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https://www.readbyqxmd.com/read/28812474/protective-effect-of-raisin-currant-against-spatial-memory-impairment-and-oxidative-stress-in-alzheimer-disease-model
#1
Mohammad Gol, Davoud Ghorbanian, Nabiollah Soltanpour, Jamshid Faraji, Mohsen Pourghasem
OBJECTIVES: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive pathological changes of the brain. A number of studies demonstrated compelling evidence of the importance of oxidative processes in AD pathogenesis. Raisin contains polyphenol, phenolic acid, and tannin compounds, which have antioxidant and anti-inflammatory properties. The present study was aimed to evaluate the protective effect of raisin on neurobehavioral and histological changes in rats with Alzheimer...
August 16, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28808393/evaluation-of-the-antidiabetic-properties-of-s-1708-mulberry-variety
#2
Brijesh Ranjan, Randhir Kumar, Neeraj Verma, Swati Mittal, Pranab Lal Pakrasi, R Venkatesh Kumar
BACKGROUND: Diabetes is a metabolic disease prevalent worldwide in all age group of people. The source of diabetes is due to an oxidation process that can produce free radicals. An increase in oxidative free radicals in the body is reported to be one of the several causes of diabetes. The best remedy to combat oxidative stress is the use of antioxidants, which inhibit and scavenge free radicals. AIM: This study has been undertaken to evaluate the antioxidant activity and antidiabetic effect of mulberry leaf extract in diabetic mice...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28797651/biological-effects-and-chemical-characterization-of-iris-schachtii-markgr-extracts-a-new-source-of-bioactive-constituents
#3
Andrei Mocan, Gokhan Zengin, Adriano Mollica, Ahmet Uysal, Erdogan Gunes, Gianina Crișan, Abdurrahman Aktumsek
This study gathers information about the effects of different extracts (methanol and water) from rhizomes and aerial parts of Iris schachtii on selected enzymes (cholinesterases, alpha-amylase and alpha-glucosidase, tyrosinase and lipase) as well as on their antioxidant capacities and antimutagenic properties in relation with their phenolic composition. The chemical composition was assessed by determining total phenolic and flavonoid content as well as individual phenolic compounds by HPLC-DAD. Moreover, antioxidant abilities of the investigated extracts were tested by using different assays including free radical scavenging (DPPH and ABTS), reducing power (CUPRAC and FRAP), phosphomolybdenum and metal chelating, overall rhizomes being indicated as a superior source of antioxidant compounds...
August 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28791812/relationship-between-dietary-antioxidant-index-dai-and-antioxidants-level-in-plasma-of-krak%C3%A3-w-inhabitants
#4
Emilia Kolarzyk, Agata Pietrzycka, Joanna Zając, Joanna Morawiecka-Baranek
BACKGROUND: Some literature data indicate that antioxidant-rich food may significantly increase antioxidants in serum and decrease the oxidative stress but results are ambiguous. OBJECTIVES: The aim of this study was to estimate the total antioxidant capacity of food intake among the inhabitants of Kraków, Poland on the basis of dietary antioxidant index (DAI) and evaluation the relation between DAI and the level of antioxidants in plasma. MATERIAL AND METHODS: Examination included 70 (37 women and 33 men) non-smoking inhabitants of Krakow aged 46...
May 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28790172/postsynaptic-density-95-psd-95-serine-561-phosphorylation-regulates-a-conformational-switch-and-bidirectional-dendritic-spine-structural-plasticity
#5
Qian Wu, Miao Sun, Laura P Bernard, Huaye Zhang
PSD-95 is a major synaptic scaffolding protein that plays a key role in bidirectional synaptic plasticity, which is a process important for learning and memory. It is known that PSD-95 shows increased dynamics upon induction of plasticity. Yet the underlying structural and functional changes in PSD-95 that mediate its role in plasticity remain unclear. Here we show that phosphorylation of PSD-95 at Ser561 in its GK domain, which is mediated by the partitioning defective 1 (Par1) kinases, regulates a conformational switch and is important for bidirectional plasticity...
August 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28777516/hyperbaric-oxygenation-affects-the-mechanisms-of-acetylcholine-induced-relaxation-in-diabetic-rats
#6
Sanela Unfirer, Martina Mihalj, Sanja Novak, Aleksandar Kibel, Ava Cavka, Zrinka Mijalevic, Mario Gros, Ivica Brizic, Danijela Budimir, Anita Cosic, Mladen Boban, Ines Drenjancevic
The effects of hyperbaric oxygenation (HBO₂) on acetylcholine-induced vasorelaxation (AChIR) were evaluated in male Sprague-Dawley (SD) rats randomized into four groups: healthy controls (Ctrl), diabetic rats (DM), and control and diabetic rats that underwent hyperbaric oxygenation (Ctrl+HBO₂ and DM+HBO₂). AChIR was measured in aortic rings, with L-NAME, indomethacin, or MS-PPOH and a combination of inhibitors. mRNA expression of eNOS, iNOS, COX-1 and COX-2 was assessed by qPCR, and protein expression of CYP4A(1-3) by Western blot...
November 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28774179/antioxidant-potential-assessment-of-phenolic-and-flavonoid-rich-fractions-of-clematis-orientalis-and-clematis-ispahanica-ranunculaceae
#7
Ehsan Karimi, Majid Ghorbani Nohooji, Meisam Habibi, Mahdi Ebrahimi, Ali Mehrafarin, Farahnaz Khalighi-Sigaroodi
The antioxidant activities of crude extract fractions using Hexane, Chloroform, Ethyl Acetate, Butanol and Water of Clematis orientalis and Clematis ispahanica were investigated. 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and the ferric reducing/antioxidant potential (FRAP) were used to evaluate the antioxidant capacity. The total phenolics were found to be 4.37-9.38 and 1.32-11.37 mg gallic acid equivalents (GAE)/g in different fractions for C. orientalis and C. ispahanica, respectively. The ethyl acetate fraction of C...
August 3, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28771735/polyphenol-content-in-vitro-bioaccesibility-and-antioxidant-capacity-of-widely-consumed-beverages
#8
Gema Baeza, Beatriz Sarriá, Laura Bravo, Raquel Mateos
BACKGROUND: Beverages prepared from antioxidant rich plants are sources of polyphenols, which bioactivity depends on bioaccesibility in the gastrointestinal tract. This work evaluated the polyphenol content and antioxidant capacity of widely consumed beverages such as chamomile tea, yerba mate, a coffee blend (65% roasted:35% green), and coffee-like substitutes such as chicory, malt and a soluble cereal mixture. Additionally, the bioaccesibility of the two beverages with the highest antioxidant capacity was evaluated using an in vitro digestion model...
August 3, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28764014/generation-of-bioactive-peptides-from-duck-meat-during-post-mortem-aging
#9
Dongmei Liu, Xing Chen, Jichao Huang, Ming Huang, Guanghong Zhou
The objective of this study was to investigate the endogenous release of bioactive peptides in duck meat during 7days of post-mortem aging. The degradation of muscle proteins led to release of small peptides (<5kDa). The peptides formed in the samples after 3days post-mortem exhibited highest DPPH radical scavenging, oxygen radical scavenging (ORAC) and ferric reducing antioxidant power (FRAP). By using size-exclusion chromatography, the initial extract was purified into three fractions (A-C) in which fraction C exhibited the highest antioxidant activity...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28763958/electroanalysis-and-laccase-based-biosensor-on-the-determination-of-phenolic-content-and-antioxidant-power-of-honey-samples
#10
Jerônimo Raimundo de Oliveira Neto, Stefani Garcia Rezende, Gérman Sanz Lobón, Telma Alves Garcia, Isaac Yves Lopes Macedo, Luane Ferreira Garcia, Virgínia Farias Alves, Ieda Maria Sapateiro Torres, Mariângela Fontes Santiago, Fernando Schmidt, Eric de Souza Gil
Honey is a functional food widely consumed. Thus, the evaluation of honey samples to determine its phenolic content and antioxidant capacity (AOC) is relevant to determine its quality. Usually AOC is performed by spectrophotometric methods, which lacks reproducibility and practicality. In this context, the electroanalytical methods offer higher simplicity and accuracy. Hence, the aim of this work was to use of electroanalytical tools and laccase based biosensor on the evaluation of AOC and total phenol content (TPC) of honey samples from different countries...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28761622/flavonoids-as-putative-inducers-of-the-transcription-factors-nrf2-foxo-and-ppar%C3%AE
#11
Kathrin Pallauf, Nils Duckstein, Mario Hasler, Lars-Oliver Klotz, Gerald Rimbach
Dietary flavonoids have been shown to extend the lifespan of some model organisms and may delay the onset of chronic ageing-related diseases. Mechanistically, the effects could be explained by the compounds scavenging free radicals or modulating signalling pathways. Transcription factors Nrf2, FoxO, and PPARγ possibly affect ageing by regulating stress response, adipogenesis, and insulin sensitivity. Using Hek-293 cells transfected with luciferase reporter constructs, we tested the potency of flavonoids from different subclasses (flavonols, flavones, flavanols, and isoflavones) to activate these transcription factors...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28761496/antioxidant-properties-of-crude-extract-partition-extract-and-fermented-medium-of-dendrobium-sabin-flower
#12
Farahziela Abu, Che Norma Mat Taib, Mohamad Aris Mohd Moklas, Sobri Mohd Akhir
Antioxidant properties of crude extract, partition extract, and fermented medium from Dendrobium sabin (DS) flower were investigated. The oven-dried DS flower was extracted using 100% methanol (w/v), 100% ethanol (w/v), and 100% water (w/v). The 100% methanolic crude extract showed the highest total phenolic content (40.33 ± mg GAE/g extract) and the best antioxidant properties as shown by DPPH, ABTS, and FRAP assays. A correlation relationship between antioxidant activity and total phenolic content showed that phenolic compounds were the dominant antioxidant components in this flower extract...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28758958/evaluation-of-antioxidant-activity-and-growth-control-properties-of-nonoscale-structure-produced-from-aloe-vera-var-littoralis-extract-on-clinical-isolates-of-salmonella
#13
Reza Ranjbar, Mohammad Arjomandzadegan, Hossein Hosseiny
The aim of the study was to examine antibacterial properties of microemulsion structure produced from Aloe vera var. littoralis extract as a new tool of nanoscale drug-like materials. Aloe vera var. littoralis (A. littoralis) extract was prepared by distillation method. A nonocarrier structure in the microemulsion system was prepared from the extract. Serial concentrations were prepared from 8 mg/mL extract and the nonocarrier containing 0.1 mg/mL pure extract and were evaluated by a disk diffusion method for 35 Salmonella clinical isolates...
July 31, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28758603/vitamin-d-deficiency-oxidative-stress-and-antioxidant-status-only-weak-association-seen-in-the-absence-of-advanced-age-obesity-or-pre-existing-disease
#14
Erica W Wang, Parco M Siu, Marco Y Pang, Jean Woo, Andrew R Collins, Iris F F Benzie
Vitamin D deficiency (plasma 25-hydroxycholecalciferol (25(OH)D)70 % of participants were vitamin D deficient. No significant correlations and no biomarker differences across 25(OH)D quartiles or groups were seen except for total antioxidant status. A weak direct association (r 0·252, P<0·05) was observed between 25(OH)D and FRAP, and those in the lowest 25(OH)D quartile and group had significantly lower FRAP values. Results did not reveal a clear link between vitamin D status and oxidative stress biomarkers in the absence of advanced age, obesity and disease, though some evidence of depleted antioxidant status in those with vitamin D deficiency was seen...
July 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28753316/inhibitory-potential-of-red-cabbage-against-digestive-enzymes-linked-to-obesity-and-type-2-diabetes
#15
Anna Podsędek, Iwona Majewska, Alicja Z Kucharska
Assays of the inhibitory potential against enzymes involved in carbohydrate and lipid digestion (α-amylase, α-glucosidase, and lipase) as well as the total contents of phenolics and anthocyanins, anthocyanin profile, and antioxidant capacity revealed significant differences (p < 0.05) between five varieties of red cabbage. Among the varieties, the highest inhibitory activity against α-glucosidase (IC50 = 3.87 ± 0.12 mg dry weight (DW) of cabbage/mL) and lipase (IC50 = 1.57 ± 0.06 mg DW/mL) was exhibited by the Koda variety, which showed the highest antioxidant capacity in ABTS (Trolox equivalent antioxidant capacity (TEAC) = 141 ± 4...
August 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28750167/comparison-of-antioxidant-evaluation-assays-for-investigating-antioxidative-activity-of-gallic-acid-and-its-alkyl-esters-in-different-food-matrices
#16
Natthaporn Phonsatta, Pawinee Deetae, Pairoj Luangpituksa, Claudia Grajeda-Iglesias, Maria Cruz Figueroa-Espinoza, Jérôme Le Comte, Pierre Villeneuve, Eric A Decker, Wonnop Visessanguan, Atikorn Panya
The addition of antioxidants is one of the strategies to inhibit lipid oxidation, a major cause of lipid deterioration in foods leading to rancidity development and nutritional losses. However, several studies have been reported that conventional antioxidant assays, e.g., TPC, ABTS, FRAP, and ORAC could not predict antioxidant performance in several foods. This study aimed to investigate the performance of two recently developed assays, e.g., the conjugated autoxidizable triene (CAT) and the apolar radical-initiated conjugated autoxidizable triene (ApoCAT) assays to predict the antioxidant effectiveness of gallic acid and its esters in selected food models in comparison with the conventional antioxidant assays...
August 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28748169/evaluation-of-fibrinolytic-and-antioxidant-effects-of-allium-elburzense-bulb-extracts
#17
Leila Safaeian, Behzad Zolfaghari, Mohammadreza Aghaye-Ghazvini, Mahya Behnampour
OBJECTIVE: Allium elburzense is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of A. elburzense bulb extracts. MATERIALS AND METHODS: Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. In vitro antioxidant assays were performed using total phenolic, DPPH, and FRAP methods...
May 2017: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/28740293/ultrasound-assisted-extraction-process-of-phenolic-antioxidants-from-olive-leaves-a-nutraceutical-study-using-rsm-and-lc-esi-dad-ms
#18
Habib Shirzad, Vahid Niknam, Mehdi Taheri, Hassan Ebrahimzadeh
In recent years, there has been an ever growing interest in finding new natural sources of food antioxidants. As a main fruit crop, olive is also valued due to its phenolic-containing leaves. Mathematically based optimization methods are used as powerful tools to extract different antioxidant compounds. The present study is aimed to provide an efficient extraction method for total phenol content (TPC), total flavonoid content (TFC) and antioxidant ability (DPPH scavenging assay and FRAP). The effects of ultrasonic temperature (35-65 °C), ultrasonic time (5-15 min), and ethanol to water ratio (Et: W) (25-75%) were evaluated...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28740289/antioxidant-efficiency-of-polyphenols-from-coffee-and-coffee-substitutes-electrochemical-versus-spectrophotometric-approach
#19
Stanislava Gorjanović, Draženka Komes, Jovanka Laličić-Petronijević, Ferenc T Pastor, Ana Belščak-Cvitanović, Mile Veljović, Lato Pezo, Desanka Ž Sužnjević
Antioxidant (AO) capacity of instant, espresso, filter and Turkish/Greek coffee brews, coffee substitutes (roasted chicory root, barley, pea, chickpea, carob and dried fig) and individual compounds (phenolic acids, flavonoids, methylxanthines, N-methyl pyridinium and HMW melanoidins) was assessed using DC polarographic assay based on decrease of anodic current originating from hydroxo-perhydroxo mercury complex formed in alkaline solutions of H2O2 at potential of mercury dissolution, as well as three spectrophotometric assays (DPPH, ABTS and FRAP)...
July 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28738692/flavonoid-profile-antioxidant-and-antiglycation-properties-of-retama-sphaerocarpa-fruits-extracts
#20
S Boussahel, F Cacciola, S Dahamna, L Mondello, A Saija, F Cimino, A Speciale, M Cristani
Retama sphaerocarpa occurs in the Mediterranean area of North-east Africa and in the Iberian Peninsula, and grows on a variety of soil types and climatic conditions. Used in Algerian folk medicine, it is a valuable species for revegetation and soil restoration. The aim of this study is to evaluate flavonoid composition and antioxidant and antiglycation properties of methanolic and aqueous extracts from R. sphaerocarpa fruits. HPLC-PDA/ESI-MS was used to identify/quantify flavonoid content. Antioxidant activity was evaluated by Folin-Ciocalteu, ORAC, FRAP, TEAC, and DPPH assays, and antiglycation capability by glucose/fructose-BSA assay...
July 24, 2017: Natural Product Research
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