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https://www.readbyqxmd.com/read/29659501/the-stability-of-medicinal-plant-micrornas-in-the-herb-preparation-process
#1
Wenyan Xie, Matthias F Melzig
Herbal medicine is now globally accepted as a valid alternative system of pharmaceutical therapies. Various studies around the world have been initiated to develop scientific evidence-based herbal therapies. Recently, the therapeutic potential of medicinal plant derived miRNAs has attracted great attraction. MicroRNAs have been indicated as new bioactive ingredients in medicinal plants. However, the stability of miRNAs during the herbal preparation process and their bioavailability in humans remain unclear...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29602283/korean-mistletoe-lectin-enhances-natural-killer-cell-cytotoxicity-via-upregulation-of-perforin-expression
#2
Younghoon Kim, Inbo Kim, Choon-Ho Park, Jong Bae Kim
BACKGROUND: Natural killer (NK) cells are crucial components of the innate immune system, providing the first line of defense against pathogens. In a previous study, we demonstrated prophylactic activity of water extract of Korean mistletoe (Viscum album coloratum) on tumor metastasis. However, the leading compound from water extract of Korean mistletoe was not clearly addressed. OBJECTIVE: The purpose of this research was mainly focused on addressing the effect of Korean mistletoe lectin (KMLC) on NK cell cytotoxicity, and the ability of cytokine secretion as well as its signal transduction, mitogen-activated protein kinase (MAPK) pathway...
March 31, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29600069/the-management-of-chemical-pleurodesis-with-viscum-album-in-patients-with-persistent-air-leakage
#3
Jae Bum Park, Song Am Lee, Woo Surng Lee, Yo Han Kim, Jae Joon Hwang
Background: Persistent air leak (PAL) after major pulmonary resection or involved with secondary lung disease is prevalent and associated with significant morbidity. Chemical pleurodesis is a practical therapeutic tool to manage the patients with PAL. Among various sclerosing substances, viscum album (fraxini) is considered effective and safe. The aim of this study was to evaluate the efficacy and safety of viscum album pleurodesis in patients with intractable prolonged air leakage. Methods: Between February 2013 and February 2015, 73 consecutive patients who underwent pleurodesis due to PAL were enrolled in this study...
January 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29556122/phenolic-compounds-from-viscum-album-tinctures-enhanced-antitumor-activity-in-melanoma-murine-cancer-cells
#4
Michelle Nonato de Oliveira Melo, Adriana Passos Oliveira, Adalgisa Felippe Wiecikowski, Renato Sampaio Carvalho, Juliana de Lima Castro, Felipe Alves Gomes de Oliveira, Henrique Marcelo Gualberto Pereira, Venicio Feo da Veiga, Marcia Marques Alves Capella, Leandro Rocha, Carla Holandino
Cancer is one of the biggest problems in public health worldwide. Plants have been shown important role in anticancer research. Viscum album L. (Santalaceae), commonly known as mistletoe, is a semi-parasitic plant that grows on different host trees. In complementary medicine, extracts from European mistletoe ( Viscum album L.) have been used in the treatment of cancer. The study was conducted to identify chemical composition and antitumor potential of Viscum album tinctures. Chemical analysis performed by high resolution chromatography equipped with high resolution mass spectrometer identified caffeic acid, chlorogenic acid, sakuranetin, isosakuranetin, syringenin 4-O-glucoside, syringenin 4-O-apiosyl-glucoside, alangilignoside C and ligalbumoside A compounds...
March 2018: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/29555410/viscum-articulatum-burm-f-aqueous-extract-exerts-antiproliferative-effect-and-induces-cell-cycle-arrest-and-apoptosis-in-leukemia-cells
#5
Ruchi Mishra, Saurabh Sharma, Radhey Shyam Sharma, Savita Singh, Milind Madhav Sardesai, Sadhna Sharma, Vandana Mishra
ETHNOPHARMACOLOGICAL RELEVANCE: Viscum articulatum Burm. f. (leafless mistletoe) has been used in traditional system of medicines in India, China, Taiwan, Cambodia, Laos, and Vietnam, to treat blood-related diseases and various inflammatory and degenerative diseases including cancer. Anticancer activities of some phytomolecules purified from Viscum articulatum Burm. f. have been tested. However scientific evidence for the anticancerous potential of aqueous extract of V. articularum (VAQE) used in traditional medicine is lacking...
March 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29495560/proteomic-methods-of-detection-and-quantification-of-protein-toxins
#6
REVIEW
Miloslava Duracova, Jana Klimentova, Alena Fucikova, Jiri Dresler
Biological toxins are a heterogeneous group of compounds that share commonalities with biological and chemical agents. Among them, protein toxins represent a considerable, diverse set. They cover a broad range of molecular weights from less than 1000 Da to more than 150 kDa. This review aims to compare conventional detection methods of protein toxins such as in vitro bioassays with proteomic methods, including immunoassays and mass spectrometry-based techniques and their combination. Special emphasis is given to toxins falling into a group of selected agents, according to the Centers for Disease Control and Prevention, such as Staphylococcal enterotoxins , Bacillus anthracis toxins, Clostridium botulinum toxins, Clostridium perfringens epsilon toxin, ricin from Ricinus communis , Abrin from Abrus precatorius or control of trade in dual-use items in the European Union, including lesser known protein toxins such as Viscumin from Viscum album ...
February 28, 2018: Toxins
https://www.readbyqxmd.com/read/29444603/safety-of-combined-treatment-with-monoclonal-antibodies-and-viscum-album-l-preparations
#7
Friedemann Schad, Jan Axtner, Matthias Kröz, Harald Matthes, Megan L Steele
Combination strategies involving chemotherapy and monoclonal antibodies (mAb) are commonly used in attempts to produce better clinical outcomes. This practice has led to new and ongoing toxicities that may lead to reductions in dose or noncompliance, limiting the effectiveness of treatment. Viscum album L (VA) preparations are widely used in Europe as additive therapy and have been associated with reduced chemotherapy-related adverse reactions and increased health-related quality of life. Concomitant VA therapy might also reduce toxicity related to mAb...
March 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29312767/minor-regression-and-long-time-survival-56-months-in-a-patient-with-malignant-pleural-mesothelioma-under-viscum-album-and-helleborus-niger-extracts-a-case-report
#8
Paul G Werthmann, Gerhard Saltzwedel, Gunver S Kienle
Malignant pleural mesothelioma (MPM) is a rare cancer with a dismal prognosis. Viscum album extracts (VAE) have strong immune stimulatory properties, cytotoxic effects, can downregulate cancer genes and inhibit angiogenesis. VAE are often used as an adjunct treatment in cancer patients but have rarely been investigated in MPM. Helleborus niger extracts (HNE) have been used in anticancer therapy since antiquity, and also show tumor specific cytotoxic effects. We present a case of a 64-year old woman with epithelioid MPM of the right chest with node involvement (T2N1M0, stage III)...
December 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29285722/determination-of-heavy-metals-in-almonds-and-mistletoe-as-a-parasite-growing-on-the-almond-tree-using-icp-oes-or-icp-ms
#9
Veysi Kamar, Rukiye Dağalp, Mustafa Taştekin
In this study, the elements of Al, As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, K, Mg, Mn, Mo, Ni, Sr, Pb, Ti, and Zn were determined in the leaves, fruits, and branches of mistletoe, (Viscum albüm L.), used as a medicinal plant, and in the leaves, branches and barks of almond tree which mistletoe grows on. The aim of the study is to investigate whether the mistletoe are more absorbent than the almond tree in terms of the heavy metal contents and the determination of the amount of the elements penetrated into the mistletoe from the almond tree...
December 28, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29241194/-kombinierte-anwendung-von-strahlentherapie-und-adjuvanter-therapie-mit-einem-mistelextrakt-viscum-album-l-zur-behandlung-des-oralen-malignen-melanoms-beim-hund-eine-retrospektive-studie
#10
Uta von Bodungen, Katja Ruess, Marcus Reif, Ulrike Biegel
Hintergrund: Orale maligne Melanome (OMM) des Hundes zeichnen sich durch schnelles Wachstum, lokale Invasion und hohe Metastasierungsraten aus. Extrakte auf Basis von Viscum album L. (VAE) werden zunehmend in der Krebstherapie sowohl in der Human- als auch in der Veterinärmedizin eingesetzt. Ziel unserer Studie war es zu untersuchen, inwieweit die adjuvante Therapie mit VAE eine therapeutische Option zur Behandlung von OMM ist. Besonderes Augenmerk galt dabei der Überlebenszeit und möglichen Nebenwirkungen...
2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/29237435/clinical-safety-of-combined-therapy-of-immune-checkpoint-inhibitors-and-viscum-album-l-therapy-in-patients-with-advanced-or-metastatic-cancer
#11
Anja Thronicke, Megan L Steele, Christian Grah, Burkhard Matthes, Friedemann Schad
BACKGROUND: Despite improvement of tumour response rates in patients with progressive and metastatic cancer, immune checkpoint inhibitors (ICM) induce toxicities in cancer patients. Viscum album L. (VA, mistletoe) extracts are applied as add-on cancer therapy especially in German speaking countries and within integrative and anthroposophical concepts with the goal to improve quality of life. The primary objective of this pilot observational cohort study was to determine the rate of adverse events (AE) related to ICM therapy with and without VA in patients with advanced or metastatic cancer in a certified Cancer Center...
December 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29237163/-postoperative-adjuvante-therapie-mit-einem-mistelextrakt-viscum-album-ssp-album-bei-h%C3%A3-ndinnen-mit-mammatumoren
#12
Ulrike Biegel, Nina Stratmann, Yvonne Knauf, Katja Ruess, Marcus Reif, Axel Wehrend
Hintergrund: Canine Mammatumoren (CMT) sind wegen ihrer Häufigkeit und hohen Malignitätsrate eine Herausforderung für die Veterinärmedizin. Bisher ist noch keine postoperative adjuvante Therapie als wirksamer Standard etabliert und in den nächsten Jahren wohl auch nicht zu erwarten. Zusätzlich ist die Frage nach der Verträglichkeit einer adjuvanten Therapie mit Erhaltung oder Verbesserung der Lebensqualität (LQ) wichtig. Die Therapie mit Mistelextrakten (Viscum album L.; VAE) ist in der Humanonkologie nach adjuvanter Tumorbasistherapie (Chemotherapie und Bestrahlung) eine sehr häufig verwendete, zusätzliche adjuvante Behandlungsmethode...
2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/29202738/effects-of-mistletoe-products-on-pharmacokinetic-drug-turnover-by-inhibition-and-induction-of-cytochrome-p450-activities
#13
Michael Schink, Oliver Dehus
BACKGROUND: European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe therapy. METHODS: Three European mistletoe products (Helixor® A, Helixor® M and Helixor® P from mistletoe grown on firs, apple trees and pines, respectively) were tested for inhibition of nine major cytochrome P450 (CYP) isoenzymes in a test system using pooled human liver microsomes and for induction of five CYP isoforms in human hepatocytes cultivated in vitro according to the relevant guideline...
December 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29190390/mistletoe-induced-growth-reductions-at-the-forest-stand-scale
#14
Chris Kollas, Martin Gutsch, Robert Hommel, Petra Lasch-Born, Felicitas Suckow
The hemiparasite European mistletoe (Viscum album L.) adversely affects growth and reproduction of the host Scots pine (Pinus sylvestris L.) and in consequence may lead to tree death. Here, we aimed to estimate mistletoe-induced losses in timber yield applying the process-based forest growth model 4C. The parasite was implemented into the eco-physiological forest growth model 4C using (literature-derived) established impacts of the parasite on the tree's water and carbon cycle. The amended model was validated simulating a sample forest stand in the Berlin area (Germany) comprising trees with and without mistletoe infection...
November 28, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29157828/immune-related-and-adverse-drug-reactions-to-low-versus-high-initial-doses-of-viscum-album-l-in-cancer-patients
#15
Friedemann Schad, Anja Thronicke, Antje Merkle, Harald Matthes, Megan L Steele
BACKGROUND: Immune-related adverse drug reactions (ADRs) to immunotherapy agents have been associated with beneficial clinical outcomes in oncology. Viscum album L. (VA, European mistletoe) is frequently used as an immunomodulatory agent alongside conventional cancer treatment in Europe. VA has been associated with improved quality of life and a reduction in chemotherapy-related ADRs. Beneficial effects of VA are believed to be related to its immunomodulatory properties. Current guidelines recommend commencing with a low dose and increasing slowly overtime, however, off-label prescribing of high initial doses is common...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157814/mistletoe-viscum-album-extract-targets-axl-to-suppress-cell-proliferation-and-overcome-cisplatin-and-erlotinib-resistance-in-non-small-cell-lung-cancer-cells
#16
Soyoung Kim, Kyung-Chan Kim, ChuHee Lee
BACKGROUND: Mistletoe extract of Visucm album extract (VAE) contains many biologically active components and has been reported to be not only a complementary and alternative medicine, but also a potent therapeutic agent for many types of cancer. PURPOSE: In this study, we examined the effect of VAE on expression and activation of Axl and scrutinized the involvement of Axl in the anti-cancer activity of VAE in parental and chemo-resistant non-small cell lung cancer (NSCLC) cells...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29145317/complete-remission-and-long-term-survival-of-a-patient-with-melanoma-metastases-treated-with-high-dose-fever-inducing-viscum-album-extract-a-case-report
#17
Paul G Werthmann, Alexander Hintze, Gunver S Kienle
INTRODUCTION: Metastatic malignant cutaneous melanoma (MCM)-a highly immunogenic cancer-typically has a poor prognosis. Viscum album extracts (VAEs) have strong immune-stimulating, apoptogenic, and cytotoxic effects. CASE PRESENTATION: A 66-year-old MCM patient with newly diagnosed lymph node metastases opted for sole VAE treatment. VAEs were initially applied subcutaneously, and then later in exceptionally high, fever-inducing doses, both intravenously and intralesionally...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29112983/identification-of-viscum-album-l-mirnas-and-prediction-of-their-medicinal-values
#18
Wenyan Xie, Jacob Adolf, Matthias F Melzig
MicroRNAs (miRNAs) are a class of approximately 22 nucleotides single-stranded non-coding RNA molecules that play crucial roles in gene expression. It has been reported that the plant miRNAs might enter mammalian bloodstream and have a functional role in human metabolism, indicating that miRNAs might be one of the hidden bioactive ingredients in medicinal plants. Viscum album L. (Loranthaceae, European mistletoe) has been widely used for the treatment of cancer and cardiovascular diseases, but its functional compounds have not been well characterized...
2017: PloS One
https://www.readbyqxmd.com/read/29095922/correction-viscum-album-neutralizes-tumor-induced-immunosuppression-in-a-human-in-vitro-cell-model
#19
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0181553.].
2017: PloS One
https://www.readbyqxmd.com/read/29034952/viscum-articulatum-burm-f-a-review-on-its-phytochemistry-pharmacology-and-traditional-uses
#20
REVIEW
Bhishma P Patel, Pawan K Singh
OBJECTIVES: The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. METHODS: Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords...
February 2018: Journal of Pharmacy and Pharmacology
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