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https://www.readbyqxmd.com/read/29897293/the-oxytocin-receptor-from-intracellular-signaling-to-behavior
#1
Benjamin Jurek, Inga D Neumann
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly 25,000 publications since 1930 (see FIGURE 1 , as listed in PubMed), which revealed central roles for OXT and its receptor (OXTR) in reproduction, and social and emotional behaviors in animal and human studies focusing on mental and physical health and disease. In this review, we discuss the mechanisms of OXT expression and release, expression and binding of the OXTR in brain and periphery, OXTR-coupled signaling cascades, and their involvement in behavioral outcomes to assemble a comprehensive picture of the central and peripheral OXT system...
July 1, 2018: Physiological Reviews
https://www.readbyqxmd.com/read/29878148/biomarkers-of-nutrition-for-development-bond-iron-review
#2
Sean Lynch, Christine M Pfeiffer, Michael K Georgieff, Gary Brittenham, Susan Fairweather-Tait, Richard F Hurrell, Harry J McArdle, Daniel J Raiten
This is the fifth in the series of reviews developed as part of the Biomarkers of Nutrition for Development (BOND) program. The BOND Iron Expert Panel (I-EP) reviewed the extant knowledge regarding iron biology, public health implications, and the relative usefulness of currently available biomarkers of iron status from deficiency to overload. Approaches to assessing intake, including bioavailability, are also covered. The report also covers technical and laboratory considerations for the use of available biomarkers of iron status, and concludes with a description of research priorities along with a brief discussion of new biomarkers with potential for use across the spectrum of activities related to the study of iron in human health...
June 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29872924/a-mindfulness-intervention-to-reduce-maternal-distress-in-neonatal-intensive-care-a-mixed-methods-pilot-study
#3
Tamar Mendelson, Ciara McAfee, April Joy Damian, Amitoj Brar, Pamela Donohue, Erica Sibinga
Mothers with an infant in the neonatal intensive care unit (NICU) are at risk for depression, anxiety, and trauma symptoms, with negative implications for maternal-infant bonding, maternal well-being, and infant development. Few interventions to promote NICU mothers' mental health, however, have been developed or tested. This pre-post pilot study assessed feasibility, acceptability, and preliminary outcomes of a mindfulness intervention for NICU mothers. Twenty-seven mothers were recruited from a university NICU and offered a mindfulness intervention via introductory video and audio-recorded practices...
June 5, 2018: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29861884/a-handy-preterm-infant-incubator-for-providing-intensive-care-simulation-3d-printed-prototype-and-evaluation
#4
Amira J Zaylaa, Mohamad Rashid, Mounir Shaib, Imad El Majzoub
Preterm infants encounter an abrupt delivery before their complete maturity during the third trimester of pregnancy. Polls anticipate an increase in the rates of preterm infants for 2025, especially in middle- and low-income countries. Despite the abundance of intensive care methods for preterm infants, such as, but not limited to, commercial, transport, embrace warmer, radiant warmer, and Kangaroo Mother Care methods, they are either expensive, lack the most essential requirements or specifications, or lack the maternal-preterm bond...
2018: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29807652/selective-and-non-selective-ot-receptor-agonists-induce-different-locomotor-behaviors-in-male-rats-via-central-ot-receptors-and-peripheral-v1a-receptors
#5
Monica Wolfe, Halina Wisniewska, Hiroe Tariga, Gerardo Ibanez, James C Collins, Kazimierz Wisniewski, Steve Qi, Karthik Srinivasan, Diane Hargrove, Beatriz Fioravanti Lindstrom
Oxytocin (OT) continues to inspire much research due to its diverse physiological effects. While the best-understood actions of OT are uterine contraction and milk ejection, OT is also implicated in maternal and bonding behaviors, and potentially in CNS disorders such as autism, schizophrenia, and pain. The dissection of the mechanism of action of OT is complicated by the fact that this peptide activates not only its cognate receptor but also vasopressin type 1a (V1a) receptors. In this study, we evaluated OT and a selective OT receptor (OTR) agonist, FE 204409, in an automated assay that measures rat locomotor activity...
May 21, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29767917/puerperae-bonding-with-their-children-and-labor-experiences
#6
Lara Helk Souza, Zaida Aurora Sperli Geraldes Soler, Maria de Lourdes Sperli Geraldes Santos, Natália Sperli Geraldes Marin Dos Santos Sasaki
OBJECTIVES: To analyze the degree of bonding of puerperae with their babies, both in isolation and associated with experiences during and after labor. METHODS: A cross-sectional study carried out among 200 puerperae in São José do Rio Preto, Brazil. To evaluate the mother-child bond, we used the Mother-to-Infant Bonding Scale (MIBS). RESULTS: The mean age of puerperae was 26.4 years; most women were white (60.0%), were married (87.5%), and had an elementary education (51...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29753459/infant-handling-in-bonobos-pan-paniscus-exploring-functional-hypotheses-and-the-relationship-to-oxytocin
#7
Klaree Boose, Frances White, Colin Brand, Audra Meinelt, Josh Snodgrass
Infant handling describes interactions between infants and non-maternal group members and is widespread across mammalian taxa. The expression of infant handling behaviors, defined as any affiliative or agonistic interaction between a group member and an infant, varies considerably among primate species. Several functional hypotheses may explain the adaptive value of infant handling including the Kin Selection hypothesis, which describes handling as a mechanism through which indirect fitness is increased and predicts a bias in handling behaviors directed toward related (genetic) infants; the Alliance Formation hypothesis, which describes handling as a social commodity and predicts females with infants will support handlers during conflict; and the Learning-to-Mother hypothesis, which describes handling as a mechanism through which handlers learn species-specific maternal behaviors and predicts that handling will occur most frequently in immature and nulliparous females...
May 9, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29740335/amniotic-fluid-insl3-measured-during-the-critical-time-window-in-human-pregnancy-relates-to-cryptorchidism-hypospadias-and-phthalate-load-a-large-case-control-study
#8
Ravinder Anand-Ivell, Arieh Cohen, Bent Nørgaard-Pedersen, Bo A G Jönsson, Jens-Peter Bonde, David M Hougaard, Christian H Lindh, Gunnar Toft, Morten S Lindhard, Richard Ivell
The period of the first to second trimester transition in human pregnancy represents a sensitive window for fetal organogenesis, particularly in regard to the development of the male reproductive system. This is a time of relative analytical inaccessibility. We have used a large national biobank of amniotic fluid samples collected at routine amniocentesis to determine the impacts of exogenous endocrine disruptor load on specific fetal biomarkers at this critical time. While adrenal and testicular steroids are highly correlated, they are also mostly positively influenced by increasing phthalate load, represented by the metabolites 7cx-MMeHP and 5cx-MEPP, by perfluorooctane sulfonate (PFOS) exposure, and by smoking, suggesting an adrenal stress response...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29733398/pre-pregnancy-fast-food-and-fruit-intake-is-associated-with-time-to-pregnancy
#9
Jessica A Grieger, Luke E Grzeskowiak, Tina Bianco-Miotto, Tanja Jankovic-Karasoulos, Lisa J Moran, Rebecca L Wilson, Shalem Y Leemaqz, Lucilla Poston, Lesley McCowan, Louise C Kenny, Jenny Myers, James J Walker, Robert J Norman, Gus A Dekker, Claire T Roberts
STUDY QUESTION: Is preconception dietary intake associated with reduced fecundity as measured by a longer time to pregnancy (TTP)? SUMMARY ANSWER: Lower intake of fruit and higher intake of fast food in the preconception period were both associated with a longer TTP. WHAT IS KNOWN ALREADY: Several lifestyle factors, such as smoking and obesity, have consistently been associated with a longer TTP or infertility, but the role of preconception diet in women remains poorly studied...
May 4, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29716811/neuropeptide-oxytocin-enhances-%C3%AE-opioid-receptor-signaling-as-a-positive-allosteric-modulator
#10
Yoshiyuki Meguro, Kanako Miyano, Shigeto Hirayama, Yuki Yoshida, Naoto Ishibashi, Takumi Ogino, Yuriko Fujii, Sei Manabe, Moeko Eto, Miki Nonaka, Hideaki Fujii, Yoichi Ueta, Minoru Narita, Naohiro Sata, Toshihiko Yada, Yasuhito Uezono
Oxytocin (OT) is a 9-amine neuropeptide that plays an essential role in mammalian labor, lactation, maternal bonding, and social affiliation. OT has been reported to exert an analgesic effect in both humans and animals, and the results of certain animal experiments have shown that the analgesic effect of OT is partially blocked by opioid receptor antagonists. To investigate the relationship between OT and μ opioid receptor (MOR), we evaluated how OT affects MOR in vitro by performing an electrical impedance-based receptor biosensor assay (CellKey™ assay), an intracellular cAMP assay, and a competitive receptor-binding analysis by using cells stably expressing human MOR and OT receptor...
April 11, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29705572/maternal-oxytocin-predicts-relationship-survival-during-the-perinatal-transition-period-preliminary-evidence
#11
Cecile Sunahara, P Zelkowitz, Niall Bolger, Gentiana Sadikaj, Simcha Samuel, Ian Gold, Barbara Hayton, Nancy Feeley, C Sue Carter, Jennifer A Bartz
It is well-known that the neuropeptide oxytocin plays a critical role regulating the formation of adult-adult pairbonds in non-human animals, and recent work suggests oxytocin may similarly play an important role in romantic bonding in humans. Specifically, endogenous oxytocin is predictive of a host of relationship-enhancing behaviors, relationship quality, and even relationship survival amongst newly dating couples. This work suggests that oxytocin can buffer romantic relationships, possibly during especially difficult transition periods...
April 26, 2018: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29705428/adsa-foundation-scholar-award-a-role-for-serotonin-in-lactation-physiology-where-do-we-go-from-here
#12
L L Hernandez
Lactation is a physiological event that is exclusive to mammals. Lactation evolved as a strategy to improve the survival of the young by providing them with the complete nutrition that is required for survival upon birth as well as maternal-offspring bonding. Typically, milk production by the dam matches the demand of the young. The dairy cow is a unique exception in which the discoveries and genetic selection related to lactation physiology have been applied and resulted in a dramatic increase in milk yield of dairy cows...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29673720/-study-of-parental-bonding-in-childhood-in-children-and-adolescents-with-anorexia-nervosa
#13
A M H Albinhac, F A M Jean, M P Bouvard
INTRODUCTION: Anorexia nervosa constitutes a severe and complex eating disorder occurring principally in adolescence. It is one of the most deadly psychiatric disorders. Considering the multifactorial nature of anorexia nervosa, the important place of the family and the growing interest in the theory of attachment in eating disorders, parental bonding is questioned in anorexia nervosa. The main study goal is to analyze parental bonding in a population of children and adolescents with anorexia nervosa...
April 16, 2018: L'Encéphale
https://www.readbyqxmd.com/read/29662695/impact-of-a-health-system-strengthening-intervention-on-maternal-and-child-health-outputs-and-outcomes-in-rural-rwanda-2005-2010
#14
Dana R Thomson, Cheryl Amoroso, Sidney Atwood, Matthew H Bonds, Felix Cyamatare Rwabukwisi, Peter Drobac, Karen E Finnegan, Didi Bertrand Farmer, Paul E Farmer, Antoinette Habinshuti, Lisa R Hirschhorn, Anatole Manzi, Peter Niyigena, Michael L Rich, Sara Stulac, Megan B Murray, Agnes Binagwaho
Introduction: Although Rwanda's health system underwent major reforms and improvements after the 1994 Genocide, the health system and population health in the southeast lagged behind other areas. In 2005, Partners In Health and the Rwandan Ministry of Health began a health system strengthening intervention in this region. We evaluate potential impacts of the intervention on maternal and child health indicators. Methods: Combining results from the 2005 and 2010 Demographic and Health Surveys with those from a supplemental 2010 survey, we compared changes in health system output indicators and population health outcomes between 2005 and 2010 as reported by women living in the intervention area with those reported by the pooled population of women from all other rural areas of the country, controlling for potential confounding by economic and demographic variables...
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29651928/rural-postpartum-women-with-substance-use-disorders
#15
Debra Kramlich, Rebecca Kronk, Lenora Marcellus, Alison Colbert, Karen Jakub
The incidence of perinatal opioid use and neonatal withdrawal continues to rise rapidly in the face of the growing opioid addiction epidemic in the United States, with rural areas more severely affected. Despite decades of research and development of practice guidelines, maternal and neonatal outcomes have not improved substantially. This focused ethnography sought to understand the experience of accessing care necessary for substance use disorder recovery, pregnancy, and parenting. Personal accounts of 13 rural women, supplemented by participant observation and media artifacts, uncovered three domains with underlying themes: challenges of getting treatment and care (service availability, distance/geographic location, transportation, provider collaboration/coordination, physical and emotional safety), opportunities to bond (proximity, information), and importance of relationships (respect, empathy, familiarity, inclusion, interactions with care providers)...
April 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29650187/the-influence-of-adolescent-postpartum-women-s-psychosocial-condition-on-mother-infant-bonding
#16
Ariani Fatmawati, Imami Nur Rachmawati, Tri Budiati
OBJECTIVE: To identify the correlation between the psychosocial condition of adolescent women in the postpartum period and mother-infant bonding. METHOD: This study used a cross-sectional design. Using a consecutive sampling method, 103 adolescent women with a 1- to 12-week-old baby were recruited. Participants completed the postpartum bonding questionnaire to identify mother-infant bonding. This questionnaire included four dimensions: the relationship between mother and baby, baby acceptance, readiness to perform maintenance, and delivery of comfort...
February 2018: Enfermería Clínica
https://www.readbyqxmd.com/read/29642681/the-effect-of-nutrition-and-body-condition-of-triplet-bearing-ewes-during-late-pregnancy-on-the-behaviour-of-ewes-and-lambs
#17
Gabriella V Gronqvist, Rene A Corner-Thomas, Paul R Kenyon, Kevin J Stafford, Stephen T Morris, Rebecca Edith Hickson
Objective: Triplet-born lambs are less likely to survive to weaning than twin-born or single-born lambs. Appropriate ewe-lamb bonding behaviours and lamb vigour behaviours are necessary for survival of lambs. The aim of this experiment was to determine whether maternal nutrition during late pregnancy influenced behaviour of the ewe and her lambs soon after birth, and to determine whether mid-pregnancy body condition score (BCS) influenced any behavioural response. Methods: The experiments included ewes that were in BCS 2...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/29595379/child-malnutrition-in-ifanadiana-district-madagascar-associated-factors-and-timing-of-growth-faltering-ahead-of-a-health-system-strengthening-intervention
#18
Sarah McCuskee, Andres Garchitorena, Ann C Miller, Lara Hall, Mohammed Ali Ouenzar, Victor R Rabeza, Ranto H Ramananjato, Hery-Tiana Rahaniraka Razanadrakato, Marius Randriamanambintsoa, Michele Barry, Matthew H Bonds
BACKGROUND: Child malnutrition, a leading cause of death and disability worldwide, is particularly severe in Madagascar, where 47% of children under 5 years are stunted (low height-for-age) and 8% are wasted (low weight-for-height). Widespread poverty and a weak health system have hindered attempts to implement life-saving malnutrition interventions in Madagascar during critical periods for growth faltering. OBJECTIVE: This study aimed to shed light on the most important factors associated with child malnutrition, both acute and chronic, and the timing of growth faltering, in Ifanadiana, a rural district of Madagascar...
2018: Global Health Action
https://www.readbyqxmd.com/read/29576212/-mother-baby-follow-up-at-home-and-the-welcome-of-the-baby-in-the-family
#19
Florence Petit-Lacroix, Christine Garcia-Valadier
Upon discharge from the maternity hospital, the newborn is welcomed not only in a home but also within a family. The postnatal follow-up over the first few weeks can take several forms: a programme to support the return home, hospital at home service or follow-up by a private practice midwife or professionals from the mother and infant welfare protection service. The aim is to meet the needs of the baby, favour the establishment of the parent-baby bond and to support the construction of parenthood.
March 2018: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/29540338/evaluation-of-technology-based-peer-support-intervention-program-for-preventing-postnatal-depression-protocol-for-a-randomized-controlled-trial
#20
Shefaly Shorey, Cornelia Chee, Yap-Seng Chong, Esperanza Debby Ng, Ying Lau, Cindy-Lee Dennis
BACKGROUND: Multiple international agencies, including the World Health Organization and the International Monetary Fund, have emphasized the importance of maternal mental health for optimal child health and development. Adequate social support is vital for the most vulnerable to postpartum mood disorders. Hence, an urgent need for sustainable social support programs to aid mothers ease into their new parenting role exists. OBJECTIVE: This study protocol aims to examine the effectiveness of a technology-based peer support intervention program among mothers at risk for postnatal depression in the early postpartum period...
March 14, 2018: JMIR Research Protocols
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