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https://www.readbyqxmd.com/read/29349660/progestogen-hypersensitivity
#1
REVIEW
Rung-Chi Li, Kathleen M Buchheit, Jonathan A Bernstein
PURPOSE OF REVIEW: Progestogen hypersensitivity (PH) is a rare disorder which usually occurs in women of childbearing age with symptoms ranging from urticaria with or without angioedema, multiple organ involvement consistent with allergic anaphylaxis, to a spectrum of other non-evanescent skin eruptions. In this review, we present a clinical vignette of PH and discuss the clinical presentation and proposed pathomechanisms, diagnosis, and treatment of PH. RECENT FINDINGS: The hypersensitivity symptoms are associated with exogenous progestin exposure (e...
January 19, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29338136/plasmatic-estradiol-concentration-in-the-mid-luteal-phase-is-a-good-prognostic-factor-for-clinical-and-ongoing-pregnancies-during-stimulated-cycles-of-in-vitro-fertilization
#2
Rodopiano S Florêncio, Melaynne S B Meira, Marcos V da Cunha, Mylena N C R Camarço, Eduardo C Castro, Marta C C F Finotti, Vinicius A de Oliveira
OBJECTIVE: To evaluate the predictive efficiency of serum estradiol (E2) concentration in the mid-luteal phase regarding chemical, clinical, and ongoing pregnancies, in patients subjected to IVF/ICSI with fresh embryo transfer. METHODS: One hundred and forty-three patients undergoing IVF/ICSI met all the inclusion criteria for the present study. Most of the patients used antagonists, final maturation was achieved with recombinant chorionic gonadotrophin (HCG), and embryo transfer took place on days 3 to 5, but mostly on day 4...
January 16, 2018: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29337846/25-hydroxyvitamin-d-and-long-menstrual-cycles-in-a-prospective-cohort-study
#3
Anne Marie Z Jukic, Allen J Wilcox, D Robert McConnaughey, Clarice R Weinberg, Anne Z Steiner
BACKGROUND: Vitamin D insufficiency is associated with subfertility and prolonged estrus cycles in animals, but humans have not been well studied. METHODS: A prospective time-to-pregnancy study, Time to Conceive (2010-2015), collected up to 4 months of daily diary data. Participants were healthy, late reproductive-aged women in North Carolina who were attempting pregnancy. We examined menstrual cycle length as a continuous variable, as well as in categories: long (35+ days) and short (≤25 days)...
January 15, 2018: Epidemiology
https://www.readbyqxmd.com/read/29335465/the-high-concentration-of-progesterone-is-harmful-for-endometrial-receptivity-and-decidualization
#4
Yu-Xiang Liang, Li Liu, Zhi-Yong Jin, Xiao-Huan Liang, Yong-Sheng Fu, Xiao-Wei Gu, Zeng-Ming Yang
Progesterone is required for the establishment and maintenance of mammalian pregnancy and widely used for conservative treatment of luteal phase deficiency in clinics. However, there are limited solid evidences available for the optimal timing and dose of progesterone therapy, especially for the possible adverse effects on implantation and decidualization when progesterone is administrated empirically. In our study, mouse models were used to examine effects of excess progesterone on embryo implantation and decidualization...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334205/overexpression-of-endometrial-estrogen-receptor-alpha-in-the-window-of-implantation-in-women-with-unexplained-infertility
#5
Mehran Dorostghoal, Hamid-O-Allah Ghaffari, Farideh Marmazi, Narjes Keikhah
Background: Failure in the endometrial receptivity may account for a significant number of infertility cases including unexplained infertility in women. Reduction in the endometrial estrogen receptor-alpha (ER-α) expression during implantation may be a critical event that coincides with the expression of specific genes and the formation of a receptive endometrium. The aim of the present study was to assess the expression of ER-α in the mid-secretory phase in the endometrium of women with unexplained infertility...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29330698/circulating-hormones-and-mammographic-density-in-premenopausal-women
#6
Kimberly A Bertrand, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Rulla M Tamimi
Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples...
January 12, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/29324286/digit-ratio-2d-4d-and-circulating-testosterone-oestradiol-and-progesterone-levels-across-the-menstrual-cycle
#7
Gareth Richards, Magdalena Klimek, Grazyna Jasienska, Urszula M Marcinkowska
BACKGROUND: Digit ratio (2D:4D) is used by researchers as an indicator of prenatal sex hormone exposure. Two previous studies have examined associations between 2D:4D and circulating sex steroid concentrations across the menstrual cycle in adult females. One reported that digit ratio correlated positively with oestradiol levels, whereas the other found no such effect; neither observed significant associations with progesterone. AIMS: To examine associations between 2D:4D, as well as asymmetry (i...
January 8, 2018: Early Human Development
https://www.readbyqxmd.com/read/29318745/tissue-distribution-of-some-immune-cells-in-bovine-reproductive-tract-during-follicular-and-luteal-phase
#8
Mehmet Erdem Akbalik, Narin Liman, Hakan Sagsoz, Berna Guney Saruhan
More recent studies indicate that immune cells which secrete their secretory products or cytokines play an important role in reproductive system. In our study, immune cell populations (CD8+ T lymphocytes, CD68+ macrophages, plasma cells, siderophages, eosinophils) and expression of major histocompatibility complex (MHC) class I and class II were examined in female reproductive tract during follicular (n = 13) and luteal phase (n = 10). Plasma cells and eosinophil granulocytes are present in few numbers in luminal epithelium, but abundant in longitudinal muscle layer of uterus, whereas siderophages are the dominant cell type in stroma...
January 10, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29318392/relationship-between-melatonin-and-bone-resorption-rhythms-in-premenopausal-women
#9
Melissa A St Hilaire, Shadab A Rahman, Joshua J Gooley, Paula A Witt-Enderby, Steven W Lockley
Although evidence exists for a daily rhythm in bone metabolism, the contribution of factors such as melatonin levels, the light-dark cycle, and the sleep-wake cycle is difficult to differentiate given their highly correlated time courses. To examine these influences on bone resorption, we collected 48-h sequential urine samples under both ambulatory (8-h sleep:16-h wake) and constant routine (CR) (constant wake, posture, nutrition and dim light) conditions from 20 healthy premenopausal women. Urinary 6-sulphatoxymelatonin (aMT6s; ng/h) and the bone resorption marker amino-terminal cross-linked collagen I telopeptide (NTx; bone collagen equivalents nM/h) were assayed and fit by cosinor models to determine significant 24-h rhythms and acrophase...
January 9, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29314170/pulsatility-of-glucocorticoid-hormones-in-pregnancy-changes-with-gestation-and-obesity
#10
Laura I Stirrat, Jamie J Walker, Ksenia Stryjakowska, Natalie Jones, Natalie Zm Homer, Ruth Andrew, Jane E Norman, Stafford L Lightman, Rebecca M Reynolds
OBJECTIVE: Hypothalamic-pituitary-adrenal-axis (HPA) activity is decreased in obese pregnancy and associates with increased fetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal fetal growth but little is known about glucocorticoid pulsatility in pregnancy. We aimed to investigate the ultradian rhythm of glucocorticoid secretion during obese and lean pregnancy and non-pregnancy. DESIGN: Serum cortisol, cortisone, corticosterone and 11-dehydrocorticosterone were measured by LC-MS/MS from samples obtained at 10-minute intervals between 08...
January 5, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29310693/sex-differences-and-functional-hemispheric-asymmetries-during-number-comparison
#11
TiAnni Harris, Andrea Scheuringer, Belinda Pletzer
BACKGROUND: Global-local stimuli are hierarchical structures consisting of a larger global structure which is composed of smaller local stimuli. Numbers are also constructed hierarchically, with multi-digit numbers being made up from single digits. During two-digit number comparison, compatible items (larger number contains larger unit digit, e.g., 53 vs. 68) are processed faster and more accurately than incompatible items (smaller number contains larger unit digit, e.g., 58 vs. 63). This so-called unit-decade-compatibility effect has challenged the holistic model of number processing and suggests that the processing of number magnitudes occurs at least in part, decomposed, i...
January 8, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29305663/investigation-of-auditory-potentials-and-cognitive-impairment-in-premenstrual-syndrome
#12
Ceyda Hayretdag Ors, Handan Işin Ozisik Karaman
Premenstrual syndrome is a term which is used for describing of somatic, cognitive, emotional, and behavioral symptoms that occur during the luteal phase of menstrual cycle in women of reproductive age; symptoms rapidly improve at the onset of menstruation. In this study, we aimed to reveal if cognitive functions are affected or not in PMS and if the subjects are affected, we try to explain this situation by an objective diagnostic test. Ethical committee approval was taken for this project on 09.03.2012 and numbered 050...
January 5, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29301092/metabolomic-profiling-of-bovine-oviductal-fluid-across-the-oestrous-cycle-using-proton-nuclear-magnetic-resonance-spectroscopy
#13
Julie Lamy, Julie Gatien, Florine Dubuisson, Lydie Nadal-Desbarats, Pascal Salvetti, Pascal Mermillod, Marie Saint-Dizier
In the present study we tested whether regulation of the metabolome in bovine oviductal fluid depended on the stage of the oestrous cycle, the side relative to ovulation and local concentrations of steroid hormones. Luminal fluid samples from both oviducts were collected in the preovulatory, postovulatory, mid- and late luteal phases, from cyclic cows at a local abattoir (18-27 cows per stage and side). The metabolomes were assessed by proton nuclear magnetic resonance spectroscopy (H-NMR). In all, 39 metabolites were identified, among which the amino acid glycine and the energy substrates lactate and myoinositol were the most abundant at all stages...
January 5, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29299205/the-correlation-of-anandamide-with-gonadotrophin-and-sex-steroid-hormones-during-the-menstrual-cycle
#14
Na Cui, Luning Wang, Wei Wang, Jie Zhang, Yueming Xu, Lei Jiang, Guimin Hao
Objectives: The purpose of this study was to investigate the change in plasma anandamide (AEA) levels throughout the normal menstrual cycle, and to analyze the relationship among AEA, sex steroids and gonadotrophins. Materials and Methods: The patients were fertile women with normal menstrual cycle, proposed to get in vitro fertilization (IVF) treatment due to oviduct obstruction or male infertility. Patients were divided into two groups, cross-sectional (n=79) and longitudinal (n=10)...
November 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29298169/premenstrual-syndrome-evidence-based-evaluation-and-treatment
#15
Sarah M Appleton
Premenstrual dysphoric disorder (PMDD) is defined by both physical and psychiatric symptoms that impact a woman significantly during the luteal phase of her menstrual cycle. Diagnostic criteria for PMDD were firmly established in the Diagnostic and Statistical Manual of Mental Disorders V in 2013, but many patients fall short of the diagnosis while still appreciably affected by severe premenstrual symptoms. More recent and robust investigations have evaluated the efficacy of treatment ranging from serotonergic therapy to hormonal treatment as well as lifestyle and herbal remedies...
January 2, 2018: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29286179/localized-cyclical-variations-in-immunoproteins-in-the-female-genital-tract-and-the-implications-on-the-design-and-assessment-of-mucosal-infection-and-therapies
#16
Julia Makinde, Clifford Jones, Angela Bartolf, Sengeziwe Sibeko, Susan Baden, Catherine Cosgrove, Robin J Shattock
PROBLEM: Fluctuating hormones regulate reproductive processes in the female genital tract. Consequent changes in the local immunological environment are likely to affect cellular interaction with infectious agents and the assessment of therapies that target mucosal infections. METHOD OF STUDY: We compared Softcup and Weck-Cel sampling protocols and assessed the changes in the concentrations of 39 soluble proteins with menstrual cycle progression in the mucosal and peripheral compartments...
December 29, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29285142/increased-levels-of-ccr7-lo-pd-1-hi-cxcr5-cd4-t-cells-and-associated-factors-bcl-6-cxcr5-il-21-and-il-6-contribute-to-repeated-implantation-failure
#17
Qiaoqiao Gong, Yuejie Zhu, Nannan Pang, Haiquan Ai, Xiaoyun Gong, Xiaolin La, Jianbing Ding
In vitro fertilization-embryo transfer (IVF-ET) can be used by infertile couples to assist with reproduction; however, failure of the embryo to implant into the endometrial lining results in failure of the IVF treatment. The present study investigated the expression of chemokine receptor 7 (CCR7)(lo) programmed death-1(PD-1)(hi) chemokine receptor type 5 (CXCR5)+ cluster of differentiation 4 (CD4)+ T cells and associated factors in patients with repeated implantation failure (RIF). A total of 30 females with RIF and 30 healthy females were enrolled in the current study...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29277698/interactions-between-observer-and-stimuli-fertility-status-endocrine-and-perceptual-responses-to-intrasexual-vocal-fertility-cues
#18
Grant M Ostrander, R Nathan Pipitone, Melanie L Shoup-Knox
Both men and women find female voices more attractive at higher fertility times in the menstrual cycle, suggesting the voice is a cue to fertility and/or hormonal status. Preference for fertile females' voices provides males with an obvious reproduction advantage, however the advantage for female listeners is less clear. One possibility is that attention to the fertility status of potential rivals may enable women to enhance their own reproductive strategies through intrasexual competition. If so, the response to having high fertility voices should include hormonal changes that promote competitive behavior...
December 22, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/29260590/ovulatory-status-and-menstrual-cycle-duration-assessed-by-self-collection-of-urine-on-ph-strips-in-a-population-based-sample-of-french-women-not-using-hormonal-contraception
#19
Lyliane Rosetta, Jean-Christophe Thalabard, Julien Tanniou, Béatrice Ducot, Lorraine Maitrot-Mantelet, Christine Rousset-Jablonski, Aline Bohet, Jean Bouyer, Aline Chimènes, Rémy Slama
BACKGROUND: Assessing menstrual cycle function in the general population using a non-invasive method is challenging, both in non-industrialized and industrialized countries. SUBJECTS AND METHODS: The Observatory of Fecundity in France (Obseff) recruited on a nationwide basis a random sample of 943 women aged 18-44 years with unprotected intercourse. A sub-study was set up to assess the characteristics of a menstrual cycle by using a non-invasive method adapted to the general population...
December 20, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29260367/larger-volume-and-different-functional-connectivity-of-the-amygdala-in-women-with-premenstrual-syndrome
#20
Demao Deng, Yong Pang, Gaoxiong Duan, Huimei Liu, Hai Liao, Peng Liu, Yanfei Liu, Shasha Li, Wenfu Chen, Danhong Wen, Chunmei Xuan, Min Li
OBJECTIVES: To assess structural and functional changes of the amygdala due to premenstrual syndrome (PMS) using magnetic resonance imaging (MRI). METHODS: Twenty PMS patients and 21 healthy control (HC) subjects underwent a 6-min resting-state fMRI scan during the luteal phase as well as scanning high-resolution T1-weighted images. Subcortical amygdala-related volume and functional connectivity (FC) were estimated between the two groups. Each subject completed a daily record of severity of problems (DRSP) to measure the severity of clinical symptoms...
December 19, 2017: European Radiology
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