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exercise training in heart failure

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https://www.readbyqxmd.com/read/29154428/muscle-wasting-and-sarcopenia-in-heart-failure-and-beyond-update-2017
#1
REVIEW
Jochen Springer, Joshua-I Springer, Stefan D Anker
Sarcopenia (loss of muscle mass and muscle function) is a strong predictor of frailty, disability and mortality in older persons and may also occur in obese subjects. The prevalence of sarcopenia is increased in patients suffering from chronic heart failure. However, there are currently few therapy options. The main intervention is resistance exercise, either alone or in combination with nutritional support, which seems to enhance the beneficial effects of training. Also, testosterone has been shown to increased muscle power and function; however, a possible limitation is the side effects of testosterone...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29128777/a-systematic-review-of-heart-failure-dyadic-self-care-interventions-focusing-on-intervention-components-contexts-and-outcomes
#2
REVIEW
Harleah G Buck, Anna Stromberg, Misook L Chung, Kristine A Donovan, Karen Harkness, Allison M Howard, Naoko Kato, Randall Polo, Lorraine S Evangelista
BACKGROUND: Having support from an informal carer is important for heart failure patients. Carers have the potential to improve patient self-care. At the same time, it should be acknowledged that caregiving could affect the carer negatively and cause emotional reactions of burden and stress. Dyadic (patient and informal carer) heart failure self-care interventions seek to improve patient self-care such as adherence to medical treatment, exercise training, symptom monitoring and symptom management when needed...
October 19, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29098623/the-igf1-pi3k-akt-signaling-pathway-in-mediating-exercise-induced-cardiac-hypertrophy-and-protection
#3
Kate L Weeks, Bianca C Bernardo, Jenny Y Y Ooi, Natalie L Patterson, Julie R McMullen
Regular physical activity or exercise training can lead to heart enlargement known as cardiac hypertrophy. Cardiac hypertrophy is broadly defined as an increase in heart mass. In adults, cardiac hypertrophy is often considered a poor prognostic sign because it often progresses to heart failure. Heart enlargement in a setting of cardiac disease is referred to as pathological cardiac hypertrophy and is typically characterized by cell death and depressed cardiac function. By contrast, physiological cardiac hypertrophy, as occurs in response to chronic exercise training (i...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29098619/the-positive-effects-of-exercise-in-chemotherapy-related-cardiomyopathy
#4
Cavarretta Elena, Mastroiacovo Giorgio, Lupieri Annik, Frati Giacomo, Peruzzi Mariangela
Anthracyclines such as doxorubicin, daunorubicin, epirubicin, mitoxantrone and idarubicin, are powerful chemotherapeutic drugs used both in children and adult populations. Their properties made them particularly suitable for a large variety of neoplasms including breast adenocarcinoma, small cell lung cancer and acute leukemia. Early and late anthracycline-induced cardiotoxicity is a well-known phenomenon, and the incidence of heart failure in patients receiving doxorubicin is 2.2%, with a mortality rate over 60% at 2 years...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29098615/the-benefits-of-exercise-training-on-aerobic-capacity-in-patients-with-heart-failure-and-preserved-ejection-fraction
#5
Danilo Marcelo Leite do Prado, Enéas Antônio Rocco
Heart failure with preserved ejection fraction (HFpEF) is defined as an inability of the ventricles to optimally accept blood from atria with blunted end- diastolic volume response by limiting the stroke volume and cardiac output. The HEpEF prevalence is higher in elderly and women and may be associated to hypertension, diabetes mellitus and atrial fibrillation. Severe exercise intolerance, manifested by dyspnea and fatigue during physical effort is the important chronic symptom in HFpEF patients, in which is the major determinant of their reduced quality of life...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29098614/exercise-based-rehabilitation-for-heart-failure-clinical-evidence
#6
Rongjing Ding
People with heart failure experience marked reduction in their exercise capacity which has detrimental effects on their activities of daily living, health-related quality of life, and ultimately their hospital ad-mission rate and mortality. Numerous cardiac rehabilitation studies have demonstrated functional benefits, improvement in quality of life and clinical outcomes from exercise training in patients with HFrEF. Based on evidences, the American College of Cardiology/American Heart Association, European Society of Cardiology, and National Institute for Health and Care Excellence(NICE) consistently recommend exercise-based cardiac rehabilitation(CR) as an effective and safe adjunct for patients with stable class II to III heart failure (HF) who do not have advanced arrhythmias and who do not have other limitations to exercise...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29079391/strategies-for-supporting-intervention-fidelity-in-the-rehabilitation-therapy-in-older-acute-heart-failure-patients-rehab-hf-trial
#7
Amy M Pastva, Pamela W Duncan, Gordon R Reeves, M Benjamin Nelson, David J Whellan, Christopher M O'Connor, Joel D Eggebeen, Leigh Ann Hewston, Karen M Taylor, Robert J Mentz, Paul B Rosenberg, Dalane W Kitzman
INTRODUCTION: Acute decompensated heart failure (ADHF) is the leading cause of hospitalization in older adults. Rehabilitation Therapy in Older Acute Heart Failure Patients (REHAB-HF) trial is a multi-site clinical trial to determine if physical rehabilitation intervention in older patients with ADHF improves physical function and reduces rehospitalizations. The REHAB-HF intervention aims to improve functional performance utilizing reproducible and progressive exercises that are individually tailored to the patient's physiological and physical capabilities...
October 24, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29074290/epigenetic-effects-of-physical-activity-in-elderly-patients-with-cardiovascular-disease
#8
REVIEW
Rina Recchioni, Fiorella Marcheselli, Roberto Antonicelli, Emanuela Mensà, Raffaella Lazzarini, Antonio Domenico Procopio, Fabiola Olivieri
Cardiovascular disease (CVD) is an important public health problem affecting especially the elderly. Over the past 20years, an increasing number of studies have examined its underlying pathophysiological mechanisms and new therapies are continually being discovered. However, despite considerable progress in CVD management, mortality and morbidity remain a major healthcare concern, and frequent hospital admissions compromise the daily life and social activities of these patients. Physical activity has emerged as an important non-pharmacological adjunctive therapy for CVD in older patients, especially for heart failure patients, exerting its beneficial effects on mortality, morbidity, and functional capacity...
October 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/29066440/exercise-training-reveals-inflexibility-of-the-diaphragm-in-an-animal-model-of-patients-with-obesity-driven-heart-failure-with-a-preserved-ejection-fraction
#9
T Scott Bowen, Dominic Brauer, Natale P L Rolim, Fredrik H Bækkerud, Angela Kricke, Anne-Marie Ormbostad Berre, Tina Fischer, Axel Linke, Gustavo Justo da Silva, Ulrik Wisloff, Volker Adams
BACKGROUND: Respiratory muscle weakness contributes to exercise intolerance in patients with heart failure with a preserved ejection fraction (HFpEF)-a condition characterized by multiple comorbidities with few proven treatments. We aimed, therefore, to provide novel insight into the underlying diaphragmatic alterations that occur in HFpEF by using an obese cardiometabolic rat model and further assessed whether exercise training performed only after the development of overt HFpEF could reverse impairments...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29051336/exercise-limitations-in-heart-failure-with-reduced-and-preserved-ejection-fraction
#10
David C Poole, Russell S Richardson, Mark J Haykowsky, Daniel M Hirai, Timothy I Musch
The hallmark symptom of chronic heart failure (CHF) syndrome is severe exercise intolerance. Impaired perfusive and diffusive O2 transport are two of the major determinants of reduced physical capacity and lowered maximal O2 uptake (VO2max) in CHF patients. It has now become evident that this syndrome manifests two different phenotypic variations: heart failure with preserved or reduced ejection fraction (HFpEF and HFrEF, respectively). Unlike HFrEF, however, there is currently limited understanding of HFpEF pathophysiology leading to a lack of effective pharmacological treatments for this subpopulation...
October 19, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29045315/a-single-dose-of-oral-atp-supplementation-improves-performance-and-physiological-response-during-lower-body-resistance-exercise-in-recreational-resistance-trained-males
#11
Marcelo C Freitas, Jason M Cholewa, Jose Gerosa-Neto, Daniela C Gonçalves, Erico C Caperuto, Fábio S Lira, Fabrício E Rossi
The aim of this study was to investigate the acute effect of ATP supplementation on performance and physiological responses during resistance exercise in recreationally resistance trained males. Eleven men (age= 27.5±5.5 yrs, weight= 83.4±9.8 kg, height= 182±0.04 cm) completed two randomized, double-blind trials: ATP supplement condition (ATP=400mg) or a placebo condition. Thirty minutes after supplement consumption, subjects performed four sets of half-squats until momentary muscular failure at 80% of the 1RM with two minutes of recovery between sets...
October 16, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29034723/response-to-the-letter-to-the-editor-on-effect-of-yoga-versus-hydrotherapy-training-on-health-related-quality-of-life-and-exercise-capacity-in-patients-with-heart-failure-a-randomized-controlled-study
#12
Eva Hägglund, Inger Hagerman, Anna Strömberg
No abstract text is available yet for this article.
October 1, 2017: European Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/29022270/exercise-training-in-pulmonary-hypertension-and-right-heart-failure-insights-from-pre-clinical-studies
#13
Daniel Moreira-Gonçalves, Rita Ferreira-Nogueira, Mário Santos, Ana Filipa Silva, Rita Ferreira, Adelino Leite-Moreira, José Alberto Duarte, Tiago Henriques-Coelho
Exercise training (ExT) is widely used for the prevention and treatment of several chronic cardiovascular diseases. However, only recently it started to be recognized as safe and beneficial in pulmonary arterial hypertension. Despite the consistency of its favorable effects on exercise tolerance and quality of life, the mechanisms underlying these meaningful clinical improvements remain unclear. Current studies emphasize the exercise-induced changes on skeletal muscle but the impact of ExT at the level of the pulmonary circulation and right ventricle should not be overlooked...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022267/cardiac-fibrosis-the-beneficial-effects-of-exercise-in-cardiac-fibrosis
#14
Jan Kyselovič, John J Leddy
Numerous scientific findings have concluded that individuals who are active tend to develop less cardiovascular disease than those who enjoy more sedentary lifestyles. Animal models have further demonstrated that the beneficial effects of training on the heart effects of training are related to the signaling pathways of myocardial hypertrophy and fibrosis. As such, fibroblasts represent a very important population of cells within the myocardium as they play a crucial role in both cardiac development and response to injury...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022264/experimental-evidences-supporting-the-benefits-of-exercise-training-in-heart-failure
#15
Marcelo H A Ichige, Marcelo G Pereira, Patrícia C Brum, Lisete C Michelini
Heart Failure (HF), a common end point for many cardiovascular diseases, is a syndrome with a very poor prognosis. Although clinical trials in HF have achieved important outcomes in reducing mortality, little is known about functional mechanisms conditioning health improvement in HF patients. In parallel with clinical studies, basic science has been providing important discoveries to understand the mechanisms underlying the pathophysiology of HF, as well as to identify potential targets for the treatment of this syndrome...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28993402/exercise-intolerance-in-hfpef-diagnosing-and-ranking-its-causes-using-personalized-o2-pathway-analysis
#16
Nicholas E Houstis, Aaron S Eisman, Paul P Pappagianopoulos, Luke Wooster, Cole S Bailey, Peter D Wagner, Gregory D Lewis
Background -Heart failure with preserved ejection fraction (HFpEF) is a common syndrome with a pressing shortage of therapies. Exercise intolerance is a cardinal symptom of HFpEF, yet its pathophysiology remains uncertain. Methods -We investigated the mechanism of exercise intolerance in each of 134 patients referred for cardiopulmonary exercise testing (CPET): 79 with HFpEF and 55 controls. We performed CPET with invasive monitoring to measure hemodynamics, blood gases, and gas exchange during exercise. We used these measurements to quantify 6 steps of oxygen transport and utilization (the "O2 pathway") in each HFpEF patient, identifying the defective steps that impair each one's exercise capacity (peak VO2)...
October 9, 2017: Circulation
https://www.readbyqxmd.com/read/28993117/getting-to-the-heart-of-the-matter-what-is-the-landscape-of-exercise-rehabilitation-for-people-with-heart-failure-in-australia
#17
Simon Miller, Allison Mandrusiak, Julie Adsett
BACKGROUND: The benefits of exercise rehabilitation for people with heart failure (HF) are well established. In Australia, little is known about how the guidelines around exercise rehabilitation for people with HF are being implemented in clinical practice. Furthermore, it is unknown what organisational barriers are faced in providing exercise rehabilitation programs for this population. The aim of this study is to provide an updated review of exercise rehabilitation services for people with HF in Australia and to identify perceived organisational barriers to providing these services...
September 25, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28990152/therapeutic-targets-for-the-multi-system-pathophysiology-of-heart-failure-exercise-training
#18
REVIEW
Erik H Van Iterson, Thomas P Olson
Adult chronic heart failure (HF) is a terminal syndrome. While the HF phenotype is inhomogeneous across the ejection fraction spectrum, exercise intolerance remains a cardinal feature of all HF patients. Impairment of a single organ system cannot independently account for exercise intolerance in HF. Thus, the multi-system integrative pathophysiology of HF leads to challenges in identifying an effective medical therapy aimed at targeting a single mechanism to improve exercise tolerance. This unresolved medical care approach raises a number of points for discussion in this field as it is well-recognized that exercise intolerance is accompanied by increased hospitalizations and mortality across the HF spectrum...
October 9, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28987235/effects-of-l-arginine-supplementation-associated-with-continuous-or-interval-aerobic-training-on-chronic-heart-failure-rats
#19
Giovanna Tedesco Barcelos, Douglas Dalcin Rossato, Júlia Luiza Perini, Lucas Pereira Pinheiro, Carol Carvalho, Rodrigo Boemo Jaenisch, Cláudia Ramos Rhoden, Pedro Dal Lago, Ramiro Barcos Nunes
OBJECTIVE: Chronic heart failure (CHF) is related with exercise intolerance and impaired nitric oxide (NO) production, which can lead to several functional capacity alterations. Considering the possible superiority of aerobic interval training compared to continuous training and the capacity of l-arginine to restore the NO pathway, the aim of the present study was to investigate whether these treatments are beneficial to exercise capacity, muscle mass preservation and hemodynamic, inflammatory and oxidative stress parameters in CHF rats...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28977060/minute-ventilation-variability-during-cardiopulmonary-exercise-test-is-higher-in-sedentary-men-than-in-athletes
#20
Renata Rodrigues Teixeira de Castro, Sabrina Pedrosa Lima, Allan Robson Kluser Sales, Antonio Claudio Lucas da Nóbrega
BACKGROUND: The occurrence of minute-ventilation oscillations during exercise, named periodic breathing, exhibits important prognostic information in heart failure. Considering that exercise training could influence the fluctuation of ventilatory components during exercise, we hypothesized that ventilatory variability during exercise would be greater in sedentary men than athletes. OBJECTIVE: To compare time-domain variability of ventilatory components of sedentary healthy men and athletes during a progressive maximal exercise test, evaluating their relationship to other variables usually obtained during a cardiopulmonary exercise test...
September 2017: Arquivos Brasileiros de Cardiologia
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