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Thyrotropin diabetes

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https://www.readbyqxmd.com/read/28407664/fenugreek-a-potent-hypoglycaemic-herb-can-cause-central-hypothyroidism-via-leptin-a-threat-to-diabetes-phytotherapy
#1
Jayjeet Majumdar, Pratip Chakraborty, Analava Mitra, Nirmal Kumar Sarkar, Supriti Sarkar
Fenugreek (Trigonella foenum graecum), a medicinal herb with potent antihyperglycaemic and hypoglycaemic effects, is used to treat diabetes. This study is aimed to explore the interaction of fenugreek seed extract (FSE) and HPT (hypothalamic-pituitary-thyroid) axis in context of leptin secretion which have important role in normal and type-1 diabetic subjects. FSE (confirmed to contain trigonelline, diosgenin, 4 hydroxyisoleucine) was gavaged (0.25 gm/kg body weight/day) to normal and alloxan-induced type-1 diabetic rats for 4 weeks...
April 13, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28345646/association-of-high-normal-hba1c-and-tsh-levels-with-the-risk-of-chd-a-10-year-cohort-study-and-svm-analysis
#2
Hui Li, Ying Cui, Yanan Zhu, Haiying Yan, Wenge Xu
This study aimed to determine the association between the clinical reference range of serum glycated hemoglobin A1c (HbA1c) and thyrotropin (TSH) and the risk of coronary heart disease (CHD) in non-diabetic and euthyroid patients. We examined baseline HbA1c and TSH in 538 healthy participants, and then analyzed the associations and potential value of these indicators for predicting CHD using Cox proportional hazard and support vector machine analyses. During the median follow-up of 120 months, 39 participants later developed CHD...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28034692/vitamin-d-and-thyrotropin-in-type-2-diabetic-patients
#3
José María Calvo-Romero, José Manuel Ramiro-Lozano
Vitamin D status and thyroid function may be related. Using our data from two previous studies in type 2 diabetic patients, we found slightly higher serum thyrotropin levels in patients with vitamin D deficiency (at the limit of statistical significance) and no effect of correction of vitamin D deficiency in serum thyrotropin levels.
December 13, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27917035/polyglandular-autoimmune-syndrome-in-pregnancy-case-report
#4
Basilio Pecorino, Maria Cristina Teodoro, Paolo Scollo
Type III Polyglandular Autoimmune Syndrome is a multiple endocrine disorders disease determined by autoimmunity; it can be diagnosed if a patient is affected by Type 1 Diabetes Mellitus and another autoimmune disease, except Addison Disease, for example Autoimmune Hashimoto Thyroiditis or Celiac Disease. R.D., 34-year-old woman (gravida 2 para 1), was referred to the High Risk Pregnancy Outpatient Clinic at Cannizzaro Hospital in Catania at 8 weeks' gestation. She was affected from type III Polyglandular Autoimmune Disease (Type 1 Diabetes Mellitus, Autoimmune Hashimoto Thyroiditis and Celiac Disease)...
September 2016: Italian Journal of Gynaecology & Obstetrics: Official Publication of the Societa Italiana di Ginecologia e Ostetricia (SIGO)
https://www.readbyqxmd.com/read/27775795/helicobacter-pylori-caga-antibodies-and-thyroid-function-in-latent-autoimmune-diabetes-in-adults
#5
A P Delitala, G M Pes, A Errigo, M Maioli, G Delitala, M P Dore
OBJECTIVE: H. pylori infection is reportedly associated with autoimmune diseases such as chronic thyroiditis and autoimmune diabetes. The aim of this study is to determine the association between H. pylori infection and its virulent strain CagA with antibodies against thyroperoxidase (TPO Ab) and thyrotropin (TSH) in a cohort of latent autoimmune diabetes in adult (LADA) patients. PATIENTS AND METHODS: We included 234 LADA patients (53.8% women). Antibodies against H...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27588386/sex-dependent-effect-of-metformin-on-hypothalamic-pituitary-thyroid-axis-activity-in-patients-with-subclinical-hypothyroidism
#6
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Metformin was found to reduce elevated serum thyrotropin levels. No previous study has compared the effect of this drug on serum levels of thyrotropin and thyroid hormones between men and women. METHODS: The study included 23 women and 12 men with subclinical hypothyroidism, who because of coexisting diabetes or impaired fasting glucose were treated with metformin (1.7-3.0g daily). Fasting plasma glucose levels, the homeostatic model assessment 1 of insulin resistance ratio (HOMA1-IR), glycated hemoglobin, serum levels of thyrotropin, free and total thyroid hormones and prolactin, as well as thyroid peroxidase and thyroglobulin antibodies were assessed at baseline and after 4 months of metformin treatment...
December 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27386163/liver-x-receptor-%C3%AE-new-player-in-the-regulatory-network-of-thyroid-hormone-and-browning-of-white-fat
#7
Yifei Miao, Margaret Warner, Jan-Ke Gustafsson
The recent discovery of browning of white adipose tissue (WAT) has raised great research interest because of its significant potential in counteracting obesity and type II diabetes. However, the mechanisms underlying browning are still poorly understood. Liver X receptors (LXRs) are one class of nuclear receptors, which play a vital role in regulating cholesterol, triglyceride and glucose metabolism. Following our previous finding that LXRs serve as repressors of UCP1 in classic brown adipose tissue in female mice, we found that LXRs, especially LXRβ, also repress the browning process of subcutaneous adipose tissue (SAT) in male rodents fed a normal diet...
April 2016: Adipocyte
https://www.readbyqxmd.com/read/27315814/inositol-s-in-thyroid-function-growth-and-autoimmunity
#8
REVIEW
Salvatore Benvenga, Alessandro Antonelli
Myo-inositol and phosphatidylinositol(s) play a pivotal function in many metabolic pathways that, if impaired, impact unfavorably on human health. This review analyzes several experimental and clinical investigations regarding the involvement of this class of molecules in physiological and pathological situations, with a major focus on thyroid. Central issues are the relationship between phosphatidylinositol and thyrotropin (TSH) signaling on one hand, and phosphatydylinositol and autoimmunity on the other hand...
December 2016: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/27083162/igf-i-levels-reflect-hypopituitarism-severity-in-adults-with-pituitary-dysfunction
#9
Amit Tirosh, Yoel Toledano, Hiba Masri-Iraqi, Yoav Eizenberg, Gloria Tzvetov, Dania Hirsch, Carlos Benbassat, Eyal Robenshtok, Ilan Shimon
PURPOSE: To evaluate the utility of Insulin-like growth factor I (IGF-I) standard deviation score (SDS) as a surrogate marker of severity of hypopituitarism in adults with pituitary pathology. METHODS: We performed a retrospective data analysis, including 269 consecutive patients with pituitary disease attending a tertiary endocrine clinic in 1990-2015. The medical files were reviewed for the complete pituitary hormone profile, including IGF-I, and clinical data...
August 2016: Pituitary
https://www.readbyqxmd.com/read/26922558/the-effect-of-metformin-on-the-hypothalamic-pituitary-thyroid-axis-in-patients-with-type-2-diabetes-and-amiodarone-induced-hypothyroidism
#10
Robert Krysiak, Małgorzata Gilowska, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Chronic metformin treatment was found to reduce elevated thyrotropin levels. Amiodarone treatment is associated with a range of effects in thyroid function from mild derangements to overt thyroid dysfunction. No previous study has investigated the effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with amiodarone-induced hypothyroidism. METHODS: The study included three age-, sex- and weight-matched groups of amiodarone-treated patients with type 2 diabetes: patients with treated overt hypothyroidism (group I, n=15), patients with untreated subclinical hypothyroidism (group II, n=15), and subjects without thyroid disorders (group III, n=18)...
April 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/26910563/free-thyroxine-during-early-pregnancy-and-risk-for-gestational-diabetes
#11
MULTICENTER STUDY
James E Haddow, Wendy Y Craig, Louis M Neveux, Glenn E Palomaki, Geralyn Lambert-Messerlian, Fergal D Malone, Mary E D'Alton
Several studies have now reported associations between gestational diabetes mellitus (GDM) and low free thyroxine (fT4) during the second and third trimesters, but not in the first trimester. The present study further examines relationships between low fT4, maternal weight, and GDM among women in the FaSTER (First and Second Trimester Evaluation of Risk) trial, in an effort to determine the extent to which thyroid hormones might contribute to causality. The FaSTER cohort includes 9351 singleton, euthyroid women; 272 of these women were subsequently classified as having GDM...
2016: PloS One
https://www.readbyqxmd.com/read/26895275/the-effect-of-metformin-on-hypothalamic-pituitary-thyroid-axis-activity-in-women-with-interferon-induced-hypothyroidism-a-pilot-study
#12
R Krysiak, W Szkrobka, B Okopien
BACKGROUND: One of the most frequent adverse effects of interferon-α therapy is thyroiditis. Metformin was found to improve insulin sensitivity in hepatitis C patients, as well as to reduce elevated thyrotropin levels in patients with hypothyroidism. The aim of this study was to investigate the effect of metformin on hypothalamic-pituitary-thyroid axis activity in patients with interferon-induced thyroiditis. METHODS: The study included 2 matched groups of women with type 2 diabetes and untreated subclinical hypothyroidism: patients with interferon-induced thyroiditis (n=8) and patients with Hashimoto's thyroiditis (n=12)...
February 2016: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/26870137/etiological-and-clinical-characteristics-of-central-diabetes-insipidus-in-children-a-single-center-experience
#13
Janel D Hunter, Ali S Calikoglu
BACKGROUND: Central diabetes insipidus (CDI) results from a number of conditions affecting the hypothalamic-neurohypophyseal system to cause vasopressin deficiency. Diagnosis of CDI is challenging, and clinical data and guidelines for management are lacking. We aim to characterize clinical and radiological characteristics of a cohort of pediatric patients with CDI. METHODS: A chart review of 35 patients with CDI followed at North Carolina Children's Hospital from 2000 to 2015 was undertaken...
2016: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/26858210/the-effect-of-metformin-on-prolactin-levels-in-patients-with-drug-induced-hyperprolactinemia
#14
Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien
BACKGROUND: In bromocriptine-treated hyperprolactinemic patients with impaired glucose tolerance, metformin was found to reduce plasma levels of prolactin. No previous study has investigated its impact on plasma prolactin in patients with drug-induced hyperprolactinemia. METHODS: The study included 20 women with antipsychotic-induced hyperprolactinemia and 12 normoprolactinemic women, who, because of coexisting glucose metabolism abnormalities, were treated for 6months with metformin...
May 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26842591/reference-intervals-of-thyroid-hormones-in-a-previously-iodine-deficient-but-presently-more-than-adequate-area-of-western-china-a-population-based-survey
#15
Jing Cai, Yujie Fang, Da Jing, Shaoyong Xu, Jie Ming, Bin Gao, Han Shen, Rong Zhang, Qiuhe Ji
The aim of our study is to establish the reference intervals (RIs) of thyroid hormones in a previously iodine-deficient area but presently more than iodine-adequate area of Western China, and also to investigate the factors which affect thyroid function. The cross-sectional study conducted in Xi'an, was based on 2007-2008 China National Diabetes and Metabolic Disorders Survey. Among 1286 participating adults, 717 were finally included as reference population. Thyrotropin (TSH), total triiodothyronine (T3), free triiodothyronine (FT3), total thyroxine (T4), free thyroxine (FT4), thyroperoxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) were measured...
April 25, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/26675390/-effect-of-the-treatment-acceptance-on-the-perinatal-outcomes-in-women-with-subclinical-hypothyroidism-positive-thyroid-gland-peroxidase-antibody-in-early-pregnancy
#16
Junjuan Yang, Huafeng Guo, Shugui Ding, Beibei Tao, Xinhua Zhang
OBJECTIVE: To investigate if women with subclinical hypothyroidism (SCH), positive thyroid gland peroxidase antibody (TPOAb) in early pregnancy accepted treatment or not had effect on perinatal outcomes. METHODS: 15 000 pregnant women who delivered in Women and Infants Hospital of Zhengzhou from January 1, 2013 to June 30, 2014 were recruited retrospectively. Among them, 2 042 women had SCH in early pregnancy. The diagnostic standard of SCH was serum free thyroxine (FT4) between 12...
September 2015: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/26615224/no-evidence-of-association-between-subclinical-thyroid-disorders-and-common-carotid-intima-medial-thickness-or-atherosclerotic-plaque
#17
COMPARATIVE STUDY
A P Delitala, F Filigheddu, M Orrù, M AlGhatrif, M Steri, M G Pilia, A Scuteri, M Lobina, M G Piras, G Delitala, E G Lakatta, D Schlessinger, F Cucca
BACKGROUND AND AIMS: Increased carotid artery intima-media thickness (IMT) and the presence of plaques have been shown to be predictors of cardiovascular disease. The cardiovascular risk in patients with overt thyroid diseases is related to increased risk of atherosclerosis, but there has been no clear evidence about subclinical disorders. We have assessed whether subclinical thyroid dysfunction is associated with arterial thickening and plaque. METHODS AND RESULTS: The SardiNIA study is a population-based survey on the Italian island of Sardinia...
December 2015: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/26586839/maternal-hypothyroxinaemia-in-pregnancy-is-associated-with-obesity-and-adverse-maternal-metabolic-parameters
#18
Bridget A Knight, Beverley M Shields, Andrew T Hattersley, Bijay Vaidya
OBJECTIVE: Subclinical hypothyroidism and isolated hypothyroxinaemia in pregnancy have been associated with an increased risk of gestational diabetes. We aimed to ascertain if these women have a worse metabolic phenotype than euthyroid pregnant women. DESIGN, SUBJECTS AND METHODS: We recruited 956 healthy Caucasian women with singleton, non-diabetic pregnancies from routine antenatal clinics. Detailed anthropometric measurements (including BMI and skinfold thickness) and fasting blood samples (for TSH, free thyroxine (FT4), free triiodothyronine (FT3), HbA1c, lipid profile, plasma glucose and insulin resistance (HOMA-IR) analysis) were obtained at 28 weeks gestation...
January 2016: European Journal of Endocrinology
https://www.readbyqxmd.com/read/26504234/liver-x-receptor-%C3%AE-controls-thyroid-hormone-feedback-in-the-brain-and-regulates-browning-of-subcutaneous-white-adipose-tissue
#19
Yifei Miao, Wanfu Wu, Yubing Dai, Laure Maneix, Bo Huang, Margaret Warner, Jan-Åke Gustafsson
The recent discovery of browning of white adipose tissue (WAT) has raised great research interest because of its significant potential in counteracting obesity and type 2 diabetes. Browning is the result of the induction in WAT of a newly discovered type of adipocyte, the beige cell. When mice are exposed to cold or several kinds of hormones or treatments with chemicals, specific depots of WAT undergo a browning process, characterized by highly activated mitochondria and increased heat production and energy expenditure...
November 10, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/26421666/effects-of-thyroid-hormone-replacement-on-glycated-hemoglobin-levels-in-non-diabetic-subjects-with-overt-hypothyroidism
#20
Sailaja Anantarapu, Suresh Vaikkakara, Alok Sachan, Bobbidi Venkata Phaneendra, Mustur Manohar Suchitra, Amaresh Ponnala Reddy, Sunil Epuri, Arun Mukka, Dharaneswari Vemvakam
OBJECTIVE: Glycated hemoglobin (HbA1c) may not accurately reflect the level of glycemia in conditions of altered erythrocyte turnover. Hypothyroidism is one condition associated with sluggish erythropoesis. To assess changes in HbA1c, independent of changes in plasma glucose after initiation of thyroxine replacement in patients with overt hypothyroidism. MATERIALS AND METHODS: In this prospective longitudinal study carried out in a tertiary care centre, adult non-diabetic patients with overt hypothyroidism recruited between March 2012 to August 2013 were rendered euthyroid on thyroxine...
December 2015: Archives of Endocrinology and Metabolism
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