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https://www.readbyqxmd.com/read/28820703/assessment-of-u-s-pediatrician-knowledge-of-toxocariasis
#1
Dana M Woodhall, Amanda P Garcia, Craig A Shapiro, Shequenta L Wray, Andi L Shane, Chitra S Mani, Kelly K Stimpert, LeAnne M Fox, Susan P Montgomery
Toxocariasis, one of a group of parasitic diseases known as neglected parasitic infections, is a disease caused by the larvae of two species of Toxocara roundworms, Toxocara canis, from dogs, and less commonly Toxocara cati, from cats. Although most infected individuals are asymptomatic, clinical manifestations may include fever, fatigue, coughing, wheezing, or abdominal pain (visceral toxocariasis) or vision loss, retina damage, or eye inflammation (ocular toxocariasis). To assess U.S. pediatrician knowledge of toxocariasis, we conducted an electronic survey of American Academy of Pediatrics members...
July 31, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28820686/the-emergence-of-severe-fever-with-thrombocytopenia-syndrome-virus
#2
Jesus A Silvas, Patricia V Aguilar
Severe fever with thrombocytopenia syndrome (SFTS) is a newly recognized hemorrhagic fever disease found throughout Asia with a case fatality rate between 12% and 30%. Since 2009, SFTS has been reported in China throughout 14 Chinese Provinces. In addition, SFTS has been recognized in South Korea and Japan with the first confirmed cases reported in 2012. A similar disease, caused by the closely related Heartland virus, was also reported in the United States in 2009. SFTS is caused by SFTS virus, a novel tick-borne virus in the family Bunyaviridae, genus Phlebovirus...
August 7, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28814592/fever-and-generalised-lymphadenopathy-in-an-hiv-positive-patient-a-diagnostic-challenge
#3
Bernardo Neves, Pedro Raimundo, Pedro Farinha
Fever and generalised lymphadenopathy is a common presentation of a variety of diseases and a thorough investigation is often necessary for appropriate diagnosis.We present a 53-year-old male patient admitted with fever, weight loss of 15 kg in 3 months and abdominal discomfort. Examination was only remarkable for axillary and inguinal lymphadenopathy. Blood tests showed normocytic normochromic anaemia, cholestasis and a previously unknown HIV-1 infection with lymphocyte CD4 +count of 239 cells/mm(3) and viral load 3...
August 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28811951/granulomatosis-with-polyangiitis-presenting-as-pyrexia-of-unknown-origin-leukocytosis-and-microangiopathic-haemolytic-anemia
#4
Sima Terebelo, Iona Chen
A 66-year-old woman presented to the Emergency Department with a florid sepsis-like picture, a two-week history of fever, relative hypotension with end organ ischemia (unexplained liver enzyme and troponin elevations), and nonspecific constitutional symptoms. She was initially found to have a urinary tract infection but, despite appropriate treatment, her fever persisted and her white blood cell count continued to rise. During her hospitalization the patient manifested leukocytosis to 47,000 WBC/μL, ESR 67 mm/hr (normal range 0-42 mm/hr), CRP 17...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28811340/type-iii-interferon-mediated-signaling-is-critical-for-controlling-live-attenuated-yellow-fever-virus-infection-in-vivo
#5
Florian Douam, Yentli E Soto Albrecht, Gabriela Hrebikova, Evita Sadimin, Christian Davidson, Sergei V Kotenko, Alexander Ploss
Yellow fever virus (YFV) is an arthropod-borne flavivirus, infecting ~200,000 people worldwide annually and causing about 30,000 deaths. The live attenuated vaccine strain, YFV-17D, has significantly contributed in controlling the global burden of yellow fever worldwide. However, the viral and host contributions to YFV-17D attenuation remain elusive. Type I interferon (IFN-α/β) signaling and type II interferon (IFN-γ) signaling have been shown to be mutually supportive in controlling YFV-17D infection despite distinct mechanisms of action in viral infection...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28810044/swept-source-optical-coherence-tomography-angiography-in-west-nile-virus-chorioretinitis-and-associated-occlusive-retinal-vasculitis
#6
Moncef Khairallah, Rim Kahloun, Salma Gargouri, Bechir Jelliti, Dorra Sellami, Salim Ben Yahia, Jamel Feki
A 65-year-old man with diabetes and a history of fever of unknown origin 2 weeks earlier complained of sudden decreased vision in the left eye. The patient was diagnosed with bilateral West Nile virus (WNV) chorioretinitis associated with occlusive retinal vasculitis in the left eye. Swept-source optical coherence tomography angiography (SS-OCTA) of the left eye showed extensive, well-delineated, hypointense non-perfusion areas and perifoveal capillary arcade disruption in the superficial capillary plexus, as well as larger non-perfusion areas, capillary rarefaction, and diffuse capillary network attenuation and disorganization in the deep capillary plexus...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28806976/quantitative-detection-of-human-malawi-polyomavirus-in-nasopharyngeal-aspirates-sera-and-feces-in-beijing-china-using-real-time-taqman-based-pcr
#7
Fen-Lian Ma, Dan-di Li, Tian-Li Wei, Jin-Song Li, Li-Shu Zheng
BACKGROUND: Human Malawi polyomavirus (MWPyV) was discovered in 2012, but its prevalence and clinical characteristics are largely unknown. METHODS: We used real-time TaqMan-based PCR to detect MWPyV in the feces (n = 174) of children with diarrhea, nasopharyngeal aspirates (n = 887) from children with respiratory infections, and sera (n = 200) from healthy adults, and analyzed its clinical characteristics statistically. All the MWPyV-positive specimens were also screened for other common respiratory viruses...
August 14, 2017: Virology Journal
https://www.readbyqxmd.com/read/28806629/aseptic-meningitis-in-adults-and-children-diagnostic-and-management-challenges
#8
Bhavarth Shukla, Elizabeth A Aguilera, Lucrecia Salazar, Susan H Wootton, Quanhathai Kaewpoowat, Rodrigo Hasbun
BACKGROUND: Aseptic meningitis represents a common diagnostic and management dilemma to clinicians. OBJECTIVES: To compare the clinical epidemiology, diagnostic evaluations, management, and outcomes between adults and children with aseptic meningitis. STUDY DESIGN: We conducted a retrospective study from January 2005 through September 2010 at 9 Memorial Hermann Hospitals in Houston, TX. Patients age≥2months who presented with community-acquired aseptic meningitis with a CSF white blood cell count >5cells/mm(3) and a negative Gram stain and cultures were enrolled...
August 4, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28806242/generalized-lymph-node-fdg-uptake-as-the-first-manifestation-of-systemic-lupus-erythematosus
#9
Antoine Girard, Jessica Ohnona, Jean-François Bernaudin, Françoise Montravers, Claude Bachmeyer
We report 2 cases of young patients referred for FDG PET/CT for peripheral lymphadenopathy and moderate fever associated with pericarditis in 1 patient and glomerulonephritis in the other patient. FDG PET/CT showed a very similar appearance in these 2 patients, with highly avid lymph nodes with axillary predominance and diffuse FDG uptake in spleen and bone marrow. Systemic lupus erythematosus with an unusual presentation of generalized lymphadenopathy was diagnosed in both patients. This FDG distribution pattern should be kept in mind when PET is performed for etiological investigation of fever of unknown origin...
August 12, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28806027/a-rare-case-of-lymphadenopathy-kikuchi-fujimoto-disease
#10
Josh Rezkalla, Douglas W Lynch
A relatively unknown cause of cervical lymphadenopathy is Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis. This is a rare and benign condition that presents with painful cervical lymphadenopathy, fevers, night sweats, and weight loss. This disease is most prevalent in Asian women between the age of 20-35 years. The diagnosis of Kikuchi Disease is made histologically and is characterized by paracortical areas of necrosis and a notable complete absence of neutrophils. The painful lymphadenopathy can be simply treated with antipyretics, but due to its presenting symptoms of Kikuchi disease, it is often mistaken for malignant lymphoma...
July 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28796786/phlebotomine-sand-fly-borne-pathogens-in-the-mediterranean-basin-human-leishmaniasis-and-phlebovirus-infections
#11
REVIEW
Martina Moriconi, Gianluca Rugna, Mattia Calzolari, Romeo Bellini, Alessandro Albieri, Paola Angelini, Roberto Cagarelli, Maria P Landini, Remi N Charrel, Stefania Varani
Pathogens transmitted to humans by phlebotomine sand flies are neglected, as they cause infectious diseases that are not on the priority list of national and international public health systems. However, the infections caused by protozoa of the Leishmania genus and viruses belonging to the Phlebovirus genus (family Phenuiviridae)-the most significant group of viruses transmitted by sand flies-have a relevant role for human pathology. These infections are emerging in the Mediterranean region and will likely spread in forthcoming decades, posing a complex threat to human health...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28794491/ebola-virus-vp24-interacts-with-np-to-facilitate-nucleocapsid-assembly-and-genome-packaging
#12
Logan Banadyga, Thomas Hoenen, Xavier Ambroggio, Eric Dunham, Allison Groseth, Hideki Ebihara
Ebola virus causes devastating hemorrhagic fever outbreaks for which no approved therapeutic exists. The viral nucleocapsid, which is minimally composed of the proteins NP, VP35, and VP24, represents an attractive target for drug development; however, the molecular determinants that govern the interactions and functions of these three proteins are still unknown. Through a series of mutational analyses, in combination with biochemical and bioinformatics approaches, we identified a region on VP24 that was critical for its interaction with NP...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28782604/first-serological-evidence-of-crimean-congo-haemorrhagic-fever-in-febrile-patients-in-mozambique
#13
Argentina Felisbela Muianga, Robert Watson, Anitha Varghese, Inocencio Salvador Chongo, Sadia Ali, Vanessa Monteiro, Flora Inalda, Imelda Chelene, Virgilio António, Roger Hewson, Eduardo Samo Gudo
OBJECTIVE: Despite its geographical spread, the epidemiology of Crimean-Congo haemorrhagic fever (CCHF) in Sub-Saharan Africa is incompletely understood and its occurrence in Mozambique is unknown. This study was conducted with the aim of investigating the occurrence of CCHF virus (CCHFV) among febrile patients attending an outpatient appointment clinic at three separate primary health care centres in Mozambique. METHODS: Serum samples were collected from a total of 300 febrile patients aged >5 years who were recruited between March 2015 and March 2016 at three health centres in Mozambique...
August 3, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28782352/cornus-mas-a-review-on-traditional-uses-and-pharmacological-properties
#14
Fatemeh Hosseinpour-Jaghdani, Tahoora Shomali, Sajedeh Gholipour-Shahraki, Mohammad Rahimi-Madiseh, Mahmoud Rafieian-Kopaei
Medicinal plants that are used today have been known by people of ancient cultures around the world and have largely been considered due to their medicinal properties. Cornus mas L. (Cornelian cherry) is one of these medicinal plants with high level of antioxidant activity. Cornelian cherry is an attractive ornamental plant with delicious fruit having nutritional and therapeutic values. The main purpose of this paper is to present and summarize the pharmacological and therapeutic effects from researches done on Cornelian cherry in studies from 2000 to 2016...
March 31, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28782120/cases-of-transfusion-transmitted-babesiosis-occurring-in-nonendemic-areas-a-diagnostic-dilemma
#15
David P LeBel, Erin D Moritz, Jennifer J O'Brien, John Lazarchick, Lee Marie Tormos, Angie Duong, Magali J Fontaine, Jerry E Squires, Susan L Stramer
BACKGROUND: Transfusion-transmitted babesiosis (TTB) has been rapidly increasing in incidence since the beginning of the 21st century. Asymptomatic individuals with Babesia infection are able to donate blood in the United States because of the lack of specific blood donation testing. Blood products collected in Babesia-endemic areas are distributed nationally; thus, clinicians in nonendemic states may fail to include babesiosis in the differential diagnosis of a patient who had a recent transfusion history and a fever of unknown origin...
August 7, 2017: Transfusion
https://www.readbyqxmd.com/read/28770976/non-steroidal-anti-inflammatory-drugs-nsaids-for-chronic-non-cancer-pain-in-children-and-adolescents
#16
REVIEW
Christopher Eccleston, Tess E Cooper, Emma Fisher, Brian Anderson, Nick Mr Wilkinson
BACKGROUND: Pain is a common feature of childhood and adolescence around the world, and for many young people, that pain is chronic. The World Health Organization guidelines for pharmacological treatments for children's persisting pain acknowledge that pain in children is a major public health concern of high significance in most parts of the world. While in the past pain was largely dismissed and was frequently left untreated, views on children's pain have changed over time, and relief of pain is now seen as important...
August 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28768542/early-rigorous-control-interventions-can-largely-reduce-dengue-outbreak-magnitude-experience-from-chaozhou-china
#17
Tao Liu, Guanghu Zhu, Jianfeng He, Tie Song, Meng Zhang, Hualiang Lin, Jianpeng Xiao, Weilin Zeng, Xing Li, Zhihao Li, Runsheng Xie, Haojie Zhong, Xiaocheng Wu, Wenbiao Hu, Yonghui Zhang, Wenjun Ma
BACKGROUND: Dengue fever is a severe public heath challenge in south China. A dengue outbreak was reported in Chaozhou city, China in 2015. Intensified interventions were implemented by the government to control the epidemic. However, it is still unknown the degree to which intensified control measures reduced the size of the epidemics, and when should such measures be initiated to reduce the risk of large dengue outbreaks developing? METHODS: We selected Xiangqiao district as study setting because the majority of the indigenous cases (90...
August 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28768449/recurrent-fuo-due-to-intermittent-enterobacter-cloacae-bacteremias-from-an-infected-pacemaker-lead-diagnosed-by-gallium-scan
#18
Burke A Cunha, Ismail Jimada
Fever of unknown origin (FUO) refers to fevers of ≥101° F that persist for ≥3 weeks and remain undiagnosed after a focused inpatient or outpatient workup. FUO may be due to infectious, malignant/neoplastic, rheumatic/inflammatory, or miscellaneous disorders. Recurrent FUOs are due to the same causes of classical FUOs. Recurrent FUOs may have continuous or intermittent fevers and are particularly difficult to diagnose. With intermittent fever, recurrent FUO diagnostic tests are best obtained during fever episodes...
August 2, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28768255/acne-fulminans-treatment-experience-from-26-patients
#19
António F Massa, Lena Burmeister, Dirk Bass, Christos C Zouboulis
Background /Aim: Acne fulminans is a rare form of acne vulgaris with acute clinical deterioration including systemic signs. Etiopathogenesis and management remain largely unknown. Our aim is to assess the efficacy of a combined therapeutic regimen of systemic isotretinoin and prednisolone following the recent concepts of acne pathogenesis and drug kinetics. METHODS: A prospective case series was recruited over 15 years. Isotretinoin 0.5 mg/kg bw/d (0.25-0-0.25) and prednisolone 30 mg/d (10-10-10) were administered concomitantly with prednisolone being tapered after that time...
July 29, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28767581/diagnostic-value-of-pet-ct-for-giant-cell-arteritis-combined-with-pulmonary-embolism-presenting-case-report-and-literature-review
#20
Xiaoming Shu, Xiaoxiang Xu, Qinglin Peng, Xin Lu, Li Ma, Na Mi, Guochun Wang
RATIONALE: Giant cell arteritis (GCA) combined with concomitant pulmonary embolism (PE) is extremely difficult to diagnose because of its low incidence and atypical clinical presentations. PATIENT CONCERNS: A 62-year-old male developed fever of unknown origin. DIAGNOSES: Positron emission tomography/computed tomography (PET/CT) revealed increased glucose metabolism in the vascular walls of the ascending and descending aorta and pulmonary artery, leading to a diagnosis of GCA combined with PE...
August 2017: Medicine (Baltimore)
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