keyword
https://read.qxmd.com/read/38477546/reference-values-for-serum-calcium-in-neonates-should-be-established-in-a-population-of-vitamin-d-replete-subjects
#21
JOURNAL ARTICLE
Lucie Levaillant, Agnès Linglart, Vincent Gajdos, Alexandra Benachi, Jean-Claude Souberbielle
INTRODUCTION: Serum calcium is frequently measured during the neonatal period, and is known to be influenced by the vitamin D status. We hypothesized that the 25OHD concentration may influence the lower limit of the serum calcium normal range in neonates. METHODS: We included in our prospective cohort study 1002 mother-newborn pair recruited from April 2012 to July 2014, in two centers located in the neighborhoods of Paris, France, whose serum calcium was measured at 3 days of life...
March 13, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38476203/randomized-double-blinded-comparison-of-intermittent-boluses-phenylephrine-and-norepinephrine-for-the-treatment-of-postspinal-hypotension-in-patients-with-severe-pre-eclampsia-during-cesarean-section
#22
RANDOMIZED CONTROLLED TRIAL
Zheng-Bin Pan, Zhi-Min Sheng, Miao Zhu, Zhong Mei, Yan-Ping Shen, Jin-Ping Liu, Xiao-Wei Qian
BACKGROUND: Norepinephrine has fewer negative effects on heart rate (HR) and cardiac output (CO) for treating postspinal hypotension (PSH) compared with phenylephrine during cesarean section. However, it remains unclear whether fetuses from patients with severe pre-eclampsia could benefit from the superiority of CO. The objective of this study was to compare the safety and efficacy of intermittent intravenous boluses of phenylephrine and norepinephrine used in equipotent doses for treating postspinal hypotension in patients with severe pre-eclampsia during cesarean section...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38475814/cd19-cd20-dual-targeted-chimeric-antigen-receptor-engineered-natural-killer-cells-exhibit-improved-cytotoxicity-against-acute-lymphoblastic-leukemia
#23
JOURNAL ARTICLE
Na Yang, Caili Zhang, Yingchun Zhang, Yuting Fan, Jing Zhang, Xiaojin Lin, Ting Guo, Yangzuo Gu, Jieheng Wu, Jianmei Gao, Xing Zhao, Zhixu He
BACKGROUND: Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed in CAR-T cell therapy. However, our prior study revealed challenges in CAR-NK cells targeting CD19 antigens, as they failed to eliminate CD19+ Raji cells in NSG tumor-bearing mice, noting down-regulation or loss of CD19 antigen expression in some Raji cells. In response, this study aims to enhance CD19 CAR-NK cell efficacy and mitigate the risk of tumor recurrence due to target antigen escape by developing CD19 and CD20 (CD19/CD20) dual-targeted CAR-NK cells...
March 13, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38475797/hematologic-health-services-and-practical-characteristics-report-of-a-nationwide-survey-among-chinese-hematologists
#24
JOURNAL ARTICLE
Jia Chen, Jiali Gu, Yuhua Ru, Jianxiang Wang, Yu Hu, Kaiyan Liu, Qifa Liu, Xiaohui Zhang, Zhijian Xiao, Weili Zhao, Yang Xu, Xiaojun Huang, Depei Wu
BACKGROUND: In the past 40 years, China has experienced tremendous economic development, but the current situation of hematologists has rarely been reported. A landscape survey of human resources is essential for healthcare development and policy formulation in the future. METHODS: The Chinese Society of Hematology initiated a survey of Chinese hematologists in mainland China for evaluating demographic and practice characteristics. Respondents were anonymous, and there were no limitations regarding their age, sex, etc...
March 12, 2024: BMC Health Services Research
https://read.qxmd.com/read/38474827/high-initial-dose-of-monitored-vitamin-d-supplementation-in-preterm-infants-hidvid-trial-study-protocol-for-a-randomized-controlled-study
#25
JOURNAL ARTICLE
Dominika Paw, Renata Bokiniec, Alicja Kołodziejczyk-Nowotarska
Vitamin D deficiency can escalate prematurity bone disease in preterm infants and negatively influence their immature immunology system. Infants born at 24 + 0/7 weeks to 32 + 6/7 weeks of gestation will be considered for inclusion. Cord or vein blood samples will be obtained within 48 h after birth for 25-hydroxyvitamin D level measurements. Parathyroid hormone and interleukin-6 levels will be measured. Infants will be randomized to the monitored group (i.e., an initial dose of 1000 IU/day and possible modification) or the controlled group (i...
February 29, 2024: Nutrients
https://read.qxmd.com/read/38473937/independent-and-combined-effects-of-prenatal-alcohol-exposure-and-prenatal-stress-on-fetal-hpa-axis-development
#26
JOURNAL ARTICLE
Ludmila N Bakhireva, Elizabeth Solomon, Melissa H Roberts, Xingya Ma, Rajani Rai, Alexandria Wiesel, Sandra W Jacobson, Joanne Weinberg, Erin D Milligan
Prenatal alcohol exposure (PAE) and prenatal stress (PS) are highly prevalent conditions known to affect fetal programming of the hypothalamic-pituitary-adrenal (HPA) axis. The objectives of this study were to assess the effect of light PAE, PS, and PAE-PS interaction on fetal HPA axis activity assessed via placental and umbilical cord blood biomarkers. Participants of the ENRICH-2 cohort were recruited during the second trimester and classified into the PAE and unexposed control groups. PS was assessed by the Perceived Stress Scale...
February 26, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471898/pediatric-central-nervous-system-vascular-malformation-pathological-review-with-diagram
#27
JOURNAL ARTICLE
Se Hoon Kim
Pediatric central nervous system (CNS) vascular malformations are a group of abnormal blood vessel formations within the brain or spinal cord in children. The most crucial point of pediatric CNS vascular malformation is that no golden standard classifications exist. In addition, there is a big gap in knowledge and the viewpoint of clinicians, radiologists, and pathologists. In addition, many genes associated with pediatric CNS vascular malformation, such as Sturge-Weber-Dimitri syndrome with guanine nucleotide-binding protein G(q) subunit alpha (GNAQ) gene mutation, and cavernous malformations with cerebral cavernous malformations 1 (CCM1), CCM2, and CCM3 gene mutation, were recently revealed...
March 13, 2024: Journal of Korean Neurosurgical Society
https://read.qxmd.com/read/38471485/serum-calcium-normal-range-in-1000-term-newborns
#28
JOURNAL ARTICLE
Lucie Levaillant, Agnès Linglart, Emmanuelle Letamendia, Claire Boithias, Samra Ouaras-Lounis, Patrice Thérond, Anne-Sophie Lambert, Mathieu Levaillant, Jean-Claude Souberbielle, Alexandra Benachi, Vincent Gajdos
INTRODUCTION: Serum calcium rapidly declines at birth because of the sudden interruption of the maternal-fetal calcium influx. Several factors are known to influence serum calcium in the first days of life, including circulating concentrations of maternal vitamin D. Objective was to establish the normal range variations of neonatal serum calcium according to the French current vitamin D supplementation during pregnancy, i.e. 100,000 IU of cholecalciferol during the third trimester. METHODS: We included in our prospective cohort study 1002 mother-newborn dyads from, with recruitments from April 2012 to July 2014 in France, in two recruiting centers located in Paris neighborhoods...
March 12, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38469369/maternal-obesity-and-neonatal-metabolic-health-insights-into-insulin-resistance
#29
JOURNAL ARTICLE
Amit D Sonagra, Deepak Parchwani, Ragini Singh, Sagar Dholariya, Anita Motiani, Dvss Ramavataram
Background Maternal obesity is a global health concern that leads to metabolic alterations in the offspring, making them vulnerable to metabolic disorders in adulthood. Early identification of such neonates would provide opportunities to positively alter modifiable risk factors for non-communicable diseases (NCDs) to prevent their occurrence later in life. Objectives This study aimed to assess and contrast insulin resistance (IR) levels in neonates born to mothers with obesity and those born to healthy, non-obese mothers...
March 2024: Curēus
https://read.qxmd.com/read/38469100/importance-and-application-of-wes-in-fetal-genetic-diagnostics-identification-of-novel-aspm-mutation-in-a-fetus-with-microcephaly
#30
Renata Szalai, Agnes Till, Attila Gyenesei, Judit Bene, Kinga Hadzsiev
BACKGROUND: Prenatal whole exome sequencing (WES) approaches can provide genetic diagnosis with rapid turnaround time and high diagnostic rate when conventional tests are negative. Here we report a family with multiple pregnancy loss and with repeated occurrence of fetal microcephaly. METHODS AND RESULTS: Because of positive family history and recurrent structural abnormality during the pregnancies that may lead postnatal neurodevelopmental consequences, WES analysis was indicated...
March 2024: Molecular Genetics and Metabolism Reports
https://read.qxmd.com/read/38468654/perspective-cervical-laminoforaminotomy-clf-is-safer-than-anterior-cervical-diskectomy-fusion-acdf-for-lateral-cervical-disease
#31
REVIEW
Nancy E Epstein, Marc A Agulnick
BACKGROUND: The literature documents that laminoforaminotomy (CLF), whether performed open, minimally invasively, or microendoscopically, is safer than anterior cervical diskectomy/fusion (ACDF) for lateral cervical disease. METHODS: ACDF for lateral cervical disc disease and/or spondylosis exposes patients to multiple major surgical risk factors not encountered with CLF. These include; carotid artery or jugular vein injuries, esophageal tears, dysphagia, recurrent laryngeal nerve injuries, tracheal injuries, and dysphagia...
2024: Surgical Neurology International
https://read.qxmd.com/read/38468559/transcranial-doppler-ultrasound-and-concussion-supplemental-symptoms-with-physiology-a-systematic-review
#32
JOURNAL ARTICLE
Matthew Neill, Joel Burma, Lauren N Miutz, Courtney Kennedy, Linden Penner, Kailey Newel, Jonathan Smirl
Sport-related concussion (SRC) can impair the cerebrovasculature both acutely and chronically. Transcranial Doppler (TCD) ultrasound assessment has the potential to illuminate the mechanisms of impairment and provide an objective evaluation of SRC. The current systematic review investigated studies employing TCD ultrasound assessment of intracranial arteries across three broad categories of cerebrovascular regulation: neurovascular coupling (NVC), cerebrovascular reactivity (CVR), and dynamic cerebral autoregulation (dCA)...
March 12, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38468544/neurovascular-coupling-in-acutely-concussed-adolescent-patients
#33
JOURNAL ARTICLE
Patricia Roby, Anne E Mozel, Matthew F Grady, Tina Master, Kristy B Arbogast
Neurovascular coupling (NVC) uniquely describes cerebrovascular response to neural activation and has demonstrated impairments following concussion in adult patients. It is currently unclear how adolescent patients experience impaired neurovascular coupling acutely following concussion during this dynamic phase of physiological development. The purpose of this study was to investigate NVC in acutely concussed adolescent patients relative to controls. We recruited patients presenting to a sports medicine practice within 28 days of a concussion or a musculoskeletal injury (controls)...
March 12, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38468543/cardiorespiratory-responses-to-acute-intermittent-hypoxia-in-humans-with-chronic-spinal-cord-injury
#34
JOURNAL ARTICLE
Joseph Welch, Alicia Vose, Kathryn Cavka, Gina Brunetti, Louis DeMark, Hannah Snyder, Clayton Wauneka, Geneva Jacobs, Jayakrishnan Nair, Gordon Mitchell, Emily J Fox
Brief exposure to repeated episodes of low inspired oxygen, or acute intermittent hypoxia (AIH), is a promising therapeutic modality to improve motor function after chronic, incomplete spinal cord injury (SCI). Although therapeutic AIH is under extensive investigation in people with SCI, limited data are available concerning cardiorespiratory responses during and following AIH exposure despite implications for AIH safety and tolerability. Thus, we recorded immediate (during treatment) and enduring (up to 30 min post-treatment) cardiorespiratory responses to AIH in 19 participants with chronic SCI (>1 year post injury; injury levels C1 to T6; American Spinal Injury Association Impairment Scale A to D; mean age = 33...
March 12, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38467704/new-insights-and-potential-biomarkers-for-intraventricular-hemorrhage-in-extremely-premature-infant-case-control-study
#35
JOURNAL ARTICLE
Franklin Ducatez, Abdellah Tebani, Lenaig Abily-Donval, Sarah Snanoudj, Carine Pilon, Thomas Plichet, Charlotte Le Chatelier, Soumeya Bekri, Stéphane Marret
BACKGROUND: Despite advancements in neonatal care, germinal matrix-intraventricular hemorrhage impacts 20% of very preterm infants, exacerbating their neurological prognosis. Understanding its complex, multifactorial pathophysiology and rapid onset remains challenging. This study aims to link specific cord blood biomolecules at birth with post-natal germinal matrix-intraventricular hemorrhage onset. METHODS: A monocentric, prospective case-control study was conducted at Rouen University Hospital from 2015 to 2020...
March 11, 2024: Pediatric Research
https://read.qxmd.com/read/38467271/boundary-cap-neural-crest-stem-cells-promote-angiogenesis-after-transplantation-to-avulsed-dorsal-roots-in-mice-and-induce-migration-of-endothelial-cells-in-3d-printed-scaffolds
#36
JOURNAL ARTICLE
Carl Trolle, Yilin Han, Shivaprakash Jagalur Mutt, Gustaf Christoffersson, Elena N Kozlova
Dorsal root avulsion injuries lead to loss of sensation and to reorganization of blood vessels (BVs) in the injured area. The inability of injured sensory axons to re-enter the spinal cord results in permanent loss of sensation, and often also leads to the development of neuropathic pain. Approaches that restore connection between peripheral sensory axons and their CNS targets are thus urgently need. Previous research has shown that sensory axons from peripherally grafted human sensory neurons are able to enter the spinal cord by growing along BVs which penetrate the CNS from the spinal cord surface...
March 9, 2024: Neuroscience Letters
https://read.qxmd.com/read/38467246/diagnostic-value-of-maternal-cord-blood-and-neonatal-biomarkers-for-early-onset-sepsis-a-systematic-review-and-meta-analysis
#37
REVIEW
Lisanne M van Leeuwen, Elandri Fourie, Gerrie van den Brink, Vincent Bekker, Marlies A van Houten
BACKGROUND: An accurate diagnosis of early onset sepsis (EOS) is challenging due to subtle symptoms and the lack of a good diagnostic tool, resulting in considerable antibiotic overtreatment. A biomarker, discriminating between infected and non-infected newborns early in the disease, could improve EOS prediction. Numerous biomarkers have been tested, but have never been compared directly. OBJECTIVE: We aimed to provide a comprehensive overview of early biomarkers and their diagnostic value in maternal samples, umbilical cord blood and neonatal serum...
March 9, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38466262/high-dose-individualized-antithymocyte-globulin-with-therapeutic-drug-monitoring-in-high-risk-cord-blood-transplant
#38
JOURNAL ARTICLE
Rick Admiraal, A Birgitta Versluijs, Alwin D R Huitema, Lysette Ebskamp, Amelia Lacna, C T Klaartje de Kanter, Marc B Bierings, Jaap Jan Boelens, Caroline A Lindemans, Stefan Nierkens
BACKGROUND: Graft-versus-host disease (GvHD) and rejection are main limitations of cord blood transplantation (CBT), more so in patients with severe inflammation or previous rejections. While rigorous T-cell depletion with antithymocyte globulin (ATG) is needed to prevent GvHD and rejection, overexposure to ATG leads to slow T-cell recovery after transplantation, especially in CBT. OBJECTIVE: To evaluate high-dose, upfront ATG with individualized dosing and therapeutic drug monitoring (TDM) in pediatric CBT for patients at high risk for GvHD and rejection...
February 23, 2024: Cytotherapy
https://read.qxmd.com/read/38464284/fluoride-related-changes-in-the-fetal-cord-blood-proteome-a-pilot-study
#39
Sami T Tuomivaara, Dana E Goin, Susan J Fisher, Steven C Hall, Aras N Mattis, Pamela K Den Besten
Background: Fluoride exposure during pregnancy has been associated with various effects on offspring, including changes in behavior and IQ. To provide clues to possible mechanisms by which fluoride affects human fetal development, we completed proteomic analyses of cord blood serum collected from second-trimester pregnant women residing in Northern California with either high or low fluoride exposure, as identified by maternal serum fluoride concentrations. Objective: To identify changes in cord blood proteins associated with maternal serum fluoride concentration in pregnant women living in Northern California...
March 1, 2024: Research Square
https://read.qxmd.com/read/38464203/hu8f4-car-t-cells-with-mutated-fc-spacer-segment-improve-target-specificity-and-mediate-anti-leukemia-activity-in-vivo
#40
Jeffrey Molldrem, Hong He, Rolando Vedia, Sijie Lu, Qiaochuan Li, Kathryn Cox, Lisa St John, Anna Sergeeva, Karen Clise-Dwyer, Gheath Alatrash, Elizabeth Shpall, Qing Ma
Hu8F4 is a T cell receptor (TCR)-like antibody with high affinity for leukemia-associated antigen PR1/HLA-A2 epitope. Adapted into a chimeric antigen receptor (CAR) format, Hu8F4-CAR is comprised of the Hu8F4 scFv, the human IgG1 CH2CH3 extracellular spacer domain, a human CD28 costimulatory domain, and the human CD3ζ signaling domain. We have demonstrated high efficacy of Hu8F4-CAR-T cells against PR1/HLA-A2-expressing cell lines and leukemic blasts from AML patients in vitro. Previous studies have shown that modification of the Fc domains of IgG4 CH2CH3 spacer regions can eliminate activation-induced cell death and off-target killing mediated by mouse Fc gamma receptor (FcgR)-expressing cells...
February 19, 2024: Research Square
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