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https://www.readbyqxmd.com/read/29334695/complex-interplay-among-adiposity-insulin-resistance-and-bone-health
#1
REVIEW
C Ma, K T Tonks, J R Center, D Samocha-Bonet, J R Greenfield
Obesity and osteoporosis are common public health problems. Paradoxically, while obesity is associated with higher bone density, type 2 diabetic obese individuals have an increased fracture risk. Although obesity and insulin resistance co-exist, some obese individuals remain insulin-sensitive. We suggest that the apparent paradox relating obesity, bone density and fracture risk in type 2 diabetes may be at least partly influenced by differences in bone strength and quality between insulin-resistant and insulin-sensitive obese individuals...
January 15, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29334646/17%C3%AE-estradiol-improves-the-efficacy-of-exploited-autologous-bone-marrow-derived-mesenchymal-stem-cells-in-non-union-radial-defect-healing-a-rabbit-model
#2
Delaram Zamani Mazdeh, Pezhman Mirshokraei, Mohammadreza Emami, Ali Mirshahi, Iraj Karimi
Exploiting mesenchymal stem cells (MSCs) appears to be an appealing alternative to the traditional clinical approach in the treatment of non-union bone defects. It has been shown that 17β-estradiol improves the osteogenesis and proliferation potential of the MSCs via estrogen receptors. We investigated the effect of 17β-estradiol on exploiting autologous BMSCs (bone marrow-derived MSCs) for the purpose of healing of radial non-union segmental defect in rabbit. Twenty rabbits were divided into 4 experimental groups: 1...
December 28, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29334613/reduced-mir-144-3p-expression-in-serum-and-bone-mediates-osteoporosis-pathogenesis-by-targeting-rank
#3
Chunqing Wang, Hanliang He, Yu Jiang, Liang Wang, Youjia Xu
Osteoblasts and osteoclasts are responsible for the formation and resorption of bone, respectively. An imbalance between these two processes results in a disease called osteoporosis, in which a decreased level of bone strength increases the risk of a bone fracture. MicroRNAs (miRNAs) are small non-coding RNA molecules of 18-25 nucleotides that have been previously shown to control bone metabolism by regulating osteoblast and osteoclast differentiation. In the present study, we detected the expression pattern of 10 miRNAs in patient serum samples, and identified six miRNAs altered expression in patients with osteoporosis relative to non-osteoporosis...
January 15, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29334282/evaluation-of-dentin-permeability-of-fluorotic-permanent-teeth
#4
K Görkem Ulu Güzel, Münciye Semra Özay Ertürk, Zuhal Kırzıoğlu, Suat Özkorucuklu
OBJECTIVE: The in vitro permeability characteristics of dentin have been studied extensively and used to evaluate the efficacy of various preventative and restorative procedures. The aim of this in vitro study was to precisely determine the dentin permeability of fluorotic premolar teeth using an electronic hydraulic conductance measurement system with photosensors and to compare the data with healthy premolars. METHODS: In total, 40 fluorotic and healthy premolar teeth with complete root formation that were extracted for orthodontic purposes and had no caries, restoration, fractures, or cracks were selected for this study...
January 15, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29332663/results-after-radial-head-arthroplasty-in-unstable-fractures
#5
Ariana Lott, Kari Broder, Abraham Goch, Sanjit R Konda, Kenneth A Egol
BACKGROUND: Whereas most radial head fractures are stable injuries, they sometimes occur as part of complex injury patterns with associated elbow instability. Radial head arthroplasty has been favored in patients with unreconstructable radial head fractures and unstable elbow injuries. The purpose of this study was to review radiographic outcomes, functional outcomes, and complications after radial head arthroplasty for radial head fracture in unstable elbow injuries. METHODS: This study was a retrospective review of radial head fractures treated with radial head arthroplasty by a single surgeon during a 15-year period...
February 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29332029/biomechanical-effects-of-uss-fixation-with-different-screw-insertion-depths-on-the-vertebrae-stiffness-and-screw-stress-for-the-treatment-of-the-l1-fracture
#6
Jifeng Liu, Sheng Yang, Jianmin Lu, Dapeng Fu, Xipeng Liu, Depeng Shang
OBJECTIVE: To evaluate the biomechanical effects of internal fixation with different screw insertion depths on vertebrae stiffness and screw stress for L1 fracture. METHODS: The established L1 fracture was fixed with 10 different depths of screw insertion: 10-100% screw-path length (SPL). Loading on the T12 endplate was simulated. RESULTS: Screws inserted to 60-100% depths has a higher axial displacement of screw against injured vertebrae and maximum stress of screws compared to those of screws inserted to 30-50% depths and 10-20% (P< 0...
December 29, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/29331975/is-postoperative-bracing-after-pedicle-screw-fixation-of-spine-fractures-necessary-study-protocol-of-the-ornot-study-a-randomised-controlled-multicentre-trial
#7
Arjen Johannes Smits, Jaap Deunk, Agnita Stadhouder, Mark Cornelis Altena, Diederik Hendrik Ruth Kempen, Frank Willem Bloemers
INTRODUCTION: The most common surgical treatment of traumatic spine fractures is through a posterior approach using pedicle screws and rods. Postoperative treatment protocols including the use of postoperative orthoses however differ between hospitals and surgeons. A three-point hyperextension orthosis is designed to support proper posture and unload the anterior column. Some motion remains when wearing an orthosis, and its main value in postoperative treatment is therefore believed to be pain relief and patient confidence...
January 13, 2018: BMJ Open
https://www.readbyqxmd.com/read/29331906/strontium-hydroxyapatite-scaffolds-engineered-with-stem-cells-aid-osteointegration-and-osteogenesis-in-osteoporotic-sheep-model
#8
Sunitha Chandran, Sachin J Shenoy, Suresh Babu S, Renjith P Nair, Varma H K, Annie John
Osteoporotic fracture healing is an orthopaedic challenge due to excessive bone resorption and impaired osteogenesis. Majority of current treatment strategies focus on regulating bone resorption and the potential application of Mesenchymal Stem Cells (MSCs) in promoting osteogenesis has not been explored much. Furthermore, the present study has put forth a novel approach, wherein the synergistic action of Strontium (Sr) and MSCs in a single implant may facilitate osteoporotic bone healing. Strontium Hydroxyapatite (SrHA) synthesized by wet precipitation was fabricated into tissue engineered Strontium incorporated Hydroxyapatite (cSrHA) using sheep adipose tissue derived MSCs (ADMSCs)...
December 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29331761/prevention-of-articular-cartilage-degeneration-in-a-rat-model-of-monosodium-iodoacetate-induced-osteoarthritis-by-oral-treatment-with-withaferin-a
#9
Dharmendra Choudhary, Sulekha Adhikary, Naseer Ahmad, Priyanka Kothari, Ashwni Verma, Prabodh Kumar Trivedi, Prabhat Ranjan Mishra, Ritu Trivedi
Withaferin A (WFA), a highly oxygenated withanolide is used for anti-osteoporotic, fracture healing, obesity control as medicine and dietary supplement in Ayurveda and Unani medicine but its potential remains to be investigate for the osteoarthritis studies. In the present study, chondro-protective effects of WFA, under in vitro and in vivo conditions were evaluated. In-vitro pharmacological activity of WFA was tested on rat articular chondrocytes through MTT, DPPH, different staining, FACS and translation studies...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29330745/-treatment-of-rotational-malalignment-of-the-lower-leg
#10
REVIEW
P Keppler
BACKGROUND: Rotational malalignment after intramedullary nailing of tibial shaft fractures is not uncommon. In-toeing and out-toeing conditions in children are often the reason for orthopedic and traumatological medical consultation. OBJECTIVE: Evaluation of diagnostic modalities and therapeutic options for rotational malalignment in relationship to the patient's age. Surgical indications and efficacy of specific surgical techniques. MATERIAL AND METHODS: Systematic literature search in the German Institute for Medical Documentation and Information (DIMDI) and MEDLINE and evaluation of the currently published articles...
January 12, 2018: Der Unfallchirurg
https://www.readbyqxmd.com/read/29329765/usefulness-of-the-trabecular-bone-score-for-assessing-the-risk-of-osteoporotic-fracture
#11
L Redondo, E Puigoriol, J R Rodríguez, P Peris, E Kanterewicz
INTRODUCTION AND OBJECTIVES: The trabecular bone score (TBS) is an imaging technique that assesses the condition of the trabecular microarchitecture. Preliminary results suggest that TBS, along with the bone mineral density assessment, could improve the calculation of the osteoporotic fracture risk. The aim of this study was to analyse TBS values and their relationship with the clinical characteristics, bone mineral density and history of fractures of a cohort of posmenopausal women. MATERIAL AND METHODS: We analysed 2,257 posmenopausal women from the FRODOS cohort, which was created to determine the risk factors for osteoporotic fracture through a clinical survey and bone densitometry with vertebral morphometry...
January 9, 2018: Revista Clínica Española
https://www.readbyqxmd.com/read/29329642/mesenchymal-stem-cell-macrophage-crosstalk-and-bone-healing
#12
Jukka Pajarinen, Tzuhua Lin, Emmanuel Gibon, Yusuke Kohno, Masahiro Maruyama, Karthik Nathan, Laura Lu, Zhenyu Yao, Stuart B Goodman
Recent research has brought about a clear understanding that successful fracture healing is based on carefully coordinated cross-talk between inflammatory and bone forming cells. In particular, the key role that macrophages play in the recruitment and regulation of the differentiation of mesenchymal stem cells (MSCs) during bone regeneration has been brought to focus. Indeed, animal studies have comprehensively demonstrated that fractures do not heal without the direct involvement of macrophages. Yet the exact mechanisms by which macrophages contribute to bone regeneration remain to be elucidated...
January 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29329484/effects-of-teriparatide-compared-with-risedronate-on-the-risk-of-fractures-in-subgroups-of-postmenopausal-women-with-severe-osteoporosis-the-vero-trial
#13
Piet Geusens, Fernando Marin, David L Kendler, Luis A Russo, Cristiano A F Zerbini, Salvatore Minisola, Jean Jacques Body, Eric Lespessailles, Susan L Greenspan, Alicia Bagur, Jan J Stepan, Péter Lakatos, Enrique Casado, Rüdiger Moericke, Pedro López-Romero, Astrid Fahrleitner-Pammer
The 2-year, randomized, double-blind, active-controlled fracture endpoint VERO study included postmenopausal women with established osteoporosis, who had at least 2 moderate or 1 severe baseline vertebral fractures (VFx), and BMD T-score ≤-1.5. Patients were treated with either s.c. daily teriparatide 20 μg or oral weekly risedronate 35 mg. As previously reported, the risk of new VFx and clinical fractures (a composite of clinical VFx and non vertebral fragility fractures [NVFFx]) was statistically significantly reduced with teriparatide compared with risedronate...
January 12, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29328004/thoracolumbar-injury-classification-and-severity-score-in-children-a-reliability-study
#14
Ross L Dawkins, Joseph H Miller, Omar I Ramadan, Michael C Lysek, Elizabeth N Kuhn, Brandon G Rocque, Michael J Conklin, R Shane Tubbs, Beverly C Walters, Bonita S Agee, Curtis J Rozzelle
OBJECTIVE There are many classification systems for injuries of the thoracolumbar spine. The recent Thoracolumbar Injury Classification and Severity Score (TLICS) has been shown to be a reliable tool for adult patients. The aim of this study was to assess the reliability of the TLICS system in pediatric patients. The validity of the TLICS system is assessed in a companion paper. METHODS The medical records of pediatric patients with acute, traumatic thoracolumbar fractures at a single Level 1 trauma center were retrospectively reviewed...
January 12, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29327973/fluoroscopy-guided-percutaneous-vertebroplasty-for-symptomatic-loosened-pedicle-screw-and-instrumentation-associated-vertebral-fracture-an-evaluation-of-initial-experiences-and-technical-note
#15
Tsai-Sheng Fu, Yun-Da Li
OBJECTIVE For symptomatic loosened pedicle screws and instrumentation-associated vertebral fracture, extensive surgery to remove the pedicle screws and extend the instrumentation, along with the reinsertion of more pedicle screws, is usually the treatment of choice. After such a surgery, however, similar complications will still be encountered. In this study the authors propose minimally invasive percutaneous cement augmentation under fluoroscopic guidance as a salvage procedure that eliminates the inherent risks of conventional extensive surgery...
January 12, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29327779/locally-delivered-ethyl-2-5-dihydroxybenzoate-using-3d-printed-bone-implant-for-promotion-of-bone-regeneration-in-a-osteoporotic-animal-model
#16
B-J Kwon, G M Seon, M H Lee, M-A Koo, M S Kim, D Kim, J-J Han, D Kim, J Kim, J-C Park
Osteoporosis is a disease characterized by low bone mass, most commonly caused by an increase in bone resorption that is not matched by sufficient bone formation. The most common complications of postmenopausal osteoporosis are bone-related defects and fractures. Fracture healing is a multifactorial bone regeneration process, influenced by both biological and mechanical factors related to age, osteoporosis and stability of the osteosynthesis. During the treatment of bone defects in osteoporotic conditions, imbalanced bone remodeling is the leading cause for implant failure...
January 12, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29327560/-research-progress-on-reatment-of-unstable-atlas-fracture-with-single-segment-fixation-by-transoral-approach
#17
REVIEW
Li-Ran Wang, Liu-Jun Zhao, Wei-Hu Ma
As a common type of fracture in cervical, atlas fracture is frequently unstable due to its special anatomical structure. In a previous treatment, external fixation was likely to bring low bony union rate and long-term neck pain, while occipito-cervical fusion and atlantoaxial fusion sacrifice range of motion in cervical spine. Reduction and single section fixation of atlas by anterior lateral mass screws through the transoral approach were reported by some scholars, and the retrospective study demonstrated the high healing rate, reservation of cervical ROM and less bleeding...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327559/-combined-surgical-approaches-in-the-treatment-of-complex-tibial-plateau-fractures
#18
Guang-Hua Yuan, Xiao Zheng, Kang Chen
OBJECTIVE: To explore the early clinical efficacy of a posteromedial inverted "L" shape approach combined an assisted antero lateral assisted approach for the treatment of complex fractures of tibial plateau. METHODS: From March 2011 to June 2014, the posteromedial inverted "L" shape approach combined with the antero lateral assisted approach in the treatment of Schatzker type IV, V, VI tibial plateau fracture were performed in 34 cases. There were 23 males and 11 females, ranging in age from18 to 67 years old, averaged 34...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327558/-modified-osteotomy-of-olecranon-for-the-management-of-inter-condylar-fracture-of-the-humerus
#19
Zheng-Feng Mei, Wen-Tao Lei, Dong-Hui Huang, Qi-Hui Zhao, Hang-Bo Qu, Lian-Zhi Ni
OBJECTIVE: To explore the surgical method and clinical outcome of modified osteotomy of olecranon for the treatment of inter-condylar fracture of humerus. METHODS: From May 2007 to December 2012, 32 patients of intercondylar fracture of humerus were treated surgically through the approach of modified osteotomy of olecranon. The patients were 21 males and 11 females with a mean age of 46.3 years (ranged 18 to 65 years). Nineteen fractures occurred on the right extremity and 13 on the left extremity...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29327557/-surgical-treatment-for-14-patients-with-old-fractures-of-humeral-lateral-condyle-in-children
#20
Kai Liu, Ru-Guo Shang, Yan Xiao, Jan-Wei Hu, Yong-Xin Yu
OBJECTIVE: To study clinical effects of operation for the treatment of old fractures of the humerus lateral condyle in children. METHODS: From January 2012 to January 2014 in our department, 14 children of old humeral lateral condyle fractures were treated with operation. Ten cases were male, 4 cases were female; age from 2 to 12 years old, average 5.8 years old. The initial diagnosis was type IIfracture according to the Milch ciassification, the loss of treatment in 11 cases, conservative treatment in 3 cases of nonunion after fracture displacement...
January 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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