAR)...
September 28, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28951871/recombinant-vaccinia-viruses-coding-transgenes-of-apoptosis-inducing-proteins-enhance-apoptosis-but-not-immunogenicity-of-infected-tumor-cells
#12
Olga Koval, Galina Kochneva, Anastasiya Tkachenko, Olga Troitskaya, Galina Sivolobova, Antonina Grazhdantseva, Anna Nushtaeva, Elena Kuligina, Vladimir Richter
Genetic modifications of the oncolytic vaccinia virus (VV) improve selective tumor cell infection and death, as well as activation of antitumor immunity. We have engineered a double recombinant VV, coding human GM-CSF, and apoptosis-inducing protein apoptin (VV-GMCSF-Apo) for comparing with the earlier constructed double recombinant VV-GMCSF-Lact, coding another apoptosis-inducing protein, lactaptin, which activated different cell death pathways than apoptin. We showed that both these recombinant VVs more considerably activated a set of critical apoptosis markers in infected cells than the recombinant VV coding GM-CSF alone (VV-GMCSF-dGF): these were phosphatidylserine externalization, caspase-3 and caspase-7 activation, DNA fragmentation, and upregulation of proapoptotic protein BAX...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28950684/deregulation-of-mir-34a-and-its-chaperon-hsp70-in-hepatitis-c-virus-induced-liver-cirrhosis-and-hepatocellular-carcinoma-patients
#13
Rasha H Shehata, Soha S Abdelmoneim, Osman A Osman, Ahmad F Hasanain, Amany Osama, Sahar S Abdelmoneim, Eman A Toraih
Background: MicroRNA deregulation may occur during hepatocellular carcinoma (HCC) genesis and progression stages. MicroRNA-34a (miR-34a) functions as a tumor suppressor and is down-regulated or silenced in a variety of human cancers, while heat shock proteins (Hsps) play important roles in assisting protein folding and preventing both protein aggregation and transport across membranes. The present study aimed to evaluating serum expression of miR-34a and its target Hsp70 for early detection of HCC in patients with liver cirrhosis (LC), focusing on correlations with clinicopathological features...
September 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28928813/heat-shock-protein-70-downregulation-inhibits-proliferation-migration-and-tumorigenicity-in-hepatocellular-carcinoma-cells
#14
Ju Xiong, Xue-Mei Jiang, Shan-Shan Mao, Xiang-Nan Yu, Xiao-Xi Huang
The overexpression of heat shock protein 70 (HSP70), a major stress-inducible heat shock protein, has been identified to enhance the proliferation, survival, invasion and metastasis of diverse types of human cancer. However, its role in hepatocellular carcinoma (HCC) remains poorly understood. The present study demonstrated that HSP70 expression was higher in tested HCC cell lines, compared with the normal hepatocyte LO2, and the suppression of HSP70 significantly inhibited the proliferation of SMMC-7721 and Hep3B cells...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928431/tumor-induces-muscle-wasting-in-mice-through-releasing-extracellular-hsp70-and-hsp90
#15
Guohua Zhang, Zhelong Liu, Hui Ding, Yong Zhou, Hoang Anh Doan, Ka Wai Thomas Sin, Zhiren J Zhu, Rene Flores, Yefei Wen, Xing Gong, Qingyun Liu, Yi-Ping Li
Cachexia, characterized by muscle wasting, is a major contributor to cancer-related mortality. However, the key cachexins that mediate cancer-induced muscle wasting remain elusive. Here, we show that tumor-released extracellular Hsp70 and Hsp90 are responsible for tumor's capacity to induce muscle wasting. We detected high-level constitutive release of Hsp70 and Hsp90 associated with extracellular vesicles (EVs) from diverse cachexia-inducing tumor cells, resulting in elevated serum levels in mice. Neutralizing extracellular Hsp70/90 or silencing Hsp70/90 expression in tumor cells abrogates tumor-induced muscle catabolism and wasting in cultured myotubes and in mice...
September 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/28900243/normothermic-microwave-irradiation-induces-death-of-hl-60-cells-through-heat-independent-apoptosis
#16
Mamiko Asano, Satoshi Tanaka, Minoru Sakaguchi, Hitoshi Matsumura, Takako Yamaguchi, Yoshikazu Fujita, Katsuyoshi Tabuse
Microwaves have been used in various cancer therapies to generate heat and increase tumor cell temperature; however, their use is limited by their side-effects in normal cells and the acquisition of heat resistance. We previously developed a microwave irradiation method that kills cultured cancer cells, including a human promyelomonocytic leukemia (HL-60) cell line, by maintaining a cellular temperature of 37 °C during treatment. In the present study, we investigated the mechanisms underlying HL-60 cell death during this treatment...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28880092/using-peptide-aptamer-targeted-polymers-as-a-model-nanomedicine-for-investigating-drug-distribution-in-cancer-nanotheranostics
#17
Yongmei Zhao, Zachary H Houston, Joshua D Simpson, Liyu Chen, Nicholas L Fletcher, Adrian V Fuchs, Idriss Blakey, Kristofer J Thurecht
Theranostics is a strategy that combines multiple functions such as targeting, stimulus-responsive drug release, and diagnostic imaging into a single platform, often with the aim of developing personalized medicine.1,2 Based on this concept, several well-established hyperbranched polymeric theranostic nanoparticles were synthesized and characterized as model nanomedicines to investigate how their properties affect the distribution of loaded drugs at both the cell and whole animal levels. An 8-mer peptide aptamer was covalently bound to the periphery of the nanoparticles to achieve both targeting and potential chemosensitization functionality against heat shock protein 70 (Hsp70)...
October 2, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28859986/kribb11-accelerates-mcl-1-degradation-through-an-hsf1-independent-mule-dependent-pathway-in-a549-non-small-cell-lung-cancer-cells
#18
Min-Jung Kang, Hye Hyeon Yun, Jeong-Hwa Lee
The Bcl-2 family protein, Mcl-1 is known to have anti-apoptotic functions, and depletion of Mcl-1 by cellular stresses favors the apoptotic process. Moreover, Mcl-1 levels are frequently increased in various cancer cells, including non-small cell lung cancer (NSCLC), and is implicated in resistance to conventional chemotherapy and in cancer metastasis. In this study, we demonstrated that KRIBB11 accelerates the proteasomal degradation of Mcl-1 in the NSCLC cell line, A549. While KRIBB11 is an inhibitor of HSF1, we found that KRIBB11 induced Mcl-1 degradation in an HSF1-independent manner...
October 21, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28843722/macrophage-cell-derived-exosomes-staphylococcal-enterotoxin-b-against-fibrosarcoma-tumor
#19
Elham Behzadi, Hamideh Mahmoodzadeh Hosseini, Raheleh Halabian, Abbas Ali Imani Fooladi
Targeted immune therapies are a modern approach to harness the immunity to treat cancer patients. Exosomes (EXOs) are nano-vesicles used for drug delivery in cancer treatment. We aimed to assess the effectiveness of novel designed EXO structures for immunotherapy alone and in combination with other components in animal models. EXO derived from untreated macrophage (EXO), WEHI-164 cell lysate treated EXO (EXOLys), HSP70 enriched WEHI-164 cell lysate treated EXO (EXOHSP70), Naloxone (NLX) treated EXO (EXONLX), Propranolol (PRP) treated EXO (EXOPRP) and staphylococcal enterotoxin B (SEB) anchored to three kinds of EXOs designated as EXO/SEB, EXOLys/SEB, EXOHSP70/SEB were purified from J774 cell line...
October 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28831912/clinical-prognostic-and-therapeutic-significance-of-heat-shock-proteins-in-cancer
#20
Jasleen Saini, Pushpender K Sharma
Heat shock proteins (HSPs) constitute a group of proteins that play crucial role in process of proteins folding. HSPs are also known to modulate number of key apoptotic factors. High expression of these proteins is reported in array of cancers, such as breast, prostate, colorectal, lung, ovarian, gastric, oral and esophageal cancer. Ample amount of investigations carried out on variety of cancers suggests HSPs as a promising hallmark in cancers. Their expression profile in several tumors elucidates that they help in proliferation, invasion, metastasis and death of cancerous cells...
August 23, 2017: Current Drug Targets
keyword
keyword
117127
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"