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https://www.readbyqxmd.com/read/27911897/heterologous-protection-against-asian-zika-virus-challenge-in-rhesus-macaques
#1
Matthew T Aliota, Dawn M Dudley, Christina M Newman, Emma L Mohr, Dane D Gellerup, Meghan E Breitbach, Connor R Buechler, Mustafa N Rasheed, Mariel S Mohns, Andrea M Weiler, Gabrielle L Barry, Kim L Weisgrau, Josh A Eudailey, Eva G Rakasz, Logan J Vosler, Jennifer Post, Saverio Capuano, Thaddeus G Golos, Sallie R Permar, Jorge E Osorio, Thomas C Friedrich, Shelby L O'Connor, David H O'Connor
BACKGROUND: Zika virus (ZIKV; Flaviviridae, Flavivirus) was declared a public health emergency of international concern by the World Health Organization (WHO) in February 2016, because of the evidence linking infection with ZIKV to neurological complications, such as Guillain-Barre Syndrome in adults and congenital birth defects including microcephaly in the developing fetus. Because development of a ZIKV vaccine is a top research priority and because the genetic and antigenic variability of many RNA viruses limits the effectiveness of vaccines, assessing whether immunity elicited against one ZIKV strain is sufficient to confer broad protection against all ZIKV strains is critical...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27893824/analysis-of-synonymous-codon-usage-bias-of-zika-virus-and-its-adaption-to-the-hosts
#2
Hongju Wang, Siqing Liu, Bo Zhang, Wenqiang Wei
Zika virus (ZIKV) is a mosquito-borne virus (arbovirus) in the family Flaviviridae, and the symptoms caused by ZIKV infection in humans include rash, fever, arthralgia, myalgia, asthenia and conjunctivitis. Codon usage bias analysis can reveal much about the molecular evolution and host adaption of ZIKV. To gain insight into the evolutionary characteristics of ZIKV, we performed a comprehensive analysis on the codon usage pattern in 46 ZIKV strains by calculating the effective number of codons (ENc), codon adaptation index (CAI), relative synonymous codon usage (RSCU), and other indicators...
2016: PloS One
https://www.readbyqxmd.com/read/27893666/four-weeks-of-paritaprevir-ritonavir-ombitasvir-plus-dasabuvir-encountering-dengue-fever-resulted-in-sustained-virological-response-in-an-hcv-patient-a-case-report
#3
Chung-Feng Huang, Tyng-Yuan Jang, Po-Liang Lu, Ming-Lung Yu
BACKGROUND: Direct antiviral agent (DAA) has been the standard of care for patients with hepatitis C virus (HCV) infection. Twelve weeks of paritaprevir/ritonavir/ombitasvir plus dasabuvir (PROD) with or without ribavirin has shown to have a sustained virological response at post-treatment 12 weeks (SVR12) rate of >90% in HCV genotype 1 (HCV-1) patients. METHODS: We report a HCV-1b patient who received only 25 days of PROD treatment. RESULTS: The patient early terminated treatment due to dengue fever but eventually achieved SVR12...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27892990/zika-virus-what-the-otolaryngologist-should-know-a-review
#4
Demetri Arnaoutakis, Tapan Padhya
Importance: Initially discovered in 1947, Zika virus infection received little notoriety as a tropical disease until 2015 when an outbreak of microcephaly cases was reported in Brazil. Zika is a single-stranded RNA arbovirus of the Flaviviridae family. The primary source of infection in humans stems from Aedes aegypti mosquito bites but can also occur through sexual, blood, and perinatal transmission. With expectations that 3 to 4 million people across the Americas will be infected over the next year, the World Health Organization has declared this event a Public Health Emergency of International Concern...
November 17, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27878100/neurological-manifestations-of-zika-virus-infection
#5
REVIEW
Ana-Belén Blázquez, Juan-Carlos Saiz
Zika virus (ZIKV) is a flavivirus (Flaviviridae family) transmitted mainly by Aedes mosquitoes. The virus was restricted to the African continent until its spread to south-east Asia in the 1980's, the Micronesia in 2007, the French Polynesia in 2013 and, more recently in the Americas in 2015, where, up to date, the World Health Organization (WHO) has estimated about 3-4 million total cases of ZIKV infection. During outbreaks in the French Polynesia and Brazil in 2013 and 2015, respectively, national health authorities reported potential neurological complications of ZIKV disease, chiefly an upsurge in Guillain-Barré syndrome, which coincided with ZIKV outbreaks...
November 12, 2016: World Journal of Virology
https://www.readbyqxmd.com/read/27872814/transcriptional-profiles-of-wnv-neurovirulence-in-a-genetically-diverse-collaborative-cross-population
#6
Richard Green, Courtney Wilkins, Sunil Thomas, Aimee Sekine, Renee C Ireton, Martin T Ferris, Duncan M Hendrick, Kathleen Voss, Fernando Pardo-Manuel de Villena, Ralph S Baric, Mark T Heise, Michael Gale
West Nile Virus (WNV) is a mosquito-transmitted virus from the Flaviviridae family that causes fever in 1 in 5 infected people. WNV can also become neuro-invasive and cross the blood-brain barrier leading to severe neurological symptoms in a subset of WNV infected individuals [1]. WNV neuro-invasion is believed to be influenced by a number of factors including host genetics. In order to explore these effects and recapitulate the complex immune genetic differences among individuals, we studied gene expression following WNV infection in the Collaborative Cross (CC) model...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27867910/intrinsically-disordered-side-of-the-zika-virus-proteome
#7
Rajanish Giri, Deepak Kumar, Nitin Sharma, Vladimir N Uversky
Over the last few decades, concepts of protein intrinsic disorder have been implicated in different biological processes. Recent studies have suggested that intrinsically disordered proteins (IDPs) provide structural plasticity and functional diversity to viral proteins that are involved in rapid replication and immune evasion in host cells. In case of Zika virus, the roles of protein intrinsic disorder in mechanisms of pathogenesis are not completely understood. In this study, we have analyzed the prevalence of intrinsic disorder in Zika virus proteome (strain MR 766)...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/27862959/understanding-zika-virus
#8
John S Murray
PURPOSE: This article describes what pediatric healthcare professionals should know about Zika virus (ZIKV). LITERATURE REVIEW: ZIKV is classified as an arthropod-borne, single-stranded RNA virus of the Flaviviridae family and genus Flavivirus. ZIKV is not new. The virus was first discovered almost 70 years ago in Uganda. The first isolate of the virus was found in rhesus monkeys in the Zika Forrest, hence the nomenclature. The primary route of ZIKV transmission to humans is through the bite of an infected Aedes species mosquito-primarily Aedes aegypti...
November 9, 2016: Journal for Specialists in Pediatric Nursing: JSPN
https://www.readbyqxmd.com/read/27858969/zika-virus-quantification-propagation-detection-and-storage
#9
Darrell S Agbulos, Larissa Barelli, Bryan V Giordano, Fiona F Hunter
Zika virus (ZIKV), belonging to the family Flaviviridae, genus Flavivirus, is an arthropod-borne virus that was first discovered from the Zika forest in Uganda in 1947. Recent outbreaks in South America have linked ZIKV to cases of microcephaly and Guillain-Barré syndrome in humans. With the increased interest in ZIKV, protocols must be established to facilitate proper research. Here we describe the laboratory techniques required to quantify, propagate, and store ZIVK. We also review the proper safety protocol for the handling of ZIKV, which is classified as a Biosafety Level 2 pathogen by the United States Centers for Disease Control and Prevention...
November 18, 2016: Current Protocols in Microbiology
https://www.readbyqxmd.com/read/27853992/progress-towards-understanding-the-pathogenesis-of-dengue-hemorrhagic-fever
#10
REVIEW
Xiaojing Pang, Rudian Zhang, Gong Cheng
Dengue virus (DENV) is a mosquito-borne virus belonging to the Flaviviridae family. There are 4 serotypes of DENV that cause human disease through transmission by mosquito vectors. DENV infection results in a broad spectrum of clinical symptoms, ranging from mild fever to dengue hemorrhagic fever (DHF), the latter of which can progress to dengue shock syndrome (DSS) and death. Researchers have made unremitting efforts over the last half-century to understand DHF pathogenesis. DHF is probably caused by multiple factors, such as virus-specific antibodies, viral antigens and host immune responses...
November 14, 2016: Virologica Sinica
https://www.readbyqxmd.com/read/27834141/in-vitro-exploration-of-the-anti-hcv-potential-of-the-synthetic-spacer-peptides-derived-from-human-bovine-and-camel-lactoferrins
#11
Abdulgader H Albar, Esmail M El-Fakharany, Hussein A Almehdar, Vladimir N Uversky, Elrashdy M Redwan
Chronic liver disease is often associated with the infection by hepatitis C virus (HCV), which is an enveloped RNA virus belonging to the Flaviviridae family. Many studies found that milk proteins, such as lactoferrin, might have profound antiviral activity against HCV. Various secretory fluids ranging from milk, to tears, saliva, and nasal secretion, and to bile and pancreatic juice, as well as neutrophils, mucosal surfaces, and blood contain a widely spread multifunctional glycoprotein, lactoferrin (Lf), structure of which can be depicted as two homologous domains connected by the short spacer peptide...
November 11, 2016: Protein and Peptide Letters
https://www.readbyqxmd.com/read/27818091/mosquito-transmitted-viruses-the-great-brazilian-challenge
#12
REVIEW
Mânlio Tasso de Oliveira Mota, Ana Carolina Terzian, Maria Luana Cristiny Rodrigues Silva, Cássia Estofolete, Maurício Lacerda Nogueira
Arboviruses pose a serious threat to public health worldwide, overloading the healthcare system and causing economic losses. These viruses form a very diverse group, and in Brazil, arboviruses belonging to the families Flaviviridae and Togaviridae are predominant. Unfortunately, the number of arboviruses increases in proportion with factors such as deforestation, poor sanitation, climate changes, and introduction of new viruses like Chikungunya virus and Zika virus. In Brazil, dengue is endemic, along with the presence of other arboviruses...
October 27, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27812646/one-year-after-the-zika-virus-outbreak-in-brazil-from-hypotheses-to-evidence
#13
Carlos Alexandre Antunes de Brito, Marli Tenorio Cordeiro
Zika virusis an arbovirus of the Flaviviridae family with two major strains, an Asian and an African strain. The main vectors involved in the transmission of Zika virus are the Aedes aegypti and Aedes albopictus mosquitoes. Despite its identification, discovered in 1947 in the Zika forest in Uganda, only isolated and sporadic occurrences of human infection were reported within a largely asymptomatic proportion of individuals. The first reported outbreak occurred in 2007 in the Yap Island, which belongs to the Federated States of Micronesia in the Pacific Ocean, and in French Polynesia, where high attack rates occurred and the first cases of associated Guillain-Barré syndrome were reported...
September 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27812357/emergence-and-spreading-potential-of-zika-virus
#14
REVIEW
Álvaro Fajardo, Juan Cristina, Pilar Moreno
Zika virus (ZIKV) is an arthropod-borne Flavivirus (family Flaviviridae) closely related to dengue, yellow fever and West Nile viruses. ZIKV remained neglected, confined to enzootic transmission cycles in Africa and Asia, until the first significant outbreak was reported in Micronesia in 2007. Subsequent epidemics of growing incidence occurred in French Polynesia and other South Pacific Islands, and recently, in the Americas. The latter and currently ongoing outbreak of unprecedented incidence revealed the association of ZIKV infection with the occurrence of severe congenital malformations and neurological diseases, leading to a widespread concern about its potential to pose a global public health threat...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27807228/tim-1-promotes-hepatitis-c-virus-cell-attachment-and-infection
#15
Jing Wang, Luhua Qiao, Zhouhua Hou, Guangxiang Luo
: Human TIM and TAM family proteins were recently found to serve as phosphatidylserine receptors which promote infection of many different viruses including dengue virus, West Nile virus, Ebola virus, Marburg virus, and Zika virus. In the present study, we provide substantial evidence demonstrating that TIM-1 is important for efficient infection of hepatitis C virus (HCV). The knockdown of TIM-1 expression significantly reduced HCV infection but not HCV RNA replication. Likewise, TIM-1 knockout in Huh-7...
November 2, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27800692/waiting-in-the-wings-the-potential-of-mosquito-transmitted-flaviviruses-to-emerge
#16
Duncan R Smith
The sudden dramatic emergence of the mosquito transmitted flavivirus Zika virus has bought to the world's attention a relatively obscure virus that was previously only known to specialist researchers. The genus Flavivirus of the family Flaviviridae contains a number of well-known mosquito transmitted human pathogenic viruses including the dengue, yellow fever, Japanese encephalitis and West Nile viruses. However, the genus also contains a number of lesser known human pathogenic viruses transmitted by mosquitoes including Wesselsbron virus, Ilheus virus, St...
November 1, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27795432/development-and-characterization-of-recombinant-virus-generated-from-a-new-world-zika-virus-infectious-clone
#17
James Weger-Lucarelli, Nisha K Duggal, Kristen Bullard-Feibelman, Milena Veselinovic, Hannah Romo, Chilinh Nguyen, Claudia Rückert, Aaron C Brault, Richard A Bowen, Mark Stenglein, Brian J Geiss, Gregory D Ebel
: Zika virus (ZIKV; Family Flaviviridae, genus Flavivirus) is a rapidly expanding global pathogen that has been associated with severe clinical manifestations, including devastating neurological disease in infants. There are currently no molecular clones of a New World ZIKV available, hindering progress toward understanding determinants of transmission and pathogenesis. Here we report the development and characterization of a novel ZIKV reverse genetics system based on a 2015 isolate from Puerto Rico (PRVABC59)...
October 19, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27788396/in-silico-analysis-of-hepatitis-c-virus-hcv-polyprotein-domains-and-their-comparison-with-other-pathogens-and-allergens-to-gain-insight-on-pathogenicity-mechanisms
#18
Seema Patel
Hepatitis C (HCV) is a deadly virus from family Flaviviridae, causing acute or chronic liver inflammation. Given its lethality and no known vaccine to curb it, understanding its pathogenic mechanism is critical. By analyzing the domains in its protein sequence, a plethora can be learnt about its immune manipulation strategies. In this regard, current in silico study compares publicly-available HCV polyprotein sequences and their domain profiles. Apart from using UniProt sequences and SMART (Simple modular architecture research tool) platform for domain profiling, a set of customized scripts were developed to extract the patterns of protein domain distribution...
October 15, 2016: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/27783679/vector-competence-of-american-mosquitoes-for-three-strains-of-zika-virus
#19
James Weger-Lucarelli, Claudia Rückert, Nunya Chotiwan, Chilinh Nguyen, Selene M Garcia Luna, Joseph R Fauver, Brian D Foy, Rushika Perera, William C Black, Rebekah C Kading, Gregory D Ebel
In 2015, Zika virus (ZIKV; Flaviviridae; Flavivirus) emerged in the Americas, causing millions of infections in dozens of countries. The rapid spread of the virus and the association with disease outcomes such as Guillain-Barré syndrome and microcephaly make understanding transmission dynamics essential. Currently, there are no reports of vector competence (VC) of American mosquitoes for ZIKV isolates from the Americas. Further, it is not clear whether ZIKV strains from other genetic lineages can be transmitted by American Aedes aegypti populations, and whether the scope of the current epidemic is in part facilitated by viral factors such as enhanced replicative fitness or increased vector competence...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27773535/n6-methyladenosine-in-flaviviridae-viral-rna-genomes-regulates-infection
#20
Nandan S Gokhale, Alexa B R McIntyre, Michael J McFadden, Allison E Roder, Edward M Kennedy, Jorge A Gandara, Sharon E Hopcraft, Kendra M Quicke, Christine Vazquez, Jason Willer, Olga R Ilkayeva, Brittany A Law, Christopher L Holley, Mariano A Garcia-Blanco, Matthew J Evans, Mehul S Suthar, Shelton S Bradrick, Christopher E Mason, Stacy M Horner
The RNA modification N6-methyladenosine (m(6)A) post-transcriptionally regulates RNA function. The cellular machinery that controls m(6)A includes methyltransferases and demethylases that add or remove this modification, as well as m(6)A-binding YTHDF proteins that promote the translation or degradation of m(6)A-modified mRNA. We demonstrate that m(6)A modulates infection by hepatitis C virus (HCV). Depletion of m(6)A methyltransferases or an m(6)A demethylase, respectively, increases or decreases infectious HCV particle production...
November 9, 2016: Cell Host & Microbe
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