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https://www.readbyqxmd.com/read/29037162/feasibility-of-a-multi-modal-exercise-program-on-cognition-in-older-adults-with-type-2-diabetes-a-pilot-randomised-controlled-trial
#1
M L Callisaya, R M Daly, J E Sharman, D Bruce, T M E Davis, T Greenaway, M Nolan, R Beare, M G Schultz, T Phan, L C Blizzard, V K Srikanth
BACKGROUND: Type 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain structure in people with T2D. METHODS: A 6-month pilot parallel RCT of a progressive aerobic- and resistance-training program versus a gentle movement control group in people with T2D aged 50-75 years (n = 50) at the University of Tasmania, Australia...
October 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29036825/the-emergence-of-a-new-conceptual-framework-for-alzheimer-s-disease
#2
Dubois Bruno
The New Criteria for the diagnosis of Alzheimer's disease (AD), published by a group of experts in 2007, have resulted in a revolution in the comprehension of the disease. Before 2007, the diagnosis of AD dementia was done through a process of exclusion: it was considered in the case of patients with a dementia syndrome without identified etiologies. This traditional algorithm had three major limitations that penalize the disease: 1) a low accuracy of the performance which may share responsibility for negative results in clinical trials; 2) a late identification of the patients only when they reach the threshold of dementia which may delay the activation of optimal care; and last but not least, 3) an absence of clear recognition of AD as a disease because of the lack of specific arguments for its identification...
October 7, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29033311/brain-gray-matter-changes-in-type-2-diabetes-mellitus-a-meta-analysis-of-whole-brain-voxel-based-morphometry-study
#3
Guangyao Wu, Lin Lin, Qing Zhang, Jianlin Wu
AIMS: We aimed to identify alterations in global gray matter volumes (GMV) and consistent regional abnormalities in T2DM patients via meta-analysis. METHODS: A systematic search for relevant studies indexed in the PubMed and Embase databases was conducted. A quantitative meta-analysis of volumetric and whole-brain VBM data was conducted using STATA v.12.0 and AES-SDM software packages, respectively. RESULTS: A total of 15 volumetric studies and five VBM studies of GM in T2DM patients vs...
September 15, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29028481/neuropsychiatric-symptoms-as-risk-factors-of-dementia-in-a-mexican-population-a-10-66-dementia-research-group-study
#4
Isaac Acosta, Guilherme Borges, Rebeca Aguirre-Hernandez, Ana Luisa Sosa, Martin Prince
INTRODUCTION: Cognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence. METHODS: We analyzed the association between neuropsychiatric symptoms and incident dementia in a cohort of 1355 Mexican older adults from the general population over 3 years of follow-up, modeling cumulative incidence ratios using Poisson models...
October 10, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/29025435/withania-somnifera-as-a-potential-candidate-to-ameliorate-high%C3%A2-fat-diet-induced-anxiety-and-neuroinflammation
#5
Taranjeet Kaur, Gurcharan Kaur
BACKGROUND: The epidemic of obesity has reached alarming levels in both developing and developed nations. Excessive calorie intake and sedentary lifestyle due to technological advancements are the main causal factors for overweight and obesity among the human population. Obesity has been associated with a number of co-morbidities such as hypertension, type 2 diabetes mellitus, cardiovascular diseases, and neurodegeneration and dementia. The progression of neurological disorders in obese subjects has been mainly attributed to neuroinflammation...
October 12, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29023081/frailty-predicts-adverse-outcomes-in-older-people-with-diabetes
#6
Joanna Ulley, Ahmed H Abdelhafiz
The greatest proportional increase in the number of people with diabetes by age group is predicted to occur in those aged 60 to 79. In older people living with diabetes, geriatric syndromes, which indicate frailty, are emerging as a third category of complications in addition to the traditional microvascular and macrovascular sequelae. Frailty is defined by the presence of three or more phenotypes (weight loss, weakness, decreased physical activity, exhaustion and slow gait speed). The presence of one or two phenotypes describes a pre-frail state, and the absence of phenotypes describes a non-frail person...
January 2017: Practitioner
https://www.readbyqxmd.com/read/28992666/-an-increase-in-cases-of-bladder-tamponade-due-to-cystitis-among-elderly-women-and-clinical-background-factors
#7
Kazunari Tsuchihashi, Yuki Makino, Masahiro Emura, Kazutaka Kida, Yosuke Shimizu, Sojun Kanamaru, Ryo Iguchi, Tetsuya Noguchi, Miharu Sasaki, Noriyuki Ito
Bladder tamponade is thought to be caused mainly by bladder cancer or radiation cystitis. However, in women, it may often be caused by cystitis in clinical settings. This has not been noted in previous reports of bladder tamponade in Japan. Thus, we retrospectively analyzed the clinical features of 83 male and 41 female patients with bladder tamponade. Seventy-four patients were treated at Nishi-Kobe Medical Center between April 2005 and March 2015, and 50 were treated at Shizuoka City Shizuoka Hospital between November 2008 and March 2015...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28991365/arterial%C3%A2-stiffness-cognitive-impairment-and-dementia-real-risk-or-confounding-factor
#8
REVIEW
M Florencia Iulita, Adrián Noriega de la Colina, Hélène Girouard
Large artery stiffness is a frequent condition that arises with aging, and is accelerated by the presence of co-morbidities like hypertension, obesity and diabetes. Although epidemiological studies have indicated an association between arterial stiffness, cognitive impairment and dementia, the precise effects of stiff arteries on the brain remains obscure. This is because, in humans, arterial stiffness is often accompanied by other factors such as age, high blood pressure, atherosclerosis and inflammation, which could themselves damage the brain independently of stiffness...
October 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28990110/effects-of-butylphthalide-on-cognitive-decline-in-diabetic-rats
#9
Zhiyan Tian, Jinhua Wang, Yan Wang, Miao Zhang, Yuying Zhou
Butylphthalide, a component extracted from seeds of Chinese celery, is an effective neuroprotective agent used for the treatment of ischemic stroke and dementia. Diabetes may cause central nervous system damage, and diabetes is closely associated with dementia. The aim of the present study was to investigate the effects of butylphthalide on cognitive impairment in a streptozotocin‑induced diabetic rat model, and the underlying mechanisms of action. A total of 30 healthy male Sprague Dawley rats were randomly divided into the following 2 groups: Normal control (NC; n=10) and diabetes model (DM) groups (n=20)...
October 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28960500/online-assessment-of-risk-factors-for-dementia-and-cognitive-function-in-healthy-adults
#10
J Huntley, A Corbett, K Wesnes, H Brooker, R Stenton, A Hampshire, C Ballard
OBJECTIVE: Several potentially modifiable risk factors for cognitive decline and dementia have been identified, including low educational attainment, smoking, diabetes, physical inactivity, hypertension, midlife obesity, depression, and perceived social isolation. Managing these risk factors in late midlife and older age may help reduce the risk of dementia; however, it is unclear whether these factors also relate to cognitive performance in older individuals without dementia. METHOD: Data from 14 201 non-demented individuals aged >50 years who enrolled in the online PROTECT study were used to examine the relationship between cognitive function and known modifiable risk factors for dementia...
September 27, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28958013/fracture-risk-assessment-in-long-term-care-frail-development-and-validation-of-a-prediction-model
#11
Sarah D Berry, Andrew R Zullo, Yoojin Lee, Vincent Mor, Kevin W McConeghy, Geetanjoli Banerjee, Ralph B D'Agostino, Lori Daiello, David Dosa, Douglas P Kiel
Background: Strategies used to predict fracture in community-dwellers may not be useful in the nursing home (NH). Our objective was to develop and validate a model (Fracture Risk Assessment in Long-term Care [FRAiL]) to predict the 2-year risk of hip fracture in NH residents using readily available clinical characteristics. Methods: The derivation cohort consisted of 419,668 residents between May 1, 2007 and April 30, 2008 in fee-for service Medicare. Hip fractures were identified using Part A diagnostic codes...
August 31, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28956423/influence-of-glucose-metabolism-on-cognitive-function-of-patients-with-acute-small-artery-occlusion
#12
L P Zhai, X L Zhang, Q B Guan, B Yu, Y P Wang, H P Shen, X X Yu, D D Wang, Y Zhu
The aim of this study was to evaluate the influence of abnormal glucose metabolism on cognitive function of patients with acute small-arterial occlusion (SAO). The present study included 1,211 patients, with small-artery occlusion according to the Trial of Org 10172 in acute stroke treatment (TOAST) classification, admitted between March 2014 and December 2016 to The Second Hospital of Jiaxing. According to cognitive function, the patients were divided into a group of normal cognitive function, a mild cognitive impairment group (MCI group) and a dementia group...
July 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28956331/phosphodiesterase-4b-as-a-therapeutic-target-for-cognitive-impairment-and-obesity-related-metabolic-diseases
#13
Steven J Clapcote
People in modern, affluent societies are living longer but also becoming increasingly overweight. With increased life expectancy comes increased risk of developing age-related cognitive decline and neurodegenerative diseases, such that an increasing proportion of life may be lived with cognitive impairment as age increases. Obesity is associated with poorer cognitive function in elderly subjects, and often leads to ill-health arising from various complications such as metabolic syndrome and type-2 diabetes mellitus...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28954880/metformin-vs-sulfonylurea-use-and-risk-of-dementia-in-us-veterans-aged-%C3%A2-65-years-with-diabetes
#14
Ariela R Orkaby, Kelly Cho, Jean Cormack, David R Gagnon, Jane A Driver
OBJECTIVE: To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS: This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therapy. To account for confounding by indication, we developed a propensity score (PS) and used inverse probability of treatment weighting (IPTW) methods...
September 27, 2017: Neurology
https://www.readbyqxmd.com/read/28953609/incidence-and-risk-factors-of-leukoaraiosis-from-4683-hospitalized-patients-a-cross-sectional-study
#15
Qing Lin, Wen-Qing Huang, Qi-Lin Ma, Cong-Xia Lu, Sui-Jun Tong, Jin-Hu Ye, Hui-Nuan Lin, Long Gu, Ke-Hui Yi, Liang-Liang Cai, Chi-Meng Tzeng
Leukoaraiosis (LA) refers to white matter hyperintensities or white matter lesions (WMLs) on magnetic resonance imaging (MRI) scans of the brain; this disease is associated with an increased risk of stroke, dementia, and cognitive decline. The aims of the study are to assess the incidence of LA and its associated risk factors in a Chinese population.A hospital-based cross-sectional study was conducted that included 4683 patients who were 40 years or older. Data collected included age, sex, hypertension, diabetes, smoking, drinking, homocysteine (HCY), and low-density lipoprotein cholesterol (LDL-C) levels in the blood in addition to brain MRI information...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28951388/retinal-microperimetry-a-new-tool-for-identifying-type-2-diabetic-patients-at-risk-of-developing-alzheimer%C3%A2-s-disease
#16
Andreea Ciudin, Olga Simó-Servat, Cristina Hernández, Gabriel Arcos, Susana Diego, Ángela Sanabria, Óscar Sotolongo, Isabel Hernández, Mercè Boada, Rafael Simó
Type 2 diabetes is associated with a high risk of cognitive impairment and dementia. Therefore, strategies aimed at identifying those patients at risk of dementia are needed. Given that the retina is a brain-derived tissue it may provide a non-invasive way of examining brain pathology. The aims of the study were to evaluate whether retinal sensitivity: 1) Correlates with the specific parameters of brain imaging related to cognitive impairment; 2) Discriminates diabetic patients with mild cognitive impairment (MCI) from those with normal cognition and Alzheimer's disease (AD)...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28949318/psychogeriatric-diagnoses-in-old-people-s-homes-and-negative-health-behavior
#17
Spomenka Tomek-Roksandić, Ivana Popek, Nada Tomasović Mrčela, Zvonimir Šostar, Branko Kolarić, Nina Smolej Narančić, Ana Stavljenić Rukavina, Mate Ljubičić
BACKGROUND: The study was designed as a gerontologic-public health analysis of the relationship between the leading and accompanying psychogeriatric diagnoses and negative health behaviors recorded in the old people's home users, with the aim to evaluate and redefine gerontologic-public health priorities and geroprophylactic measures, with special reference to persons suffering from Alzheimer's disease and other dementias. SUBJECT AND METHODS: Gerontologic-public health indicators obtained by monitoring health care needs of the elderly in specific institutional primary health care at 10 old people's homes (N=1185) in Croatia in 2013 were analyzed using the professional methodology developed at Department of Health Gerontology, Andrija Štampar Teaching Institute of Public Health (Registry List 1 that refers to monitoring specific primary health care needs of elderly at old people's homes)...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28945135/hospital-admissions-in-people-with-alzheimer-s-disease-or-senile-dementia-according-to-type-2-diabetes-status-an-observational-10-year-study
#18
José M de Miguel-Yanes, Rodrigo Jiménez-García, Valentín Hernández-Barrera, Manuel Méndez-Bailón, Javier de Miguel-Díez, Nuria Muñoz-Rivas, David Ezpeleta, Ana López-de-Andrés
We aimed to describe admission rates and outcomes of hospitalized people with Alzheimer's disease (AD) or senile dementia stratified by type 2 diabetes (T2D) in Spain, 2004 to 2013 (N = 541 858, 143 501 [26.5%] of whom had T2D). We excluded alternative causes of dementia. Hospitalization rates were higher in people with T2D (130.5 vs 91.5 cases/10(5) people). People older than 84 years and comorbidity increased over time. Crude inhospital mortality (IHM) decreased over time both in people with and without T2D (all P values <...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28944218/diabetes-mitigates-the-role-of-memory-complaint-in-predicting-dementia-risk-results-from-the-prevention-of-alzheimer-s-disease-with-vitamin-e-and-selenium-study
#19
X Zhang, F A Schmitt, A M Caban-Holt, X Ding, R J Kryscio, E Abner
BACKGROUND: Subjective memory complaints (SMCs) are associated with increased risk of dementia in older adults, but the role of comorbidities in modifying this risk is unknown. OBJECTIVES: To assess whether comorbidities modify estimated dementia risk based on SMCs. DESIGN: The Prevention of Alzheimer's Disease with Vitamin E and Selenium Study (PREADVISE) was designed as an ancillary study to the Selenium and Vitamin E Cancer Prevention Trial (SELECT), a randomized, multi-center prostate cancer prevention trial with sites in the Unites States, Puerto Rico, and Canada...
2017: Journal of Prevention of Alzheimer's Disease
https://www.readbyqxmd.com/read/28936138/prevalence-and-overlap-of-disease-management-program-diseases-in-older-hospitalized-patients
#20
Helle Gybel Juul-Larsen, Janne Petersen, Ditte Maria Sivertsen, Ove Andersen
Many countries, like Denmark, have tailored Disease Management Programs (DMPs) based on patients having single chronic diseases [defined institutionally as "program diseases" (PDs)], which can complicate treatment for those with multiple chronic diseases. The aims of this study were (a) to assess the prevalence and overlap among acutely hospitalized older medical patients of PDs defined by the DMPs, and (b) to examine transitions between different departments during hospitalization and mortality and readmission within two time intervals among patients with the different PDs...
September 2017: European Journal of Ageing
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