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Thyrotropin diabetes

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https://www.readbyqxmd.com/read/29388360/beneficial-effects-of-thyroid-hormone-on-adipose-inflammation-and-insulin-sensitivity-of-obese-wistar-rats
#1
Ana C Panveloski-Costa, Caroline Serrano-Nascimento, Paula Bargi-Souza, Leonice L Poyares, Gabriela de S Viana, Maria T Nunes
Thyroid hormones play an important role in glucose metabolism and there is evidence of increased prevalence of thyroid dysfunction in obese and diabetic patients. This study aimed at evaluating the thyroid function and the effects of the triiodothyronine (T3) treatment on glycemia control, insulin sensitivity and subclinical inflammation in cafeteria-diet-induced obesity in rats. Obesity was induced in male Wistar rats by offering a cafeteria diet and a subset of the obese rats was treated with T3 (1.5 μg per 100 g of body weight) for a 28-day period...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29296189/metformin-affects-thyroid-function-in-male-rats
#2
Xiaowen Hu, Yang Liu, Changmei Wang, Lulu Hou, Xiaoyan Zheng, Yeqiu Xu, Lin Ding, Shuguang Pang
An intriguing area of research in type 2 diabetes recently discovered association of metformin therapy with thyroid functional and morphological changes. We aimed to evaluate the external symptoms and biochemical indicators concerning thyroid function in rats treated with metformin. Male wistar rats were randomly divided into four groups: Group (D-/M-), Group (D-/M+), Group (D+/M-), and Group (D+/M+), according to whether they were induced to diabetic model or placed on metformin. Characteristics of food intake, body weight, and other external symptoms were recorded...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29251783/effect-of-metformin-on-hypothalamic-pituitary-thyroid-axis-activity-in-elderly-antipsychotic-treated-women-with-type-2-diabetes-and-subclinical-hypothyroidism-a-preliminary-study
#3
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Metformin was found to reduce elevated serum thyrotropin levels, and this effect was partially determined by endogenous dopaminergic tone. The aim of this study was to compare the effect of metformin treatment on hypothalamic-pituitary-thyroid axis activity in elderly women with subclinical hypothyroidism treated with antipsychotic agents and not receiving this drug. The study population consisted of 34 elderly women with subclinical hypothyroidism, 16 of whom received antipsychotic drugs. Because of coexistent type 2 diabetes, these women were treated with metformin (2...
December 18, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29184811/dermatologic-manifestations-of-endocrine-disorders
#4
REVIEW
Michael Lause, Alisha Kamboj, Esteban Fernandez Faith
The skin serves as a window for clinicians to understand, diagnose, and monitor endocrine disease. Dermatologic manifestations of endocrinopathies contribute significantly to an individual's health and quality of life. In this review, we outline various disorders of the hypothalamic-pituitary axis, thyroid gland, pancreas, adrenal gland, and androgen axis as well as hereditary endocrine syndromes. In acromegaly, glycosaminoglycan deposition contributes to a thickening of skin and soft tissue, which manifests as coarsening and enlargement of facial and acral structures...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29179759/metabolic-syndrome-diabetes-and-inadequate-lifestyle-in-first-degree-relatives-of-acute-myocardial-infarction-survivors-younger-than-45%C3%A2-years-old
#5
Maria Helane C Gurgel, Renan M Montenegro Junior, Clarisse M Melo Ponte, Tamara Cristina S Sousa, Paulo Goberlanio B Silva, Lucia de Sousa Belém, Frederico Luis Braz Furtado, Lívia A de Araújo Batista, Alexandre C Pereira, Raul D Santos
BACKGROUND: A premature myocardial infarction (PMI) is usually associated with a familial component. This study evaluated cardiovascular risk factors in first-degree relatives (FDR) of patients with PMI not presenting the familial hypercholesterolemia phenotype. METHODS: A cross-sectional study comprising FDR of non-familial hypercholesterolemia patients who suffered a myocardial infarction <45-years age matched for age and sex with individuals without family history of cardiovascular disease...
November 28, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29169197/sex-dependent-effect-of-metformin-on-serum-prolactin-levels-in-hyperprolactinemic-patients-with-type-2-diabetes-a-pilot-study
#6
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Background Metformin was found to reduce circulating levels of pituitary hormones. Objective The purpose of this study was to assess whether sex determines the effect of metformin on lactotroph secretory function. Methods The study population included 25 women and 12 men with mildly elevated serum prolactin levels (25-75 ng/mL). Because of concomitant type 2 diabetes, all participants were treated with metformin (3 g daily). Plasma levels of glucose and lipids, HOMA1-IR, serum levels of prolactin, thyrotropin and free thyroid hormones, as well as Jostel's, SPINA-GT and SPINA-GD indices were assessed at baseline and at the end of metformin treatment...
November 23, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29102271/prevalence-of-malnutrition-inflammation-complex-syndrome-and-its-correlation-with-thyroid-hormones-in-chronic-haemodialysis-patients
#7
Venice Chávez Valencia, Oliva Mejía Rodríguez, Martha Eva Viveros Sandoval, Juan Abraham Bermúdez, Sergio Gutiérrez Castellanos, Citlalli Orizaga de la Cruz, Martha Alicia Roa Córdova
INTRODUCTION: Low levels of thyroid hormones, total triiodothyronine (T3) and free triiodothyronine (FT3) in haemodialysis patients is a marker of malnutrition and inflammation and are predictors of mortality. The aim of this study was to determine the prevalence of malnutrition-inflammation complex syndrome in haemodialysis and its relationship with the thyroid hormones thyrotropin, T3, FT3 and free thyroxine (FT4), as well as to evaluate the prevalence of low FT3 syndrome and its correlation with nutritional and inflammatory markers...
October 25, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28972979/thyroid-dysfunction-in-patients-with-impaired-glucose-metabolism-11-year-follow-up-from-the-tehran-thyroid-study
#8
M Gholampour Dehaki, A Amouzegar, H Delshad, Y Mehrabi, M Tohidi, F Azizi
OBJECTIVES: This study aimed to assess the prevalence and incidence and predictive factors of thyroid disorders (TD) in patients with impaired glucose metabolism. METHODS: Prevalence of TD was calculated in patients with impaired glucose metabolism compared to healthy controls, aged over 30 years in phase 1 of the Tehran Thyroid Study (TTS). Follow up assessments were conducted every 3 yrs, after which incidence of TD was calculated and its correlations with age, sex, smoking, blood pressure, body mass index (BMI), thyroid peroxidase antibody (TPOAb), thyrotropin (TSH), insulin resistance index, triglycerides and cholesterol were assessed...
2017: PloS One
https://www.readbyqxmd.com/read/28845039/preoperative-and-postoperative-pituitary-function-in-patients-with-tuberculum-sellae-meningioma-based-on-pituitary-provocation-tests
#9
Shingo Fujio, Hirofumi Hirano, Mami Yamashita, Satoshi Usui, Yasuyuki Kinoshita, Atsushi Tominaga, Tomoko Hanada, Hitoshi Yamahata, Hiroshi Tokimura, Ryosuke Hanaya, Kaoru Kurisu, Kazunori Arita
Given the anatomical proximity of tuberculum sellae meningioma (TSM) to the hypothalamo-pituitary system, pituitary function impairments are of great concern. We retrospectively investigated pituitary function changes following surgery in patients with TSM using pituitary provocation tests (PPTs). Thirty-one patients (27 females and 4 males) with TSM underwent initial transcranial surgery (29 patients) or transsphenoidal surgery (two patients); surgeries were performed carefully to avoid injuring the pituitary stalk...
October 15, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28556290/moderate-to-high-normal-levels-of-thyrotropin-is-a-risk-factor-for-urinary-incontinence-and-an-unsuitable-quality-of-life-in-women-over-65-years
#10
Estela Cuevas-Romero, Angélica Sánchez-Cardiel, Angélica M Zamora-Gallegos, Rosalía Cruz-Lumbreras, Dora L Quintanilla, Francisco Castelán, Margarita Martínez-Gómez
The present study was aimed to investigate the relationship between normal serum concentrations of thyrotropin (TSH) and urinary incontinence (IU), urinary infections, and quality of life in old women. Euthyroid post-menopausal women without sarcopenia, estrogen replacement, emotional illness, and-or cancer were enrolled as participants. Anthropometric indicators, serum glucose and estradiol, and thyroid profile were measured. Sociodemographic, clinical, physical activity, and quality of life (SF-36) surveys were applied...
May 28, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28545910/thyroid-function-test-in-diabetic-ketoacidosis
#11
Amir Ahmad Mirboluk, Farzaneh Rohani, Ramin Asadi, Mohammad Reza Eslamian
BACKGROUND: Metabolism of thyroid hormones is influenced by acute systemic illnesses including diabetic ketoacidosis. In these cases T3 level is usually decreased and this condition is called "low T3 syndrome" which is usually reversed by treating the under lying Disease. OBJECTIVES: thyroid function test analysis before and after diabetic ketoacidosis treatment. METHOD: In this cross sectional study thyroid function tests were analyzed in 16 diabetic ketoacidosis patients according to American diabetic association before and after insulin therapy...
April 15, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28407664/fenugreek-a-potent-hypoglycaemic-herb-can-cause-central-hypothyroidism-via-leptin-a-threat-to-diabetes-phytotherapy
#12
Jayjeet Majumdar, Pratip Chakraborty, Analava Mitra, Nirmal Kumar Sarkar, Supriti Sarkar
Fenugreek (Trigonella foenum graecum), a medicinal herb with potent antihyperglycaemic and hypoglycaemic effects, is used to treat diabetes. This study is aimed to explore the interaction of fenugreek seed extract (FSE) and HPT (hypothalamic-pituitary-thyroid) axis in context of leptin secretion which have important role in normal and type-1 diabetic subjects. FSE (confirmed to contain trigonelline, diosgenin, 4 hydroxyisoleucine) was gavaged (0.25 gm/kg body weight/day) to normal and alloxan-induced type-1 diabetic rats for 4 weeks...
July 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28345646/association-of-high-normal-hba1c-and-tsh-levels-with-the-risk-of-chd-a-10-year-cohort-study-and-svm-analysis
#13
Hui Li, Ying Cui, Yanan Zhu, Haiying Yan, Wenge Xu
This study aimed to determine the association between the clinical reference range of serum glycated hemoglobin A1c (HbA1c) and thyrotropin (TSH) and the risk of coronary heart disease (CHD) in non-diabetic and euthyroid patients. We examined baseline HbA1c and TSH in 538 healthy participants, and then analyzed the associations and potential value of these indicators for predicting CHD using Cox proportional hazard and support vector machine analyses. During the median follow-up of 120 months, 39 participants later developed CHD...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034692/vitamin-d-and-thyrotropin-in-type-2-diabetic-patients
#14
José María Calvo-Romero, José Manuel Ramiro-Lozano
Vitamin D status and thyroid function may be related. Using our data from two previous studies in type 2 diabetic patients, we found slightly higher serum thyrotropin levels in patients with vitamin D deficiency (at the limit of statistical significance) and no effect of correction of vitamin D deficiency in serum thyrotropin levels.
October 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27917035/polyglandular-autoimmune-syndrome-in-pregnancy-case-report
#15
Basilio Pecorino, Maria Cristina Teodoro, Paolo Scollo
Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D., 34-year-old woman (gravida 2 para 1), was referred to the High Risk Pregnancy Outpatient Clinic at Cannizzaro Hospital in Catania at 8 weeks' gestation. She was affected from type III Polyglandular Autoimmune Disease (Type 1 Diabetes Mellitus, Autoimmune Hashimoto Thyroiditis and Celiac Disease)...
September 2016: Italian Journal of Gynaecology & Obstetrics: Official Publication of the Societa Italiana di Ginecologia e Ostetricia (SIGO)
https://www.readbyqxmd.com/read/27775795/helicobacter-pylori-caga-antibodies-and-thyroid-function-in-latent-autoimmune-diabetes-in-adults
#16
A P Delitala, G M Pes, A Errigo, M Maioli, G Delitala, M P Dore
OBJECTIVE: H. pylori infection is reportedly associated with autoimmune diseases such as chronic thyroiditis and autoimmune diabetes. The aim of this study is to determine the association between H. pylori infection and its virulent strain CagA with antibodies against thyroperoxidase (TPO Ab) and thyrotropin (TSH) in a cohort of latent autoimmune diabetes in adult (LADA) patients. PATIENTS AND METHODS: We included 234 LADA patients (53.8% women). Antibodies against H...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27588386/sex-dependent-effect-of-metformin-on-hypothalamic-pituitary-thyroid-axis-activity-in-patients-with-subclinical-hypothyroidism
#17
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Metformin was found to reduce elevated serum thyrotropin levels. No previous study has compared the effect of this drug on serum levels of thyrotropin and thyroid hormones between men and women. METHODS: The study included 23 women and 12 men with subclinical hypothyroidism, who because of coexisting diabetes or impaired fasting glucose were treated with metformin (1.7-3.0g daily). Fasting plasma glucose levels, the homeostatic model assessment 1 of insulin resistance ratio (HOMA1-IR), glycated hemoglobin, serum levels of thyrotropin, free and total thyroid hormones and prolactin, as well as thyroid peroxidase and thyroglobulin antibodies were assessed at baseline and after 4 months of metformin treatment...
December 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27386163/liver-x-receptor-%C3%AE-new-player-in-the-regulatory-network-of-thyroid-hormone-and-browning-of-white-fat
#18
Yifei Miao, Margaret Warner, Jan-Ke Gustafsson
The recent discovery of browning of white adipose tissue (WAT) has raised great research interest because of its significant potential in counteracting obesity and type II diabetes. However, the mechanisms underlying browning are still poorly understood. Liver X receptors (LXRs) are one class of nuclear receptors, which play a vital role in regulating cholesterol, triglyceride and glucose metabolism. Following our previous finding that LXRs serve as repressors of UCP1 in classic brown adipose tissue in female mice, we found that LXRs, especially LXRβ, also repress the browning process of subcutaneous adipose tissue (SAT) in male rodents fed a normal diet...
April 2016: Adipocyte
https://www.readbyqxmd.com/read/27315814/inositol-s-in-thyroid-function-growth-and-autoimmunity
#19
REVIEW
Salvatore Benvenga, Alessandro Antonelli
Myo-inositol and phosphatidylinositol(s) play a pivotal function in many metabolic pathways that, if impaired, impact unfavorably on human health. This review analyzes several experimental and clinical investigations regarding the involvement of this class of molecules in physiological and pathological situations, with a major focus on thyroid. Central issues are the relationship between phosphatidylinositol and thyrotropin (TSH) signaling on one hand, and phosphatydylinositol and autoimmunity on the other hand...
December 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27083162/igf-i-levels-reflect-hypopituitarism-severity-in-adults-with-pituitary-dysfunction
#20
Amit Tirosh, Yoel Toledano, Hiba Masri-Iraqi, Yoav Eizenberg, Gloria Tzvetov, Dania Hirsch, Carlos Benbassat, Eyal Robenshtok, Ilan Shimon
PURPOSE: To evaluate the utility of Insulin-like growth factor I (IGF-I) standard deviation score (SDS) as a surrogate marker of severity of hypopituitarism in adults with pituitary pathology. METHODS: We performed a retrospective data analysis, including 269 consecutive patients with pituitary disease attending a tertiary endocrine clinic in 1990-2015. The medical files were reviewed for the complete pituitary hormone profile, including IGF-I, and clinical data...
August 2016: Pituitary
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