keyword
https://read.qxmd.com/read/38635485/thin-free-perforator-flap-as-a-viable-option-for-forefoot-reconstruction-comprehensive-evaluation-of-outcomes
#1
JOURNAL ARTICLE
Eun Song Lee, Da Eun Kim, Kyeong-Tae Lee
BACKGROUND: Reconstruction of forefoot defects often necessitates free tissue transfer due to the limited availability of local tissue. Microsurgical reconstruction of the forefoot remains challenging as it requires durable yet thin, soft tissue coverage for functional restoration. This study aimed to evaluate the efficacy of free thin perforator flaps for forefoot reconstruction, with a focus on functional outcomes. METHODS: Patients who underwent microsurgical forefoot reconstruction between March 2020 and September 2023 were reviewed...
April 18, 2024: Plastic and Reconstructive Surgery
https://read.qxmd.com/read/38635176/family-socioeconomic-status-and-adolescent-substance-use-the-role-of-parent-adolescent-brain-similarity-and-parental-monitoring
#2
JOURNAL ARTICLE
Claudia Clinchard, Tae-Ho Lee, Morgan Lindenmuth, Alexis Brieant, Kirby Deater-Deckard, Kimberly G Noble, Brooks Casas, Jungmeen Kim-Spoon
Greater neural similarity between parents and adolescents may reduce adolescent substance use. Among 70 parent-adolescent dyads, we tested a longitudinal path model in which family economic environment is related to adolescent substance use, directly and indirectly through parent-adolescent neural similarity and parental monitoring. Neural similarity was measured as parent-adolescent pattern similarity in functional brain connectivity at Time 1. Parents reported socioeconomic status and parental monitoring at Time 1...
April 18, 2024: Journal of Family Psychology: JFP
https://read.qxmd.com/read/38634791/risk-factors-for-invasive-candidiasis-in-critically-ill-patients-who-underwent-emergency-gastrointestinal-surgery-for-complicated-intra-abdominal-infection
#3
JOURNAL ARTICLE
Jung Yun Park, Kwan Mo Yang, Jae Young Kwak, Yun Tae Jung
Background: Candida species account for approximately 15% of hospital-associated infections, causing fatal consequences, especially in critically ill patients. This study aimed to evaluate invasive candidiasis (IC) risk factors in critically ill patients undergoing surgery. Patients and Methods: We retrospectively reviewed the medical records of 583 patients who underwent emergency surgery for complicated intra-abdominal infections between January 2016 and December 2021. Patients were divided into two groups according to the presence or absence of IC during their hospital stay...
April 17, 2024: Surgical Infections
https://read.qxmd.com/read/38634770/proton-pump-inhibitors-increase-the-risk-of-carbapenem-resistant-enterobacteriaceae-colonization-by-facilitating-the-transfer-of-antibiotic-resistance-genes-among-bacteria-in-the-gut-microbiome
#4
JOURNAL ARTICLE
Imchang Lee, Jae-Won Jo, Heung-Jeong Woo, Ki Tae Suk, Seung Soon Lee, Bong-Soo Kim
Carbapenem-resistant Enterobacteriaceae (CRE) pose a global health threat; however, there is still limited understanding of the risk factors and underlying mechanisms of CRE colonization in the gut microbiome. We conducted a matched case-control study involving 282 intensive care unit patients to analyze influencing covariates on CRE colonization. Subsequently, their effects on the gut microbiome were analyzed in a subset of 98 patients (47 CRE carriers and 51 non-CRE carriers) using whole metagenome sequences...
2024: Gut Microbes
https://read.qxmd.com/read/38633943/transarterial-embolization-for-cystic-artery-pseudoaneurysm-caused-by-hepatocellular-carcinoma-rupture-in-the-gallbladder-a-case-report
#5
Soichiro Okamoto, Yusuke Matsui, Shoichi Komoto, Takao Hiraki
We report the rare case of an 80-year-old man with hepatocellular carcinoma that ruptured in the gallbladder, causing a cystic artery pseudoaneurysm and hemobilia. Emergency transarterial embolization (TAE) successfully controlled the bleeding without causing ischemic cholecystitis. Cone-beam computed tomography angiography was useful in identifying the bleeding branch of the selectively embolized cystic artery. Although the patient had poor liver function (Child-Pugh class C) before TAE, it remarkably improved after embolization due to the resolution of coagulopathy and obstructive jaundice caused by hemobilia...
March 2024: Curēus
https://read.qxmd.com/read/38633052/an-experimental-and-numerical-study-on-adhesion-force-at-the-nanoscale
#6
JOURNAL ARTICLE
Su-Hyun Kim, Pan-Kyu Choi, Yong-Bok Lee, Tae-Soo Kim, Min-Seung Jo, So-Young Lee, Hyun-Woo Min, Jun-Bo Yoon
Adhesion has attracted great interest in science and engineering especially in the field pertaining to nano-science because every form of physical contact is fundamentally a macroscopic observation of interactions between nano-asperities under the adhesion phenomenon. Despite its importance, no practical adhesion prediction model has been developed due to the complexity of examining contact between nano-asperities. Here, we scrutinized the contact phenomenon and developed a contact model, reflecting the physical sequence in which adhesion develops...
April 16, 2024: Nanoscale advances
https://read.qxmd.com/read/38633040/ultrasmall-mn-doped-iron-oxide-nanoparticles-with-dual-hepatobiliary-and-renal-clearances-for-t-1-mr-liver-imaging
#7
JOURNAL ARTICLE
Sanghoon Lee, Arim Byun, Juhee Jo, Jong-Min Suh, Jeasang Yoo, Mi Hee Lim, Ji-Wook Kim, Tae-Hyun Shin, Jin-Sil Choi
Although magnetic nanoparticles demonstrate significant potential as magnetic resonance imaging (MRI) contrast agents, their negative contrasts, liver accumulation, and limited excretion hinder their application. Herein, we developed ultrasmall Mn-doped iron oxide nanoparticles (UMIOs) with distinct advantages as T 1 MRI contrast agents. Exceptionally small particle sizes ( ca. 2 nm) and magnetization values (5 emu gMn+Fe -1 ) of UMIOs provided optimal T 1 contrast effects with an ideally low r 2 / r 1 value of ∼1...
April 16, 2024: Nanoscale advances
https://read.qxmd.com/read/38632349/integrative-common-and-rare-variant-analyses-provide-insights-into-the-genetic-architecture-of-liver-cirrhosis
#8
JOURNAL ARTICLE
Jonas Ghouse, Gardar Sveinbjörnsson, Marijana Vujkovic, Anne-Sofie Seidelin, Helene Gellert-Kristensen, Gustav Ahlberg, Vinicius Tragante, Søren A Rand, Joseph Brancale, Silvia Vilarinho, Pia Rengtved Lundegaard, Erik Sørensen, Christian Erikstrup, Mie Topholm Bruun, Bitten Aagaard Jensen, Søren Brunak, Karina Banasik, Henrik Ullum, Niek Verweij, Luca Lotta, Aris Baras, Tooraj Mirshahi, David J Carey, David E Kaplan, Julie Lynch, Timothy Morgan, Tae-Hwi Schwantes-An, Daniel R Dochtermann, Saiju Pyarajan, Philip S Tsao, Triin Laisk, Reedik Mägi, Julia Kozlitina, Anne Tybjærg-Hansen, David Jones, Kirk U Knowlton, Lincoln Nadauld, Egil Ferkingstad, Einar S Björnsson, Magnus O Ulfarsson, Árni Sturluson, Patrick Sulem, Ole B Pedersen, Sisse R Ostrowski, Daniel F Gudbjartsson, Kari Stefansson, Morten Salling Olesen, Kyong-Mi Chang, Hilma Holm, Henning Bundgaard, Stefan Stender
We report a multi-ancestry genome-wide association study on liver cirrhosis and its associated endophenotypes, alanine aminotransferase (ALT) and γ-glutamyl transferase. Using data from 12 cohorts, including 18,265 cases with cirrhosis, 1,782,047 controls, up to 1 million individuals with liver function tests and a validation cohort of 21,689 cases and 617,729 controls, we identify and validate 14 risk associations for cirrhosis. Many variants are located near genes involved in hepatic lipid metabolism...
April 17, 2024: Nature Genetics
https://read.qxmd.com/read/38632261/efficacy-of-a-new-refractive-multifocal-contact-lens-for-presbyopia
#9
JOURNAL ARTICLE
Do Young Kim, Hyunmin Ahn, Sukyung Lee, Ikhyun Jun, Kyoung Yul Seo, Sang Yeop Kim, Tae-Im Kim
This prospective single-arm study aimed to evaluate the clinical efficacy and safety of a refractive multifocal contact lens for the correction of presbyopia in 22 patients. The participants underwent clinical examinations before and 1 week after wearing a refractive multifocal contact lens (OptaCon ZOOM). The primary endpoints were the corrected distance visual acuity (CDVA) and distance-corrected near visual acuity (DCNVA). Defocus curve, contrast sensitivity, and ocular surface disease index (OSDI) were analyzed...
April 17, 2024: Scientific Reports
https://read.qxmd.com/read/38631566/development-of-innovative-active-packaging-films-using-gelatin-pullulan-based-composites-incorporated-with-cinnamon-essential-oil-loaded-metal-organic-frameworks-for-meat-preservation
#10
JOURNAL ARTICLE
Su Jung Hong, Zohreh Riahi, Gye Hwa Shin, Jun Tae Kim
This study aimed to investigate the effect of cinnamon essential oil (CEO)-loaded metal-organic frameworks (CEO@MOF) on the properties of gelatin/pullulan (Gel/Pull)-based composite films (Gel/Pull-based films). The incorporation of CEO@MOF into Gel/Pull-based films demonstrated significant antimicrobial activity against S. aureus, S. enterica, E. coli, and L. monocytogenes. Additionally, CEO@MOF integrated film exhibited a 98.16 % ABTS radical scavenging, with no significant change in the mechanical properties of the neat Gel/Pull film...
April 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38631540/toxicity-evaluation-of-dose-escalation-in-hypofractionated-regional-nodal-irradiation-for-breast-cancer-a-retrospective-study
#11
JOURNAL ARTICLE
Euidam Kim, Ji Sung Yoo, Yeon-Joo Kim, Jungnam Joo, Eun Sang Oh, Yoonsun Chung, Seung Hyun Chung, Tae Hyun Kim
PURPOSE: Regional nodal irradiation (RNI) to the axilla and supraclavicular area presents distinct toxicities, such as lymphedema and shoulder stiffness, compared to whole-breast irradiation. There is insufficient evidence on the safety of dose-escalation in hypofractionated RNI. We aimed to evaluate and compare toxicity rates in patients with breast cancer who received hypofractionated RNI with and without dose-escalation. METHODS: We retrospectively analyzed 381 patients with breast cancer treated with hypofractionated RNI between March 2015 and February 2017...
April 15, 2024: International Journal of Radiation Oncology, Biology, Physics
https://read.qxmd.com/read/38630474/functional-outcomes-associated-with-blood-pressure-decrease-after-endovascular-thrombectomy
#12
JOURNAL ARTICLE
Jae Wook Jung, Kwang Hyun Kim, Jaeseob Yun, Young Dae Kim, JoonNyung Heo, Hyungwoo Lee, Jin Kyo Choi, Il Hyung Lee, In Hwan Lim, Soon-Ho Hong, Byung Moon Kim, Dong Joon Kim, Na Young Shin, Bang-Hoon Cho, Seong Hwan Ahn, Hyungjong Park, Sung-Il Sohn, Jeong-Ho Hong, Tae-Jin Song, Yoonkyung Chang, Gyu Sik Kim, Kwon-Duk Seo, Kijeong Lee, Jun Young Chang, Jung Hwa Seo, Sukyoon Lee, Jang-Hyun Baek, Han-Jin Cho, Dong Hoon Shin, Jinkwon Kim, Joonsang Yoo, Minyoul Baik, Kyung-Yul Lee, Yo Han Jung, Yang-Ha Hwang, Chi Kyung Kim, Jae Guk Kim, Chan Joo Lee, Sungha Park, Soyoung Jeon, Hye Sun Lee, Sun U Kwon, Oh Young Bang, Ji Hoe Heo, Hyo Suk Nam
IMPORTANCE: The associations between blood pressure (BP) decreases induced by medication and functional outcomes in patients with successful endovascular thrombectomy remain uncertain. OBJECTIVE: To evaluate whether BP reductions induced by intravenous BP medications are associated with poor functional outcomes at 3 months. DESIGN, SETTING, AND PARTICIPANTS: This cohort study was a post hoc analysis of the Outcome in Patients Treated With Intra-Arterial Thrombectomy-Optimal Blood Pressure Control trial, a comparison of intensive and conventional BP management during the 24 hours after successful recanalization from June 18, 2020, to November 28, 2022...
April 1, 2024: JAMA Network Open
https://read.qxmd.com/read/38629255/surufatinib-combined-with-transarterial-embolization-versus-surufatinib-monotherapy-in-patients-with-liver-metastatic-neuroendocrine-tumors-study-protocol-for-a-prospective-randomized-controlled-trial
#13
JOURNAL ARTICLE
Ruizhen Li, Xiaofen Li, Xin You, Minggang Su, Yuzhi Liu, Nengwen Ke, Dan Cao
BACKGROUND: More than half of neuroendocrine tumor (NET) patients will experience liver metastasis, and interventional therapy represented by transarterial embolization (TAE) is the main local treatment method. Surufatinib is recommended as a standard systemic treatment for advanced NETs. The efficacy and safety of surufatinib combined with TAE in the treatment of liver metastasis are undetermined. This study was conducted to compare the clinical outcome of surufatinib combined with TAE versus surufatinib monotherapy in liver metastatic NETs...
April 2024: Cancer Medicine
https://read.qxmd.com/read/38627947/gut-microbiota-generated-metabolites-missing-puzzles-to-hosts-health-diseases-and-aging
#14
Yan Zhang, Shibo Wei, Hang Zhang, Yunju Jo, Jong-Sun Kang, Ki-Tae Ha, Jongkil Joo, Hyun Joo Lee, Dongryeol Ryu
The gut microbiota, an intricate community of bacteria residing in the gastrointestinal system, assumes a pivotal role in various physiological processes. Beyond its function in food breakdown and nutrient absorption, gut microbiota exerts a profound influence on immune and metabolic modulation by producing diverse gut microbiota-generated metabolites (GMGMs). These small molecules hold potential to impact host health via multiple pathways, which exhibit remarkable diversity, and have gained increasing attention in recent studies...
April 17, 2024: BMB Reports
https://read.qxmd.com/read/38627470/giant-nanomechanical-energy-storage-capacity-in-twisted-single-walled-carbon-nanotube-ropes
#15
JOURNAL ARTICLE
Shigenori Utsumi, Sanjeev Kumar Ujjain, Satoshi Takahashi, Ryo Shimodomae, Tae Yamaura, Ryosuke Okuda, Ryuichiro Kobayashi, Oga Takahashi, Satoshi Miyazono, Naoki Kato, Keiichi Aburamoto, Yuta Hosoi, Preety Ahuja, Ayumi Furuse, Yuma Kawamata, Hayato Otsuka, Kazunori Fujisawa, Takuya Hayashi, David Tománek, Katsumi Kaneko
A sustainable society requires high-energy storage devices characterized by lightness, compactness, a long life and superior safety, surpassing current battery and supercapacitor technologies. Single-walled carbon nanotubes (SWCNTs), which typically exhibit great toughness, have emerged as promising candidates for innovative energy storage solutions. Here we produced SWCNT ropes wrapped in thermoplastic polyurethane elastomers, and demonstrated experimentally that a twisted rope composed of these SWCNTs possesses the remarkable ability to reversibly store nanomechanical energy...
April 16, 2024: Nature Nanotechnology
https://read.qxmd.com/read/38627421/exploring-fetal-brain-tumor-glioblastoma-symptom-verification-with-self-organizing-maps-and-vulnerability-data-analysis
#16
JOURNAL ARTICLE
Suresh Kumar Natarajan, Jayanthi S, Sandeep Kumar Mathivanan, Hariharan Rajadurai, Benjula Anbu M B, Mohd Asif Shah
Brain tumor glioblastoma is a disease that is caused for a child who has abnormal cells in the brain, which is found using MRI "Magnetic Resonance Imaging" brain image using a powerful magnetic field, radio waves, and a computer to produce detailed images of the body's internal structures it is a standard diagnostic tool for a wide range of medical conditions, from detecting brain and spinal cord injuries to identifying tumors and also in evaluating joint problems. This is treatable, and by enabling the factor for happening, the factor for dissolving the dead tissues...
April 16, 2024: Scientific Reports
https://read.qxmd.com/read/38627375/tuning-the-co-2-reduction-selectivity-of-an-immobilized-molecular-ag-complex-beyond-co
#17
JOURNAL ARTICLE
Mani Balamurugan, Jun Ho Jang, Jeong Eun Kim, Won Il Choi, Young In Jo, Sunghak Park, Elumalai Varathan, Ki Tae Nam
The electrochemical reduction of carbon dioxide (CO2 ) to produce fuels and chemicals has garnered significant attention. However, achieving control over the selectivity of the resulting products remains a challenging task, particularly within molecular systems. In this study, we employed a molecular silver complex immobilized on graphitized mesoporous carbon (GMC) as a catalyst for converting CO2 into CO, achieving an impressive selectivity of over 90% at -1.05 V vs RHE. Notably, the newly formed silver nanoparticles emerged as the active sites responsible for this high CO selectivity rather than the molecular system...
April 16, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38627084/the-potential-role-of-aripiprazole-augmentation-for-major-depressive-disorder-with-anxious-distress-in-naturalistic-treatment-setting
#18
JOURNAL ARTICLE
Seung-Hoon Lee, Kyung Ho Lee, Tae Sun Han, Changsu Han, Won-Myong Bahk, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae
OBJECTIVE: : This study tried to observe clinical benefit of aripiprazole augmentation (ARPA) treatment for major depressive disorder with anxious distress (MDDA) in routine practice. METHODS: : Retrospective chart review (n = 41) was conducted for clinical benefit of ARPA in patients with MDDA in routine practice. The primary endpoint was the mean change of Hamilton Anxiety Rating scale (HAMA) total scores from baseline to the endpoint. Additional secondary endpoints were also retrieved...
May 31, 2024: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://read.qxmd.com/read/38627077/-brain-derived-neurotrophic-factor-methylation-and-long-term-outcomes-after-stroke-interacting-with-suicidal-ideation
#19
JOURNAL ARTICLE
Hee-Ju Kang, Ju-Wan Kim, Joon-Tae Kim, Man-Seok Park, Byung Jo Chun, Sung-Wan Kim, Il-Seon Shin, Robert Stewart, Jae-Min Kim
OBJECTIVE: This study aimed to evaluate the unexplored relationship between BDNF methylation, long-term outcomes, and its interaction with suicidal ideation (SI), which is closely associated with both BDNF expression and stroke outcomes. METHODS: A total of 278 stroke patients were assessed for BDNF methylation status and SI using suicide-related item in the Montgomery-Åsberg Depression Rating Scale at 2 weeks post-stroke. We investigated the incidence of composite cerebro-cardiovascular events (CCVEs) during an 8-14-year period after the initial stroke as long-term stroke outcome...
May 31, 2024: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://read.qxmd.com/read/38626473/prediction-of-postoperative-cerebral-infarction-after-combined-bypass-surgery-in-adult-moyamoya-disease-combining-quantitative-parameters-on-rapid-perfusion-ct-with-clinically-related-factors
#20
JOURNAL ARTICLE
Si Un Lee, Yongjae Lee, Tae Won Choi, Sang Hyo Lee, Young-Deok Kim, Seung Pil Ban, O-Ki Kwon, Chang Wan Oh, Jae Seung Bang
OBJECTIVE: The aim of this study was to identify predictive factors of postoperative cerebral infarction (PostCI) following combined bypass (CB) surgery in adult patients with moyamoya disease (MMD) using quantitative parameters from the rapid processing of perfusion and diffusion (RAPID) perfusion CT (PCT) software. METHODS: The authors retrospectively reviewed 276 total hemispheres in patients with MMD who underwent CB. Preoperative volumes of time-to-maximum (Tmax) > 4 sec and > 6 sec were obtained from the RAPID analysis of PCT...
April 19, 2024: Journal of Neurosurgery
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