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https://www.readbyqxmd.com/read/28733798/silence-surrounding-hepatitis-c-status-in-risk-relationships-among-rural-people-who-use-drugs
#1
Megan G Hofmeister, Jennifer R Havens, April M Young
Hepatitis C virus (HCV) has reached epidemic proportions in rural Central Appalachia in recent years. We sought to identify demographic, behavioral, and interpersonal characteristics associated with HCV serostatus disclosure among high risk people who use drugs (PWUD) in Appalachian Kentucky. HCV antibody-positive participants (n = 243), drawn from the fifth follow-up assessment of a longitudinal study of rural PWUD, completed interviewer-administered questionnaires eliciting demographic and interpersonal characteristics, risk behaviors, and information about HCV disclosure...
July 21, 2017: Journal of Primary Prevention
https://www.readbyqxmd.com/read/28726043/injection-drug-use-unemployment-and-severe-food-insecurity-among-hiv-hcv-co-infected-individuals-a-mediation-analysis
#2
Taylor McLinden, Erica E M Moodie, Anne-Marie Hamelin, Sam Harper, Sharon L Walmsley, Gilles Paradis, Wusiman Aibibula, Marina B Klein, Joseph Cox
Severe food insecurity (FI), which indicates reduced food intake, is common among HIV-hepatitis C virus (HCV) co-infected individuals. Given the importance of unemployment as a proximal risk factor for FI, this mediation analysis examines a potential mechanism through which injection drug use (IDU) is associated with severe FI. We used biannual data from the Canadian Co-infection Cohort (N = 429 with 3 study visits, 2012-2015). IDU in the past 6 months (exposure) and current unemployment (mediator) were self-reported...
July 19, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28710214/trends-and-factors-in-human-immunodeficiency-virus-and-or-hepatitis-c-virus-testing-and-infection-among-injection-drug-users-newly-entering-methadone-maintenance-treatment-in-guangdong-province-china-2006-2013-a-consecutive-cross-sectional-study
#3
Yin Liu, Yu Liu, Xia Zou, Wen Chen, Li Ling
OBJECTIVES: To assess trends and related factors in HIV and/or hepatitis C virus (HCV) antibody testing and infection among injection drug users (IDUs) newly entering methadone maintenance treatment (MMT) in Guangdong Province, China. METHOD: Consecutive cross sectional surveys were conducted in 14 MMT clinics from July 2006 to December 2013 in Guangdong Province, China. IDUs were excluded if they were re-enrolled or referred from other MMT clinics. Trend tests were used to examine HIV and/or HCV testing and infection, sociodemographic characteristics, drug use related behaviours and the past 3 month sexual behaviours on enrolment...
July 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/28705440/inhibition-of-trkb-at-the-nucleus-accumbens-using-ana-12-regulates-basal-and-stress-induced-orexin-a-expression-within-the-mesolimbic-system-and-affects-anxiety-sociability-and-motivation
#4
Idu Azogu, Helene Plamondon
Repeated stress exposure can lead to the development of anxiety and mood disorders. An emerging biological substrate of depression and associated pathology is the nucleus accumbens (NAc), which through interactions with limbic, cognitive and motor circuits can regulate a variety of stress responses. Within these circuits, orexin neurons are involved in arousal and stress adaptability, effects proposed mediated via brain-derived neurotrophic factor signaling. This study tested the hypotheses that 1) repeated exposure to heterotypic stress alters social ability and preference and passive avoidant behaviors, 2) TrkB receptors at the NAc shell regulates stress-induced behavioral responses and orexin expression within the mesocorticolimbic system...
July 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28700391/human-t-lymphotropic-virus-type-1-infection-and-disease-in-spain
#5
Carmen de Mendoza, Estrella Caballero, Antonio Aguilera, Silvia Requena, Raúl Ortiz de Lejarazu, María Pirón, Rocío González, Ana Jiménez, Lourdes Roc, Ana Treviño, Rafael Benito, Miriam Fernández-Alonso, Aitziber Aguinaga, Carmen Rodríguez, Juan García-Costa, Lidia Blanco, José M Ramos, Enrique Calderón, José M Eirós, Silvia Sauleda, Pablo Barreiro, Vicente Soriano
: Human T-lymphotropic virus type 1 (HTLV-1) infection is a neglected disease despite roughly 15 million people are chronically infected worldwide. Lifelong less than 10% of carriers develop life-threatening diseases, mostly a subacute myelopathy known as tropical spastic paraparesis (TSP) and a lymphoproliferative disorder named adult T-cell leukemia (ATL). HTLV-1 is efficiently transmitted perinatally (breastfeeding), sexually (more from men to women) and parenterally (transfusions, injection drug user (IDU), and transplants)...
July 31, 2017: AIDS
https://www.readbyqxmd.com/read/28693591/aphrodisiac-potentials-of-the-ethanol-extract-of-aloe-barbadensis-mill-root-in-male-wistar-rats
#6
Joseph O Erhabor, MacDonald Idu
BACKGROUND: Aloe barbadensis (AB) is a short stemmed succulent medicinal herb that is being used by locals in Nigeria to enhance libido. Therefore this study evaluates the aphrodisiac potential and acute toxicological effect of A. barbadensis (AB) root in male Wistar rats. METHODS: Aphrodisiac potential was determined following the oral administration of graded doses (100, 200 and 400 mg/kg) of ethanol extract of A. barbadensis root. Sildenafil citrate (Viagra) and distilled water served as positive and negative controls respectively...
July 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28693084/-survey-of-hiv-1-drug-resistance-threshold-in-shandong-province-in-2013-2015
#7
X G Sun, H Y Yu, S L Su, B Lin, J H Li, L Lin, X R Tao, Y S Qian, D M Kang, H Xing
Objective: To survey the prevalence of drug resistant HIV-1 in Shandong province in 2013-2015. Methods: WHO truncated sequential sampling technique was adopted by using 77 and 53 samples of newly diagnosed as HIV-1 positive and aged 16-25 years in Shandong province in 2013 and 2015. RNA was prepared and HIV-1 pol region was amplified by RT-PCR and nested PCR. Pol genetic mutation associated with drug resistance was analyzed. Results: The success rates for sequence acquisition of the survey were 100% (77/77) and 94% (50/53) in 2013 and 2015, and the main subtype was CRF01_AE...
July 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28685884/correlates-of-injection-drug-use-among-rural-appalachian-women
#8
Michele Staton, Gabriele Ciciurkaite, Jennifer Havens, Martha Tillson, Carl Leukefeld, Matthew Webster, Carrie Oser, Bridgette Peteet
BACKGROUND: Limited research has focused on correlates of injection drug use (IDU) among high-risk subgroups of drug users, particularly women, who may be at increased risk for transmission of infectious diseases such as HIV and Hepatitis C. The purpose of this study is to better understand the contextual and health correlates of IDU among women living in rural Appalachia by examining (1) differences between injectors and noninjectors, and (2) the unique correlates of recent IDU and past IDU...
July 7, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28683432/cross-border-injection-drug-use-and-hiv-and-hepatitis-c-virus-seropositivity-among-people-who-inject-drugs-in-san-diego-california
#9
Danielle Horyniak, Karla D Wagner, Richard F Armenta, Jazmine Cuevas-Mota, Erik Hendrickson, Richard S Garfein
BACKGROUND: The prevalence of HIV and Hepatitis C Virus (HCV) are significantly lower among people who inject drugs (PWID) in San Diego, CA, USA compared with PWID in Tijuana, Mexico, located directly across the border. We investigated associations between cross-border injection drug use (IDU), HIV and HCV seroprevalence and engagement in injecting risk behaviours while on each side of the border. METHODS: Using baseline interviews and serologic testing data from STAHR II, a longitudinal cohort study of PWID in San Diego, bivariate and multivariable logistic regression analyses examined associations between recent (past six months) cross-border IDU and HIV and HCV antibody seropositivity, socio-demographics, drug use characteristics, and participants' connections to, and perceptions about Mexico...
July 3, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28678421/cytof-mass-cytometry-for-click-proliferation-assays
#10
Vinko Tosevski, Egor Ulashchik, Andrea Trovato, Paolo Cappella
Novel cell analyzers, including polychromatic flow cytometers and isotopical cytometry by time of flight (CyTOF) mass cytometers, enable simultaneous measurement of virtually bondless characteristics at the single-cell level. BrdU assays for quantifying cellular proliferation are common but have several limitations, including the need for a DNA denaturation step and inability to simultaneously resolve multiple parameters and phenotypic complexity. Click chemistry reactions have become popular in the past decade, as they can resolve these issues...
July 5, 2017: Current Protocols in Cytometry
https://www.readbyqxmd.com/read/28666205/re-examining-blood-donor-deferral-criteria-relating-to-injecting-drug-use
#11
Brendan Quinn, Clive Seed, Anthony Keller, Lisa Maher, David Wilson, Michael Farrell, Sharon Caris, Jennifer Williams, Annie Madden, Alexander Thompson, Joanne Pink, Margaret E Hellard
BACKGROUND AND AIMS: Potential Australian blood donors are deferred indefinitely if they report a history of injecting drug use (IDU), or for 12 months if they report having engaged in sexual activity with someone who might have ever injected. Given incremental improvements in blood safety, this study sought to examine whether Australia's IDU-related eligibility criteria reflected current scientific evidence, were consistent with international best practice and, if current IDU-related policies were to be changed, how this should happen...
June 27, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28649306/decreasing-prevalence-of-transmitted-drug-resistance-among-art-naive-hiv-1-infected-patients-in-iceland-1996-2012
#12
Malik Sallam, Gülşen Özkaya Şahin, Hlynur Indriðason, Joakim Esbjörnsson, Arthur Löve, Anders Widell, Magnus Gottfreðsson, Patrik Medstrand
Introduction: Resistance to antiretroviral drugs can complicate the management of HIV-1 infection and impair control of its spread. The aim of the current study was to investigate the prevalence and transmission of HIV-1 drug resistance among 106 antiretroviral therapy (ART)-naïve patients diagnosed in Iceland (1996-2012). Methods: HIV-1 polymerase sequences were analysed using the Calibrated Population Resistance tool. Domestic spread of transmitted drug resistance (TDR) was investigated through maximum likelihood and Bayesian approaches...
2017: Infection Ecology & Epidemiology
https://www.readbyqxmd.com/read/28636868/deadly-liver-mob-opening-the-door-improving-sexual-health-pathways-for-aboriginal-people-in-western-sydney
#13
Karen Biggs, Jennifer Walsh, Catriona Ooi
BACKGROUND: The Deadly Liver Mob project (DLM) is an incentive-based, peer-driven health promotion intervention for Aboriginal people, focusing on hepatitis C and offering education and screening for sexually transmissible infections (STI) and blood-borne viruses (BBV). This study aims to assess the DLM effect on attendance and STI/BBV screening, describe BBV risk factors and report infection rates among Aboriginal people attending Western Sydney Sexual Health Centre (WSSHC). METHODS: A retrospective review of Aboriginal clients during the first year of the DLM project was compared with Aboriginal clients who attended during the 5...
October 2016: Sexual Health
https://www.readbyqxmd.com/read/28632952/injecting-drug-use-in-low-and-middle-income-countries-opportunities-to-improve-care-and-prevent-harm
#14
Daniel O'Keefe, Mark Stoové, Joseph Doyle, Paul Dietze, Margaret Hellard
Inadequate response to injecting drug use (IDU) is a significant problem the world over. Low levels of funding, political inaction, poor levels of health service coverage, high prevalence and incidence of IDU-related blood-borne viruses (BBVs), and ongoing stigmatisation/marginalisation affect people who inject drugs (PWID) regardless of the income status of the country they reside in. These barriers and system failings are, however, exacerbated in low and middle income countries (LMICs), meaning that the potential consequences of inaction are more pressing...
June 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28622403/using-network-sampling-and-recruitment-data-to-understand-social-structures-related-to-community-health-in-a-population-of-people-who-inject-drugs-in-rural-puerto-rico
#15
Mayra Coronado-García, Courtney R Thrash, Melissa Welch-Lazoritz, Robin Gauthier, Juan Carlos Reyes, Bilal Khan, Kirk Dombrowski
OBJECTIVE: This research examined the social network and recruitment patterns of a sample of people who inject drugs (PWIDs) in rural Puerto Rico, in an attempt to uncover systematic clustering and between-group social boundaries that potentially influence disease spread. METHODS: Respondent driven sampling was utilized to obtain a sample of PWID in rural Puerto Rico. Through eight initial "seeds", 317 injection drug users were recruited. Using recruitment patterns of this sample, estimates of homophily and affiliation were calculated using RDSAT...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28617157/vesicoureteral-reflux-in-kidney-transplantation
#16
Nina M Molenaar, Robert C Minnee, Frederike J Bemelman, Mirza M Idu
BACKGROUND: Vesicoureteral reflux (VUR) is frequently found after transplantation, but its impact on graft function, urine tract infection, and graft loss remains uncertain. Therefore our objective was to evaluate the effects of VUR on the outcome of renal transplantation. MATERIAL AND METHODS: We included 1008 adult renal transplant recipients of whom a 1-week posttransplant voiding cystourethrogram was available. Study end points included occurrence of bacteriuria, renal function, and graft survival...
June 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/28592371/low-yield-of-blood-and-wound-cultures-in-patients-with-skin-and-soft-tissue-infections
#17
Jesus Torres, Nathaniel Avalos, Lamarr Echols, Jillian Mongelluzzo, Robert M Rodriguez
BACKGROUND: Current guidelines recommend blood cultures in skin and soft-tissue infection (SSTI) patients only with signs of systemic toxicity and wound cultures for severe purulent infections. Our objectives were to determine: 1) blood and wound culture yields in patients admitted with SSTIs; 2) whether injection drug users (IDUs) and febrile patients had higher blood culture yields; and 3) whether blood and wound cultures grew organisms sensitive to typical SSTI empiric antibiotics...
May 26, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28578610/a-pilot-study-of-tobacco-screening-and-referral-for-smoking-cessation-program-among-hiv-infected-patients-in-france
#18
Jean-Jacques Parienti, Zine Merzougui, Arnaud de la Blanchardière, Sylvie Dargère, Philippe Feret, Béatrice Le Maitre, Renaud Verdon
BACKGROUND: The prevalence of tobacco smoking is high among patients living with HIV, supporting the need for effective targeted interventions. MATERIALS AND METHODS: All current smokers at our outpatient HIV clinic were invited to participate in a smoking cessation program. RESULTS: Of the 716 patients living with HIV, 280 (39%) reported active smoking and were younger, more recently HIV infected and more frequently infected due to intravenous drug use (IDU)...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28573509/temporal-changes-in-the-modes-of-hepatitis-c-virus-transmission-in-the-usa-and-northern-china
#19
Elizabeth Wu, Ming Yang, Huiying Rao, Sherry Fu, Bo Feng, Ran Fei, Andy Lin, Robert J Fontana, Lai Wei, Anna S Lok
BACKGROUND: Predominant modes of hepatitis C virus (HCV) transmission vary between countries and over time. AIMS: To compare HCV transmission modes in the USA and northern China. METHODS: We conducted a prospective study enrolling two cohorts of chronic HCV patients in the USA, and in China at Beijing, and at Gu'an and Kuancheng counties in Hebei. Patients self-reported the most likely source and year of infection. RESULTS: A total of 1957 patients were studied (1000 USA; 957 China-428 Beijing, 387 Gu'an, 142 Kuancheng)...
August 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28541440/estimating-the-number-of-people-who-inject-drugs-a-proposal-to-provide-figures-nationwide-and-its-application-to-france
#20
Eric Janssen
Background: This article provides an original method of estimating the prevalence of injecting drug users (IDU) in France. Method: In order to overcome legal restrictions hampering data linkage, the method relies on a single-source capture-recapture framework and makes use of individual data collected by a standardized survey conducted within treatment centres. Taking the hierarchical structure of data collection into consideration, a multilevel Zelterman regression model was used...
May 25, 2017: Journal of Public Health
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