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https://www.readbyqxmd.com/read/29452573/the-effect-of-metformin-treatment-in-obese-insulin-resistant-patients-with-euthyroid-goiter
#1
Nicoleta Răcătăianu, Sorana Daniela Bolboacă, Adela-Viviana Sitar-Tăut, Smaranda Mârza, Daniela Moga, Ana Valea, Cristina Ghervan
Objective The study's objective was to evaluate the thyroid parameters in obese insulin-resistant patients with euthyroid diffuse or nodular goiter, following Metformin treatment. Patients and methods The study was experimental, open, and prospective. Fifty-three patients aged 18-68 were enrolled for two years. Obese insulin-resistant patients (cut-off Homeostasis-Model-Assessment of Insulin Resistance-HOMA-IR ≥ 2.5) with euthyroid nodular/diffuse goiter were included. Subjects with diabetes, hypo-/hyper-thyroidism, autoimmune thyroiditis, psychiatric disorders, liver or heart failure were excluded...
February 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29412382/thyroid-disorders-in-obese-patients-does-insulin-resistance-make-a-difference
#2
Nicoleta Răcătăianu, Nicoleta Leach, Cosmina Ioana Bondor, Smaranda Mârza, Daniela Moga, Ana Valea, Cristina Ghervan
OBJECTIVE: The aim of this study was to evaluate the association between insulin resistance and thyroid pathology in obese patients, and compare the results between insulin-resistant and noninsulin-resistant patients. SUBJECTS AND METHODS: Obese/nondiabetic patients, aged 18-70 years, attending the outpatient endocrinology service for 2 years were consecutively included. We evaluated the patients' fasting plasma glucose, insulin, homeostasis model assessment of insulin resistance index (HOMA-IR), thyroid-stimulating hormone (TSH), free thyroxine (FT4), antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (Tg-Ab), and thyroid ultrasound...
December 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29388360/beneficial-effects-of-thyroid-hormone-on-adipose-inflammation-and-insulin-sensitivity-of-obese-wistar-rats
#3
Ana C Panveloski-Costa, Caroline Serrano-Nascimento, Paula Bargi-Souza, Leonice L Poyares, Gabriela de S Viana, Maria T Nunes
Thyroid hormones play an important role in glucose metabolism and there is evidence of increased prevalence of thyroid dysfunction in obese and diabetic patients. This study aimed at evaluating the thyroid function and the effects of the triiodothyronine (T3) treatment on glycemia control, insulin sensitivity and subclinical inflammation in cafeteria-diet-induced obesity in rats. Obesity was induced in male Wistar rats by offering a cafeteria diet and a subset of the obese rats was treated with T3 (1.5 μg per 100 g of body weight) for a 28-day period...
February 2018: Physiological Reports
https://www.readbyqxmd.com/read/29374470/association-of-thyroid-nodules-with-adiposity-a-community-based-cross-sectional-study-in-china
#4
Bin Song, Zhihua Zuo, Juan Tan, Jianjin Guo, Weiping Teng, Yibing Lu, Chao Liu
BACKGROUND: The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether thyroid nodules are associated with overweight and obesity, as defined with body mass index (BMI) and waist circumference. METHODS: The study included 1482 subjects (≥20 years of age; residing in Nanjing, China) receiving questionnaire interview, anthropometric measurements, laboratory tests and thyroid ultrasonography in 2009-2010...
January 27, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29328881/factors-affecting-the-virological-response-among-chronic-hepatitis-c-virus-patients-in-yemen
#5
Zaid Mutahar Mohammed Alezzi, Ayman Yosry Abd El Rehim, Waleed Fouad Fathallah, Mansour Ali Alamrani, Fouad Hezam Othman
Hepatitis C virus (HCV) infection is increasingly seen as a major public health problem, threat, and concern worldwide. In Yemen about 1.7% of the population is infected with chronic hepatitis C. This study aimed to detect the predictors for response to pegylated interferon and ribavirin (Peg-IFN/RBV) in chronic HCV Yemeni patients. The study was conducted on 100 patients with chronic HCV who received Peg-IFN/RBV in the 48th Military Hospital in Sana'a Yemen, from 2011 to 2013. All patients were subjected to complete history taking, thorough clinical examinations, routine laboratory investigation, and abdominal ultrasonography...
January 2018: Journal of Interferon & Cytokine Research
https://www.readbyqxmd.com/read/29320782/thyroid-hormone-status-in-overweight-children-with-attention-deficit-hyperactivity-disorder
#6
Christian Langrock, Johannes Hebebrand, Katharina Radowksi, Eckard Hamelmann, Thomas Lücke, Martin Holtmann, Tanja Legenbauer, Börge Schmidt, Mirjam Frank, Karl-Heinz Jöckel, Thomas Reinehr
BACKGROUND: There is an ongoing discussion whether thyroid hormones are involved in the development and course of attention deficit/hyperactivity disorder (ADHD). Since obesity is associated with both higher thyroid-stimulating hormone (TSH) and free triiodothyronine (fT3) concentrations and increased rates of ADHD, we hypothesized that overweight children with ADHD show higher TSH and fT3 concentrations compared to overweight children without ADHD. METHODS: TSH, fT3, fT4, and leptin levels were analyzed in 230 children (60...
January 10, 2018: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/29306458/impact-of-subclinical-hypothyroidism-on-clinical-outcomes-following-percutaneous-coronary-intervention
#7
Yonggu Lee, Young-Hyo Lim, Jeong-Hun Shin, Jinkyu Park, Jinho Shin
BACKGROUND: Similar to overt hypothyroidism, subclinical hypothyroidism (SCH) has been reported to increase the risk of cardiovascular disease. However, the influence of SCH on clinical outcomes following percutaneous coronary intervention (PCI) remains unclear. METHODS: We performed a prospective cohort study. SCH was defined as a thyroid-stimulating hormone (TSH) level ≥4.5mIU/l and a normal level of free thyroxine (FT4). A composite event was defined as the combination of cardiac death, non-fatal myocardial infarction (MI) and repeat revascularization...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29249684/thyroid-hormones-lipid-profile-and-anthropometric-changes-after-programmed-weight-loss-in-palestinian-obese-adult-females
#8
Saleh Mwafy, Maged Yassin, Raed Mousa
OBJECTIVE: we aimed to investigate the changes in thyroid hormones, lipid profile and anthropometric measures after programmed weight loss in Palestinian obese adult females MATERIALS AND METHODS: This prospective study included 94 obese female (20-50 years old) as cases and 94 Non-obese of same age as controls for baseline comparisons. Obese female were assigned for low calorie diet (1200-1500 Kcal/day) in addition to a daily program of therapeutic exercise for six month. Parameters were measured, statistically analyzed and compared with control before and after study...
December 14, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29244733/the-association-of-triiodothyronine-to-thyroxine-ratio-with-body-mass-index-in-obese-nigerian-children-and-adolescents
#9
Mathias Abiodun Emokpae, Progress Arhenrhen Obazelu
The interest in the relationship between thyroid dysfunction and obesity is on the increase. This study compares the triiodothyronine-to-thyroxine (T3/T4) ratio in obese and lean children and adolescents, and correlates thyroid hormones with body mass index (BMI) in obese Nigerian children. It is a retrospective study of records of 76 obese children and adolescents with a BMI of 31.7 ± 0.1 kg/m² (26 males aged 10.9 ± 0.35 years, and 50 females aged 10.8 ± 0.4 years) that were referred to the laboratory for thyroid hormone evaluation because of their obese status...
December 15, 2017: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29223283/regulatory-aspects-of-the-human-hypothalamus-pituitary-thyroid-axis
#10
REVIEW
Ferdinand Roelfsema, Anita Boelen, Andries Kalsbeek, Eric Fliers
Thyroid hormones are essential for growth, differentiation and metabolism during prenatal and postnatal life. The hypothalamus-pituitary-thyroid (HPT)-axis is optimized for these actions. Knowledge of this hormonal axis is derived from decades of experiments in animals and man, and more recently from spontaneous mutations in man and constructed mutations in mice. This review examines the HPT-axis in relation to 24 h TSH profiles in men in various physiological and pathophysiological conditions, including obesity, age, longevity, and primary as well as central hypothyroidism...
October 2017: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29208878/study-of-thyroid-disorders-among-type-2-diabetic-patients-attending-a-tertiary-care-hospital
#11
N Z Khan, M A Muttalib, G S Sultana, F A Mishu, A Nesa
Type 2 diabetes mellitus (T2DM) and thyroid disorders (TD) are the two most common endocrine disorders in clinical practice. Unrecognized thyroid disorders may adversely affect the metabolic control and add more risk to an already predisposing type 2 diabetes mellitus. The objective of the study is to find out the percentage of hypothyroidism and hyperthyroidism in patients with type 2 diabetes mellitus and non diabetic subjects. This cross-sectional study was conducted in the department of Biochemistry and outpatient Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh from July 2014 to June 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29144813/diagnosing-and-monitoring-endocrine-dysfunction-diabetes-and-obesity-in-a-cohort-of-adult-survivors-of-childhood-cancer
#12
Victoria Rollins Hudspeth, Stuart Harrison Gold, David Robert Clemmons
OBJECTIVE: 5-year survival for childhood cancer has increased to 80%, resulting in a growing population of adult survivors of childhood cancer (ASOCC). Long-term endocrine dysfunction is as high as 63% when screened in research protocols. The purpose of this study was to evaluate the prevalence of endocrine testing, endocrine dysfunction, diabetes, obesity, and endocrinologist visits outside of a research screening protocol. METHODS: Retrospective chart review was performed for 176 ASOCC who were diagnosed with cancer before age 18, followed at least 10 years, were now at least 18, and had survived to the time of chart review...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29108812/correlation-of-brown-adipose-tissue-with-other-body-fat-compartments-and-patient-characteristics-a-retrospective-analysis-in-a-large-patient-cohort-using-pet-ct
#13
Cornelia Brendle, Matthias K Werner, Maria Schmadl, Christian la Fougère, Konstantin Nikolaou, Norbert Stefan, Christina Pfannenberg
RATIONALE AND OBJECTIVES: The objective of this study was to assess the relationship of brown adipose tissue (BAT) activity with different fat compartments of the body, body mass index (BMI), outdoor temperature, thyroid-stimulating hormone (TSH) levels, blood glucose, age, and sex in a large patient population using F-18-fluordesoxyglucose positron emission tomography-computer tomography (FDG-PET/CT) scans obtained under thermoneutral conditions. MATERIALS AND METHODS: FDG-PET/CT scans of 4852 patients were retrospectively analyzed for BAT activity...
November 3, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29083246/reduced-insulin-sensitivity-in-differentiated-thyroid-cancer-patients-with-suppressed-tsh
#14
Thaís Gomes De Melo, Aglecio Luiz Souza, Elizabeth Ficher, Arlete Maria Fernandes, Ligia Vera Montali Da Assumpção, Sarah Monte Alegre, Denise Engelbrecht Zantut-Wittmann
OBJECTIVE: TSH-suppression is a therapy for thyroid cancer management, but it may lead to adverse effects, which should be balanced with its benefits. Previous studies evaluating the consequences of TSH suppression on insulin sensitivity have only been done with indirect techniques, and results were controversial. Therefore, we aimed to assess insulin sensitivity in patients with thyroid cancer and suppressed thyroid-stimulating hormone (TSH) with the most appropriate direct method (hyperinsulinemic-euglycemic clamp) in order to get a more conclusive response about the topic...
October 30, 2017: Endocrine Research
https://www.readbyqxmd.com/read/29071498/trocar-site-hernia-following-laparoscopic-cholecystectomy-a-10-year-single-center-experience
#15
G Chatzimavroudis, B Papaziogas, I Galanis, I Koutelidakis, S Atmatzidis, P Evangelatos, N Voloudakis, A Ananiadis, A Doundis, E Christoforidis
INTRODUCTION: Laparoscopic cholecystectomy (LC) is the gold standard of treatment for patients with symptomatic cholelithiasis. Compared to open cholecystectomy, LC is associated with significantly lower postoperative complications. Trocar site hernia (TSH) is an uncommon, but potentially dangerous, complication of LC. The aim of this study was to evaluate the incidence of TSH following LC. METHODS: The records of all patients who underwent elective LC between January 2004 and December 2013 were retrospectively reviewed...
December 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29054175/effect-of-roux-en-y-gastric-bypass-on-thyroid-function-in-euthyroid-patients-with-obesity-and-type-2-diabetes
#16
Fangyuan Liu, Jianzhong Di, Haoyong Yu, Junfeng Han, Yuqian Bao, Weiping Jia
BACKGROUND: The impact of bariatric surgery on thyroid hormone levels is poorly understood. OBJECTIVES: To investigate changes in serum-free thyroxine (FT4) and thyroid-stimulating hormone (TSH) after Roux-en-Y gastric bypass (RYGB) in euthyroid patients with obesity and type 2 diabetes. SETTING: University Hospital, China. METHODS: Eighty-one euthyroid Chinese patients with obesity and type 2 diabetes who underwent RYGB, and 20 healthy volunteers were enrolled in this retrospective study...
October 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29039052/effect-of-bariatric-surgery-on-thyroid-function-in-obese-patients-a-systematic-review-and-meta-analysis
#17
REVIEW
Bingsheng Guan, YanYa Chen, Jingge Yang, Wah Yang, Cunchuan Wang
We aimed to make a meta-analysis regarding the effect of bariatric surgery on thyroid function in obese patients. PubMed, EMBASE, CENTRAL, and four Chinese databases were searched for clinical studies. Data were pooled using Review Manager 5.3, and subgroup and sensitivity analyses were performed if necessary and feasible. As a result, 24 articles were included into meta-analysis. Bariatric surgery was associated with significant decrease in TSH, FT3, and T3 levels. However, FT4, T4, and rT3 levels were not significantly changed postoperatively...
October 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29037214/thyroid-function-and-metabolic-syndrome-in-the-population-based-lifelines-cohort-study
#18
Bruce H R Wolffenbuttel, Hanneke J C M Wouters, Sandra N Slagter, Robert P van Waateringe, Anneke C Muller Kobold, Jana V van Vliet-Ostaptchouk, Thera P Links, Melanie M van der Klauw
BACKGROUND: The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to MetS prevalence in a large population-based study...
October 16, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29023978/weight-gain-after-treatment-of-graves-disease-in-children
#19
G Todd Alonso, Shona Rabon, Perrin C White
OBJECTIVE: The frequency of and risk factors for weight gain in children treated for Graves disease have not been described. We evaluated change in BMI Z score and predictors of weight gain in this population. DESIGN: Retrospective review of data from January 2000 to July 2011. PATIENTS: 222 children and adolescents with Graves' disease (ages 2-18 years) evaluated following radioactive iodine administration (RAI) (n=101), thyroidectomy (n=9), and initiation of medical therapy (n=112)...
October 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28969110/variations-of-adipokines-and-insulin-resistance-in-primary-hypothyroidism
#20
Kaushik Kar, Satwika Sinha
INTRODUCTION: Hypothyroidism is a common concern in endocrinology practice, which plays a significant role in metabolic and development processes. Obesity, hyperlipidaemia and hypertension may complicate hypothyroidism. Recent studies have shown that cytokines like leptin and adiponectin, secreted by adipose tissue and exert their endocrinal functions by modulating appetite, obesity and insulin sensitivity in conjunction with thyroid hormones. Interrelation between thyroid hormone, insulin resistance and adipokines are not yet clear...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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