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https://www.readbyqxmd.com/read/29202738/effects-of-mistletoe-products-on-pharmacokinetic-drug-turnover-by-inhibition-and-induction-of-cytochrome-p450-activities
#1
Michael Schink, Oliver Dehus
BACKGROUND: European mistletoe (Viscum album) products used in cancer therapy are frequently combined with other anti-cancer-drugs. Hence, potential herb-drug interactions have become a major safety concern in mistletoe therapy. METHODS: Three European mistletoe products (Helixor® A, Helixor® M and Helixor® P from mistletoe grown on firs, apple trees and pines, respectively) were tested for inhibition of nine major cytochrome P450 (CYP) isoenzymes in a test system using pooled human liver microsomes and for induction of five CYP isoforms in human hepatocytes cultivated in vitro according to the relevant guideline...
December 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29190390/mistletoe-induced-growth-reductions-at-the-forest-stand-scale
#2
Chris Kollas, Martin Gutsch, Robert Hommel, Petra Lasch-Born, Felicitas Suckow
The hemiparasite European mistletoe (Viscum album L.) adversely affects growth and reproduction of the host Scots pine (Pinus sylvestris L.) and in consequence may lead to tree death. Here, we aimed to estimate mistletoe-induced losses in timber yield applying the process-based forest growth model 4C. The parasite was implemented into the eco-physiological forest growth model 4C using (literature-derived) established impacts of the parasite on the tree's water and carbon cycle. The amended model was validated simulating a sample forest stand in the Berlin area (Germany) comprising trees with and without mistletoe infection...
November 28, 2017: Tree Physiology
https://www.readbyqxmd.com/read/29157828/immune-related-and-adverse-drug-reactions-to-low-versus-high-initial-doses-of-viscum-album-l-in-cancer-patients
#3
Friedemann Schad, Anja Thronicke, Antje Merkle, Harald Matthes, Megan L Steele
BACKGROUND: Immune-related adverse drug reactions (ADRs) to immunotherapy agents have been associated with beneficial clinical outcomes in oncology. Viscum album L. (VA, European mistletoe) is frequently used as an immunomodulatory agent alongside conventional cancer treatment in Europe. VA has been associated with improved quality of life and a reduction in chemotherapy-related ADRs. Beneficial effects of VA are believed to be related to its immunomodulatory properties. Current guidelines recommend commencing with a low dose and increasing slowly overtime, however, off-label prescribing of high initial doses is common...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157814/mistletoe-viscum-album-extract-targets-axl-to-suppress-cell-proliferation-and-overcome-cisplatin-and-erlotinib-resistance-in-non-small-cell-lung-cancer-cells
#4
Soyoung Kim, Kyung-Chan Kim, ChuHee Lee
BACKGROUND: Mistletoe extract of Visucm album extract (VAE) contains many biologically active components and has been reported to be not only a complementary and alternative medicine, but also a potent therapeutic agent for many types of cancer. PURPOSE: In this study, we examined the effect of VAE on expression and activation of Axl and scrutinized the involvement of Axl in the anti-cancer activity of VAE in parental and chemo-resistant non-small cell lung cancer (NSCLC) cells...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29145317/complete-remission-and-long-term-survival-of-a-patient-with-melanoma-metastases-treated-with-high-dose-fever-inducing-viscum-album-extract-a-case-report
#5
Paul G Werthmann, Alexander Hintze, Gunver S Kienle
INTRODUCTION: Metastatic malignant cutaneous melanoma (MCM)-a highly immunogenic cancer-typically has a poor prognosis. Viscum album extracts (VAEs) have strong immune-stimulating, apoptogenic, and cytotoxic effects. CASE PRESENTATION: A 66-year-old MCM patient with newly diagnosed lymph node metastases opted for sole VAE treatment. VAEs were initially applied subcutaneously, and then later in exceptionally high, fever-inducing doses, both intravenously and intralesionally...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29112983/identification-of-viscum-album-l-mirnas-and-prediction-of-their-medicinal-values
#6
Wenyan Xie, Jacob Adolf, Matthias F Melzig
MicroRNAs (miRNAs) are a class of approximately 22 nucleotides single-stranded non-coding RNA molecules that play crucial roles in gene expression. It has been reported that the plant miRNAs might enter mammalian bloodstream and have a functional role in human metabolism, indicating that miRNAs might be one of the hidden bioactive ingredients in medicinal plants. Viscum album L. (Loranthaceae, European mistletoe) has been widely used for the treatment of cancer and cardiovascular diseases, but its functional compounds have not been well characterized...
2017: PloS One
https://www.readbyqxmd.com/read/29095922/correction-viscum-album-neutralizes-tumor-induced-immunosuppression-in-a-human-in-vitro-cell-model
#7
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0181553.].
2017: PloS One
https://www.readbyqxmd.com/read/29034952/viscum-articulatum-burm-f-a-review-on-its-phytochemistry-pharmacology-and-traditional-uses
#8
REVIEW
Bhishma P Patel, Pawan K Singh
OBJECTIVES: The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. METHODS: Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords...
October 16, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28989251/a-hidden-treasure-the-borneo-mistletoes
#9
REVIEW
Ya Chee Lim, Rajan Rajabalaya, Sheba Rani David
The European mistletoe, Viscum album, is the most common consumed adjuvant among cancer patients in Europe. Its success warrants a report on three most apparent mistletoes found in Borneo Island, namely Scurrula ferruginea, Macrosolen cochinchinensis, and Dendrophthoe curvata. The traditional and pharmacological uses of these mistletoes include antibacterial, anticancer, antiviral, antihypertensive, antioxidative, and cytotoxic effects. Phytochemicals such as flavonols, alkaloids, tannins, and gallic acid have been reported in one of these mistletoes...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28795034/chemical-pleurodesis-using-doxycycline-and-viscum-album-extract
#10
Kyung Sub Song, DongYoon Keum, Jae Bum Kim
BACKGROUND: In chemical pleurodesis for managing pulmonary air leak, tetracycline derivatives are commonly used, and their effectiveness has been established in many studies. Recently, a Viscum album extract was used in chemical pleurodesis. We compared the effects of V. album with those of a tetracycline derivative (doxycycline) to demonstrate the therapeutic effectiveness of the V. album extract in chemical pleurodesis for managing pulmonary air leak. METHODS: Between October 2010 and October 2016, chemical pleurodesis was performed using doxycycline in 40 patients and the V...
August 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28791312/synergistic-antitumour-properties-of-viscumtt-in-alveolar-rhabdomyosarcoma
#11
Rahel Mascha Stammer, Susann Kleinsimon, Jana Rolff, Sebastian Jäger, Angelika Eggert, Georg Seifert, Catharina I Delebinski
Aqueous mistletoe extracts from the European mistletoe (Viscum album) contain mainly mistletoe lectins and viscotoxins as cytotoxic compounds. Lipophilic triterpene acids, which do not occur in conventional mistletoe preparations, were solubilised with β-cyclodextrins. The combination of an aqueous extract (viscum) and a triterpene-containing extract (TT) recreated a whole mistletoe extract (viscumTT). These extracts were tested on rhabdomyosarcoma in vitro, ex vivo, and in vivo with regard to anticancer effects...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28738255/simultaneous-identification-and-quantification-of-the-common-compounds-of-viscum-coloratum-and-its-corresponding-host-plants-by-ultra-high-performance-liquid-chromatography-with-quadrupole-time-of-flight-tandem-mass-spectrometry-and-triple-quadrupole-mass-spectrometry
#12
Cai Long, Ronghua Fan, Qili Zhang, Zhaoyan Zhang, Danlin Wang, Yingying Xia, Yuying Ma, Zhiguo Yu, Yunli Zhao
Viscum coloratum is a perennial evergreen, semi-parasitic plant. It is generally used for treating cardiovascular diseases, cancer, hepatitis and hemorrhage. In this study, reliable methods were developed for the qualitative and quantitative analysis of the common constituents in Viscum coloratum and its corresponding host. In the rapid qualitative analysis, a method of ultra-high performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry was established for identification of the same compounds...
September 1, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28719632/viscum-album-neutralizes-tumor-induced-immunosuppression-in-a-human-in-vitro-cell-model
#13
Carmen Steinborn, Amy Marisa Klemd, Ann-Sophie Sanchez-Campillo, Sophie Rieger, Marieke Scheffen, Barbara Sauer, Manuel Garcia-Käufer, Konrad Urech, Marie Follo, Annekathrin Ücker, Gunver Sophia Kienle, Roman Huber, Carsten Gründemann
Tumor cells have the capacity to secrete immunosuppressive substances in order to diminish dendritic cell (DC) activity and thereby escape from immune responses. The impact of mistletoe (Viscum album) extracts (VAE), which are frequently used as an additive anti-cancer therapy to stimulate the immune response, is still unknown. Using a human cellular system, the impact of two different VAE (VAEA + VAEI) on the maturation of human dendritic cells and on T cell function has been investigated using flow cytometry, automated fluorescence microscopy and cytokine bead array assays...
2017: PloS One
https://www.readbyqxmd.com/read/28689799/cardioprotective-effects-of-viscum-album-l-subsp-album-european-misletoe-leaf-extracts-in-myocardial-ischemia-and-reperfusion
#14
Eylem Suveren, Gary F Baxter, Alper B Iskit, Arzu Ucar Turker
ETHNOPHARMACOLOGICAL RELEVANCE: Viscum album L. (European mistletoe) is a hemiparasitic plant belonging to Loranthaceae family and has been used in Turkish traditional medicine for the treatment of cardiovascular disorders and heart diseases such as hypertension, tachycardia and angina pectoris. AIM OF THE STUDY: The present study investigated the cardioprotective effects of V. album leaf extracts in myocardial ischemia and reperfusion injury in rats. MATERIAL AND METHODS: Lyophilized aqueous (AVa) and methanolic (MVa) extracts of V...
July 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28676664/itraq-based-quantitative-proteomic-analysis-of-the-inhibitory-effects-of-polysaccharides-from-viscum-coloratum-kom-nakai-on-hepg2-cells
#15
Yangyang Chai, Min Zhao
Viscum coloratum (Kom.) Nakai is one of active medicinal plants, and its active components, especially polysaccharides, have been shown to exhibit bioactivity. In this study, we examined the effects of three polysaccharide fractions from Viscum coloratum (Kom.) Nakai on HepG2 cell growth in a dose-dependent manner by using a CCK-8 assay kit. Flow cytometry analysis showed that VCP2 treatment delayed the cell cycle in the G1 phase and induced apoptosis in HepG2 cells, a result possibly due to the increased expression of p21(Wafl/Cip1) and Cyclin D and the decreased expression of Cyclin E and CDK4...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28630419/iscador-qu-inhibits-doxorubicin-induced-senescence-of-mcf7-cells
#16
T Srdic-Rajic, J F Santibañez, K Kanjer, N Tisma-Miletic, M Cavic, D Galun, M Jevric, N Kardum, A Konic-Ristic, T Zoranovic
Chemotherapy in patients with inoperable or advanced breast cancer inevitably results in low-dose exposure of tumor-cell subset and senescence. Metabolically active senescent cells secrete multiple tumor promoting factors making their elimination a therapeutic priority. Viscum album is one of the most widely used alternative anti-cancer medicines facilitating chemotherapy tolerance of breast cancer patients. The aim of this study was to model and investigate how Viscum album extracts execute additive anti-tumor activity with low-dose Dox using ER + MCF7 breast cancer cells...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596809/viscum-album-l-in-experimental-animal-tumors-a-meta-analysis
#17
Leoni Villano Bonamin, Aloisio Cunha de Carvalho, Silvia Waisse
Mistletoe (Viscum album L.) has been used as complementary anticancer treatment for ~100 years. Although the clinical efficacy of mistletoe in cancer and associated survival benefits remain contested, several studies point to its effectiveness and others have reported antitumor and immunomodulatory properties. In the present review, a search was conducted for original articles reporting the outcomes of treatments for experimental animal tumors with mistletoe. The inclusion criteria were: Publication in English, from 1996 onwards and in peer-reviewed journals included in the database PubMed...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28571969/proteomic-fingerprinting-of-mistletoe-viscum-album-l-via-combinatorial-peptide-ligand-libraries-and-mass-spectrometry-analysis
#18
María Vergara-Barberán, María Jesús Lerma-García, Maria Nicoletti, Ernesto Francisco Simó-Alfonso, José Manuel Herrero-Martínez, Elisa Fasoli, Pier Giorgio Righetti
Combinatorial peptide ligand libraries (CPLLs), coupled to mass spectrometry (MS) analysis, have been used to investigate in depth the proteome of Viscum album L. (VA), commonly named European mistletoe, in order to provide a first proteomic fingerprinting. For this purpose, the proteins were captured via CPLLs at two different pH values (acidic and neutral). A total of 648 non-redundant proteins were identified by using two different databases. The two pH values, chosen for bead incubations, have contributed to increment the capture ability: 56% and 31% of CPLLs species were respectively recognized at pH7...
May 29, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28467981/-methotrexate-induced-nephrotoxicity-in-rats-protective-effect-of-mistletoe-viscum-album-l-extract
#19
Esin Sakalli Çetin, Hasan Tetiker, Özgür İlhan Çelik, Nigar Yılmaz, İbrahim Hakkı Ciğerci
No abstract text is available yet for this article.
May 4, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/28462133/effects-of-the-herb-mixture-dts20-on-oxidative-stress-and-plasma-alcoholic-metabolites-after-alcohol-consumption-in-healthy-young-men
#20
Yang Hee Hong
BACKGROUND: This study was designed to investigate the effect of a herbal mixture extract (DTS20) on the attenuation of oxidative stress and hangover after alcohol consumption in healthy volunteers. METHODS: DTS20 consists of Viscum album L. (40%), Lycium chinense L. (30%), Inonotus obliquus (20%), and Acanthopanax senticosus H. (10%). We recruited healthy, nonsmoking, adult men volunteers aged between 21 years and 30 years to participate in a crossover trial. Twenty participants received either one package of placebo with 200 mL water or DTS20 with 200 mL water...
December 2016: Integrative Medicine Research
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