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Won-Jae Lee

Do-Won Lee, Jae-Young Kwon, Hae-Kyu Kim, Hyeon-Jeong Lee, Eun-Soo Kim, Hyae-Jin Kim, Hyung-Joon Kim, Han-Bit Lee
Bone remodeling plays an important role in the bone healing process; for example, following fracture. The relative ratio of the receptor activator of nuclear factor kappa B ligand (RANKL)/ osteoprotegerin (OPG) controls osteoclast differentiation, thereby playing a pivotal role in the regulation of bone remodeling. Propofol, a widely used anesthetic agent in orthopedic procedures, is considered to possess potential antioxidant properties owing to its structural similarity to α-tocopherol. Antioxidants are known to enhance bone healing...
2018: International Journal of Medical Sciences
Seung-Shick Shin, Dae-Hwa Noh, Byungdoo Hwang, Jo-Won Lee, Sung Lyea Park, Sung-Soo Park, Bokyung Moon, Wun-Jae Kim, Sung-Kwon Moon
Background: Although the diverse biological properties of nanoparticles have been studied intensively, research into their mechanism of action is relatively rare. In this study, we investigated the molecular mechanisms of the anticancer activity of heterometallic Au@Pt-nanoseeds (NSs) against bladder cancers. Materials and methods: Mode of action of Au@Pt-NSs was investigated through MTT assay, flow cytometry analysis, Western immunoblots, real-time qPCR, wound-healing migration and invasion assays, zymography, and electrophoretic mobility shift assay (EMSA)...
2018: International Journal of Nanomedicine
Bo-Eun Kim, Soon Won Choi, Ji-Hee Shin, Jae-Jun Kim, Insung Kang, Byung-Chul Lee, Jin Young Lee, Myoung Geun Kook, Kyung-Sun Kang
Neural stem cells (NSCs) are a prominent cell source for understanding neural pathogenesis and for developing therapeutic applications to treat neurodegenerative disease because of their regenerative capacity and multipotency. Recently, a variety of cellular reprogramming technologies have been developed to facilitate in vitro generation of NSCs, called induced NSCs (iNSCs). However, the genetic safety aspects of established virus-based reprogramming methods have been considered, and non-integrating reprogramming methods have been developed...
January 1, 2018: Cell Transplantation
Byoung Yong Yoo, Byung Hwi Kim, Jae Sang Lee, Byung Ho Shin, Heeyeon Kwon, Won-Gun Koh, Chan Yeong Heo
In this study, we report a new physicochemical surface on poly(dimethylsiloxane) (PDMS)-based silicone implants in an effort to minimize capsular contracture. Two different surface modification strategies, namely, microtexturing as a physical cue and multilayer coating as a chemical cue, were combined to achieve synergistic effects. The deposition of uniformly sized microparticles onto uncured PDMS surfaces and the subsequent removal after curing generated microtextured surfaces with concave hemisphere micropatterns...
June 13, 2018: Acta Biomaterialia
Soon Sun Kim, Eun Kyoung Ahn, Soo Yeon Cho, Rae Woong Park, Hyo Jung Cho, Ji-Hyun Kim, Han Gyeol Kim, Ga Ram Lee, Sun Hyuk Hwang, Min Jae Yang, Jae Youn Cheong, Sung Won Cho
We evaluated whether nucleos(t)ide analog (NA) influences the risk of non-hepatocellular carcinoma (non-HCC) malignancies in patients with chronic hepatitis B (CHB). A total of 9867 patients with CHB were followed up for ≥12 months for the occurrence of any type of malignancy between 1998 and 2013. Patients who received NA for ≥180 days were defined as the NA group. Propensity score matching produced the control (n = 2220) and NA groups (n = 2220) after adjustment for age, sex, and the presence of diabetes mellitus and liver cirrhosis...
June 2018: Medicine (Baltimore)
Jae Ryong Shim, Sung-Sik Han, Hyung Min Park, Eung Chang Lee, Sang-Jae Park, Joong-Won Park
A bronchobiliary fistula, or a biliobronchial fistula (BBF), is a rare condition. It results from an abnormal connection between the biliary and bronchial trees, and is characterized by pathognomonic bilious sputum with suspicious pneumonia. Traditionally, an infectious disease, such as a hydatid infection, has been known to cause a BBF, but BBFs have recently become associated with tumors. In every case, procedures and treatments differ between centers, from simple conservative management to invasive surgical procedures...
May 2018: Annals of Hepato-Biliary-Pancreatic Surgery
So Hee Dho, Soo Yong Kim, Chaeuk Chung, Eun Ha Cho, So-Young Lee, Ji Young Kim, Lark Kyun Kim, Sung-Won Min, Jichul Lee, Sung Hee Jung, Jae Cheong Lim
Decay-accelerating factor (CD55 or DAF) inhibits complement-dependent cytotoxicity. We determined that CD55 is overexpressed in 76.47% of human non-small cell lung cancer tissue specimens. We therefore developed a lutetium-177-labeled chimeric monoclonal antibody against CD55. CD55-specific single-chain variable fragment (scFv) was selected from a naïve chicken scFv phage-display library, converted to IgG, and radiolabeled with lutetium-177 to generate a 177 Lu-anti-CD55 antibody. We then charaterized the biodistribution of this antibody in a mouse model of pleural metastatic lung cancer...
June 12, 2018: Scientific Reports
Byung-Chul Lee, Nari Shin, Jin Young Lee, Insung Kang, Jae-Jun Kim, Seung Eun Lee, Soon Won Choi, Gill A Webster, Kyung-Sun Kang
Human adult stem cells, including umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs), have recently been considered a promising alternative treatment for inflammatory bowel disease (IBD) due to their unique immunomodulatory properties and ability to promote tissue regeneration. However, despite many years of research and pre-clinical studies, results from clinical trials using these cells have been diverse and conflicting. This discrepancy is caused by several factors, such as poor engraftment, low survival rate, and donor-dependent variation of the cells...
2018: Frontiers in Immunology
Wan Beom Park, Kang Il Jun, Gayeon Kim, Jae-Phil Choi, Ji-Young Rhee, Shinhyea Cheon, Chang Hyun Lee, Jun-Sun Park, Yeonjae Kim, Joon-Sung Joh, Bum Sik Chin, Pyeong Gyun Choe, Ji Hwan Bang, Sang-Won Park, Nam Joong Kim, Dong-Gyun Lim, Yeon-Sook Kim, Myoung-Don Oh, Hyoung-Shik Shin
This nationwide, prospective cohort study evaluated pulmonary function and radiological sequelae according to infection severity in 73 survivors from the 2015 Middle East respiratory syndrome (MERS) outbreak in Korea. Patients with severe pneumonia in MERS-coronavirus infection had more impaired pulmonary function than those with no or mild pneumonia at the 1-year follow-up, which was compatible with the radiological sequelae. Severe pneumonia significantly impairs pulmonary function and makes long radiological sequelae in MERS...
June 11, 2018: Journal of Korean Medical Science
Ga Hee Kim, Ji Eun Won, Yeongseon Byeon, Min Gi Kim, Tae In Wi, Jae Myeong Lee, Yun-Yong Park, Jeong-Won Lee, Tae Heung Kang, In Duk Jung, Byung Cheol Shin, Hyung Jun Ahn, Young Joo Lee, Anil K Sood, Hee Dong Han, Yeong-Min Park
Angiogenesis plays an essential role in the growth and metastasis of tumor cells, and the modulation of angiogenesis can be an effective approach for cancer therapy. We focused on silencing the angiogenic gene PLXDC1 as an important factor for anti-angiogenesis tumor therapy. Herein, we developed PLXDC1 small interfering siRNA (siRNA)-incorporated chitosan nanoparticle (CH-NP/siRNA) coated with hyaluronic acid (HA) to target the CD44 receptor on tumor endothelial cells. This study aimed to improve targeted delivery and enhance therapeutic efficacy for tumor anti-angiogenesis...
November 2018: Drug Delivery
Hyun Nam, Ji-Hye Kim, Ji-Yoon Hwang, Gee-Hye Kim, Jae-Won Kim, Mi Jang, Jong-Ho Lee, Kyungpyo Park, Gene Lee
Patients with head and neck cancer are treated with therapeutic irradiation, which can result in irreversible salivary gland dysfunction. Because there is no complete cure for such patients, stem cell therapy is an emerging alternative for functional restoration of salivary glands. In this study, we investigated in vitro characteristics of primarily isolated epithelial cells from human salivary gland (Epi-SGs) and in vivo formation of acini-like structures by Epi-SGs. Primarily isolated Epi-SGs showed typical epithelial cell-like morphology and expressed E-cadherin but not N-cadherin...
June 11, 2018: Molecules and Cells
Ki-Bum Won, Donghee Han, Ji Hyun Lee, Sang-Eun Lee, Ji Min Sung, Su-Yeon Choi, Eun Ju Chun, Sung Hak Park, Hae-Won Han, Jidong Sung, Hae Ok Jung, Hyuk-Jae Chang
BACKGROUND: Data on the impact of optimal glycemic control (OGC) on the progression of coronary artery calcification, an important marker for future adverse cardiovascular events in individuals with diabetes are limited. METHODS: We investigated 1637 asymptomatic adults with diabetes (56 ± 8 years, 88.8% men) and no history of coronary artery disease or stroke, who underwent serial coronary artery calcium (CAC) screening. The median inter-scan period was 3...
September 1, 2018: International Journal of Cardiology
Woon-Jong Yu, Jae-Won Lee, Ngoc-Loi Nguyen, Sung-Keun Rhee, Soo-Je Park
Methanotrophic bacteria are widespread and use methane as a sole carbon and energy source. They also play a crucial role in marine ecosystems by preventing the escape of methane into the atmosphere from diverse methane sources, such as methane seeps and hydrothermal vents. Despite their importance for methane carbon cycling, relatively few marine methanotrophic bacteria have been isolated and studied at the genomic level. Herein, we report the genome of a marine methanotrophic member of the genus Methylomicrobium, metagenome-assembled genome (MAG) wino1, which was obtained through enrichment using methane as the sole carbon source...
May 29, 2018: Systematic and Applied Microbiology
Eun-Jae Lee, Jong S Kim, Dae-Il Chang, Jong-Ho Park, Seong Hwan Ahn, Jae-Kwan Cha, Ji Hoe Heo, Sung-Il Sohn, Byung-Chul Lee, Dong-Eog Kim, Hahn Young Kim, Seongheon Kim, Do-Young Kwon, Jei Kim, Woo-Keun Seo, Jun Lee, Sang-Won Park, Seong-Ho Koh, Jin Young Kim, Smi Choi-Kwon, Min-Sun Kim, Ji Sung Lee
BACKGROUND AND PURPOSE: The pathophysiology of post-stroke depression (PSD) is complex and may differ according to an individual's mood immediately after stroke. Here, we compared the therapeutic response and clinical characteristics of PSD at a later stage between patients with and without depression immediately after stroke. METHODS: This study involved a post hoc analysis of data from EMOTION ( NCT01278498), a placebo-controlled, double-blind trial that examined the efficacy of escitalopram (10 mg/day) on PSD and other emotional disturbances among 478 patients with acute stroke...
May 2018: Journal of Stroke
Jaemyeong Shin, Yun Jeong Kim, Jong Kun Kim, Dong Eun Lee, Sungbae Moon, Jae Young Choe, Won Kee Lee, Hyung Min Lee, Kwang Hyun Cho
OBJECTIVES: Early retirement occurs when one's job satisfaction suffers due to employment mismatch resulting from factors such as inadequate compensation. Medical doctors report high levels of job stress and burnout relative to other professionals. These levels are highest among emergency physicians (EPs), and despite general improvements in their working conditions, early retirement continues to become more common in this population. The purpose of this study was to identify the factors influencing EPs intention to retire early and to develop a probability equation for its prediction...
May 2018: Journal of Preventive Medicine and Public Health, Yebang Ŭihakhoe Chi
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
June 7, 2018: Scientific Reports
Byeong Geun Song, Yang Won Min, Ra Ri Cha, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Jae J Kim
BACKGROUND: Endoscopic submucosal dissection (ESD) has been widely accepted for treating superficial esophageal squamous cell carcinoma (SESCC). The aim of this study was to evaluate the efficacy and safety of ESD for SESCC and the effect of different sedation methods on their clinical outcomes. METHODS: We retrospectively analyzed a total of 169 patients (175 lesions) who underwent ESD for SESCC at Samsung Medical Center, Seoul, South Korea. Short-term and long-term clinical outcomes were evaluated and compared according to the sedation method (conscious sedation [CS] vs general anesthesia [GA])...
June 7, 2018: BMC Gastroenterology
Miso Lee, Kyung-Hun Lee, Ahrum Min, Jeongeun Kim, Seongyeong Kim, Hyemin Jang, Jee Min Lim, So Hyeon Kim, Dong-Hyeon Ha, Won Jae Jeong, Koung Jin Suh, Yae-Won Yang, Tae Yong Kim, Do-Youn Oh, Yung-Jue Bang, Seock-Ah Im
Purpose: Pim kinases are highly conserved serine/threonine kinases, and different expression patterns of each isoform (Pim-1, Pim-2, and Pim-3) have been observed in various types of human cancers, including gastric cancer. AZD1208 is a potent and selective inhibitor that affects all three isoforms of Pim. We investigated the effects of AZD1208 as a single agent and in combination with an Akt inhibitor in gastric cancer cells. Materials and Methods: The antitumor activity of AZD1208 with/without an Akt inhibitor was evaluated in a large panel of gastric cancer cell lines through growth inhibition assays...
June 6, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Jae-A Lim, Soo-Hee Choi, Won Joon Lee, Joon Hwan Jang, Jee Youn Moon, Yong Chul Kim, Do-Hyung Kang
Chronic pain is defined as persistent or recurrent pain lasting longer than 3 months; the severity of pain can be rated in terms of intensity, pain-related distress, and functional impairment. Researches have shown an association between psychosocial factors, such as empathic ability, and the severity of pain. Cognitive-behavioral therapy (CBT) is the most common psychologic intervention for individuals with chronic pain. The aim of this study was to investigate the effect of CBT on empathy in chronic pain patients, examining especially gender differences...
June 2018: Medicine (Baltimore)
Sang-Cheol Bae, Soo-Kyung Cho, Soyoung Won, Hye-Soon Lee, Sang-Heon Lee, Young Mo Kang, Sang-Hoon Lee, Yeon-Ah Lee, Jung-Yoon Choe, Won-Tae Chung, Chang-Hee Suh, Seung-Cheol Shim, Jisoo Lee, Bo Young Yoon, Dong-Wook Kim, Shin-Seok Lee, Wan-Hee Yoo, Jin-Seok Kim, Young-Ok Jung, Seong-Su Nah, Choong-Ki Lee, Gwan-Gyu Song, Sung Jae Choi, Chung-Il Joung, Hyein Koh, Young-Joo Kim
AIM: To determine characteristics of rheumatoid arthritis (RA) patients in Korea using disease-modifying anti-rheumatic drugs (DMARDs) for at least 6 months, and to identify factors associated with poor health-related outcomes. METHOD: A total of 2000 RA patients aged > 20 years, treated with DMARDs for at least 6 months, and signed informed consent, were enrolled in this non-interventional, multicenter, cross-sectional observational study from December 2012 to June 2013...
May 2018: International Journal of Rheumatic Diseases
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