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https://www.readbyqxmd.com/read/28449400/a-novel-implementation-strategy-in-residential-care-settings-to-promote-ebp-direct-care-provider-perceptions-and-development-of-a-conceptual-framework
#1
Susan E Slaughter, Erin Bampton, Daniel F Erin, Carla Ickert, C Allyson Jones, Carole A Estabrooks
BACKGROUND: Innovative approaches are required to facilitate the adoption and sustainability of evidence-based care practices. We propose a novel implementation strategy, a peer reminder role, which involves offering a brief formal reminder to peers during structured unit meetings. AIMS: This study aims to (a) identify healthcare aide (HCA) perceptions of a peer reminder role for HCAs, and (b) develop a conceptual framework for the role based on these perceptions...
April 27, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28449373/biophysical-analysis-of-the-dynamics-of-calmodulin-interactions-with-neurogranin-and-ca2-calmodulin-dependent-kinase-ii
#2
Christian Seeger, Vladimir O Talibov, U Helena Danielson
Calmodulin (CaM) functions depend on interactions with CaM-binding proteins, regulated by Ca2+. Induced structural changes influence the affinity, kinetics, and specificities of the interactions. The dynamics of CaM interactions with neurogranin (Ng) and the CaM-binding region of Ca2+/calmodulin-dependent kinase II (CaMKII290-309 ) have been studied using biophysical methods. These proteins have opposite Ca2+ dependencies for CaM binding. Surface plasmon resonance biosensor analysis confirmed that Ca2+ and CaM interact very rapidly, and with moderate affinity ( KDSPR=3μM)...
April 27, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28448934/release-of-dissolved-phosphorus-from-riparian-wetlands-evidence-for-complex-interactions-among-hydroclimate-variability-topography-and-soil-properties
#3
Sen Gu, Gérard Gruau, Rémi Dupas, Cornélia Rumpel, Alexandra Crème, Ophélie Fovet, Chantal Gascuel-Odoux, Laurent Jeanneau, Guillaume Humbert, Patrice Petitjean
In agricultural landscapes, establishment of vegetated buffer zones in riparian wetlands (RWs) is promoted to decrease phosphorus (P) emissions because RWs can trap particulate P from upslope fields. However, long-term accumulation of P risks the release of dissolved P, since the unstable hydrological conditions in these zones may mobilize accumulated particulate P by transforming it into a mobile dissolved P species. This study evaluates how hydroclimate variability, topography and soil properties interact and influence this mobilization, using a three-year dataset of molybdate-reactive dissolved P (MRDP) and total dissolved P (TDP) concentrations in soil water from two RWs located in an agricultural catchment in western France (Kervidy-Naizin), along with stream P concentrations...
April 24, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28448834/cmc-prediction-for-ionic-surfactants-in-pure-water-and-aqueous-salt-solutions-based-solely-on-tabulated-molecular-parameters
#4
Stoyan I Karakashev, Stoyan K Smoukov
The critical micelle concentration (CMC) of various surfactants is difficult to predict accurately, yet often necessary to do in both industry and science. Hence, quantum-chemical software packages for precise calculation of CMC were developed, but they are expensive and time consuming. We show here an easy method for calculating CMC with a reasonable accuracy. Firstly, CMC0 (intrinsic CMC, absent added salt) was coupled with quantitative structure - property relationship (QSPR) with defined by us parameter "CMC predictor" f1...
April 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28448604/non-invasive-imaging-assessment-of-the-biodistribution-of-gsk2849330-an-adcc-and-cdc-optimized-anti-her3-mab-and-its-role-in-tumor-macrophage-recruitment-in-human-tumor-bearing-mice
#5
Hasan Alsaid, Tinamarie Skedzielewski, Mary V Rambo, Kristen Hunsinger, Bao Hoang, William Fieles, Edward R Long, James Tunstead, Danielle J Vugts, Matthew Cleveland, Neil Clarke, Christopher Matheny, Beat M Jucker
The purpose of this work was to use various molecular imaging techniques to non-invasively assess GSK2849330 (anti HER3 ADCC and CDC enhanced 'AccretaMab' monoclonal antibody) pharmacokinetics and pharmacodynamics in human xenograft tumor-bearing mice. Immuno-PET biodistribution imaging of radiolabeled 89Zr-GSK2849330 was assessed in mice with HER3 negative (MIA-PaCa-2) and positive (CHL-1) human xenograft tumors. Dose dependency of GSK2849330 disposition was assessed using varying doses of unlabeled GSK2849330 co-injected with 89Zr-GSK2849330...
2017: PloS One
https://www.readbyqxmd.com/read/28448591/strain-based-diffusion-solver-for-realistic-representation-of-diffusion-front-in-physical-reactions
#6
Jong-Hyun Kim, Jung Lee
When simulating fluids, such as water or fire, interacting with solids, it is a challenging problem to represent details of diffusion front in physical reaction. Previous approaches commonly use isotropic or anisotropic diffusion to model the transport of a quantity through a medium or long interface. We have identified unrealistic monotonous patterns with previous approaches and therefore, propose to extend these approaches by integrating the deformation of the material with the diffusion process. Specifically, stretching deformation represented by strain is incorporated in a divergence-constrained diffusion model...
2017: PloS One
https://www.readbyqxmd.com/read/28448538/combined-lipidomic-and-proteomic-analysis-of-isolated-human-islets-exposed-to-palmitate-reveals-time-dependent-changes-in-insulin-secretion-and-lipid-metabolism
#7
Kirsten Roomp, Hjalti Kristinsson, Domitille Schvartz, Kumari Ubhayasekera, Ernest Sargsyan, Levon Manukyan, Azazul Chowdhury, Hannes Manell, Venkata Satagopam, Karlfried Groebe, Reinhard Schneider, Jonas Bergquist, Jean-Charles Sanchez, Peter Bergsten
Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion. In most in vitro models of T2DM, rodent islets or beta-cell lines are used and typically focus is on specific cellular pathways or organs. Our aim was to, firstly, develop a combined lipidomics and proteomics approach for lipotoxicity in isolated human islets and, secondly, investigate if the approach could delineate novel and/ or confirm reported mechanisms of lipotoxicity...
2017: PloS One
https://www.readbyqxmd.com/read/28448194/co-administration-of-an-excipient-oligonucleotide-helps-delineate-pathways-of-productive-and-nonproductive-uptake-of-phosphorothioate-antisense-oligonucleotides-in-the-liver
#8
Aaron J Donner, Edward V Wancewicz, Heather M Murray, Sarah Greenlee, Noah Post, Melanie Bell, Walt F Lima, Eric E Swayze, Punit P Seth
Phosphorothioate (PS) modified antisense oligonucleotides (ASOs) have progressed rapidly in the clinic for treating a variety of disease indications. We previously demonstrated that the activity of PS ASOs in the liver can be enhanced by co-infusion of an excipient oligonucleotide (EON). It was posited that the EON saturates a nonproductive uptake pathway(s) thereby permitting accumulation of the PS ASO in a productive tissue compartment. In this report, we measured PS ASO activity following administration by bolus, infusion or co-fusion with EON within hepatocytes and nonparenchymal cells (NPCs), of the liver...
April 27, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28448043/challenges-in-rheological-characterization-of-highly-concentrated-suspensions-a-case-study-for-screen-printing-silver-pastes
#9
Ceren Yüce, Norbert Willenbacher
A comprehensive rheological characterization of highly concentrated suspensions or pastes is mandatory for a targeted product development meeting the manifold requirements during processing and application of such complex fluids. In this investigation, measuring protocols for a conclusive assessment of different process relevant rheological parameters have been evaluated. This includes the determination of yield stress, viscosity, wall slip velocity, structural recovery after large deformation and elongation at break as well as tensile force during filament stretching...
April 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447930/a-novel-and-simple-method-for-tracheal-intubation-in-a-swine-model-preparing-for-the-era-of-xenotransplantation
#10
Hyub Huh, Hyong Hwan Lim, Ji Yeong Kim, Hye Won Shin, Hae Ja Lim, Suk Min Yoon, Seung Zhoo Yoon, Hye Won Lee
OBJECTIVES: Organ transplant in humans is an established therapy for a variety of end-stage organ diseases. However, due to organ shortages and lack of donors, the need for xenotransplant has gradually increased. Xenotransplantation has great potential to solve many of the problems facing organ transplantation. Pigs are being developed as xenogeneic organ donors for use in humans. In this study, we propose a novel and simple method for tracheal intubation in a swine model using neuromuscular blocking agents and laryngeal mask airway...
April 27, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28447883/c-h-infrared-absorption-and-solubility-of-ethylene-propyne-2-methyl-2-butene-and-2-methyl-1-3-butadiene-isoprene-in-liquid-argon-solutions
#11
Parashu R Nyaupane, Helena Diez-Y-Riega, Daniel Cordier, Carlos E Manzanares
The solubility of ethylene (H2C=CH2), propyne (CH3-C≡C-H), 2-methyl-2-butene (CH3-CH=C(CH3)2), and isoprene or 2-methyl-1, 3-butadiene (H2C=C(CH3)-CH=CH2) in liquid argon has been measured using mid-infrared and near-infrared (NIR) absorption. Spectra were recorded in the C-H infrared (IR) region. Spectra were obtained at increasing solution composition until the magnitude of the integrated absorption band reached a maximum value, indicating a saturated solution. The approximate experimental solubilities are: (600 ± 100) ppm at 92 K for ethylene, (22 ± 9) ppm at 100 K for propyne, (9 ± 5) ppm at 100 K for 2-methyl-2-butene, and (12 ± 2) ppm at 86 K for isoprene...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28447768/bio-inspired-bright-structurally-colored-colloidal-amorphous-array-enhanced-by-controlling-thickness-and-black-background
#12
Masanori Iwata, Midori Teshima, Takahiro Seki, Shinya Yoshioka, Yukikazu Takeoka
Inspired by Steller's jay, which displays angle-independent structural colors, angle-independent structurally colored materials are created, which are composed of amorphous arrays of submicrometer-sized fine spherical silica colloidal particles. When the colloidal amorphous arrays are thick, they do not appear colorful but almost white. However, the saturation of the structural color can be increased by (i) appropriately controlling the thickness of the array and (ii) placing the black background substrate...
April 26, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28447351/estimating-melanin-location-in-the-pigmented-skin-lesions-by-hue-saturation-lightness-color-space-values-of-dermoscopic-images
#13
REVIEW
Hiroshi Sakai, Yoshimi Ando, Kuniko Ikinaga, Masaru Tanaka
The depth of melanin in the skin can be estimated roughly by observation of the color exhibited on dermoscopy. Currently, there are no objective methods to estimate it. The aim of the present study was to clarify the relationship between the depth of melanin in the skin and the color variation exhibited, and to objectively estimate the 3-D location of melanin in the pigmented skin lesions from dermoscopic images. Representative colors in dermoscopic images of acral compound nevus, Spitz nevus and blue nevus were evaluated by the subjectively perceived color on dermoscopy and objective values in hue-saturation-lightness color space values...
May 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28447169/modeling-of-carbon-dioxide-mass-transfer-behavior-in-attached-cultivation-photobioreactor-using-the-analysis-of-the-ph-profiles
#14
Chunli Ji, Junfeng Wang, Runzhi Li, Tianzhong Liu
The CO2 mass transfer model associated with growth kinetics of microalgal biofilm in attached cultivation photobioreactor was developed and verified by using the analysis of pH profiles which were in equilibrium with inorganic carbon components concentrations (CO2, H2CO3, HCO3(-) and CO3(2-)) in medium. Model simulation results showed that the model well presented the biofilm growth process. The overall volumetric mass transfer coefficient of CO2 was more influenced by CO2 concentration in aerated gas but less by gas aeration rate and medium circulation rate...
April 26, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/28447094/%C3%AE-%C3%AE-functionalization-of-saturated-ketones-with-anthranils-via-cu-catalyzed-sequential-dehydrogenation-aza-michael-addition-annulation-cascade-reactions-in-one-pot
#15
Dipak Kumar Tiwari, Mandalaparthi Phanindrudu, Sandip Balasaheb Wakade, Jagadeesh Babu Nanubolu, Dharmendra Kumar Tiwari
An efficient method to access functionalized quinolines from the readily available saturated ketones and anthranils has been explored. This one-pot cascade reaction involves the in situ generation of α,β-unsaturated ketones by the copper catalysed dehydrogenation of saturated ketones followed by the aza-Michael addition of anthranils and subsequent annulation.
April 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28446905/okara-a-nutritionally-valuable-by-product-able-to-stabilize-lactobacillus-plantarum-during-freeze-drying-spray-drying-and-storage
#16
Gabriel Quintana, Esteban Gerbino, Andrea Gómez-Zavaglia
Okara is a nutritionally valuable by-product produced in large quantities as result of soymilk elaboration. This work proposes its use as both culture and dehydration medium during freeze-drying, spray-drying, and storage of Lactobacillus plantarum CIDCA 83114. Whole and defatted okara were employed as culture media for L. plantarum CIDCA 83114. The growth kinetics were followed by plate counting and compared with those of bacteria grown in MRS broth (control). No significant differences in plate counting were observed in the three media...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28446794/up-scalable-full-colour-plasmonic-pixels-with-controllable-hue-brightness-and-saturation
#17
Renilkumar Mudachathi, Takuo Tanaka
It has long been the interests of scientists to develop ink free colour printing technique using nano structured materials inspired by brilliant colours found in many creatures like butterflies and peacocks. Recently isolated metal nano structures exhibiting preferential light absorption and scattering have been explored as a promising candidate for this emerging field. Applying such structures in practical use, however, demands the production of individual colours with distinct reflective peaks, tunable across the visible wavelength region combined with controllable colour attributes and economically feasible fabrication...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446627/silicon-alleviates-nonalcoholic-steatohepatitis-by-reducing-apoptosis-in-aged-wistar-rats-fed-a-high-saturated-fat-high-cholesterol-diet
#18
Alba Garcimartín, M Elvira López-Oliva, Jorge A Sántos-López, Rosa A García-Fernández, Adrián Macho-González, Sara Bastida, Juana Benedí, Francisco J Sánchez-Muniz
Background: Lipoapoptosis has been identified as a key event in the progression of nonalcoholic fatty liver disease (NAFLD), and hence, antiapoptotic agents have been recommended as a possible effective treatment for nonalcoholic steatohepatitis (NASH). Silicon, included in meat as a functional ingredient, improves lipoprotein profiles and liver antioxidant defenses in aged rats fed a high-saturated fat, high-cholesterol diet (HSHCD). However, to our knowledge, the antiapoptotic effect of this potential functional meat on the liver has never been tested...
April 26, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28446622/cortical-venous-redness-represents-tissue-circulation-status-in-patients-with-moyamoya-disease
#19
Toshio Machida, Yoshinori Higuchi, Shigeki Nakano, Satoshi Ishige, Atsushi Fujikawa, Yuichi Akaogi, Junichiro Shimada, Yoichi Yoshida, Sigenori Maru, Junichi Ono
BACKGROUND AND PURPOSE: Venous oxygen saturation (SO2) is measured in medical fields to assess tissue circulation insufficiency. This study aimed to elucidate the use of a cortical venous redness measurement to evaluate hemodynamic changes during revascularization surgery for patients with moyamoya disease. METHODS: In this retrospective case-series analysis, we first quantitatively measured and correlated SO2 and R intensity of 24-bit color digital red-green-blue pictures of blood samples from 3 volunteers...
April 26, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28446501/dietary-long-chain-fatty-acids-and-carbohydrate-biomarker-evaluation-in-a-controlled-feeding-study-in-participants-from-the-women-s-health-initiative-cohort
#20
Xiaoling Song, Ying Huang, Marian L Neuhouser, Lesley F Tinker, Mara Z Vitolins, Ross L Prentice, Johanna W Lampe
Background: Biomarkers of macronutrient intake are lacking. Controlled human feeding studies that preserve the normal variation in nutrient and food consumption are necessary for the development and validation of robust nutritional biomarkers.Objective: We aimed to assess the utility of serum phospholipid fatty acids (PLFAs) as biomarkers of dietary intakes of fatty acids, total fat, and carbohydrate.Design: We used an individualized controlled feeding study in which 153 postmenopausal women from the Women's Health Initiative (WHI) were provided with a 2-wk controlled diet that mimicked each individual's habitual food intake...
April 26, 2017: American Journal of Clinical Nutrition
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