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https://www.readbyqxmd.com/read/29651535/cell-cycle-of-the-enamel-knot-during-tooth-morphogenesis
#1
Seo-Yoon Jung, David William Green, Han-Sung Jung, Eun-Jung Kim
Enamel knot (EK) is known to be a central organ in tooth development, especially for cusp patterning. To trace the exact position and movement among the inner dental epithelium (IDE) and EK cells, and to monitor the relationship between the EK and cusp patterning, it is essential that we understand the cell cycle status of the EK in early stages of tooth development. In this study, thymidine analogous (IdU, BrdU) staining was used to evaluate the cell cycle phase of the primary EK at the early casp stage (E13...
April 12, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29621961/antegrade-balloon-dilatation-as-a-treatment-option-for-posttransplant-ureteral-strictures-case-series-of-50-patients
#2
Liselotte S S Ooms, Adriaan Moelker, Joke I Roodnat, Jan N M Ijzermans, Mirza M Idu, Turkan Terkivatan
OBJECTIVES: The aim of this study was to investigate the effects of antegrade balloon dilatation on ureteral strictures that developed after kidney transplant. MATERIALS AND METHODS: The hospital databases of the Erasmus Medical Center (Rotterdam, The Netherlands) and the Academic Medical Center (Amsterdam, The Netherlands) were retrospectively screened for patients who underwent balloon dilatation after kidney transplant. Balloon dilatation was technically successful whenever it was able to pass the strictured segment with the guidewire followed by balloon inflation; the procedure was clinically successful if no further interventions (for example, surgical revision of the ureteroneocystostomy or prolonged double J placement) were necessary...
April 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29601405/high-risk-prescription-opioid-use-among-people-living-with-hiv
#3
Chelsea E Canan, Geetanjali Chander, Anne K Monroe, Kelly A Gebo, Richard D Moore, Allison L Agwu, G Caleb Alexander, Bryan Lau
BACKGROUND: Prescription opioid use is greater among people living with HIV (PLWH), yet little is known about the prevalence of specific types of high-risk use among these individuals. SETTING: We analyzed clinical and demographic data from the HIV Research Network (HIVRN) and prescribing data from Medicaid for non-cancer patients seeking HIV treatment at four urban clinics between 2006-2010. METHODS: HIVRN patients were included in the analytic sample if they received at least one incident opioid prescription...
March 27, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29540503/a-niche-of-trophoblast-progenitor-cells-identified-by-integrin-%C3%AE-2-is-present-in-first-trimester-human-placentas
#4
Cheryl Q E Lee, Margherita Turco, Lucy Gardner, Benjamin Simons, Myriam Hemberger, Ashley Moffett
During pregnancy the trophoblast cells of the placenta are the only fetal cells in direct contact with maternal blood and decidua. Their functions include transport of nutrients and oxygen, secretion of pregnancy hormones, remodelling the uterine arteries, and communicating with maternal cells. Despite the importance of trophoblast cells in placental development and successful pregnancy, little is known about the identity, location and differentiation of human trophoblast progenitors. We identify a proliferative trophoblast niche at the base of the cytotrophoblast cell columns in first trimester placentas that is characterised by integrin α2 (ITGA2) expression...
March 14, 2018: Development
https://www.readbyqxmd.com/read/29482150/identifying-injection-drug-use-and-estimating-population-size-of-people-who-inject-drugs-using-healthcare-administrative-datasets
#5
Naveed Zafar Janjua, Nazrul Islam, Margot Kuo, Amanda Yu, Stanley Wong, Zahid A Butt, Mark Gilbert, Jane Buxton, Nuria Chapinal, Hasina Samji, Mei Chong, Maria Alvarez, Jason Wong, Mark W Tyndall, Mel Krajden
BACKGROUND: Large linked healthcare administrative datasets could be used to monitor programs providing prevention and treatment services to people who inject drugs (PWID). However, diagnostic codes in administrative datasets do not differentiate non-injection from injection drug use (IDU). We validated algorithms based on diagnostic codes and prescription records representing IDU in administrative datasets against interview-based IDU data. METHODS: The British Columbia Hepatitis Testers Cohort (BC-HTC) includes ∼1...
February 23, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29482055/predictors-of-injecting-cessation-among-a-cohort-of-people-who-inject-drugs-in-tijuana-mexico
#6
Danielle Horyniak, Steffanie A Strathdee, Brooke S West, Meredith Meacham, Gudelia Rangel, Tommi L Gaines
INTRODUCTION: Little is known about the cessation of injecting drug use (IDU) among people who inject drugs (PWID) in low and middle-income settings, where access to effective interventions for reducing drug use (e.g., opioid substitution treatment; OST), may be limited. We measured the incidence and identified predictors of IDU cessation among a cohort of PWID in Tijuana, Mexico. METHODS: Data were drawn from 621 participants in Proyecto El Cuete IV, a prospective cohort of PWID recruited in 2011 and interviewed biannually to 2016...
February 21, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29461241/measurement-of-personal-risk-behavi-or-in-occupational-risk-studies-among-health-care-workers
#7
M Butsashvili, G Kamkamidze, M Kajaia, K Nelson, W Triner, L A McNutt
Risky behaviours, particularly illegal and heavily stigmatized behaviours, are difficult to measure through self-report in both high risk groups and the general population. Underreporting can result in substantially biased estimates of non-injection drug use (IDU) risk of hepatitis C virus (HCV) infection. We hypothesized that asking about the existence of social networks injection drug use may be a useful marker of IDU. A cross-sectional survey of physicians and nurses was conducted in seven hospitals in Georgia...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29460087/prescription-changes-during-geriatric-care-episodes-a-trend-analysis-conducted-in-sweden
#8
Marianne Reimers, Maria Eriksdotter, Åke Seiger, Johan Fastbom
BACKGROUND: The number of drugs prescribed for old people has been rising in recent decades. With increasing age and multiple medications, the risk of complications and drug prescription complexity increases. Multiple changes to prescriptions could be a factor that improves treatment quality. OBJECTIVES: Our objective was to investigate trends in drug prescriptions and factors that contribute to prescription changes. Specific objectives were to find out whether high numbers of prescription changes are significantly correlated with age, sex, comorbidity, length of care episode, and number of drugs...
February 19, 2018: Drugs & Aging
https://www.readbyqxmd.com/read/29447300/explaining-suicide-attempt-with-personality-traits-of-aggression-and-impulsivity-in-a-high-risk-tribal-population-of-india
#9
Piyoosh Kumar Singh, V R Rao
INTRODUCTION: Suicide is a spectrum of behavior including suicide ideation and suicidal attempt and is undoubtedly the outcome of the interaction of several factors. The role of two main constructs of human nature, aggression and impulsivity, has been discussed broadly in relation to suicide, as endophenotypes or traits of personality, in research and in clinical practice across diagnoses. The objective of our study was to assess impulsive and aggressive behaviors among primitive people of the Idu Mishmi tribe, who are known for high suicide completer and attempter rates...
2018: PloS One
https://www.readbyqxmd.com/read/29445897/brdu-edu-dual-labeling-to-determine-the-cell-cycle-dynamics-of-defined-cellular-subpopulations
#10
Lachlan Harris, Oressia Zalucki, Michael Piper
Measuring the mean duration of synthesis-phase (T s ) and of the total cell-cycle (T c ) within progenitor cell populations can provide important insights into the biology governing these cells. Rather than a passive process that shows little variability across cellular contexts, the cell-cycle is instead highly regulated. For example, in the rodent forebrain, T s is selectively lengthened in radial glial progenitor cells undergoing symmetric versus asymmetric division. This lengthening is thought to minimize the potential for copying errors that can occur during DNA replication...
February 14, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29429421/epidemiology-and-risk-factors-for-hepatitis-c-virus-infection-in-a-high-prevalence-population
#11
M A Fill, L A Sizemore, M Rickles, K C Cooper, C M Buecker, H L Mullins, M G Hofmeister, W E Abara, M A Foster, A K Asher, W Schaffner, J R Dunn, T F Jones, C Wester
To understand increasing rates of hepatitis C virus (HCV) infection in Tennessee, we conducted testing, risk factor analysis and a nested case-control study among persons who use drugs. During June-October 2016, HCV testing with risk factor assessment was conducted in sexually transmitted disease clinics, family planning clinics and an addiction treatment facility in eastern Tennessee; data were analysed by using multivariable logistic regression. A nested case-control study was conducted to assess drug-using risks and behaviours among persons who reported intranasal or injection drug use (IDU)...
February 12, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29419568/recent-abacavir-use-increases-risk-for-types-1-and-2-myocardial-infarctions-among-adults-with-hiv
#12
Richard A Elion, Keri N Althoff, Jinbing Zhang, Richard D Moore, Stephen J Gange, Mari M Kitahata, Heidi M Crane, Daniel R Drozd, James H Stein, Marina B Klein, Joseph J Eron, Michael J Silverberg, William C Mathews, Amy C Justice, Timothy R Sterling, Charles S Rabkin, Angel M Mayor, Daniel B Klein, Michael A Horberg, Ronald J Bosch, Oghenowede Eyawo, Frank J Palella
BACKGROUND: There is persistent confusion as to whether abacavir (ABC) increases the risk for myocardial infarction (MI), and whether such risk differs by Type 1 (T1MI) or 2 (T2MI) MI in adults with HIV. METHODS: Incident MIs in NA-ACCORD participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude (HR) and adjusted hazard ratios (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately...
February 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29415660/transmission-dynamics-for-methicilin-resistant-staphalococous-areus-with-injection-drug-user
#13
Rebekah Wagner, Folashade B Agusto
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen resistance to antibiotics including methicillin. The resistance first emerged in 1960 in a healthcare setting only after two years of using methicillin as a viable treatment for methicillin-susceptible Staphylococcus aureus. MRSA leads to infections in different parts of the body including the skin, bloodstream, lungs, or the urinary tract. METHODS: A deterministic model for methicillin-resistant Staphylococcus aureus (MRSA) with injection drug users is designed...
February 7, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29397766/trends-in-discharges-from-the-hiv-aids-ward-at-a-tertiary-canadian-hospital-from-2005-to-2014
#14
Denise Jaworsky, Peter Phillips, Zishan Cui, William Chau, Guillaume Colley, Raja Dutta, Benita Yip, Hayden Kremer, Oghenowede Eyawo, Julio Sg Montaner, Mark W Hull
Advances in HIV therapies have transformed HIV infection into a manageable chronic disease. Accordingly, hospital admission trends among people living with HIV may have evolved over time. This study describes discharge diagnoses from the dedicated HIV/AIDS ward at St. Paul's Hospital in Vancouver, Canada. A retrospective database review of admissions to the HIV/AIDS ward between 1 July 2005 and 30 June 2014 was conducted. Primary discharge diagnoses were manually categorized by condition and reviewed by two physicians...
February 4, 2018: AIDS Care
https://www.readbyqxmd.com/read/29380523/dcd-donor-hemodynamics-as-predictor-of-outcome-after-kidney-transplantation
#15
H Peters-Sengers, J H E Houtzager, M B A Heemskerk, M M Idu, R C Minnee, R W Klaasen, S E Joor, J A M Hagenaars, P M Rebers, J J Homan van der Heide, J I Roodnat, F J Bemelman
Insufficient hemodynamics during agonal phase-i.e. the period between withdrawal of life-sustaining treatment and circulatory arrest-in Maastricht category III circulatory-death donors (DCD) potentially exacerbate ischemia/reperfusion injury. We included 409 Dutch adult recipients of DCD donor kidneys transplanted between 2006 and 2014. Peripheral oxygen saturation (SpO2-with pulse oximetry at the fingertip) and systolic blood pressure (SBP-with arterial catheter) were measured during agonal phase, and were dichotomized into minutes of SpO2>60% or SpO2<60%, and minutes of SBP>80 mmHg or SBP<80 mmHg...
January 30, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29361804/global-mortality-burden-of-cirrhosis-and-liver-cancer-attributable-to-injection-drug-use-1990-2016-an-age-period-cohort-and-spatial-autocorrelation-analysis
#16
Jin Yang, Yunquan Zhang, Lisha Luo, Runtang Meng, Chuanhua Yu
We analyzed the temporal and spatial variations in mortality burden of cirrhosis and liver cancer attributable to injection drug use (IDU) from 1990 to 2016. Mortality data of IDU-attributable cirrhosis and IDU-attributable liver cancer on the global and national scales from 1990 to 2016 were collected from the Global Burden of Disease (GBD) studies. Age-period-cohort (APC) model analysis was used to analyze the global mortality trends of target disease, and spatial autocorrelation analysis based on Geographic Information System was applied to illustrate the clusters of the most epidemic countries...
January 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29305727/using-population-based-hospitalization-data-to-monitor-increases-in-conditions-causing-morbidity-among-persons-who-inject-drugs
#17
Melissa G Collier, Mona Doshani, Alice Asher
Epidemics of opioid use and injection drug use (IDU) are associated with an increase in HIV and viral hepatitis infections and overdose deaths in the United States. Persons who inject drugs (PWID) are also at risk for serious infections caused by skin organisms introduced via IDU. We examined National Inpatient Sample hospital discharge data to determine trends in three serious infectious disease-associated conditions that primarily affect PWID in addition to HIV and viral hepatitis: infective endocarditis (IE), central nervous system (CNS) abscesses, and osteomyelitis...
January 5, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29299210/cost-effectiveness-of-methadone-maintenance-treatment-centers-in-prevention-of-human-immunodeficiency-virus-infection
#18
Sirus Pourkhajoei, Mohsen Barouni, Alireza Noroozi, Ahmad Hajebi, Saeed Amini, Mohammad Karamouzian, Hamid Sharifi
Background: Acquired immune deficiency syndrome (AIDS) is one of the greatest social health problems in many communities in the twenty-first century. Methadone maintenance treatment (MMT) could decrease HIV infection among injection drug users (IDU). The main aim of this paper was to determine the cost-effectiveness of the governmental MMT program to prevent human immunodeficiency virus (HIV) infection among IDU. Methods: This analytical study was performed through a before-after assessment during a one-year period...
April 2017: Addiction & Health
https://www.readbyqxmd.com/read/29294581/-incidence-rates-of-hiv-1-epidemics-among-4-high-risk-groups-in-sichuan-province-during-2011-2015
#19
H Yang, L Su, L Ye, L Xiao, Y Hu, M G Shen, D B Wei, D Yuan, G S Zhou, H L Liu, J Yu, S Liang
Objective: Data from the HIV/AIDS surveillance sentinel sites was used to identify the recent HIV-1 infections and to estimate the HIV-1 incidence and epidemic trends among intravenous drug users (IDU), MSM, female sex workers and men attending the sexually transmitted disease clinics in Sichuan province. Methods: Specimens collected from IDUs, MSM, female sex workers and men attending the sexually transmitted disease clinics sentinel sites were confirmed as HIV-1 positive and tested with BED-CEIA. Annual HIV-1 prevalence and incidence rates were calculated and the incidence was adjusted by McNermar method...
December 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29284807/a-clinical-study-of-opioid-substitution-therapy-in-a-tertiary-care-center-of-eastern-india
#20
Satyakam Mohapatra, Mihir Ranjan Nayak, Manaswini Dash
Background: Opioid substitution therapy (OST) is an evidence-based intervention for opiate-dependent persons that replaces illicit drug use with medically prescribed, orally administered opiates such as buprenorphine and methadone. OST reduces HIV risk behaviors and harms associated with injecting opioid. Most of the evidence for OST effectiveness has been generated in middle- and high-income countries where programs are mostly located in dedicated health-care settings; evidence regarding the outcomes of OST programs in low-income countries where OST is often provided in grassroots settings such as drop-in centers is limited...
November 2017: Indian Journal of Psychological Medicine
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