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https://www.readbyqxmd.com/read/29690727/-clinical-experience-and-next-generation-sequencing-analysis-of-encephalitis-caused-by-pseudorabies-virus
#1
W L Zhao, Y H Wu, H F Li, S Y Li, S Y Fan, H L Wu, Y J Li, Y L Lü, J Han, W C Zhang, Y Zhao, G L Li, X D Qiao, H T Ren, Y C Zhu, B Peng, L Y Cui, H Z Guan
Objective: To detect potential pathogens including pseudorabies virus in patients with encephalitis of unknown etiology in China and describe novel encephalitic entities. Methods: Patients with clinically suspected infectious encephalitis were enrolled in a multicenter study to identify the pathogens in PUMCH Encephalitis Program.Next-generation sequencing(NGS) of cerebrospinal fluid (CSF) was used in patients with encephalitis of unknown etiology enrolled from 2016 to 2017.The patients diagnosed as PRV encephalitis were studied to describe this novel entity...
April 17, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29687155/takayasu-arteritis-in-childhood-misdiagnoses-at-disease-onset-and-associated-diseases
#2
Gleice Clemente, Clovis A Silva, Silvana B Sacchetti, Virginia P L Ferriani, Sheila K Oliveira, Flavio Sztajnbok, Blanca E R G Bica, André Cavalcanti, Teresa Robazzi, Marcia Bandeira, Maria Teresa Terreri
Juvenile-Takayasu arteritis (j-TA) is a difficult diagnosis and some patients develop uncommon manifestations and associated diseases that may contribute to the delayed diagnosis. Our aim was to identify the misdiagnoses, the associated diseases and the atypical manifestations observed in a j-TA Brazilian multicentre study. 71 children and adolescents who met the classification criteria for j-TA were included. The misdiagnoses, the associated diseases and the atypical manifestations were evaluated. 19 (26.8%) patients had misdiagnoses...
April 23, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29683400/molecular-evidence-of-rickettsia-in-human-and-dog-blood-in-bangkok
#3
Nanthanida Mongkol, Yupin Suputtamongkol, Piyanan Taweethavonsawat, Suporn Foongladda
Rickettsia spp. has been detected in dog fleas in Bangkok, Thailand. With the intent of collecting evidence to confirm the presence of rickettsioses in dogs and to assess the level of associated potential for accidental human infection, human buffy coat from patients with fever of unknown origin (n = 168), whole blood samples from dogs (n = 353), and 19 flea groups from our dog sample population were studied during the 2012 to 2014 study period. The presence of Rickettsia was investigated by molecular detection of 23S rRNA gene of Rickettsia genus, citrate synthase (gltA) gene, and 17-kDa outer membrane gene...
April 23, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29682404/possible-association-of-multicentric-castleman-s-disease-with-autoimmune-lymphoproliferative-syndrome
#4
REVIEW
Hiroyuki Minemura, Yoshinori Tanino, Kazuhiko Ikeda
Multicentric Castleman's disease (MCD) is lymphoproliferative disorder characterized by systemic inflammatory symptoms such as fever and weight loss. Human herpes virus-8 (HHV-8) is thought to be a causable pathogen in all HIV-positive and some HIV-negative MCD patients. Furthermore, the term idiopathic MCD (iMCD) was recently proposed to represent a group of HIV-negative and HHV-8-negative patients with unknown etiologies. Although the international diagnostic criteria for iMCD require exclusion of infection-related disorders, autoimmune/autoinflammatory diseases and malignant/lymphoproliferative disorders to make an iMCD diagnosis, the relationships and differences between these disorders and MCD have not yet been clarified...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29682388/granulomatosis-with-polyangiitis-localized-in-the-greater-omentum
#5
Ryuji Komine, Takashi Kobayashi, Hiro Uehara, Keisuke Minamimura, Kazuhiko Mori, Toru Hirata, Atsushi Shimizu, Masaya Mori
Granulomatosis with polyangiitis (GPA) is known as anti-neutrophil cytoplasmic antibody- (ANCA-) associated small vessel vasculitis and typically manifests as pulmonary-renal syndrome, but the disease is not limited to pulmonary or renal systems. The inflammation can involve whole body organs. In addition, the ANCA titer does not always become positive. Here, we describe the case of a 91-year-old man who presented with umbilical pain and fever of unknown origin. Only the increased computed tomography value of the greater omentum suggested intra-abdominal inflammation; however, serological examinations, including the ANCA level, could not reveal the focus or cause of symptoms...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29682245/caustic-ingestion-in-children-in-south-of-iran-a-two-year-single-center-study
#6
Seyed Mohsen Dehghani, Maryam Bahmanyar, Hazhir Javaherizadeh
BACKGROUND Caustic ingestion is one of the most important injuries during childhood, which leads to serious sequel. In this study, we evaluated the clinical manifestations, endoscopic appearance, complications, and treatment results in patients with caustic ingestion in our hospital. METHODS Hospital chart of patients with caustic ingestion who admitted to Nemazee Teaching Hospital affiliated to Shiraz University of Medical Sciences during a 2-year period (2015-2016) were reviewed retrospectively. The age, sex, nature of the caustic agent, clinical presentations, grade of injury in endoscopy, degree of parents' education, site of ingestion, accidental or intentional attempts, complications, and outcomes were reviewed...
January 2018: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29679253/fever-of-unknown-origin-fuo-cmv-infectious-mononucleosis-or-lymphoma
#7
Burke A Cunha, Karishma Chawla
Fever of unknown origin (FUO) refers to fevers of > 101 °F that persist for > 3 weeks and remain undiagnosed after a focused inpatient or outpatient workup. FUO may be due to infectious, malignant/neoplastic, rheumatic/inflammatory, or miscellaneous disorders. The FUO category determines the focus of the diagnostic workup. In the case presented of an FUO in a young woman, there were clinical findings of both CMV infectious mononucleosis or a lymphoma, e.g., highly elevated ESR, elevated ferritin levels, and elevated ACE level, β-2 microglobulins...
April 20, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29678951/cyclooxygenase-1-and-2-play-contrasting-roles-in-listeria-stimulated-immunity
#8
Erin Theisen, Courtney E McDougal, Masako Nakanishi, David M Stevenson, Daniel Amador-Noguez, Daniel W Rosenberg, Laura J Knoll, John-Demian Sauer
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) activity and are commonly used for pain relief and fever reduction. NSAIDs are used following childhood vaccinations and cancer immunotherapies; however, how NSAIDs influence the development of immunity following these therapies is unknown. We hypothesized that NSAIDs would modulate the development of an immune response to Listeria monocytogenes -based immunotherapy. Treatment of mice with the nonspecific COX inhibitor indomethacin impaired the generation of cell-mediated immunity...
April 20, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29670775/mesenteric-panniculitis-presenting-as-fever-of-unknown-etiology-in-a-patient-with-history-of-abdominal-surgery
#9
Christopher P Irwin, Joo B Lee, Andrew Kim, Ijagha Eme, Christina Schofield, George Mount
Mesenteric panniculitis is characterized by nonspecific fibrous inflammation of the small bowel mesentery, appendix, and mesoappendix. Clinical course is usually benign and outcome is favorable. We report a case of mesenteric panniculitis presenting as fever of unknown etiology in a patient with history of abdominal surgery.
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29669701/crizotinib-in-patients-with-advanced-inoperable-inflammatory-myofibroblastic-tumours-with-and-without-anaplastic-lymphoma-kinase-gene-alterations-european-organisation-for-research-and-treatment-of-cancer-90101-create-a-multicentre-single-drug-prospective-non
#10
Patrick Schöffski, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Sandra J Strauss, Silvia Stacchiotti, Piotr Rutkowski, Lars H Lindner, Michael G Leahy, Antoine Italiano, Nicolas Isambert, Maria Debiec-Rychter, Raf Sciot, Thomas Van Cann, Sandrine Marréaud, Axelle Nzokirantevye, Sandra Collette, Agnieszka Wozniak
BACKGROUND: An inflammatory myofibroblastic tumour (IMFT) is a rare mesenchymal neoplasm characterised by anaplastic lymphoma kinase (ALK) gene rearrangements. We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations. METHODS: We did a multicentre, biomarker-driven, single-drug, non-randomised, open-label, two-stage phase 2 trial (European Organisation for Research and Treatment of Cancer 90101 CREATE) at 13 study sites (five university hospitals and eight specialty clinics) in eight European countries (Belgium, France, Germany, Italy, Netherlands, Poland, Slovakia, and the UK)...
April 12, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29666738/combined-diagnosis-of-systemic-lupus-erythematosus-and-tuberculosis-in-an-irish-adolescent-female
#11
Kene Ebuka Maduemem, Comfort O Adedokun, Adela Vatca
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown aetiology, which can affect any organ system. Tuberculosis (TB) is a common infection in SLE because of immune dysregulation associated with the latter. We report a case of an adolescent female who presented with a year's history of polyarticular arthralgia and fever. Physical examination revealed a large left effusion that needed drainage. Investigations revealed a combined diagnosis of SLE and TB. Management comprised quadruple anti-TB therapy and SLE treatment...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29664539/-atypical-subacute-thyroiditis-in-combination-with-grave-s-disease-diagnostic-difficulties-in-a-case-report
#12
Emmanouela Koutouridou, Tereza Planck, Erik Uddman, Mikael Lantz
Subacute thyroiditis is a common inflammatory disorder of the thyroid gland, possibly of viral etiology, that typically presents with neck pain, fever and tenderness on palpation of the thyroid gland. Graves' disease is an autoimmune thyroid disorder caused by stimulation of the thyroid gland by thyrotropin receptor antibodies (TRAb). The development of Graves´ disease and subacute thyroiditis simultaneously is an uncommon condition and only a few cases have been reported. In this article we present a case of a 46-year old woman diagnosed with Graves´ disease who was started on thiamazole and weeks later developed high fever...
April 13, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29656120/systemic-inflammatory-response-syndromes-in-the-era-of-interventional-cardiology
#13
REVIEW
Riccardo Gorla, Raimund Erbel, Kim A Eagle, Eduardo Bossone
Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophysiology procedures (EP), and transcatheter aortic valve implantation (TAVI). In these settings, a comprehensive understanding of the triggers, pathogenesis as well as a common diagnostic/therapeutic algorithm is lacking and will be discussed in this review...
April 12, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29650846/-two-stage-radical-resection-of-a-case-of-colon-cancer-with-abdominal-wall-invasion-and-cholangiocarcinoma
#14
Takashi Sugimoto, Hidenori Kiyochi, Yohei Hosoda, Izumi Komoto, Yu Sasaki, Kazuhiro Nishiyama, Hokahiro Katayama, Nobuko Ogura, Shoji Tsunekawa, Yoshiro Taki, Mizuho Akahane, Teruyoshi Aoyama, Hiroko Matsumoto, Shoji Takami, Jun Kawai
A woman in her 50s was admitted to our hospital with fever and lower abdominal swelling. Abdominal CT/MRI examinations revealed irregular thickening of the transverse colon wall, which was attached to a subcutaneous abscess. An abdominal wall mass, a patent urachus, and a tumor in the 5th segment of the liver were also noted. Colonoscopy revealed type 2 advanced transverse colon cancer. The solitary, sessile tumor was observed at the apex of the bladder under cystoscopy, suggesting the formation of the urachal carcinoma...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650505/universal-versus-conditional-third-day-follow-up-visit-for-children-with-nonsevere-unclassified-fever-at-the-community-level-in-ethiopia-protocol-for-a-cluster-randomized-noninferiority-trial
#15
Karin Källander, Tobias Alfven, Ayalkibet Abebe Workineh, Abreham Hailemariam, Max Petzold, Dawit Getachew, Lawrence Barat, Laura C Steinhardt, Julie R Gutman
BACKGROUND: Under the World Health Organization's integrated community case management strategy, febrile children seen by community health workers (on day 1) without a diagnosable illness and without danger signs are advised to return on day 3, regardless of symptom resolution. This advice might be unnecessary and place additional time and cost burdens on caregivers and community health workers. However, the safety of not following up with respect to children with unclassified fever is unknown...
April 12, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29648910/usefulness-of-positron-emission-tomography-ct-for-diagnosis-of-primary-bone-marrow-lymphoma-in-children
#16
Kyoko Moritani, Naoko Nakano, Sachiko Yonezawa, Fumihiro Ochi, Hisamichi Tauchi, Minenori Eguchi-Ishimae, Mariko Eguchi, Eiichi Ishii, Kozo Nagai
Primary bone marrow lymphoma (PBML) is hard to diagnose in children, due to the difficult identification of malignant cells in bone marrow. The first case, a 5-year-old boy, showed knee swelling with an intermittent fever. The second case, a 12-year-old girl, showed fever of unknown origin without lymphadenopathy or hepatosplenomegaly. In both cases, the diagnosis was not confirmed despite the repeated bone marrow aspirations. Finally, bone marrow aspiration and biopsy at the positive site by positron emission tomography (PET)-CT contributed to definitive diagnosis of PBML...
April 12, 2018: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29642989/cardiogenic-causes-of-fever
#17
Jan Smid, Maximilian Scherner, Oliver Wolfram, Thomas Groscheck, Jens Wippermann, Rüdiger C Braun-Dullaeus
BACKGROUND: Persistent fever of unknown cause is only rarely of cardiac origin, but heart disease must be considered in the differential diagnosis. Aside from endocarditis, pericarditis and various other conditions may be responsible. METHODS: This review is based on pertinent articles retrieved by a selective search in PubMed and Google Scholar employing the term "fever" in combination with "myocardial infarction," "pericarditis," "endocarditis," and "postcardiac injury," with additional consideration of current cardiological guidelines...
March 23, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29642928/diagnostic-and-management-of-life-threatening-adult-onset-still-disease-a-french-nationwide-multicenter-study-and-systematic-literature-review
#18
Antoine Néel, Anaïs Wahbi, Benoit Tessoulin, Julien Boileau, Dorothée Carpentier, Olivier Decaux, Laurence Fardet, Guillaume Geri, Pascal Godmer, Cécile Goujard, Hervé Maisonneuve, Arnaud Mari, Jacques Pouchot, Jean-Marc Ziza, Cédric Bretonnière, Mohamed Hamidou
BACKGROUND: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disorder. A few patients develop organ complications that can be life-threatening. Our objectives were to describe the disease course and phenotype of life-threatening AOSD, including response to therapy and long-term outcome. METHODS: A multicenter case series of intensive care medicine (ICU) patients with life-threatening AOSD and a systematic literature review. RESULTS: Twenty patients were included...
April 11, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29624096/interleukin-6-producing-pheochromocytoma-as-a-new-reason-for-fever-of-unknown-origin-a-retrospective-study
#19
Xiangming Cheng, Mingxin Zhang, Yu Xiao, Hanzhong Li, Yushi Zhang, Zhigang Ji
OBJECTIVE: To explore the fever of unknown origin (FUO) resulted by Interleukin-6 (IL-6) producing pheochromocytoma. MATERIAL AND METHODS: Patients with pheochromocytoma were gathered from June 2014 to April 2017. The clinical characteristics of patients were recorded such as gender, age, 24hr urinary catecholamines (norepinephrine, epinephrine, dopamine), tumor size, axillary temperature (AT), white blood cells (WBC), serum IL-6 level and high sensitive C Reactive Protein (hsCRP)...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29620719/preoperative-illnesses-in-children-do-not-increase-the-risk-of-complications-after-hypospadias-repair
#20
Elisabeth Mj Dokter, Karen Ma Slikboer, Loes Fm van der Zanden, Janette C Rahamat-Langendoen, Stefanie Sv Henriet, Wout Fj Feitz, Barbara Bm Kortmann, Nel Roeleveld, Iris Alm van Rooij
BACKGROUND: Preoperative illnesses might induce immunosuppression and subsequently increase morbidity after surgery. Several studies have tried to identify risk factors for complications after hypospadias correction, but effects of illnesses in the weeks just before surgery are unknown. We aimed to determine the associations between preoperative illnesses not severe enough to postpone surgery and short-term complications after hypospadias repair in children. METHODS: In this retrospective cohort study, data were collected from 681 children with anterior or middle type hypospadias that had initial one-stage repair in the period 1983-2012 in the Radboudumc, The Netherlands...
March 31, 2018: Pediatric Infectious Disease Journal
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