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https://www.readbyqxmd.com/read/29925744/effect-of-lipoprotein-associated-phospholipase-a2-inhibitor-on-insulin-resistance-in-streptozotocin-induced-diabetic-pregnant-rats
#1
Guo-Hua Wang, Jun Jin, Li-Zhou Sun
This paper aims to investigate the influence of lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, darapladib, on insulin resistance (IR) in streptozotocin (STZ)-induced diabetic pregnant rats. The rat models were divided into Control (normal pregnancy), STZ + saline (STZ-induced diabetic pregnant rats), STZ + Low-dose and STZ + High-dose darapladib (STZ-induced diabetic pregnant rats treated with low-/high-dose darapladib) groups. Pathological changes were observed by Hematoxylin-eosin (HE) and Immunohistochemistry staining...
June 21, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29903238/-effects-of-high-sucrose-high-fat-diet-feeding-time-on-establishment-of-a-mouse-model-of-gestational-diabetes-mellitus
#2
Jiacui Ren, Ye Ding, Lu Yin, Rui Qin, Yuanhong She, Jin Xu, Zhixu Wang
OBJECTIVE: The present study focuses on the effects of different highsucrose/high-fat diet feeding time on body weight, glucose and lipid metabolism parameters and pathological changes of pancreas and liver in pregnant mice. METHODS: Female C57 BL/6 J mice were divided into three groups randomly: normal control group( C) and two different high-sucrose/high-fat diet feeding time groups( H1 and H2). Body weight, food and energy intakes and blood glucose were measured at multiple time points before and during pregnancy...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29895203/pregnancy-after-whipple-procedure-a-new-case-and-review-of-the-literature
#3
Giulia Magoga, Laura Felder, Francesco Palazzo, Vincenzo Berghella
BACKGROUND: Whipple procedure is a complex operation usually performed to treat periampullary neoplasms. There are only four case reports of five pregnancies after Whipple procedure, with limited evidence about how to manage pregnancy after this surgery. CASE: A 28-year-old gravida 5 Para 2022 presented to our hospital at 20 weeks with worsening depression. She had a history of Whipple for a solid pseudopapillary neoplasm of the pancreas followed by two pregnancies...
June 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29891438/sex-differences-underlying-pancreatic-islet-biology-and-its-dysfunction
#4
REVIEW
Maureen Gannon, Rohit N Kulkarni, Hubert M Tse, Franck Mauvais-Jarvis
BACKGROUND: The sex of an individual affects glucose homeostasis and the pathophysiology, incidence, and prevalence of diabetes as well as the response to therapy. SCOPE OF THE REVIEW: This review focuses on clinical and experimental sex differences in islet cell biology and dysfunction during development and in adulthood in human and animal models. We discuss sex differences in β-cell and α-cell function, heterogeneity, and dysfunction. We cover sex differences in communication between gonads and islets and islet-cell immune interactions...
May 30, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29886492/pancreatic-cancer-in-pregnancy-presenting-with-thromboembolic-events-case-report-and-review-of-the-literature
#5
Brian W Wakefield, Crystal M C Masterson, Manuel T Borges, K Joseph Hurt
Stroke and hepatic vein thrombosis are highly associated with neoplasia but are extremely rare events in young, pregnant women. Rare and recurrent thrombotic events in pregnancy increase the suspicion for occult malignancy. We describe the case of a healthy 31-year-old G2P1 who presented with visual changes and dysarthria during pregnancy. Imaging showed cerebral infarcts. Her thrombophilia evaluation was negative. During delivery, she was diagnosed with fulminant Budd-Chiari Syndrome. Hepatic ultrasound suggested malignancy or metastasis, and postpartum CT scan and biopsy confirmed the diagnosis of Stage IV pancreatic cancer...
June 8, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29850316/management-of-a-pregnancy-with-a-solid-pseudopapillary-neoplasm-of-the-pancreas
#6
Atakan Tanacan, Gokcen Orgul, Ahmet Bülent Dogrul, Fatih Aktoz, Osman Abbasoglu, M Sinan Beksac
A 26-year-old primigravid patient, at 35 weeks and 2 days of gestation, was referred to Hacettepe University Hospital for pancreatic mass, giant cervical myoma, maternal systemic lupus erythematosus, thrombocytopenia, and onset of preterm labor. At 36 weeks and 1 day of gestation (6 days after admission to the hospital), regular uterine contractions started and cervical dilatation with effacement was observed. Because of breech presentation and giant cervical myoma, a cesarean section was performed on the primigravid patient under general anesthesia...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29842811/pharmacological-treatment-options-for-severe-hypertriglyceridemia-and-familial-chylomicronemia-syndrome
#7
Rabia Chaudry, Adie Viljoen, Anthony S Wierzbicki
A spectrum of disorders, ranging from rare severe cases of homozygous null lipoprotein lipase deficiency (LPLD) -familial chylomicronemia syndrome (FCS) to heterozygous missense LPLD or polygenic causes, result in hypertriglyceridemia and pancreatitis. The effects of mutations are exacerbated by environmental factors such as diet, pregnancy and insulin resistance. Areas covered: In this review, authors discuss chronic treatment of FCS by ultra-low fat diets allied with the use of fibrates, omega-3 fatty acids, niacin, statins and insulin-sensitising therapies depending on the extent of residual LPL activity; novel therapies in development target triglyceride-rich lipoprotein particle clearance...
May 29, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29805204/comparative-occurrence-of-diabetes-in-canine-feline-and-few-wild-animals-and-their-association-with-pancreatic-diseases-and-ketoacidosis-with-therapeutic-approach
#8
REVIEW
Kamal Niaz, Faheem Maqbool, Fazlullah Khan, Fatima Ismail Hassan, Saeideh Momtaz, Mohammad Abdollahi
Diabetes mellitus (DM) is a chronic metabolic disorder in which blood glucose level raises that can result in severe complications. However, the incidence increased mostly by obesity, pregnancy, persistent corpus luteum, and diestrus phase in humans and animals. This review has focused on addressing the possible understanding and pathogenesis of spontaneous DM in canine, feline, and few wild animals. Furthermore, pancreatic associated disorders, diabetic ketoacidosis, hormonal and drug interaction with diabetes, and herbal remedies associated with DM are elucidated...
April 2018: Veterinary World
https://www.readbyqxmd.com/read/29789944/the-association-between-age-at-menarche-and-later-risk-of-gestational-diabetes-is-mediated-by-insulin-resistance
#9
Clive J Petry, Ken K Ong, Ieuan A Hughes, Carlo L Acerini, David B Dunger
AIMS: Associations have been reported between age at menarche and the later risk of gestational diabetes. However, it is not known whether these associations reflect differences in insulin sensitivity and/or pancreatic β-cell function in pregnancy. METHODS: We examined this question in women enrolled in the prospective Cambridge Baby Growth Study who recalled their age at menarche in questionnaires during pregnancy. Polynomial logistic and linear regression models were used to relate menarche timing to the risk of gestational diabetes, both unadjusted and adjusted for the Homeostasis Model Assessments of insulin resistance (HOMA IR) and pancreatic β-cell function (HOMA B) at week 28 of pregnancy...
May 22, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29777263/folate-treatment-of-pregnant-rat-dams-abolishes-metabolic-effects-in-female-offspring-induced-by-a-paternal-pre-conception-unhealthy-diet
#10
Jian Li, Yong-Ping Lu, Oleg Tsuprykov, Ahmed A Hasan, Christoph Reichetzeder, Mei Tian, Xiao Li Zhang, Qin Zhang, Guo-Ying Sun, Jingli Guo, Mohamed M S Gaballa, Xiao-Ning Peng, Ge Lin, Berthold Hocher
AIMS/HYPOTHESIS: Paternal high-fat diet prior to mating programmes impaired glucose tolerance in female offspring. We examined whether the metabolic consequences in offspring could be abolished by folate treatment of either the male rats before mating or the corresponding female rats during pregnancy. METHODS: Male F0 rats were fed either control diet or high-fat, high-sucrose and high-salt diet (HFSSD), with or without folate, before mating. Male rats were mated with control-diet-fed dams...
May 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29751773/an-unusual-finding-in-a-desmoid-type-fibromatosis-of-the-pancreas-a-case-report-and-review-of-the-literature
#11
Joseph Clarence Torres, Chen Xin
BACKGROUND: Desmoid-type fibromatoses are rare benign and fibrous tumors that account for approximately 0.03% of total neoplasms. Within this category of neoplasms, pancreatic desmoid-type fibromatosis is an extremely rare subgroup, accounting for approximately 5% of desmoid-type fibromatoses. Although the etiology is unknown, some risk factors include trauma, surgery, family history of desmoid tumor, pregnancy, use of contraceptives, genetic mutation, and familial adenomatous polyposis or Gardner syndrome...
May 12, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29735580/natural-history-clinical-manifestations-and-pathogenesis-of-hepatitis-e-virus-genotype-1-and-2-infections
#12
Rakesh Aggarwal, Amit Goel
Infection with genotype 1 or 2 hepatitis E virus (HEV) results primarily from human-to-human transmission through the fecal-oral route in low-resource countries. It presents primarily as "acute viral hepatitis" syndrome, usually a self-limiting illness. A few cases progress to acute liver failure, a serious illness with high fatality. Clinical disease is infrequent among children. Infection during pregnancy is associated with a higher risk of symptomatic disease, severe liver injury, and mortality...
May 7, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29686779/valproic-acid-exposure-of-pregnant-rats-during-organogenesis-disturbs-pancreas-development-in-insulin-synthesis-and-secretion-of-the-offspring
#13
Komariah Komariah, Wasmen Manalu, Bambang Kiranadi, Adi Winarto, Ekowati Handharyani, M Orliando Roeslan
Valproic acid (VPA) plays a role in histone modifications that eventually inhibit the activity of histone deacetylase (HDAC), and will affect the expressions of genes Pdx1, Nkx6.1, and Ngn3 during pancreatic organogenesis. This experiment was designed to study the effect of VPA exposure in pregnant rats on the activity of HDAC that controls the expression of genes regulating the development of beta cells in the pancreas to synthesize and secrete insulin. This study used 30 pregnant Sprague-Dawley rats, divided into 4 groups, as follows: (1) a control group of pregnant rats without VPA administration, (2) pregnant rats administered with 250 mg VPA on day 10 of pregnancy, (3) pregnant rats administered with 250 mg VPA on day 13 of pregnancy, and (4) pregnant rats administered with 250 mg VPA on day 16 of pregnancy...
April 2018: Toxicological Research
https://www.readbyqxmd.com/read/29681182/fetal-pancreatic-langerhans-islets-size-in-pregnancies-with-metabolic-disorders
#14
Laura Avagliano, Margaret Mascherpa, Valentina Massa, Patrizia Doi, Gaetano P Bulfamante
OBJECTIVE: Metabolic disorders are a pandemic and increasing health problem. Women of childbearing age may also be affected, thus an abnormal metabolism may interfere with pregnancy short- and long-term outcomes, harming both mother and child. In the context of an abnormal maternal and intrauterine metabolic milieu the development of fetal organs, including pancreas, may be affected. AIM: To investigate the effects of pregnancy metabolic disorders on the morphology of pancreatic Langerhans islets in human late-third trimester stillborn fetuses...
May 6, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29658450/-influence-of-acute-pancreatitis-in-pregnancy-on-pregnancy-outcomes-and-neonates
#15
Shu-Juan Fan, Jun-Xi Xiang, Mi Xiao, Fang-Hui Wang, Xiao-Jie Lin, Xi-Hui Zhou, Ting Ai, Li Liu
OBJECTIVE: To study the influence of acute pancreatitis in pregnancy (APIP) on pregnancy outcomes and neonates. METHODS: A retrospective analysis was performed for 33 APIP patients and 31 neonates born alive. RESULTS: Of the 33 APIP patients, 26 (79%) developed APIP in the late pregnancy. Fourteen (45%) patients had hyperlipidemic APIP, 13 (42%) had biliary APIP, and 4 (13%) had other types of APIP. According to the severity, 22 (67%) were mild APIP, 5 (15%) were moderate APIP, and 6 were severe APIP...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29650351/overexpression-of-st5-an-activator-of-ras-has-no-effect-on-%C3%AE-cell-proliferation-in-adult-mice
#16
Kristy Ou, Jia Zhang, Yang Jiao, Zhao V Wang, Phillipp Scherer, Klaus H Kaestner
OBJECTIVE: Both Type I and Type II diabetes mellitus result from insufficient functional β-cell mass. Efforts to increase β-cell proliferation as a means to restore β-cell mass have been met with limited success. Suppression of Tumorigenicity 5 (ST5) activates Ras/Erk signaling in the presence of Epidermal Growth Factor (EGF). In the pancreatic islet, Ras/Erk signaling is required for augmented β-cell proliferation during pregnancy, suggesting that ST5 is an appealing candidate to enhance adult β-cell proliferation...
May 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29623207/a-rare-case-of-hypercalcemia-induced-pancreatitis-in-a-first-trimester-pregnant-woman
#17
Carine Ghassan Richa, Khadija Jamal Saad, Ali Khaled Chaaban, Mohamad Souheil El Rawas
The objective of the study is to report a case of acute pancreatitis secondary to hypercalcemia induced by primary hyperparathyroidism in a pregnant woman at the end of the first trimester. The case included a 32-year-old woman who was diagnosed with acute pancreatitis and severe hypercalcemia refractory to many regimens of medical therapy in the first trimester of pregnancy. She was successfully treated with parathyroidectomy in the early second trimester with complete resolution of hypercalcemia and pancreatitis...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29607233/preterm-parturient-with-polyhydramnios-and-pancreatitis-primary-presentation-of-hyperparathyroidism
#18
Esther S Han, Katherine Fritton, Phoebe Bacon, Martin K Slodzinski, Cynthia Argani
Objective: To report a case of severe hypercalcemia secondary to primary hyperparathyroidism in a late-preterm pregnant patient and review medical and surgical treatments as well as obstetric and neonatal outcomes. Background: Diagnosis of parathyroid disease during pregnancy can be difficult due to nonspecific presentation. Management decisions are complex and require multidisciplinary collaboration. Case: A 29-year-old G2P1001 woman at 35 weeks and 3 days' gestation presented with preterm contractions, polyhydramnios, pancreatitis, and severe hypercalcemia...
2018: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29594255/enhanced-expression-of-the-key-mitosis-regulator-cyclin-b1-is-mediated-by-pdz-binding-kinase-in-islets-of-pregnant-mice
#19
Tadayoshi Uesato, Takeshi Ogihara, Akemi Hara, Hitoshi Iida, Takeshi Miyatsuka, Yoshio Fujitani, Satoru Takeda, Hirotaka Watada
The proliferation of pancreatic β cells is enhanced to enable an increase in β -cell mass and to compensate for insulin resistance during pregnancy. To elucidate the mechanisms involved, we previously investigated islets from pregnant and nonpregnant mice by gene expression profiling and found that the expression of postsynaptic density-95/Discs large/zonula occludens-1 (PDZ)-binding kinase (Pbk), a member of the mitogen-activated protein kinase kinase family, is increased in pregnant mouse islets compared with control mouse islets...
March 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29557755/the-inhibitory-effect-of-some-drugs-on-candida-rugosa-lipase-and-pancreatic-human-lipase-in-vitro-and-in-silico-studies
#20
Talia Serseg, Khedidja Benarous
Side effects of some drugs may be useful in certain cases. In this work, we studied the inhibitory effects of some medications as: Folic Acid which is taken by pregnant women, Colchicine and Febuxostat which is used as treatment of gout disease. These cases are linked to obesity, where women (BMI ≥ 30) have twice higher odds of having an NTD-affected pregnancy than the normal weight women, and the Gout disease frequently occurs in combination of a Metabolic syndrome. The risk of gout increases with the increase of the mass index...
March 18, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
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