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https://www.readbyqxmd.com/read/28927232/association-between-intradialytic-central-venous-oxygen-saturation-and-ultrafiltration-volume-in-chronic-hemodialysis-patients
#1
Hanjie Zhang, Lili Chan, Anna Meyring-Wösten, Israel Campos, Priscila Preciado, Jeroen P Kooman, Frank M van der Sande, Doris Fuertinger, Stephan Thijssen, Peter Kotanko
Background: Cardiac disease is highly prevalent in hemodialysis (HD) patients. Decreased tissue perfusion, including cardiac, due to high ultrafiltration volumes (UFVs) is considered to be one of the drivers of cardiac dysfunction. While central venous oxygen saturation (ScvO 2 ) is frequently used as an indicator of cardiac output in non-uremic populations, the relationship of ScvO 2 and UFV in HD patients remains unclear. Our aim was to determine how intradialytic ScvO 2 changes associate with UFV...
September 12, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28926709/simulating-osmotic-equilibria-a-new-tool-to-calculate-activity-coefficients-in-concentrated-aqueous-salt-solutions
#2
Michael Bley, Magali Duvail, Philippe Guilbaud, Jean-Francois Dufrêche
Herein, a new theoretical method simulating osmotic equilibria and activities is presented, where a bulk liquid and its corresponding vapor phase are simulated with molecular dynamics using polarizable force fields. Time-averaged number density profiles based on the resulting trajectories provide the amount of evaporated molecules present in the vapor phase and consequently the vapor phase density. The activity of the solvent and the corresponding osmotic coefficient are determined by the vapor density at a certain solute concentration with respect to the reference vapor density of the pure solvent...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926596/bifurcation-kinetics-of-drug-uptake-by-gram-negative-bacteria
#3
David A Westfall, Ganesh Krishnamoorthy, David Wolloscheck, Rupa Sarkar, Helen I Zgurskaya, Valentin V Rybenkov
Cell envelopes of many bacteria consist of two membranes studded with efflux transporters. Such organization protects bacteria from the environment and gives rise to multidrug resistance. We report a kinetic model that accurately describes the permeation properties of this system. The model predicts complex non-linear patterns of drug uptake complete with a bifurcation, which recapitulate the known experimental anomalies. We introduce two kinetic parameters, the efflux and barrier constants, which replace those of Michaelis and Menten for trans-envelope transport...
2017: PloS One
https://www.readbyqxmd.com/read/28926254/new-in-situ-measurements-of-the-viscosity-of-gas-clathrate-hydrate-slurries-formed-from-model-water-in-oil-emulsions
#4
Ahmad Majid, David T Wu, Carolyn A Koh
In-situ rheological measurements for clathrate hydrate slurries were performed using a high pressure rheometer to determine the effect of hydrate particles on the viscosity and transportability of these slurries. These measurements were conducted using a well-characterized model water-in-oil emulsion1. The emulsion consists of a model liquid hydrocarbon, water, and a surfactant mixture of sorbitane monooleate 80 (Span 80) and sodium di-2-ethylhexylsulfosuccinate (Aerosol OT, AOT). This emulsion was used as an analog to water-in-crude oil (w/o) emulsions and provides reproducible results...
September 19, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28926151/hospital-in-the-home-nurses-recognition-and-response-to-clinical-deterioration
#5
Erika Gray, Judy Currey, Julie Considine
AIMS AND OBJECTIVES: To obtain an understanding of how HITH (Hospital in the Home) nurses recognise and respond to clinical deterioration in patients receiving care at home or in their usual place of residence. BACKGROUND: Recognising and responding to clinical deterioration is an international safety priority and a key nursing responsibility. Despite an increase in care delivery in home environments, how HITH nurses recognise and respond to clinical deterioration is not yet fully understood...
September 19, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28925893/big-data-analyses-for-continuous-evaluation-of-pharmacotherapy-a-proof-of-principle-with-doxapram-in-preterm-infants
#6
Robert Flint, Willem van Weteringen, Swantje Völler, Jarinda A Poppe, Birgit Cp Koch, Ronald de Groot, Dick Tibboel, Catherijne Aj Knibbe, Irwin Km Reiss, Sinno Hp Simons
BACKGROUND: Drug effect evaluation is often based on subjective interpretation of a selection of patient data. Continuous analyses of high frequency patient monitor data are a valuable source to measure drug effects. However, these have not yet been fully explored in clinical care. We aim to evaluate the usefulness and applicability of high frequency physiological data for analyses of pharmacotherapy. METHODS: As a proof of principle, the effects of doxapram, a respiratory stimulant, on the oxygenation in preterm infants were studied...
September 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28925545/methane-delays-the-senescence-and-browning-in-daylily-buds-by-re-established-redox-homeostasis
#7
Huali Hu, Dan Liu, Pengxia Li
BACKGROUND: During the postharvest senescence of fruits and vegetables, redox imbalance occurs. Although the release of methane (CH4 ) has been observed for a long time and its antioxidant properties have recently been demonstrated in animals and plants, the corresponding physiological role of CH4 in regulating plant senescence has not yet been elucidated. RESULTS: Here, our results indicate that the postharvest deterioration of daylily buds during storage is greatly ameliorated by the exogenous application of CH4 , particularly in the inhibition of tissue browning...
September 19, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28925262/magnetic-properties-of-cofe2o4-thin-films-synthesized-by-radical-enhanced-atomic-layer-deposition
#8
Calvin D Pham, Jeffrey Chang, Mark A Zurbuchen, Jane P Chang
A radical enhanced atomic layer deposition (RE-ALD) process was developed for growing ferrimagnetic CoFe2O4 thin films. By utilizing bis(2,2,6,6-tetramethyl-3,5-heptanedionato) cobalt (II) (Co(TMHD)2), Fe(TMHD)3, and atomic oxygen as the metal and oxidation sources respectively, amorphous and stoichiometric CoFe2O4 films were deposited onto SrTiO3 (001) substrates at 200 °C. The RE-ALD growth rate obtained for CoFe2O4 is ~2.4 Å/supercycle, significantly higher than the values reported for thermally activated ALD processes...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28925004/size-dependent-reactivity-of-nano-sized-neutral-manganese-oxide-clusters-toward-ethylene
#9
Jiao-Jiao Chen, Ting Zhang, Mei-Qi Zhang, Qing-Yu Liu, Xiao-Na Li, Sheng-Gui He
Neutral manganese oxide clusters Mn2NO3N+x (N = 2-22; x = -1, 0, 1) with dimensions up to a nanosize were prepared by laser ablation and reacted with C2H4 in a fast flow reactor. The size-dependent reactivity of C2H4 adsorption on these clusters was experimentally identified and the adsorption reactivity decreases generally with the increase of cluster size. Density functional theory calculations were performed to study the geometrical and electronic structures of Mn2NO3N (N = 1-6) clusters. The calculated results indicated that the coordination number and the charge distribution of the metal centers are responsible for the experimentally observed size-dependent reactivity...
September 19, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28924565/nirs-based-cerebrovascular-regulation-assessment-exercise-and-cerebrovascular-reactivity
#10
Stephanie Miller, Kunal Mitra
Alterations to cerebral blood flow (CBF) have been implicated in diverse neurological conditions. Near-infrared spectroscopy (NIRS)-measured regional cerebral tissue oxygen saturation ([Formula: see text]) provides an estimate of oxygenation of interrogated cerebral volume useful in identifying variations in oxygen supply to cerebral tissue and in monitoring cerebrovascular function. [Formula: see text]-inhalation-based hypercapnic breathing challenges were used to simulate CBF dysregulation, utilizing NIRS to monitor the CBF autoregulatory response...
October 2017: Neurophotonics
https://www.readbyqxmd.com/read/28924490/the-lauric-acid-activated-signaling-prompts-apoptosis-in-cancer-cells
#11
Rosamaria Lappano, Anna Sebastiani, Francesca Cirillo, Damiano Cosimo Rigiracciolo, Giulia Raffaella Galli, Rosita Curcio, Roberta Malaguarnera, Antonino Belfiore, Anna Rita Cappello, Marcello Maggiolini
The saturated medium-chain fatty-acid lauric acid (LA) has been associated to certain health-promoting benefits of coconut oil intake, including the improvement of the quality of life in breast cancer patients during chemotherapy. As it concerns the potential to hamper tumor growth, LA was shown to elicit inhibitory effects only in colon cancer cells. Here, we provide novel insights regarding the molecular mechanisms through which LA triggers antiproliferative and pro-apoptotic effects in both breast and endometrial cancer cells...
2017: Cell Death Discovery
https://www.readbyqxmd.com/read/28924245/understanding-the-factors-affecting-self-management-of-copd-from-the-perspectives-of-healthcare-practitioners-a-qualitative-study
#12
Oladapo J Ogunbayo, Sian Russell, James J Newham, Karen Heslop-Marshall, Paul Netts, Barbara Hanratty, Eileen Kaner
Self-management is recognised as an essential criteria for the provision of high quality care for chronic obstructive pulmonary disease (COPD). The management of COPD is usually delivered by a wide range of healthcare practitioners. This study aimed to understand the factors affecting self-management of COPD from the perspectives of the different multidisciplinary healthcare teams involved in COPD care. Semi-structured interviews were conducted with participants from primary care, specialist respiratory and pulmonary rehabilitation (PR) teams...
September 18, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/28924078/partial-hydrogenation-of-sunflower-oil-derived-fames-catalyzed-by-the-efficient-and-recyclable-palladium-nanoparticles-in-polyethylene-glycol
#13
Wei Liu, Guanghui Lu
One approach to improve the oxidative stability of biodiesel is the partial hydrogenation of carbon-carbon double bonds. In the current work, an efficient catalytic system using Pd(OAc)2 dissolved in polyethylene glycol (PEG) which in situ generates palladium nanoparticles was developed in order to promote a selective partial hydrogenation reaction of sunflower oil FAMEs into mono-hydrogenated products avoiding the formation of saturated compounds or trans-isomers. High content of methyl oleate (85.0±1.4%) was obtained by hydrogenation of sunflower oil biodiesel with only 7...
September 15, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28923929/exceptionally-tight-membrane-binding-may-explain-the-key-role-of-the-synaptotagmin-7-c2a-domain-in-asynchronous-neurotransmitter-release
#14
Rashmi Voleti, Diana R Tomchick, Thomas C Südhof, Josep Rizo
Synaptotagmins (Syts) act as Ca(2+) sensors in neurotransmitter release by virtue of Ca(2+)-binding to their two C2 domains, but their mechanisms of action remain unclear. Puzzlingly, Ca(2+)-binding to the C2B domain appears to dominate Syt1 function in synchronous release, whereas Ca(2+)-binding to the C2A domain mediates Syt7 function in asynchronous release. Here we show that crystal structures of the Syt7 C2A domain and C2AB region, and analyses of intrinsic Ca(2+)-binding to the Syt7 C2 domains using isothermal titration calorimetry, did not reveal major differences that could explain functional differentiation between Syt7 and Syt1...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923780/effect-of-cpap-on-sleep-spindles-in-patients-with-osa
#15
Ozkan Yetkin, Deniz Aydoagn
OBJECTIVE: Consequences of OSAS include excessive daytime sleepiness, divided sleep architecture, impaired neurocognitive performance, and significant psychosocial disruption. In this study we aimed to evaluate sleep spindles changes before and after PAP treatment in patient with OSA. METHODS: Seventy-three consecutive patients (M/F:61/12) who applied to Sleep Disorders Center of Inonu University Hospital and met the inclusion criteria were enrolled to this study...
September 15, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28923777/an-improved-method-for-permeability-estimation-of-the-bioclastic-limestone-reservoir-based-on-nmr-data
#16
Xinmin Ge, Yiren Fan, Jianyu Liu, Li Zhang, Yujiao Han, Donghui Xing
Permeability is an important parameter in formation evaluation since it controls the fluid transportation of porous rocks. However, it is challengeable to compute the permeability of bioclastic limestone reservoirs by conventional methods linking petrophysical and geophysical data, due to the complex pore distributions. A new method is presented to estimate the permeability based on laboratory and downhole nuclear magnetic resonance (NMR) measurements. We divide the pore space into four intervals by the inflection points between the pore radius and the transversal relaxation time...
September 9, 2017: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/28923687/thermotropic-properties-of-phosphatidylcholine-nanodiscs-bounded-by-styrene-maleic-acid-copolymers
#17
J J Dominguez Pardo, J M Dörr, M F Renne, T Ould-Braham, M C Koorengevel, M J van Steenbergen, J A Killian
Styrene-maleic acid copolymers (SMA) have been gaining interest in the field of membrane research due to their ability to solubilize membranes into nanodics. The SMA molecules act as an amphipathic belt that surrounds the nanodiscs, whereby the hydrophobic styrene moieties can insert in between the lipid acyl chains. Here we used SMA variants with different styrene-to-maleic acid ratio (i.e. 2:1, 3:1 and 4:1) to investigate how lipid packing in the nanodiscs is affected by the presence of the polymers and how it depends on polymer composition...
September 15, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28923662/selecting-of-a-cytochrome-p450cam-sesam-library-with-3-chloroindole-and-endosulfan-identification-of-mutants-that-dehalogenate-3-chloroindole
#18
Shaima Kammoonah, Brinda Prasad, Priyadarshini Balaraman, Hemanshu Mundhada, Ulrich Schwaneberg, Erika Plettner
Cytochrome P450cam (a camphor hydroxylase) from the soil bacterium Pseudomonas putida shows potential importance in environmental applications such as the degradation of chlorinated organic pollutants. Seven P450cam mutants generated from Sequence Saturation Mutagenesis (SeSaM) and isolated by selection on minimal media with either 3-chloroindole or the insecticide endosulfan were studied for their ability to oxidize of 3-chloroindole to isatin. The wild-type enzyme did not accept 3-chloroindole as a substrate...
September 15, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28923611/cerebral-oximetry-as-an-auxiliary-diagnostic-tool-in-the-diagnosis-of-brain-death
#19
O Tatli, O Bekar, M Imamoglu, O Gonenc Cekic, A Aygun, U Eryigit, Y Karaca, A Sahin, S Turkmen, S Turedi
AIM: To investigate the efficacy of cerebral oximetry (CO) as an auxiliary diagnostic tool in brain death (BD). MATERIALS AND METHODS: This observational case-control study was performed on patients with suspected BD. Patients with diagnosis of BD confirmed by the brain death committee were enrolled as the BD group and other patients as the non-BD group. CO monitoring was performed at least 6 h, and cerebral tissue oxygen saturation (ScO2) parameters were compared...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28923493/diagnosis-and-quantification-of-the-iron-overload-through-magnetic-resonance
#20
J M Alústiza Echeverría, M C Barrera Portillo, A Guisasola Iñiguiz, A Ugarte Muño
There are different magnetic resonance techniques and models to quantify liver iron concentration. T2 relaxometry methods evaluate the iron concentration in the myocardium, and they are able to discriminate all the levels of iron overload in the liver. Signal intensity ratio methods saturate with high levels of liver overload and can not assess iron concentration in the myocardium but they are more accessible and are very standardized. This article reviews, in different clinical scenarios, when Magnetic Resonance must be used to assess iron overload in the liver and myocardium and analyzes the current challenges to optimize the aplication of the technique and to be it included in the clinical guidelines...
September 15, 2017: Radiología
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