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Ottilie von Loeffelholz, Gabor Papai, Radostin Danev, Alexander G Myasnikov, S Kundhavai Natchiar, Isabelle Hazemann, Jean-François Ménétret, Bruno P Klaholz
A current bottleneck in structure determination of macromolecular complexes by cryo electron microscopy (cryo-EM) is the large amount of data needed to obtain high-resolution 3D reconstructions, including through sorting into different conformations and compositions with advanced image processing. Additionally, it may be difficult to visualize small ligands that bind in sub-stoichiometric levels. Volta phase plates (VPP) introduce a phase shift in the contrast transfer and drastically increase the contrast of the recorded low-dose cryo-EM images while preserving high frequency information...
January 11, 2018: Journal of Structural Biology
S Wolf, H Zwickel, C Kieninger, M Lauermann, W Hartmann, Y Kutuvantavida, W Freude, S Randel, C Koos
We demonstrate the generation of higher-order modulation formats using silicon-based inphase/quadrature (IQ) modulators at symbol rates of up to 100 GBd. Our devices exploit the advantages of silicon-organic hybrid (SOH) integration, which combines silicon-on-insulator waveguides with highly efficient organic electro-optic (EO) cladding materials to enable small drive voltages and sub-millimeter device lengths. In our experiments, we use an SOH IQ modulator with a π-voltage of 1.6 V to generate 100 GBd 16QAM signals...
January 8, 2018: Optics Express
Asier Marzo, Tom Corkett, Bruce W Drinkwater
Modern ultrasonic phased-array controllers are electronic systems capable of delaying the transmitted or received signals of multiple transducers. Configurable transmit-receive array systems, capable of electronic steering and shaping of the beam in near real-time, are available commercially, for example, for medical imaging. However, emerging applications, such as ultrasonic haptics, parametric audio, or ultrasonic levitation, require only a small subset of the capabilities provided by the existing controllers...
January 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
Mohammad Javad Kasaei
Due to many environmental and economic influences, the application of Renewable Energy Sources (RESs) such as Photovoltaic (PV), Wind Turbine (WT), Fuel Cell (FC), and Micro Turbine (MT) have quickly been increased. The rapid growth of the RESs has provided both advantages and disadvantages for the power systems. In the side of advantages, lower environmental pollution, less power losses and better power quality and in the side of disadvantages, intermittent nature of RESs and higher uncertainties that cause the variable generation and uncertainty in distribution systems can be mentioned...
December 12, 2017: ISA Transactions
Sara Lospitao-Gómez, Tomás Sebastián-Viana, José M González-Ruíz, Joaquín Álvarez-Rodríguez
OBJECTIVE: The objective of this study was to evaluate the validity of risk detection scales EVARUCI and Norton-MI (modified by INSALUD) to detect critical adult patients with the risk of developing pressure ulcers (PU) in an intensive care unit (ICU). DESIGN: The authors have conducted a descriptive, prospective study at the ICU in their hospital from 2008 to 2014. The evaluations of both scales were registered daily by nurses from the unit. PATIENTS: Adult patients admitted into the ICU...
December 2017: Applied Nursing Research: ANR
Zheng Jiang, Liang Wang, Jiamei Jin
In this work, a novel robotic arm driven by sandwich piezoelectric transducers is proposed. The proposed robotic arm is composed of three arms and four joints. Each arm consists of a sandwich piezoelectric transducer and an H-shaped hollow frame. The sandwich piezoelectric transducer utilizes frictional force to drive the joints on its both sides to rotate simultaneously. The joint between two arms can be driven to rotate in two perpendicular directions by two sandwich piezoelectric transducers. The rotation of joints results in the arm motion...
December 2, 2017: Ultrasonics
Sanghoon Park, Yura Kim, Hyosub Jung, Jun-Young Park, Naesung Lee, Yongho Seo
In this study, we investigated an energy harvesting effect of tensile stress using piezoelectric polymers and flexible electrodes. A chemical-vapor-deposition grown graphene film was transferred onto both sides of the PVDF and P(VDF-TrFE) films simultaneously by means of a conventional wet chemical method. Output voltage induced by sound waves was measured and analyzed when a mechanical tension was applied to the device. Another energy harvester was made with a metallic electrode, where Al and Ag were deposited by using an electron-beam evaporator...
December 11, 2017: Scientific Reports
S H Shah, A Goel, Vpp Selvakumar, S Garg, K Siddiqui, K Kumar
BACKGROUND: Surgical treatment for lung cancer has evolved from pneumonectomy to lobectomy/sleeve resection around the world. Although condemned for poor outcomes, pneumonectomy may still be required in a select group of patients in developing countries. With the better patient selection, optimization of medical comorbidities, better perioperative care; pneumonectomy may show better results. Thus, there is a need to reconsider the role of pneumonectomy in patients with locally advanced lung cancer in the current scenario...
January 2017: Indian Journal of Cancer
Gangqiang Wang, Chaodong Li, Tao Yuan
We describe the design and control of a four legged walking robot, 45 g in weight and 130 mm × 105 mm × 25 mm in size. Each leg consists of two piezoelectric bimorph actuators that are bonded at the free end by a flexure and an end-effector. The robot generates stick-slip locomotion when applying sawtooth shaped voltage signals. Friction between legs and a contact surface is analyzed by using the Coulomb friction model. Locomotion characteristics are measured in several experiments. The robot was driven with frequencies up to 75 Hz, and a maximum velocity of 65 mm/s was obtained at two frequencies: 45 Hz with 190 Vpp driving voltage and 60 Hz with 170 Vpp driving voltage, respectively...
November 2017: Review of Scientific Instruments
Haytham Derbel, Hicham Kobeiter, Guillaume Pizaine, Fourat Ridouani, Alain Luciani, Alessandro Radaelli, William Van der Sterren, Mélanie Chiaradia, Vania Tacher
PURPOSE: To evaluate accuracy of virtual parenchymal perfusion (VPP) algorithm developed for targeting liver cancer during intra-arterial therapy (IAT) using cone-beam CT guidance. MATERIALS AND METHODS: VPP was retrospectively applied to 15 patients who underwent IAT for liver cancer. Virtual territory (VT) was estimated after positioning a virtual injection point on nonselective dual-phase (DP) cone-beam CT images acquired during hepatic arteriography at the same position chosen for selective treatment...
November 27, 2017: Journal of Vascular and Interventional Radiology: JVIR
Juan Carlos Serra Varela, Evi Pecceu, Ian Handel, Jessica Lawrence
Optimal chemotherapy protocols for high-risk mast cell tumours (MCTs) are unknown. The purpose of this study was to determine the tolerability and toxicity profile of a rapidly escalating vinblastine and prednisolone protocol (VPP) in which 3.00 mg/m(2) was administered once 7 days apart: at day 14 and at day 21. Dogs with chemotherapy-naïve MCTs presenting to the Oncology Service of a single institution were prospectively enrolled to receive escalating vinblastine, and haematology and a standardised quality-of-life questionnaire were assessed prior to each dosage...
November 2016: Veterinary Medicine and Science
Chun-Hao Huang, Kin Fong Lei
In vitro cell culture device was developed for the investigation of inhibition effect of cell colonies using alternating electric field. Cancer cells were cultured in 3D hydrogel and cell colonies, or called tumor spheroids, were gradually formed in the culture device. During the culture course, alternating electric field was applied and the conditions were investigated to optimize the inhibition effect of cell colonies. Results showed that electric field at frequency of 130 kHz and 0.5 Vpp was the minimal effective conditions of the inhibition of cell colonies...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Hidetoshi Miyazaki, Teppei Nakamura, Kohji Ohki, Katsuya Nagai
The bioactive peptides Ile-Pro-Pro (IPP) and Val-Pro-Pro (VPP) are believed to improve blood pressure and arterial function. To gain a better understanding of the mechanisms underlying the action of these peptides, we investigated their effects upon autonomic neurotransmission and blood pressure in spontaneously hypertensive rats (SHR). Both IPP and VPP caused a significant reduction in cutaneous arterial sympathetic nerve activity (CASNA) and reduced mean arterial pressure (MAP); however, both of these effects were eliminated following sub-diaphragmatic vagotomy...
September 29, 2017: Autonomic Neuroscience: Basic & Clinical
M Ali Fadel, Reem H El-Gebaly, Shaimaa A Mohamed, Ashraf M M Abdelbacki
Isolated Agrobacterium tumefaciens was exposed to different extremely low frequencies of square amplitude modulated waves (QAMW) from two generators to determine the resonance frequency that causes growth inhibition. The carrier was 10 MHz sine wave with amplitude ±10 Vpp which was modulated by a second wave generator with a modulation depth of ± 2Vpp and constant field strength of 200 V/m at 28 °C. The exposure of A. tumefaciens to 1.0 Hz QAMW for 90 min inhibited the bacterial growth by 49.2%. In addition, the tested antibiotics became more effective against A...
December 9, 2017: Biochemical and Biophysical Research Communications
Jiafeng Ruan, Tao Yuan, Yuepeng Pang, Xinbo Xu, Junhe Yang, Wenbin Hu, Cheng Zhong, Zi-Feng Ma, Xuanxuan Bi, Shiyou Zheng
Red phosphorus (P) is considered to be one of the most attractive anodic materials for lithium-ion batteries (LIBs) due to its high theoretical capacity of 2596 mAh g(-1). However, intrinsic characteristics such as the poor electronic conductivity and large volume expansion at lithiation impede the development of red P. Here, we design a new strategy to embed red P particles into a cross-link-structural carbon film (P-C film), in order to improve the electronic conductivity and accommodate the volume expansion...
October 18, 2017: ACS Applied Materials & Interfaces
Maria Heenemann, Christian Heine, Michael Hävecker, Annette Trunschke, Robert Schlögl
We have investigated electronic and catalytic modifications of the p-type semiconducting selective oxidation catalyst vanadyl pyrophosphate (VPP) for propane oxidation in the presence and absence of steam. Steam changes propane conversion only slightly, but increases the selectivity toward oxygenates (acrylic acid, acetic acid) and the olefin propylene resulting in reduced selectivity of the undesired total oxidation products CO and CO2. Contact-free in operando microwave conductivity measurements at 0.1 MPa revealed that the modified catalytic performance is accompanied by a reduced electrical conductivity...
October 5, 2017: Journal of Physical Chemistry. B
Xiao Fan, Lingyun Zhao, Chuan Liu, Jin-Can Zhang, Kelong Fan, Xiyun Yan, Hai-Lin Peng, Jianlin Lei, Hong-Wei Wang
Volta phase plate (VPP) is a recently developed transmission electron microscope (TEM) apparatus that can significantly enhance the image contrast of biological samples in cryoelectron microscopy, and therefore provide the possibility to solve structures of relatively small macromolecules at high-resolution. In this work, we performed theoretical analysis and found that using phase plate on objective lens spherical aberration (Cs)-corrected TEM may gain some interesting optical properties, including the over-focus imaging of macromolecules...
September 8, 2017: Structure
Jackie S Huberman, Samantha J Dawson, Meredith L Chivers
Sexual response is a dynamic process, though there is limited knowledge of the time course and relationships among its psychological and physiological components. To address this gap, we concurrently assessed self-reported sexual arousal, genital temperature (with thermography), and genital vasocongestion (with vaginal photoplethysmography [VPP] or penile plethysmography [PPG]) during sexual and nonsexual films in 28 androphilic women (attracted to men) and 27 gynephilic men (attracted to women). Men and women had similarly strong agreement between subjective and genital responses (sexual concordance) with thermography, but this agreement was stronger in men than women with PPG/VPP...
September 15, 2017: Biological Psychology
Ya-Bin Sun, Xiao-Xiao Lin, Wen Ye, Ning Wang, Jin-Yan Wang, Fei Luo
Empathizing with another's suffering is important in social interactions. Empathic behavior is selectively elicited from genuine, meaningful pain but not from fake, meaningless scenarios. However, the brain's screening mechanism of false information from meaningful events and the time course for the screening process remains unclear. Using EEG combined with principle components analysis (PCA) techniques, here we compared temporal neurodynamics between the observation of pain and no-pain pictures as well as between true (painful expressions and needle-penetrated arms) and false (needle-penetrated faces with neutral expressions) pain pictures...
September 13, 2017: Scientific Reports
Bei Zhao, Xingye Cui, Wei Ren, Feng Xu, Ming Liu, Zuo-Guang Ye
A microfluidic chip with a controllable and integrated piezoelectric pump was proposed and demonstrated, where the pump was designed as a micro-actuator based on polyvinylidene fluoride (PVDF) organic piezoelectric film. In this case, the pump should integrate with the microfluidics device very well into one chip. The flow rate can be precisely controlled in the range of 0-300 µl/min for water by tuning the Vpp and frequency of Alternating Current (AC) voltage applied on the diaphragm. To analyze the relationship between the flow rate and the deflection of diaphragm, the deformations of diaphragm at different voltages were researched...
September 12, 2017: Scientific Reports
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