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pregnancy and pancreatitis

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https://www.readbyqxmd.com/read/29352600/placental-control-of-metabolic-adaptations-in-the-mother-for-an-optimal-pregnancy-outcome-what-goes-wrong-in-gestational-diabetes
#1
David J Hill
As pregnancy progresses the placental syncytiotrophoblast increasingly assumes control of maternal glucose homeostasis through the release and counter-balancing effects of placental lactogen (PL) and placental variant growth hormone (GH-V). While local actions of these hormones on placental growth and function are likely to exist, each also exerts indirect actions to ensure fetal nutritional availability through modulation of the maternal insulin/insulin-like growth factor axis. Peripheral insulin resistance results from the increasing levels of GH-V in the maternal circulation and is counter-balanced by an increase in insulin availability through an expansion of maternal pancreatic β-cell mass...
January 9, 2018: Placenta
https://www.readbyqxmd.com/read/29349553/differential-jnk-p38-and-erk-response-to-renal-injury-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#2
Fangchao Mei, Teng Zuo, Liang Zhao, Qiao Shi, Mingwei Xiang, Yupu Hong, Man Li, Weixing Wang
OBJECTIVE: The objective of this study was to determine the mechanism of acute renal injury (ARI) in acute necrotizing pancreatitis in late pregnancy (ANPIP). METHODS: Pregnant Sprague-Dawley rats in the third trimester were used for this study, and an ANPIP model was induced by injecting 5% sodium taurocholate into the biliary pancreatic duct. The rats were randomly divided into three groups: the normal, sham-operated (SO) and acute necrotizing pancreatitis (ANP) groups...
January 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29346712/synergetic-effects-of-prenatal-and-postnatal-high-sucrose-intake-on-glucose-tolerance-and-hepatic-insulin-resistance-in-rat-offspring
#3
Pengjie Zhang, Di Zhu, Yueming Zhang, Lingjun Li, Xionghui Chen, Wenna Zhang, Ruixiu Shi, Jianying Tao, Bing Han, Zhice Xu
SCOPE: High sucrose intake during pregnancy is linked to type 2 diabetes mellitus and altered insulin resistance. METHODS AND RESULTS: This study attempted to ascertain whether prenatal high sucrose intake (20% sucrose) alleviates the detrimental effects of high postnatal sugar consumption in the offspring, and the molecular mechanisms were investigated using a rat model. High prenatal sucrose exposure increased the body weight of the offspring at 1 to 3 weeks of age...
January 18, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29284078/hepatobiliary-and-pancreatic-pregnancy-induced-hepatic-veno-occlusive-disease-requiring-liver-transplantation
#4
N Harimoto, K Yugawa, T Ikegami, M Ohira, Y Mano, T Motomura, T Toshima, S Itoh, N Harada, Y Soejima, T Yoshizumi, Y Maehara, Y Oda
No abstract text is available yet for this article.
January 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29259351/pregnancy-with-concomitant-pancreatic-cancer
#5
Öner Aynıoğlu, Rahime Nida Ergin, Yig It Çakırog Lu, Eray Çalışkan
We report a rare case of pregnancy with concomitant pancreatic cancer. At 28 weeks' gestation, the patient was diagnosed with a large tumoral mass in the head of the pancreas. She had a cesarean section at 32 weeks' gestation due to premature labor and underwent surgery for pancreatic cancer in her third month postpartum.
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29241388/hypercalcemia-induced-pancreatitis-in-pregnancy-following-calcium-carbonate-ingestion
#6
May S Trezevant, John C Winton, Ashley K Holmes
BACKGROUND: Calcium carbonate is often used to relieve Gastroesophageal Reflux Disease (GERD) in pregnant patients. This report describes a potentially serious complication. CASE: A pregnant female presented at 34 weeks gestation with abdominal pain, nausea, and vomiting. Home medications included an unquantifiable amount of calcium carbonate 500 mg due to constant consumption for GERD. Laboratory findings included elevated calcium, amylase, lipase, and triglyceride level...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/29235528/identification-of-newly-committed-pancreatic-cells-in-the-adult-mouse-pancreas
#7
Mairobys Socorro, Angela Criscimanna, Patricia Riva, Manuj Tandon, Krishna Prasadan, Ping Guo, Abhinav Humar, Sohail Z Husain, Steven D Leach, George K Gittes, Farzad Esni
Multipotent epithelial cells with high Aldehyde dehydrogenase activity have been previously reported to exist in the adult pancreas. However, whether they represent true progenitor cells remains controversial. In this study, we isolated and characterized cells with ALDH activity in the adult mouse or human pancreas during physiological conditions or injury. We found that cells with ALDH activity are abundant in the mouse pancreas during early postnatal growth, pregnancy, and in mouse models of pancreatitis and type 1 diabetes (T1D)...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29227009/fetal-liver-injury-ameliorated-by-migration-inhibitory-factor-inhibition-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#8
Zheng-Da Guo, Liang Zhao, Peng Wang, Wen-Hong Deng, Qiao Shi, Teng Zuo, Yu-Pu Hong, Wei-Xing Wang
AIM: This study was designed to investigate and assess fetal liver injury in a rat model of acute pancreatitis in pregnancy (APIP) as well as its possible mechanisms and potential therapeutic targets. METHODS: The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. ISO-1, a macrophage migration inhibitory factor (MIF) antagonist, was given before the induction of APIP. In addition, sham-operated rats at later gestation were set as controls...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29209605/the-effect-of-cigarette-smoking-during-pregnancy-on-endocrine-pancreatic-function-and-fetal-growth-a-pilot-study
#9
Fatima Lockhart, Anthony Liu, Bernard Linton Champion, Michael John Peek, Ralph Kay Heinrich Nanan, Alison Sally Poulton
Introduction: Cigarette smoking in pregnancy is a common cause of fetal growth restriction. We aimed to investigate endocrine pancreatic function of mother-infant dyads in relation to cigarette smoking, as a possible mechanism for the poor fetal growth. Methods: Prospective study of smoking mothers (10 cigarettes or more per day, self-reported to the midwife) and non-smoker control mothers during their first pregnancy. Insulin, glucose, C-peptide, HbA1C, fructosamine, prolactin, serotonin, and cortisol were measured in maternal blood at 24-26 weeks and in umbilical cord blood at birth...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29192743/can-pancreatic-cancer-be-detected-by-adrenomedullin-in-patients-with-new-onset-diabetes-the-pacanod-cohort-study-protocol
#10
Laura Antolino, Mara La Rocca, Federico Todde, Elena Catarinozzi, Paolo Aurello, Lucilla Bollanti, Giovanni Ramacciato, Francesco D'Angelo
INTRODUCTION: Pancreatic cancer is a leading cause of cancer-related death. Its diagnosis is often delayed and patients are frequently found to have unresectable disease. Patients diagnosed with new-onset diabetes have an 8-fold risk of harboring pancreatic cancer. Adrenomedullin has been claimed to mediate diabetes in pancreatic cancer. New screening tools are needed to develop an early diagnosis protocol. METHODS: Patients aged 45-75 years within 2 years of first fulfilling the ADA criteria for diabetes will be prospectively enrolled in this study...
November 29, 2017: Tumori
https://www.readbyqxmd.com/read/29170800/early-life-origin-of-type-1-diabetes
#11
REVIEW
Mikael Knip, Kristiina Luopajärvi, Taina Härkönen
Type 1 diabetes (T1D) is perceived as a chronic immune-mediated disease with a subclinical prodromal period characterized by selective loss of insulin-producing beta cells in the pancreatic islets in genetically susceptible subjects. The incidence of T1D has increased manifold in most developed countries after World War II in parallel with a series of other immune-mediated diseases. T1D results from gene-environmental interactions. The appearance of disease-associated autoantibodies into the peripheral circulation is the first detectable sign of the initiation of the disease process leading to clinical T1D...
November 23, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/29164335/clinical-characteristics-of-acute-pancreatitis-in-pregnancy-experience-based-on-121-cases
#12
Lingyu Luo, Hao Zen, Hongrong Xu, Yin Zhu, Pi Liu, Liang Xia, Wenhua He, Nonghua Lv
PURPOSE: Acute pancreatitis in pregnancy (APIP) is a rare condition; however, it markedly affects maternal and fetal health. This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP). METHODS: We retrospectively reviewed 121 APIP cases in the Gastroenterology Department of The First Affiliated Hospital of Nanchang University. APIP diagnosis were based on 2012 Atlanta Criteria...
November 21, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29157116/perinatal-exposure-to-high-dietary-advanced-glycation-end-products-in-transgenic-nod8-3-mice-leads-to-pancreatic-beta-cell-dysfunction
#13
Danielle J Borg, Felicia Y T Yap, Sahar Keshvari, David G Simmons, Linda A Gallo, Amelia K Fotheringham, Aowen Zhuang, Robyn M Slattery, Sumaira Z Hasnain, Melinda T Coughlan, Phillip Kantharidis, Josephine M Forbes
The contribution of environmental factors to pancreatic islet damage in type 1 diabetes remains poorly understood. In this study, we crossed mice susceptible to type 1 diabetes, where parental male (CD8(+) T cells specific for IGRP206-214; NOD8.3) and female (NOD/ShiLt) mice were randomized to a diet either low or high in AGE content and maintained on this diet throughout pregnancy and lactation. After weaning, NOD8.3(+) female offspring were identified and maintained on the same parental feeding regimen for until day 28 of life...
November 20, 2017: Islets
https://www.readbyqxmd.com/read/29147113/clinical-presentation-management-and-outcomes-of-primary-hyperparathyroidism-during-pregnancy
#14
Ya Hu, Ming Cui, Zhengyi Sun, Zhe Su, Xiang Gao, Quan Liao, Yupei Zhao
Background: Primary hyperparathyroidism (pHPT) in pregnancy is a rare event, but it poses a significant risk to mothers and fetuses. The optimal treatment strategy remains controversial. Methods: We present a consecutive series of twelve pregnant women with pHPT. Results: Twelve women were diagnosed with pHPT during pregnancy or in the postpartum period. Four of them presented no symptoms or mild symptoms. Four patients experienced serious complications, including hypercalcaemic crisis, acute pancreatitis, and eclampsia...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29143222/quantitative-analysis-of-the-level-of-readability-of-online-emergency-radiology-based-patient-education-resources
#15
David R Hansberry, Michael D'Angelo, Michael D White, Arpan V Prabhu, Mougnyan Cox, Nitin Agarwal, Sandeep Deshmukh
PURPOSE: The vast amount of information found on the internet, combined with its accessibility, makes it a widely utilized resource for Americans to find information pertaining to medical information. The field of radiology is no exception. In this paper, we assess the readability level of websites pertaining specifically to emergency radiology. METHODS: Using Google, 23 terms were searched, and the top 10 results were recorded. Each link was evaluated for its readability level using a set of ten reputable readability scales...
November 15, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/29113123/high-neonatal-blood-iron-content-is-associated-with-the-risk-of-childhood-type-1-diabetes-mellitus
#16
Julie Nyholm Kyvsgaard, Anne Julie Overgaard, Steffen Ullitz Thorsen, Thomas Hesselhøj Hansen, Christian Bressen Pipper, Henrik Bindesbøl Mortensen, Flemming Pociot, Jannet Svensson
(1) Background: Iron requirement increases during pregnancy and iron supplementation is therefore recommended in many countries. However, excessive iron intake may lead to destruction of pancreatic β-cells. Therefore, we aim to test if higher neonatal iron content in blood is associated with the risk of developing type 1 diabetes mellitus (T1D) in childhood; (2) Methods: A case-control study was conducted, including 199 children diagnosed with T1D before the age of 16 years from 1991 to 2005 and 199 controls matched on date of birth...
November 6, 2017: Nutrients
https://www.readbyqxmd.com/read/29111856/vascular-derived-connective-tissue-growth-factor-ctgf-is-critical-for-pregnancy-induced-%C3%AE-cell-hyperplasia-in-adult-mice
#17
Raymond C Pasek, Jennifer C Dunn, Joseph M Elsakr, Mounika Aramandla, Anveetha R Matta, Maureen Gannon
During pregnancy, maternal β cells undergo compensatory changes including hypertrophy, hyperplasia, and increased glucose-stimulated insulin secretion (GSIS). Failure of these adaptations to occur can result in gestational diabetes mellitus. The secreted protein, Connective tissue growth factor (Ctgf), is critical for normal β cell development and promotes regeneration after partial β cell ablation. During embryogenesis, Ctgf is expressed in pancreatic ducts, vasculature, and β cells. In the adult pancreas, Ctgf is expressed only in the vasculature...
November 7, 2017: Islets
https://www.readbyqxmd.com/read/29098391/fetal-sex-influences-maternal-fasting-plasma-glucose-levels-and-basal-%C3%AE-cell-function-in-pregnant-women-with-normal-glucose-tolerance
#18
Xinqian Geng, Lulu Geng, Yinan Zhang, Huijuan Lu, Yixie Shen, Ruihua Chen, Pingyan Fang, Minfang Tao, Congrong Wang, Weiping Jia
AIMS: Fetal sex has recently emerged as a new factor that is related to maternal glucose homeostasis during pregnancy. The present study aimed to investigate the effect of fetal sex on maternal glucose metabolism in women with normal glucose tolerance (NGT) during pregnancy in the Chinese population. METHODS: A total of 877 pregnant women with NGT were recruited at 24-28 weeks of gestation and underwent a 75-g oral glucose tolerance test (OGTT). Pregnant women were divided into two groups according to fetal sex...
November 2, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29097511/precision-medicine-in-obesity-and-type-2-diabetes-the-relevance-of-early-life-exposures
#19
REVIEW
Angela C Estampador, Paul W Franks
BACKGROUND: Type 2 diabetes is highly prevalent and devastating. Obesity is a diabetogenic factor, driving insulin resistance and a compensatory demand for increased insulin secretion from the pancreatic β cells; a failure to address this demand results in diabetes. Accordingly, primary and secondary prevention of obesity are at the core of diabetes prevention programs. The development of obesity and decline in β-cell function often span many years or decades before diabetes is clinically manifest...
November 2, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29041829/characteristics-and-outcome-of-severe-preeclampsia-eclampsia-concurrent-with-or-complicated-by-acute-pancreatitis-a-report-of-five-cases-and-literature-review
#20
Cuiqin Sang, Shuzhen Wang, Zhenyu Zhang, Junli Lu
OBJECTIVE: The objective of this study is to determine the rate of acute pancreatitis in preeclampsia/eclampsia patients and describe the clinical manifestations, treatment characteristics and outcome of five cases of severe preeclampsia concurrent with or complicated by acute pancreatitis. METHODS: The clinical data of pregnant women with preexisting or gestational hypertension who sought medical care between January 2002 and December 2015 at the Pregnant Women Critical Care Unit of Chaoyang Hospital, Capital Medical University, Beijing, China were retrieved...
October 17, 2017: Journal of Maternal-fetal & Neonatal Medicine
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