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https://www.readbyqxmd.com/read/29067202/tolerability-of-a-rapid-escalation-vinblastine-prednisolone-protocol-in-dogs-with-mast-cell-tumours
#1
Juan Carlos Serra Varela, Evi Pecceu, Ian Handel, Jessica Lawrence
Optimal chemotherapy protocols for high-risk mast cell tumours (MCTs) are unknown. The purpose of this study was to determine the tolerability and toxicity profile of a rapidly escalating vinblastine and prednisolone protocol (VPP) in which 3.00 mg/m(2) was administered once 7 days apart: at day 14 and at day 21. Dogs with chemotherapy-naïve MCTs presenting to the Oncology Service of a single institution were prospectively enrolled to receive escalating vinblastine, and haematology and a standardised quality-of-life questionnaire were assessed prior to each dosage...
November 2016: Veterinary Medicine and Science
https://www.readbyqxmd.com/read/29060301/in-vitro-cell-culture-study-of-the-conditions-of-inhibition-effect-of-tumors-under-alternating-electric-field
#2
Chun-Hao Huang, Kin Fong Lei
In vitro cell culture device was developed for the investigation of inhibition effect of cell colonies using alternating electric field. Cancer cells were cultured in 3D hydrogel and cell colonies, or called tumor spheroids, were gradually formed in the culture device. During the culture course, alternating electric field was applied and the conditions were investigated to optimize the inhibition effect of cell colonies. Results showed that electric field at frequency of 130 kHz and 0.5 Vpp was the minimal effective conditions of the inhibition of cell colonies...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28988803/effects-of-the-bioactive-peptides-ile-pro-pro-and-val-pro-pro-upon-autonomic-neurotransmission-and-blood-pressure-in-spontaneously-hypertensive-rats
#3
Hidetoshi Miyazaki, Teppei Nakamura, Kohji Ohki, Katsuya Nagai
The bioactive peptides Ile-Pro-Pro (IPP) and Val-Pro-Pro (VPP) are believed to improve blood pressure and arterial function. To gain a better understanding of the mechanisms underlying the action of these peptides, we investigated their effects upon autonomic neurotransmission and blood pressure in spontaneously hypertensive rats (SHR). Both IPP and VPP caused a significant reduction in cutaneous arterial sympathetic nerve activity (CASNA) and reduced mean arterial pressure (MAP); however, both of these effects were eliminated following sub-diaphragmatic vagotomy...
September 29, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28988110/biophysical-control-of-the-growth-of-agrobacterium-tumefaciens-using-extremely-low-frequency-electromagnetic-waves-at-resonance-frequency
#4
M Ali Fadel, Reem H El-Gebaly, Shaimaa A Mohamed, Ashraf M M Abdelbacki
Isolated Agrobacterium tumefaciens was exposed to different extremely low frequencies of square amplitude modulated waves (QAMW) from two generators to determine the resonance frequency that causes growth inhibition. The carrier was 10 MHz sine wave with amplitude ±10 Vpp which was modulated by a second wave generator with a modulation depth of ± 2Vpp and constant field strength of 200 V/m at 28 °C. The exposure of A. tumefaciens to 1.0 Hz QAMW for 90 min inhibited the bacterial growth by 49.2%. In addition, the tested antibiotics became more effective against A...
December 9, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28960055/red-phosphorus-embedded-cross-link-structural-carbon-films-as-flexible-anodes-for-highly-reversible-li-ion-storage
#5
Jiafeng Ruan, Tao Yuan, Yuepeng Pang, Xinbo Xu, Junhe Yang, Wenbin Hu, Cheng Zhong, Zi-Feng Ma, Xuanxuan Bi, Shiyou Zheng
Red phosphorus (P) is considered to be one of the most attractive anodic materials for lithium-ion batteries (LIBs) due to its high theoretical capacity of 2596 mAh g(-1). However, intrinsic characteristics such as the poor electronic conductivity and large volume expansion at lithiation impede the development of red P. Here, we design a new strategy to embed red P particles into a cross-link-structural carbon film (P-C film), in order to improve the electronic conductivity and accommodate the volume expansion...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28949537/influence-of-steam-on-a-vanadyl-pyrophosphate-catalyst-during-propane-oxidation
#6
Maria Heenemann, Christian Heine, Michael Hävecker, Annette Trunschke, Robert Schlögl
We have investigated electronic and catalytic modifications of the p-type semiconducting selective oxidation catalyst vanadyl pyrophosphate (VPP) for propane oxidation in the presence and absence of steam. Steam changes propane conversion only slightly, but increases the selectivity toward oxygenates (acrylic acid, acetic acid) and the olefin propylene resulting in reduced selectivity of the undesired total oxidation products CO and CO2. Contact-free in operando microwave conductivity measurements at 0.1 MPa revealed that the modified catalytic performance is accompanied by a reduced electrical conductivity...
October 5, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28943337/near-atomic-resolution-structure-determination-in-over-focus-with-volta-phase-plate-by-cs-corrected-cryo-em
#7
Xiao Fan, Lingyun Zhao, Chuan Liu, Jin-Can Zhang, Kelong Fan, Xiyun Yan, Hai-Lin Peng, Jianlin Lei, Hong-Wei Wang
Volta phase plate (VPP) is a recently developed transmission electron microscope (TEM) apparatus that can significantly enhance the image contrast of biological samples in cryoelectron microscopy, and therefore provide the possibility to solve structures of relatively small macromolecules at high-resolution. In this work, we performed theoretical analysis and found that using phase plate on objective lens spherical aberration (Cs)-corrected TEM may gain some interesting optical properties, including the over-focus imaging of macromolecules...
September 8, 2017: Structure
https://www.readbyqxmd.com/read/28919258/examining-the-time-course-of-genital-and-subjective-sexual-responses-in-women-and-men-with-concurrent-plethysmography-and-thermography
#8
Jackie S Huberman, Samantha J Dawson, Meredith L Chivers
Sexual response is a dynamic process, though there is limited knowledge of the time course and relationships among its psychological and physiological components. To address this gap, we concurrently assessed self-reported sexual arousal, genital temperature (with thermography), and genital vasocongestion (with vaginal photoplethysmography [VPP] or penile plethysmography [PPG]) during sexual and nonsexual films in 28 androphilic women (attracted to men) and 27 gynephilic men (attracted to women). Men and women had similarly strong agreement between subjective and genital responses (sexual concordance) with thermography, but this agreement was stronger in men than women with PPG/VPP...
September 15, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28904379/a-screening-mechanism-differentiating-true-from-false-pain-during-empathy
#9
Ya-Bin Sun, Xiao-Xiao Lin, Wen Ye, Ning Wang, Jin-Yan Wang, Fei Luo
Empathizing with another's suffering is important in social interactions. Empathic behavior is selectively elicited from genuine, meaningful pain but not from fake, meaningless scenarios. However, the brain's screening mechanism of false information from meaningful events and the time course for the screening process remains unclear. Using EEG combined with principle components analysis (PCA) techniques, here we compared temporal neurodynamics between the observation of pain and no-pain pictures as well as between true (painful expressions and needle-penetrated arms) and false (needle-penetrated faces with neutral expressions) pain pictures...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28900226/a-controllable-and-integrated-pump-enabled-microfluidic-chip-and-its-application-in-droplets-generating
#10
Bei Zhao, Xingye Cui, Wei Ren, Feng Xu, Ming Liu, Zuo-Guang Ye
A microfluidic chip with a controllable and integrated piezoelectric pump was proposed and demonstrated, where the pump was designed as a micro-actuator based on polyvinylidene fluoride (PVDF) organic piezoelectric film. In this case, the pump should integrate with the microfluidics device very well into one chip. The flow rate can be precisely controlled in the range of 0-300 µl/min for water by tuning the Vpp and frequency of Alternating Current (AC) voltage applied on the diaphragm. To analyze the relationship between the flow rate and the deflection of diaphragm, the deformations of diaphragm at different voltages were researched...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28887362/resolving-bipolar-electrogram-voltages-during-atrial-fibrillation-using-omnipolar-mapping
#11
Shouvik K Haldar, Karl Magtibay, Andreu Porta-Sanchez, Stéphane Massé, Nicholas Mitsakakis, Patrick F H Lai, Mohammed Ali Azam, John Asta, Marjan Kusha, Paul Dorian, Andrew C T Ha, Vijay Chauhan, D Curtis Deno, Kumaraswamy Nanthakumar
BACKGROUND: Low-voltage-guided substrate modification is an emerging strategy in atrial fibrillation (AF) ablation. A major limitation to contemporary bipolar electrogram (EGM) analysis in AF is the resultant lower peak-to-peak voltage (Vpp) from variations in wavefront direction relative to electrode orientation and from fractionation and collision events. We aim to compare bipole Vpp with novel omnipolar peak-to-peak voltages (Vmax) in sinus rhythm (SR) and AF. METHODS AND RESULTS: A high-density fixed multielectrode plaque was placed on the epicardial surface of the left atrium in dogs...
September 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28851892/determining-the-geographical-origin-of-common-buckwheat-from-china-by-multivariate-analysis-based-on-mineral-elements-amino-acids-and-vitamins
#12
Qiang Zhang, Jian-Guo Xu
This study aimed to establish a method for distinguishing the geographical origin of common buckwheat from Inner Mongolia, Shanxi and Shaanxi Provinces in China. Three chemical families including mineral elements, vitamins and amino acids of 48 samples from different geographical origins were analyzed by principal component analysis (PCA), cluster analysis (CA) and linear discriminate analysis (LDA) for this purpose. LDA clearly discriminated the geographical origin of common buckwheat samples grown in three regions, and gave a high correct classification rate of 95...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28813865/template-model-inspired-leg-force-feedback-based-control-can-assist-human-walking
#13
Guoping Zhao, Maziar Sharbafi, Mark Vlutters, Edwin van Asseldonk, Andre Seyfarth
We present a novel control approach for assistive lower-extremity exoskeletons. In particular, we implement a virtual pivot point (VPP) template model inspired leg force feedback based controller on a lower-extremity powered exoskeleton (LOPES II) and demonstrate that it can effectively assist humans during walking. It has been shown that the VPP template model is capable of stabilizing the trunk and reproduce a human-like hip torque during the stance phase of walking. With leg force and joint angle feedback inspired by the VPP template model, our controller provides hip and knee torque assistance during the stance phase...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811112/exogenous-testosterone-affects-early-threat-processing-in-socially-anxious-and-healthy-women
#14
Jacobien M van Peer, Dorien Enter, Henk van Steenbergen, Philip Spinhoven, Karin Roelofs
Testosterone plays an important role in social threat processing. Recent evidence suggests that testosterone administration has socially anxiolytic effects, but it remains unknown whether this involves early vigilance or later, more sustained, processing-stages. We investigated the acute effects of testosterone administration on social threat processing in 19 female patients with Social Anxiety Disorder (SAD) and 19 healthy controls. Event-related potentials (ERPs) were recorded during an emotional Stroop task with subliminally presented faces...
August 12, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28759054/the-association-between-retinal-vein-pulsation-pressure-and-optic-disc-haemorrhages-in-glaucoma
#15
Dong An, Philip House, Christopher Barry, Andrew Turpin, Allison M McKendrick, Balwantray C Chauhan, Siobhan Manners, Stuart L Graham, Dao-Yi Yu, William H Morgan
PURPOSE: To explore the potential relationship between optic disc haemorrhage, venous pulsation pressure (VPP), ocular perfusion pressures and visual field change in glaucomatous and glaucoma suspect eyes. MATERIALS AND METHODS: This prospective observational study examined 155 open angle glaucoma or glaucoma suspect eyes from 78 patients over 5 years. Patients were followed with 3 monthly non-mydriatic disc photographs, 6 monthly standard automated perimetry and annual ophthalmodynamometry...
2017: PloS One
https://www.readbyqxmd.com/read/28743457/mental-imagery-of-face-enhances-face-sensitive-event-related-potentials-to-ambiguous-visual-stimuli
#16
Lingxi Lu, Changxin Zhang, Liang Li
Visual mental imagery forms mental representations of visual objects when correspondent stimuli are absent and shares some characters with visual perception. Both the vertex-positive-potential (VPP) and N170 components of event-related potentials (ERPs) to visual stimuli have a remarkable preference to faces. This study investigated whether visual mental imagery modulates the face-sensitive VPP and/or N170 components. The results showed that with significantly larger amplitudes under the face-imagery condition than the house-imagery condition, the VPP and P2 responses, but not the N170 component, were elicited by phase-randomized ambiguous stimuli...
July 22, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28680038/a-high-speed-electro-optic-triple-microring-resonator-modulator
#17
Jianxun Hong, Feng Qiu, Xiaoyang Cheng, Andrew M Spring, Shiyoshi Yokoyama
The coupling intensity modulator based on a triple-microring structure was proposed and numerically investigated for a high speed and a low bit error ratio (BER) operation. The modulator consists of a dual-microring optical cavity and a gate-microring energy feedback path. The optical cavity ensures a high energy storing efficiency, and the feedback path enables modulation with little intracavity energy decay. The bandwidth of 103 GHz and modulation depth of 6.2 dB at 2.0 Vpp were theoretically verified by the analysis of the sinusoidal modulation performance...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28667950/a-novel-large-thrust-weight-ratio-v-shaped-linear-ultrasonic-motor-with-a-flexible-joint
#18
Xiaoniu Li, Zhiyuan Yao, Mojian Yang
A novel large thrust-weight ratio V-shaped linear ultrasonic motor with a flexible joint is proposed in this paper. The motor is comprised of a V-shaped transducer, a slider, a clamp, and a base. The V-shaped transducer consists of two piezoelectric beams connected through a flexible joint to form an appropriate coupling angle. The V-shaped motor is operated in the coupled longitudinal-bending mode. Longitudinal and bending movements are transferred by the flexible joint between the two beams. Compared with the coupled longitudinal-bending mode of the single piezoelectric beam or the symmetrical and asymmetrical modes of the previous V-shaped transducer, the coupled longitudinal-bending mode of the V-shaped transducer with a flexible joint provides higher vibration efficiency and more convenient mode conformance adjustment...
June 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28594117/serum-anti-phenolic-glycolipid-1-iga-correlates-to-igm-isotype-in-leprosy-patients-a-possible-candidate-for-seroepidemiological-surveys
#19
Alexandre C de Macedo, Juliana A Guimarães, Raphael O Rodrigues, Thiago D V Araújo, Clodis M Tavares, Paula B Cabral, Maria Isabel de Moraes-Pinto, Aparecida T Nagao-Dias
OBJECTIVE: The aim of this study was to compare serum anti-phenolic glycolipid-1 IgA, IgG, and IgM levels in leprosy patients and controls. METHOD: Analysis of anti-PGL-1 IgA, IgG, or IgM in serum samples from multibacillary (MB, n=32) and paucibacillary (PB, n=22) leprosy patients, and in non-endemic controls (n=17), using an indirect enzyme-linked immunosorbent assay. RESULTS: A strong correlation between serum IgM and IgA isotypes was found (r=...
June 8, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28553963/frequency-dependent-stability-of-cnt-joule-heaters-in-ionizable-media-and-desalination-processes
#20
Alexander V Dudchenko, Chuxiao Chen, Alexis Cardenas, Julianne Rolf, David Jassby
Water shortages and brine waste management are increasing challenges for coastal and inland regions, with high-salinity brines presenting a particularly challenging problem. These high-salinity waters require the use of thermally driven treatment processes, such as membrane distillation, which suffer from high complexity and cost. Here, we demonstrate how controlling the frequency of an applied alternating current at high potentials (20 Vpp) to a porous thin-film carbon nanotube (CNT)/polymer composite Joule heating element can prevent CNT degradation in ionizable environments such as high-salinity brines...
July 2017: Nature Nanotechnology
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