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https://www.readbyqxmd.com/read/29774557/diabetes-induced-microvascular-complications-at-the-level-of-the-spinal-cord-a-contributing-factor-in-diabetic-neuropathic-pain
#1
N Ved, M E Da Vitoria Lobo, S M Bestall, C L Vidueira, N Beazley-Long, K Ballmer-Hofer, M Hirashima, D O Bates, L F Donaldson, R P Hulse
Abnormalities of neurovascular interactions within the central nervous system of diabetic patients is associated with the onset of many neurological disease states. However, to date, the link between the neurovascular network within the spinal cord and regulation of nociception has not been investigated despite neuropathic pain being common in diabetes. We hypothesised that hyperglycaemia-induced endothelial degeneration in the spinal cord, due to suppression of VEGF-A/VEGFR2 signalling, induces diabetic neuropathic pain...
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29773600/the-interleukin-3-receptor-cd123-targeted-sl-401-mediates-potent-cytotoxic-activity-against-cd34-cd123-cells-from-acute-myeloid-leukemia-myelodysplastic-syndrome-patients-and-healthy-donors
#2
Rajeswaran Mani, Swagata Goswami, Bhavani Gopalakrishnan, Rahul Ramaswamy, Ronni Wasmuth, Minh Tranh, Xiaokui Mo, Amber Gordon, Donna Bucci, David M Lucas, Alice Mims, Christopher Brooks, Adrienne Dorrance, Alison Walker, William Blum, John C Byrd, Gerard Lozanski, Sumithira Vasu, Natarajan Muthusamy
Diseases with clonal hematopoiesis such as myelodysplastic syndrome and acute myeloid leukemia have high rates of relapse. Only a small subset of acute myeloid leukemia patients are cured with chemotherapy alone. Relapse in these diseases occurs at least in part due to the failure to eradicate leukemic stem cells or hematopoietic stem cells in myelodysplastic syndrome. CD123, the alpha chain of the interleukin-3 receptor heterodimer, is expressed on the majority of leukemic stem cells and myelodysplastic syndrome hematopoietic stem cells and in 80% of acute myeloid leukemia...
May 17, 2018: Haematologica
https://www.readbyqxmd.com/read/29772859/-analysis-of-clinical-efficacy-of-unilateral-open-door-cervical-laminoplasty-combined-with-foraminotomy-for-cervical-ossification-of-posterior-longitudinal-ligament
#3
Feng Yang, Ming-Sheng Tan, Xiang-Sheng Tang, Liang-Hai Jiang, Ping Yi, Qing-Ying Hao
OBJECTIVE: To explore the clinical efficacy of unilateral open-door laminoplasty combined with foraminotomy for cervical ossification of posterior longitudinal ligament(OPLL). METHODS: The clinical data of 45 patients with OPLL underwent surgical treatment between September 2011 and September 2015 were retrospectively analyzed. There were 26 males and 19 females with a mean age of 53.6 years old(ranged from 28 to 71 years). Among them, 24 cases received the surgery of unilateral open-door cervical laminoplasty combined with foraminotomy(combined group), and 21 cases received a single unilateral open-door cervical laminoplasty(single group)...
April 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29772352/allogeneic-stem-cell-transplantation-from-hla-mismatched-donors-for-pediatric-patients-with-acute-lymphoblastic-leukemia-treated-according-to-the-2003-bfm-and-2007-international-bfm-studies-impact-of-disease-risk-on-outcomes
#4
Jean-Hugues Dalle, Adriana Balduzzi, Peter Bader, Arjan Lankester, Isaac Yaniv, Jacek Wachowiak, Anna Pieczonka, Marc Bierings, Akif Yesilipek, Petr Sedlacek, Marianne Ifversen, Sabina Sufliarska, Jacek Toporski, Evgenia Glogova, Ulrike Poetschger, Christina Peters
RATIONAL: Allogeneic HSCT is beneficial for pediatric patients with relapsed or (very) high-risk ALL in remission. A total of 1115 consecutive patients were included in the ALL SCT 2003 BFM study and the ALL SCT 2007-International study and were stratified according to relapse risk (Standard vs. High vs. Very High Risk of Relapse) and donor type (Matched Sibling vs. Matched Donor vs. Mismatched Donor). PATIENTS AND METHODS: A total of 148 patients (60% male, median age 8...
May 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29772239/small-gtpase-r-ras-participates-in-neural-tube-formation-in-zebrafish-embryonic-spinal-cord
#5
Shinya Ohata, Hideko Uga, Hitoshi Okamoto, Toshiaki Katada
Ras related (R-Ras), a small GTPase, is involved in the maintenance of apico-basal polarity in neuroepithelial cells of the zebrafish hindbrain, axonal collapse in cultured murine hippocampal neurons, and maturation of blood vessels in adult mice. However, the role of R-Ras in neural tube formation remains unknown. Using antisense morpholino oligonucleotides (AMOs), we found that in the spinal cord of zebrafish embryos, the lumen was formed bilaterally in rras morphants, whereas it was formed at the midline in control embryos...
May 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29771608/paced-breathing-and-phrenic-nerve-responses-evoked-by-epidural-stimulation-following-complete-high-cervical-spinal-cord-injury-in-rats
#6
Tatiana Bezdudnaya, Michael A Lane, Vitaliy Marchenko
Spinal cord injury (SCI) at the level of cervical segments often results in life-threatening respiratory complications and requires long-term mechanical ventilator assistance. Thus, restoring diaphragm activity and regaining voluntary control of breathing are the primary clinical goals for patients with respiratory dysfunction following cervical SCI. Epidural stimulation (EDS) is a promising strategy that has been explored extensively for non-respiratory functions, and to a limited extent within the respiratory system...
May 17, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29771301/anti-tnf-levels-in-cord-blood-at-birth-are-associated-with-anti-tnf-type
#7
Shannon L Kanis, Alison de Lima, Cokkie van der Ent, Dimitris Rizopoulos, C Janneke van der Woude
Background and Aims: Pregnancy guidelines for women with Inflammatory Bowel Disease (IBD) provide recommendations regarding anti-TNF cessation during pregnancy, in order to limit fetal exposure. Although infliximab (IFX) leads to higher anti-TNF concentrations in cord blood than adalimumab (ADA), recommendations are similar. We aimed to demonstrate the effect of anti-TNF cessation during pregnancy on fetal exposure, for IFX and ADA separately. Methods: We conducted a prospective single center cohort study...
May 15, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29766665/identification-of-the-novel-hla-drb1-allele-drb1-14-183-in-a-colombian-umbilical-cord-blood-bank-donor
#8
L-X González-Acero, B Camacho, A M Perdomo-Arciniegas
HLA-DRB1*14:183 has two nucleotide changes from HLA-DRB1-13:44, D to E and F to Y. This article is protected by copyright. All rights reserved.
May 15, 2018: HLA
https://www.readbyqxmd.com/read/29766568/cord-blood-insulin-igf-i-igf-ii-leptin-adiponectin-and-ghrelin-and-their-associations-with-insulin-sensitivity-%C3%AE-cell-function-and-adiposity-in-infancy
#9
D L Zhang, Q Du, A Djemli, P Julien, W D Fraser, Z C Luo
AIM: Vulnerability to insulin resistance and Type 2 diabetes may originate in early life, but little is known about whether any perinatal biomarkers are predictive of later metabolic health. We sought to assess whether cord blood insulin, insulin-like growth factor (IGF)-I, IGF-II, leptin, adiponectin and ghrelin are associated with metabolic health indicators in infancy. METHODS: In a prospective singleton birth cohort, we assessed cord blood insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations in relation to the homeostasis model assessment of insulin resistance (HOMA-IR), β-cell function (HOMA-β), fasting proinsulin-to-insulin ratio, BMI z-score, and the sum of triceps and subscapular skinfold thickness (an indicator of adiposity) in infants at age 1 year (n = 185)...
May 15, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29765429/the-potentials-and-caveats-of-mesenchymal-stromal-cell-based-therapies-in-the-preterm-infant
#10
REVIEW
Judith Gronbach, Tayyab Shahzad, Sarah Radajewski, Cho-Ming Chao, Saverio Bellusci, Rory E Morty, Tobias Reicherzer, Harald Ehrhardt
Preponderance of proinflammatory signals is a characteristic feature of all acute and resulting long-term morbidities of the preterm infant. The proinflammatory actions are best characterized for bronchopulmonary dysplasia (BPD) which is the chronic lung disease of the preterm infant with lifelong restrictions of pulmonary function and severe consequences for psychomotor development and quality of life. Besides BPD, the immature brain, eye, and gut are also exposed to inflammatory injuries provoked by infection, mechanical ventilation, and oxygen toxicity...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765424/public-awareness-on-cord-blood-banking-in-saudi-arabia
#11
Dunia Jawdat, Sulaiman AlTwijri, Hadeel AlSemari, Mayssa Saade, Ahmed Alaskar
Background: In the last decade, cord blood (CB) has proven to be a valuable source of hematopoietic stem cells for transplantation to treat many hematological disorders. Since then, many CB banks have been established worldwide. Our aim was to estimate the level of public awareness of CB banking in Saudi Arabia. Study Design and Methods: A self-administered questionnaire of 22 multiple choices was conveniently distributed, consisting of demographics, awareness measure, attitude toward banking preference, and donation for research data...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765163/polyunsaturated-fatty-acid-status-at-birth-childhood-growth-and-cardiometabolic-risk-a-pooled-analysis-of-the-mefab-and-rhea-cohorts
#12
Nikos Stratakis, Marij Gielen, Katerina Margetaki, Renate H M de Groot, Maria Apostolaki, Georgia Chalkiadaki, Marina Vafeiadi, Vasiliki Leventakou, Marianna Karachaliou, Roger W Godschalk, Manolis Kogevinas, Euripides G Stephanou, Maurice P Zeegers, Leda Chatzi
BACKGROUND/OBJECTIVES: Polyunsaturated fatty acid (PUFA) status during pregnancy has been suggested to influence offspring obesity and cardiometabolic health. We assessed whether prenatal PUFA exposure is associated with rapid infant growth, childhood BMI, and cardiometabolic profile. SUBJECTS/METHODS: In the Dutch MEFAB (n = 266) and Greek RHEA (n = 263) cohorts, we measured n-3 and n-6 PUFA concentrations in cord blood phospholipids, which reflect fetal exposure in late pregnancy...
May 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29764770/haploidentical-stem-cell-transplantation-bone-marrow-vs-peripheral-blood
#13
REVIEW
Zafer Gulbas
Hematopoietic stem cells may be obtained by collection of bone marrow, mobilization and collection of peripheral blood stem cells or umbilical cord blood. Transplantation of peripheral blood hematopoietic cells has increased due to faster engraftment and practicability in both the related, unrelated or haploidentical setting. We reviewed the question of which stem cell source - bone marrow (BM) or peripheral blood (PBSC) - is the most suitable for individuals undergoing haploidentical stem cell transplantation...
April 19, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29763854/inhibition-of-pregnancy-associated-granulocytic-myeloid-derived-suppressor-cell-expansion-and-arginase-1-production-in-preeclampsia
#14
Yinan Wang, Yanhou Liu, Chang Shu, Jiya Wan, Yanhong Shan, Xinyi Zhi, Liguang Sun, Huanfa Yi, Yong-Guang Yang, Jin He
Myeloid-derived suppressor cells (MDSCs) expand in maternal peripheral blood and cord blood during normal pregnancy to maintain maternal-fetal tolerance. Here we investigated the expansion and function of MDSCs in preeclampsia (PE) patients. Maternal peripheral blood mononuclear cells (PBMCs) and cord blood mononuclear cells (CBMCs) were sampled from healthy pregnant women and PE patients, and analyzed for the frequencies and phenotypes of MDSCs and T cells. Serum levels of key human MDSC effector enzymes were measured using appropriate detection kits...
May 9, 2018: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29762163/transcriptional-gene-silencing-limits-cxcr4-associated-depletion-of-bone-marrow-cd34-cells-in-hiv-1-infection
#15
Tetsuo Tsukamoto
OBJECTIVES: Hematological abnormalities that include changes in bone marrow, such as in anemia and pancytopenia, are common among human immunodeficiency virus (HIV)-infected patients, particularly in the advanced stage of disease. Such abnormalities may be caused by a reduced bone marrow function for hematopoiesis. This aim of this study was to determine whether transcriptional gene silence can help to preserve the hosts' hematopoietic potential in addition to peripheral CD4 T cells against CCR5-tropic HIV infection...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29762127/electrospun-fiber-surface-nanotopography-influences-astrocyte-mediated-neurite-outgrowth
#16
Christopher D Johnson, Anthony R D'Amato, Devan L Puhl, Douglas M Wich, Amanda Vespermann, Ryan J Gilbert
Aligned, electrospun fiber scaffolds provide topographical guidance for regenerating neurons and glia after central nervous system injury. To date, no study has explored how fiber surface nanotopography affects astrocyte response to fibrous scaffolds. Astrocytes play important roles in the glial scar, the blood brain barrier, and in maintaining homeostasis in the central nervous system. In this study, electrospun poly L-lactic acid fibers were engineered with smooth, pitted, or divoted surface nanotopography...
May 15, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29761851/endocytosed-factor-v-is-trafficked-to-cd42b-proplatelet-extensions-during-differentiation-of-human-umbilical-cord-blood-derived-megakaryocytes
#17
Jacqueline M Gertz, Kelley C McLean, Beth A Bouchard
Plasma- and platelet-derived factor Va are essential for thrombin generation catalyzed by the prothrombinase complex; however, several observations demonstrate that the platelet-derived cofactor, which is formed following megakaryocyte endocytosis and modification of the plasma procofactor, factor V, is more hemostatically relevant. Factor V endocytosis, as a function of megakaryocyte differentiation and proplatelet formation, was assessed by flow cytometry and microscopy in CD34+ hematopoietic progenitor cells isolated from human umbilical cord blood and cultured for 12 days in the presence of cytokines to induce ex vivo differentiation into megakaryocytes...
May 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29760931/blood-factory-which-stem-cells
#18
Maria Teresa Esposito
Blood transfusions are often essential for treatment of severe anaemia and pregnancy complications. The unavailability of blood is a medical concern, especially in developing countries. New sources of red blood cells (RBC) are under investigation. Several studies have attempted to produce functional RBC from CD34+ haematopoietic stem cells (HSC) isolated from peripheral blood and umbilical cord blood, from embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC). A recent article published in Nature Communications describes a novel model for generating RBC from a stable erythroid cell line obtained from bone marrow CD34+ haematopoietic stem cells (HSC)...
2018: BMC Hematology
https://www.readbyqxmd.com/read/29760810/dna-methylation-and-socioeconomic-status-in-a-mexican-american-birth-cohort
#19
Eric S Coker, Robert Gunier, Karen Huen, Nina Holland, Brenda Eskenazi
Background: Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships. Methods: In a Mexican-American birth cohort of 241 maternal-infant pairs, cord blood samples were measured for repeat element DNA methylation ( LINE-1 and Alu ). Linear mixed effects regression was used to model associations between indicators of the social environment (low household income and education, neighborhood-level characteristics) and repeat element methylation...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29760736/comparison-of-immunological-characteristics-of-mesenchymal-stem-cells-from-the-periodontal-ligament-umbilical-cord-and-adipose-tissue
#20
Jin-Hee Kim, Chris H Jo, Hang-Rae Kim, Young-Il Hwang
Mesenchymal stem cells (MSCs) are of therapeutic importance in the fields of regenerative medicine and immunological diseases. Accordingly, studies evaluating MSCs for clinical applications are increasing. In this study, we characterized MSCs from the periodontal ligament, umbilical cord (UC-MSCs), and adipose tissue, which were relatively easy to obtain with limited ethical concerns regarding their acquisition, and compared their immunological characteristics. Among MSCs isolated from the three different tissues, UC-MSCs grew the fastest in vitro ...
2018: Stem Cells International
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