Laura Díez-Alonso, Aïda Falgas, Javier Arroyo-Ródenas, Paola A Romencín, Alba Martínez, Marina Gómez-Rosel, Belén Blanco, Anaïs Jiménez-Reinoso, Andrea Mayado, Alba Pérez-Pons, Óscar Aguilar-Sopeña, Ángel Ramírez-Fernández, Alejandro Segura-Tudela, Lorena Perez-Amill, Antonio Tapia-Galisteo, Carmen Domínguez-Alonso, Laura Rubio-Pérez, Maria Jara, Francesc Solé, Oana Hangiu, Laura Almagro, Ángela Albitre, Petronila Penela, Laura Sanz, Eduardo Anguita, Antonio Valeri, Almudena García-Ortiz, Paula Río, Manel Juan, Joaquín Martínez-López, Pedro Roda-Navarro, Beatriz Martín-Antonio, Alberto Orfao, Pablo Menéndez, Clara Bueno, Luis Álvarez-Vallina
Multiple myeloma is the second most common hematological malignancy in adults and remains an incurable disease. B cell maturation antigen (BCMA)-directed immunotherapy, including T cells bearing chimeric antigen receptors (CARs) and systemically injected bispecific T cell engagers (TCEs), has shown remarkable clinical activity, and several products have received market approval. However, despite promising results, most patients eventually become refractory and relapse, highlighting the need for alternative strategies...
February 14, 2024: Science Translational Medicine