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https://www.readbyqxmd.com/read/28944423/differential-dna-hydroxymethylation-in-human-uterine-leiomyoma-cells-depending-on-the-phase-of-menstrual-cycle-and-presence-of-med12-gene-mutations
#1
A S Kol'tsova, A A Pendina, O A Efimova, A N Kaminskaya, A V Tikhonov, N S Osinovskaya, I Yu Sultanov, N Yu Shved, M I Kakhiani, V S Baranov
Using immunofluorescence with specific antibodies, we analyzed DNA hydroxymethylation in uncultured cells from 25 human uterine leiomyomas considering the menstrual cycle phase during surgery and the presence of MED12 gene mutations. It was found that each tumor node had specific DNA hydroxymethylation level that did not depend on the presence of mutations in MED12 gene, but depended on the phase of menstrual cycle. The degree of DNA hydroxymethylation was significantly lower in cells of leiomyomas excised during the luteal phase compared to the follicular phase (p=0...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28942695/ovarian-stimulation-under-the-effect-of-isotretinoin
#2
Mauro Cozzolino, Javier Domingo, Sérgio Reis Soares
Isotretinoin (13-cis-retinoic acid) is a pharmaceutical vitamin A analog that is frequently used in the treatment of severe cystic acne, many women at reproductive age being exposed to this substance. This drug has a clearly documented teratogenicity and data from rodents and humans indicate that a direct aggression to ovarian follicles also occurs. Here we report the case of a 29-year-old woman with breast cancer referred for emergency preservation of reproductive potential that used isotretinoin up to the day before the initiation of ovarian stimulation...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28938896/effect-of-local-endometrial-injury-in-proliferative-vs-luteal-phase-on-ivf-outcomes-in-unselected-subfertile-women-undergoing-in-vitro-fertilization
#3
Wenjie Liu, Reshef Tal, He Chao, Minghui Liu, Ying Liu
BACKGROUND: Mechanical endometrial injury prior to IVF has been suggested as a means to increase implantation rates by improving endometrial receptivity. However, the effects of endometrial injury in proliferative vs. luteal phase have not been studied before. This study aimed to explore whether endometrial injury in the proliferative phase of the preceding cycle before in vitro fertilization/embryo transfer (IVF-ET) improves the clinical outcomes in unselected subfertile women compared with injury in luteal phase...
September 22, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28938733/a-phase-iii-randomized-controlled-trial-comparing-the-efficacy-safety-and-tolerability-of-oral-dydrogesterone-versus-micronized-vaginal-progesterone-for-luteal-support-in-in-vitro-fertilization
#4
Herman Tournaye, Gennady T Sukhikh, Elke Kahler, Georg Griesinger
No abstract text is available yet for this article.
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28930874/the-effectiveness-of-fish-oil-supplementation-in-attenuating-exercise-induced-muscle-damage-in-females-during-mid-follicular-and-mid-luteal-menstrual-phases
#5
Sarah K McKinley-Barnard, Thomas L Andre, Josh J Gann, Paul S Hwang, Darryn S Willoughby
The purpose of this study was to determine if the differences in estrogen levels during the female menstrual cycle and fish oil supplementation would attenuate eccentric exercise-induced muscle damage (EIMD) and delayed onset muscle soreness (DOMS). In a double-blind fashion, 22 physically-active females (20.9 ± 1.4 years, 63.5 ± 9.0 kg, 165.2 ± 7.5 cm) were randomly assigned to ingest either 6 grams of fish oil (n = 11) or placebo (n = 11) daily for 21 days. Participants underwent an eccentric exercise bout of the knee extensors on two occasions during the mid-follicular (MF) and mid-luteal (ML) phases of the 28-day menstrual cycle...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930223/successful-pregnancy-after-treatment-with-chinese-herbal-medicine-in-a-43-year-old-woman-with-diminished-ovarian-reserve-and-multiple-uterus-fibrosis-a-case-report
#6
Benqi Teng, Jie Peng, Madeleine Ong, Xianqin Qu
OBJECTIVE: To highlight a natural approach to coexisting oligomenorrhea, subfertility, luteal phase insufficiency and multiple fibroids cohesively when in vitro fertilisation (IVF) has failed. CASE PRESENTATION: A 43-year-old woman with diminished ovarian reserve and multiple uterine fibroids had previously been advised to discontinue IVF treatment. According to Chinese Medicine diagnosis, herbal formulae were prescribed for improving age-related ovarian insufficiency as well as to control the growth of fibroids...
February 9, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28917127/differential-expression-of-ten-candidate-genes-regulating-prostaglandin-action-in-reproductive-tissues-of-buffalo-during-estrous-cycle-and-pregnancy
#7
Ankita Dillipkumar Verma, Manjit Panigrahi, Naseer Ahmad Baba, Sourabh Sulabh, Abdul Sadam, Subhashree Parida, Krishnaswamy Narayanan, Arvind A Sonwane, Bharat Bhushan
Prostaglandins (PGs) are the key mediators of several female reproductive functions, including luteolysis, ovulation, fertilization, implantation, pregnancy, and parturition. The present study was conducted in buffalo endometrial and luteal tissues between nonpregnant and two stages of pregnancy (29-38 days of pregnancy, 48-56 days of pregnancy) tissue samples. The genes involved from synthesis upto receptor level effect of PGs (PGF2α and PGE2) were studied for their relative mRNA expression. We have collected the endometrial and luteal tissues from slaughtered animals and confirmed the stages by external examination and crown vertebral rump length measurement of the foetus...
September 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/28913369/changes-in-the-width-of-the-tibiofibular-syndesmosis-related-to-lower-extremity-joint-dynamics-and-neuromuscular-coordination-on-drop-landing-during-the-menstrual-cycle
#8
Michie Okazaki, Masaaki Kaneko, Yukisato Ishida, Norio Murase, Toshihito Katsumura
BACKGROUND: Many injuries of the lower extremities, especially the knee and ankle, occur during sports activity, and the incidence rate is higher in women than in men. HYPOTHESIS: The hypothesis was that phases of the menstrual cycle affect the width of the tibiofibular syndesmosis during drop landing in healthy young women and that such changes at the tibiofibular joint also affect the dynamics and neuromuscular coordination of the lower extremities. STUDY DESIGN: Descriptive laboratory study...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28911135/is-it-me-or-my-hormones-neuroendocrine-activation-profiles-to-visual-food-stimuli-across-the-menstrual-cycle
#9
Yardena Arnoni-Bauer, Atira Bick, Noa Raz, Tal Imbar, Shoshana Amos, Orly Agmon, Limor Marko, Netta Levin, Ram Weiss
Context: Homeostatic energy balance is controlled via the hypothalamus, whereas regions controlling reward and cognitive decision-making are critical for hedonic eating. Eating varies across the menstrual cycle peaking at the midluteal phase. Objective: To test responses of females with regular cycles during midfollicular and midluteal phase and of users of monophasic oral contraception pills (OCPs) to visual food cues. Design: Participants performed a functional magnetic resonance imaging while exposed to visual food cues in four time points: fasting and fed conditions in midfollicular and midluteal phases...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28904504/role-of-serpine-gene-polymorphism-in-recurrent-implantation-failure-and-preeclampsia
#10
Nidhi Sharma, Jayashree K Srinivasan, Margeret Harriet Priya, Venkatachalam Sibiya
This is a rare case of serpine gene polymorphism causing thrombophilia and recurrent implantation failure following intrauterine insemination. SERPINE1 gene encodes plasminogen activator inhibitor type 1 and inhibits fibrinolysis, or clot dissolution. The 4G variant results in increased expression of SERPINE1 and consequently higher inhibition of fibrinolysis, thus leading to thrombophilia. The patient had unexplained primary infertility for 9 years. Ovulation induction was done with gonadotropin releasing hormone (GnRH) agonist long protocol...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28887482/preliminary-evidence-of-olfactory-signals-of-women-s-fertility-increasing-social-avoidance-behavior-towards-women-in-pair-bonded-men
#11
Chen Oren, Simone G Shamay-Tsoory
Previous studies suggest that women's body odor is perceived as more attractive during ovulation and that exposure to women's chemical signals of high fertility leads to increased mating motivation. Given that pair-bonded men react differently than single men to unfamiliar women, we investigated whether women's chemical signals of fertility influence approach behavior among pair-bonded and single men. In the first experiment, men performed the Comfortable Interpersonal Distance task while exposed to body odor samples from women who were ovulating and from the same women during their luteal phase...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886590/corpora-lutea-in-superovulated-ewes-fed-different-planes-of-nutrition
#12
A Kraisoon, D A Redmer, C S Bass, C Navanukraw, S T Dorsam, V Valkov, A Reyaz, A T Grazul-Bilska
The corpus luteum (CL) is an ovarian structure which is critical for the maintenance of reproductive cyclicity and pregnancy support. Diet and/or diet components may affect some luteal functions. FSH is widely used to induce multiple follicle development and superovulation. We hypothesized that FSH would affect luteal function in ewes fed different nutritional planes. Therefore, the aim of this study was to determine if FSH-treatment affects (1) ovulation rate; (2) CL weight; (3) cell proliferation; (4) vascularity; (5) expression of endothelial nitric oxide (eNOS) and soluble guanylate cyclase (sGC) proteins; and (6) luteal and serum progesterone (P4) concentration in control (C), overfed (O), and underfed (U) ewes at the early- and mid-luteal phases...
August 12, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/28885418/autoimmune-progesterone-dermatitis-presenting-as-stevens-johnson-syndrome
#13
Sara M Drayer, Larry R Laufer, Maureen E Farrell
BACKGROUND: Autoimmune progesterone dermatitis is an uncommon disease presenting with cyclical skin eruptions corresponding with the menstrual cycle luteal phase. Because symptoms are precipitated by rising progesterone levels, treatment relies on hormone suppression. CASE: A 22-year-old nulligravid woman presented with symptoms mistaken for Stevens-Johnson syndrome. A cyclic recurrence of her symptoms was noted, and the diagnosis of autoimmune progesterone dermatitis was made by an intradermal progesterone challenge...
October 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28879096/spontaneous-miscarriage-in-first-trimester-pregnancy-is-associated-with-altered-urinary-metabolite-profile
#14
Chee Wai Ku, Zhen Wei Tan, Mark Kit Lim, Zhi Yang Tam, Chih-Hsien Lin, Sean Pin Ng, John Carson Allen, Sze Min Lek, Thiam Chye Tan, Nguan Soon Tan
Threatened miscarriage is the most common gynecological emergency, occurring in about 20% of pregnant women. Approximately one in four of these patients go on to have spontaneous miscarriage and the etiology of miscarriage still remains elusive. In a bid to identify possible biomarkers and novel treatment targets, many studies have been undertaken to elucidate the pathways that lead to a miscarriage. Luteal phase deficiency has been shown to contribute to miscarriages, and the measurement of serum progesterone as a prognostic marker and the prescription of progesterone supplementation has been proposed as possible diagnostic and treatment methods...
December 2017: BBA Clinical
https://www.readbyqxmd.com/read/28868136/the-menstrual-cycle-affects-recognition-of-emotional-expressions-an-event-related-potential-study
#15
Madoka Yamazaki, Kyoko Tamura
BACKGROUND: Several studies have investigated the relationship between behavioral changes and the menstrual cycle in female subjects at a reproductive age. The present study investigated the relationship between the menstrual cycle and emotional face recognition by measuring the N170 component of ERPs. METHODS: We measured N170 of twelve women in both follicular phase and late luteal phase who were presented with human facial expressions as stimuli (happy and angry)...
2017: F1000Research
https://www.readbyqxmd.com/read/28867888/efficacy-of-combined-cabergoline-and-metformin-compared-to-metformin-alone-on-cycle-regularity-in-patients-with-polycystic-ovarian-disease-with-hyperprolactinemia-a-randomized-clinical-trial
#16
Mervat Ali Mohamed Elsersy
PURPOSE: Polycystic ovarian syndrome (PCOS) is a common reproductive disorder. Increasing serum prolactin in these patients could be detected in both follicular and luteal phase of the normal and stimulated cycles. Hyperprolactinemia affects the hypothalamic-pituitary-ovarian axis causing anovulation and abnormal uterine bleeding. In this study, the efficacy of combined cabergoline and metformin therapy was compared to metformin therapy alone in patients with PCOS on the body mass index, androgen profile and menstrual cycle regulation...
October 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28854586/folate-homocysteine-and-the-ovarian-cycle-among-healthy-regularly-menstruating-women
#17
Kara A Michels, Jean Wactawski-Wende, James L Mills, Karen C Schliep, Audrey J Gaskins, Edwina H Yeung, Keewan Kim, Torie C Plowden, Lindsey A Sjaarda, Ellen N Chaljub, Sunni L Mumford
STUDY QUESTION: How are concentrations of plasma homocysteine and serum folate associated with reproductive hormones and anovulation in regularly menstruating women? SUMMARY ANSWER: Higher homocysteine was associated with sporadic anovulation and hormonal changes that may be indicative of impaired ovulatory function, but higher serum folate was associated only with higher luteal phase progesterone. WHAT IS KNOWN ALREADY: Higher folate levels as well as some variants in genes relevant to one-carbon metabolism, are associated with improved reproductive outcomes and responses to fertility treatment, but only a few small studies have explored the relationship between markers of one-carbon metabolism and menstrual cycle characteristics...
August 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28847143/description-of-three-female-24-h-ultra-endurance-race-winners-in-various-weather-conditions-and-disciplines
#18
Daniela Chlíbková, Thomas Rosemann, Beat Knechtle, Pantelis T. Nikolaidis, Alena Žákovská, Karl Sudi
A The incidence of exercise-associated hyponatremia (EAH) is higher in women than in men. We present three cases of a very mild post-race EAH in female winners of three 24-h ultra races in various weather conditions and disciplines with post-race plasma sodium [Na⁺] levels of 134 mM (Case 1), 133 mM (Case 2) and 134 mM (Case 3). Moreover, Case 1 and Case 2 showed elevated creatine kinase concentrations of >10,000 U/l with an absence of renal function abnormality. The common characteristics were female sex, veteran recreational category, long race experience in the particular sports discipline, excellent race performance, similar total weekly training hours and the presence of luteal phase of the menstrual cycle during the race...
August 31, 2017: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/28847026/relationship-between-anxiety-and-interleukin-10-in-female-soccer-players-with-and-without-premenstrual-syndrome-pms
#19
Roberta Foster, Mauro Vaisberg, Maíta Poli de Araújo, Marcia Aparecida Martins, Tiago Capel, Andre Luis Lacerda Bachi, Zsuzsanna Ilona Katalin de Jármy-Di Bella
Objective To investigate the level of anxiety and its relationship with interleukin (IL)-10 (anti inflammatory cytokine that modulates mood swings) in a group of female soccer players. Methods Fifty-two eumenorrheic soccer players were evaluated (age 19.8 ± 4.7 years). The presence of premenstrual syndrome (PMS) and phases of the menstrual cycle were determined by a daily symptom report (DSR) kept for 3 consecutive months. The concentration of cytokine IL-10 was determined from urine samples collected at four moments: at the follicular and luteal phases of the menstrual cycle, and before (pre) and after (post) the simulated game, and it was quantified by flow cytometry (Luminex xMAP - EMD Millipore, Billerica, MA, USA)...
August 28, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28840001/bronchial-hyperreactivity-in-perimenstrual-asthma-is-associated-with-increased-th-2-response-in-lower-airways
#20
Szymon Skoczynski, Aleksandra Semik-Orzech, Ewa Sozanska, Wojciech Szanecki, Krzysztof Kołodziejczyk, Igor Radziewicz-Winnicki, Andrzej Witek, Władysław Pierzchała, Adam Barczyk
BACKGROUND: Perimenstrual asthma (PMA) is a commonly observed, usually difficult-to-treat asthma phenotype. The mechanisms underlying this phenomenon remain unexplained. The aim of the study was to assess the degree of airway hyperresponsiveness and its relationship to proinflammatory cytokines concentration in lower airways of PMA compared to non-PMA patients. METHODS: Premenopausal women with regular menstrual cycles diagnosed as: PMA (n=12), non-PMA asthmatics (n=9), and healthy controls (n=10) were prospectively followed for 10 weeks over two consecutive menstrual cycles...
July 2017: Journal of Thoracic Disease
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