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JOURNAL ARTICLE
Yuan Zhang, Jianfeng Xu, Pengcheng Li, Bo Luo, Hui Tang
Elevated transport of Caveolin-1 (CAV-1) vesicles within vascular endothelial cells constitutes a significant secondary pathogenic event contributing to the compromise of the blood-brain barrier (BBB) post-traumatic brain injury (TBI). While Wnt/β-catenin signaling is recognized for its critical involvement in angiogenesis and the maintenance of BBB integrity, its influence on vascular endothelial transcytosis in the aftermath of TBI is not well-defined. This study aims to elucidate the impact of Wnt/β-catenin signaling on cerebrovascular vesicular transcytosis following TBI...
April 17, 2024: Experimental Neurology
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JOURNAL ARTICLE
Farshad Abedi, Batool Zarei, Sepideh Elyasi
PURPOSE: Nowadays, it is largely accepted that albumin should not be used in hypoalbuminemia or for nutritional purpose. The most discussed indication of albumin at present is the resuscitation in shock states, especially distributive shocks such as septic shock. The main evidence-based indication is also liver disease. In this review, we provided updated evidence-based instruction for definite and potential indications of albumin administration in clinical practice, with appropriate dosing and duration...
April 12, 2024: European Journal of Clinical Pharmacology
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JOURNAL ARTICLE
Antonio Coppola, Gianna Franca Rivolta, Gabriele Quintavalle, Annalisa Matichecchia, Federica Riccardi, Rossana Rossi, Anna Benegiamo, Paola Ranalli, Valeria Coluccio, Annarita Tagliaferri
Background : Extended half-life (EHL) factor IX (FIX) concentrates allow for prophylaxis with prolonged dosing intervals and high bleeding protection in persons with hemophilia B. Long-term real-world studies are lacking. Methods : In a retrospective-prospective study, the six-year use of prophylaxis with the EHL recombinant FIX-albumin fusion protein (rIX-FP) was analyzed, comparing outcomes with previous standard half-life (SHL) FIX in patients already on prophylaxis. Results : Prophylaxis with rIX-FP was prescribed in 15 patients (10 severe, 5 moderate; follow-up: 57 ± 17 months)...
March 6, 2024: Journal of Clinical Medicine
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JOURNAL ARTICLE
Chang Gao, Haiyan Wang, Jihui Ju, Keran Zhang, Ye Gao, Shiqi Guo, Di Yin, Ruixing Hou, Qiang Guo
PURPOSE: Even though replantation of limb mutilation is increasing, postoperative wound infection can result in increasing the financial and psychological burden of patients. Here, we sought to explore the distribution of pathogens and identify risk factors for postoperative wound infection to help early identification and managements of high-risk patients. METHODS: Adult inpatients with severed traumatic major limb mutilation who underwent replantation from Suzhou Ruixing Medical Group between November 09, 2014, and September 6, 2022 were included in this retrospective study...
2024: PloS One
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JOURNAL ARTICLE
Ladan Amirkhosravi, Mohammad Khaksari, Mojgan Sanjari, Parisa Khorasani
OBJECTIVES: Studies suggest that both genomic and nongenomic pathways are involved in mediating the salutary effects of steroids following traumatic brain injury (TBI). This study investigated the nongenomic effects of 17β-estradiol (E2) mediated by the PI3K/p-Akt pathway after TBI. METHODS: Ovariectomized rats were apportioned to E2, E2-BSA (E2 conjugated to bovine serum albumin), G1 [G-protein-coupled estrogen receptor agonist (GPER)] or their vehicle was injected following TBI, whereas ICI (classical estrogen receptor antagonist), G15 (GPER antagonist), ICI + G15, and their vehicles were injected before the induction of TBI and injection of drugs...
March 20, 2024: Hormone Molecular Biology and Clinical Investigation
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JOURNAL ARTICLE
Yiming Chen, Huiying Li, Renfeng Xu, Yan Fang, Qinhui Chen, Zhengchao Wang, Haiqing Liu, Yunxiang Weng
Emergency prehospital wound closure and hemorrhage control are the first priorities for life-saving. A majority bioadhesives form bonds with tissues through irreversible cross-linking, and the remobilization of misalignment may cause severe secondary damage to tissues. Therefore, developing an adhesive that can quickly and tolerably adhere to traumatized dynamic tissue or organ surfaces in emergency situations is a major challenge. Inspiring by the structure of human serum albumin (HSA), a branched polymer with multitentacled sulfhydryl is synthesized, then an instant and fault-tolerant tough wet-tissue adhesion (IFA) hydrogel is prepared...
March 14, 2024: Advanced Healthcare Materials
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JOURNAL ARTICLE
Yan Jiang
No abstract text is available yet for this article.
March 2024: World Neurosurgery
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JOURNAL ARTICLE
Matthew C Culkin, Priyanka Bele, Anastasia P Georges, Patricia Santos, Grace Niziolek, Lewis J Kaplan, Douglas H Smith, Jose L Pascual
BACKGROUND: Early posttraumatic brain injury (TBI) tranexamic acid (TXA) may reduce blood-brain barrier (BBB) permeability, but it is unclear if this effect is fixed regardless of dose. We hypothesized that post-TBI TXA demonstrates a dose-dependent reduction of in vivo penumbral leukocyte mobilization, BBB microvascular permeability, and enhancement of neuroclinical recovery. METHODS: CD1 male mice (n = 40) were randomly assigned to TBI by controlled cortical impact (injury [I]) or sham TBI (S), followed by intravenous bolus of either saline (placebo [P]) or TXA (15, 30, or 60 mg/kg)...
March 5, 2024: Neurocritical Care
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JOURNAL ARTICLE
Bram Akerboom, Roemer J Janse, Aurora Caldinelli, Bengt Lindholm, Joris I Rotmans, Marie Evans, Merel van Diepen
BACKGROUND AND HYPOTHESIS: Non-traumatic lower extremity amputation (LEA) is a severe complication during dialysis. To inform decision-making for physicians, we developed a multivariable prediction model for LEA after starting dialysis. METHODS: Data from the Swedish Renal Registry (SNR) between 2010 and 2020 were geographically split into a development and validation cohort. Data from NECOSAD between 1997 and 2009 were used for validation targeted at Dutch patients...
February 26, 2024: Nephrology, Dialysis, Transplantation
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REVIEW
Dayong Li, Xujie Zhang, Yuru Lu, Liang Jing, Hongjie Hu, Yaqin Song, Shuhui Wu, Wei Zhu
Post-sepsis psychiatric disorder, encompassing anxiety, depression, post-traumatic stress disorder and delirium, is a highly prevalent complication secondary to sepsis, resulting in a marked increase in long-term mortality among affected patients. Regrettably, psychiatric impairment associated with sepsis is frequently disregarded by clinicians. This review aims to summarize recent advancements in the understanding of the pathophysiology, prevention, and treatment of post-sepsis mental disorder, including coronavirus disease 2019-related psychiatric impairment...
February 21, 2024: Neurological Sciences
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JOURNAL ARTICLE
Koji Tamai, Hidetomi Terai, Hiroaki Nakamura, Noriaki Yokogawa, Takeshi Sasagawa, Hiroaki Nakashima, Naoki Segi, Sadayuki Ito, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Kota Watanabe, Junichi Yamane, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Hideaki Nakajima, Tomohiro Yamada, Tomohiko Hasegawa, Yoshinori Terashima, Ryosuke Hirota, Hidenori Suzuki, Yasuaki Imajo, Shota Ikegami, Masashi Uehara, Hitoshi Tonomura, Munehiro Sakata, Ko Hashimoto, Yoshito Onoda, Kenichi Kawaguchi, Yohei Haruta, Nobuyuki Suzuki, Kenji Kato, Hiroshi Uei, Hirokatsu Sawada, Kazuo Nakanishi, Kosuke Misaki, Akiyoshi Kuroda, Gen Inoue, Kenichiro Kakutani, Yuji Kakiuchi, Katsuhito Kiyasu, Hiroyuki Tominaga, Hiroto Tokumoto, Yoichi Iizuka, Eiji Takasawa, Koji Akeda, Norihiko Takegami, Haruki Funao, Yasushi Oshima, Takashi Kaito, Daisuke Sakai, Toshitaka Yoshii, Tetsuro Ohba, Bungo Otsuki, Shoji Seki, Masashi Miyazaki, Masayuki Ishihara, Seiji Okada, Shiro Imagama, Satoshi Kato
STUDY DESIGN: Retrospective cohort study. OBJECTIVES: To define the prognosis and predictive factors for neurological improvement in older patients with incomplete spinal cord injury (SCI) of American Spinal Injury Association Impairment Scale grade C (AIS-C). SETTINGS: Multi-institutions in Japan. METHODS: We included patients aged ≥65 years with traumatic SCI of AIS-C who were treated conservatively or surgically with >3 follow-up months...
February 12, 2024: Spinal Cord
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JOURNAL ARTICLE
Haoyue He, Jinxin Liu, Chuanming Li, Yi Guo, Kaixin Liang, Jun Du, Jun Xue, Yidan Liang, Peng Chen, Liu Liu, Min Cui, Jia Wang, Ye Liu, Shanshan Tian, Yongbing Deng
Hemorrhagic progression of contusion (HPC) often occurs early in cerebral contusions (CC) patients, significantly impacting their prognosis. It is vital to promptly assess HPC and predict outcomes for effective tailored interventions, thereby enhancing prognosis in CC patients. We utilized the Attention-3DUNet neural network to semi-automatically segment hematomas from computed tomography (CT) images of 452 CC patients, incorporating 695 hematomas. Subsequently, 1,502 radiomic features were extracted from 358 hematomas in 261 patients...
February 7, 2024: Journal of Neurotrauma
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JOURNAL ARTICLE
Pingchuan Xia, Houyuan Lv, Chenghua Yuan, Wanru Duan, Jiachen Wang, Jian Guan, Yueqi Du, Can Zhang, Zhenlei Liu, Kai Wang, Zuowei Wang, Xingwen Wang, Hao Wu, Zan Chen, Fengzeng Jian
OBJECTIVE: Surgical procedures for patients with post-traumatic syringomyelia (PTS) remain controversial. Until now, there have been no effective quantitative evaluation methods to assist in selecting appropriate surgical plans before surgery. METHODS: We consecutively enrolled PTS patients (arachnoid lysis group, n=42; shunting group, n=14) from 2003 to 2023. Additionally, 19 intrathecal anesthesia patients were included in the control group. All patients with PTS underwent physical and neurological examinations and spinal MRI preoperatively, 3-12 months postoperatively and during the last follow-up...
February 1, 2024: Neurospine
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JOURNAL ARTICLE
Yiran Guo, Yuxin Leng, Chengjin Gao
Traumatic brain injury (TBI), a major global health burden, disrupts the neurological system due to accidents and other incidents. While the Glasgow coma scale (GCS) gauges neurological function, it falls short as the sole predictor of overall mortality in TBI patients. This highlights the need for comprehensive outcome prediction, considering not just neurological but also systemic factors. Existing approaches relying on newly developed biomolecules face challenges in clinical implementation. Therefore, we investigated the potential of readily available clinical indicators, like the blood urea nitrogen-to-albumin ratio (BAR), for improved mortality prediction in TBI...
January 2, 2024: Bioengineering
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JOURNAL ARTICLE
Alexandra Hochstetler, George Price, Amy Baohan, Melissa Li, Frances Rodriguez Lara, Josephine Lok, Beth Costine-Bartell
INTRODUCTION: A striking pattern in young children after severe TBI is when the entire cortical ribbon displays tissue damage: hemispheric hypodensity (HH). HH is often a result of abusive head trauma (AHT). We previously reported a model of HH in a gyrencephalic species where a combination of injuries consisting of 1) cortical impact, 2) midline shift, 3) subdural hematoma/subarachnoid hemorrhage, 4) traumatic seizures, and 5) brief apnea and hypoventilation, resulted in extensive, hypoxic-ischemic type injury...
January 8, 2024: Developmental Neuroscience
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JOURNAL ARTICLE
Stevie Hendriks, Janice M Ranson, Kirsten Peetoom, Ilianna Lourida, Xin You Tai, Marjolein de Vugt, David J Llewellyn, Sebastian Köhler
IMPORTANCE: There is limited information on modifiable risk factors for young-onset dementia (YOD). OBJECTIVE: To examine factors that are associated with the incidence of YOD. DESIGN, SETTING, AND PARTICIPANTS: This prospective cohort study used data from the UK Biobank, with baseline assessment between 2006 and 2010 and follow-up until March 31, 2021, for England and Scotland, and February 28, 2018, for Wales. Participants younger than 65 years and without a dementia diagnosis at baseline assessment were included in this study...
December 26, 2023: JAMA Neurology
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JOURNAL ARTICLE
Haoyang Mo, Fan Fan, Jian Liu, Wenfan Zhang, Qing Wang, Xiangning Yuan
OBJECTIVE: Traumatic brain injury (TBI) is a highly prevalent neurological disorder that affects a gradually increasing proportion of older adults. Chronic kidney disease (CKD) significantly contributes to global years of life lost, with an estimated one-tenth of the global population affected by CKD. However, it remains unclear whether CKD impacts TBI prognosis. We conducted a case-control study to investigate the clinical outcomes of TBI patients with or without CKD comorbidity and identified the risk factors associated with a poor prognosis...
2023: Frontiers in Neurology
#18
JOURNAL ARTICLE
Hiroki Ushirozako, Kota Suda, Satoko Matsumoto Harmon, Miki Komatsu, Masahiro Ota, Tomoaki Shimizu, Akio Minami, Masahiko Takahata, Norimasa Iwasaki, Yukihiro Matsuyama
INTRODUCTION: Epidemic preventive management during the coronavirus disease 2019 (COVID-19) pandemic may have negatively impacted perioperative outcomes in patients with traumatic spinal cord injury (SCI). However, little is known about the relationship between epidemic preventive management and delirium after traumatic SCI. Here, we clarified the predictors of delirium after SCI surgery. METHODS: We retrospectively analyzed 231 patients (mean age, 66 years) who underwent SCI surgery between 2017 and 2021...
November 27, 2023: Spine surgery and related research
#19
JOURNAL ARTICLE
Faezeh Gouhari, Reza Zandi, Amir Mehrvar, Shahin Talebi, Zahra Vahdat Shariatpanahi
OBJECTIVES: Patients with femur fracture after surgery are at risk of malnutrition, weight loss, disability, and mobility complications. In the present study the role of colostrum supplementation on physical disability, and some nutritional variables after surgery has been investigated. RESEARCH METHODS & PROCEDURES: Patients were randomly assigned to two groups. The intervention group received 45 g colostrum and the control group received 15 g whey protein daily for 21 days (each containing 12 g of protein)...
November 30, 2023: Injury
#20
JOURNAL ARTICLE
Chenghua Yuan, Pingchuan Xia, Wanru Duan, Jiachen Wang, Jian Guan, Yueqi Du, Can Zhang, Zhenlei Liu, Kai Wang, Zuowei Wang, Xingwen Wang, Hao Wu, Zan Chen, Fengzeng Jian
STUDY DESIGN: Cohort study. OBJECTIVE: The aim of this study was to explore the association between blood spinal cord barrier (BSCB) markers and other factors associated with unfavorable outcome among patients with post-traumatic syringomyelia (PTS) who achieved successful intradural adhesion lysis (IAL). SUMMARY OF BACKGROUND DATA: Only approximately half of PTS patients receiving IAL have a favorable outcome. METHODS: Forty-six consecutive patients with PTS and 19 controls (CTRL) were enrolled...
November 28, 2023: Spine
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