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https://www.readbyqxmd.com/read/28101577/viscumins-functionally-modulate-cell-motility-associated-gene-expression
#1
Sonja Schötterl, Miriam Hübner, Angela Armento, Vivien Veninga, Naita Maren Wirsik, Simon Bernatz, Hans Lentzen, Michel Mittelbronn, Ulrike Naumann
In Europe extracts from Viscum album L., the European white-berry mistletoe, are widely used as a complementary cancer therapy. Viscumins (mistletoe lectins, ML) have been scrutinized as important active components of mistletoe and exhibit a variety of anticancer effects such as stimulation of the immune system, induction of cytotoxicity, reduction of tumor cell motility as well as changes in the expression of genes associated with cancer development and progression. By microarray expression analysis, quantitative RT-PCR and RT-PCR based validation of microarray data we demonstrate for the Viscum album extract Iscador Qu and for the lectins Aviscumine and ML-1 that in glioma cells these drugs differentially modulate the expression of genes involved in the regulation of cell migration and invasion, including processes modulating cell architecture and cell adhesion...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28090408/development-of-microsatellite-markers-for-viscum-coloratum-santalaceae-and-their-application-to-wild-populations
#2
Bo-Yun Kim, Han-Sol Park, Soonok Kim, Young-Dong Kim
PREMISE OF THE STUDY: Microsatellite primers were developed for Viscum coloratum (Santalaceae), a semiparasitic medicinal plant that is known for its anticancer properties. Due to excessive human harvesting and loss of suitable habitat of its populations, it has become a potentially threatened species requiring immediate conservation efforts. METHODS AND RESULTS: Based on transcriptome data for V. coloratum, 124 primer pairs were randomly selected for initial validation, of which 19 yielded polymorphic microsatellite loci, with two to six alleles per locus...
January 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28061770/viscumtt-induces-apoptosis-and-alters-iap-expression-in-osteosarcoma-in-vitro-and-has-synergistic-action-when-combined-with-different-chemotherapeutic-drugs
#3
Susann Kleinsimon, Gwenda Kauczor, Sebastian Jaeger, Angelika Eggert, Georg Seifert, Catharina Delebinski
BACKGROUND: Osteosarcoma is the most common bone tumor and is associated with a poor prognosis. Conventional therapies, surgery and chemotherapy, are still the standard but soon reach their limits. New therapeutic approaches are therefore needed. Conventional aqueous mistletoe extracts from the European mistletoe (Viscum album L.) are used in complementary cancer treatment. These commercial extracts are water-based and do not include water-insoluble compounds such as triterpenic acids...
January 7, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28045549/curcumin-and-viscum-album-extract-decrease-proliferation-and-cell-viability-of-soft-tissue-sarcoma-cells-an-in-vitro-analysis-of-eight-cell-lines-using-real-time-monitoring-and-colorimetric-assays
#4
K Harati, B Behr, A Daigeler, T Hirsch, F Jacobsen, M Renner, A Harati, C Wallner, M Lehnhardt, M Becerikli
BACKGROUND: The cytostatic effects of the polyphenol curcumin and Viscum album extract (VAE) were assessed in soft-tissue sarcoma (STS) cells. METHODS: Eight human STS cell lines were used: fibrosarcoma (HT1080), liposarcoma (SW872, T778, MLS-402), synovial sarcoma (SW982, SYO1, 1273), and malignant fibrous histiocytoma (U2197). Primary human fibroblasts served as control cells. Cell proliferation, viability, and cell index (CI) were analyzed by BrdU assay, MTT assay, and real-time cell analysis (RTCA)...
January 3, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28036032/inhibitory-effects-of-viscum-coloratum-extract-on-ige-antigen-activated-mast-cells-and-mast-cell-derived-inflammatory-mediator-activated-chondrocytes
#5
Jae-Myung Yoo, Ju-Hye Yang, Young Soo Kim, Hye Jin Yang, Won-Kyung Cho, Jin Yeul Ma
The accumulation and infiltration of mast cells are found in osteoarthritic lesions in humans and rodents. Nonetheless, the roles of mast cells in osteoarthritis are almost unknown. Although Viscum coloratum has various beneficial actions, its effect on allergic and osteoarthritic responses is unknown. In this study, we established an in vitro model of mast cell-mediated osteoarthritis and investigated the effect of the ethanol extract of Viscum coloratum (VEE) on IgE/antigen (IgE/Ag)-activated mast cells and mast cell-derived inflammatory mediator (MDIM)-stimulated chondrocytes...
December 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27933073/mistletoe-berry-outline-mapping-with-a-path-curve-function-and-recording-the-circadian-rhythm-of-their-phenotypic-shape-change
#6
Renatus Derbidge, Stephan Baumgartner, Peter Heusser
This paper presents a discovery: the change of the outline shape of mistletoe (Viscum album ssp. album) berries in vivo and in situ during ripening. It was found that a plant organ that is usually considered to merely increase in size actually changes shape in a specific rhythmic fashion. We introduce a new approach to chronobiological research on a macro-phenotypic scale to trace changes over long periods of time (with a resolution from hours to months) by using a dynamic form-determining parameter called Lambda (λ)...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27868169/articulatin-d-induces-apoptosis-via-activation-of-caspase-8-in-acute-t-cell-leukemia-cell-line
#7
Ruchi Mishra, Mrinal K Das, Savita Singh, Radhey Shyam Sharma, Sadhna Sharma, Vandana Mishra
Leukemia is among the most aggressive and prevalent human malignant carcinoma. Chemotherapy is the preferred therapeutic strategy; however, recurrence of cancer and non-selective cytotoxicity are the major concerns. Unlike synthetic chemotherapeutic agents, mistletoe ribosome-inactivating protein (RIP) displays anti-tumor function in various types of cancers. However, its effect on leukemia cells is little explored. In this study, we assessed the impact of Viscum articulatum RIP (Articulatin-D) on the survival of acute T-cell leukemia cells and the involved molecular and cellular mechanisms...
November 21, 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27593449/evaluation-of-seasonal-changes-of-triterpenic-acid-contents-in-viscum-album-from-different-host-trees
#8
Magdalena Wójciak-Kosior, Ireneusz Sowa, Kamila Pucek, Grażyna Szymczak, Ryszard Kocjan, Piotr Luchowski
CONTEXT: Viscum album L. (Loranthaceae) is a semi-parasitic plant used in pharmacy and medicine mostly for its hypotensive and anticancer activity. The effects may be related to the presence of triterpenic acids, such as betulinic (BA) and oleanolic (OA) acids. OBJECTIVES: In our investigations the content of triterpenic acids in V. album from different host trees depending on the season of harvest was determined. MATERIAL AND METHODS: V. album herb was dried and extracted with ethyl acetate using ultrasound energy...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27589063/multiple-active-compounds-from-viscum-album-l-synergistically-converge-to-promote-apoptosis-in-ewing-sarcoma
#9
Monika Twardziok, Susann Kleinsimon, Jana Rolff, Sebastian Jäger, Angelika Eggert, Georg Seifert, Catharina I Delebinski
Ewing sarcoma is the second most common bone cancer in children and adolescents, with poor prognosis and outcome in ~70% of initial diagnoses and 10-15% of relapses. Hydrophobic triterpene acids and hydrophilic lectins and viscotoxins from European mistletoe (Viscum album L.) demonstrate anticancer properties, but have not yet been investigated for Ewing sarcoma. Commercial Viscum album L. extracts are aqueous, excluding the insoluble triterpenes. We recreated a total mistletoe effect by combining an aqueous extract (viscum) and a triterpene extract (TT) solubilized with cyclodextrins...
2016: PloS One
https://www.readbyqxmd.com/read/27548121/parasitic-mistletoes-of-the-genera-scurrula-and-viscum-from-bench-to-bedside
#10
REVIEW
Ya Chee Lim, Rajan Rajabalaya, Shirley Huan Fang Lee, Kushan U Tennakoon, Quang-Vuong Le, Adi Idris, Ihsan N Zulkipli, Natasha Keasberry, Sheba R David
The mistletoes, stem hemiparasites of Asia and Europe, have been used as medicinal herbs for many years and possess sophisticated systems to obtain nutrients from their host plants. Although knowledge about ethnomedicinal uses of mistletoes is prevalent in Asia, systematic scientific study of these plants is still lacking, unlike its European counterparts. This review aims to evaluate the literature on Scurrula and Viscum mistletoes. Both mistletoes were found to have anticancer, antimicrobial, antioxidant and antihypertensive properties...
August 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27491866/interaction-of-a-standardized-mistletoe-viscum-album-preparation-with-antitumor-effects-of-trastuzumab-in-vitro
#11
U Weissenstein, M Kunz, K Urech, U Regueiro, S Baumgartner
BACKGROUND: Besides conventional anticancer therapy many breast cancer patients use complementary and alternative medicine (CAM) like the medicinal herb mistletoe (Viscum album L.). To gain more knowledge about possible herb-drug interactions between CAM and conventional anticancer medications, in the present in vitro study we investigated the effect of a standardized mistletoe preparation on the action of Trastuzumab, a drug used for the treatment of Her-2 positive breast cancer. METHODS: The Her-2 positive human breast carcinoma cell line SK-BR-3 was treated with Trastuzumab...
August 4, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27485618/health-services-research-of-integrative-oncology-in-palliative-care-of-patients-with-advanced-pancreatic-cancer
#12
Jan Axtner, Megan Steele, Matthias Kröz, Günther Spahn, Harald Matthes, Friedemann Schad
BACKGROUND: Pancreatic cancer has a dire prognosis and is associated with a high mortality. Palliative patients have special needs and often seek help in integrative oncological concepts (IO) that combine conventional and complementary therapies. Nevertheless there are few recommendations regarding IO in current cancer guidelines. The aims of this study were to report on implementation of IO in everyday palliative care and to analyze patient survival in advanced pancreatic cancer. METHODS: This multicenter observational study investigates the implementation of IO and length of survival of patients suffering from advanced pancreatic cancer (stage IV)...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27465545/intestinal-and-vascular-smooth-muscle-relaxant-effect-of-viscum-album-explains-its-medicinal-use-in-hyperactive-gut-disorders-and-hypertension
#13
Taous Khan, Sayyad Ali, Rahila Qayyum, Izhar Hussain, Fazli Wahid, Abdul Jabbar Shah
BACKGROUND: Viscum album has shown inhibitory effect on different smooth muscles but underlying mechanisms in gut and vascular smooth muscles are not well defined. Additionally, the plant has also importance in managing hyperactive gut and cardiovascular disorders. The current study was aimed to probe a pharmacological base of the smooth muscle relaxant effect of V. album in gut and vascular preparations. METHODS: V. album crude extract (Va. Cr) and its ethyl acetate fraction (Va...
July 27, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27445814/antioxidant-antinociceptive-and-cns-activities-of-viscum-orientale-and-high-sensitive-quantification-of-bioactive-polyphenols-by-uplc
#14
Amina Khatun, Mahmudur Rahman, Md Mahfizur Rahman, Hemayet Hossain, Ismet A Jahan, Mst Luthfun Nesa
Viscum orientale Willd. (Loranthaceae) has long been used in traditional medicine to treat pain, neuropharmacological disorders and various forms of tumor but not yet been reported. The aim of this study is to rationalize the traditional medicinal use of this plant by evaluating the methanol extract of V. orientale leaves (MEVOL) for anti-nociceptive, CNS depressant and antioxidant activities and to quantify the bioactive polyphenols present in this plant. Five polyphenolic compounds namely gallic acid, vanillic acid, caffeic acid, ellagic acid, and quercetin (17...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27443473/cardioprotective-effects-of-viscum-album-l-ssp-album-loranthaceae-on-isoproterenol-induced-heart-failure-via-regulation-of-the-nitric-oxide-pathway-in-rats
#15
Ahmet Karagöz, Sevgi Kesici, Aslı Vural, Murat Usta, Berna Tezcan, Tuna Semerci, Erhan Teker
OBJECTIVE: Viscum album L. has favorable cardiovascular effects including antihypertensive and vasorelaxant activity, and the nitric oxide (NO) pathway upregulation has been proposed to be the underlying mechanism. NO also plays an important role in the pathophysiology of heart failure. However, its effects on cardiac systolic function are unclear. METHODS: A total of 30 male Wistar albino rats at 12 weeks of age were randomly divided into three groups: control, isoproterenol-induced heart failure group (ISO), and isoproterenol-induced heart failure + V...
June 29, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27428940/differential-effects-of-viscum-album-preparations-on-the-maturation-and-activation-of-human-dendritic-cells-and-cd4%C3%A2-%C2%BA-t-cell-responses
#16
Chaitrali Saha, Mrinmoy Das, Emmanuel Stephen-Victor, Alain Friboulet, Jagadeesh Bayry, Srini V Kaveri
Extracts of Viscum album (VA); a semi-parasitic plant, are frequently used in the complementary therapy of cancer and other immunological disorders. Various reports show that VA modulates immune system and exerts immune-adjuvant activities that might influence tumor regression. Currently, several therapeutic preparations of VA are available and hence an insight into the mechanisms of action of different VA preparations is necessary. In the present study, we performed a comparative study of five different preparations of VA on maturation and activation of human dendritic cells (DCs) and ensuing CD4⁺ T cell responses...
July 14, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27261737/purification-characterization-and-anti-proliferation-activities-of-polysaccharides-extracted-from-viscum-coloratum-kom-nakai
#17
Yangyang Chai, Min Zhao
Three polysaccharides, VCP1, VCP2 and VCP3 were isolated from Viscum coloratum (Kom.) Nakai using DEAE-cellulose chromatography. VCP1 (32KDa) was composed of glucose, galactose, arabinose, rhamnose and mannose, while VCP2 (280KDa) and VCP3 (21KDa) were consisted of glucose, galactose, arabinose, rhamnose, mannose, glucuronic acid and galacturonic acid. The optical rotation was measured at 20+1°C. The characteristic absorptive bands of purified fraction were determined by FT-IR. (13)C NMR spectroscopy analysis showed that VCP1 was a neutral polysaccharide, and VCP2 and VCP3 were RG-I type pectin...
September 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27200103/a-fomitopsis-pinicola-jeseng-formulation-has-an-antiobesity-effect-and-protects-against-hepatic-steatosis-in-mice-with-high-fat-diet-induced-obesity
#18
Hoe-Yune Jung, Yosep Ji, Na-Ri Kim, Do-Young Kim, Kyong-Tai Kim, Bo-Hwa Choi
This study investigated the antiobesity effect of an extract of the Fomitopsis pinicola Jeseng-containing formulation (FAVA), which is a combination of four natural components: Fomitopsis pinicola Jeseng; Acanthopanax senticosus; Viscum album coloratum; and Allium tuberosum. High-fat diet- (HFD-) fed male C57BL/6J mice were treated with FAVA (200 mg/kg/day) for 12 weeks to monitor the antiobesity effect and amelioration of nonalcoholic fatty liver diseases (NAFLD). Body and white adipose tissue (WAT) weights were reduced in FAVA-treated mice, and a histological examination showed an amelioration of fatty liver in FAVA-treated mice without decreasing food consumption...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27110639/proliferation-apoptosis-and-invasion-effects-of-mistletoe-alkali-on-human-osteosarcoma-u2os-in-vitro
#19
Yan Ge, Yishu Wang, Lei Pang, Lihong Zhang, Yingxian Zhai, Houlan Zhou
OBJECTIVE: To evaluate the effects of mistletoe alkali on human Osteosarcoma cells (U2OS) in vitro. SUMMARY OF BACKGROUND DATA: Osteosarcoma is the most common primary malignant tumor of bone tumor, although there are a lot of therapies such as surgery, radiotherapy and chemotherapy, its prognosis is still very poor. There is increasing interest in the protective biological function of natural antioxidants contained in Chinese medicinal herbs, which are candidates for the prevention of tumors...
April 25, 2016: International Surgery
https://www.readbyqxmd.com/read/27105275/temporal-dynamic-of-parasite-mediated-linkages-between-the-forest-canopy-and-soil-processes-and-the-microbial-community
#20
Ana Mellado, Lourdes Morillas, Antonio Gallardo, Regino Zamora
Parasitic plants are important drivers of community and ecosystem properties. In this study, we identify different mechanisms by which mistletoe (Viscum album subsp. austriacum) can affect soil chemical and biological properties at different temporal stages of parasitism. We quantified the effect of parasitism on host growth and the number of frugivorous mutualists visiting the host canopy. Then we collected, identified, and weighed the organic matter input underneath tree canopies and analyzed its nutrient content...
September 2016: New Phytologist
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