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Flaviviridae

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https://www.readbyqxmd.com/read/29322688/phylodynamics-of-classical-swine-fever-virus-with-emphasis-on-ecuadorian-strains
#1
A D Garrido Haro, M Barrera Valle, A Acosta, F J Flores
Classic swine fever virus (CSFV) is a Pestivirus from the Flaviviridae family that affects pigs worldwide and is endemic in several Latin American countries. However, there are still some countries in the region, including Ecuador, for which CSFV molecular information is lacking. To better understand the epidemiology of CSFV in the Americas, sequences from CSFVs from Ecuador were generated and a phylodynamic analysis of the virus was performed. Sequences for the full-length glycoprotein E2 gene of twenty field isolates were obtained and, along with sequences from strains previously described in the Americas and from the most representative strains worldwide, were used to analyse the phylodynamics of the virus...
January 10, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29322674/exposure-to-west-nile-virus-and-tick-borne-encephalitis-virus-in-dogs-in-spain
#2
I García-Bocanegra, E Jurado-Tarifa, D Cano-Terriza, R Martínez, J E Pérez-Marín, S Lecollinet
In the past decade, the spread of emerging zoonotic flaviviruses (genus Flavivirus, family Flaviviridae) has been reported in many regions worldwide, representing a threat to both human and animal health. A serosurvey was carried out to assess exposure and risk factors associated with antigenically related flaviviruses, particularly West Nile virus (WNV), Usutu virus (USUV) and tick-borne encephalitis virus (TBEV), in dogs in Spain. Flavivirus antibodies were detected in 39 of 815 dogs (4.8%; 95% CI: 3.3-6...
January 11, 2018: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29319591/zika-virus-infection-in-the-pregnant-woman
#3
Meghan Holtzman, William C Golden, Jeanne S Sheffield
Zika virus is a single-stranded RNA virus from the Flaviviridae family. Transmission is typically from the bite of an infected mosquito though mother-to-child, sexual and blood donation transmissions can occur. Although maternal symptoms are uncommon and rarely severe, the consequences of congenital infections are devastating. The emergence of congenital Zika syndrome is a world-wide public health crisis. The Centers for Disease Control and Prevention, ACOG, and SMFM have developed algorithms for screening and managing women exposure to and diagnosed with Zika virus infection...
January 9, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29306002/bovine-viral-diarrhea-virus-genomic-variation-within-persistently-infected-cattle
#4
A Chernick, A Ambagala, K Orsel, J D Wasmuth, G van Marle, F van der Meer
Bovine viral diarrhea virus (BVDV) is a single stranded RNA virus in the family Flaviviridae that causes a form of persistent infection. If a fetus is infected in utero during the first 120days of gestation the resulting calf will be immunotolerant to the infecting strain and maintain the virus for life. These animals are epidemiologically important in maintaining BVDV on farms, but also present a unique opportunity to study quasispecies in vivo in the absence of significant selection by the host adaptive immune response...
January 3, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29297305/pharmacophore-anchor-models-of-flaviviral-ns3-proteases-lead-to-drug-repurposing-for-denv-infection
#5
Nikhil Pathak, Mei-Ling Lai, Wen-Yu Chen, Betty-Wu Hsieh, Guann-Yi Yu, Jinn-Moon Yang
BACKGROUND: Viruses of the flaviviridae family are responsible for some of the major infectious viral diseases around the world and there is an urgent need for drug development for these diseases. Most of the virtual screening methods in flaviviral drug discovery suffer from a low hit rate, strain-specific efficacy differences, and susceptibility to resistance. It is because they often fail to capture the key pharmacological features of the target active site critical for protein function inhibition...
December 28, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29291210/the-role-of-the-placenta-in-prenatally-acquired-zika-virus-infection
#6
EDITORIAL
Mohammad Zare Mehrjardi, Farzaneh Shobeirian
Zika virus (ZIKV) is an arthropod-borne arbovirus from the family Flaviviridae, which has been recently confirmed to cause severe neurological abnormalities (such as microcephaly, brain parenchymal calcification, hydrocephalus, and malformations of cortical development) in the infected fetuses. The Placenta plays a multifold role in prenatally acquired ZIKV infection. It serves as a port of virus transmission to the fetus, and also can be directly affected by ZIKV leading to a diminished fetal blood supply or a disrupted/changed biological mediators' synthesis...
September 2017: Virusdisease
https://www.readbyqxmd.com/read/29283327/genetically-modified-aedes-aegypti-to-control-dengue-a-review
#7
Muhammad Qsim, Usman Ali Ashfaq, Muhammad Zubair Yousaf, Muhammad Shareef Masoud, Ijaz Rasul, Namrah Noor, Azfar Hussain
Dengue is an acute infectious disease of viral etiology characterized by lymphadenopathy, leucopenia, headache, biphasic fever, pain in various parts of the body, rashes, and extreme physical weakness. It is a vector-borne disease caused by a positive-stranded RNA virus of the family Flaviviridae, genus Flavivirus. Dengue inflicts a significant health, economic, and social burden on populations of endemic areas. Dengue virus is transmitted to humans by the mosquito vector Aedes aegypti. Vaccines against dengue viruses have been claimed to be developed, but as yet no effective treatment is available...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29258771/identification-of-novel-small-molecule-inhibitors-of-zika-virus-infection
#8
Ewa D Micewicz, Ronik Khachatoorian, Samuel W French, Piotr Ruchala
The recent re-emergence of Zika virus (ZIKV), a member of the Flaviviridae family, has become a global emergency and a serious public health threat worldwide. ZIKV infection causes severe neuroimmunopathology and is particularly harmful to the developing fetuses of infected pregnant women causing various developmental abnormalities. Currently, there are no effective methods of preventing or treating ZIKV infection, and new treatment options are urgently needed. Therefore, we have used an in vitro plaque assay to screen a limited proprietary library of small organic compounds and identified highly bioactive leads, with the most active analogs showing activity in low picomolar range...
December 9, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29247709/single-nucleotide-polymorphism-rs1800872-in-the-promoter-region-of-the-il10-gene-is-associated-with-predisposition-to-chronic-hepatitis-c-in-russian-population
#9
Andrey V Barkhash, Galina V Kochneva, Elena V Chub, Aida G Romaschenko
Previously, we studied an association of two IL28B gene single nucleotide polymorphisms (SNPs) and three IL10 gene SNPs with predisposition to tick-borne encephalitis in a Russian population. In this study, a possible involvement of these SNPs in the development of predisposition to chronic hepatitis C (caused by structurally similar, related virus from the Flaviviridae family) was investigated in the same population. Only the IL10 promoter rs1800872 SNP was associated with predisposition to chronic hepatitis C...
December 13, 2017: Microbes and Infection
https://www.readbyqxmd.com/read/29244615/risk-assessment-for-japanese-encephalitis-vaccination
#10
Lance Turtle, Carolyn Driver
Japanese encephalitis (JE) is the most commonly diagnosed viral encephalitis in Asia. JE is caused by a virus called JE virus (JEV), a member of the genus Flavivirus, family Flaviviridae, and is transmitted by Culex mosquitoes. Neutralising antibody to JEV protects against JE, and can be induced by vaccination. JE is a potential threat to travellers to endemic areas, which are most of South and Southeast Asia and some Pacific Islands. The risk of JE can be expected to increase with increasing mosquito exposure and time spent in regions and seasons of active transmission...
December 15, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29243225/review-current-priorities-in-the-zika-response
#11
REVIEW
Danillo Lucas Alves Esposito, Jonathan Ballico de Moraes, Benedito Antonio Lopes da Fonseca
Zika virus (ZIKV), a single-stranded RNA virus of the Flaviviridae family, is an arbovirus (viruses transmitted by arthropods) transmitted to humans and non-human primates through the bites of infected female Aedes sp. mosquitoes. Although first isolated in 1947, only recently it emerged as a global threat, present in several countries resulting in a pandemic scenario. ZIKV infections may result in severe outcomes, such as neurological impairment, and with the intrinsic ability of inducing microcephaly in fetuses of infected pregnant women, the virus has become a major public health problem...
December 15, 2017: Immunology
https://www.readbyqxmd.com/read/29234310/modulation-of-lipid-droplet-metabolism-a-potential-target-for-therapeutic-intervention-in-flaviviridae-infections
#12
REVIEW
Jingshu Zhang, Yun Lan, Sumana Sanyal
Lipid droplets (LDs) are endoplasmic reticulum (ER)-related dynamic organelles that store and regulate fatty acids and neutral lipids. They play a central role in cellular energy storage, lipid metabolism and cellular homeostasis. It has become evident that viruses have co-evolved in order to exploit host lipid metabolic pathways. This is especially characteristic of the Flaviviridae family, including hepatitis C virus (HCV) and several flaviviruses. Devoid of an appropriate lipid biosynthetic machinery of their own, these single-strand positive-sense RNA viruses can induce dramatic changes in host metabolic pathways to establish a favorable environment for viral multiplication and acquire essential components to facilitate their assembly and traffic...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29216266/identification-and-genetic-characterization-of-hepacivirus-and-pegivirus-in-commercial-equine-serum-products-in-china
#13
Gang Lu, Ji Huang, Qiliang Yang, Haibin Xu, Peixin Wu, Cheng Fu, Shoujun Li
Equine hepacivirus (EqHV), equine pegivirus (EPgV) and Theiler's disease-associated virus (TDAV) are three novel equine viruses in the family Flaviviridae. EqHV and EPgV have been identified to circulate in the equine population worldwide, whereas TDAV has not been detected in equines since the first reported case. To date, no studies have focused on investigating EqHV, EPgV and TDAV in commercial equine sera or equine blood products in China. Considering the potential threat of EqHV, EPgV and TDAV to biosecurity and considering their possible influences on research results, equine sera for cell culture propagation and pregnant mare serum gonadotropin (PMSG) were purchased from different companies in China and investigated for EqHV, EPgV and TDAV in this study...
2017: PloS One
https://www.readbyqxmd.com/read/29210509/arboviruses-and-their-related-infections-in-china-a-comprehensive-field-and-laboratory-investigation-over-the-last-3-decades
#14
REVIEW
Guodong Liang, Xiaolong Li, Xiaoyan Gao, Shihong Fu, Huanyu Wang, Minghua Li, Zhi Lu, Wuyang Zhu, Xinjun Lu, Lihua Wang, Yuxi Cao, Ying He, Wenwen Lei
Since the 1980s, a comprehensive field and laboratory investigation has been conducted throughout China, and a total of 29 virus species belonging to 7 families and 13 genera were identified through virological, morphological, and immunological methods, as well as whole-genome sequencing and molecular genetic analyses. Most of the virus isolates belong to 9 genera in the families Flaviviridae, Bunyaviridae, Togaviridae, and Reoviridae. Among them, 4 genera (Orthobunyavirus, Bunyavirus, Phlebovirus, and Nairovirus) belong to the family Bunyaviridae and 3 genera (Seadonavirus, Orbivirus, and Cypovirus) belong to the family Reoviridae...
December 6, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29202756/pestivirus-infection-in-cattle-dairy-farms-e2-glycoprotein-elisa-reveals-the-presence-of-bovine-viral-diarrhea-virus-type-2-in-northwestern-italy
#15
Chiara Nogarol, Nicola Decaro, Luigi Bertolotti, Barbara Colitti, Bryan Iotti, Stefano Petrini, Maria Stella Lucente, Gabriella Elia, Giovanni Perona, Margherita Profiti, Canio Buonavoglia, Sergio Rosati
BACKGROUND: Bovine viral diarrhea virus (BVDV) types 1 and 2 are members of the Pestivirus genus of the Flaviviridae family. This genus also includes the HoBi-like virus, tentatively classified as BVDV type 3. BVDV-1 is widely distributed in Italy despite the extensive use of BVDV-1-based vaccines, while BVDV-2 and HoBi-like Pestivirus have been detected occasionally. Monitoring the occurrence of sporadic or atypical pestiviruses is a useful approach to evaluate the need for additional vaccine strains that can be used in BVDV control programs...
December 4, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29202041/global-transcriptome-analysis-of-aedes-aegypti-mosquitoes-in-response-to-zika-virus-infection
#16
Kayvan Etebari, Shivanand Hegde, Miguel A Saldaña, Steven G Widen, Thomas G Wood, Sassan Asgari, Grant L Hughes
Zika virus (ZIKV) of the Flaviviridae family is a recently emerged mosquito-borne virus that has been implicated in the surge of the number of microcephaly instances in South America. The recent rapid spread of the virus led to its declaration as a global health emergency by the World Health Organization. The virus is transmitted mainly by the mosquito Aedes aegypti, which is also the vector of dengue virus; however, little is known about the interactions of the virus with the mosquito vector. In this study, we investigated the transcriptome profiles of whole A...
November 2017: MSphere
https://www.readbyqxmd.com/read/29186957/the-human-pegivirus-a-new-name-for-an-ancient-virus-can-transfusion-medicine-come-up-with-something-new
#17
G Marano, M Franchini, B Farina, V Piccinini, S Pupella, S Vaglio, G Grazzini, G M Liumbruno
Human pegivirus (HPgV, formerly called GB virus C/hepatitis G virus) is a poorly understood RNA virus of the Flaviviridae family. The HPgV infection is common worldwide and the virus is likely transmitted by blood products. At this time, no causal association between HPgV and human diseases has been identified. While waiting for new findings to better understand the Pegivirus genus, the aim of our narrative review is to discuss the currently available information on HPgV focusing on its prevalence in blood donors and its potential threat to transfusion safety...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29162867/broad-spectrum-antiviral-agents-secreted-phospholipase-a2-targets-viral-envelope-lipid-bilayers-derived-from-the-endoplasmic-reticulum-membrane
#18
Ming Chen, Chie Aoki-Utsubo, Masanori Kameoka, Lin Deng, Yutaka Terada, Wataru Kamitani, Kei Sato, Yoshio Koyanagi, Makoto Hijikata, Keiko Shindo, Takeshi Noda, Michinori Kohara, Hak Hotta
Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The phospholipid content of the ER membrane differs from that of the plasma membrane (PM). The phospholipase A2 (PLA2) superfamily consists of a large number of members that specifically catalyse the hydrolysis of phospholipids at a particular position...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29153860/the-antimicrobial-peptide-hs-1-inhibits-dengue-virus-infection
#19
Juliana M C Monteiro, Michelle D Oliveira, Roberto S Dias, Lorena Nacif-Marçal, Renato N Feio, Sukarno O Ferreira, Leandro L Oliveira, Cynthia C Silva, Sérgio O Paula
Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. As there is no antiviral drug effective against the DENV, the antiviral activity of a synthetic peptide called HS-1, derived from the secretion of the anuran Hypsiboas semilineatus, has been evaluated. The assays of neutralization in the Vero cells show a complete inhibition of infection of the serotypes 2 and 3...
November 16, 2017: Virology
https://www.readbyqxmd.com/read/29152704/west-nile-disease-in-tunisia-an-overview-of-60-years
#20
Salah Hammami, Thameur Ben Hassine, Annamaria Conte, Jihène Amdouni, Fabrizio De Massis, Soufiène Sghaier, Sonia Ben Hassen
West Nile virus (WNV) is an arthropod borne virus of public health importance. The virus is a member of the genus Flavivirus and belongs to the Japanese encephalitis virus (JEV) antigenic complex under the Flaviviridae family. The WNV is continuously spreading across Tunisia especially in the coastal and Southern area of the country. The first human West Nile disease (WND) epidemic in Tunisia occurred in 1997, since then, the quantity and the extension of spillover effects increased constantly. However, the existing knowledge of factors triggering such events continues to be rather poor...
September 30, 2017: Veterinaria Italiana
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