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Julia M Fraile, Diana Campos-Iglesias, Francisco Rodríguez, Yaiza Español, José M P Freije
Ubiquitin-Specific Proteases (USPs) are deubiquitinating enzymes frequently deregulated in human malignancies. Here, we show that USP54 is overexpressed in intestinal stem cells and demonstrate that its downregulation in colorectal carcinoma cells impedes tumorigenesis. We have generated mutant mice deficient for this deubiquitinase, which are viable and fertile, and protected against chemically-induced colorectal carcinoma. Furthermore, we show that USP54 is upregulated in human colon cancer and associates with poor prognosis...
October 19, 2016: Oncotarget
Rosana Espuig Sebastián, Ana Lucía Noreña Peña, Ernesto Cortés Castel, Juan de Diego González-San
Introducción: el estado nutricional previo de la embarazada, la adecuada ganancia de peso y la ingesta de ciertos nutrientes pueden tener una influencia importante tanto para la madre como para el recién nacido, a corto y largo plazo. Las recomendaciones de la Organización Mundial de la Salud son transmitidas durante el control del embarazo por la matrona.Objetivos: analizar los principales estudios sobre la percepción de las embarazadas acerca de los consejos nutricionales recibidos e identificar las estrategias utilizadas por las matronas para su implementación...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jürgen Rehm, Gerrit Gmel, Cristina Serra, Antoni Gual
AbstractWith help of a simulation study, the potential effects of better detection of hypertension and improved screening for alcohol problems with subsequent interventions were estimated.  Results showed, that if 50% of Spanish men between 40 and 64 years of age currently not aware of their hypertension could be made aware of their condition and received usual interventions, and 50% among men with hypertension would be screened for alcohol and received interventions for hazardous drinking or treatment for alcohol use disorders, the percentage of uncontrolled hypertension among men with hypertension would decrease from 61...
September 29, 2016: Adicciones
Airama Albisa, Laura Español, Martin Prieto, Victor Sebastian
BACKGROUND: Bio-nanomaterials assembled into nanomembrane entities are actively studied to circumvent the uncontrollable list of shortcomings of conventional delivery systems: low water solubility, unfavorable stability, short circulation time in plasma, rapid clearance from the human body, poor bioavailability, non-specific toxicity against normal tissue and cells, low cellular uptake and susceptibility to enzyme degradation. Basically, these nanoentities enable to exploit the therapeutic value of many promising biomolecules and drugs (B&D), controlling the mass transport of B&D at a certain rate or even on demand if a stimulus is applied...
October 10, 2016: Current Pharmaceutical Design
Marta Martin-Richard, Angels Ginès, Juan Ramón Ayuso, Luis Sabater, Joan Fabregat, Ramiro Mendez, Glòria Fernández-Esparrach, Xavier Molero, Eva C Vaquero, Miriam Cuatrecasas, Antonio Ferrández, Joan Maurel
BACKGROUND AND OBJECTIVE: Clinical management of adenocarcinoma of the pancreas is complex, and requires a multidisciplinary approach. The same applies for the premalignant lesions that are increasingly being diagnosed. The current document is an update on the diagnosis and management of premalignant lesions and adenocarcinoma of the pancreas. PATIENTS AND METHODS: A conference to establish the basis of the literature review and manuscript redaction was organized by the Grupo Español Multidisciplinar en Cáncer Digestivo...
October 7, 2016: Medicina Clínica
R Delgado-Buscalioni
A relatively general thermodynamic formalism for adaptive molecular resolution (AMR) is presented. The description is based on the approximation of local thermodynamic equilibrium and considers the alchemic parameter λ as the conjugate variable of the potential energy difference between the atomistic and coarse-grained model Φ=U((1))-U((0)) The thermodynamic formalism recovers the relations obtained from statistical mechanics of H-AdResS (Español et al, J. Chem. Phys. 142, 064115, 2015 (doi:10.1063/1.4907006)) and provides relations between the free energy compensation and thermodynamic potentials...
November 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
M Teresa de la Morena, David Leonard, Troy R Torgerson, Otavio Cabral-Marques, Mary Slatter, Asghar Aghamohammadi, Sharat Chandra, Luis Murguia-Favela, Francisco Bonilla, Maria Kanariou, Rongras Damrongwatanasuk, Caroline Y Kuo, Christopher C Dvorak, Isabelle Meyts, Karin Chen, Lisa Kobrynski, Neena Kapoor, Darko Richter, Daniela DiGiovanni, Fatima Dhalla, Evangelia Farmaki, Carsten Speckmann, Teresa Espanol, Anna Shcherbina, Celine Hanson, Jiri Litzman, John Routes, Melanie Wong, Ramsay Fuleihan, Suranjith L Seneviratne, Trudy N Small, Ales Janda, Liliana Bezrodnik, Reinhard Seger, Andrea Gomez Raccio, J David M Edgar, Janet Chou, Jordan K Abbott, Joris van Montfrans, Luis Ignacio Gonzalez-Granado, Nancy Bunin, Necil Kutukculer, Paul Gray, Gisela Seminario, Srdjan Pasic, Victor Aquino, Christian Wysocki, Hassan Abolhassani, Eyal Grunebaum, Morna Dorsey, Beatriz Tavares Costa Carvalho, Antonio Condino-Neto, Charlotte Cunningham-Rundles, Alan P Knutsen, John Sleasman, Helen Chapel, Hans D Ochs, Alexandra Filipovich, Mort Cowan, Andrew Gennery, Andrew Cant, Luigi D Notarangelo, Chaim Roifman
BACKGROUND: X-linked hyper IgM syndrome (XHIGM) is a primary immunodeficiency with high morbidity and mortality compared to normal individuals. Hematopoietic cell transplant (HCT) has been considered a curative therapy, but the procedure has inherent complications, and may not be available for all patients. OBJECTIVES: We sought to collect data on the clinical presentation, treatment, and follow-up of a large sample of patients with XHIGM in order to (1) compare long-term overall survival and general well-being of patients treated with or without HCT along with clinical factors associated with mortality, and (2) summarize clinical practice and risk factors in the subgroup of patients treated with HCT...
September 30, 2016: Journal of Allergy and Clinical Immunology
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Intellectual and Developmental Disabilities
(no author information available yet)
No abstract text is available yet for this article.
September 2016: American Journal on Intellectual and Developmental Disabilities
(no author information available yet)
A clinical case is presented that was communicated to Spanish Notification System on Safety in Anaesthesia and Recovery (SENSAR). Using this communication and its analysis, a strategy is obtained in order to reduce the risks associated with the insertion of a nasogastric tube (NST) for enteral nutrition in adult patients in the post-surgical recovery unit. A description of the incident is presented, an analysis of its causes, and the measures that were introduced in order to avoid similar incidents in the future, as well as to promote a safety culture in the organisation...
September 5, 2016: Revista Española de Anestesiología y Reanimación
Ramón García-Sanz, Luis Antonio Corchete, Miguel Alcoceba, María Carmen Chillon, Cristina Jiménez, Isabel Prieto, María García-Álvarez, Noemi Puig, Immaculada Rapado, Santiago Barrio, Albert Oriol, María Jesús Blanchard, Javier de la Rubia, Rafael Martínez, Juan José Lahuerta, Marcos González Díaz, María Victoria Mateos, Jesús Fernando San Miguel, Joaquín Martínez-López, María Eugenia Sarasquete
Bortezomib- and thalidomide-based therapies have significantly contributed to improved survival of multiple myeloma (MM) patients. However, treatment-induced peripheral neuropathy (TiPN) is a common adverse event associated with them. Risk factors for TiPN in MM patients include advanced age, prior neuropathy, and other drugs, but there are conflicting results about the role of genetics in predicting the risk of TiPN. Thus, we carried out a genome-wide association study based on more than 300 000 exome single nucleotide polymorphisms in 172 MM patients receiving therapy involving bortezomib and thalidomide...
September 8, 2016: Hematological Oncology
Fábio da Costa Carbogim, Larissa Bertacchini de Oliveira, Vilanice Alves de Araújo Püschel
OBJECTIVE: to analyze the concept of critical thinking (CT) in Rodger's evolutionary perspective. METHOD: documentary research undertaken in the Cinahl, Lilacs, Bdenf and Dedalus databases, using the keywords of 'critical thinking' and 'Nursing', without limitation based on year of publication. The data were analyzed in accordance with the stages of Rodger's conceptual model. The following were included: books and articles in full, published in Portuguese, English or Spanish, which addressed CT in the teaching and practice of Nursing; articles which did not address aspects related to the concept of CT were excluded...
2016: Revista Latino-americana de Enfermagem
Ismael San Mauro Martin, Paula Mendive Dubourdieu, Víctor Paredes Barato, Elena Garicano Vilar
Introducción: la tradición de la comida picante desempeña un papel muy importante en el gusto por este tipo de comida y su tolerancia. Las preferencias alimentarias muestran influencia genética y ambiental.Objetivos: estudiar la tolerancia y el gusto por el picante de tres poblaciones, y la influencia hereditaria y del ambiente.Métodos:se realizó una encuesta a 522 sujetos, de tres continentes (Asia, Europa y Latinoamérica) en tres idiomas (español, inglés y chino) a través de Internet. Se realizaron preguntas acerca de la tolerancia al picante, el gusto por los alimentos picantes, su uso, la edad de comienzo de consumo, el gusto del padre y de la madre y si ella lo consumía durante el embarazo y/o lactancia...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Alberto Grao-Cruces, Nuno Loureiro, Antonio Fernández-Martínez, Jorge Mota
Introducción y objetivos: examinar la asociación del apoyo de los padres y de los amigos con diferentes intensidades de actividad física durante el tiempo libre de adolescentes españoles de ambos sexos.Métodos: un total 352 adolescentes españoles (51.70% chicos; 12-16 años) cumplimentaron el International Physical Activity Questionnarie for Adolescents y un cuestionario validado sobre apoyo social. Se realizaron análisis de regresión linear ajustados por edad.Resultados: el apoyo social de padres y amigos influyó positivamente sobre los niveles de actividad física vigorosa que los adolescentes españoles realizan durante su tiempo libre (β=...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
G Ruiz-Irastorza, M Garcia, G Espinosa, L Caminal, F Mitjavila, R González-León, B Sopeña, J Canora, M V Villalba, M Rodríguez-Carballeira, J M López-Dupla, J L Callejas, A Castro, C Tolosa, M E Sánchez-García, M Pérez-Conesa, N Navarrete-Navarrete, A P Rodríguez, M T Herranz, L Pallarés
AIM: To study the influence of prednisone dose during the first month after systemic lupus erythematosus (SLE) diagnosis (prednisone-1) on glucocorticoid burden during the subsequent 11 months (prednisone-2-12). METHODS: 223 patients from the Registro Español de Lupus Eritematoso Sistémico inception cohort were studied. The cumulative dose of prednisone-1 and prednisone-2-12 were calculated and recoded into a four-level categorical variable: no prednisone, low dose (up to 7...
2016: Lupus Science & Medicine
(no author information available yet)
No abstract text is available yet for this article.
August 2016: Intellectual and Developmental Disabilities
Belén Aracil-García, Jesús Oteo-Iglesias, Óscar Cuevas-Lobato, Noelia Lara-Fuella, Isabel Pérez-Grajera, Sara Fernández-Romero, María Pérez-Vázquez, José Campos
INTRODUCTION: An analysis was made about the evolution of resistance to 3rd generation cephalosporins, imipenem, and other antibiotics in invasive isolates of Klebsiella pneumoniae (K. pneumoniae) according to the Spanish EARS-Net database (2010-2014). METHODS: Forty-two hospitals from 16 Autonomous Communities with an approximate population coverage of 33% participated. RESULTS: A total 7,140 pneumoniae corresponding to the same number of patients were studied...
July 25, 2016: Enfermedades Infecciosas y Microbiología Clínica
Carme Pinyol, Jose M Cepeda, Inmaculada Roldan, Vanesa Roldan, Silvia Jimenez, Paloma Gonzalez, Javier Soto
INTRODUCTION: Economic evaluations are becoming increasingly important due to limitations in economic resources, the expense of many new treatments, the need to allocate health spending as effectively as possible, and the need to inform decision makers. Based on the data from the apixaban studies (ARISTOTLE and AVERROES), several economic evaluations have been performed in various countries to demonstrate the efficacy of apixaban versus warfarin and aspirin or other new oral anticoagulants (NOACs) for preventing stroke in patients with non-valvular atrial fibrillation (NVAF)...
July 25, 2016: Cardiology and Therapy
Tania Carbayo, Alba de la Mata, Marina Sánchez, Jesús López-Herce, Jimena Del Castillo, Angel Carrillo
OBJECTIVE: To assess the frequency of the multiple organ failure and the prognostic value of multiple organ failure scores in children who have recovered from an in-hospital cardiac arrest. PATIENTS AND METHODS: A single centre, observational, and retrospective study was conducted on children between 1 month and 16 years old who suffered an in-hospital cardiac arrest and achieved return of spontaneous circulation (ROSC). In the first 24-48hours and between the fifth and the seventh day after ROSC, a record was made of the scores on paediatric severity (PRISM and PIM II) and multiple organ failure scales (PELOD and P-MODS), along with the clinical and analytical data, and including monitoring and treatment, mortality and cause of death...
July 20, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Adriana Quesada, Gabriel A Reginatto, Ayelen Ruiz Español, Lisandro D Colantonio, María Soledad Burrone
OBJECTIVES: To analyze all information available on antimicrobial-resistant Salmonella species isolated from foods of animal origin that are used for human consumption in Latin America. MATERIALS AND METHODS: A systematic review of observational epidemiological studies conducted in Latin America between 2003 and 2014 was carried out using the PubMed and LILACS databases. Studies conducted as part of analyses of outbreaks or cases of human infection were not included...
March 2016: Revista Peruana de Medicina Experimental y Salud Pública
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