keyword
https://read.qxmd.com/read/38462189/polydimethylsiloxane-dialysis-passive-sampler-monitoring-of-chlorinated-solvent-contaminated-sites-a-field-study
#21
JOURNAL ARTICLE
Chenju Liang, Chi-Wei Wang
The complexity of the subsurface contaminated by chlorinated solvents such as trichloroethylene (TCE) makes it challenging to gain a complete understanding of contamination distribution and establish a conceptual site model (CSM). High-resolution vertical contaminant concentration profiling across both the unsaturated zone and the saturated aquifer is desirable for mapping the distribution of contamination. A Fick's law-based polydimethylsiloxane (PDMS) dialysis passive sampler was developed and evaluated on a field scale for its potential application...
March 8, 2024: Chemosphere
https://read.qxmd.com/read/38455046/using-protein-geometry-to-optimize-cytotoxicity-and-the-cytokine-window-of-a-ror1-specific-t-cell-engager
#22
JOURNAL ARTICLE
Xueyuan Zhou, Felix Klaus Geyer, Dominic Happel, Jeffrey Takimoto, Harald Kolmar, Brian Rabinovich
T cell engaging bispecific antibodies have shown clinical proof of concept for hematologic malignancies. Still, cytokine release syndrome, neurotoxicity, and on-target-off-tumor toxicity, especially in the solid tumor setting, represent major obstacles. Second generation TCEs have been described that decouple cytotoxicity from cytokine release by reducing the apparent binding affinity for CD3 and/or the TAA but the results of such engineering have generally led only to reduced maximum induction of cytokine release and often at the expense of maximum cytotoxicity...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38447712/c5b-9-promotes-ferritinophagy-leading-to-ferroptosis-in-renal-tubular-epithelial-cells-of-trichloroethylene-sensitized-mice
#23
JOURNAL ARTICLE
Zhibing Liu, Sifan Zhou, Feng Wang, Haibo Xie, Jiaxiang Zhang, Changhao Wu, Dexiang Xu, Qixing Zhu
Trichloroethylene (TCE) is a common environmental contaminant that can cause a severe allergic reaction called TCE hypersensitivity syndrome, which often implicates the patient's kidneys. Our previous study revealed that C5b-9-induced tubular ferroptosis is involved in TCE-caused kidney damage. However, the study did not explain how tubule-specific C5b-9 causes free iron overload, a key event in ferroptosis. Here, we aimed to explore the role of NCOA4-mediated ferritinophagy in C5b-9-induced iron overload and ferroptosis in TCE-sensitized mice...
March 4, 2024: Science of the Total Environment
https://read.qxmd.com/read/38431522/treatment-pattern-healthcare-resource-utilization-and-symptom-burden-among-patients-with-triple-class-exposed-multiple-myeloma-a-population-based-cohort-study
#24
JOURNAL ARTICLE
Hira Mian, Hsien Seow, Gregory R Pond, Anastasia Gayowsky, Ronan Foley, Amaris Balistky, Mohammed Ebraheem, Christopher Cipkar, Hyra Sapru, Ghulam Rehman Mohyuddin, Samer Al Hadidi, Alissa Visram
PURPOSE: This study aims to describe the treatment patterns, outcomes, health care utilization and symptom burden of triple class exposed (TCE) relapsed/refractory patents with multiple myeloma (MM) receiving a subsequent line of treatment (LOT). METHODS: This is a retrospective observational cohort study using administrative databases in Ontario, Canada. Outcomes were captured for TCE patients receiving a subsequent LOT and included: treatment regimen details, time to next treatment (TTNT), overall survival (OS), health care utilization, palliative care referral, and patient reported symptoms...
February 14, 2024: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38428797/hydraulic-containment-of-tce-contaminated-groundwater-using-pulsed-pump-and-treat-performance-evaluation-and-vapor-intrusion-risk-assessment
#25
JOURNAL ARTICLE
Min Seo Bae, Jae-Hyun Kim, Soonjae Lee
Remedial actions for groundwater contamination such as containment, in-situ remediation, and pump-and-treat have been developed. This study investigates the hydraulic containment of Trichloroethylene (TCE) contaminated groundwater by using pulsed pump-and-treat technology. The hypothetical research site assumed the operation of pulsed pump-and-treat to manage groundwater contaminated with 0.1 mg/L of TCE. at the pump-and-treat facility. Numerical models, employing MODFLOW and MT3DMS for groundwater flow and contamination simulations, were used for case studies to evaluate the performance and risks of pump-and-treat operation strategies...
February 28, 2024: Environmental Pollution
https://read.qxmd.com/read/38427258/evaluating-motor-dysfunction-and-oxidative-stress-induced-by-trichloroethylene-in-wistar-rats
#26
JOURNAL ARTICLE
Rajnish Srivastava, Kanupriya Chauhan, Ramaish Sharma
Trichloroethylene, a chlorinated solvent widely used as a degreasing agent, is a common environmental contaminant. Emerging evidence suggests that chronic exposure to trichloroethylene (TCE) contributes to the development of Parkinson's disease (PD). TCE induced LRRK2 kinase activity in the rat brain and produced a significant dopaminergic lesion in the nigrostriatal tract with elevated oxidative stress. Here we have utilized TCE-induced PD model for the assessment of test drug. Oral gavage administration of TCE at a dose of 1000 mg/kg/day for 6 weeks was utilized to induced PD...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38421887/ex-vivo-efficacy-of-sar442257-anti-cd38-trispecific-t-cell-engager-in-multiple-myeloma-relapsed-after-daratumumab-and-bcma-targeted-therapies
#27
JOURNAL ARTICLE
Alana L Keller, Lauren T Reiman, Olivia Perez de Acha, Sarah E Parzych, Peter A Forsberg, Peter S Kim, Kamlesh Bisht, Hongfang Wang, Helgi Van de Velde, Daniel W Sherbenou
T cell engaging antibodies (TCEs) are showing promising efficacy in relapsed/refractory multiple myeloma (MM), even in patients that relapsed after BCMA targeted therapy. MM patients may have compromised T cell health unaccounted for by preclinical models. Here, we use Myeloma Drug Sensitivity Testing (My-DST) for ex vivo measurement of anti-MM cytotoxicity for the trispecific CD38/CD28xCD3 TCE SAR442257 through activation of the patients' own endogenous T cells to inform clinical development of the compound in MM...
February 29, 2024: Cancer Res Commun
https://read.qxmd.com/read/38421193/epidrugs-alternative-chemotherapy-targeting-theileria-annulata-schizont-stage-parasites
#28
JOURNAL ARTICLE
Sonam Kamble, Sakshi Singh, Akash Suresh, Siva Singothu, Debabrata Dandesena, Vasundhra Bhandari, Paresh Sharma
The growing emergence of resistance to current anti-theilerial agents necessitates the exploration of alternative approaches to drug discovery. This study evaluated the antiparasitic efficacy of 148 compounds derived from an epigenetic inhibitor library against the schizont stage of a Theileria annulata -infected cell line. Initial screening at a concentration of 10 µM identified 27 compounds exhibiting promising anti-theilerial activity. Further investigation, including determination of the 50% inhibitory concentration (IC50 ) and host cell cytotoxicity assay, highlighted seven highly effective compounds (SAHA, BVT-948, Trichostatin A, Methylstat, Plumbagin, Ryuvidine, and TCE-5003) against T...
February 29, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38417369/surfactant-enhanced-persulfate-system-for-the-synergistic-oxidation-and-reduction-of-mixed-chlorinated-hydrocarbons
#29
JOURNAL ARTICLE
Zhiqiang Xu, Lankun Cai, Zhengyuan Zhou, Rumin Yang, Guilu Zeng, Rongbing Fu, Shuguang Lyu
Surfactant-enhanced in-situ chemical oxidation (S-ISCO) is widely applied in soil and groundwater remediation. However, the role of surfactants in the reactive species (RSs) transformation remains inadequately explored. This work introduced nonionic surfactant Tween-80 (TW-80) into a nano zero-valent iron (nZVI) activated persulfate (PS) system. The findings indicate that PS/nZVI/TW-80 system can realize the concurrent removal of trichloroethylene (TCE), tetrachloroethene (PCE), and carbon tetrachloride (CT), whereas CT cannot be eliminated without TW-80 presence...
February 27, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38402374/comparative-efficacy-of-talquetamab-vs-current-treatments-in-the-locommotion-and-momment-studies-in-patients-with-triple-class-exposed-relapsed-refractory-multiple-myeloma
#30
JOURNAL ARTICLE
Hermann Einsele, Philippe Moreau, Nizar Bahlis, Manisha Bhutani, Laure Vincent, Lionel Karlin, Aurore Perrot, Hartmut Goldschmidt, Niels W C J van de Donk, Enrique M Ocio, Joaquin Martinez-Lopez, Paula Rodríguez-Otero, Dominik Dytfeld, Joris Diels, Vadim Strulev, Imene Haddad, Thomas Renaud, Eric Ammann, Jedelyn Cabrieto, Nolen Perualila, Ryan Gan, Youyi Zhang, Trilok Parekh, Claire Albrecht, Katja Weisel, Maria-Victoria Mateos
INTRODUCTION: Talquetamab, a bispecific antibody targeting GPRC5D × CD3, is approved for the treatment of patients with triple-class -exposed (TCE) relapsed/refractory multiple myeloma (RRMM) on the basis of the results from the phase I/II MonumenTAL-1 trial. The relative effectiveness of talquetamab vs. real-world physician's choice of therapy (RWPC) was assessed using adjusted comparisons. METHODS: An external control arm for MonumenTAL-1 (subcutaneously administered talquetamab 0...
February 24, 2024: Advances in Therapy
https://read.qxmd.com/read/38393240/adsorption-behavior-and-kinetics-of-1-4-dioxane-by-carbon-aerogel
#31
JOURNAL ARTICLE
Tianyu Lu, Huihui Huang, Guifen Lv, Fei Li, Ren-Jie Song, Yuting Cai
1,4-dioxane is a potential carcinogen in water and is difficult to deal with due to its robust cycloether bond and complete miscibility with water. To remove 1,4-dioxane in an economically viable and environmentally friendly way, a series of carbon aerogels were synthesized as adsorbents for 1,4-dioxane. The experiment results showed that adsorption performances were closely related to the preparation conditions of carbon aerogels, such as the molar ratio, heating rate, pyrolysis temperature and residence time, which were carefully controlled...
February 12, 2024: Toxics
https://read.qxmd.com/read/38390196/effect-of-traditional-chinese-fitness-exercises-on-bone-mineral-density-in-postmenopausal-women-a-network-meta-analysis-of-randomized-controlled-trials
#32
Shijie Liu, Sijun Wu, Juancai Qi, Lin Wang
UNLABELLED: We aimed to evaluate the clinical efficacy of five traditional Chinese fitness exercises (Baduanjin, Taijiquan, Wuqinxi, Yijinjing, and Liuzijue), as well as their efficacy when combined with drug therapy, in the treatment of decreased bone mineral density in postmenopausal women. METHODS: This study strictly followed the evaluation guidelines of PRISMA and followed the "PICOS" principle outlined in the Cochrane Handbook. We performed a systematic search on Web of Science, Springer Link, Scopus, EMBASE, EBSCO, PubMed, the Cochrane Library, CNKI, Wanfang, CBMdisc, and the VIP Database, and we targeted RCTs studying the effect of TCE on BMD in postmenopausal women published prior to September 2023...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38389433/dry-cleaning-chemicals-and-a-cluster-of-parkinson-s-disease-and-cancer-a-retrospective-investigation
#33
JOURNAL ARTICLE
E Ray Dorsey, Dan Kinel, Meghan E Pawlik, Maryam Zafar, Samantha E Lettenberger, Madeleine Coffey, Peggy Auinger, Kevin L Hylton, Carol W Shaw, Jamie L Adams, Richard Barbano, Melanie K Braun, Heidi B Schwarz, B Paige Lawrence, Karl Kieburtz, Caroline M Tanner, Briana R de Miranda, Samuel M Goldman
BACKGROUND: Environmental exposure to trichloroethylene (TCE), a carcinogenic dry-cleaning chemical, may be linked to Parkinson's disease (PD). OBJECTIVE: The objective of this study was to determine whether PD and cancer were elevated among attorneys who worked near a contaminated site. METHODS: We surveyed and evaluated attorneys with possible exposure and assessed a comparison group. RESULTS: Seventy-nine of 82 attorneys (96...
February 23, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38382292/unveiling-the-inhibitory-mechanisms-of-chromium-exposure-on-microbial-reductive-dechlorination-kinetics-and-microbial-responses
#34
JOURNAL ARTICLE
Zheng-Tao Li, Xin Song, Songhu Yuan, He-Ping Zhao
Chromium and organochlorine solvents, particularly trichloroethene (TCE), are pervasive co-existing contaminants in subsurface aquifers due to their extensive industrial use and improper disposal practices. In this study, we investigated the microbial dechlorination kinetics under different TCE-Cr(Ⅲ/VI) composite pollution conditions and elucidated microbial response mechanisms based on community shift patterns and metagenomic analysis. Our results revealed that the reductive dechlorinating consortium had high resistance to Cr(III) but extreme sensitivity to Cr(VI) disturbance, resulting in a persistent inhibitory effect on subsequent dechlorination...
February 16, 2024: Water Research
https://read.qxmd.com/read/38364580/electrokinetic-bioremediation-of-trichloroethylene-and-cr-as-co-contaminated-soils-with-elevated-sulfate
#35
JOURNAL ARTICLE
Qizheng Cai, Chongwen Shi, Zixuan Cao, Zhengtao Li, He-Ping Zhao, Songhu Yuan
Co-contaminants and complex subsurface conditions pose great challenges to site remediation. This study demonstrates the potential of electrokinetic bioremediation (EK-BIO) in treating co-contaminants of chlorinated solvents and heavy metals in low-permeability soils with elevated sulfate. EK-BIO columns were filled with field soils, and were fed by the electrolyte containing 20 mg/L trichloroethylene (TCE), 250 μM Cr(VI), 25 μM As(III), 10 mM lactate, and 10 mM sulfate...
February 14, 2024: Journal of Hazardous Materials
https://read.qxmd.com/read/38354229/engineered-t-cells-secreting-anti-bcma-t-cell-engagers-control-multiple-myeloma-and-promote-immune-memory-in-vivo
#36
JOURNAL ARTICLE
Laura Díez-Alonso, Aïda Falgas, Javier Arroyo-Ródenas, Paola A Romencín, Alba Martínez, Marina Gómez-Rosel, Belén Blanco, Anaïs Jiménez-Reinoso, Andrea Mayado, Alba Pérez-Pons, Óscar Aguilar-Sopeña, Ángel Ramírez-Fernández, Alejandro Segura-Tudela, Lorena Perez-Amill, Antonio Tapia-Galisteo, Carmen Domínguez-Alonso, Laura Rubio-Pérez, Maria Jara, Francesc Solé, Oana Hangiu, Laura Almagro, Ángela Albitre, Petronila Penela, Laura Sanz, Eduardo Anguita, Antonio Valeri, Almudena García-Ortiz, Paula Río, Manel Juan, Joaquín Martínez-López, Pedro Roda-Navarro, Beatriz Martín-Antonio, Alberto Orfao, Pablo Menéndez, Clara Bueno, Luis Álvarez-Vallina
Multiple myeloma is the second most common hematological malignancy in adults and remains an incurable disease. B cell maturation antigen (BCMA)-directed immunotherapy, including T cells bearing chimeric antigen receptors (CARs) and systemically injected bispecific T cell engagers (TCEs), has shown remarkable clinical activity, and several products have received market approval. However, despite promising results, most patients eventually become refractory and relapse, highlighting the need for alternative strategies...
February 14, 2024: Science Translational Medicine
https://read.qxmd.com/read/38347853/bibliometric-analysis-of-research-on-traditional-chinese-exercise-and-osteoarthritis
#37
JOURNAL ARTICLE
Qiu Zeng, Xiaoyi Liu, Lina Li, Qin Zhang, Chengping Luo, Shu Yang, Shuqiang Wu, An Yang, Jie Li
BACKGROUND: Osteoarthritis (OA) is a common disease in geriatric rehabilitation medicine caused by the progressive destruction of articular cartilage. Traditional Chinese exercise (TCE) is an important component of traditional sports in China and aims to stretch the musculoskeletal tract and relieve joint pain. Bibliometrics can help researchers find suitable partners and understand the research hotspots and trends in a certain field. However, there is still a lack of bibliometric analysis in the field of TCE and OA...
2024: Journal of Pain Research
https://read.qxmd.com/read/38347747/a-matching-adjusted-indirect-comparison-of-the-efficacy-of-elranatamab-versus-teclistamab-in-patients-with-triple-class-exposed-refractory-multiple-myeloma
#38
JOURNAL ARTICLE
Isha Mol, Yannan Hu, Thomas W LeBlanc, Joseph C Cappelleri, Haitao Chu, Guido Nador, Didem Aydin, Alex Schepart, Patrick Hlavacek
For patients with triple-class exposed/refractory multiple myeloma (TCE/RMM), where effective treatments options are limited, B-cell maturation antigen and CD3-directed bispecific antibodies offer a promising new approach. Teclistamab gained conditional approval in Europe and accelerated Food and Drug Administration (FDA) approval based on the MajesTEC-1 trial (NCT03145181). Elranatamab, approved by the FDA demonstrated its safety and efficacy in the MagnetisMM-3 trial (NCT04649359). Given the absence of head-to-head trials, an unanchored matching-adjusted indirect comparison (MAIC) was conducted to assess their relative efficacy...
February 12, 2024: Leukemia & Lymphoma
https://read.qxmd.com/read/38342459/an-innovative-permeable-reactive-bio-barrier-to-remediate-trichloroethene-contaminated-groundwater-a-field-study
#39
JOURNAL ARTICLE
Che-Wei Lu, Kai-Hung Lo, Sun-Chong Wang, Chih-Ming Kao, Ssu-Ching Chen
Permeable reactive bio-barrier (PRBB), an innovative technology, could treat many contaminants via the natural gradient flow of groundwater based on immobilization or transformation of pollutants into less toxic and harmful forms. In this field study, we developed an innovative PRBB system comprising immobilized Dehalococcoides mccartyi (Dhc) and Clostridium butyricum embedded into the silica gel for long-term treatment of trichloroethene (TCE) polluted groundwater. Four injection wells and two monitoring wells were installed at the downstream of the TCE plume...
February 9, 2024: Science of the Total Environment
https://read.qxmd.com/read/38316390/response-of-tce-biodegradation-to-elevated-h-2-and-o-2-implication-for-electrokinetic-enhanced-bioremediation
#40
JOURNAL ARTICLE
Weiwei Ouyang, Yao Huang, Cui Li, Chen Xue, Minghui Liu, Jie Ma, Songhu Yuan, Hui Liu
The study investigated the influences of pure H2 and O2 introduction, simulating gases produced from the electrokinetic-enhanced bioremediation (EK-Bio), on TCE degradation, and the dynamic changes of the indigenous microbial communities. The dissolved hydrogen (DH) and oxygen (DO) concentrations ranged from 0.2 to 0.7 mg/L and 2.6-6.6 mg/L, respectively. The biological analysis was conducted by 16S rRNA sequencing and functional gene analyses. The results showed that the H2 introduction enhanced TCE degradation, causing a 90...
February 3, 2024: Environmental Research
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