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https://www.readbyqxmd.com/read/27871293/genetic-and-epigenetic-alterations-in-the-gnas-locus-and-clinical-consequences-in-pseudohypoparathyroidism-italian-common-healthcare-pathways-adoption
#1
L de Sanctis, F Giachero, G Mantovani, G Weber, M Salerno, G I Baroncelli, M F Elli, P Matarazzo, M Wasniewska, L Mazzanti, G Scirè, D Tessaris
BACKGROUND: Genetic and epigenetic alterations in the GNAS locus are responsible for the Gsα protein dysfunctions causing Pseudohypoparathyroidism (PHP) type Ia/c and Ib, respectively. For these heterogeneous diseases characterized by multiple hormone resistances and Albright's Hereditary Osteodystrophy (AHO) the current classification results inadequate because of the clinical overlap between molecular subtypes and a standard clinical approach is still missing. In the present paper several members of the Study Group Endocrine diseases due to altered function of Gsα protein of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED) have reviewed and updated the clinical-molecular data of the largest case series of (epi)/genetically characterized AHO/PHP patients; they then produced a common healthcare pathway for patients with these disorders...
November 21, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27790353/does-hypothyroidism-affect-post-operative-outcome-of-patients-undergoing-carpal-tunnel-release
#2
Sharareh Roshanzamir, Sahameddin Mortazavi, Alireza Dabbaghmanesh
INTRODUCTION: Risk factors associated with Carpal Tunnel Syndrome include repetitive use of hand and wrist, advanced age, obesity, pregnancy, diabetes mellitus and thyroid disease. Decompression of the median nerve is the last treatment of choice usually indicated when negative results to conservative treatments remain for three months. In this study, we aimed to find out whether hypothyroid patients would respond to CTS surgical decompression differently in comparison to healthy individuals...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27760888/elevated-thyroid-stimulating-hormone-levels-are-associated-with-metabolic-syndrome-in-a-chinese-community-based-population-of-euthyroid-people-aged-40-years-and-older
#3
Xu Bojin, Yang Hui, Wang Zhixiao, Yang Tao, Guo Hongwei, Cheng Pei, He Wei, Sun Min, Chen Huanhuan, Duan Yu
This study investigated whether high-normal thyrotropin (TSH) levels are associated with metabolic syndrome in euthyroid Chinese people≥40 years old. Clinical and metabolic factors were assessed in 2,356 subjects (40-77 years old) with TSH levels in the normal range (0.35-5.00 mU/L). Using 2.50 mU/L as the cut-off point of TSH level within the normal range, we divided subjects into the high-TSH (2.50-5.00 mU/L; n=1,064) and low-TSH (0.35-2.50 mU/L; n=11,292) group. The results showed that the mean levels of body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), and fasting plasma glucose (FPG) were higher in the high-TSH group and TSH levels were significantly positively correlated with BMI, LDL-C, TC, and FPG...
June 17, 2016: Journal of Biomedical Research
https://www.readbyqxmd.com/read/27734684/-are-the-thyroid-hormones-and-thyrotropin-associated-with-cardiometabolic-risks-and-insulin-resistance-even-in-euthyroid-subjects
#4
Vojtěch Hainer, Hana Zamrazilová, Irena Aldhoon Hainerová
Associations of both hypothyroidism and subclinical hypothyroidism with metabolic syndrome are well established. Nowadays, more attention has been paid to the role of thyroid hormones and thyrotropin (TSH) within the euthyroid range on the development of cardiometabolic health risks. The paper summarizes current knowledge related to the associations of lower free thyroxine (fT4) level and higher levels of both free triiodothyronine (fT3) and TSH with body adiposity, metabolic syndrome and insulin resistance in euthyroid subjects...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27717596/inositol-as-putative-integrative-treatment-for-pcos
#5
Alessandro D Genazzani
Studies over the last decade have demonstrated that some polycystic ovary syndrome (PCOS) patients have abnormal insulin sensitivity (insulin resistance), independently from being overweight or obese. This induces the risk of developing type 2 diabetes in such PCOS patients. The use of insulin sensitizers (i.e. metformin), reduces such metabolic, and most hormonal, impairments. As metformin often induces side effects, new integrative strategies have been proposed to treat insulin resistance, such as the use of inositols...
September 16, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27672073/obstructive-sleep-apnea-syndrome-and-hypothyroidism-merely-concurrence-or-causal-association
#6
Wojciech Kuczyński, Agata Gabryelska, Łukasz Mokros, Piotr Białasiewicz
The prevalence of obstructive sleep apnea-hypopnea syndrome (OSAHS) ranges from 4 to 7% in men and from 2 to 5% in women. Its deleterious consequences such as traffic accidents, cardiovascular complications increasing morbidity and mortality, make it a major health problem. Apart from obesity (a major risk factor for OSAHS), hypothyroid patients are prone to reveal this phenotype. Although hypothyroidism seems an acknowledged risk factor for OSAHS, some authors report the lack of clinically relevant association...
2016: Pneumonologia i Alergologia Polska
https://www.readbyqxmd.com/read/27629733/evaluation-of-selected-atherosclerosis-risk-factors-in-women-with-subclinical-hypothyroidism-treated-with-l-thyroxine
#7
Maria Adamarczuk-Janczyszyn, Aleksandra Zdrojowy-Wełna, Natalia Rogala, Katarzyna Zatońska, Grażyna Bednarek-Tupikowska
BACKGROUND: Subclinical hypothyroidism (SCH) is a common endocrine disorder, probably increasing cardiovascular (CV) risk. However, the relation between SCH and atherosclerosis risk factors remains unclear. OBJECTIVES: The aim of the study was to evaluate selected atherosclerosis risk factors in women with SCH in comparison to a group of healthy women and women with overt hypothyroidism, as well as to investigate the influence of L-thyroxine replacement on those risk factors...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/27611730/subclinical-hypothyroidism-in-danish-lean-and-obese-children-and-adolescents
#8
Maria Dahl, Johanne Dam Ohrt, Cilius Esmann Fonvig, Julie Tonsgaard Kloppenborg, Oluf Pedersen, Torben Hansen, Jens Christian Holm
OBJECTIVE: Thyroid abnormalities are common in obese children. The aim of the present study was to examine the prevalence of subclinical hypothyroidism (SH) and to determine how circulating thyroid hormone concentrations correlate with anthropometrics in Danish lean and obese children and adolescents. METHODS: We included 3,006 children and adolescents, aged 6-18 years, from the Registry of the Danish Childhood Obesity Biobank in this cross-sectional study. The overweight/obese group (n=1,796) consisted of study participants with a body mass index (BMI) standard deviation score (SDS) ≥1...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27578194/the-influence-of-thyroid-function-inflammation-and-obesity-on-risk-prediction-of-acute-kidney-injury-by-cystatin-c-in-the-emergency-department
#9
Moritz Schanz, Dirk Pannes, Jürgen Dippon, Christoph Wasser, Mark Dominik Alscher, Martin Kimmel
BACKGROUND/AIMS: There is a growing role for emergency departments (ED) in assessing acute kidney injury (AKI) for hospital admissions but there are few studies addressing acute kidney injury biomarkers and confounding factors in the ED. Cystatin C (CysC), a newer renal biomarker, is influenced by thyroid function, inflammation and obesity. This study aims to be the first study to address the impact of these parameters in the ED. METHODS: Admitted patients (n=397) were enrolled in the ED at Robert-Bosch-Hospital, Stuttgart, Germany...
September 1, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27559364/the-impact-of-the-metabolic-phenotype-on-thyroid-function-in-obesity
#10
Paolo Marzullo, Chiara Mele, Stefania Mai, Gabriele Guzzaloni, Davide Soranna, Maria Antonella Tagliaferri, Maria Elisa Berselli, Flavia Prodam, Daniela Surico, Gianluca Aimaretti, Massimo Scacchi
BACKGROUND: Obesity is known to promote mild hyperthyrotropinaemia by unknown metabolic mechanisms. This investigation aimed to explore the association between thyroid function and metabolic phenotype in euthyroid obese individuals. Retrospective, cross-sectional study. Tertiary care center. METHODS: 952 euthyroid obese individuals referred to our Institution for obesity. Serum levels of TSH, FT4, glucose, insulin and HbA1c levels, lipid profile, liver function and proinflammatory indices were measured...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27558484/recombinant-human-thyrotropin-improves-endothelial-coronary-flow-reserve-in-thyroidectomized-patients-with-differentiated-thyroid-cancer
#11
Serena Ippolito, Renato Ippolito, Carmela Peirce, Roberta Esposito, Debora Arpaia, Ciro Santoro, Gilda Pontieri, Sara Cocozza, Maurizio Galderisi, Bernadette Biondi
BACKGROUND: The role of thyrotropin (TSH) on the cardiovascular system has been poorly investigated. It is unknown whether the changes in the vasculature associated with thyroid diseases result from altered thyroid hormone action or whether they are a consequence of a direct effect of TSH on endothelial cells. The present study was designed to evaluate the endothelial response of coronary flow to TSH in patients with differentiated thyroid cancer (DTC) without cardiovascular risk factors...
October 14, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27546362/serum-soluble-lectin-like-oxidized-low-density-lipoprotein-receptor-1-levels-in-patients-with-restless-legs-syndrome
#12
G Halac, E Kilic, M A Cikrikcioglu, K Celik, A Toprak-Erek, S Keskin, I Gultepe, R S Celik, N Ozaras, A Yildiz, S Aydin, O Akan, C Karatoprak, Y Sekin, T Asil
OBJECTIVE: The aim of this study was to assess the predisposition for atherosclerosis in patients with RLS through serum sLOX-1 (serum Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1) measurements. BACKGROUND: Recent epidemiological studies have suggested an association of RLS with certain chronic conditions such as diabetes mellitus (DM), obesity, hypertension (HT), and hyperlipidemia. LOX-1 is expressed in endothelial cells, macrophages, and in smooth muscle cells under the effect of proatherogenic conditions...
2016: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/27526420/there-is-no-difference-in-the-plasma-cortisol-level-between-women-with-body-mass-index-bmi-greater-than-or-equal-25-kg-m%C3%A2-and-polycystic-ovary-syndrome-and-the-control-group-without-polycystic-ovary-syndrome-and-bmi-25-kg-m%C3%A2
#13
Sandra Mrozińska, Tomasz Milewicz, Marta Kiałka, Katarzyna Gosztyła, Małgorzata Lurzyńska, Monika Kabzińska-Turek
A 4-8% of women of reproductive age suffer from the polycystic ovary syndrome (PCOS). The clinical and/ or biochemical hyperandrogenemia is found up to 75% of women with PCOS. It is unclear whether the hyperandogenemia in PCOS is caused directly by this disorder or by obesity. The recent studies have shown that the cortisol level in PCOS patients can be elevated, decreased or comparable to the control group. The aim of our study was to assess the cortisol plasma level in women with body mass index greater than or equal to 25 kg/ m², with and without PCOS...
2016: Przegla̧d Lekarski
https://www.readbyqxmd.com/read/27485208/pituitary-response-to-thyrotropin-releasing-hormone-in-children-with-overweight-and-obesity
#14
Jesse Rijks, Bas Penders, Elke Dorenbos, Saartje Straetemans, Willem-Jan Gerver, Anita Vreugdenhil
Thyroid stimulating hormone (TSH) concentrations in the high normal range are common in children with overweight and obesity, and associated with increased cardiovascular disease risk. Prior studies aiming at unravelling the mechanisms underlying these high TSH concentrations mainly focused on factors promoting thyrotropin releasing hormone (TRH) production as a cause for high TSH concentrations. However, it is unknown whether TSH release of the pituitary in response to TRH is affected in children with overweight and obesity...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27460601/sustained-zero-order-delivery-of-gc-1-from-a-nanochannel-membrane-device-alleviates-metabolic-syndrome
#15
C S Filgueira, E Nicolov, R L Hood, A Ballerini, J Garcia-Huidobro, J Z Lin, D Fraga, P Webb, O M Sabek, A O Gaber, K J Phillips, A Grattoni
BACKGROUND/OBJECTIVES: Our objective was to assess the sustained, low-dose and constant administration of the thyroid receptor beta (TRβ)-selective agonist GC-1 (sobetirome) from a novel nanochannel membrane device (NMD) for drug delivery. As it known to speed up metabolism, accomplish weight loss, improve cholesterol levels, and possess anti-diabetic effects, GC-1 was steadily administered by our NMD, consisting of an implantable nanochannel membrane, as an alternative to conventional daily administration, which is subject to compliance issues in clinical settings...
July 27, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27452800/thyroid-stimulating-hormone-improves-insulin-sensitivity-in-skeletal-muscle-cells-via-camp-pka-creb-pathway-dependent-upregulation-of-insulin-receptor-substrate-1-expression
#16
Min Kyong Moon, Geun Hyung Kang, Hwan Hee Kim, Sun Kyoung Han, Young Do Koo, Sun Wook Cho, Ye An Kim, Byung-Chul Oh, Do Joon Park, Sung Soo Chung, Kyong Soo Park, Young Joo Park
Thyroid-stimulating hormone (TSH) receptor is expressed in extrathyroidal tissues such as hepatocytes, adipocytes, and skeletal muscle, which suggests a possible novel role of TSH in various metabolic processes in extrathyroidal tissues independent of thyroid hormones. We investigated whether TSH has any effects on glucose tolerance and insulin sensitivity in the skeletal muscle using diet-induced obesity (DIO) mouse models and rodent skeletal muscle cells. TSH improved glucose tolerance in DIO mice and this was associated with an improvement of skeletal muscle insulin sensitivity resulting from the increased expression of insulin receptor substrate (IRS)-1 protein and mRNA therein...
November 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27393002/association-of-serum-thyrotropin-with-anthropometric-markers-of-obesity-in-the-general-population
#17
Daniel Tiller, Till Ittermann, Karin H Greiser, Christa Meisinger, Carsten Agger, Albert Hofman, Betina Thuesen, Allan Linneberg, Robin Peeters, Oscar Franco, Margit Heier, Alexander Kluttig, Karl Werdan, Bruno Stricker, Sabine Schipf, Marcello Markus, Marcus Dörr, Henry Völzke, Johannes Haerting
BACKGROUND: Except from associations study with body weight, there are few longitudinal data regarding the association between thyroid function and anthropometric measurements such as waist circumference, waist-to-hip ratio, or waist-to height ratio. OBJECTIVE: This study aimed to investigate the association of thyrotropin (TSH) at baseline with changes in different anthropometric markers between baseline and follow-up in the general population. METHOD: Data were used from four population-based longitudinal cohort studies and one population-based cross-sectional study...
September 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27366725/hypothyroidism-and-obesity-an-intriguing-link
#18
REVIEW
Debmalya Sanyal, Moutusi Raychaudhuri
According to common perception, hypothyroidism is held responsible for obesity. However, linking them causally is controversial. Overt hypothyroidism is associated with modest weight gain, but there is a lack of clarity regarding subclinical hypothyroidism. Novel view indicates that changes in thyroid-stimulating hormone (TSH) could well be secondary to obesity. The increasing prevalence of obesity further confounds definition of normal TSH range in population studies. Thyroid autoantibody status may help in establishing the diagnosis of subclinical hypothyroidism in obesity...
July 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27343633/serum-tsh-levels-are-associated-with-cardiovascular-risk-factors-in-overweight-and-obese-adolescents
#19
Luciana Lopes de Souza, Erika Paniago Guedes, Patrícia Fátima Dos Santos Teixeira, Rodrigo Oliveira Moreira, Amelio Fernando Godoy-Matos, Mario Vaisman
OBJECTIVE: To investigate the relationship between serum thyrotropin (TSH), insulin resistance (IR), and cardiovascular risk factors (CRF) in a sample of overweight and obese Brazilian adolescents. METHODS: A retrospective, longitudinal analysis of 199 overweight and obese pubescent adolescents was performed. The TSH and free T4 (fT4) levels, anthropometric measurements, and laboratory test results of these patients were analyzed. RESULTS: 27 individuals (13...
September 2016: Jornal de Pediatria
https://www.readbyqxmd.com/read/27321605/abnormal-thyroid-stimulating-hormone-and-chronic-kidney-disease-in-elderly-adults-in-taipei-city
#20
Mei-Hsing Chuang, Kuo-Meng Liao, Yao-Min Hung, Paul Yung-Pou Wang, Yi-Chang Chou, Pesus Chou
OBJECTIVES: To examine whether older people with abnormal thyroid function are more likely to develop chronic kidney disease (CKD) over a 5-year follow-up period. DESIGN: Retrospective cohort study. SETTING: Health examination data from the Taipei Databank for Public Health Analysis. PARTICIPANTS: Individuals aged 65 and older (N = 41,454). MEASUREMENTS: Thyroid-stimulating hormone (TSH) levels were repeatedly measured, and subjects were categorized into four thyroid function groups (hyperthyroid, euthyroid, subclinical hypothyroid, overt hypothyroid)...
June 2016: Journal of the American Geriatrics Society
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