keyword
MENU ▼
Read by QxMD icon Read
search

Nuclear pharmaceutical

keyword
https://www.readbyqxmd.com/read/27922103/hypothalamic-activation-is-essential-for-endotoxemia-induced-acute-muscle-wasting
#1
Kaipeng Duan, Qiyi Chen, Minhua Cheng, Chenyan Zhao, Zhiliang Lin, Shanjun Tan, Fengchan Xi, Tao Gao, Jialiang Shi, Juanhong Shen, Weiqin Li, Wenkui Yu, Jieshou Li, Ning Li
Growing evidence suggests acute skeletal muscle wasting is a key factor affecting nutritional support and prognosis in critical patients. Previously, plenty of studies of muscle wasting focused on the peripheral pathway, little was known about the central role. We tested the hypothesis whether central inflammatory pathway and neuropeptides were involved in the process. In lipopolysaccharide (LPS) treated rats, hypothalamic NF-κB pathway and inflammation were highly activated, which was accompanied with severe muscle wasting...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920947/the-daniel-k-inouye-college-of-pharmacy-scripts-poha-berry-physalis-peruviana-with-potential-anti-inflammatory-and-cancer-prevention-activities
#2
Leng Chee Chang, Mayuramas Sang-Ngern, John M Pezzuto, Carolyn Ma
The Daniel K. Inouye College of Pharmacy, during a historic event in Spring 2016, graduated the first two students in the Pacific region to earn a PhD in pharmaceutical sciences at the University of Hawai'i at Hilo. The college offers PhD programs in these five disciplines: Cancer Biology, Medicinal Chemistry, Pharmaceutics, Pharmacognosy, and Pharmacology. One of the Pharmacognosy dissertations focused on plant-derived natural products with potential anti-inflammatory and cancer chemopreventive activities...
November 2016: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/27916640/ppar-agonists-could-tissue-targeting-pave-the-way
#3
Anne Bugge, Dorte Holst
Over the last couple of decades, the PPAR family of transcription factors has received much attention from the pharmaceutical industry due to their profound ability to improve glucose and lipid metabolism upon agonist activation. However, more recently the interest in these nuclear receptors has faded because several clinical trials have shown that it is difficult to develop a ligand that significantly ameliorates glucose and lipid metabolism disorders without concomitantly inducing unacceptable side-effects...
December 1, 2016: Biochimie
https://www.readbyqxmd.com/read/27900420/nmr-based-metabolomic-approach-to-study-urine-samples-of-chronic-inflammatory-rheumatic-disease-patients
#4
Alessia Vignoli, Donatella Maria Rodio, Anna Bellizzi, Anatoly Petrovich Sobolev, Elena Anzivino, Monica Mischitelli, Leonardo Tenori, Federico Marini, Roberta Priori, Rossana Scrivo, Guido Valesini, Ada Francia, Manuela Morreale, Maria Rosa Ciardi, Marco Iannetta, Cristiana Campanella, Donatella Capitani, Claudio Luchinat, Valeria Pietropaolo, Luisa Mannina
The nuclear magnetic resonance (NMR)-based metabolomic approach was used as analytical methodology to study the urine samples of chronic inflammatory rheumatic disease (CIRD) patients. The urine samples of CIRD patients were compared to the ones of both healthy subjects and patients with multiple sclerosis (MS), another immuno-mediated disease. Urine samples collected from 39 CIRD patients, 25 healthy subjects, and 26 MS patients were analyzed using (1)H NMR spectroscopy, and the NMR spectra were examined using partial least squares-discriminant analysis (PLS-DA)...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27889102/analysis-of-gene-expression-and-regulation-implicates-c2h9orf152-has-an-important-role-in-calcium-metabolism-and-chicken-reproduction
#5
Long Liu, Yanfeng Fan, Zhenhe Zhang, Chan Yang, Tuoyu Geng, Daoqing Gong, Zhuocheng Hou, Zhonghua Ning
The reproductive system of a female bird is responsible for egg production. The genes highly expressed in oviduct are potentially important. From RNA-seq analysis, C2H9orf152 (an orthologous gene of human C9orf152) was identified as highly expressed in chicken uterus. To infer its function, we obtained and characterized its complete cDNA sequence, determined its spatiotemporal expression, and probed its transcription factor(s) through pharmaceutical approach. Data showed that the complete cDNA sequence was 1468bp long with a 789bp of open reading frame...
November 11, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27878482/an-in-vitro-approach-for-water-quality-determination-activation-of-nf-%C3%AE%C2%BAb-as-marker-for-cancer-related-stress-responses-induced-by-anthropogenic-pollutants-of-drinking-water
#6
Luis F Spitta, Sebastian Diegeler, Christa Baumstark-Khan, Christine E Hellweg
Epidemiological studies show that there is a link between urban water pollution and increase in human morbidity and mortality. With the increase in number of new substances arising from the chemical, pharmaceutical, and agricultural industries, there is an urgent need to develop biological test systems for fast evaluation of potential risks to humans and the environmental ecosystems. Here, a combined cellular reporter assay based on the cellular survival and the stress-induced activation of the survival-promoting factor nuclear factor κB (NF-κB) and its use for the detection of cytotoxicity and cancer-related stress responses is presented...
November 22, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27852111/ror%C3%AE-t-inhibitors-as-potential-back-ups-for-the-phase-ii-candidate-vtp-43742-from-vitae-pharmaceuticals-patent-evaluation-of-wo2016061160-and-us20160122345
#7
Christian Gege
Retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt or RORc2) is a key transcription factor for the differentiation of naïve proinflammatory CD4(+) T cells and the production of T helper-17 (TH17) cells. Inhibiting RORγt activity is thought to be beneficial in targeting a variety of inflammatory and autoimmune disorders. Recently Vitae Pharmaceuticals (to be acquired by Allergan) reported positive top-line results from a Phase 2a clinical trial of RORγt inhibitor VTP-43742 in psoriatic patients...
November 17, 2016: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27829821/enhanced-nmr-discrimination-of-pharmaceutically-relevant-molecular-crystal-forms-through-fragment-based-ab-initio-chemical-shift-predictions
#8
Joshua D Hartman, Graeme M Day, Gregory J O Beran
Chemical shift prediction plays an important role in the determination or validation of crystal structures with solid-state nuclear magnetic resonance (NMR) spectroscopy. One of the fundamental theoretical challenges lies in discriminating variations in chemical shifts resulting from different crystallographic environments. Fragment-based electronic structure methods provide an alternative to the widely used plane wave gauge-including projector augmented wave (GIPAW) density functional technique for chemical shift prediction...
November 2, 2016: Crystal Growth & Design
https://www.readbyqxmd.com/read/27822623/-esc-and-aha-guidelines-2015-on-endocarditis-in-competition-or-synchrony
#9
Bernhard Maisch
In the 2015 guidelines of the European Society of Cardiology (ESC) and the American Heart Association (AHA) on infective endocarditis, the diagnostics are based on the modified Duke criteria. The diagnosis can be confirmed by a combination of micro-organisms demonstrated in culture or in situ, with the detection of valvular lesions or abscess formation by an imaging modality using echocardiography, positron emission tomography computed tomography (PET/CT), cardio-CT or nuclear medical methods. The management should be further improved by an interdisciplinary endocarditis team in a specifically designated reference center...
December 2016: Herz
https://www.readbyqxmd.com/read/27813010/designing-dna-nanotube-liquid-crystals-as-a-weak-alignment-medium-for-nmr-structure-determination-of-membrane-proteins
#10
John Min, William M Shih, Gaëtan Bellot
Thirty percent of the human proteome is composed of membrane proteins that can perform a wide range of cellular functions and communications. They represent the core of modern medicine as the targets of about 50 % of all prescription pharmaceuticals. However, elucidating the structure of membrane proteins has represented a constant challenge, even in the modern era. To date, only a few hundred high-resolution structural models of membrane proteins are available. This chapter describes the emergence of DNA nanotechnology as a powerful tool for the structural characterization of membrane protein using solution-state nuclear magnetic resonance (NMR) spectroscopy...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27806319/ammonium-tetrathiomolybdate-treatment-targets-the-copper-transporter-atp7a-and-enhances-sensitivity-of-breast-cancer-to-cisplatin
#11
Cristine L Chisholm, Haitao Wang, Ada Hang-Heng Wong, Guelaguetza Vazquez-Ortiz, Weiping Chen, Xiaoling Xu, Chu-Xia Deng
Cisplatin is an effective breast cancer drug but resistance often develops over prolonged chemotherapy. Therefore, we performed a candidate approach RNAi screen in combination with cisplatin treatment to identify molecular pathways conferring survival advantages. The screen identified ATP7A as a therapeutic target. ATP7A is a copper ATPase transporter responsible for intercellular movement and sequestering of cisplatin. Pharmaceutical replacement for ATP7A by ammonium tetrathiomolybdate (TM) enhanced cisplatin treatment in breast cancer cells...
October 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27789032/improving-biopharmaceutical-properties-of-vinpocetine-through-cocrystallization
#12
Samuel Golob, Miranda Perry, Matteo Lusi, Michele R Chierotti, Iztok Grabnar, Lucia Lassiani, Dario Voinovich, Michael J Zaworotko
Vinpocetine is a poorly water soluble weakly basic drug (pKa = 7.1) used for the treatment of several cerebrovascular and cognitive disorders. Because existing formulations exhibit poor bioavailability and scarce absorption, a dosage form with improved pharmacokinetic properties is highly desirable. Cocrystallization represents a promising approach to generate diverse novel crystal forms and to improve the aqueous solubility and in turn the oral bioavailability. In this article, a novel ionic cocrystal of vinpocetine is described, using boric acid as a coformer, and fully characterized (by means of differential scanning calorimetry, solid-state nuclear magnetic resonance, powder and single-crystal X-ray diffraction, and powder dissolution test)...
October 24, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27754668/predicting-molecular-crystal-properties-from-first-principles-finite-temperature-thermochemistry-to-nmr-crystallography
#13
Gregory J O Beran, Joshua D Hartman, Yonaton N Heit
Molecular crystals occur widely in pharmaceuticals, foods, explosives, organic semiconductors, and many other applications. Thanks to substantial progress in electronic structure modeling of molecular crystals, attention is now shifting from basic crystal structure prediction and lattice energy modeling toward the accurate prediction of experimentally observable properties at finite temperatures and pressures. This Account discusses how fragment-based electronic structure methods can be used to model a variety of experimentally relevant molecular crystal properties...
October 18, 2016: Accounts of Chemical Research
https://www.readbyqxmd.com/read/27734288/optimization-of-levan-production-by-cold-active-bacillus-licheniformis-ant-179-and-fructooligosaccharide-synthesis-by-its-levansucrase
#14
Janifer Raj Xavier, Karna Venkata Ramana
Fructooligosaccharides (FOS) and levan attract much attention due to a wide range of applications in food technology and pharmaceutical and cosmetic industry. Bacillus licheniformis ANT 179, isolated from Antarctica soil, produced levansucrase and levan in a medium containing sucrose as carbon substrate. In this study, characterization of levansucrase and production of short-chain FOS and levan were investigated. Temperature and pH optimum of the enzyme were found to be 60 °C and pH 6.0, respectively. The optimization of fermentation conditions for levan production using sugarcane juice by response surface methodology (RSM) was carried out...
October 12, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27723751/nuclear-receptors-control-pro-viral-and-antiviral-metabolic-responses-to-hepatitis-c-virus-infection
#15
Gahl Levy, Naomi Habib, Maria Angela Guzzardi, Daniel Kitsberg, David Bomze, Elishai Ezra, Basak E Uygun, Korkut Uygun, Martin Trippler, Joerg F Schlaak, Oren Shibolet, Ella H Sklan, Merav Cohen, Joerg Timm, Nir Friedman, Yaakov Nahmias
Viruses lack the basic machinery needed to replicate and therefore must hijack the host's metabolism to propagate. Virus-induced metabolic changes have yet to be systematically studied in the context of host transcriptional regulation, and such studies shoul offer insight into host-pathogen metabolic interplay. In this work we identified hepatitis C virus (HCV)-responsive regulators by coupling system-wide metabolic-flux analysis with targeted perturbation of nuclear receptors in primary human hepatocytes. We found HCV-induced upregulation of glycolysis, ketogenesis and drug metabolism, with glycolysis controlled by activation of HNF4α, ketogenesis by PPARα and FXR, and drug metabolism by PXR...
October 10, 2016: Nature Chemical Biology
https://www.readbyqxmd.com/read/27722689/sargassum-fusiforme-polysaccharides-activate-antioxidant-defense-by-promoting-nrf2-dependent-cytoprotection-and-ameliorate-stress-insult-during-aging
#16
Peichao Chen, Dan He, Ya Zhang, Shanshan Yang, Liujun Chen, Shengqin Wang, Huixi Zou, Zhiyong Liao, Xu Zhang, Mingjiang Wu
Aging is a complex issue, which results in a progressive decline process in cellular protection and physiological functions. Illustrating the causes of aging and pharmaceutical interference with the aging process has been a pivotal issue for thousands of years. Sargassum fusiforme (S. fusiforme), a kind of brown alga, is also named the "longevity vegetable" as it is not only a kind of food, but also used as an herb in traditional Chinese Medicine for maintaining health and treatment of thyroid disease, cardiovascular disease and so on...
October 10, 2016: Food & Function
https://www.readbyqxmd.com/read/27719665/plastid-molecular-pharming-ii-production-of-biopharmaceuticals-by-plastid-transformation
#17
Henrik Aronsson, Petter Larsson, Sandra Bains
Higher plants have been used in medicine throughout human history. While traditional medicinal uses relied on compounds produced naturally by plants, recent advances have enabled the use of plant-based factories to produce diverse agents including pharmaceuticals, antibiotics, and vaccines. The genes responsible for the production of these substances can be either transiently expressed in plants or integrated into their nuclear genome or plastid genome (plastome) by genetic transformation. This review focuses on the application of plastid transformation of higher plants to produce biopharmaceuticals for human applications that are neither antibiotics nor vaccines...
October 4, 2016: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/27711465/-35-cl-dynamic-nuclear-polarization-solid-state-nmr-of-active-pharmaceutical-ingredients
#18
David A Hirsh, Aaron J Rossini, Lyndon Emsley, Robert W Schurko
In this work, we show how to obtain efficient dynamic nuclear polarization (DNP) enhanced (35)Cl solid-state NMR (SSNMR) spectra at 9.4 T and demonstrate how they can be used to characterize the molecular-level structure of hydrochloride salts of active pharmaceutical ingredients (APIs) in both bulk and low wt% API dosage forms. (35)Cl SSNMR central-transition powder patterns of chloride ions are typically tens to hundreds of kHz in breadth, and most cannot be excited uniformly with high-power rectangular pulses or acquired under conditions of magic-angle spinning (MAS)...
September 21, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27708429/structural-basis-for-ppar-partial-or-full-activation-revealed-by-a-novel-ligand-binding-mode
#19
Davide Capelli, Carmen Cerchia, Roberta Montanari, Fulvio Loiodice, Paolo Tortorella, Antonio Laghezza, Laura Cervoni, Giorgio Pochetti, Antonio Lavecchia
The peroxisome proliferator-activated receptors (PPARs) are nuclear receptors involved in the regulation of the metabolic homeostasis and therefore represent valuable therapeutic targets for the treatment of metabolic diseases. The development of more balanced drugs interacting with PPARs, devoid of the side-effects showed by the currently marketed PPARγ full agonists, is considered the major challenge for the pharmaceutical companies. Here we present a structure-based virtual screening approach that let us identify a novel PPAR pan-agonist with a very attractive activity profile and its crystal structure in the complex with PPARα and PPARγ, respectively...
October 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27693965/dissolution-dynamic-nuclear-polarization-capability-study-with-fluid-path
#20
Ronja M Malinowski, Kasper W Lipsø, Mathilde H Lerche, Jan H Ardenkjær-Larsen
Signal enhancement by hyperpolarization is a way of overcoming the low sensitivity in magnetic resonance; MRI in particular. One of the most well-known methods, dissolution Dynamic Nuclear Polarization, has been used clinically in cancer patients. One way of ensuring a low bioburden of the hyperpolarized product is by use of a closed fluid path that constitutes a barrier to contamination. The fluid path can be filled with the pharmaceuticals, i.e. imaging agent and solvents, in a clean room, and then stored or immediately used at the polarizer...
September 22, 2016: Journal of Magnetic Resonance
keyword
keyword
117097
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"