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https://www.readbyqxmd.com/read/29208878/study-of-thyroid-disorders-among-type-2-diabetic-patients-attending-a-tertiary-care-hospital
#1
N Z Khan, M A Muttalib, G S Sultana, F A Mishu, A Nesa
Type 2 diabetes mellitus (T2DM) and thyroid disorders (TD) are the two most common endocrine disorders in clinical practice. Unrecognized thyroid disorders may adversely affect the metabolic control and add more risk to an already predisposing type 2 diabetes mellitus. The objective of the study is to find out the percentage of hypothyroidism and hyperthyroidism in patients with type 2 diabetes mellitus and non diabetic subjects. This cross-sectional study was conducted in the department of Biochemistry and outpatient Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh from July 2014 to June 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29144813/diagnosing-and-monitoring-endocrine-dysfunction-diabetes-and-obesity-in-a-cohort-of-adult-survivors-of-childhood-cancer
#2
Victoria Rollins Hudspeth, Stuart Harrison Gold, David Robert Clemmons
OBJECTIVE: 5-year survival for childhood cancer has increased to 80%, resulting in a growing population of adult survivors of childhood cancer (ASOCC). Long-term endocrine dysfunction is as high as 63% when screened in research protocols. The purpose of this study was to evaluate the prevalence of endocrine testing, endocrine dysfunction, diabetes, obesity, and endocrinologist visits outside of a research screening protocol. METHODS: Retrospective chart review was performed for 176 ASOCC who were diagnosed with cancer before age 18, followed at least 10 years, were now at least 18, and had survived to the time of chart review...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29108812/correlation-of-brown-adipose-tissue-with-other-body-fat-compartments-and-patient-characteristics-a-retrospective-analysis-in-a-large-patient-cohort-using-pet-ct
#3
Cornelia Brendle, Matthias K Werner, Maria Schmadl, Christian la Fougère, Konstantin Nikolaou, Norbert Stefan, Christina Pfannenberg
RATIONALE AND OBJECTIVES: The objective of this study was to assess the relationship of brown adipose tissue (BAT) activity with different fat compartments of the body, body mass index (BMI), outdoor temperature, thyroid-stimulating hormone (TSH) levels, blood glucose, age, and sex in a large patient population using F-18-fluordesoxyglucose positron emission tomography-computer tomography (FDG-PET/CT) scans obtained under thermoneutral conditions. MATERIALS AND METHODS: FDG-PET/CT scans of 4852 patients were retrospectively analyzed for BAT activity...
November 3, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29083246/reduced-insulin-sensitivity-in-differentiated-thyroid-cancer-patients-with-suppressed-tsh
#4
Thaís Gomes De Melo, Aglecio Luiz Souza, Elizabeth Ficher, Arlete Maria Fernandes, Ligia Vera Montali Da Assumpção, Sarah Monte Alegre, Denise Engelbrecht Zantut-Wittmann
OBJECTIVE: TSH-suppression is a therapy for thyroid cancer management, but it may lead to adverse effects, which should be balanced with its benefits. Previous studies evaluating the consequences of TSH suppression on insulin sensitivity have only been done with indirect techniques, and results were controversial. Therefore, we aimed to assess insulin sensitivity in patients with thyroid cancer and suppressed thyroid-stimulating hormone (TSH) with the most appropriate direct method (hyperinsulinemic-euglycemic clamp) in order to get a more conclusive response about the topic...
October 30, 2017: Endocrine Research
https://www.readbyqxmd.com/read/29071498/trocar-site-hernia-following-laparoscopic-cholecystectomy-a-10-year-single-center-experience
#5
G Chatzimavroudis, B Papaziogas, I Galanis, I Koutelidakis, S Atmatzidis, P Evangelatos, N Voloudakis, A Ananiadis, A Doundis, E Christoforidis
INTRODUCTION: Laparoscopic cholecystectomy (LC) is the gold standard of treatment for patients with symptomatic cholelithiasis. Compared to open cholecystectomy, LC is associated with significantly lower postoperative complications. Trocar site hernia (TSH) is an uncommon, but potentially dangerous, complication of LC. The aim of this study was to evaluate the incidence of TSH following LC. METHODS: The records of all patients who underwent elective LC between January 2004 and December 2013 were retrospectively reviewed...
October 25, 2017: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29054175/effect-of-roux-en-y-gastric-bypass-on-thyroid-function-in-euthyroid-patients-with-obesity-and-type-2-diabetes
#6
Fangyuan Liu, Jianzhong Di, Haoyong Yu, Junfeng Han, Yuqian Bao, Weiping Jia
BACKGROUND: The impact of bariatric surgery on thyroid hormone levels is poorly understood. OBJECTIVES: To investigate changes in serum-free thyroxine (FT4) and thyroid-stimulating hormone (TSH) after Roux-en-Y gastric bypass (RYGB) in euthyroid patients with obesity and type 2 diabetes. SETTING: University Hospital, China. METHODS: Eighty-one euthyroid Chinese patients with obesity and type 2 diabetes who underwent RYGB, and 20 healthy volunteers were enrolled in this retrospective study...
October 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29039052/effect-of-bariatric-surgery-on-thyroid-function-in-obese-patients-a-systematic-review-and-meta-analysis
#7
REVIEW
Bingsheng Guan, YanYa Chen, Jingge Yang, Wah Yang, Cunchuan Wang
We aimed to make a meta-analysis regarding the effect of bariatric surgery on thyroid function in obese patients. PubMed, EMBASE, CENTRAL, and four Chinese databases were searched for clinical studies. Data were pooled using Review Manager 5.3, and subgroup and sensitivity analyses were performed if necessary and feasible. As a result, 24 articles were included into meta-analysis. Bariatric surgery was associated with significant decrease in TSH, FT3, and T3 levels. However, FT4, T4, and rT3 levels were not significantly changed postoperatively...
October 16, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29037214/thyroid-function-and-metabolic-syndrome-in-the-population-based-lifelines-cohort-study
#8
Bruce H R Wolffenbuttel, Hanneke J C M Wouters, Sandra N Slagter, Robert P van Waateringe, Anneke C Muller Kobold, Jana V van Vliet-Ostaptchouk, Thera P Links, Melanie M van der Klauw
BACKGROUND: The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to MetS prevalence in a large population-based study...
October 16, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29023978/weight-gain-after-treatment-of-graves-disease-in-children
#9
G Todd Alonso, Shona Rabon, Perrin C White
OBJECTIVE: The frequency of and risk factors for weight gain in children treated for Graves disease have not been described. We evaluated change in BMI Z score and predictors of weight gain in this population. DESIGN: Retrospective review of data from January 2000 to July 2011. PATIENTS: 222 children and adolescents with Graves' disease (ages 2-18 years) evaluated following radioactive iodine administration (RAI) (n=101), thyroidectomy (n=9), and initiation of medical therapy (n=112)...
October 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28969110/variations-of-adipokines-and-insulin-resistance-in-primary-hypothyroidism
#10
Kaushik Kar, Satwika Sinha
INTRODUCTION: Hypothyroidism is a common concern in endocrinology practice, which plays a significant role in metabolic and development processes. Obesity, hyperlipidaemia and hypertension may complicate hypothyroidism. Recent studies have shown that cytokines like leptin and adiponectin, secreted by adipose tissue and exert their endocrinal functions by modulating appetite, obesity and insulin sensitivity in conjunction with thyroid hormones. Interrelation between thyroid hormone, insulin resistance and adipokines are not yet clear...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28945907/response-to-letter-association-of-tsh-with-cardiovascular-disease-risk-in-overweight-and-obese-children-during-lifestyle-intervention
#11
Jogchum Plat, Anita C E Vreugdenhil
No abstract text is available yet for this article.
September 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28945904/letter-to-the-editor-association-of-tsh-with-cardiovascular-disease-risk-in-overweight-and-obese-children-during-lifestyle-intervention
#12
Giorgio Radetti, Silvia Longhi, Alessandro Sartorio, Graziano Grugni
No abstract text is available yet for this article.
September 18, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28945847/maternal-thyroid-antibodies-associates-with-cardiometabolic-risk-factors-in-children-at-the-age-of-16
#13
Anna-Leena Heikkinen, Fanni Päkkilä, Anna-Liisa Hartikainen, Marja Vääräsmäki, Tuija Männistö, Eila Suvanto
Context and Objective: The objective of this study was to determine the effects of maternal thyroid dysfunction or antibodies during pregnancy on the cardiometabolic risk factors in children. Design, Setting, and Participants: This prospective population-based cohort study, Northern Finland Birth Cohort 1986, included all pregnancies within a year in the area. Maternal serum samples were collected before the 20th week of gestation and analyzed for thyrotropin, free T4, thyroid-peroxidase antibodies (TPO-Abs), and thyroglobulin antibodies (Tg-Abs)...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28901333/a-paleolithic-type-diet-results-in-iodine-deficiency-a-2-year-randomized-trial-in-postmenopausal-obese-women
#14
S Manousou, M Stål, C Larsson, C Mellberg, B Lindahl, R Eggertsen, L Hulthén, T Olsson, M Ryberg, S Sandberg, H F Nyström
BACKGROUND/OBJECTIVES: Different diets are used for weight loss. A Paleolithic-type diet (PD) has beneficial metabolic effects, but two of the largest iodine sources, table salt and dairy products, are excluded. The objectives of this study were to compare 24-h urinary iodine concentration (24-UIC) in subjects on PD with 24-UIC in subjects on a diet according to the Nordic Nutrition Recommendations (NNR) and to study if PD results in a higher risk of developing iodine deficiency (ID), than NNR diet...
September 13, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28872086/-subclinical-hypothyroidism-and-endocrine-metabolic-characteristics-in-women-with-polycystic-ovary-syndrome
#15
Fangzhi Yue, Dongmei Zhang, Fei Gong, Li Zhang, Zhixiang Sun, Minxiang Lei
To explore associations of subclinical hypothyroidism (SCH) with endocrine metabolic characteristics in women with polycystic ovary syndrome (PCOS).
 Methods: A total of 321 women who were newly diagnosed as PCOS were recruited from two endocrine outpatient clinics. The diagnosis of PCOS was established according to the 2003 Rotterdam consensus criteria. Thyroid function was examined by chemiluminescent immunoassay. Patients who had normal free thyroxine (FT4) were divided into different SCH subgroups according to two thyroid stimulating hormone (TSH) cutoff points (4...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28843650/relationship-of-metabolic-syndrome-and-its-components-with-thyroid-dysfunction-in-algerian-patients
#16
Mohamed Larbi Hamlaoui, Ammar Ayachi, Aoulia Dekaken, Adel Gouri
AIMS: The aim of this study is to evaluate the prevalence of the metabolic syndrome and its compounds in subjects with different thyroid status. MATERIALS AND METHODS: A prospective cross-sectional study was conducted in the internal medicine department at El Okbi Hospital of Guelma (East of Algeria) from January 2014 to September 2015. Eighty six patients attending the specialist consultation for suspected thyroid disorders were included in the study. Gender; blood pressure; body mass index; and serum levels of fasting glucose, total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol, and triglyceride were compared between subjects with hypothyroidism, hyperthyroidism and euthyroidism...
August 10, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28766504/the-association-between-serum-tsh-levels-and-bmi-percentiles-in-children-with-primary-hypothyroidism-that-are-chemically-euthyroid-on-levothyroxine-replacement
#17
Asma Shaoba, Sanjib Basu, Stelios Mantis, Carla Minutti
OBJECTIVE: To determine if there is a association between TSH levels and BMI percentiles in children with primary hypothyroidism who are chemically euthyroid and on treatment with levothyroxine. METHODS: Retrospective cross-sectional study, consisting of review of medical records from RUSH Medical Center and Stroger Hospital, Chicago, IL, U.SA. Children (seen in clinic from 2008-2014) with primary hypothyroidism who were chemically euthyroid and on treatment with levothyroxine for at least 6 months were included in the study...
August 2, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28766267/iodine-status-after-bariatric-surgery-a-prospective-10-year-report-from-the-swedish-obese-subjects-sos-study
#18
Sofia Manousou, Lena M S Carlsson, Robert Eggertsen, Lena Hulthén, Peter Jacobson, Kerstin Landin-Wilhelmsen, Penelope Trimpou, Per-Arne Svensson, Helena Filipsson Nyström
CONTEXT: Bariatric surgery can lead to nutrient deficiencies. Gastric by-pass (GBP) entails restriction and malabsorption, whereas, vertical banded gastroplasty (VBG) is only restrictive. OBJECTIVE: The objective of this study is to study whether GBP-patients develop iodine deficiency from malabsorption, and if GBP- and VBG-patients develop lower 24-h urinary iodine excretion (24-UIE) than obese non-operated controls (OB-controls) due to lower iodine intake. DESIGN: The Swedish Obese Subjects (SOS) study is a prospective, non-randomized study of 4047 obese patients included 1987-2001, who chose bariatric surgery or non-surgical treatment...
August 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28725979/effect-of-weight-loss-after-bariatric-surgery-on-thyroid-stimulating-hormone-levels-in-patients-with-morbid-obesity-and-normal-thyroid-function
#19
João Sérgio Neves, Sofia Castro Oliveira, Pedro Souteiro, Jorge Pedro, Daniela Magalhães, Vanessa Guerreiro, Rita Bettencourt-Silva, Maria Manuel Costa, Ana Cristina Santos, Joana Queirós, Ana Varela, Paula Freitas, Davide Carvalho
BACKGROUND: Several studies have reported that morbid obesity is associated with increased thyroid-stimulating hormone (TSH) levels. However, it is not clear what is the impact of bariatric surgery on postoperative thyroid function. The aim of this study was to evaluate the effect of weight loss after bariatric surgery on TSH levels in euthyroid patients with morbid obesity. METHODS: We performed a retrospective observational study of 949 euthyroid patients (86...
July 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28711660/a-novel-deletion-involving-gnas-exon-1-causes-php1a-and-further-refines-the-region-required-for-normal-methylation-at-exon-a-b
#20
Monica Reyes, Anara Karaca, Murat Bastepe, Nese Ersoz Gulcelik, Harald Jüppner
GNAS exons 1-13 encode the biallelically expressed alpha-subunit of the stimulatory G protein (Gαs). Additional transcripts derived from this locus use alternative first exons that undergo parent-specific methylation, thus allowing transcription only from the non-modified allele. Pseudohypoparathyroidism type Ia (PHP1A) is characterized by Albright's Hereditary Osteodystrophy (AHO) and resistance to multiple hormones; this disorder is caused by maternal inactivating mutations involving Gαs exons. In contrast, pseudohypoparathyroidism type Ib (PHP1B) is characterized mostly by resistance to PTH and often mild TSH resistance, usually without AHO features...
October 2017: Bone
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