keyword
MENU ▼
Read by QxMD icon Read
search

Flaviviridae

keyword
https://www.readbyqxmd.com/read/28531943/recent-trends-in-zikv-research-a-step-away-from-cure
#1
REVIEW
Aftab Alam, Nikhat Imam, Anam Farooqui, Shahnawaz Ali, Md Zubbair Malik, Romana Ishrat
Zika virus (ZikV) is a member of the Flaviviridae virus family, genus Flavivirus has emerged as a potential threat to human health worldwide. Consequences of vertical infections includes microcephaly with brain and eye anomalies, and adult infections includes Guillain-Barrésyndrome (GBS), brain ischemia, myelitis and meningoencephalitis. To develop a better treatment, many efforts are being made, like drug-repurposing concept for FDA-approved drugs for antiviral activity are screened against ZikV infection and emerging as a promising alternative to expedite drug development and various vaccines like DNA, ZPIV, LAIV, mRNA and AGS-v vaccines have been designed and in under clinical trial phases...
May 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28516037/zika-virus-infection-in-a-newly-married-greek-couple
#2
Petros Ioannou, Stella Soundoulounaki, Nikolaos Spernovasilis, Elpida Papadopoulou, Anna Papa, Achilleas Gikas
Zika virus (ZIKV) is a member of the Flaviviridae family causing asymptomatic or mildly symptomatic infections with fever, rash, arthralgia and headache. It is transmitted by the Aedes species mosquitoes and also sexually and transplacentally, and has been recently associated with congenital neurologic birth defects in South and Central America. We report the case of a newly married couple from Greece who travelled to Cuba for their honeymoon and developed mild symptoms consistent with arboviral infection. After returning to Greece, they were found to have been infected by Zika virus during their honeymoon...
2017: IDCases
https://www.readbyqxmd.com/read/28502333/zika-virus-epidemiology-pathogenesis-and-human-disease
#3
REVIEW
Elizabeth K Nugent, Anne K Nugent, Rebecca Nugent, Kenneth Nugent
The Zika virus is a positive sense, single-stranded RNA arbovirus in the Flaviviridae family, genus Flavivirus. This virus was initially isolated in Africa and is transmitted to nonhuman primates and humans by mosquitoes. Initial reports describe sporadic mild viral infection with fever, arthralgia, myalgia and conjunctivitis in Africa and Asia. However, its geographic distribution has significantly increased, and it has caused large outbreaks in the Yap Islands in 2007, in French Polynesia in 2013 and in Brazil in 2015...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28501619/a-label-free-immunoassay-for-flavivirus-detection-by-the-reflective-phantom-interface-technology
#4
Giovanni Tagliabue, Valentina Faoro, Serena Rizzo, Daniele Sblattero, Andrea Saccani, Gabriele Riccio, Tommaso Bellini, Matteo Salina, Marco Buscaglia, Alessandro Marcello
Members of Flaviviridae are widespread and cause clinically relevant arboviral diseases that impact locally and as imported travel-related infections. Direct detection of viraemia is limited, being typically undetectable at onset of symptoms. Therefore, diagnosis is primarily based on serology, which is complicated by high cross-reactivity across different species. The overlapping geographical distribution of the vectors in areas with a weak healthcare system, the increase of international travel and the similarity of symptoms highlight the need for rapid and reliable multi-parametric diagnostic tests in point-of-care formats...
May 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28500817/transmission-incompetence-of-culex-quinquefasciatus-and-culex-pipiens-pipiens-from-north-america-for-zika-virus
#5
Joan L Kenney, Hannah Romo, Nisha K Duggal, Wen-Pin Tzeng, Kristen L Burkhalter, Aaron C Brault, Harry M Savage
AbstractIn late 2014, Zika virus (ZIKV; Flaviviridae, Flavivirus) emerged as a significant arboviral disease threat in the Western hemisphere. Aedes aegypti and Aedes albopictus have been considered the principal vectors of ZIKV in the New World due to viral isolation frequency and vector competence assessments. Limited reports of Culex transmission potential have highlighted the need for additional vector competence assessments of North American Culex species. Accordingly, North American Culex pipiens and Culex quinquefasciatus were orally exposed and intrathoracically inoculated with the African prototype ZIKV strain and currently circulating Asian lineage ZIKV strains to assess infection, dissemination, and transmission potential...
May 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28498740/powassan-virus-an-emerging-arbovirus-of-public-health-concern-in-north-america
#6
Meghan E Hermance, Saravanan Thangamani
Powassan virus (POWV, Flaviviridae) is the only North American member of the tick-borne encephalitis serogroup of flaviviruses. It is transmitted to small- and medium-sized mammals by Ixodes scapularis, Ixodes cookei, and several other Ixodes tick species. Humans become infected with POWV during spillover transmission from the natural transmission cycles. In humans, POWV is the causative agent of a severe neuroinvasive illness with 50% of survivors displaying long-term neurological sequelae. POWV was recognized as a human pathogen in 1958 when a young boy died of severe encephalitis in Powassan, Ontario, and POWV was isolated from the brain autopsy of this case...
May 12, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28474402/detection-of-border-disease-virus-in-mexican-cattle
#7
N Gómez-Romero, F J Basurto-Alcántara, A Verdugo-Rodríguez, R Lagunes-Quintanilla, F V Bauermann, J F Ridpath
The genus Pestivirus within Flaviviridae is comprised of four recognized species, namely, bovine viral diarrhoea virus 1 (BVDV-1), bovine viral diarrhoea virus 2 (BVDV-2), border disease virus (BDV) and classical swine fever virus (CSFV). BDV, while primarily infecting sheep and goats, has also been reported in cattle and wild animals. Infections of sheep and goats result in economic loss due to abortions and the birth of persistently infected animals that have poor production and reduced life expectancy. In this study, we report the detection of BDV in cattle serum collected as part of pestivirus surveillance programme from six regions of Mexico, where a 67...
May 4, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28473813/asunaprevir-evokes-hepatocytes-innate-immunity-to-restrict-the-replication-of-hepatitis-c-and-dengue-virus
#8
Wei-Lun Tsai, Jin-Shiung Cheng, Chih-Wen Shu, Kwok-Hung Lai, Hoi-Hung Chan, Chun-Ching Wu, Jing-Mei Wu, Ping-I Hsu, Raymond T Chung, Tsung-Hsien Chang
Type I Interferon-mediated innate immunity against Flaviviridae, such as Hepatitis C virus (HCV) and Dengue virus (DENV), involves TLR3, RIG-I-like receptor (RLR) and JAK-STAT signal pathways. Asunaprevir is a newly developed HCV protease inhibitor for HCV treatment. Whether, asunaprevir activates innate immunity to restrict viral infection is unclear. Thus, this study investigates the effect of asunaprevir on innate immunity and its influence on HCV and DENV infection. Huh 7.5.1, Hep-G2 cells, JFH-1 infection model, and DENV-2 infection were used for the analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28470955/phenotypic-characterisation-of-cell-populations-in-the-brains-of-horses-experimentally-infected-with-west-nile-virus
#9
G H Delcambre, J Liu, W J Streit, G P J Shaw, K Vallario, J Herrington, N Wenzlow, K L Barr, M T Long
BACKGROUND: West Nile Virus (WNV), a mosquito borne member of the Flaviviridae, is one of the most commonly diagnosed agents of viral encephalitis in horses and people worldwide. OBJECTIVE: A cassette of markers for formalin-fixed paraffin-embedded (FFPE) tissue and an archive of tissues from experimental infections in the horse were used to investigate the equine neuroimmune response to WNV meningoencephalomyelitis to phenotype the early response to WNV infection in the horse...
May 4, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28461069/characterization-of-the-zika-virus-two-component-ns2b-ns3-protease-and-structure-assisted-identification-of-allosteric-small-molecule-antagonists
#10
Sergey A Shiryaev, Chen Farhy, Antonella Pinto, Chun-Teng Huang, Nicole Simonetti, Annie Elong Ngono, Antimone Dewing, Sujan Shresta, Anthony B Pinkerton, Piotr Cieplak, Alex Y Strongin, Alexey V Terskikh
The recent re-emergence of Zika virus (ZIKV)(1), a member of the Flaviviridae family, has become a global emergency. Currently, there are no effective methods of preventing or treating ZIKV infection, which causes severe neuroimmunopathology and is particularly harmful to the developing fetuses of infected pregnant women. However, the pathology induced by ZIKV is unique among flaviviruses, and knowledge of the biology of other family members cannot easily be extrapolated to ZIKV. Thus, structure-function studies of ZIKV proteins are urgently needed to facilitate the development of effective preventative and therapeutic agents...
April 29, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28447317/neuroimaging-findings-of-postnatally-acquired-zika-virus-infection-a-pictorial-essay
#11
Mohammad Zare Mehrjardi, Guillaume Carteaux, Andrea Poretti, Morteza Sanei Taheri, Sonia Bermudez, Heron Werner, Luiz Celso Hygino da Cruz
Zika virus (ZIKV) is a mosquito-borne arbovirus from the Flaviviridae family, first discovered in 1947. There has been no report of severe complications caused by this virus in humans until recently. However, it is confirmed now that prenatally acquired ZIKV infection may cause severe congenital brain abnormalities in the infected fetuses. In addition, there has been an increasing number of reports during recent years about the causal relationship between postnatally acquired ZIKV infection and severe neurologic complications (mostly immune-mediated ones)...
April 26, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28433396/lambs-are-susceptible-to-experimental-challenge-with-spanish-goat-encephalitis-virus
#12
L M Salinas, R Casais, J F García Marín, K P Dalton, L J Royo, A Del Cerro, E Gayo, M P Dagleish, R A Juste, A Balseiro
Spanish goat encephalitis virus (SGEV) is a member of the genus Flavivirus, family Flaviviridae, and causes encephalomyelitis in goats. The aim of this study was to determine whether sheep are susceptible to experimental challenge with SGEV by two different routes. The results show that SGEV can infect sheep by both the subcutaneous and intravenous routes, resulting in neurological clinical disease with extensive and severe histological lesions in the central nervous system. Lambs challenged subcutaneously developed more severe lesions on the ipsilateral side of the brain, but the lesion morphology was similar irrespective of the route of challenge...
April 19, 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28433051/insect-specific-viruses-a-historical-overview-and-recent-developments
#13
Christopher M Roundy, Sasha R Azar, Shannan L Rossi, Scott C Weaver, Nikos Vasilakis
Arthropod-borne viruses (arboviruses) have in recent years become a tremendous global health concern resulting in substantial human morbidity and mortality. With the widespread utilization of molecular technologies such as next-generation sequencing and the advancement of bioinformatics tools, a new age of viral discovery has commenced. Many of the novel agents being discovered in recent years have been isolated from mosquitoes and exhibit a highly restricted host range. Strikingly, these insect-specific viruses have been found to be members of viral families traditionally associated with human arboviral pathogens, including but not limited to the families Flaviviridae, Togaviridae, Reoviridae, and Bunyaviridae...
2017: Advances in Virus Research
https://www.readbyqxmd.com/read/28413745/seven-cases-of-zika-virus-infection-in-south-florida
#14
Waqaar Khawar, Romina Bromberg, Molly Moor, Natalya Lyubynska, Hilda Mahmoudi
INTRODUCTION: Zika virus, an arbovirus of the Flaviviridae family, is a mosquito-borne virus known to cause microcephaly through vertical transmission. Infection presents with mild, self-limiting symptoms. Currently, a Zika virus outbreak has spread across most of South and Central America. Travel-related and sexually transmitted cases have been reported across the United States. However, the vector-borne transmission has been limited to Florida and Texas. We present seven cases of Zika virus infection that presented at a single institution in South Florida...
March 16, 2017: Curēus
https://www.readbyqxmd.com/read/28411164/high-levels-of-local-inter-and-intra-host-genetic-variation-of-west-nile-virus-and-evidence-of-fine-scale-evolutionary-pressures
#15
Dylan J Ehrbar, Kiet A Ngo, Scott R Campbell, Laura D Kramer, Alexander T Ciota
West Nile virus (WNV; Flaviviridae, Flavivirus) has been endemic in New York State (NYS) since its 1999 introduction, yet prevalence in Culex mosquitoes varies substantially over small spatial and temporal scales. It is unclear if viral genetics plays a role in this variability, as genetic and phenotypic characterization on local scales has generally been lacking. In addition, intrahost diversity of circulating strains have not been fully characterized despite the documented role of minority variants in viral fitness and virulence...
April 12, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28404849/quantitative-proteomic-analysis-of-mosquito-c6-36-cells-reveals-host-proteins-involved-in-zika-virus-infection
#16
Qi-Lin Xin, Cheng-Lin Deng, Xi Chen, Jun Wang, Shao-Bo Wang, Wei Wang, Fei Deng, Bo Zhang, Gengfu Xiao, Lei-Ke Zhang
Zika virus (ZIKV) is an emerging arbovirus belonging to the genus Flavivirus of the family Flaviviridae During replication processes, flavivirus will manipulate host cell systems to facilitate their replication, while the host cells will activate antiviral responses. Identification of host proteins involved in flavivirus replication process may lead to the discovery of antiviral targets. Mosquito Aedes aegypti and Aedes albopictus are epidemiologically important vectors for ZIKV, and effective restrictions of ZIKV replication in mosquitoes will be vital in controlling the spread of virus...
April 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28357156/does-zika-virus-cause-microcephaly-applying-the-bradford-hill-viewpoints
#17
Asma Awadh, Abrar Ahmad Chughtai, Amalie Dyda, Mohamud Sheikh, David J Heslop, Chandini Raina MacIntyre
INTRODUCTION: Zika virus has been documented since 1952, but been associated with mild, self-limiting disease. Zika virus is classified as an arbovirus from a family of Flaviviridae and primarily spread by Aedes Aegypti mosquitos. However, in a large outbreak in Brazil in 2015, Zika virus has been associated with microcephaly. METHODS: In this review we applied the Bradford-Hill viewpoints  to investigate the association between Zika virus and microcephaly. We examined historical studies, available data and also compared historical rates of microcephaly prior to the Zika virus outbreak...
February 22, 2017: PLoS Currents
https://www.readbyqxmd.com/read/28339489/human-subtilisin-kexin-isozyme-1-ski-1-site-1-protease-s1p-regulates-cytoplasmic-lipid-droplet-abundance-a-potential-target-for-indirect-acting-anti-dengue-virus-agents
#18
Anastasia Hyrina, Fanrui Meng, Steven J McArthur, Sharlene Eivemark, Ivan R Nabi, François Jean
Viral hijacking and manipulation of host-cell biosynthetic pathways by human enveloped viruses are shared molecular events essential for the viral lifecycle. For Flaviviridae members such as hepatitis C virus and dengue virus (DENV), one of the key subsets of cellular pathways that undergo manipulation is the lipid metabolic pathways, underlining the importance of cellular lipids and, in particular, lipid droplets (LDs) in viral infection. Here, we hypothesize that targeting cellular enzymes that act as key regulators of lipid homeostasis and LD formation could represent a powerful approach to developing a novel class of broad-spectrum antivirals against infection associated with all DENV serotypes (1-4) circulating around the world...
2017: PloS One
https://www.readbyqxmd.com/read/28338950/nonreplicative-rna-recombination-of-an-animal-plus-strand-rna-virus-in-the-absence-of-efficient-translation-of-viral-proteins
#19
Maximiliane Kleine Büning, Denise Meyer, Sophia Austermann-Busch, Gleyder Roman-Sosa, Tillmann Rümenapf, Paul Becher
RNA recombination is a major driving force for the evolution of RNA viruses and is significantly implicated in the adaptation of viruses to new hosts, changes of virulence, as well as in the emergence of new viruses including drug-resistant and escape mutants. However, the molecular details of recombination in animal RNA viruses are only poorly understood. In order to determine whether viral RNA recombination depends on translation of viral proteins, a nonreplicative recombination system was established which is based on cotransfection of cells with synthetic bovine viral diarrhea virus (family Flaviviridae) RNA genome fragments either lacking the internal ribosome entry site required for cap-independent translation or lacking almost the complete polyprotein coding region...
April 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/28338754/spatial-quantification-of-the-world-population-potentially-exposed-to-zika-virus
#20
Alberto J Alaniz, Antonella Bacigalupo, Pedro E Cattan
Background: Zika virus is an emerging Flaviviridae virus, which has spread rapidly in the last few years. It has raised concern because it has been associated with fetus microcephaly when pregnant women are infected. The main vector is the mosquito Aedes aegypti , distributed in tropical areas. Methods: Niche modelling techniques were used to estimate the potential distribution area of A. aegypti. This was overlapped with human population density, determining areas of potential transmission risk worldwide...
February 23, 2017: International Journal of Epidemiology
keyword
keyword
117114
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"