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https://www.readbyqxmd.com/read/29679858/anti-inflammatory-effect-of-apo-9-fucoxanthinone-via-inhibition-of-mapks-and-nf-kb-signaling-pathway-in-lps-stimulated-raw-264-7-macrophages-and-zebrafish-model
#1
Eun-A Kim, Seo-Young Kim, Bo-Ram Ye, Junseong Kim, Seok-Chun Ko, Won Woo Lee, Kil-Nam Kim, Il-Whan Choi, Won-Kyo Jung, Soo-Jin Heo
In this study, we confirmed the anti-inflammatory effect of Apo-9-fucoxanthinone (AF) in in vitro RAW 264.7 cells and in vivo zebrafish model. In lipopolysaccharide (LPS)-stimulated zebrafish, AF significantly decreased the production of reactive oxygen species (ROS), nitric oxide (NO) and cell death. In addition, the mRNA expression of inducible nitric oxide synthase (iNOS), suppressed cyclooxygenase-2 (COX-2) and an inflammatory cytokines; IL-1β, TNF-α were shown reduction. And AF significantly inhibited NO production and expression of iNOS in LPS-stimulated RAW 264...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679752/thermodynamic-compatibility-between-cyclodextrin-supramolecular-complexes-and-surfactant
#2
Larissa H R Meira, Guilherme A B Soares, Homero I M Bonomini, Juliana Fedoce Lopes, Frederico B De Sousa
Supramolecular structures based on cyclodextrins have been extensively used for drug delivery systems over decades. However, combining host and guest molecules in a pharmaceutical formulation is not a trivial process, being one of the majors concern the inclusion complex compatibility with other excipients presented in the final formulation. Herein, experimental and theoretical calculations were used to investigate the competition of sodium dodecyl sulfate (SDS) with atenolol (ATE) or losartan (LOS), antihypertensive drugs widely used in the treatment of hypertension...
April 18, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29678593/characterisation-of-aptamer-bc-007-substance-and-product-using-circular-dichroism-and-nuclear-magnetic-resonance-spectroscopy
#3
Hardy Weisshoff, Katrin Wenzel, Sarah Schulze-Rothe, Heike Nikolenko, Hanna Davideit, Niels-Peter Becker, Peter Göttel, G Susan Srivatsa, Margitta Dathe, Johannes Müller, Annekathrin Haberland
Possible unwanted folding of biopharmaceuticals during manufacturing and storage has resulted in analysis schemes compared to small molecules that includes bioanalytical characterisation besides chemical characterisation. Whether bioanalytical characterisation is required for nucleotide-based drugs, may be decided on a case-by-case basis. Nucleotide-based pharmaceuticals, if chemically synthesised, occupy an intermediate position between small-molecule drugs and biologics. Here, we tested whether a physicochemical characterisation of a nucleotide-based drug substance, BC 007, was adequate, using circular dichroism (CD) spectroscopy...
April 17, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29667600/is-eye-lens-dosimetry-needed-in-nuclear-medicine
#4
Malgorzata Wrzesien, Leszek Krolicki, Lukasz Albiniak, Jerzy Olszewski
INTRODUCTION: The specificity of personnel exposure, which distinguishes nuclear medicine, is associated with the form of the radiation source used, and this often requires performing manual procedures while using radioactive isotopes. The variety of radionuclides and medical procedures, and the yearly increase in the number of patients, as well as the change of the individual dose limit for the lens of the eye from a value of 150 mSv per year to a level of 20 mSv, means that issues of eye lens routine dosimetry become interesting from the radiation protection point of view...
April 18, 2018: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29653457/difficulties-in-differentiating-natural-from-synthetic-alkaloids-by-isotope-ratio-monitoring-using-13c-nuclear-magnetic-resonance-spectrometry
#5
Richard J Robins, Katarzyna M Romek, Mathilde Grand, Pierrick Nun, Didier Diomande, Maxime Julien, Gérald S Remaud
Within the food and pharmaceutical industries, there is an increasing legislative requirement for the accurate labeling of the product's origin. A key feature of this is to indicate whether the product is of natural or synthetic origin. With reference to this context, we have investigated three alkaloids commonly exploited for human use: nicotine, atropine, and caffeine. We have measured by 13 C nuclear magnetic resonance spectrometry the position-specific distribution of 13 C at natural abundance within several samples of each of these target molecules...
April 13, 2018: Planta Medica
https://www.readbyqxmd.com/read/29653414/new-insights-on-the-modulatory-roles-of-metformin-or-alpha-lipoic-acid-versus-their-combination-in-dextran-sulfate-sodium-induced-chronic-colitis-in-rats
#6
Fatma S Samman, Samah M Elaidy, Soha S Essawy, Mohammad S Hassan
BACKGROUND: Dextran sulfate sodium (DSS)-induced colitis is the most widely used model that resembles ulcerative colitis (UC) in human with challenging chronic mechanistic oxidative stress-inflammatory/immunological cascades. In models of acute colitis, reduction of oxidative stress and inflammatory burdens beside manipulation of many transcriptional factors were achieved by metformin or alpha-lipoic acid (α-LA). Currently, in vivo DSS-induced chronic colitis was conducted and the possible therapeutic roles of metformin and/or α-LA were explored...
November 24, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29616400/stable-expression-of-adalimumab-in-nicotiana-tabacum
#7
Tzvi Zvirin, Lena Magrisso, Amit Yaari, Oded Shoseyov
Production of monoclonal antibodies and pharmaceutical proteins in transgenic plants has been the focus of many research efforts for close to 30 years. Use of plants as bioreactors reduces large-scale production costs and minimizes risk for human pathogens contamination. Stable nuclear transformation of the plant genome offers a clear advantage in agricultural protein production platforms, limited only by the number of hectares that can be cultivated. We report here, for the first time, successful and stable expression of adalimumab in transgenic Nicotiana tabacum plants...
April 3, 2018: Molecular Biotechnology
https://www.readbyqxmd.com/read/29601518/high-level-expression-and-purification-of-the-clinically-active-antimicrobial-peptide-p-113-in-escherichia-coli
#8
Kuang-Ting Cheng, Chih-Lung Wu, Bak-Sau Yip, Hui-Yuan Yu, Hsi-Tsung Cheng, Ya-Han Chih, Jya-Wei Cheng
P-113, which was originally derived from the human saliva protein histatin 5, is a histidine-rich antimicrobial peptide with the sequence AKRHHGYKRKFH. P-113 is currently undergoing phase II clinical trial as a pharmaceutical agent to fight against fungal infections in HIV patients with oral candidiasis. Previously, we developed a new procedure for the high-yield expression and purification of hG31P, an analogue and antagonist of human CXCL8. Moreover, we have successfully removed lipopolysaccharide (LPS, endotoxin) associated with hG31P in the expression with Escherichia coli ...
March 30, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29599397/pharmacology-part-1-introduction-to-pharmaoclogy-and-pharmacodynamics
#9
Geoffrey M Currie
There is an emerging need for greater understanding of pharmacology principles amongst technical staff. Indeed, the responsibility of dose preparation and administration, under any level of supervision, demands foundation understanding of pharmacology. This is true for radiopharmaceuticals, contrast media and pharmaceutical interventions / adjunctive medications. Regulation around the same might suggest a need to embed pharmacology theory in undergraduate education programs and there is a need to disseminate that same foundation understanding to practicing clinicians...
March 29, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29589540/-lactoferrin-and-peptide-derivatives-antimicrobial-agents-with-potential-use-in-nonspecific-immunity-modulation
#10
Maria Elisa Drago-Serrano, Rafael Campos-Rodriguez, Julio Cesar Carrero, Mireya de la Garza
Lactoferrin (Lf) is a conserved cationic non-heme glycoprotein that is part of the innate immune defense system of mammals. Lf is present in colostrum, milk and mucosal sites, and it is also produced by polymorphonuclear neutrophils and secreted at infection sites. Lf and Lf N-terminus peptide-derivatives named lactoferricins (Lfcins) are molecules with microbiostatic and microbicidal action in a wide array of pathogens. In addition, they display regulatory properties on components of nonspecific immunity, including toll-like receptors, pro- and anti-inflammatory cytokines, and reactive oxygen species...
March 27, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29582482/metal-organic-frameworks-for-separation
#11
REVIEW
Xiang Zhao, Yanxiang Wang, Dong-Sheng Li, Xianhui Bu, Pingyun Feng
Separation is an important industrial step with critical roles in the chemical, petrochemical, pharmaceutical, and nuclear industries, as well as in many other fields. Although much progress has been made, the development of better separation technologies, especially through the discovery of high-performance separation materials, continues to attract increasing interest due to concerns over factors such as efficiency, health and environmental impacts, and the cost of existing methods. Metal-organic frameworks (MOFs), a rapidly expanding family of crystalline porous materials, have shown great promise to address various separation challenges due to their well-defined pore size and unprecedented tunability in both composition and pore geometry...
March 27, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29575954/ototoxicity-the-radical-drum-beat-and-rhythm-of-cochlear-hair-cell-life-and-death
#12
David V Gauvin, Joshua Yoder, Zachary J Zimmermann, Rachel Tapp
The function and structure of the auditory information processing system establishes a unique sensory environment for the "perfect storm." The battle between life and death pits the cascade of an apoptotic storm, programmed cell death cascades, against simple cell death (necrosis) pathways. Live or die, the free radical biology of oxygen and hydroxylation, and the destruction of transition metal migration through the mechanical gate sensory processes of the hair cell lead to direct access to the cytoplasm, cytoplasmic reticulum, and mitochondria of the inner workings of the hair cells...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29571131/nuclear-magnetic-resonance-spectroscopy-as-a-tool-for-the-quantitative-analysis-of-water-and-ions-in-pharmaceuticals-example-of-heparin
#13
Yulia B Monakhova, Bernd W K Diehl
Heparin is a linear, highly sulfated glycosaminoglycan (GAG), which consists of repeating disaccharide units of β-d-glucuronic acid or α-l-iduronic acid and α-d-glucosamine. While robust analytical approaches exist for the characterization of organic composition of heparin preparations, there is a lack of methods for the simultaneous quantification of inorganic compounds (water, anions, cations) in this matrix. A nuclear magnetic resonance (NMR) spectrometric method for heparin characterization described in US Pharmacopeia was extended to simultaneous analysis of the inorganic ions (sodium, calcium, and chloride), acetate as well as water content...
March 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29565650/recent-advances-in-theranostics-and-challenges-for-the-future
#14
J Harvey Turner
Theranostic nuclear oncology is on the cusp of adoption into routine clinical management of neuroendocrine tumours (NETs) following publication of the Phase 3 randomized controlled trial, NETTER-1. For the first time, level 1b evidence of efficacy and safety of 68-gallium/177 lutetium-DOTA-octreotatepeptide receptor radionuclide therapy (PRRT), of midgut NETs was established. Multicentre Phase 2 studies of 68-gallium/177 lutetium-PSMA theranostic approaches to management of end-stage metastatic castrate-resistant prostate cancer (mCRPC), are also very encouraging...
March 22, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29525567/cargo-free-particles-of-ammonio-methacrylate-copolymers-from-pharmaceutical-inactive-ingredients-to-effective-anticancer-immunotherapeutics
#15
Maryam Alsadat Shetab Boushehri, Valentin Stein, Alf Lamprecht
Nanoparticles create exciting platforms for anticancer immunotherapy and vaccination, though their inherent immunomodulatory properties have remained underexploited. Ammonio methacrylate copolymers (AMC) are well-established excipients in pharmaceutical industry and components of controlled-release oral formulations. Here, we demonstrate that nanoscaling of type A and B AMC (Eudragit® RL and RS) endows these inactive ingredients immunostimulatory properties exploitable for cancer therapy. The particles induce the secretion of various pro-inflammatory cytokines and chemokines from the cells of innate immunity...
March 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29520394/development-and-validation-of-a-high-pressure-liquid-chromatography-method-for-the-determination-of-chemical-purity-and-radiochemical-purity-of-a-68-ga-labeled-glu-urea-lys-ahx-hbed-cc-positron-emission-tomography-tracer
#16
Silvia Migliari, Antonino Sammartano, Maura Scarlattei, Giulio Serreli, Caterina Ghetti, Carla Cidda, Giorgio Baldari, Ornella Ortenzia, Livia Ruffini
Background : Prostate-specific membrane antigen (PSMA) has gained high attention as a useful biomarker in the imaging evaluation of prostate cancer with positron emission tomography (PET) during recent years. [68 Ga]-labeled Glu-urea-Lys(Ahx)-HBED-CC ([68 Ga]-PSMA-HBED-CC) is a novel PSMA inhibitor radiotracer which has demonstrated its suitability in detecting prostate cancer. Preparation conditions may influence the quality and in vivo behavior of this tracer, and no standard procedure for the quality control (QC) is available...
October 31, 2017: ACS Omega
https://www.readbyqxmd.com/read/29518973/new-terpenoids-from-chamaecyparis-formosensis-cupressaceae-leaves-with-modulatory-activity-on-matrix-metalloproteases-2-and-9
#17
Meng-Lun Chang, Hui-Ching Mei, I-Chih Kuo, George Hsiao, Yueh-Hsiung Kuo, Ching-Kuo Lee
Chamaecyparis formosensis is Taiwan's most representative tree, and has high economic value. To date, only a few active chemical constituents have been reported for C. formosensis . In this study, 37 secondary metabolites, including three new compounds ( 1 - 3 ), were extracted from the leaves of C. formosensis . The compounds isolated from the ethyl acetate layer were used at different concentrations to treat HT-1080 human fibrosarcoma cells and to evaluate their effects on matrix metalloprotease 2 (MMP-2) and 9 (MMP-9) expression...
March 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29512903/tracking-down-a-novel-steroid-hydroxylating-promiscuous-cytochrome-p450-cyp154c8-from-streptomyces-sp-w2233-sm
#18
Bikash Dangi, Ki-Hwa Kim, Sang-Ho Kang, Tae-Jin Oh
CYP154C8 from Streptomyces sp. was identified as a novel cytochrome P450 with substrate flexibility to different sets of steroids. The in vitro reaction of these steroids with CYP154C8 revealed interesting product formation patterns with the same group of steroids. Nuclear magnetic resonance study revealed the major product of corticosterone hydroxylated at the C21 position; while progesterone, androstenedione, testosterone, and 11-ketoprogesterone were exclusively hydroxylated at 16α position. However, the 16α-hydroxylated product of progesterone was further hydroxylated to yield dihydroxylated products...
March 7, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29488104/identification-of-ortho-substituted-benzoic-acid-ester-derivatives-via-the-gas-phase-neighboring-group-participation-effect-in-esi-high-resolution-mass-spectrometry
#19
William D Blincoe, Agustina Rodriguez-Granillo, Josep Saurí, Nicholas A Pierson, Leo A Joyce, Ian Mangion, Huaming Sheng
Benzoic acid/ester/amide derivatives are common moieties in pharmaceutical compounds and present a challenge in positional isomer identification by traditional tandem mass spectrometric analysis. A method is presented for exploiting the gas-phase neighboring group participation (NGP) effect to differentiate ortho-substituted benzoic acid/ester derivatives with high resolution mass spectrometry (HRMS1 ). Significant water/alcohol loss (>30% abundance in MS1 spectra) was observed for ortho-substituted nucleophilic groups; these fragment peaks are not observable for the corresponding para and meta-substituted analogs...
February 27, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29486126/fast-magic-angle-spinning-19f-spin-exchange-nmr-for-determining-nanometer-19f-19f-distances-in-proteins-and-pharmaceutical-compounds
#20
Matthias Roos, Tuo Wang, Alexander A Shcherbakov, Mei Hong
Internuclear distances measured using NMR provide crucial constraints of three-dimensional structures, but are often restricted to about 5 Å due to the weakness of nuclear-spin dipolar couplings. For studying macromolecular assemblies in biology and materials science, distance constraints beyond 1 nm will be extremely valuable. Here we present an extensive and quantitative analysis of the feasibility of 19F spin exchange NMR for precise and robust measurements of inter-atomic distances to 1.6 nm at a magnetic field of 14...
February 27, 2018: Journal of Physical Chemistry. B
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