Guangyong Huang, Lin Lin, Quanhui Liu, Shixiong Wu, Jiapeng Chen, Rongxing Zhu, Hui You, Cuimin Sun
Sonoporation is a popular membrane disruption technique widely applicable in various fields, including cell therapy, drug delivery, and biomanufacturing. In recent years, there has been significant progress in achieving controlled, high-viability, and high-efficiency cell sonoporation in microfluidics. If the microchannels are too small, especially when scaled down to the cellular level, it still remains a challenge to overcome microchannel clogging, and low throughput. Here, we presented a microfluidic device capable of modulating membrane permeability through oscillating three-dimensional array of microbubbles...
2024: Frontiers in Bioengineering and Biotechnology