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https://www.readbyqxmd.com/read/29327399/plga-mpeg-nanoparticles-loaded-with-melatonin-protect-adipose-derived-stem-cells-transplanted-in-infarcted-heart-tissue
#1
Qiang Ma, Junjie Yang, Xu Huang, Weisheng Guo, Sulei Li, Hao Zhou, Jingwei Li, Yundai Chen
Stem cell transplantation is a promising therapeutic strategy for myocardial infarction. However, transplanted cells face low survival rates due to oxidative stress and the inflammatory microenvironment in ischemic heart tissue. Melatonin has been used as a powerful endogenous antioxidant to protect cells from oxidative injury. However, melatonin cannot play a long lasting effect against the hostile microenvironment. Nano drug delivery carriers have the ability to protect the loaded drug from degradation in physiological environments in a controlled manner, which results in longer effects and decreased side effects...
January 12, 2018: Stem Cells
https://www.readbyqxmd.com/read/29326493/renal-mitochondria-can-withstand-hypoxic-ischemic-injury-secondary-to-renal-failure-in-uremic-rats-pretreated-with-sodium-thiosulfate
#2
Dhivya Mohan, Eswari Dhivya Balasubramanian, Sriram Ravindran, Gino A Kurian
BACKGROUND: Sodium thiosulfate (STS) is a potent drug used to treat calcific uremic arteriopathy in dialysis patients and its mode of action is envisaged by calcium chelation and antioxidant potential. STS's action on mitochondrial dysfunction, one of the major players in the pathology of vascular calcification is yet to be explored. METHODS: Adenine (0.75%, 28 days)-treated vascular calcified rat kidney was used to isolate mitochondria, where the animal was administered with or without STS for 28 days...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29303551/engineering-bioinspired-antioxidant-materials-promoting-cardiomyocyte-functionality-and-maturation-for-tissue-engineering-application
#3
Parvaiz Ahmad Shiekh, Anamika Singh, Ashok Kumar
Oxidative stress plays an important role in various pathological conditions such as wound healing, inflammation, myocardial infarction and biocompatibility of the materials. Antioxidant polymers to attenuate oxidative stress is an emerging field of biomaterial research with a huge impact in the field of tissue engineering and regenerative medicine. We describe here the fabrication and evaluation of an elastomeric antioxidant polyurethane (PUAO) for tissue engineering applications. Uniaxial and cyclic tensile testing, thermal analysis, degradation, cytotoxicity and antioxidant analysis was carried out...
January 5, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29278365/sexually-dimorphic-outcomes-after-neonatal-stroke-and-hypoxia-ischemia
#4
REVIEW
Christiane Charriaut-Marlangue, Valérie C Besson, Olivier Baud
Cohort studies have demonstrated a higher vulnerability in males towards ischemic and/or hypoxic-ischemic injury in infants born near- or full-term. Male sex was also associated with limited brain repair following neonatal stroke and hypoxia-ischemia, leading to increased incidence of long-term cognitive deficits compared to females with similar brain injury. As a result, the design of pre-clinical experiments considering sex as an important variable was supported and investigated because neuroprotective strategies to reduce brain injury demonstrated sexual dimorphism...
December 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29207167/prazosin-protects-myocardial-cells-against-anoxia-reoxygenation-injury-via-the-extracellular-signal%C3%A2-regulated-kinase-signaling-pathway
#5
Lixin Wang, Yan Xue, Hao Ma, Haiyan Shi, Ling Wang, Xiaozheng Cui
Ischemic heart disease (including coronary arterial atherosclerosis, or vascular cavity stenosis or occlusion) remains the leading cause of disease‑associated mortality worldwide. Prazosin, a receptor blocker of postsynaptic adrenaline, is essential in expanding peripheral arteries, which decreases peripheral vascular resistance, and regulates anti‑hypertensive action. However, the mechanisms underlying the effects of prazosin have not been fully elucidated. The aim of the present study was to investigate the protective effects of prazosin on myocardial cells against anoxia‑reoxygenation injury in a mouse model...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29194835/oxidative-stress-diseases-unique-to-the-perinatal-period-a-window-into-the-developing-innate-immune-response
#6
Robert M Dietz, Clyde J Wright
The innate immune system has evolved to play an integral role in the normally developing lung and brain. However, in response to oxidative stress, innate immunity, mediated by specific cellular and molecular programs and signaling, contributes to pathology in these same organ systems. Despite opposing drivers of oxidative stress, namely hyperoxia in neonatal lung injury and hypoxia/ischemia in neonatal brain injury, similar pathways-including toll-like receptors, NFκB and MAPK cascades-have been implicated in tissue damage...
November 30, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29187364/characterization-of-cd38-in-the-major-cell-types-of-the-heart-endothelial-cells-highly-express-cd38-with-activation-by-hypoxia-reoxygenation-depleting-nad-p-h
#7
James Boslett, Craig Hemann, Fivos L Christofi, Jay L Zweier
The NAD(P)+-hydrolyzing enzyme CD38 is activated in the heart during the process of ischemia and reperfusion, triggering NAD(P)(H) depletion. However, the presence and role of CD38 in the major cell types of the heart are unknown. Therefore, we characterize the presence and function of CD38 in cardiac myocytes, endothelial cells, and fibroblasts. To comprehensively evaluate CD38 in these cells, we measured gene transcription via mRNA, as well as protein expression and enzymatic activity. Endothelial cells strongly expressed CD38, while only low expression was present in cardiac myocytes with intermediate levels in fibroblasts...
November 29, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29137683/tanshinone-i-alleviates-motor-and-cognitive-impairments-via-suppressing-oxidative-stress-in-the-neonatal-rats-after-hypoxic-ischemic-brain-damage
#8
Chunfang Dai, Yannan Liu, Zhifang Dong
Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown that tanshinone I (TsI), one of the major ingredients of Danshen, exerts potential neuroprotective effect in adult mice exposed to permanent left cerebral ischemia. However, it is unclear whether administration of TsI has neuroprotective effect on neonatal hypoxic-ischemic brain damage (HIBD), and if so, the potential mechanisms also remain unclear. Here, we reported that treatment with TsI (5 mg/kg, i...
November 14, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29130334/pulsed-epr-imaging-applications-in-the-studies-of-tumor-physiology
#9
Shun Kishimoto, Ken-Ichiro Matsumoto, Keita Saito, Ayano Enomoto, Shingo Matsumoto, James Mitchell, Nallathamby Devasahayam, Murali C Krishna
SIGNIFICANCE: Electron Paramagnetic Resonance imaging (EPRI) is a powerful technique capable of generating images of tissue oxygenation using exogenous paramagnetic probes such as trityl radicals or nitroxyl radicals. Using principles similar to Magnetic Resonance Imaging (MRI) with field gradients, the spatial distribution of the paramagnetic probecan be generatedand,from its spectral features, spatial maps of oxygen can be obtained from live objects. In this review, two methods of signal acquisition, image formation/reconstruction will be described...
November 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29107469/diseases-of-the-retina-and-the-optic-nerve-associated-with-obstructive-sleep-apnea
#10
REVIEW
Marielle Mentek, Florent Aptel, Diane Godin-Ribuot, Renaud Tamisier, Jean-Louis Pepin, Christophe Chiquet
Many associations between ocular disorders and obstructive sleep apnea (OSA) have been studied, such as nonarteritic anterior ischemic optic neuropathy, glaucoma, papilledema, retinal vein occlusion, eyelid hyperlaxity, lower-eyelid ectropion and recurrent corneal erosions. The objective of this review is to synthetize the possible vascular disorders of the retina and the optic nerve associated with sleep apnea patients and to discuss the underlying pathophysiological hypotheses. Main mechanisms involved in the ocular complications of OSA are related to intermittent hypoxia, sympathetic system activation, oxidant stress, and deleterious effects of endothelin 1...
May 29, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29101173/ph-recovery-from-a-proton-load-in-rat-cardiomyocytes-effects-of-chronic-exercise
#11
Vennetia R Danes, Josephine Anthony, Kaveh Rayani, Kenneth W Spitzer, Glen F Tibbits
The ability of cardiomyocytes to recover from a proton load was examined in the hearts of exercise-trained (T) and sedentary control (C) rats in CO2/HCO3--free media. Acidosis was created by the NH4Cl pre-pulse technique and pHi was determined using fluorescence microscopy on carboxy-SNARF-1 AM loaded isolated cardiomyocytes. CO2-independent intracellular pH buffering capacity (βi) was measured by incrementally reducing the [NH4Cl]o in steps of 50% from 20 to 1.25 mM. βi increased as pHi decreased in both T and C groups...
November 3, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29039446/protective-effect-of-autophagy-in-neural-ischemia-and-hypoxia-negative-regulation-of-the-wnt-%C3%AE-catenin-pathway
#12
Zhen-Yu Shi, Jie-Xin Deng, Su Fu, Lai Wang, Qiang Wang, Bin Liu, Yong-Qiang Li, Jin-Bo Deng
Autophagy is a highly conserved process of self-digestion to promote cell survival in response to nutrient starvation and other metabolic stresses. However, whether ischemic-hypoxic (IH) injury-induced autophagy acts as a neuroprotective mechanism or leads to neuroinjury is a subject of debate. It is known that autophagy is regulated by signaling pathways, including the mammalian target of rapamycin pathway. However, in neural IH injury, whether other signaling pathways are involved in the regulation of autophagy remains to be fully elucidated...
September 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29018332/the-beneficial-effects-of-melatonin-administration-following-hypoxia-ischemia-in-preterm-fetal-sheep
#13
Tamara Yawno, Mawin Mahen, Jingang Li, Michael C Fahey, Graham Jenkin, Suzanne L Miller
Melatonin (MLT) is an endogenous hormone that controls circadian cycle. MLT has additional important properties that make it appealing as a neuroprotective agent-it is a potent anti-oxidant, with anti-apoptotic and anti-inflammatory properties. MLT is safe for administration during pregnancy or to the newborn after birth, and can reduce white matter brain injury under conditions of chronic fetal hypoxia. Accordingly, in the current study, we examined whether an intermediate dose of MLT could restore white matter brain development when administered after an acute hypoxic ischemic (HI) insult in preterm fetal sheep...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28975464/peroxynitrite-induced-tyrosine-nitration-contributes-to-matrix-metalloprotease-3-activation-relevance-to-hyperglycemic-ischemic-brain-injury-and-tissue-plasminogen-activator
#14
Sherif Hafez, Mohammed Abdelsaid, Susan C Fagan, Adviye Ergul
Matrix metalloprotease-3 (MMP3) activation mediates the tissue plasminogen activator (tPA)-induced hemorrhagic transformation after stroke. Hyperglycemia (HG) further exacerbates this outcome. We have recently shown that HG increases MMP3 activity in the brain after stroke. However, the combined HG-tPA effect on MMP3 activation, and the mechanisms through which MMP3 is activated were not previously reported. Accordingly, this study tested the hypothesis that tPA and HG increases MMP3 activity in the brain after stroke through peroxynitrite induced tyrosine nitration...
October 3, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28883688/a-controversial-medicolegal-issue-timing-the-onset-of-perinatal-hypoxic-ischemic-brain-injury
#15
REVIEW
Vittorio Fineschi, Rocco Valerio Viola, Raffaele La Russa, Alessandro Santurro, Paola Frati
Perinatal hypoxic-ischemic brain injury, as a result of chronic, subacute, and acute insults, represents the pathological consequence of fetal distress and birth or perinatal asphyxia, that is, "nonreassuring fetal status." Hypoxic-ischemic injury (HII) is typically characterized by an early phase of damage, followed by a delayed inflammatory local response, in an apoptosis-necrosis continuum. In the early phase, the cytotoxic edema and eventual acute lysis take place; with reperfusion, additional damage should be assigned to excitotoxicity and oxidative stress...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28876386/a-possible-relationship-between-gluconeogenesis-and-glycogen-metabolism-in-rabbits-during-myocardial-ischemia
#16
Raquel R DE Aguiar, Daniela F Vale, Renato M DA Silva, Yolanda P Muniz, Fernanda Antunes, Carlos Logullo, André L A Oliveira, Adriana J DE Almeida
Ischemia is responsible for many metabolic abnormalities in the heart, causing changes in organ function. One of modifications occurring in the ischemic cell is changing from aerobic to anaerobic metabolism. This change causes the predominance of the use of carbohydrates as an energy substrate instead of lipids. In this case, the glycogen is essential to the maintenance of heart energy intake, being an important reserve to resist the stress caused by hypoxia, using glycolysis and lactic acid fermentation. In order to study the glucose anaerobic pathways utilization and understand the metabolic adaptations, New Zealand white rabbits were subjected to ischemia caused by Inflow occlusion technique...
July 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28865712/microrna-31-promotes-adverse-cardiac-remodeling-and-dysfunction-in-ischemic-heart-disease
#17
Eliana C Martinez, Shera Lilyanna, Peipei Wang, Leah A Vardy, Xiaofei Jiang, Arunmozhiarasi Armugam, Kandiah Jeyaseelan, Arthur Mark Richards
RATIONALE: Myocardial infarction (MI) triggers a dynamic microRNA response with the potential of yielding therapeutic targets. OBJECTIVE: We aimed to identify novel aberrantly expressed cardiac microRNAs post-MI with potential roles in adverse remodeling in a rat model, and to provide post-ischemic therapeutic inhibition of a candidate pathological microRNA in vivo. METHODS AND RESULTS: Following microRNA array profiling in rat hearts 2 and 14days post-MI, we identified a time-dependent up-regulation of miR-31 compared to sham-operated rats...
November 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28852062/farnesoid-x-receptor-activation-protects-the-kidney-from-ischemia-reperfusion-damage
#18
Zhibo Gai, Lei Chu, Zhenqiang Xu, Xiaoming Song, Dongfeng Sun, Gerd A Kullak-Ublick
Farnesoid X receptor (FXR) activation has been reported to reduce inflammation and oxidative stress. Because both inflammation and oxidative stress are critical for tissue destruction during kidney ischemia reperfusion (I/R) injury, we investigated the protective role of FXR against kidney damage induced by I/R in mice. Mice undergoing renal I/R developed the typical features of acute kidney injury (AKI): increased creatinine, albuminuria, tubular necrosis and apoptosis. Inflammatory cytokine production and oxidative stress were also markedly increased...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28851980/hypoxic-stress-decreases-c-myc-protein-stability-in-cardiac-progenitor-cells-inducing-quiescence-and-compromising-their-proliferative-and-vasculogenic-potential
#19
Michael A Bellio, Mariana T Pinto, Victoria Florea, Paola A Barrios, Christy N Taylor, Ariel B Brown, Courtney Lamondin, Joshua M Hare, Ivonne H Schulman, Claudia O Rodrigues
Cardiac progenitor cells (CPCs) have been shown to promote cardiac regeneration and improve heart function. However, evidence suggests that their regenerative capacity may be limited in conditions of severe hypoxia. Elucidating the mechanisms involved in CPC protection against hypoxic stress is essential to maximize their cardioprotective and therapeutic potential. We investigated the effects of hypoxic stress on CPCs and found significant reduction in proliferation and impairment of vasculogenesis, which were associated with induction of quiescence, as indicated by accumulation of cells in the G0-phase of the cell cycle and growth recovery when cells were returned to normoxia...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28838842/ellagic-acid-antagonizes-bnip3-mediated-mitochondrial-injury-and-necrotic-cell-death-of-cardiac-myocytes
#20
Abhinav Dhingra, Rahul Jayas, Pegah Afshar, Matthew Guberman, Graham Maddaford, Johnathan Gerstein, Brooke Lieberman, Hilary Nepon, Victoria Margulets, Rimpy Dhingra, Lorrie A Kirshenbaum
The Bcl-2 protein Bnip3 is crucial for provoking oxidative injury to mitochondria following anthracycline treatment or ischemia-reperfusion injury. Herein, we investigate the effects of the polyphenolic compound ellagic acid (EA) on Bnip3 mediated mitochondrial injury and necrotic cell death in cardiac myocytes. In contrast to vehicle treated cardiomyocytes, Bnip3 was highly enriched in mitochondrial fractions of cardiac myocytes treated with the anthracycline doxorubicin or in cells subjected to hypoxia (HPX)...
August 25, 2017: Free Radical Biology & Medicine
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