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acne inverse

Joyce H Park, Amanda Bienenfeld, Seth J Orlow, Arielle R Nagler
BACKGROUND: Little is known about how dermatologists prescribe hormonal antiandrogen acne treatment (HAAT). OBJECTIVE: The aim of this study was to investigate dermatologists' HAAT-prescribing habits and HAAT's impact on systemic antibiotic use in women with acne. METHODS: We performed a retrospective study at an academic medical center of female patients receiving HAAT (combined oral contraceptive [COC], spironolactone) for acne from January 2005 to October 2015...
March 20, 2018: American Journal of Clinical Dermatology
Mohammed Abu El-Hamd, Moustafa A El Taieb, Hassan M Ibrahim, Sanaa S Aly
BACKGROUND/OBJECTIVES: Acne vulgaris is a common inflammatory skin disease. Vitamin D deficiency plays a role in many inflammatory skin diseases. It may play a role in pathogenesis of acne vulgaris. This study aimed to assess serum levels of 25 hydroxy vitamin D in patients with acne vulgaris before and after treatment with isotretinoin and its relation with acne vulgaris severity. METHODS: Ninety patients with acne vulgaris and 60 age-sex matched healthy subject as controls have been recruited in this study...
February 20, 2018: Journal of Cosmetic Dermatology
Wojciech Francuzik, Kristin Franke, Ralf R Schumann, Guido Heine, Margitta Worm
The microbiome may influence disease severity in atopic dermatitis. The skin of atopic dermatitis patients and healthy individuals was sampled in a standardized manner and the microbial composition analysed using next-generation sequencing. Optical density measurements were used to investigate bacterial growth under defined conditions in vitro. Lesional skin from patients with atopic dermatitis had a higher abundance of S. aureus and reduced quantities of Propionibacterium acnes and Lawsonella clevelandensis compared with non-lesional skin...
January 30, 2018: Acta Dermato-venereologica
Chiyoko N Inoue, Yoshiko Tanaka, Nobuko Tabata
Trisomy 13 (T13) is a congenital chromosomal disorder that is usually fatal within 2 years of birth, and only a few patients have been reported to reach adolescence. Here, we report a male long-term survivor of T13, currently 15 years of age, with a several-year history of extensive acne conglobata (AC) with abscesses on the face and neck. Methicillin-resistant Staphylococcus aureus was consistently isolated from the pustular lesions. Serum IgM levels were extremely low at 10 mg/dl. There were no abnormalities in neutrophil and total B cell number, or in serum IgA and IgG levels...
May 7, 2017: American Journal of Medical Genetics. Part A
Mohammad H Kowsari, Leila Tohidifar
All-atom molecular dynamics (MD) simulations of the ionic liquid (IL) 1-hexyl-2,3-dimethylimidazolium bis(fluorosulfonyl)imide ([C6mmim][FSI]) and its binary mixtures with acetonitrile (ACN) have been reported for the first time. The presence of ACN as a cosolvent, similar to the effect of increasing temperature, causes enhancements in the ion translational motion and fluidity of the IL, leading to significant improvement of ionic conductivity and self-diffusion, which is well explained by a microscopic structural analysis...
October 7, 2016: Journal of Physical Chemistry. B
Seul-Ki Lim, Jeong-Min Ha, Young-Ho Lee, Young Lee, Young-Joon Seo, Chang-Deok Kim, Jeung-Hoon Lee, Myung Im
BACKGROUND: Vitamin D plays an important role in the immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis and psoriasis. Acne is a common inflammatory skin disease; however, the association with vitamin D remains unclear. OBJECTIVES: We evaluated vitamin D levels in patients with acne to determine the effect of vitamin D supplementation. METHODS: This study included 80 patients with acne and 80 healthy controls...
2016: PloS One
Uwe Wollina, Dana Langner, Birgit Heinig, Andreas Nowak
BACKGROUND: Acne inversa (hidradentitis suppurativa; AI) is a severe chronic relapsing inflammatory skin disease of unknown cause. Anogenital AI has the strongest negative impact on quality of life and causes great disability. OBJECTIVES: We analyzed patients, comorbities, outcome of extensive surgery, and possible adverse effects. PATIENTS AND METHODS: We included patients from January 2000 to March 2015 with anogenital AI Hurley grade III...
January 2017: International Journal of Dermatology
Aslı Aksu Çerman, Ezgi Aktaş, İlknur Kıvanç Altunay, Janset Erkul Arıcı, Aysın Tulunay, Feyza Yener Ozturk
BACKGROUND: There is increasing evidence to support the relationship between acne vulgaris and diet. OBJECTIVE: The aim of this study was to investigate possible associations among dietary glycemic index, glycemic load, milk consumption, insulin resistance, and adiponectin levels in the pathogenesis of acne vulgaris. METHODS: The dietary glycemic index, glycemic load, milk consumption, fasting glucose, insulin, insulin-like growth factor)-1, insulin-like growth factor binding protein-3, adiponectin, and homeostasis model assessment of insulin resistance values of 50 patients with acne vulgaris and 36 healthy control subjects were measured...
July 2016: Journal of the American Academy of Dermatology
Ha Son Nguyen, Ninh Doan, Michael Gelsomino, Saman Shabani, Wade Mueller
BACKGROUND: When wounds are benign, diagnosis of deep brain stimulation (DBS) electrode infection and associated intraparenchymal infection can be challenging. Only a couple, such cases exist in literature. Since infections of the central nervous system can be life-threatening, prompt diagnosis is necessary to prevent neurological injury. Employed within the appropriate context, magnetic resonance imaging (MRI) of the brain, as well as laboratory data and clinical presentation, may help guide diagnosis...
2016: Surgical Neurology International
J Rafael Montenegro-Burke, Jackson M Bennett, John A McLean, David M Hercules
In various polymerization processes, the formation of a wide variety of chains, not only in length but also in chemical composition, broadly complicates comprehensive polymer characterization. In this communication, we compare different stationary and mobile phases for the analysis of complex polymer mixtures via size-exclusion chromatography-mass spectrometry (SEC-MS). To the best of our knowledge, we report novel chromatographic effects for the separation of linear and cyclic oligomers for polyesters (PE) and polyurethanes (PUR)...
January 2016: Analytical and Bioanalytical Chemistry
Steven S Coughlin
Isotretinoin was approved by the Food and Drug Administration (FDA) in 1982 and revolutionized acne therapy. Soon afterwards, case reports appeared suggesting a link between inflammatory bowel disease and use of isotretinoin. As reviewed in this article, an increasing number of case-control and prospective (cohort) studies have been reported that examined associations between use of isotretinoin and inflammatory bowel disease. Published epidemiologic studies of the use of isotretinoin and risk of Crohn's disease and ulcerative colitis vary according to whether the design was a case-control study or cohort study and by other important design differences...
2015: Journal of Environment and Health Sciences
Jian Ming Hu, Ling Li, Yun Zhao Chen, Chunxia Liu, Xiaobin Cui, Liang Yin, Lan Yang, Hong Zou, Lijuan Pang, Jin Zhao, Yan Qi, Yuwen Cao, Jinfang Jiang, Weihua Liang, Feng Li
Human leukocyte antigen II (HLA-II) plays an important role in host immune responses to cancer cells. Changes in gene methylation may result in aberrant expression of HLA-II, serving a key role in the pathogenesis of Kazakh esophageal squamous cell carcinoma (ESCC). We analyzed the expression level of HLA-II (HLA-DP, -DQ, and -DR) by immunohistochemistry, as well as the methylation status of HLA-DRB1 and HLA-DQB1 by MassARRAY spectrometry in Xinjiang Kazakh ESCC. Expression of HLA-II in ESCC was significantly higher than that in cancer adjacent normal (ACN) samples (P < 0...
October 2014: Epigenetics: Official Journal of the DNA Methylation Society
Syed Haider Naqvi, Ava Moore, Kris Bevilacqua, Sanam Lathief, Joanne Williams, Nighat Naqvi, Lubna Pal
The aim of this study is to assess the prevalence and predictors of depressive symptoms in women with polycystic ovary syndrome (PCOS). In a cross-sectional study of 114 women seeking consultation for symptoms of PCOS (menstrual irregularity, hirsutism, and/or acne), personal and family history of depression (HD and FHD respectively) were enquired. Vitamin D status (n = 104) and manifest depressive symptoms assessed by personal health questionnaire (PHQ) (MD) were evaluated in a subset (85). Relationships between HD and MD with PCOS symptoms, FHD, and vitamin D status were assessed using adjusted analyses...
February 2015: Archives of Women's Mental Health
R Bissonnette, J E Risch, K J McElwee, P Marchessault, C Bolduc, S Nigen, C Maari
BACKGROUND/PURPOSE: Sebum is thought to play an important role in acne vulgaris and sebum excretion rate (SER) is often used as a marker of efficacy in acne studies. This study explored factors that could induce intra-subject variability in SER. METHODS: SER was measured twice, 7 days apart, on the forehead of 40 healthy subjects. At each visit, the following parameters were also evaluated: serum androgen levels, 5-alpha-reductase type I gene expression, forehead temperature, sleep habits, diet, facial washing routine, and UV exposure...
February 2015: Skin Research and Technology
Ruben G Cremers, Katja K Aben, Sita H Vermeulen, Martin den Heijer, Inge M van Oort, Peter C van de Kerkhof, Jack A Schalken, Lambertus A Kiemeney
OBJECTIVE: Some studies have suggested an inverse association between acne vulgaris and the acne-related bacterium Propionibacterium acnes and prostate cancer (PCa). Self-reported acne might be an easily obtainable marker to identify men at relatively low risk of PCa and might be incorporated into PCa risk calculators. This study aimed to evaluate the association between self-reported acne and PCa in a large case-referent study. METHODS AND MATERIALS: The case group comprised 942 patients with PCa recruited from a population-based cancer registry in 2003 to 2006, 647 of whom met the criteria for aggressive PCa...
October 2014: Urologic Oncology
Anika C Jahns, Hassan Killasli, Daniel Nosek, Bertil Lundskog, Anna Lenngren, Zhanna Muratova, Lennart Emtestam, Oleg A Alexeyev
Hidradenitis suppurativa (acne inverse) (HS) is a chronic skin disease primarily affecting hair follicles. The aetiology of HS is unknown, but infection is believed to play some role. This retrospective study investigated the microbial colonization directly in skin appendices in HS skin samples. Archival samples from 27 patients with HS were screened by immunofluorescence labelling with monoclonal and polyclonal antibodies against Gram-positive bacteria, Propionibacterium acnes and Propionibacterium granulosum...
September 2014: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
M L Hounsgaard, L B Håkonsen, A Vested, A M Thulstrup, J Olsen, J P Bonde, E A Nohr, C H Ramlau-Hansen
Maternal overweight and obesity in pregnancy has been associated with earlier age of menarche in daughters as well as reduced semen quality in sons. We aimed at investigating pubertal development in sons born by mothers with a high body mass index (BMI). The study included 2522 sons of mothers that during pregnancy in 1984-1987 were enrolled in a mother-child cohort and gave information on their pre-pregnancy height and weight from which we calculated their BMI. Information on sons' pubertal development, assessed by age when starting regular shaving, voice break, acne and first nocturnal emission, was obtained from web-based questionnaires in 2005, when sons were 18-21 years old...
March 2014: Andrology
Apostolos Pappas, Jared Fantasia, Theresa Chen
This study was conducted to compare lipid components of sebum from persons from three ethnic backgrounds-Caucasian, African American and Northern Asian. Men and women with no acne in two age groups (18‒25 y and 35‒45 y) were recruited. Skin surface hydration (SkiCon 200EX and NovaMeter), barrier function (Delfin VapoMeter), high-resolution clinical imaging, self-assessments and two pairs of sebutapes on the forehead that extracted the lipids on the surface of their skin were used. Significant differences (p < 0...
April 1, 2013: Dermato-endocrinology
Noah Scheinfeld
Hidradenitis suppurativa (HS), a pathologic follicular disease, impacts patients' lives profoundly and usually occurs in isolation. The diseases with the strongest association are obesity, depression, and pain. HS is associated with many diseases including acne conglobata (AC), dissecting cellulitis, pilonidal cysts, and obesity. Pyoderma fistulans sinifica (fox den disease) appears to be the same entity as Hurley Stage 2 of 3 HS. The rate of acne vulgaris in HS patients mirrors unaffected controls. The most common, albeit still uncommon, association is with seronegative, haplotype unlinked arthritis (most importantly B27), in particular spondolyarthritis...
June 15, 2013: Dermatology Online Journal
Sanjay Singh, Baldeep Kaur Mann, Narendra K Tiwary
BACKGROUND: Case-control studies to support the concept of acne cosmetica are lacking. OBJECTIVE: To examine the association of post-adolescent acne with the use of cosmetics and cosmetic procedures. METHODS: 910 post-adolescent patients with acne and an equal number of matched controls were studied for exposure to cosmetics and cosmetic procedures. A cumulative cosmetic exposure index was stratified into four quarters of increasing exposure...
2013: Dermatology: International Journal for Clinical and Investigative Dermatology
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