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https://www.readbyqxmd.com/read/28227713/gpu-based-cloud-system-for-high-performance-arrhythmia-detection-with-parallel-k-nn-algorithm
#1
Tae Joon Jun, Hyun Ji Park, Hyuk Yoo, Young-Hak Kim, Daeyoung Kim, Tae Joon Jun, Hyun Ji Park, Hyuk Yoo, Young-Hak Kim, Daeyoung Kim, Tae Joon Jun, Hyun Ji Park, Young-Hak Kim, Daeyoung Kim, Hyuk Yoo
In this paper, we propose an GPU based Cloud system for high-performance arrhythmia detection. Pan-Tompkins algorithm is used for QRS detection and we optimized beat classification algorithm with K-Nearest Neighbor (K-NN). To support high performance beat classification on the system, we parallelized beat classification algorithm with CUDA to execute the algorithm on virtualized GPU devices on the Cloud system. MIT-BIH Arrhythmia database is used for validation of the algorithm. The system achieved about 93...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226854/a-distributed-current-stimulator-asic-for-high-density-neural-stimulation
#2
Jeong Hoan Park, Chaebin Kim, Seung-Hee Ahn, Tae Mok Gwon, Joonsoo Jeong, Sang Beom Jun, Sung June Kim, Jeong Hoan Park, Chaebin Kim, Seung-Hee Ahn, Tae Mok Gwon, Joonsoo Jeong, Sang Beom Jun, Sung June Kim, Sung June Kim, Joonsoo Jeong, Sang Beom Jun, Tae Mok Gwon, Chaebin Kim, Seung-Hee Ahn, Jeong Hoan Park
This paper presents a novel distributed neural stimulator scheme. Instead of a single stimulator ASIC in the package, multiple ASICs are embedded at each electrode site for stimulation with a high density electrode array. This distributed architecture enables the simplification of wiring between electrodes and stimulator ASIC that otherwise could become too complex as the number of electrode increases. The individual ASIC chip is designed to have a shared data bus that independently controls multiple stimulating channels...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225569/hepatic-alanine-differentiates-nonalcoholic-steatohepatitis-from-simple-steatosis-in-humans-and-mice-a-proton-mr-spectroscopy-study-with-long-echo-time
#3
Tae-Hoon Kim, Hong Young Jun, Ki-Jong Kim, Young Hwan Lee, Myeung Su Lee, Keum Ha Choi, Ki Jung Yun, Yong Yeon Jeong, Chung Hwan Jun, Eun Young Cho, Kwon-Ha Yoon
PURPOSE: To evaluate the hepatic metabolic alterations in nonalcoholic fatty liver disease (NAFLD) by using (1) H-MRS (proton magnetic resonance spectroscopy) with long echo time and to test the reproducibility of human study in an animal model. Liver biopsy is the gold standard for diagnosing NAFLD but with practical constraints. (1) H-MRS allows in vivo assessment of hepatocellular metabolism and has shown potential for biochemical differentiation in diffuse liver disease. MATERIALS AND METHODS: In all, 32 subjects (11 patients with nonalcoholic steatohepatitis [NASH], 15 with simple steatosis [SS], and six healthy controls) were studied...
February 22, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28225503/association-of-serum-ferritin-with-insulin-resistance-abdominal-obesity-and-metabolic-syndrome-in-korean-adolescent-and-adults-the-korean-national-health-and-nutrition-examination-survey-2008-to-2011
#4
Young Suk Shim, Min Jae Kang, Yeon Jeong Oh, Joon Woo Baek, Seung Yang, Il Tae Hwang
This study aimed to evaluate the associations of serum ferritin with insulin resistance indices, body fat mass/percentage, and all the components of metabolic syndrome (MetS), as well as the risk for MetS according to serum ferritin levels in Korean adolescents and adults.A total of 15,963 Korean males and females aged 16 to 80 years were analyzed using data from the Korean National Health and Nutrition Examination Survey, 2005 to 2011.The median serum ferritin concentration was 98.82 ng/mL for males and 38...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28224800/a-water-indicator-strip-instantaneous-fluorogenic-detection-of-water-in-organic-solvents-drugs-and-foodstuffs
#5
Tae-Il Kim, Youngmi Kim
A simple, highly sensitive and rapid reaction-based colorimetric and fluorescent indicator 1 has been developed for the qual-itative and quantitative determination of water. The water-induced sensitive (LOD = 0.003%, v/v) and fast (< 10 s) change in emission properties was applied to the determination of water in organic solvents, drugs, and foodstuffs in both solution and practical solid state indicator paper strips.
February 22, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28224789/ultra-sensitive-room-temperature-operable-gas-sensors-using-p-type-na-zno-nanoflowers-for-diabetes-detection
#6
Rawat Jaisutti, Minkyung Lee, Jaeyoung Kim, Seungbeom Choi, Tae-Jun Ha, Jaekyun Kim, Hyoungsub Kim, Sung Kyu Park, Yong-Hoon Kim
Ultra-sensitive room-temperature operable gas sensors utilizing the photocatalytic activity of Na-doped p-type ZnO (Na:ZnO) nanoflowers (NFs) are demonstrated as a promising candidate for diabetes detection. The flowerlike Na:ZnO nano-particles possessing ultrathin hierarchical nanosheets were synthesized by a facile solution route at a low process temperature of 40 (o)C. It was found that the Na element acting as a p-type dopant was successfully incorporated in the ZnO lattice. Based on the synthesized p-type Na:ZnO NFs, room-temperature operable chemiresistive-type gas sensors were realized, activated by ultraviolet (UV) illumination...
February 22, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28224766/thromboelastographic-evaluation-of-coagulation-in-patients-with-liver-disease
#7
Kyung Hwa Shin, In Suk Kim, Hyun Ji Lee, Hyung Hoi Kim, Chulhun L Chang, Young Mi Hong, Ki Tae Yoon, Mong Cho
BACKGROUND: The aims of this study were to investigate the parameters of thromboelastography (TEG) for evaluating coagulopathy and to reveal an association with disease severity and/or transfusion requirement in patients with chronic liver disease (CLD) in a clinical laboratory setting. METHODS: We enrolled two groups of adult patients with cirrhotic (N=123) and non-cirrhotic liver disease (N=52), as well as 84 healthy controls. Reaction time (R), kinetic time (K), α-angle (α), maximal amplitude (MA), and coagulation index (CI) were measured with kaolin-activated citrated blood with the TEG 5000 system (Haemonetics Corporation, USA)...
May 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28224619/fl-asparaginase-mediated-downregulation-of-c-myc-promotes-1-25-oh-2-d3-induced-myeloid-differentiation-in-acute-myeloid-leukemia-cells
#8
Ju Han Song, Eunchong Park, Myun Soo Kim, Kyung-Min Cho, Su-Ho Park, Arim Lee, Jiseon Song, Hyeoung-Joon Kim, Jeong-Tae Koh, Tae Sung Kim
Treatment of acute myeloid leukemia (AML) largely depends on chemotherapy, but current regimens have been unsatisfactory for long-term remission. Although differentiation induction therapy utilizing 1,25(OH)2 D3 (VD3) has shown great promise for the improvement of AML treatment efficacy, severe side effects caused by its supraphysiological dose limit its clinical application. Here we investigated the combinatorial effect of l-asparaginase (ASNase)-mediated amino acid depletion and the latent alternation of VD3 activity on the induction of myeloid differentiation...
February 22, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28223744/usefulness-of-dermoscopy-in-the-differential-diagnosis-of-ruptured-and-unruptured-epidermal-cysts
#9
Kee Suck Suh, Dong Young Kang, Jong Bin Park, Myeong Hyeon Yang, Joon Hee Kim, Kang Hoon Lee, Sang Hwa Han, Yun Deok Choi, Sang Tae Kim, Min Soo Jang
BACKGROUND: An epidermal cyst is a common keratin-filled epithelial-lined cyst. The treatment of choice for epidermal cysts is surgical excision. If the cyst becomes ruptured, incision and drainage with oral antibiotic therapy or intralesional steroid injection are required. OBJECTIVE: To analyze the dermoscopic features that can differentiate between ruptured and unruptured epidermal cysts. METHODS: The clinical and dermoscopic features of the pathologically confirmed epidermal cysts of two subgroups of 38 patients, 20 with unruptured cysts and 18 with ruptured cysts, were reviewed...
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28223235/interleukin-32-inflammation-and-cancer
#10
REVIEW
Jin Tae Hong, Dong Ju Son, Chong Kil Lee, Do-Young Yoon, Dong Hun Lee, Mi Hee Park
Interleukin-32 (IL-32) is a novel cytokine involved in inflammation and cancer development. IL-32 gene consists of eight small exons, and IL-32 mRNA has nine alternative spliced isoforms, and was thought to be secreted because it contains an internal signal sequence and lacks a transmembrane region. IL-32 is initially expressed selectively in activated T cells by mitogen and activated NK cells and their expression is strongly augmented by microbes, mitogens, and other cytokines. The IL-32 is induced mainly by pathogens and pro-inflammatory cytokines, but IL-32 is more prominent in immune cells than in non-immune tissues...
February 13, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28223130/antitumor-and-antimetastatic-activities-of-rhamnogalacturonan-ii-type-polysaccharide-isolated-from-mature-leaves-of-green-tea-via-activation-of-macrophages-and-natural-killer-cells
#11
Hye-Ryung Park, Dahyun Hwang, Hyung-Joo Suh, Kwang-Won Yu, Tae Young Kim, Kwang-Soon Shin
To investigate the antitumor and antimetastatic polysaccharide from the mature leaves of green tea, GTE-II was purified using size exclusion chromatography. GTE-II consisted of 15 different sugars including rarely observed sugars such as 2-O-methyl-fucose, 2-O-methyl-xylose, apiose, aceric acid, 3-deoxy-D-manno-2-octulosonic acid, and 3-deoxy-D-lyxo-2-heptulosaric acid, which were characteristic of pectic polysaccharide rhamnogalacturonan-II. Treatment of peritoneal macrophages with GTE-II not only increased interleukin (IL)-6 and IL-12 production, but also had significantly increased tumoricidal activity against Yac-1 tumor cells than those obtained from untreated mice...
February 13, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28223103/her2-amplification-and-cetuximab-efficacy-in-patients-with-metastatic-colorectal-cancer-harboring-wild-type-ras-and-braf
#12
Jae Ho Jeong, Jihun Kim, Yong Sang Hong, Dalyong Kim, Jeong Eun Kim, Sun Young Kim, Kyu-Pyo Kim, Young-Kwang Yoon, Deokhoon Kim, Sung-Min Chun, Yangsoon Park, Se Jin Jang, Tae Won Kim
BACKGROUND: Cetuximab has shown clinical benefit in patients with metastatic colorectal cancer (mCRC) harboring wild-type RAS. Human epidermal growth factor receptor 2 (HER2) amplification may be a mechanism of cetuximab resistance. We evaluated the association between HER2 amplification and cetuximab efficacy in patients with mCRC harboring wild-type RAS and BRAF. PATIENTS AND METHODS: Between December 2003 and June 2013, we identified 142 patients with mCRC whose tumors harbored both wild-type exons 2, 3, and 4 in KRAS and NRAS, and wild-type exon 15 in BRAF using high throughput sequencing (OncoMap version 4...
January 25, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/28222481/effect-of-diquafosol-three-per-cent-ophthalmic-solution-on-tear-film-and-corneal-aberrations-after-cataract-surgery
#13
Hun Lee, Sang Myung Kim, Seonghee Choi, Kyoung Yul Seo, Eung Kweon Kim, Tae-Im Kim
BACKGROUND: The aim was to evaluate the effect of diquafosol on tear film parameters and corneal aberrations after cataract surgery. METHODS: This retrospective, comparative, observational case series included patients who underwent cataract surgery with or without peri-operative use of diquafosol three per cent ophthalmic solution. Patients in group I (31 eyes) were treated with diquafosol three per cent ophthalmic solution six times a day from one week before surgery to three months after surgery...
February 21, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/28221973/a-bioprocessed-polysaccharide-from-lentinus-edodes-mycelia-cultures-with-turmeric-protects-chicks-from-a-lethal-challenge-of-salmonella-gallinarum
#14
Dalmuri Han, Hyung Tae Lee, June Bong Lee, Yongbaek Kim, Sang Jong Lee, Jang Won Yoon
Our previous studies demonstrated that a bioprocessed polysaccharide (BPP) isolated from Lentinus edodes mushroom mycelia cultures supplemented with black rice bran can protect mice against Salmonella lipopolysaccharide-induced endotoxemia and reduce the mortality from Salmonella Typhimurium infection through upregulated T-helper 1 immunity. Here, we report that a BPP from L. edodes mushroom mycelia liquid cultures supplemented with turmeric (referred to as BPP-turmeric) alters chicken macrophage responses against avian-adapted Salmonella Gallinarum and protects chicks against a lethal challenge from Salmonella Gallinarum...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28220692/diagnostic-approach-using-ercp-guided-transpapillary-forceps-biopsy-or-eus-guided-fine-needle-aspiration-biopsy-according-to-the-nature-of-stricture-segment-for-patients-with-suspected-malignant-biliary-stricture
#15
Yun Nah Lee, Jong Ho Moon, Hyun Jong Choi, Hee Kyung Kim, Seo-Youn Choi, Moon Han Choi, Tae Hee Lee, Tae Hoon Lee, Sang-Woo Cha, Sang-Heum Park
In malignant biliary stricture (MBS), the diagnostic accuracy of ERCP-based tissue sampling is insufficient. EUS-guided fine needle aspiration biopsy (EUS-FNAB) is emerging as a reliable diagnostic procedure. This study aimed to evaluate the usefulness of a diagnostic approach using ERCP-guided transpapillary forceps biopsy (TPB) or EUS-FNAB according to the characteristics of suspected MBS. Consecutive patients diagnosed with suspected MBS with obstructive jaundice and/or cholangitis were enrolled prospectively...
February 21, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28220532/diagnosing-bladder-outlet-obstruction-using-the-penile-cuff-test-in-men-with-lower-urinary-tract-symptoms
#16
Kwang Jin Ko, Yoon Seok Suh, Tae Heon Kim, Hyun Hwan Sung, Gyu Ha Ryu, Kyu-Sung Lee
AIM: The current standard diagnostic test to evaluate bladder outlet obstruction (BOO) is pressure-flow study (PFS). The penile cuff test (PCT) was introduced as a non-invasive alternative to PFS to determine the isovolumetric bladder pressure and also flow rate. The aim of the study was to evaluate the diagnostic accuracy and acceptability of the PCT, compared to those of PFS, in the assessment of BOO in men. METHODS: A total of 146 consecutive men with an International Prostate Symptom Score (IPSS) >12 and lower urinary tract symptoms (LUTS) for >6 months were included in this single-institution, prospective, diagnostic study...
February 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28219243/light-induced-radical-formation-and-isomerization-of-an-aromatic-thiol-in-solution-followed-by-time-resolved-x-ray-absorption-spectroscopy-at-the-sulfur-k-edge
#17
Miguel Ochmann, Inga von Ahnen, Amy A Cordones, Abid Hussain, Jae Hyuk Lee, Kiryong Hong, Katrin Adamczyk, Oriol Vendrell, Tae Kyu Kim, Robert William Schoenlein, Nils Huse
We applied time-resolved sulfur-1s absorption spectroscopy to a model aromatic thiol system as a promising method for tracking chemical reactions in solution. Sulfur-1s absorption spectroscopy allows tracking multiple sulfur species with a time-resolution of ~70 ps. Experimental transient spectra combined with high-level electronic structure theory allow precise identification of a radical and two thione isomers, which are generated upon illumination with 267 nm radiation. Moreover, the regioselectivity of the thione isomerization is explained by resulting radical frontier orbitals...
February 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28219030/in-situ-synthesized-cadmium-sulfide-nanowire-photosensor-with-a-parylene-passivation-layer-for-chemiluminescent-immunoassays
#18
Ju-Hee Im, Hong-Rae Kim, Byoung-Gi An, Young Wook Chang, Min-Jung Kang, Tae-Geol Lee, Jin Gyeng Son, Jae-Gwan Park, Jae-Chul Pyun
The direct in situ synthesis of cadmium sulfide (CdS) nanowires (NWs) was presented by direct synthesis of CdS NWs on the gold surface of an interdigitated electrode (IDE). In this work, we investigated the effect of a strong oxidant on the surfaces of the CdS NWs using X-ray photoelectron spectroscopy, transmission electron microscopy, and time-of-flight secondary ion mass spectrometry. We also fabricated a parylene-C film as a surface passivation layer for in situ-synthesized CdS NW photosensors and investigated the influence of the parylene-C passivation layer on the photoresponse during the coating of parylene-C under vacuum using a quartz crystal microbalance and a photoanalyzer...
February 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28218825/sulfur-modified-graphitic-carbon-nitride-nanostructures-as-an-efficient-electrocatalyst-for-water-oxidation
#19
Vinayak S Kale, Uk Sim, Jiwoong Yang, Kyoungsuk Jin, Sue In Chae, Woo Je Chang, Arun Kumar Sinha, Heonjin Ha, Chan-Cuk Hwang, Junghyun An, Hyo-Ki Hong, Zonghoon Lee, Ki Tae Nam, Taeghwan Hyeon
There is an urgent need to develop metal-free, low cost, durable, and highly efficient catalysts for industrially important oxygen evolution reactions. Inspired by natural geodes, unique melamine nanogeodes are successfully synthesized using hydrothermal process. Sulfur-modified graphitic carbon nitride (S-modified g-CN x ) electrocatalysts are obtained by annealing these melamine nanogeodes in situ with sulfur. The sulfur modification in the g-CN x structure leads to excellent oxygen evolution reaction activity by lowering the overpotential...
February 20, 2017: Small
https://www.readbyqxmd.com/read/28218362/mechanical-recanalization-for-clot-occlusion-of-venous-access-ports-experimental-study-using-ports-with-clot-occlusion
#20
Myung Gyu Song, Tae-Seok Seo, Baek-Hui Kim, Jeong Ho Kim
PURPOSE: To test the hypothesis that mechanical injection of saline is safe and effective in restoring patency of totally implantable venous access ports (TIVAPs) with clot occlusion. We devised an experimental port model for the evaluation of mechanical TIVAP recanalization prior to its clinical application. MATERIALS AND METHODS: The clot TIVAP occlusion model was constructed by filling the catheter with swine blood and incubating it at 37.5°C. The model was incubated for different lengths of time ranging from 1 day to 7 days...
February 8, 2017: Journal of Vascular Access
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