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Th2 biomarkers

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https://www.readbyqxmd.com/read/28629361/decoy-receptor-3-an-endogenous-immunomodulator-in-cancer-growth-and-inflammatory-reactions
#1
REVIEW
Shie-Liang Hsieh, Wan-Wan Lin
Decoy receptor 3 (DcR3), also known as tumor necrosis factor receptor (TNFR) superfamily member 6b (TNFRSF6B), is a soluble decoy receptor which can neutralize the biological functions of three members of tumor necrosis factor superfamily (TNFSF): Fas ligand (FasL), LIGHT, and TL1A. In addition to 'decoy' function, recombinant DcR3.Fc is able to modulate the activation and differentiation of dendritic cells (DCs) and macrophages via 'non-decoy' action. DcR3-treated DCs skew T cell differentiation into Th2 phenotype, while DcR3-treated macrophages behave M2 phenotype...
June 19, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28583618/new-anti-eosinophil-drugs-for-asthma-and-copd-targeting-the-trait
#2
REVIEW
Elisabeth H Bel, Anneke Ten Brinke
Asthma and chronic obstructive airways disease (COPD) are prevalent chronic inflammatory airway diseases that are responsible for a large global disease burden. Both diseases are complex and heterogeneous, and are increasingly recognized as overlapping syndromes that may share similar pathophysiologic mechanisms and treatable traits. Eosinophilic airway inflammation is considered the most influential treatable trait of chronic airway disease, and over the last decade several monoclonal antibodies and small molecule therapies have been developed to target this trait...
June 2, 2017: Chest
https://www.readbyqxmd.com/read/28575534/ccl-2-in-the-circulation-predicts-long-term-progression-of-interstitial-lung-disease-in-early-systemic-sclerosis-patients-data-from-two-independent-cohorts
#3
Minghua Wu, Murray Baron, Claudia Pedroza, Gloria A Salazar, Jun Ying, Julio Charles, Sandeep K Agarwal, Marie Hudson, Janet Pope, Xiaodong Zhou, John D Reveille, Marvin J Fritzler, Maureen D Mayes, Shervin Assassi
OBJECTIVE: There are few clinical predictors of progression of systemic sclerosis (SSc) related interstitial lung disease (ILD). Herein, we examine the predictive significance of key cytokines for long-term progression of ILD and survival in early SSc in two independent cohorts. METHODS: Plasma levels of 11 Th1/Th2 cytokines (IL-1β, IL-5, IL-6, IL-8, IL-10, IL-12, IL-13, TNF-α, CCL-2, ITAC and IP-10) were measured in 266 SSc patients in the GENISOS cohort. Next, CCL-2, IL-10, and IL-6 were measured in 171 early SSc patients from the CSRG replication cohort...
June 2, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28575522/identification-of-biomarker-sets-for-predicting-the-efficacy-of-sublingual-immunotherapy-against-pollen-induced-allergic-rhinitis
#4
Minoru Gotoh, Osamu Kaminuma, Akihiro Nakaya, Kazufumi Katayama, Yuji Motoi, Nobumasa Watanabe, Mayumi Saeki, Tomoe Nishimura, Noriko Kitamura, Kazuko Yamaoka, Kimihiro Okubo, Takachika Hiroi
Sublingual immunotherapy (SLIT) is effective against allergic rhinitis, although a substantial proportion of individuals is refractory. Herein, we describe a predictive modality to reliably identify SLIT non-responders. We conducted a 2-year clinical study in 193 adult patients with Japanese cedar pollinosis, with biweekly administration of 2000 Japanese allergy units of cedar pollen extract as the maintenance dose. After identifying high-responder (HR) patients with improved severity scores and non-responder (NR) patients with unchanged or exacerbated symptoms, differences in 33 HR and 34 NR patients were evaluated in terms of peripheral blood cellular profiles by flow cytometry and serum factors by ELISA and cytokine bead array, both pre- and post-SLIT...
June 2, 2017: International Immunology
https://www.readbyqxmd.com/read/28571570/immunological-and-virological-characterization-of-hiv-1-viremia-controllers-in-the-north-region-of-brazil
#5
Samara Tatielle M Gomes, Érica R Gomes, Mike B Dos Santos, Sandra S Lima, Maria Alice F Queiroz, Luiz Fernando A Machado, Izaura M V Cayres-Vallinoto, Antonio Carlos R Vallinoto, Marluísa de O Guimarães Ishak, Ricardo Ishak
BACKGROUND: A rare phenotype of clinical non-progressors to AIDS is not well understood and the new protocol for universal treatment, may block the understanding of viral control thus it is crucial to define this controversial group. METHODS: A cohort of 30 persons followed a criteria for viremia control groups 1 (VC1; n = 2) and 2 (VC2; n = 7) and non-viral controllers (NC; n = 21) including number of years of diagnosis, LTCD4(+), LTCD8(+) counts, plasma viral load and the absence of ART; 241 uninfected control persons were matched to age and sex...
June 1, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28553015/interluekin-35-in-asthma-and-its-potential-as-an-effective-therapeutic-agent
#6
REVIEW
Peng Gao, Zhenzhong Su, Xuejiao Lv, Jie Zhang
Interleukin- (IL-) 35 is a member of the IL-12 cytokine family and a heterodimeric protein formed by Epstein-Barr-induced gene 3 (EBI3) and IL-12p35. Emerging evidence shows that IL-35 is a key player in the regulation of cellular communication, differentiation, and inflammation. Altered IL-35 expression has been found in disease conditions such as cancer, rheumatoid arthritis, and, more recently, asthma. In cancer, IL-35 is involved in the regulation of tumorigenesis, cancer progression, and metastasis. In rheumatoid arthritis, IL-35 acts as a negative regulator of inflammation...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28531215/association-of-cord-blood-chemokines-and-other-biomarkers-with-neonatal-complications-following-intrauterine-inflammation
#7
Yoshikazu Otsubo, Kunio Hashimoto, Taro Kanbe, Muneichiro Sumi, Hiroyuki Moriuchi
BACKGROUND: Intrauterine inflammation has been associated with preterm birth and neonatal complications. Few reports have comprehensively investigated multiple cytokine profiles in cord blood and precisely identified surrogate markers for intrauterine inflammation. AIM: To identify the cytokines and surrogate markers associated with intrauterine inflammation and subsequent neonatal complications. PATIENTS AND METHODS: We analyzed cord blood samples from 135 patients admitted to the neonatal intensive care unit at Sasebo City General Hospital...
2017: PloS One
https://www.readbyqxmd.com/read/28511944/serum-periostin-in-patients-hospitalized-for-copd-exacerbations
#8
Elissavet Konstantelou, Andriana I Papaioannou, Stelios Loukides, Konstantinos Bartziokas, Anastasia Papaporfyriou, Georgios Papatheodorou, Petros Bakakos, Spyros Papiris, Nikolaos Koulouris, Konstantinos Kostikas
Serum periostin has been proposed as a surrogate biomarker of Th2 inflammatory response in patients with asthma, but its predictive role in hospitalized patients with COPD has not been evaluated. The aim of the present observational prospective cohort study was to evaluate the possible role of serum periostin as predictor of outcome in COPD patients hospitalized for AECOPD. Serum periostin was measured on admission and at discharge in patients admitted to the hospital for a COPD exacerbation. Patients were followed-up for 1year for future exacerbations, hospitalizations and mortality...
May 13, 2017: Cytokine
https://www.readbyqxmd.com/read/28509396/anti-inflammatory-antioxidant-and-immunomodulatory-effects-of-curcumin-in-ovalbumin-sensitized-rat
#9
Farzaneh Shakeri, Mohammad Hossein Boskabady
BACKGROUND: Anti-inflammatory and antioxidant properties of curcumin have been shown. In this study, anti-inflammatory, antioxidant, and immunomodulatory effects of curcumin in sensitized rat were evaluated. METHODS: Six groups of rats including control (C), ovalbumin-sensitized (as a rat model of asthma, S), S groups treated with curcumin (Cu 0.15, 0.30, and 0.60 mg/mL), and 1.25 μg/mL dexamethasone (S + D) were studied. Curcumin and dexamethasone were given in animals' drinking water during sensitization period...
May 16, 2017: BioFactors
https://www.readbyqxmd.com/read/28506264/an-association-between-pulmonary-mycobacterium-avium-intracellulare-complex-infections-and-biomarkers-of-th2-type-inflammation
#10
Paul E Pfeffer, Susan Hopkins, Ian Cropley, David M Lowe, Marc Lipman
BACKGROUND: The rising incidence of pulmonary Mycobacterium avium-intracellulare complex (MAI) infection is unexplained but parallels the growing world-wide epidemic of allergic disease. We hypothesized an association between pulmonary MAI infection and Th2-type immune responses as seen in allergy. METHODS: Biomarkers of patient Th2-type immune responses (peripheral blood eosinophil counts and serum IgE levels) were compared between patients with positive pulmonary samples for tuberculosis and non-tuberculous mycobacterial (NTM) infection...
May 15, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28487565/chemokine-profiles-of-interstitial-pneumonia-in-patients-with-dermatomyositis-a-case-control-study
#11
Katsuhiro Oda, Takuya Kotani, Tohru Takeuchi, Takaaki Ishida, Takeshi Shoda, Kentaro Isoda, Shuzo Yoshida, Yasuichiro Nishimura, Shigeki Makino
Chemokines play an important role in the pathophysiology of dermatomyositis (DM) with interstitial pneumonia (IP). However, the relation between chemokines and the disease activity or prognosis of DM-IP has not been elucidated. We evaluated the serum C-C motif chemokine ligand (CCL) 2, Th1 chemokines (C-X-C motif chemokine ligand [CXCL] 9, CXCL10, CXCL11), and Th2 chemokine (CCL17) profiles of 30 patients, and examined the relation between these chemokines and the disease activity or prognosis of DM-IP. Initial serum CCL2 level was higher in the death group (P = 0...
May 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435890/gene-expression-profile-of-human-cytokines-in-response-to-burkholderia-pseudomallei-infection
#12
Shivankari Krishnananthasivam, Harindra Darshana Sathkumara, Enoka Corea, Mohan Natesan, Aruna Dharshan De Silva
Melioidosis is an underreported infectious disease, caused by the Gram-negative bacterium Burkholderia pseudomallei. Understanding the disease susceptibility and pathogenesis is crucial for developing newer diagnostic and therapeutic strategies for this life-threatening infection. In this study, we aimed to analyze the gene expression levels of important cytokines in melioidosis patients and establish useful correlates with disease biomarkers compared to cases of sepsis infection caused by other pathogens and healthy individuals...
March 2017: MSphere
https://www.readbyqxmd.com/read/28428789/il-10-producing-b-cells-regulate-t-helper-cell-immune-responses-during-1-3-%C3%AE-glucan-induced-lung-inflammation
#13
Fangwei Liu, Xiaowei Lu, Wujing Dai, Yiping Lu, Chao Li, Sitong Du, Ying Chen, Dong Weng, Jie Chen
With the rapid development of industry and farm, fungi contamination widely exists in occupational environment. Inhalation of fungi-contaminated organic dust results in hypersensitivity pneumonitis. 1,3-β-Glucan is a major cell wall component of fungus and is considered as a biomarker of fungi exposure. Current studies showed that 1,3-β-glucan exposure induced lung inflammation, which involved uncontrolled T helper (Th) cell immune responses, such as Th1, Th2, Th17, and regulatory T cell (Treg). A recently identified IL-10-producing B cells (B10) was reported in regulating immune homeostasis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28423971/intrauterine-infection-immune-system-and-premature-birth
#14
Fernanda Rodrigues Helmo, Eduardo Arthur Rodovalho Alves, Renata Alves de Andrade Moreira, Viviane Oliveira Severino, Laura Penna Rocha, Maria Luíza Gonçalves Dos Reis Monteiro, Marlene Antônia Dos Reis, Renata Margarida Etchebehere, Juliana Reis Machado, Rosana Rosa Miranda Corrêa
Preterm birth accounts for nearly one million deaths among children under five years of age, and although its etiopathogenesis is not fully elucidated, ascending intrauterine infection and fetal inflammatory response seem to be the main triggers. The intense inflammatory response mediated by IL-1β, TNF-α, PAF, IFN-γ and IL-6, PGE2 and MMP-1 and MMP-9 causes fetal membrane damage and rupture, increased uterine contractions and biochemical and structural changes in the cervix. Furthermore, preterm neonates have deficient innate and adaptive immune responses characterized by reduced levels of IgG, opsonization and phagocytosis, as well as increased activation of Th1 cells in relation to Th2 cells...
April 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28415675/elevated-microrna-135a-is-associated-with-pulmonary-arterial-hypertension-in-experimental-mouse-model
#15
Hyun-Wook Lee, Sung-Hyun Park
Multiple causes are associated with the complex mechanism of pathogenesis of pulmonary arterial hypertension (PAH), but the molecular pathway in the pathogenesis of PAH is still insufficiently understood. In this study, we investigated epigenetic changes that cause PAH induced by exposure to combined Th2 antigen (Ovalbumin, OVA) and urban particulate matter (PM) in mice. To address that, we focused on the epigenetic mechanism, linked to microRNA (miR)-135a. We found that miR-135a levels were significantly increased, and levels of bone morphogenetic protein receptor type II (BMPR2) which is the target of miR-135a, were significantly decreased in this experimental PAH mouse model...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28408397/the-il-31-il-31-receptor-axis-general-features-and-role-in-tumor-microenvironment
#16
REVIEW
Elisa Ferretti, Anna Corcione, Vito Pistoia
IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed of the exclusive IL-31RA chain and the shared oncostatin M R. Signaling through the IL-31R involves the MAPK, PI3K/AKT and Jak/STAT pathways. Different variants and isoforms of IL-31RA with different signaling activities have been identified. IL-31 is produced predominantly by circulating Th2 lymphocytes and skin-homing CLA(+)CD45RO(+) T cells...
April 13, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28380214/cytokine-profile-in-childhood-onset-systemic-lupus-erythematosus-a-cross-sectional-and-longitudinal-study
#17
A Cavalcanti, R Santos, Z Mesquita, A L B P Duarte, N Lucena-Silva
Childhood-onset systemic lupus erythematosus (cSLE) exhibits an aggressive clinical phenotype and severe complications. This could be due to a pro-inflammatory cytokine milieu. Therefore, we determined plasma levels of Th1 (IL-2, IFN-γ, TNF), Th2 (IL-4), Th17 (IL-17A, IL-6), and Treg (IL-10) cytokines in a cohort of cSLE patients and healthy controls, and we evaluated the association between these cytokines and disease activity. We conducted a cross-sectional study with 51 cSLE patients from two pediatric rheumatology services...
April 3, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28366480/biologic-and-new-therapies-in-asthma
#18
REVIEW
Farnaz Tabatabaian, Dennis K Ledford, Thomas B Casale
Several biologics are currently FDA approved for asthma that target Th2 high patients. Unfortunately, 50% of patients with severe asthma do not fit this phenotype of disease and have fewer effective therapeutic options. In the clinical setting, total IgE, FeNO and peripheral blood eosinophils are important tools in defining Th2 high patients with asthma. However, precise biomarkers to predict better response to one specific Th2 high asthma therapy versus another is lacking. It is important to recognize that none of the current medications targeting the Th2 pathway induces persistent immunomodulation or remission...
May 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/28362822/fasciola-hepatica-reinfection-potentiates-a-mixed-th1-th2-th17-treg-response-and-correlates-with-the-clinical-phenotypes-of-anemia
#19
M Adela Valero, Ignacio Perez-Crespo, Carlos Chillón-Marinas, Messaoud Khoubbane, Carla Quesada, Marta Reguera-Gomez, Santiago Mas-Coma, Manuel Fresno, Núria Gironès
BACKGROUND: Fascioliasis is a severe zoonotic disease of worldwide extension caused by liver flukes. In human fascioliasis hyperendemic areas, reinfection and chronicity are the norm and anemia is the main sign. Herein, the profile of the Th1/Th2/Th17/Treg expression levels is analyzed after reinfection, correlating them with their corresponding hematological biomarkers of morbidity. METHODOLOGY/PRINCIPAL FINDINGS: The experimental design reproduces the usual reinfection/chronicity conditions in human fascioliasis endemic areas and included Fasciola hepatica primo-infected Wistar rats (PI) and rats reinfected at 8 weeks (R8), and at 12 weeks (R12), and negative control rats...
2017: PloS One
https://www.readbyqxmd.com/read/28319473/precision-medicine-in-asthma-the-role-of-bronchial-thermoplasty
#20
Amber J Oberle, Praveen Mathur
PURPOSE OF REVIEW: The inflammatory makeup of severe asthma is heterogeneous. Identification of the predominant cellular endotype via biomarkers can aid in the selection of more advanced therapies. This review is clinically focused on how to use these biomarkers to help select between biologic agents and/or bronchial thermoplasty. RECENT FINDINGS: Several Th2 biomarkers exist for the detection of eosinophilic disease; however, the best biomarker for clinical practice is debatable depending upon local resources...
May 2017: Current Opinion in Pulmonary Medicine
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