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Th2 biomarkers

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https://www.readbyqxmd.com/read/28319473/precision-medicine-in-asthma-the-role-of-bronchial-thermoplasty
#1
Amber J Oberle, Praveen Mathur
PURPOSE OF REVIEW: The inflammatory makeup of severe asthma is heterogeneous. Identification of the predominant cellular endotype via biomarkers can aid in the selection of more advanced therapies. This review is clinically focused on how to use these biomarkers to help select between biologic agents and/or bronchial thermoplasty. RECENT FINDINGS: Several Th2 biomarkers exist for the detection of eosinophilic disease; however, the best biomarker for clinical practice is debatable depending upon local resources...
March 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28317944/inferring-biomarkers-for-mycobacterium-avium-subsp-paratuberculosis-infection-and-disease-progression-in-cattle-using-experimental-data
#2
Gesham Magombedze, Tinevimbo Shiri, Shigetoshi Eda, Judy R Stabel
Available diagnostic assays for Mycobacterium avium subsp. paratuberculosis (MAP) have poor sensitivities and cannot detect early stages of infection, therefore, there is need to find new diagnostic markers for early infection detection and disease stages. We analyzed longitudinal IFN-γ, ELISA-antibody and fecal shedding experimental sensitivity scores for MAP infection detection and disease progression. We used both statistical methods and dynamic mathematical models to (i) evaluate the empirical assays (ii) infer and explain biological mechanisms that affect the time evolution of the biomarkers, and (iii) predict disease stages of 57 animals that were naturally infected with MAP...
March 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299382/-immunological-mechanisms-of-allergen-specific-immunotherapy
#3
REVIEW
J-P Allam, N Novak
Allergen-specific immunotherapy is accompanied by multiple changes on the cellular and humoral level. A shift of Th2 immune responses towards immune responses of the Th1 type, which goes along with an increase of regulatory T cells and B cells, IL-10 as well as reduction of effector cells and eosinophils in the tissue, combined with lower IgE production in favor of higher IgG4 production, are regarded as key mechanisms of allergen-specific immunotherapy . A better understanding of immunologic pathways of specific immunotherapy would be essential for the improvement of this therapy as well as for the development of reliable biomarkers capable to monitor therapeutic responses as well as compliance of the patients...
March 15, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28253520/fractional-exhaled-nitric-oxide-a-potential-biomarker-in-allergic-rhinitis
#4
Giorgio Ciprandi, Fabio Gallo, Fabio Luigi Massimo Ricciardolo, Ignazio Cirillo
BACKGROUND: The fractional concentration of exhaled nitric oxide (FeNO) is a surrogate biomarker for Th2-dependent bronchial inflammation. The present study investigated whether FeNO may characterize allergic rhinitis (AR) patients. METHODS: A total of 553 AR patients (497 males, mean age 28.8 years) were evaluated. Those patients with a high FeNO underwent a 2-year follow-up. RESULTS: Increased FeNO was associated with a significantly longer AR duration, impaired lung function, more severe symptoms, and more frequent bronchial hyperresponsiveness (BHR)...
March 3, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28248547/serum-periostin-as-a-biomarker-for-comorbid-chronic-rhinosinusitis-in-patients-with-asthma
#5
Takamitsu Asano, Yoshihiro Kanemitsu, Masaya Takemura, Makoto Yokota, Kensuke Fukumitsu, Norihisa Takeda, Hiroya Ichikawa, Takehiro Uemura, Osamu Takakuwa, Hirotsugu Ohkubo, Ken Maeno, Yutaka Ito, Tetsuya Oguri, Yumi Maki, Junya Ono, Shoichiro Ohta, Yoshihisa Nakamura, Kenji Izuhara, Motohiko Suzuki, Akio Niimi
RATIONALE: Periostin is a matricellular protein that is involved in the pathophysiology of allergic rhinitis, chronic rhinosinusitis, and asthma. Associations of serum periostin with systemic and airway eosinophilic inflammation and comorbid chronic rhinosinusitis in patients with asthma have been demonstrated. Although serum periostin is positioned as a marker of helper T cell 2 (Th2) immune responses, its implication regarding the presence of comorbid upper airway diseases in patients with asthma remains unclear...
March 1, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28237910/immune-markers-of-social-cognitive-bias-in-schizophrenia
#6
Patrick W Dunne, David L Roberts, Marlon P Quinones, Dawn I Velligan, Madelaine Paredes, Consuelo Walss-Bass
Social cognition is impaired in schizophrenia, is relatively independent of purely neurocognitive domains such as attention and executive functioning, and may be the strongest predictor of functional outcome in this disease. Within a motivated reasoning framework, we tested the hypothesis that the anti-inflammatory Th2-associated cytokines, IL-10 and MDC, would be correlated with behavioral measures of social cognitive threat-detection bias (self-referential gaze detection bias and theory of mind (ToM) bias) in delusional versus non-delusional patients...
February 16, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28155222/skewing-towards-treg-and-th2-responses-is-a-characteristic-feature-of-sustained-remission-in-anca-positive-granulomatosis-with-polyangiitis
#7
Wojciech Szczeklik, Bogdan Jakieła, Katarzyna Wawrzycka-Adamczyk, Marek Sanak, Magdalena Hubalewska-Mazgaj, Agnieszka Padjas, Marcin Surmiak, Katarzyna Szczeklik, Jan Sznajd, Jacek Musiał
The objective of our study was to evaluate the T-helper (Th) and regulatory T (Treg) cell profile in ANCA-positive granulomatosis with polyangiitis (GPA) and its relation to disease activity. In a prospective study, we studied two groups of GPA patients: (1) disease flare (active-GPA, BVAS>6, n = 19), (2) sustained remission (≥ 1-year prior enrollment, inactive-GPA, BVAS = 0, n = 18). 24 age-sex matched healthy subjects served as controls. Active-GPA patients were followed for 6 months and reevaluated during remission (early remission; n = 13)...
February 2, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28129666/non-invasive-proteome-analysis-of-psoriatic-stratum-corneum-reflects-pathophysiological-pathways-and-is-useful-for-drug-profiling
#8
B Méhul, G Laffet, A Séraïdaris, L Russo, P Fogel, I Carlavan, C Pernin, P Andres, C Queille-Roussel, J J Voegel
BACKGROUND: Protein expression is disturbed in psoriatic stratum corneum. Non-invasive methods for the description of pathophysiological changes and drug profiling in psoriasis are desirable. OBJECTIVES: Undertake large scale non-invasive protein expression studies in psoriatic stratum corneum to identify biomarkers of pathophysiological processes and use them for drug profiling. METHODS: Psoriatic stratum corneum was harvested through repetitive tape-stripping...
January 27, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28122147/serum-scd30-a-promising-biomarker-for-predicting-the-risk-of-bacterial-infection-after-kidney-transplantation
#9
Mario Fernández-Ruiz, Patricia Parra, Francisco López-Medrano, Tamara Ruiz-Merlo, Esther González, Natalia Polanco, Julia Origüen, Rafael San Juan, Amado Andrés, José María Aguado
BACKGROUND: The transmembrane glycoprotein CD30 contributes to regulate the balance between Th1 and Th2 responses. Previous studies have reported conflicting results on the utility of its soluble form (sCD30) to predict post-transplant infection. METHODS: Serum sCD30 was measured by a commercial ELISA assay at baseline and post-transplant months 1, 3, and 6 in 100 kidney transplant (KT) recipients (279 monitoring points). The impact of sCD30 levels on the incidence of overall, bacterial and opportunistic infection during the first 12 months after transplantation was assessed by Cox regression...
January 25, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28117495/elevated-serum-psa-is-associated-with-human-herpesvirus-8-infection-and-increased-circulating-cytokine-levels-in-men-from-tobago
#10
Jill D Henning, Jaideep M Karamchandani, Luis A Bonachea, Clareann H Bunker, Alan L Patrick, Frank J Jenkins
BACKGROUND: Serum-prostate specific antigen (PSA) levels have been used for many years as a biomarker for prostate cancer. This usage is under scrutiny due to the fact that elevated PSA levels can be caused by other conditions such as benign prostatic hyperplasia and infections of or injury to the prostate. As a result, the identification of specific pathogens capable of increasing serum levels of PSA is important. A potential candidate responsible for elevated PSA is human herpesvirus 8 (HHV-8)...
May 2017: Prostate
https://www.readbyqxmd.com/read/28109493/serum-periostin-level-is-not-associated-with-allergic-rhinitis-or-allergic-sensitization-in-korean-children
#11
Dong Young Kim, Jeong Hong Kim, Keun-Hwa Lee, Seong-Chul Hong, Hye-Sook Lee, Ju Wan Kang
OBJECTIVES: Periostin is a matricellular protein, synthesized in the airway epithelium and induced by interleukin (IL)-4 and IL-13. The significance of periostin as a biomarker of T helper type 2 cell (Th2)-induced airway inflammation, and as a measure of the response to Th2-targeted therapy, has recently been highlighted. We explored the relationship between serum periostin and allergic rhinitis in Korean children. METHODS: Data for fifth and sixth grade children from six randomly selected elementary schools located in Jeju and Seogwipo City, Korea, were investigated...
February 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28063328/long-term-persistence-of-inflammation-in-children-vaccinated-with-salmonella-conjugate-vaccine-is-associated-with-augmented-th9-th17-cytokine
#12
Chinnasamy Balaji, Vijayakumar Kevinkumar, Vivekanandhan Aravindhan
Vaccine induced serum cytokines not only serves as a biomarker of immunity but also serves as a reliable measure of inflammation. Long term persistence of inflammation can lead to metabolic derangement. Towards this end, in the present study, we measured levels of cytokines along with hormones (insulin, leptin and adiponectin) in children who have been vaccinated with Salmonella typhi Vi conjugate vaccine, 30months after vaccination. Vaccinated children showed a unique cytokine profile with suppressed Th1-Th2 and increased Th9-Th17 cytokines indicating immune polarization which was associated with decreased serum adiponectin (but not insulin or leptin) levels...
January 4, 2017: Cytokine
https://www.readbyqxmd.com/read/28058210/biology-of-chronic-graft-vs-host-disease-immune-mechanisms-and-progress-in-biomarker-discovery
#13
REVIEW
Richard B Presland
Chronic graft-vs-host disease (cGVHD) is the leading cause of long-term morbidity and mortality following allogeneic hematopoietic stem cell transplantation. It presents as a chronic inflammatory and sclerotic autoimmune-like condition that most frequently affects the skin, oral mucosa, liver, eyes and gastrointestinal tract. Both clinical and animal studies have shown that multiple T cell subsets including Th1, Th2, Th17, T follicular helper cells and regulatory T-cells play some role in cGVHD development and progression; B cells also play an important role in the disease including the production of antibodies to HY and nuclear antigens that can cause serious tissue damage...
December 24, 2016: World Journal of Transplantation
https://www.readbyqxmd.com/read/28044257/targeted-therapy-for-severe-asthma-identifying-the-right-patients
#14
Kathy Low, Philip G Bardin
Asthma affects over 300 million people worldwide. Most asthmatics are well controlled with inhaled corticosteroids and long-acting beta-agonists; however, a proportion of patients are unresponsive and attain limited disease control. This group represents a considerable healthcare and financial burden, particularly patients who experience frequent exacerbations and require hospital admission. Development of new biological agents and disease biomarkers has provided novel avenues for treatment. These treatments have been highly successful, reducing exacerbations and yielding modest improvements in quality of life and lung function...
January 2, 2017: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28035210/reference-values-for-a-panel-of-cytokinergic-and-regulatory-lymphocyte-subpopulations
#15
Vincenzo Sorrenti, Bruno Marenda, Stefano Fortinguerra, Claudia Cecchetto, Roberta Quartesan, Giulia Zorzi, Morena Zusso, Pietro Giusti, Alessandro Buriani
Lymphocyte subpopulations producing cytokines and exerting regulatory functions represent key immune elements. Given their reciprocal interdependency lymphocyte subpopulations are usually assayed as diagnostic panels, rather than single biomarkers for specialist clinical use. This retrospective analysis on lymphocyte subpopulations, analyzed over the last few years in an outpatient laboratory in Northeast Italy, contributes to the establishment of reference values for several regulatory lymphocytes currently lacking such reference ranges for the general population...
December 2016: Immune Network
https://www.readbyqxmd.com/read/28029801/sinus-computed-tomographic-findings-in-adult-smokers-and-nonsmokers-with-asthma-analysis-of-clinical-indices-and-biomarkers
#16
Hirokazu Kimura, Satoshi Konno, Yuji Nakamaru, Hironi Makita, Natsuko Taniguchi, Kaoruko Shimizu, Masaru Suzuki, Junya Ono, Shoichiro Ohta, Kenji Izuhara, Masaharu Nishimura
RATIONALE: When they occur together, sinusitis and asthma are often thought to represent anatomically separate components of the same chronic inflammatory airway disease. Information about the effect of smoking on the interaction between sinusitis and asthma in patients who have both disorders is limited. OBJECTIVES: To evaluate the effect of cigarette smoking on the relationship between the presence and severity of sinusitis and selected asthma-related indices in adults who have asthma...
March 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28005163/intratumoral-th2-predisposition-combines-with-an-increased-th1-functional-phenotype-in-clinical-response-to-intravesical-bcg-in-bladder-cancer
#17
Renate Pichler, Georg Gruenbacher, Zoran Culig, Andrea Brunner, Dietmar Fuchs, Josef Fritz, Hubert Gander, Andrea Rahm, Martin Thurnher
Th1-type immunity is considered to be required for efficient response to BCG in bladder cancer, although Th2 predisposition of BCG responders has recently been reported. The aim was to evaluate the relationship of Th1 and Th2 components in 23 patients undergoing BCG treatment. Peripheral blood, serum and urine samples were prospectively collected at baseline, during and after BCG. Th1 (neopterin, tryptophan, kynurenine, kynurenine-to-tryptophan ratio (KTR), IL-12, IFN-γ, soluble TNF-R75 and IL-2Rα) and Th2 (IL-4, IL-10) biomarkers as well as CD4 expression in T helper (Th), effector and regulatory T cells were determined...
April 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27978840/validated-and-longitudinally-stable-asthma-phenotypes-based-on-cluster-analysis-of-the-adept-study
#18
Matthew J Loza, Ratko Djukanovic, Kian Fan Chung, Daniel Horowitz, Keying Ma, Patrick Branigan, Elliot S Barnathan, Vedrana S Susulic, Philip E Silkoff, Peter J Sterk, Frédéric Baribaud
BACKGROUND: Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be assessed for stability and to be validated in independent cohorts. The aim of this study was to define and validate, for the first time ever, clinically driven asthma phenotypes using two independent, severe asthma cohorts: ADEPT and U-BIOPRED. METHODS: Fuzzy partition-around-medoid clustering was performed on pre-specified data from the ADEPT participants (n = 156) and independently on data from a subset of U-BIOPRED asthma participants (n = 82) for whom the same variables were available...
December 15, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27965111/sialylated-fetuin-a-as-a-candidate-predictive-biomarker-for-successful-grass-pollen-allergen-immunotherapy
#19
Noémie Caillot, Julien Bouley, Karine Jain, Sandrine Mariano, Sonia Luce, Stéphane Horiot, Sabi Airouche, Chloé Beuraud, Christian Beauvallet, Philippe Devillier, Sylvie Chollet-Martin, Christine Kellenberger, Laurent Mascarell, Henri Chabre, Thierry Batard, Emmanuel Nony, Vincent Lombardi, Véronique Baron-Bodo, Philippe Moingeon
BACKGROUND: Eligibility to immunotherapy is based on the determination of IgE reactivity to a specific allergen by skin prick or in vitro testing. Biomarkers predicting the likelihood of clinical improvement during immunotherapy would significantly improve patient selection. METHODS: Proteins were differentially assessed by 2D-DiGE and label-free mass spectrometry in pre-treatment sera obtained from clinical responders and non-responders within a cohort of 82 grass pollen allergic patients receiving sublingual immunotherapy or placebo...
December 10, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27942351/therapeutic-interventions-in-severe-asthma
#20
REVIEW
Giorgio Walter Canonica, Gianenrico Senna, Patrick D Mitchell, Paul M O'Byrne, Giovanni Passalacqua, Gilda Varricchi
The present paper addresses severe asthma which is limited to 5-10% of the overall population of asthmatics. However, it accounts for 50% or more of socials costs of the disease, as it is responsible for hospitalizations and Emergency Department accesses as well as expensive treatments. The recent identification of different endotypes of asthma, based on the inflammatory pattern, has led to the development of tailored treatments that target different inflammatory mediators. These are major achievements in the perspective of Precision Medicine: a leading approach to the modern treatment strategy...
2016: World Allergy Organization Journal
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