keyword
https://read.qxmd.com/read/38547066/a-wireless-implantable-bioelectronic-system-for-monitoring-urinary-bladder-function-following-surgical-recovery
#1
JOURNAL ARTICLE
Jihye Kim, Matthew I Bury, Kyeongha Kwon, Jae-Young Yoo, Nadia V Halstead, Hee-Sup Shin, Shupeng Li, Sang Min Won, Min-Ho Seo, Yunyun Wu, Do Yun Park, Mitali Kini, Jean Won Kwak, Surabhi R Madhvapathy, Joanna L Ciatti, Jae Hee Lee, Suyeon Kim, Hanjun Ryu, Kento Yamagishi, Hong-Joon Yoon, Sung Soo Kwak, Bosung Kim, Yonggang Huang, Lisa C Halliday, Earl Y Cheng, Guillermo A Ameer, Arun K Sharma, John A Rogers
Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38547061/the-%C3%AE-2-adrenergic-receptor-associates-with-cxcr4-multimers-in-human-cancer-cells
#2
JOURNAL ARTICLE
Junyi Liang, Mohamed Seghiri, Pradeep Kumar Singh, Hyeon Gyu Seo, Ji Yeong Lee, Yoonjung Jo, Yong Bhum Song, Chulo Park, Piotr Zalicki, Jae-Yeon Jeong, Won-Ki Huh, Niña G Caculitan, Adam W Smith
While the existence and functional role of class C G-protein-coupled receptors (GPCR) dimers is well established, there is still a lack of consensus regarding class A and B GPCR multimerization. This lack of consensus is largely due to the inherent challenges of demonstrating the presence of multimeric receptor complexes in a physiologically relevant cellular context. The C-X-C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer therapy. Here, we investigated the potential of CXCR4 to form multimeric complexes with other GPCRs and characterized the relative size of the complexes in a live-cell environment...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38546645/reduced-alcohol-consumption-and-major-adverse-cardiovascular-events-among-individuals-with-previously-high-alcohol-consumption
#3
JOURNAL ARTICLE
Dong Oh Kang, Dae-In Lee, Seung-Young Roh, Jin Oh Na, Cheol Ung Choi, Jin Won Kim, Eung Ju Kim, Seung-Woon Rha, Chang Gyu Park, Ye-Seul Kim, Yonghwan Kim, Hyo-Sun You, Hee-Taik Kang, Eunseo Jo, Jinseob Kim, Jae-Woo Lee, Jin-Man Jung
IMPORTANCE: Cardiovascular benefits of mild to moderate alcohol consumption need to be validated in the context of behavioral changes. The benefits of reduced alcohol consumption among people who drink heavily across different subtypes of cardiovascular disease (CVD) are unclear. OBJECTIVE: To investigate the association between reduced alcohol consumption and risk of major adverse cardiovascular events (MACEs) in individuals who drink heavily across different CVD subtypes...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38545995/probing-local-ph-change-during-electrode-oxidation-of-tempo-derivative-implication-of-redox-induced-acidity-alternation-by-imidazolium-linker-functional-groups
#4
JOURNAL ARTICLE
Jeongmin Yeo, Kyungmi Kim, Seung Jae Kwak, Mi Song Kim, Jung Hoon Yang, Won Bo Lee, YongJoo Kim, Junghyun Chae, Jinho Chang
The chemical degradation of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-based aqueous energy storage and catalytic systems is pH sensitive. Herein, we voltammetrically monitor the local pH (pHlocal ) at a Pt ultramicroelectrode (UME) upon electro-oxidation of imidazolium-linker functionalized TEMPO and show that its decrease is associated with the greater acidity of the cationic (oxidized) rather than radical (reduced) form of TEMPO. The protons that drive the decrease in pH arise from hydrolysis of the conjugated imidazolium-linker functional group of 4-[2-( N -methylimidazolium)acetoxy]-2,2,6,6-tetramethylpiperidine-1-oxyl chloride (MIMAcO-T), which was studied in comparison with 4-hydroxyl-TEMPO (4-OH-T)...
March 28, 2024: Analytical Chemistry
https://read.qxmd.com/read/38545884/changes-in-otitis-media-during-covid-19
#5
JOURNAL ARTICLE
Yongmin Cho, Jong-Geun Lee, Gi Hwan Ryu, Jae-Jun Song, Gi Jung Im, Sung-Won Chae
OBJECTIVES: During the COVID-19 pandemic, various non-pharmaceutical interventions such as individual hygiene practices like hand washing, social distancing, and mandates for the use of masks in public spaces were implemented to reduce the spread of the disease. Otitis media (OM) is a common infectious disease. How the changed environment due to the COVID-19 pandemic has influenced the prevalence of infectious diseases like OM is not known. This study aimed to investigate how OM prevalence and trends changed during COVID-19 in Korea...
March 28, 2024: Annals of Otology, Rhinology, and Laryngology
https://read.qxmd.com/read/38542291/unveiling-prognostic-rna-biomarkers-through-a-multi-cohort-study-in-colorectal-cancer
#6
JOURNAL ARTICLE
Zehwan Kim, Jaebon Lee, Ye Eun Yoon, Jae Won Yun
Because cancer is a leading cause of death and is thought to be caused by genetic errors or genomic instability in many circumstances, there have been studies exploring cancer's genetic basis using microarray and RNA-seq methods, linking gene expression data to patient survival. This research introduces a methodological framework, combining heterogeneous gene expression data, random forest selection, and pathway analysis, alongside clinical information and Cox regression analysis, to discover prognostic biomarkers...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541958/evaluation-of-the-fusion-rate-and-safety-of-escherichia-coli-derived-rhbmp-2-in-transforaminal-lumbar-interbody-fusion-for-patients-with-degenerative-lumbar-disease-a-prospective-multicenter-single-arm-trial
#7
JOURNAL ARTICLE
Ji-Won Kwon, Jae Hwan Cho, Jong Beom Lee, Jae Hong Kim
Background: Few studies have documented the viability of E. coli -derived recombinant human bone morphogenetic protein-2 (rhBMP-2) in transforaminal lumbar interbody fusion (TLIF). This study aimed to assess the safety and fusion rate of rhBMP-2 in TLIF. Methods: The study was conducted as a prospective, multicenter, single-arm trial, and 30 patients needing one- or two-level TLIF were enrolled. Fusion rate was assessed using the 12-month interbody fusion rate on CT. Postoperative problems, including seroma, radiculitis, and ectopic bone formation, which have been documented as risks associated with rhBMP-2 in prior studies, were recorded...
March 17, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541832/the-outcomes-of-mini-plate-fixation-for-unstable-wagstaffe-tubercle-fracture-an-indirect-syndesmosis-injury-in-rotational-ankle-fracture
#8
JOURNAL ARTICLE
Byung-Ryul Lee, Ki-Jin Jung, Eui-Dong Yeo, Sung-Hun Won, Yong-Cheol Hong, Chang-Hwa Hong, Chang-Hyun Kim, Ho-Sung Kim, Jae-Young Ji, Je-Yeon Byeon, Dhong-Won Lee, Woo-Jong Kim
Background: Wagstaffe fracture constitutes an indirect injury to the AITFL and can precipitate syndesmotic instability. The prevailing fixation methods often involve the use of mini-screws or K-wires, with absorbable suture repair reserved for cases with small or comminuted fragments exhibiting instability. In this study, we devised a mini-plate fixation method capable of securing the fracture fragment irrespective of its size or condition. Methods: A retrospective chart review was conducted on patients who underwent surgery for ankle fractures between May 2022 and October 2023...
March 11, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38534086/unstable-vancouver-b1-periprosthetic-femoral-fracture-fixation-a-biomechanical-comparison-between-a-novel-c-shaped-memory-alloy-implant-and-cerclage-wiring
#9
JOURNAL ARTICLE
Seog-Hyun Oh, Yu-Sung Suh, Emmanuel Eghan-Acquah, Kollerov Mikhail Yurevich, Sung-Hun Won, Min Jung Baek, Sung-Jae Lee, Sung-Woo Choi
BACKGROUND: To compare the biomechanical stability of a novel, C-shaped nickel-titanium shape memory alloy (SMA) implant (C-clip) with traditional cerclage wiring in the fixation of a Vancouver B1 (VB1) periprosthetic femoral fracture (PFF). METHODS: In total, 18 synthetic femoral fracture models were constructed to obtain unstable VB1 fracture with an oblique fracture line 8 cm below the lesser trochanter. For each model, the distal portion was repaired using a 10-hole locking plate and four distal bi-cortical screws...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38532823/corrigendum-to-development-and-asian-wide-validation-of-the-grade-for-interpretable-field-triage-gift-for-predicting-mortality-in-pre-hospital-patients-using-the-pan-asian-trauma%C3%A2-outcomes-study-patos-the-lancet-regional-health-western-pacific-34-2023-100733
#10
Jae Yong Yu, Sejin Heo, Feng Xie, Nan Liu, Sun Yung Yoon, Han Sol Chang, Taerim Kim, Se Uk Lee, Marcus Eng Hock Ong, Yih Yng Ng, Sang Do Shin, Kentaro Kajino, Wen-Chu Chiang, Won Chul Cha
[This corrects the article DOI: 10.1016/j.lanwpc.2023.100733.].
March 2024: The Lancet Regional Health. Western Pacific
https://read.qxmd.com/read/38532472/association-between-genetic-risk-and-adherence-to-healthy-lifestyle-for-developing-age-related-hearing-loss
#11
JOURNAL ARTICLE
Sang-Hyuk Jung, Young Chan Lee, Manu Shivakumar, Jaeyoung Kim, Jae-Seung Yun, Woong-Yang Park, Hong-Hee Won, Dokyoon Kim
BACKGROUND: Previous studies have shown that lifestyle/environmental factors could accelerate the development of age-related hearing loss (ARHL). However, there has not yet been a study investigating the joint association among genetics, lifestyle/environmental factors, and adherence to healthy lifestyle for risk of ARHL. We aimed to assess the association between ARHL genetic variants, lifestyle/environmental factors, and adherence to healthy lifestyle as pertains to risk of ARHL. METHODS: This case-control study included 376,464 European individuals aged 40 to 69 years, enrolled between 2006 and 2010 in the UK Biobank (UKBB)...
March 26, 2024: BMC Medicine
https://read.qxmd.com/read/38529692/prenatal-and-postnatal-exposure-to-antibiotics-and-risk-of-food-allergy-in-the-offspring-a-nationwide-birth-cohort-study-in-south-korea
#12
JOURNAL ARTICLE
Jiyeon Oh, Myeongcheol Lee, Jaeyu Park, Hyeon Jin Kim, Seung Won Lee, Masoud Rahmati, Ai Koyanagi, Lee Smith, Min Seo Kim, Guillermo F López Sánchez, Elena Dragioti, Chanyang Min, Nikolaos G Papadopoulos, Youn Ho Shin, Jae Il Shin, Dong Keon Yon
BACKGROUND: There are only preliminary studies examining the associations of postnatal antibiotic exposure with food allergy in childhood, and the effect of antibiotic exposure in utero has not been resolved. Thus, we aimed to investigate the effect of prenatal and postnatal antibiotic exposure on the risk of food allergy in childhood. METHODS: Using the nationwide birth cohort in South Korea, all 3,163,206 infants (pairing mother; n = 2,322,735) born in South Korea between 2010 and 2017 were included in the analysis...
March 2024: Pediatric Allergy and Immunology
https://read.qxmd.com/read/38528385/predicting-the-outcome-of-pediatric-oral-food-challenges-for-determining-tolerance-development
#13
JOURNAL ARTICLE
Hamin Kim, Kyunguk Jeong, Mireu Park, Yun Young Roh, Jae Hwa Jung, Soo Yeon Kim, Jong Deok Kim, Min Jung Kim, Yoon Hee Kim, Myung Hyun Sohn, Sooyoung Lee, Kyung Won Kim
PURPOSE: Despite the risk of anaphylaxis, oral food challenges (OFCs) are performed clinically for various indications, particularly to confirm tolerance development. This study aimed to assess OFCs by relevant indications and build an outcome prediction model to help determine when to perform OFCs in children who are likely to have developed immune tolerance. METHODS: In total, 432 pediatric OFCs were retrospectively analyzed according to indications. Clinical characteristics, serum total immunoglobulin (Ig) E, blood eosinophils, and specific IgE and IgG4 levels for food allergens were noted and compared...
March 2024: Allergy, Asthma & Immunology Research
https://read.qxmd.com/read/38528103/dynamic-three-dimensional-structures-of-a-metal-organic-framework-captured-with-femtosecond-serial-crystallography
#14
JOURNAL ARTICLE
Jaedong Kang, Yunbeom Lee, Seonggon Lee, Hosung Ki, Jungmin Kim, Jain Gu, Yongjun Cha, Jun Heo, Kyung Won Lee, Seong Ok Kim, Jaehyun Park, Sang-Youn Park, Sangsoo Kim, Rory Ma, Intae Eom, Minseok Kim, Jeongho Kim, Jae Hyuk Lee, Hyotcherl Ihee
Crystalline systems consisting of small-molecule building blocks have emerged as promising materials with diverse applications. It is of great importance to characterize not only their static structures but also the conversion of their structures in response to external stimuli. Femtosecond time-resolved crystallography has the potential to probe the real-time dynamics of structural transitions, but, thus far, this has not been realized for chemical reactions in non-biological crystals. In this study, we applied time-resolved serial femtosecond crystallography (TR-SFX), a powerful technique for visualizing protein structural dynamics, to a metal-organic framework, consisting of Fe porphyrins and hexazirconium nodes, and elucidated its structural dynamics...
March 25, 2024: Nature Chemistry
https://read.qxmd.com/read/38527637/physical-activity-and-prevention-of-mental-health-complications-an-umbrella-review
#15
REVIEW
Masoud Rahmati, San Lee, Dong Keon Yon, Seung Won Lee, Raphael Udeh, Mark McEvoy, Hans Oh, Laurie Butler, Helen Keyes, Yvonne Barnett, Ai Koyanagi, Jae Il Shin, Lee Smith
The potential of physical activity in preventing mental health issues has garnered interest among health professionals. We conducted a systematic umbrella review of evidence supporting the relationship between physical activity and the prevention of mental health complications. Our findings revealed a significant association between higher physical activity levels and reduced risk of depression (OR = 0.77, 95% CI 0.72 - 0.82). This association was consistent across various age groups, sex, and geographical regions...
March 23, 2024: Neuroscience and Biobehavioral Reviews
https://read.qxmd.com/read/38526569/the-beneficial-roles-of-sargassum-spp-in-skin-disorders
#16
JOURNAL ARTICLE
Min-Kyeong Lee, Hyeon Hak Jeong, Myeong-Jin Kim, Jae Seong Seo, Ji Young Hwang, Won-Kyo Jung, Kyoung Mi Moon, Incheol Lee, Bonggi Lee
As the body's largest organ, the skin is located at the internal and external environment interface, serving as a line of defense against various harmful stressors. Recently, marine-derived physiologically active ingredients have attracted considerable attention in the cosmeceutical industry due to their beneficial effects on skin health. Sargassum , a genus of brown macroalgae, has traditionally been consumed as food and medicine in several countries and is rich in bioactive compounds such as meroterpenoids, sulfated polysaccharides, fucoidan, fucoxanthin, flavonoids, and terpenoids...
March 22, 2024: Journal of Medicinal Food
https://read.qxmd.com/read/38525995/epidemiology-and-treatment-outcome-of-anca-associated-vasculitis-in-south-korea-a-nationwide-population-based-cohort-study
#17
JOURNAL ARTICLE
Jun Won Park, Jihun Song, Seulggie Choi, Sun Jae Park, Sang Min Park, Eun Young Lee
OBJECTIVES: To investigate the epidemiological features of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in South Korea. METHODS: We identified the index cases of GPA and MPA using the 2010-2018 Korean National Health Insurance Service database and the Rare Intractable Disease registry for the entire Korean population. Each disease's incidence and prevalence rates and trends over time were analysed. To assess the impact of disease on morbidity and mortality, a comparator group comprising the general population was established using nearest-neighbour matching by age, sex, income, and comorbidity index, at a 5:1 ratio...
March 25, 2024: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/38522853/comparison-of-the-clinical-outcomes-of-esophagectomy-and-concurrent-chemoradiotherapy-in-patients-with-locally-advanced-esophageal-squamous-cell-carcinoma
#18
JOURNAL ARTICLE
Myung Hun Lee, Moo In Park, Ju Won Lee, Kyoungwon Jung, Jae Hyun Kim, Sung Eun Kim, Won Moon, Seun Ja Park
BACKGROUND/AIMS: The efficacy of concurrent chemoradiotherapy (CCRT) or esophagectomy for locally advanced esophageal squamous cell carcinoma (ESCC) is unclear. This study compared the survival and recurrence of patients with locally advanced ESCC after definitive CCRT and surgery. METHODS: A retrospective study was conducted on patients with locally advanced ESCC who underwent CCRT or esophagectomy at Kosin University Gospel Hospital from January 2010 to December 2016...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38520060/highly-efficient-room-temperature-spin-orbit-torque-switching-in-a-van-der-waals-heterostructure-of-topological-insulator-and-ferromagnet
#19
JOURNAL ARTICLE
Gyu Seung Choi, Sungyu Park, Eun-Su An, Juhong Bae, Inseob Shin, Beom Tak Kang, Choong Jae Won, Sang-Wook Cheong, Hyun-Woo Lee, Gil-Ho Lee, Won Joon Cho, Jun Sung Kim
All-Van der Waals (vdW)-material-based heterostructures with atomically sharp interfaces offer a versatile platform for high-performing spintronic functionalities at room temperature. One of the key components is vdW topological insulators (TIs), which can produce a strong spin-orbit-torque (SOT) through the spin-momentum locking of their topological surface state (TSS). However, the relatively low conductance of the TSS introduces a current leakage problem through the bulk states of the TI or the adjacent ferromagnetic metal layers, reducing the interfacial charge-to-spin conversion efficiency (qICS )...
March 22, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38519550/three-new-phthalide-derivatives-from-culture-broth-of-dentipellis-fragilis-and-their-cytotoxic-activities
#20
JOURNAL ARTICLE
Dae-Won Ki, Dae-Cheol Choi, Yeong-Seon Won, Seung-Jae Lee, Young-Hee Kim, In-Kyoung Lee, Bong-Sik Yun
Three new phthalide derivatives (1‒3) together with two known compounds, erinaceolactone B (4) and hericerin III (5), were isolated from the culture broth of Dentipellis fragilis. The chemical structures of 1‒5 were determined by analyses of their 1D-, 2D-NMR, and MS. The absolute configuration of 1 was determined by CD analysis. The isolated compounds were assessed for their cytotoxic activities against A549, DU145, HCT116, and HT1080 cancer cell lines. Compounds 1‒5 showed strong cytotoxic activities against DU145, with IC50 values ranging from 14...
March 22, 2024: Journal of Antibiotics
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