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https://www.readbyqxmd.com/read/29244617/differentiation-of-high-grade-from-low-grade-astrocytoma-improvement-in-diagnostic-accuracy-and-reliability-of-pharmacokinetic-parameters-from-dce-mr-imaging-by-using-arterial-input-functions-obtained-from-dsc-mr-imaging
#1
Sung-Hye You, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Sung-Hye Park, Jae-Kyung Won, Il Han Kim, Soon Tae Lee, Hye Jeong Choi, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Purpose To evaluate whether arterial input functions (AIFs) derived from dynamic susceptibility-contrast (DSC) magnetic resonance (MR) imaging, or AIFDSC values, improve diagnostic accuracy and reliability of the pharmacokinetic (PK) parameters of dynamic contrast material-enhanced (DCE) MR imaging for differentiating high-grade from low-grade astrocytomas, compared with AIFs obtained from DCE MR imaging (AIFDCE). Materials and Methods This retrospective study included 226 patients (138 men, 88 women; mean age, 52...
December 15, 2017: Radiology
https://www.readbyqxmd.com/read/29243195/indication-for-endoscopic-treatment-based-on-the-risk-of-lymph-node-metastasis-in-patients-with-siewert-type-ii-iii-early-gastric-cancer
#2
Jeung Hui Pyo, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Kyoung-Mee Kim, Heejin Yoo, Soohyun Ahn, Jae J Kim
BACKGROUND: Because of the poor prognosis of proximal gastric cancers, there is debate as to whether the conventional indications for endoscopic resection can be used. METHODS: Among subjects who underwent surgery for esophagogastric junction or gastric cardia cancer, 256 patients with T1 type II/III of the Siewert classification were included in this study. The association of lymph node metastasis (LNM) with each variable was analyzed using logistic regression models...
December 14, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29243057/decreased-muscle-mass-is-independently-associated-with-knee-pain-in-female-patients-with-radiographically-mild-osteoarthritis-a-nationwide-cross-sectional-study-knhanes-2010-2011
#3
Hee Min Park, Ho Jae Kim, Byeori Lee, Minkyoung Kwon, Seung Min Jung, Sang-Won Lee, Yong-Beom Park, Jason Jungsik Song
To evaluate the association between muscle mass and knee pain in relation to radiographic severity of knee osteoarthritis. We consulted nationwide health examination and survey records collected from 2010 to 2011 and extracted data regarding female patients aged > 50 years and diagnosed with knee osteoarthritis. Radiographic severity was assessed on plain radiographs using the Kellgren-Lawrence system, whereas appendicular skeletal mass was obtained from dual-energy X-ray absorptiometry data. We performed multivariate logistic regression to evaluate the association between knee pain and muscle mass index (appendicular skeletal muscle mass divided by body weight in percentile) in patient groups stratified by radiographic severity of knee osteoarthritis...
December 14, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29239729/corrigendum-to-anti-inflammatory-effects-of-perillae-herba-ethanolic-extract-against-tnf-%C3%AE-ifn-%C3%AE-stimulated-human-keratinocyte-hacat-cells-j-ethnopharmacol-211-2018-217-223
#4
Ju-Hye Yang, Jae-Myung Yoo, Esther Lee, BoHyoung Lee, Won-Kyung Cho, Kwang-Il Park, Jin Yeul Ma
No abstract text is available yet for this article.
November 24, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29238036/identification-of-additional-ehmt2-variant-associated-with-the-risk-of-chronic-hepatitis-b-by-gwas-follow-up-study
#5
Joong-Gon Shin, Hyun Sub Cheong, Jason Yongha Kim, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Jae Youn Cheong, Sung Won Cho, Neung Hwa Park, Suhg Namgoong, Lyoung Hyo Kim, Yoon Jun Kim, Hyoung Doo Shin
Chronic hepatitis B (CHB) is a precursor to liver cirrhosis and hepatocellular carcinoma, caused by a Hepatitis B viral infection. Genome-wide association studies (GWASs) have been conducted to find genes associated with CHB risk. In previous GWAS, EHMT2 was identified as one of the susceptibility genes for CHB. To further characterize this association and discover possible causal variants, we conducted an additional association study. A total of 11 EHMT2 single-nucleotide polymorphisms (SNP) were selected and genotyped in 3902 subjects (1046 CHB patients and 2856 controls)...
December 14, 2017: Genes and Immunity
https://www.readbyqxmd.com/read/29233531/genomic-landscape-of-ovarian-clear-cell-carcinoma-via-whole-exome-sequencing
#6
Se Ik Kim, Ji Won Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song, Jeong-Sun Seo
OBJECTIVE: To analyze whole exome sequencing (WES) data on ovarian clear cell carcinoma (OCCC) in Korean patients via the technique of next generation sequencing (NGS). Genomic profiles were compared between endometriosis-associated OCCC (EMS-OCCC) and Non-EMS-OCCC. METHODS: We used serum samples and cancer tissues, stored at the Seoul National University Hospital Human Biobank, that were initially collected from women diagnosed with OCCC between 2012 and 2016. In total, 15 patients were enrolled: 5 with pathologically confirmed EMS-OCCC and 10 with Non-EMS-OCCC...
December 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29233096/evaluation-of-scoring-systems-without-endoscopic-findings-for-predicting-outcomes-in-patients-with-upper-gastrointestinal-bleeding
#7
Il-Gyu Ko, Sung-Eun Kim, Bok Soon Chang, Min Seob Kwak, Jin Young Yoon, Jae Myung Cha, Hyun Phil Shin, Joung Il Lee, Sang Hyun Kim, Jin Hee Han, Jung Won Jeon
BACKGROUND: Risk scoring systems are used to evaluate patients with upper gastrointestinal bleeding (UGIB). We compared Glasgow-Blatchford score (GBS), modified GBS (mGBS), and Pre-endoscopy Rockall score (Pre-E RS) for immediate application without endoscopic findings in predicting the need of interventions and the 30-day mortality in patients with UGIB. METHODS: Patients who visited the emergency room with UGIB from January 2007 to June 2016 were included. GBS, mGBS, and Pre-E RS were obtained for all patients...
December 12, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29232940/no-benefit-of-hypomethylating-agents-compared-to-supportive-care-for-higher-risk-myelodysplastic-syndrome
#8
Sang Kyun Sohn, Joon Ho Moon, In Hee Lee, Jae Sook Ahn, Hyeoung Joon Kim, Joo Seop Chung, Ho Jin Shin, Sung Woo Park, Won Sik Lee, Sang Min Lee, Hawk Kim, Ho Sup Lee, Yang Soo Kim, Yoon Young Cho, Sung Hwa Bae, Ji Hyun Lee, Sung Hyun Kim, Ik Chan Song, Ji Hyun Kwon, Yoo Jin Lee
Background/Aims: This study evaluated the role of hypomethylating agents (HMA) compared to best supportive care (BSC) for patients with high or very-high (H/VH) risk myelodysplastic syndrome (MDS) according to the Revised International Prognostic Scoring System. Methods: A total of 279 H/VH risk MDS patients registered in the Korean MDS Working Party database were retrospectively analyzed. Results: HMA therapy was administered to 205 patients (73...
December 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29232938/factors-associated-with-time-to-diagnosis-from-symptom-onset-in-patients-with-early-rheumatoid-arthritis
#9
Soo-Kyoung Cho, Dam Kim, Soyoung Won, Jiyoung Lee, Chan-Bum Choi, Jung-Yoon Choe, Seung-Jae Hong, Jae-Bum Jun, Tae-Hwan Kim, Eunmi Koh, Hye-Soon Lee, Jisoo Lee, Dae-Hyun Yoo, Bo Young Yoon, Sang-Cheol Bae, Yoon-Kyoung Sung
Background/Aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA). Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this analysis. Patients were further divided into two groups according to the time to diagnosis from symptom onset: the early diagnosis group (time to diagnosis ≤ 1 year) and the late diagnosis group (time to diagnosis > 1 year)...
December 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29225278/physiochemical-properties-and-resorption-progress-of-porcine-skin-derived-collagen-membranes-in-vitro-and-in-vivo-analysis
#10
Yin-Zhe An, You-Kyoung Kim, Su-Min Lim, Yeong-Ku Heo, Mi-Kyung Kwon, Jae-Kook Cha, Jung-Seok Lee, Ui-Won Jung, Seong-Ho Choi
The aim of the present study was to evaluate the physiochemical properties and resorption progress of two cross-linked, porcine skin-derived collagen membranes and compare their features with those of a membrane without cross-linking (Bio-Gide® [BG], Geistlich Biomaterials, Wolhusen, Switzerland). Three porcine skin-derived collagen membranes, dehydrothermally (DHT) crosslinked (experimental), DHT and 1-ethyl-3(3-dimethylaminopropyl)-carbodiimide (DHT/EDC) cross-linked (experimental) and BG were investigated for their morphology, enzyme resistance, and tensile strength in vitro and biodegradation in vivo...
December 8, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29225189/luteolin-attenuates-airway-inflammation-by-inducing-the-transition-of-cd4-cd25-to-cd4-cd25-regulatory-t-cells
#11
Seung-Hyung Kim, Evelyn Saba, Bok-Kyu Kim, Won-Kyung Yang, Yang-Chun Park, Han Jae Shin, Chang Kyun Han, Young Cheol Lee, Man Hee Rhee
Regulatory T cells (Th2) play an important role in autoimmunity and have been shown to exert anti-inflammatory effects in allergic asthma. Mouse model of airway inflammation was used to examine the suppressive activity of luteolin-induced CD4+CD25+ regulatory T cells (Tregs) in vivo. In this study, BALB/c mice were sensitized with ovalbumin antigen (OVA) by aerosol challenge. Then, various biological processes were examined, including airway eosinophilia; mucus hypersecretion; elevation of OVA-specific IgE, expression of Th2 cytokines and chemokine levels; expression of eotaxin 2 and CCR3; and airway hyper responsiveness (AHR)...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29224631/treatment-outcomes-of-rifabutin-containing-regimens-for-rifabutin-sensitive-multidrug-resistant-pulmonary-tuberculosis
#12
Hyun Lee, Soohyun Ahn, Na Young Hwang, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Nam Yong Lee, Won-Jung Koh
OBJECTIVES: The aim of this study was to evaluate whether rifabutin can improve treatment outcomes in patients with rifabutin-sensitive MDR-TB. METHODS: A retrospective cohort study was performed on 76 patients with rifabutin-sensitive MDR-TB who were treated with or without rifabutin between 2006 and 2011. RESULTS: Overall, 75% (57/76) of patients achieved favorable outcomes, including cure (53/76, 70%) and treatment completion (4/76, 5%)...
December 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29223615/differences-in-drug-susceptibility-pattern-between-mycobacterium-avium-and-mycobacterium-intracellulare-isolated-in-respiratory-specimens
#13
Eun Hye Cho, Hee Jae Huh, Dong Joon Song, Seong Mi Moon, Seung-Heon Lee, So Youn Shin, Chang Ki Kim, Chang-Seok Ki, Won-Jung Koh, Nam Yong Lee
Mycobacterium avium complex (MAC) is the most common etiologic organisms of nontuberculous mycobacteria (NTM) lung disease. In this study, we aimed to retrospectively investigate the differences in drug susceptibility patterns of two major MAC species; Mycobacterium avium and Mycobacterium intracellulare. A total of 1883 major two MAC isolates (1060 M. avium and 823 M. intracellulare) from respiratory specimens were included in this study during the period 2011─2016. The minimum inhibitory concentrations (MICs) were determined by broth microdilution method and MIC50/MIC90 values were derived from MIC distribution...
December 6, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29223557/efficacy-and-safety-of-adding-omega-3-fatty-acids-in-statin-treated-patients-with-residual-hypertriglyceridemia-romantic-rosuvastatin-omacor-in-residual-hypertriglyceridemia-a-randomized-double-blind-and-placebo-controlled-trial
#14
Chee Hae Kim, Kyung Ah Han, Jaemyung Yu, Sang Hak Lee, Hui Kyung Jeon, Sang Hyun Kim, Seok Yeon Kim, Ki Hoon Han, Kyungheon Won, Dong-Bin Kim, Kwang-Jae Lee, Kyungwan Min, Dong Won Byun, Sang-Wook Lim, Chul Woo Ahn, SeongHwan Kim, Young Joon Hong, Jidong Sung, Seung-Ho Hur, Soon Jun Hong, Hong-Seok Lim, Ie Byung Park, In Joo Kim, Hyoungwoo Lee, Hyo-Soo Kim
PURPOSE: The purpose of this study was to examine the efficacy and safety of adding ω-3 fatty acids to rosuvastatin in patients with residual hypertriglyceridemia despite statin treatment. METHODS: This study was a multicenter, randomized, double-blind, placebo-controlled study. After a 4-week run-in period of rosuvastatin treatment, the patients who had residual hypertriglyceridemia were randomized to receive rosuvastatin 20 mg/d plus ω-3 fatty acids 4 g/d (ROSUMEGA group) or rosuvastatin 20 mg/d (rosuvastatin group) with a 1:1 ratio and were prescribed each medication for 8 weeks...
December 6, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29221297/current-status-of-asthma-care-in-south-korea-nationwide-the-health-insurance-review-and-assessment-service-database
#15
Joon Young Choi, Hyoung Kyu Yoon, Jae Ha Lee, Kwang Ha Yoo, Bo Yeon Kim, Hye Won Bae, Young Kyoon Kim, Chin Kook Rhee
Background: Quality control is important for patients with asthma because of its prevalence and because the social burden is substantial. This study analyzed the Health Insurance Review and Assessment Service (HIRA) database to assess asthma quality control in South Korea. Methods: We investigated the HIRA nationwide database for reimbursed insurance claims from all medical institutions in South Korea from July 2013 to June 2014. The number of patients with asthma were evaluated and the medical institutions were categorized by type of medical institution...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29220421/optimal-dose-of-dabigatran-for-the-prevention-of-thromboembolism-with-minimal-bleeding-risk-in-korean-patients-with-atrial-fibrillation
#16
Ki Hong Lee, Hyung Wook Park, Nuri Lee, Dae Young Hyun, Jumin Won, Sung Sik Oh, Hyuk Jin Park, Yongcheol Kim, Jae Yeong Cho, Min Chul Kim, Doo Sun Sim, Hyun Joo Yoon, Nam Sik Yoon, Kye Hun Kim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Myung Ho Jeong, Jong Chun Park, Jeong Gwan Cho
Aims: We aim to determine the optimal dose of dabigatran in Korean patients with atrial fibrillation (AF). Methods and results: We analysed 1834 patients with non-valvular AF, classified into a warfarin group (n = 990), dabigatran 150 mg group (D150, n = 294), and 110 mg group (D110, n = 550). The D110 group was further classified into patients concordant (co-D110, n = 367) and patients discordant (di-D110, n = 183) with guidelines to dose reduction...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29219802/in-situ-high-resolution-transmission-electron-microscopy-tem-observation-of-sn-nanoparticles-on-sno2-nanotubes-under-lithiation
#17
Jun Young Cheong, Joon Ha Chang, Sung Joo Kim, Chanhoon Kim, Hyeon Kook Seo, Jae Won Shin, Jong Min Yuk, Jeong Yong Lee, Il-Doo Kim
We trace Sn nanoparticles (NPs) produced from SnO2 nanotubes (NTs) during lithiation initialized by high energy e-beam irradiation. The growth dynamics of Sn NPs is visualized in liquid electrolytes by graphene liquid cell transmission electron microscopy. The observation reveals that Sn NPs grow on the surface of SnO2 NTs via coalescence and the final shape of agglomerated NPs is governed by surface energy of the Sn NPs and the interfacial energy between Sn NPs and SnO2 NTs. Our result will likely benefit more rational material design of the ideal interface for facile ion insertion...
December 8, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29217429/association-of-platelet-count-with-sarcopenic-obesity-in-postmenopausal-women-a-nationwide-population-based-study
#18
Woo-Jin Park, Dong-Hyuk Jung, Ji-Won Lee, Jae-Yong Shim, Yu-Jin Kwon
OBJECTIVES: The aim of this study was to examine the relationship between platelet count and sarcopenic obesity in postmenopausal women. METHOD: This cross-sectional study was conducted using nationally representative data. A total of 2810 postmenopausal women who participated in the 2008-2011 Korea National Health and Nutritional Examination Survey were included in this study. Sarcopenic obesity was defined by a sarcopenia criterion and an obesity criterion. Platelet counts were divided into quartiles as follows: Q, 150-222; Q2, 223-257; Q3, 258-294, and Q4, 295-450 (103/μl)...
December 4, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29215823/validation-of-the-korean-version-of-the-scales-for-outcomes-in-parkinson-s-disease-sleep
#19
Young Hee Sung, Hee Jin Kim, Seong Beom Koh, Joong Seok Kim, Sang Jin Kim, Sang Myung Cheon, Jin Whan Cho, Yoon Joong Kim, Hyeo Il Ma, Mee Young Park, Jong Sam Baik, Phil Hyu Lee, Sun Ju Chung, Jong Min Kim, In Uk Song, Han Joon Kim, Ji Young Kim, Do Young Kwon, Jae Hyeok Lee, Jee Young Lee, Ji Seon Kim, Ji Young Yun, Jin Yong Hong, Mi Jung Kim, Jinyoung Youn, Ji Sun Kim, Eung Seok Oh, Hui Jun Yang, Won Tae Yoon, Sooyeoun You, Kyum Yil Kwon, Hyung Eun Park, Su Yun Lee, Younsoo Kim, Hee Tae Kim, Tae Beom Ahn
BACKGROUND: Sleep problems commonly occur in patients with Parkinson's disease (PD), and are associated with a lower quality of life. The aim of the current study was to translate the English version of the Scales for Outcomes in Parkinson's Disease-Sleep (SCOPA-S) into the Korean version of SCOPA-S (K-SCOPA-S), and to evaluate its reliability and validity for use by Korean-speaking patients with PD. METHODS: In total, 136 patients with PD from 27 movement disorder centres of university-affiliated hospitals in Korea were enrolled in this study...
January 8, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29215819/prevalence-of-malnutrition-in-hospitalized-patients-a-multicenter-cross-sectional-study
#20
Min Chang Kang, Ji Hoon Kim, Seung Wan Ryu, Jae Young Moon, Je Hoon Park, Jong Kyung Park, Jong Hoon Park, Hyun Wook Baik, Jeong Meen Seo, Myoung Won Son, Geun Am Song, Dong Woo Shin, Yeon Myung Shin, Hong Yup Ahn, Han Kwang Yang, Hee Chul Yu, Ik Jin Yun, Jae Gil Lee, Jae Myeong Lee, Jung Hwa Lee, Tae Hee Lee, Haejun Yim, Hyun Jeong Jeon, Kyuwhan Jung, Mi Ran Jung, Chi Young Jeong, Hee Sook Lim, Suk Kyung Hong
BACKGROUND: Malnutrition is associated with many adverse clinical outcomes. The present study aimed to identify the prevalence of malnutrition in hospitalized patients in Korea, evaluate the association between malnutrition and clinical outcomes, and ascertain the risk factors of malnutrition. METHODS: A multicenter cross-sectional study was performed with 300 patients recruited from among the patients admitted in 25 hospitals on January 6, 2014. Nutritional status was assessed by using the Subjective Global Assessment (SGA)...
January 8, 2018: Journal of Korean Medical Science
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