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https://www.readbyqxmd.com/read/28208844/spectrum-of-factors-triggering-endothelial-dysfunction-in-pih
#1
Visala Sree Jammalamadaga, Philips Abraham
INTRODUCTION: Pre-eclampsia (PE) is a major cause of maternal and fetal/neonatal mortality and morbidity. The aetiology and pathogenesis of PE is yet to be completely understood. Evidence shows that, Endothelial Dysfunction (ED) plays a pivotal role in the genesis of this multi-system disorder that develops in PE and eclampsia. AIM: To determine the circulating levels of factors Malondialdehyde (MDA), Ferric Reducing Ability of Plasma-α (FRAP), Tumour Necrosis Factor (TNF-α), sFlt-1, VEGF, PlGF, Nitric Oxide (NO) that influence the ED...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28198634/phase-composition-control-in-microsphere-supported-biomembrane-systems
#2
Eric S Fried, Yue-Ming Li, Malcolm Lane Gilchrist
The popularization of studies in membrane protein lipid phase coexistence has prompted the development of new techniques to construct and study biomimetic systems with cholesterol-rich lipid microdomains. Here, microsphere supported biomembranes with integrated α-helical peptides, referred to as proteolipobeads (PLBs), were used to model peptide/protein partitioning within DOPC/DPPC/cholesterol phase-separated membranes. Due to the appearance of compositional heterogeneity and impurities in the formation of model PLB assemblies, fluorescence-activated cell sorting (FACS) was used to characterize and sort PLB populations on the basis of disordered phase (Ld) content...
February 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28193408/physicochemical-characterization-antioxidant-capacity-total-phenolic-and-proanthocyanidin-content-of-flours-prepared-from-pequi-caryocar-brasilense-camb-fruit-by-products
#3
Daniela P Leão, Adriana S Franca, Leandro S Oliveira, Rita Bastos, Manuel A Coimbra
The potential of pequi by-products as substrates for the production of flours rich in antioxidant dietary fibers was evaluated. Dietary fiber contents ranged from 39.8 to 43.3g/100g with pectic polysaccharide fraction constituted of rhamnogalacturonans and hemicellulose fraction consisted of arabinogalactans, xylans and glucomannans. Total polyphenols, non-extractable proanthocyanidins (NEPA) and carotenoid contents of the flours were determined (respectively, 15.5-17.4g GAE/100g, 215.54-346.84mg/100g and 2116...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28192301/dynamic-interaction-between-actin-and-nesprin2-maintain-the-cell-nucleus-in-a-prestressed-state
#4
Abhishek Kumar, G V Shivashankar
Mechanical coupling between the nucleus and the cytoskeleton is indispensable for direct force transduction from the extra cellular matrix (ECM) to the chromatin. Although this physical coupling has been shown to be crucial for nuclear positioning and its function, the quantification of nuclear-cytoskeleton interaction has been lacking. In this paper, using various quantitative fluorescence spectroscopy techniques, we investigate the nature of this connection. High-resolution 3D imaging shows that nesprin2G forms short linear structures along actin stress fibers (ASFs) in the apical region of the nucleus...
November 11, 2016: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28188445/evaluation-of-some-phenological-and-biochemical-characteristics-of-selected-new-late-flowering-dried-apricot-cultivars
#5
Burhanettin İmrak, Ali Küden, Veyis Yurtkulu, Ebru Kafkas, Sezai Ercişli, Salih Kafkas
In this study, promising candidates of six apricot genotypes were compared with our local and major cultivar (Hacıhaliloğlu) based on their phenological, pomological, and biochemical characteristics. Fruit weight, stone weight, flesh firmness, flesh fruit/stone ratio, TSS (Total soluble solids), glucose, fructose, sucrose, total phenols, total antioxidant activity (FRAP and ABTS assays) and bud break, first bloom, full bloom, and harvesting date of apricot cultivar candidates were compared with cultivar Hacıhaliloğlu 'HH...
February 10, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28182858/effect-of-exercise-induced-dehydration-on-circulatory-markers-of-oxidative-damage-and-antioxidant-capacity
#6
Vincent P Georgescu, Tacito P Souza-Junior, Christian Behrens, Marcelo P Barros, Carlos Alves Bueno, Alan C Utter, Lisa S McAnulty, Steven R McAnulty
Dehydration is a common event associated with exercise. However, few studies have examined the effects of dehydration on plasma redox status in humans. Eighty-two athletes were recruited and had Baseline anthropometrics and blood samples obtained. Athletes then engaged in a dehydration protocol, training until 3% of pre-weight body mass was lost. Athletes returned to the lab and had Post-dehydration blood collected. Athletes then consumed an isotonic drink until pre-exercise body weight was reestablished. Blood was then recollected (1-h post-full rehydration (PFR))...
February 9, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28178632/impact-of-bioaccessibility-and-bioavailability-of-phenolic-compounds-in-biological-systems-upon-the-antioxidant-activity-of-the-ethanolic-extract-of-triplaris-gardneriana-seeds
#7
José Joaquim Lopes Neto, Thiago Silva de Almeida, Jackeline Lima de Medeiros, Leonardo Rogério Vieira, Thaís Borges Moreira, Ana Isabel Vitorino Maia, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Davi Felipe Farias, Ana Fontenele Urano Carvalho
The most studied bioactive potential of phenolic compounds corresponds to antioxidant activity, which in turn, is associated with a reduction in the incidence of various human diseases. However, the total quantity of these bioactive substances in foods and medicinal preparations does not reflect the amount absorbed and metabolized by the body. The present study aimed to investigate the bioaccessibility of Triplaris gardneriana seeds ethanolic extract (EETg) by determination of phenolic composition and antioxidant activities before and after in vitro digestion as well as to estimate its bioavailability by chemical analysis of plasma and urine in animal models after oral administration...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28177054/propolis-from-southwest-of-parana-produced-by-selected-bees-influence-of-seasonality-and-food-supplementation-on-antioxidant-activity-and-phenolic-profile
#8
Matheus A Calegari, Anaclara Prasniewski, Cleidiane DA Silva, Ricardo Y Sado, Fabiana M C Maia, Larissa M S Tonial, Tatiane L C Oldoni
Propolis produced by selected bees Apis mellifera were collected from March to June of 2013 and in March of 2015 and analyzed in order to evaluate the influence of climate, colony of origin, and food supplementation of colonies on the content of total phenolic and flavonoid by chromatographic analysis and antioxidant activity by radical scavenging of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and ferric reducing antioxidant power (FRAP) methods...
February 6, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28174780/shedding-light-on-the-biological-and-chemical-fingerprints-of-three-achillea-species-a-biebersteinii-a-millefolium-and-a-teretifolia
#9
Gokhan Zengin, Abdurrahman Aktumsek, Ramazan Ceylan, Sengul Uysal, Andrei Mocan, Gokalp Ozmen Guler, M Fawzi Mahomoodally, Jasmina Glamočlija, Ana Ćirić, Marina Soković
Representatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the biological and chemical profiles of different extracts (ethyl acetate, methanol and water) obtained from three Achillea species (A. biebersteinii, A. millefolium and A. teretifolia). The antioxidant (free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), metal chelating and phosphomolybdenum), enzyme inhibitory (anti-cholinesterase, anti-tyrosinase, anti-amylase and anti-glucosidase) and antimicrobial (antibacterial and antifungal) effects were assessed to investigate their biological profiles...
February 8, 2017: Food & Function
https://www.readbyqxmd.com/read/28174084/protective-effect-of-polysaccharide-from-maca-lepidium-meyenii-on-hep-g2-cells-and-alcoholic-liver-oxidative-injury-in-mice
#10
Lijun Zhang, Qingsheng Zhao, Liwei Wang, Mingxia Zhao, Bing Zhao
To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column. The average molecular weight of MP-1 was 1067.3kDa and the polysaccharide purity was 91.63%. In order to assess the antioxidant activities of MP-1, four kinds of methods were used, including scavenging hydroxyl radical, DPPH, superoxide anion radical, and FRAP, and the results indicated high antioxidant activities. Furthermore, hepatoprotective activity of MP-1 was studied both in vitro and vivo...
February 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28167478/the-study-of-polyphenolic-compounds-profile-of-some-rosmarinus-officinalis-l-extracts
#11
Neli-Kinga Olah, Gyongyi Osser, Ramona Flavia Câmpean, Flavia Roxana Furtuna, Daniela Benedec, Lorena Filip, Oana Raita, Daniela Hanganu
The purpose of this study was to compare the polyphenol profile of different Rosemary (Rosmarinus officinalis) extracts obtained from dry and fresh herb and the evaluation of their antioxidant effect. There were studied the polyphenols from hydroalcoholic extracts (1:5- dry plant:solvent) obtained from fresh respectively dry plant and the gemmotherapic extract obtained from fresh plant (1:20- dry plant: solvent). The polyphenol profile was evaluated by UV-Vis spectrophotometry, TLC and HPLC. The total polyphenol respectively flavonoids content were determined by UV-V is spectrophotometry...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28166708/potential-anti-inflammatory-antioxidant-and-antimicrobial-activities-of-sambucus-australis
#12
Jhéssica Benevides Bahiense, Franciane Martins Marques, Mariana Moreira Figueira, Thais Souza Vargas, Tamara P Kondratyuk, Denise Coutinho Endringer, Rodrigo Scherer, Marcio Fronza
CONTEXT: Sambucus australis Cham. & Schltdl. (Adoxaceae) is used in Brazilian folk medicine to treat inflammatory disorders. OBJECTIVE: To evaluate the in vitro anti-inflammatory, antioxidant and antimicrobial properties of S. australis. MATERIALS AND METHODS: The anti-inflammatory activity of ethanol extracts of the leaf and bark of S. australis (1-100 μg/mL) were studied in lipopolysaccharide/interferon γ stimulated murine macrophages RAW 264...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28166649/evaluation-of-plasma-antioxidant-activity-in-rats-given-excess-egcg-with-reference-to-endogenous-antioxidants-concentrations-and-assay-methods
#13
Kaori Yokotani, Keizo Umegaki
The contribution of (-)-epigallocatechin gallate (EGCg) intake to in vivo antioxidant activity is unclear, even with respect to plasma. In this study, we examined how administration of EGCg contributes to plasma antioxidant activity, relative to its concentration, endogenous antioxidants, and assay methods, namely oxygen radical absorbance capacity (ORAC) and ferric reducing/antioxidant power (FRAP). Administration of EGCg (500 mg/kg) to rats increased plasma EGCg (4 µmol/L as free form) and ascorbic acid (1...
February 6, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28166228/rapid-turnover-of-dnaa-at-replication-origin-regions-contributes-to-initiation-control-of-dna-replication
#14
Katrin Schenk, Ana B Hervás, Thomas C Rösch, Marc Eisemann, Bernhard A Schmitt, Stephan Dahlke, Luise Kleine-Borgmann, Seán M Murray, Peter L Graumann
DnaA is a conserved key regulator of replication initiation in bacteria, and is homologous to ORC proteins in archaea and in eukaryotic cells. The ATPase binds to several high affinity binding sites at the origin region and upon an unknown molecular trigger, spreads to several adjacent sites, inducing the formation of a helical super structure leading to initiation of replication. Using FRAP analysis of a functional YFP-DnaA allele in Bacillus subtilis, we show that DnaA is bound to oriC with a half-time of 2...
February 6, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28165019/fungal-endophyte-derived-fritillaria-unibracteata-var-wabuensis-diversity-antioxidant-capacities-in-vitro-and-relations-to-phenolic-flavonoid-or-saponin-compounds
#15
Feng Pan, Tian-Jiao Su, Shi-Mei Cai, Wei Wu
Diverse fungal endophytes are rich fungal resources for the production of an enormous quantity of natural products. In the present study, 53 fungal endophytes were isolated from the bulbs of Fritillaria unibracteata var. wabuensis (FUW). Of these, 49 strains were identified and grouped into 17 different taxa, and priority was conferred to the Fusarium genus. All fungal fermented filtrates displayed antioxidant activities. The DPPH activity, total antioxidant capacities (ABTS), reduction power (FRAP), total phenolic content (TPC), total flavonoid content (TFC) and total saponin content (TSC) were evaluated using petroleum ether, ethyl acetate, n-butyl alcohol and ethanol fractions extracted from five representative fungal cultures...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163113/the-estimation-of-the-traditionally-used-yarrow-achillea-millefolium-l-asteraceae-oil-extracts-with-anti-inflamatory-potential-in-topical-application
#16
Vanja Tadić, Ivana Arsić, Jelena Zvezdanović, Ana Zugić, Dragan Cvetković, Sava Pavkov
ETHNOPHARMACOLOGICAL RELEVANCE: Olive or sunflower oil yarrow extracts have been extensively used against inflammatory disorders and skin wound healing in traditional medicine. AIM OF THE STUDY: To evaluate oil yarrow extracts traditional use in treatment of topical/dermatological skin impairments, sodium lauryl sulfate test was applied, and in vivo measuring of the biophysical parameters (erythema index, skin capacitance and the pH of the skin) in the artificially irritated skin was performed...
February 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28161540/genome-organization-in-the-nucleus-from-dynamic-measurements-to-a-functional-model
#17
REVIEW
Anat Vivante, Eugene Brozgol, Irena Bronshtein, Yuval Garini
A biological system is by definition a dynamic environment encompassing kinetic processes that occur at different length scales and time ranges. To explore this type of system, spatial information needs to be acquired at different time scales. This means overcoming significant hurdles, including the need for stable and precise labeling of the required probes and the use of state of the art optical methods. However, to interpret the acquired data, biophysical models that can account for these biological mechanisms need to be developed...
February 1, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28159891/an-amidase-is-required-for-proper-intercellular-communication-in-the-filamentous-cyanobacterium-anabaena-sp-pcc-7120
#18
Zhenggao Zheng, Amin Omairi-Nasser, Xiying Li, Chunxia Dong, Yan Lin, Robert Haselkorn, Jindong Zhao
Channels that cross cell walls and connect the cytoplasm of neighboring cells in multicellular cyanobacteria are pivotal for intercellular communication. We find that the product of the gene all1140 of the filamentous cyanobacterium Anabaena sp. PCC 7120 is required for proper channel formation. All1140 encodes an amidase that hydrolyses purified peptidoglycans. An All1140-GFP fusion protein is located at the Z-ring in the periplasmic space during most of the cell cycle. An all1140-null mutant (M40) was unable to grow diazotrophically, and no mature heterocysts were observed in the absence of combined nitrogen...
February 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28152668/evaluation-of-the-antioxidant-activity-of-betula-pendula-leaves-extract-and-its-effects-on-model-foods
#19
Nurul Aini Mohd Azman, Monika Skowyra, Kwestan Muhammad, María Gabriela Gallego, Maria Pilar Almajano
CONTEXT: Betula pendula Roth (Betulaceae) exhibits many pharmacological activities in humans including anticancer, antibacterial, and antiviral effects. However, the antioxidant activity of BP towards lipid degradation has not been fully determined. OBJECTIVE: The BP ethanol and methanol extracts were evaluated to determine antioxidant activity by an in vitro method and lyophilized extract of BP was added to beef patties to study oxidative stability. MATERIALS AND METHODS: Antioxidant activities of extracts of BP were determined by measuring scavenging radical activity against methoxy radical generated by Fenton reaction 2,2'-azino-bis-3-ethylbenzothiazoline-6-sulphonic acid (TEAC) radical cation, the oxygen radical absorbance capacity (ORAC) and the ferric reducing antioxidant power (FRAP) assays...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28152649/anti-inflammatory-anti-cholinergic-and-cytotoxic-effects-of-sida-rhombifolia
#20
Siau Hui Mah, Soek Sin Teh, Gwendoline Cheng Lian Ee
CONTEXT: Sida (Malvaceae) has been used as a traditional remedy for the treatment of diarrhoea, malarial, gastrointestinal dysentery, fevers, asthma and inflammation. OBJECTIVES: This study evaluates the anti-inflammatory, cytotoxic and anti-cholinergic activities of Sida rhombifolia Linn. whole plant for the first time. MATERIALS AND METHODS: S. rhombifolia whole plant was extracted by n-hexane, ethyl acetate and methanol using Soxhlet apparatus...
December 2017: Pharmaceutical Biology
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