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https://www.readbyqxmd.com/read/29318084/how-does-frailty-factor-into-mortality-risk-assessment-of-a-middle-aged-and-geriatric-trauma-population
#1
Sanjit R Konda, Ariana Lott, Hesham Saleh, Sebastian Schubl, Jeffrey Chan, Kenneth A Egol
Introduction: Frailty in elderly trauma populations has been correlated with an increased risk of morbidity and mortality. The Score for Trauma Triage in the Geriatric and Middle-Aged (STTGMA) is a validated mortality risk score that evaluates 4 major physiologic criteria: age, comorbidities, vital signs, and anatomic injuries. The aim of this study was to investigate whether the addition of additional frailty variables to the STTGMA tool would improve risk stratification of a middle-aged and elderly trauma population...
December 2017: Geriatric Orthopaedic Surgery & Rehabilitation
https://www.readbyqxmd.com/read/29285620/effect-of-the-combined-treatment-of-albumin-with-plasma-synthesised-pyrrole-polymers-on-motor-recovery-after-traumatic-spinal-cord-injury-in-rats
#2
Omar Fabela-Sánchez, Hermelinda Salgado-Ceballos, Luis Medina-Torres, Laura Álvarez-Mejía, Stephany Sánchez-Torres, Rodrigo Mondragón-Lozano, Axayácatl Morales-Guadarrama, Araceli Díaz-Ruiz, María-Guadalupe Olayo, Guillermo J Cruz, Juan Morales, Camilo Ríos, Roberto Olayo
Traumatic spinal cord injury (TSCI) is a health problem for which there is currently no treatment or definitive therapy. Medicine has explored therapeutic options for patients with TSCI with the aim to improve their quality of life. One alternative has been the development of biomaterials that offer neuroprotection or neuroregeneration of damaged nerve tissue. The microinjection of iodine-doped polypyrrole particles synthesised by plasma (PPPy/I) has shown neuroprotective effects that favour motor function recovery in experimental animals with TSCI...
December 28, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29276840/serum-albumin-predicts-long-term-neurological-outcomes-after-acute-spinal-cord-injury
#3
Bobo Tong, Catherine R Jutzeler, Jacquelyn J Cragg, Lukas Grassner, Jan M Schwab, Steve Casha, Fred Geisler, John L K Kramer
BACKGROUND: There is a need to identify reliable biomarkers of spinal cord injury recovery for clinical practice and clinical trials. OBJECTIVE: Our objective was to correlate serum albumin levels with spinal cord injury neurological outcomes. METHODS: We performed a secondary analysis of patients with traumatic spinal cord injury (n = 591) participating in the Sygen clinical trial. Serum albumin concentrations were obtained as part of routine blood chemistry analysis, at trial entry (24-72 hours), 1, 2, and 4 weeks after injury...
December 1, 2017: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29247482/commonalities-in-epileptogenic-processes-from-different-acute-brain-insults-do-they-translate
#4
REVIEW
Pavel Klein, Raymond Dingledine, Eleonora Aronica, Christophe Bernard, Ingmar Blümcke, Detlev Boison, Martin J Brodie, Amy R Brooks-Kayal, Jerome Engel, Patrick A Forcelli, Lawrence J Hirsch, Rafal M Kaminski, Henrik Klitgaard, Katja Kobow, Daniel H Lowenstein, Phillip L Pearl, Asla Pitkänen, Noora Puhakka, Michael A Rogawski, Dieter Schmidt, Matti Sillanpää, Robert S Sloviter, Christian Steinhäuser, Annamaria Vezzani, Matthew C Walker, Wolfgang Löscher
The most common forms of acquired epilepsies arise following acute brain insults such as traumatic brain injury, stroke, or central nervous system infections. Treatment is effective for only 60%-70% of patients and remains symptomatic despite decades of effort to develop epilepsy prevention therapies. Recent preclinical efforts are focused on likely primary drivers of epileptogenesis, namely inflammation, neuron loss, plasticity, and circuit reorganization. This review suggests a path to identify neuronal and molecular targets for clinical testing of specific hypotheses about epileptogenesis and its prevention or modification...
December 15, 2017: Epilepsia
https://www.readbyqxmd.com/read/29165777/the-use-of-crystalloids-in-traumatic-brain-injury
#5
Wojciech Dąbrowski, Tom Woodcock, Ziemowit Rzecki, Manu L N G Malbrain
Fluid therapy is one of the most important treatments in patients with traumatic brain injury (TBI) as both hypo- and hypervolaemia can cause harm. The main goals of fluid therapy for patients with TBI are to optimize cerebral perfusion and to maintain adequate cerebral oxygenation. The avoidance of cerebral oedema is clearly essential. The current weight of evidence in the published literature suggests that albumin therapy is harmful and plasma substitutes have failed to demonstrate superiority over crystalloids solutions...
November 22, 2017: Anaesthesiology Intensive Therapy
https://www.readbyqxmd.com/read/29057992/nutritional-blood-parameters-and-nutritional-risk-screening-in-patients-with-spinal-cord-injury-and-deep-pressure-ulcer-a-retrospective-chart-analysis
#6
Cristina Lussi, Angela Frotzler, Andreas Jenny, Dirk J Schaefer, Reto W Kressig, Anke Scheel-Sailer
STUDY DESIGN: Retrospective chart review. OBJECTIVES: To describe (i) the nutritional blood parameters (NBP) and the nutritional risk screening (NRS) in patients with spinal cord injury (SCI) and pressure ulcers (PU) III and IV according to the EPUAP classification, and (ii) the relationship between both NBP and NRS. SETTING: SCI acute care and rehabilitation clinic in Switzerland. METHODS: The NBPs were measured upon the admission of patients treated for PU III and IV between 11/2011 and 12/2014...
October 23, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29049135/early-identification-of-the-patient-with-endotheliopathy-of-trauma-by-arrival-serum-albumin
#7
Erika Gonzalez Rodriguez, Jessica C Cardenas, Ernesto Lopez, Bryan A Cotton, Jeffrey S Tomasek, Sisse R Ostrowski, Lisa A Baer, Jakob Stensballe, John B Holcomb, Pär I Johansson, Charles E Wade
OBJECTIVE: Traumatic endotheliopathy (EoT) is associated with glycocalyx breakdown and capillary leak resulting in the extravasation of proteins. We hypothesized that lower serum albumin levels are associated with EoT, poor outcomes, and can be used for early EoT screening in trauma patients. METHODS: We enrolled severely injured trauma patients with serum albumin levels available on admission. Syndecan-1 and soluble thrombomodulin were quantified from plasma by ELISA...
October 18, 2017: Shock
https://www.readbyqxmd.com/read/28935352/post-traumatic-cervical-spine-epidural-hematoma-incidence-and-risk-factors
#8
Pedro A Ricart, Ravi Verma, Steven J Fineberg, Kyle Y Fink, Paul A Lucas, Yungtai Lo, David E Asprinio, Louis F Amorosa
BACKGROUND: The incidence and risk factors for post-traumatic cervical epidural hematoma are not well described in the current literature. Our aim was to determine the incidence and associated risk factors for post-traumatic cervical spine epidural hematoma (SEH). METHODS: We performed a retrospective review of our institution's prospectively collected data submitted to the state trauma registry, using ICD-9 codes, for all patients activated as a trauma with cervical spine injuries, between the years 2010 and 2014...
November 2017: Injury
https://www.readbyqxmd.com/read/28856586/tio2-nanowired-delivery-of-dl-3-n-butylphthalide-dl-nbp-attenuates-blood-brain-barrier-disruption-brain-edema-formation-and-neuronal-damages-following-concussive-head-injury
#9
Lianyuan Feng, Aruna Sharma, Feng Niu, Yin Huang, José Vicente Lafuente, Dafin Fior Muresanu, Asya Ozkizilcik, Z Ryan Tian, Hari Shanker Sharma
DL-3-n-butylphthalide (DL-NBP) is one of the constituents of Chinese celery extract that is used to treat stroke, dementia, and ischemic diseases. However, its role in traumatic brain injury is less well known. In this investigation, neuroprotective effects of DL-NBP in concussive head injury (CHI) on brain pathology were explored in a rat model. CHI was inflicted in anesthetized rats by dropping a weight of 114.6 g from a height of 20 cm through a guide tube on the exposed right parietal bone inducing an impact of 0...
August 30, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28856566/cold-environment-exacerbates-brain-pathology-and-oxidative-stress-following-traumatic-brain-injuries-potential-therapeutic-effects-of-nanowired-antioxidant-compound-h-290-51
#10
Aruna Sharma, Dafin F Muresanu, José Vicente Lafuente, Per-Ove Sjöquist, Ranjana Patnaik, Z Ryan Tian, Asya Ozkizilcik, Hari S Sharma
The possibility that traumatic brain injury (TBI) occurring in a cold environment exacerbates brain pathology and oxidative stress was examined in our rat model. TBI was inflicted by making a longitudinal incision into the right parietal cerebral cortex (2 mm deep and 4 mm long) in cold-acclimatized rats (5 °C for 3 h daily for 5 weeks) or animals at room temperature under Equithesin anesthesia. TBI in cold-exposed rats exhibited pronounced increase in brain lucigenin (LCG), luminol (LUM), and malondialdehyde (MDA) and marked pronounced decrease in glutathione (GTH) as compared to identical TBI at room temperature...
August 30, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28794441/tgf%C3%AE-signaling-is-associated-with-changes-in-inflammatory-gene-expression-and-perineuronal-net-degradation-around-inhibitory-neurons-following-various-neurological-insults
#11
Soo Young Kim, Vladimir V Senatorov, Christapher S Morrissey, Kristina Lippmann, Oscar Vazquez, Dan Z Milikovsky, Feng Gu, Isabel Parada, David A Prince, Albert J Becker, Uwe Heinemann, Alon Friedman, Daniela Kaufer
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term disability, often leads to the development of epilepsy. Patients who develop post-injury epilepsy tend to have poor functional outcomes. Emerging evidence highlights a potential role for blood-brain barrier (BBB) dysfunction in the development of post-injury epilepsy. However, common mechanisms underlying the pathological hyperexcitability are largely unknown. Here, we show that comparative transcriptome analyses predict remodeling of extracellular matrix (ECM) as a common response to different types of injuries...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28664332/heparin-gold-nanoparticles-for-enhanced-microdialysis-sampling
#12
Susan Giorgi-Coll, Holly Blunt-Foley, Peter J Hutchinson, Keri L H Carpenter
Cerebral microdialysis is a sampling technique which offers much potential for understanding inflammatory pathophysiology following traumatic brain injury (TBI). At present, the recovery of cytokines via microdialysis in clinical studies is not straightforward primarily due to their size, steric properties and low concentrations. Heparin and heparin-coated microspheres have previously shown promise as cytokine-binding agents for enhanced microdialysis sampling in animal models (Duo and Stenken in Anal Bioanal Chem 399(2):773-82, 2011; Anal Bioanal Chem 399(2):783-93, 2011)...
August 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28619005/effects-of-immunonutrition-on-biomarkers-in-traumatic-brain-injury-patients-in-malaysia-a-prospective-randomized-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Vineya Rai Hakumat Rai, Lee Fern Phang, Sheau Fung Sia, Amirah Amir, Jeyaganesh S Veerakumaran, Mustafa Kassim Abdulazez Kassim, Rafidah Othman, Pei Chien Tah, Pui San Loh, Mohamad Irfan Othman Jailani, Gracie Ong
BACKGROUND: Head injury is one of the top three diagnosis leading to intensive care unit (ICU) admission in Malaysia. There has been growing interest in using immunonutrition as a mode of modulating the inflammatory response to injury or infection with the aim of improving clinical outcome. The aim of the present study was to evaluate the effect of an immunonutrition on biomarkers (IL-6, glutathione, CRP, total protein and albumin) in traumatic brain injury patients. METHODS: Thirty six patients with head injury admitted to neurosurgical ICU in University Malaya Medical Centre were recruited for this study, over a 6-month period from July 2014 to January 2015...
June 15, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28587357/differential-proteomic-screening-and-identification-for-non-traumatic-necrotic-femoral-osseous-tissue
#14
Peng Yan, Yeping Zhu, Hui Zhao, Yanyan Lu, Yuzhong Gao
Currently, there is a lack of effective early screening and detection methods for femoral head necrosis. Current research on most orthopedic diseases focuses on proteomics in the preliminary stage. The recent fluorescence differential in gel electrophoresis (DIGE) has advantages such as a high reproducibility, high sensitivity, high throughput, and high dynamic range. It is currently one of the most widely used quantitative proteomic research means. We conducted this study to investigate the pathogenesis of non-traumatic femoral head necrosis using the fluorescence DIGE to screen non-traumatic femoral head necrosis based on proteomics and provide a theoretical basis for screening possible biomarkers and molecular targeted treatment...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28498856/patterns-of-intravenous-fluid-resuscitation-use-in-adult-intensive-care-patients-between-2007-and-2014-an-international-cross-sectional-study
#15
Naomi E Hammond, Colman Taylor, Simon Finfer, Flavia R Machado, YouZhong An, Laurent Billot, Frank Bloos, Fernando Bozza, Alexandre Biasi Cavalcanti, Maryam Correa, Bin Du, Peter B Hjortrup, Yang Li, Lauralyn McIntryre, Manoj Saxena, Frédérique Schortgen, Nicola R Watts, John Myburgh
BACKGROUND: In 2007, the Saline versus Albumin Fluid Evaluation-Translation of Research Into Practice Study (SAFE-TRIPS) reported that 0.9% sodium chloride (saline) and hydroxyethyl starch (HES) were the most commonly used resuscitation fluids in intensive care unit (ICU) patients. Evidence has emerged since 2007 that these fluids are associated with adverse patient-centred outcomes. Based on the published evidence since 2007, we sought to determine the current type of fluid resuscitation used in clinical practice and the predictors of fluid choice and determine whether these have changed between 2007 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28411452/peptide-valency-plays-an-important-role-in-the-activity-of-a-synthetic-fibrin-crosslinking-polymer
#16
Robert J Lamm, Esther B Lim, Katie M Weigandt, Lilo D Pozzo, Nathan J White, Suzie H Pun
Therapeutic polymers have the potential to improve the standard of care for hemorrhage, or uncontrolled bleeding, as synthetic hemostats. PolySTAT, a fibrin-crosslinking peptide-polymer conjugate, has the capacity to rescue fibrin clot formation and improve survival in a model of acute traumatic bleeding. PolySTAT consists of a synthetic polymer backbone to which targeting fibrin-binding peptides are linked. For translation of PolySTAT, the optimal valency of peptides must be determined. Grafting of fibrin-binding peptides to the poly(hydroxyethyl methacrylate)-based backbone was controlled to produce peptide valencies ranging from 0 to 10 peptides per polymer...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28287384/effects-of-potassium-adsorption-filters-on-the-removal-of-ammonia-from-blood-products
#17
Hiroshi Fujita, Yoko Shiotani, Yuko Takada, Shigeko Nishimura
BACKGROUND: Although ammonia in plasma does not usually pass through the blood-brain barrier (BBB), in cases of traumatic brain injury it may do so, acting as a neurotoxin on the brain. Excess intake of ammonia should be restricted in conditions involving BBB breakdown, such as traumatic brain injury. Washing is a method to remove ammonia from blood products, but fresh-frozen plasma and albumin products cannot be washed. A potassium adsorption filter (PAF) can remove not only potassium, but also ammonia from red blood cell solutions...
March 1, 2017: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/28283595/astroglial-activation-and-altered-amyloid-metabolism-in-human-repetitive-concussion
#18
MULTICENTER STUDY
Pashtun Shahim, Yelverton Tegner, Niklas Marklund, Kina Höglund, Erik Portelius, David L Brody, Kaj Blennow, Henrik Zetterberg
OBJECTIVE: To determine whether postconcussion syndrome (PCS) due to repetitive concussive traumatic brain injury (rcTBI) is associated with CSF biomarker evidence of astroglial activation, amyloid deposition, and blood-brain barrier (BBB) impairment. METHODS: A total of 47 participants (28 professional athletes with PCS and 19 controls) were assessed with lumbar puncture (median 1.5 years, range 0.25-12 years after last concussion), standard MRI of the brain, and Rivermead Post-Concussion Symptoms Questionnaire (RPQ)...
April 11, 2017: Neurology
https://www.readbyqxmd.com/read/28279078/nano-carrier-mediated-co-delivery-of-methyl-prednisolone-and-minocycline-for-improved-post-traumatic-spinal-cord-injury-conditions-in-rats
#19
Shen Bin, Ningfeng Zhou, Jie Pan, Fumin Pan, Xiao-Feng Wu, Zi-Hui Zhou
OBJECTIVE: The objective of this study is to investigate the fate of albumin coupled nanoparticulate system over non-targeted drug carrier in the treatment of hemisectioned spinal cord injury (SCI). SIGNIFICANCE: Targeted delivery of methyl prednisolone (MP) and minocycline (MC) portrayed improved therapeutic efficacy as compared with non-targeted nanoparticles (NPS). METHODS: Albumin coupled, chitosan stabilized, and cationic NPS (albumin-MP + MC - NPS) of poly-(lactide-co-glycolic acid) were prepared using the emulsion solvent evaporation method...
June 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28219400/alleviation-of-secondary-brain-injury-posttraumatic-inflammation-and-brain-edema-formation-by-inhibition-of-factor-xiia
#20
Sarah Hopp, Marc W Nolte, Christian Stetter, Christoph Kleinschnitz, Anna-Leena Sirén, Christiane Albert-Weissenberger
BACKGROUND: Traumatic brain injury (TBI) is a devastating neurological condition and a frequent cause of permanent disability. Posttraumatic inflammation and brain edema formation, two pathological key events contributing to secondary brain injury, are mediated by the contact-kinin system. Activation of this pathway in the plasma is triggered by activated factor XII. Hence, we set out to study in detail the influence of activated factor XII on the abovementioned pathophysiological features of TBI...
February 20, 2017: Journal of Neuroinflammation
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