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https://www.readbyqxmd.com/read/28648353/healthcare-contact-and-treatment-uptake-following-hepatitis-c-virus-screening-and-counseling-among-rural-appalachian-people-who-use-drugs
#1
Dustin B Stephens, April M Young, Jennifer R Havens
BACKGROUND: Hepatitis C virus (HCV) remains a major contributor to morbidity and mortality worldwide. Since 2009, Kentucky has led the United States in cases of acute HCV, driven largely by injection drug use in rural areas. Improved treatment regimens hold promise of mitigating the impact and transmission of HCV, but numerous barriers obstruct people who inject drugs (PWID) from receiving care, particularly in medically underserved settings. METHODS: 503 rural people who use drugs were recruited using respondent-driven sampling and received HCV screening and post-test counseling...
June 22, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28637724/cross-sectional-association-between-zip-code-level-gentrification-and-homelessness-among-a-large-community-based-sample-of-people-who-inject-drugs-in-19-us-cities
#2
Sabriya L Linton, Hannah Lf Cooper, Mary E Kelley, Conny C Karnes, Zev Ross, Mary E Wolfe, Samuel R Friedman, Don Des Jarlais, Salaam Semaan, Barbara Tempalski, Catlainn Sionean, Elizabeth DiNenno, Cyprian Wejnert, Gabriela Paz-Bailey
BACKGROUND: Housing instability has been associated with poor health outcomes among people who inject drugs (PWID). This study investigates the associations of local-level housing and economic conditions with homelessness among a large sample of PWID, which is an underexplored topic to date. METHODS: PWID in this cross-sectional study were recruited from 19 large cities in the USA as part of National HIV Behavioral Surveillance. PWID provided self-reported information on demographics, behaviours and life events...
June 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28636638/outcomes-from-a-large-10-year-hepatitis-c-treatment-programme-in-people-who-inject-drugs-no-effect-of-recent-or-former-injecting-drug-use-on-treatment-adherence-or-therapeutic-response
#3
Omar Elsherif, Ciaran Bannan, Shay Keating, Susan McKiernan, Colm Bergin, Suzanne Norris
BACKGROUND AND AIMS: People who inject drugs (PWID) are historically viewed as having "difficult to treat" hepatitis C disease, with perceived inferior treatment adherence and outcomes, and concerns regarding reinfection risk. We evaluated for differences in treatment adherence and response to Peginterferon-alfa-2a/Ribavirin (Peg-IFNα/RBV) in a large urban cohort with and without a history of remote or recent injection drug use. METHODS: Patient data was retrospectively reviewed for 1000 consecutive patients-608 former (no injecting drug use for 6 months of therapy), 85 recent (injecting drug use within 6 months) PWID, and 307 non-drug users who were treated for chronic hepatitis C with Peg-IFNα/RBV...
2017: PloS One
https://www.readbyqxmd.com/read/28633998/changes-in-risk-behaviours-during-and-following-treatment-for-hepatitis-c-virus-infection-among-people-who-inject-drugs-the-activate-study
#4
Håvard Midgard, Behzad Hajarizadeh, Evan B Cunningham, Brian Conway, Markus Backmund, Philip Bruggmann, Julie Bruneau, Stefan Bourgeois, Adrian Dunlop, Graham R Foster, Margaret Hellard, Geert Robaeys, Maria C Thurnheer, Martin Weltman, Janaki Amin, Philippa S Marks, Sophie Quiene, Gregory J Dore, Olav Dalgard, Jason Grebely
BACKGROUND: The risk of hepatitis C virus (HCV) reinfection due to continued injecting risk behaviours might remain a barrier to HCV treatment among people who inject drugs. We aimed to evaluate changes in risk behaviours during and following HCV treatment among people with ongoing injecting drug use or receiving opioid substitution treatment (OST). METHODS: ACTIVATE was an international multicentre clinical trial conducted between 2012 and 2014. Participants with HCV genotypes 2/3 infection were treated with peg-interferon/ribavirin for 12 or 24 weeks and completed a self-administered behavioural questionnaire at each study visit...
June 17, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28632952/injecting-drug-use-in-low-and-middle-income-countries-opportunities-to-improve-care-and-prevent-harm
#5
Daniel O'Keefe, Mark Stoové, Joseph Doyle, Paul Dietze, Margaret Hellard
Inadequate response to injecting drug use (IDU) is a significant problem the world over. Low levels of funding, political inaction, poor levels of health service coverage, high prevalence and incidence of IDU-related blood-borne viruses (BBVs), and ongoing stigmatisation/marginalisation affect people who inject drugs (PWID) regardless of the income status of the country they reside in. These barriers and system failings are, however, exacerbated in low and middle income countries (LMICs), meaning that the potential consequences of inaction are more pressing...
June 20, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28629463/how-understanding-and-application-of-drug-related-legal-instruments-affects-harm-reduction-interventions-in-cambodia-a-qualitative-study
#6
Sovannary Tuot, Chanrith Ngin, Khuondyla Pal, Sochenda Sou, Ghazal Sawez, Phylicia Morgan, Mony Srey, Tola Chan, Pheak Chhoun, Olga Golichenko, Sok Chamreun Choub, Siyan Yi
BACKGROUND: Harm reduction interventions in Cambodia face numerous obstacles because of conflicting understanding and interests and inconsistencies in the implementation by law enforcement officials. This study aims to examine how understanding and application of Drug Control Law (DCL) and Village/Commune Safety Policy (VCSP) affects harm reduction interventions in Cambodia from the standpoints of law enforcement officials, people who inject drugs and people who use drugs (PWID/PWUD), as well as other key stakeholders...
June 19, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28628897/diverted-medications-and-new-psychoactive-substances-a-chemical-network-analysis-of-discarded-injecting-paraphernalia-in-hungary
#7
Valéria Anna Gyarmathy, Anna Péterfi, Tamás Figeczki, József Kiss, Katalin Medgyesi-Frank, János Posta, József Csorba
BACKGROUND: Until about 2010, people who inject drugs (PWIDs) injected almost exclusively heroin and amphetamines in Hungary. After 2010, self-reported studies have indicated a dominance of new psychoactive substances on the drug market for injectable drugs. METHODS: Between March 2015 and February 2016, we collected used and discarded injecting paraphernalia. We utilized chemical analysis to assess and UCINet to visualize the connections between the most prevalent main substances and their respective co-occurring additional components at 7 locations in Hungary...
June 16, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28628854/prevalence-and-predictors-of-hcv-among-a-cohort-of-opioid-treatment-patients-in-dar-es-salaam-tanzania
#8
Barrot H Lambdin, Jennifer Lorvick, Jessie K Mbwambo, John Rwegasha, Saria Hassan, Paula Lum, Alex H Kral
BACKGROUND: The government of Tanzania launched an opioid treatment program (OTP), using methadone, in Dar es Salaam in February of 2011. Hepatitis C virus (HCV) is a leading cause of morbidity and mortality globally, especially among people who inject drugs (PWID). We conducted a cross-sectional study among PWID engaged in OTP in Dar es Salaam to describe the prevalence and predictors of HCV antibody serostatus. METHODS: Routine programmatic data on patients enrolled in Muhimbili National Hospital's OTP clinic from February 2011 to January 2013 were utilized...
June 16, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28628853/willingness-to-pay-for-opioid-agonist-treatment-among-opioid-dependent-people-who-inject-drugs-in-ukraine
#9
Iuliia Makarenko, Alyona Mazhnaya, Ruthanne Marcus, Martha J Bojko, Lynn Madden, Sergii Filippovich, Sergii Dvoriak, Frederick L Altice
BACKGROUND: In the context of decreasing external and limited Ukrainian governmental funding for opioid agonist treatments (OAT) for opioid dependent people who inject drugs in Ukraine, information on sustainable financial models is needed. METHODS: Data on 855 opioid dependent people who inject drugs (PWID) were drawn from a cross-sectional nationwide survey of 1613 PWID. They comprised 434 participants who were receiving OAT and 421 who were on OAT in the past or have never been on OAT and were interested in receiving the treatment...
June 16, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28622403/using-network-sampling-and-recruitment-data-to-understand-social-structures-related-to-community-health-in-a-population-of-people-who-inject-drugs-in-rural-puerto-rico
#10
Mayra Coronado-García, Courtney R Thrash, Melissa Welch-Lazoritz, Robin Gauthier, Juan Carlos Reyes, Bilal Khan, Kirk Dombrowski
OBJECTIVE: This research examined the social network and recruitment patterns of a sample of people who inject drugs (PWIDs) in rural Puerto Rico, in an attempt to uncover systematic clustering and between-group social boundaries that potentially influence disease spread. METHODS: Respondent driven sampling was utilized to obtain a sample of PWID in rural Puerto Rico. Through eight initial "seeds", 317 injection drug users were recruited. Using recruitment patterns of this sample, estimates of homophily and affiliation were calculated using RDSAT...
June 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28618981/perceived-effectiveness-of-antiretroviral-therapy-self-rated-health-and-treatment-adherence-among-hiv-positive-people-who-inject-drugs-in-estonia
#11
Pui Y Chan, Michael A Joseph, Don C Des Jarlais, Anneli Uusküla
The HIV epidemic in Estonia affects the population of people who inject drugs (PWID) the most, but factors associated with adherence to antiretroviral therapy (ART) among PWID have not been thoroughly examined in Estonia, with particularly limited data regarding beliefs and attitudes of PWID. The objective of this study was to explore the association between ART adherence and individual beliefs, perceived effectiveness of ART, and self-rated health in particular, in this specific population. The study used baseline survey data from a longitudinal intervention study of HIV prevention among PWID in Estonia, in which 107 HIV-infected participants reported current use of ART...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28618285/belgian-experience-with-direct-acting-antivirals-in-people-who-inject-drugs
#12
Rob Bielen, Christophe Moreno, Hans Van Vlierberghe, Stefan Bourgeois, Jean-Pierre Mulkay, Thomas Vanwolleghem, Wim Verlinden, Christian Brixko, Jochen Decaestecker, Chantal De Galocsy, Filip Janssens, Mike Cool, Lode Van Overbeke, Christophe Van Steenkiste, François D'heygere, Wilfried Cools, Frederik Nevens, Geert Robaeys
BACKGROUND AND AIM: Hepatitis C viral infection (HCV) has become a curable disease due to the development of direct acting antivirals (DAA). The WHO has set a target to eliminate HCV completely. Therefore, people who inject drugs (PWID) also need to be treated. In this study, we compared the real-life uptake and outcome of DAA treatment for HCV in PWID and non-PWID. METHODS: We performed a nation-wide, retrospective cohort study in 15 hospitals. All patients who were treated with simeprevir-sofosbuvir, daclatasvir-sofosbuvir, or ombitasvir/paritaprevir ritonavir-dasabuvir between December 2013 and November 2015 were included...
May 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28616444/incidence-of-hepatitis-c-virus-infection-in-the-human-immunodeficiency-virus-outpatient-study-cohort-2000-2013
#13
Taraz Samandari, Ellen Tedaldi, Carl Armon, Rachel Hart, Joan S Chmiel, John T Brooks, Kate Buchacz
BACKGROUND: There are few recent studies of incident hepatitis C virus (HCV) infection among human immunodeficiency virus (HIV)-infected patients in the United States. METHODS: We studied HIV Outpatient Study (HOPS) participants seen in 9 HIV-specialty clinics who had ≥1 clinical encounter during 2000-2013 and ≥2 HCV-related tests, the first of which was a negative HCV antibody test (Ab). Hepatitis C virus incident cases were identified by first positive HCV Ab, viral load, or genotype...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28615077/service-utilization-and-cost-of-implementing-a-comprehensive-hiv-prevention-and-care-program-among-people-who-inject-drugs-in-delhi-india
#14
Mary Philip Sebastian, Aparajita Dasgupta, Lopamudra Ray Saraswati, Asha Singh, Vartika Sharma, Ira Madan, Waimar Tun, Julie Pulerwitz, Ibou Thior, Avina Sarna
BACKGROUND: WHO, UNODC, and UNAIDS recommend a comprehensive package for prevention, treatment, and care of HIV among people who inject drugs (PWID). We describe the uptake of services and the cost of implementing a comprehensive package for HIV prevention, treatment, and care services in Delhi, India. METHODS: A cohort of 3774 PWID were enrolled for a prospective HIV incidence study and provided the comprehensive package: HIV and hepatitis testing and counseling, hepatitis B (HB) vaccination, syndromic management of sexually transmitted infections, clean needles-syringes, condoms, abscess care, and education...
June 14, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28612212/risk-behaviors-for-hiv-and-hcv-infection-among-people-who-inject-drugs-in-hai-phong-viet-nam-2014
#15
Huong Thi Duong, Don Des Jarlais, Oanh Hai Thi Khuat, Kamyar Arasteh, Jonathan Feelemyer, Pham Minh Khue, Hoang Thi Giang, Didier Laureillard, Vinh Vu Hai, Roselyne Vallo, Laurent Michel, Jean Pierre Moles, Nicolas Nagot
We examined the potential for HIV and hepatitis C (HCV) transmission across persons who inject drugs (PWID), men-who-have-sex-with-men (MSM) and female commercial sex workers (CSW) PWID and the potential for sexual transmission of HIV from PWID to the general population in Hai Phong, Viet Nam. Using respondent driven and convenience sampling we recruited 603 participants in 2014. All participants used heroin; 24% used non-injected methamphetamine. HIV prevalence was 25%; HCV prevalence was 67%. HIV infection was associated with HCV prevalence and both infections were associated with length of injecting career...
June 13, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28606391/tensions-in-relation-how-peer-support-is-experienced-and-received-in-a-hepatitis-c-treatment-intervention
#16
Oliver Bonnington, Magdalena Harris
BACKGROUND: Peer support and involvement is recognised as a vital component of hepatitis C (HCV) treatment provision for marginalised populations, such as people who inject drugs (PWID). Developments in HCV treatments enable increased provision in community settings - expanding the possibilities for meaningful peer involvement in HCV treatment plans. To date, HCV peer support has generally been viewed as a positive intervention, with little critical reflection on the ways social structures, policies, health and drug services and social identity impact on how peer support is experienced and received...
June 9, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28605301/cold-preparation-of-heroin-in-a-black-tar-market
#17
Alexis M Roth, Richard F Armenta, Karla D Wagner, Steffanie A Strathdee, Jesse L Goldshear, Jazmine Cuevas-Mota, Richard S Garfein
BACKGROUND: Black tar heroin is typically prepared for injection with heat which decreases the risk of HIV transmission by inactivating the virus. We received reports that persons who inject drugs (PWID) in Tijuana, Baja California, Mexico, a black tar heroin market, were using only water to dissolve heroin. OBJECTIVES: Because Tijuana abuts San Diego County, CA, United States, we undertook the present analyses to determine the prevalence of this practice among PWID in San Diego, California...
June 12, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28604445/development-of-an-hiv-testing-dashboard-to-complement-the-hiv-care-continuum-among-msm-pwid-and-heterosexuals-in-washington-dc-2007-2015
#18
Rudy Patrick, Alan Greenberg, Manya Magnus, Jenevieve Opoku, Michael Kharfen, Irene Kuo
BACKGROUND: We developed an HIV testing dashboard to complement the HIV care continuum in selected high-risk populations. Using National HIV Behavioral Surveillance (NHBS) data, we examined trends in HIV testing and care for men who have sex with men (MSM), persons who inject drugs (PWID), and heterosexuals at elevated risk (HET). METHODS: Between 2007 and 2015, 4792 participants ≥18 years old completed a behavioral survey and were offered HIV testing. For the testing dashboard, proportions ever tested, tested in the past year, testing HIV-positive, and newly testing positive were calculated...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604444/antiretroviral-therapy-use-among-hiv-infected-people-who-inject-drugs-20-cities-united-states-2009-2015
#19
Brooke E Hoots, Teresa J Finlayson, Dita Broz, Gabriela Paz-Bailey
BACKGROUND: Approximately 16% of infections among those living with diagnosed HIV infection in the United States are attributable to injection drug use. Antiretrovirals (ARVs) are recommended for all infected persons to improve health and prevent transmission. Using data from National HIV Behavioral Surveillance, we evaluated changes in ARV use from 2009 to 2015 among HIV-positive people who inject drugs (PWID). METHODS: PWID were recruited by respondent-driven sampling in 20 cities...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28604437/a-decline-in-hiv-testing-among-persons-who-inject-drugs-in-the-seattle-area-2004-2015
#20
Richard D Burt, Joe Tinsley, Sara Nelson Glick
BACKGROUND: Promoting HIV testing is a key component of the public health response to HIV. Assessing HIV testing frequency among persons who inject drugs (PWID) monitors the status of these efforts and can identify unmet needs and opportunities to more effectively promote testing. METHODS: Data were combined from 4 Seattle-area surveys of PWID from the National HIV Behavioral Surveillance (NHBS) program (2005-2015) and 6 surveys of Needle Exchange clients (2004-2015)...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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