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https://www.readbyqxmd.com/read/29768555/the-relationship-between-atopy-and-neurological-manifestations-in-htlv-1-infection
#1
Raquel Crisóstomo Lima Verde, José Abraão Carneiro Neto, Silvane Maria Braga Santos, Edgar Marcelino Carvalho, Marcus Miranda Lessa
INTRODUCTION: Human T-cell lymphotropic virus type 1 (HTLV-1)induces exaggerated Th1 responses, whereas atopy is associated with exacerbated Th2 responses. METHODS: Here, a cross-sectional study compared the prevalence of atopy in HTLV-1 carriers and HAM/TSP patients. It also compared the spontaneous cytokine production in HTLV-1-infected individuals. A retrospective cohort study evaluated the development of neurological manifestations in atopic and non-atopic carriers...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29753900/dorsal-longitudinal-t-myelotomy-bischof-ii-technique-a-useful-antiquated-procedure-for-treatment-of-intractable-spastic-paraplegia
#2
Bunpot Sitthinamsuwan, Inthira Khampalikit, Luckchai Phonwijit, Akkapong Nitising, Sarun Nunta-Aree, Sirilak Suksompong
OBJECTIVE: Dorsal longitudinal T-myelotomy is a long-established operation to treat severe spastic paraplegia. The present study aimed to report this surgical technique and investigate the efficacy of T-myelotomy for spasticity relief. METHODS: All cases undergoing T-myelotomy for treatment of intractable spastic paraplegia during 2009-2017 were included. The spasticity severity was evaluated using the Modified Ashworth Scale (MAS), Penn Spasm Frequency Scale (PSFS), Adductor Tone Rating Scale (ATRS), degree of passive range of motion (PROM), and occurrence of abdominal muscle spasms...
May 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29731313/tophaceous-gout-causing-thoracic-spinal-cord-compression-case-report-and-review-of-the-literature
#3
REVIEW
Y Ding, W Wang, W Jiang, L Zhang, T Wang, Z Li
OBJECTIVE: To improve neurologists' awareness of spine gout by showing a rare case of tophaceous gout in thoracic spine and a summary of vertebral gout in order. MATERIAL AND METHODS: We reported a case of a 36-year-old male with a 2-year-history of hyperuricemia. Neurological examination suggested that the strength of his lower limbs decreased. Bilateral Babinski's sign and ankle clonus were positive. He had no bladder or bowel dysfunction. Computed tomography of the thoracic spine showed occupied lesions at the T9, T10 levels which led to the spinal stenosis...
May 3, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29664457/aspergillus-sinusitis-complicated-with-meningitis-and-multiple-cerebral-infarctions-in-immunocompetent-patient
#4
Ahmad AlHaj Houssen, Fahad Algreeshah
This is a case of a 33-year-old male complaining of severe headache, neck pain, photophobia, vomiting and high-grade fever of several days. He had history of nasal polyp removal and recurrent sinusitis in the last 8 years. On examination: conscious with glasco coma scale (GCS) 15/15 and normal limbs strength but with positive Babinski sign. For further observation, he was admitted and full work-up was done. Even though full empirical antibiotics were started, there was no immediate improvement and he deteriorated dramatically developing ocular deficit, hydrocephalus and lower level of consciousness with multiple infarctions found at different areas in brain...
April 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
https://www.readbyqxmd.com/read/29656001/-fl%C3%A3-neur-neurologique-in-paris-a-guide-to-pinpointing-the-houses-of-famous-neurologists-in-the-late-xix-century
#5
REVIEW
Hélio Afonso Ghizoni Teive, Francisco Manoel Branco Germiniani, Carlos Henrique Ferreira Camargo, Olivier Walusinski, Andrew J Lees
INTRODUCTION: During the last quarter of the XIX century, Paris, France, particularly the Salpêtrière Hospital was the most important centre of reference of Clinical Neurology in the world. The group based on the Salpêtrière Hospital, led by Professor Charcot, who was arguably the most celebrated neurologist in Europe. OBJECTIVE: In this historical review, we present and locate the addresses of the houses of these famous Parisian neurologists from the late XIX century...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29625795/the-venous-patterns-of-the-cubital-fossa-in-subjects-from-brazil
#6
L Pires, A L Ráfare, B U Peixoto, T O J S Pereira, D M M Pinheiro, M E B Siqueira, R D Vaqueiro, R C de Paula, M A Babinski, C A A Chagas
Venous punctures are among the most common procedures performed by healthcare professionals. In particular, the cubital fossa is the site where the venous accesses are frequently made due to the number of superficial veins and the numerous anastomoses in this region. The arrangement of these venous connections is of particular interest for clinical application in several areas, thus, the healthcare professional must possess knowledge about these vessels and their anatomical relationships. The present study aims to analyze the venous pattern of the cubital fossa among individuals from Brazil...
April 3, 2018: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/29540223/tongue-fasciculations-with-denervation-pattern-in-osmotic-demyelination-syndrome-a-case-report-of-diagnostic-dilemma
#7
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: The pathogenesis of osmotic demyelination syndrome is not completely understood and usually occurs with severe and prolonged hyponatremia, particularly with rapid correction. It can occur even in normonatremic patients, especially who have risk factors like alcoholism, malnutrition and liver disease. Bilateral tongue fasciculations with denervation pattern in electromyogram is a manifestation of damage to the hypoglossal nucleus or hypoglossal nerves. Tongue fasciculations were reported rarely in some cases of osmotic demyelination syndrome, but the exact mechanism is not explained...
March 14, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29529486/a-systematic-and-quantitative-evaluation-of-plantar-stimulation-the-effect-of-type-pattern-force-of-stimulation-in-eliciting-an-accurate-plantar-response
#8
Satish V Khadilkar, Akash H Chheda
OBJECTIVES: Systematic and quantitative evaluation of the plantar reflex has been infrequently studied in the past and can help assess the vexing variables encountered in its elicitation. The objective of this study was to determine the effect of type, pattern and force of stimulation in eliciting an accurate plantar response in patients with pyramidal dysfunction and healthy individuals. PATIENTS AND METHODS: A special instrument was designed to give a predesigned force of stimulus...
May 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29518832/-dars-mutations-responsible-for-hypomyelination-with-brain-stem-and-spinal-cord-involvement-and-leg-spasticity-report-of-two-cases-and-review-of-literature
#9
J Zhang, M Liu, L Zhou, Z B Zhang, J M Wang, Y W Jiang, Y Wu
Objective: To analyze the clinical and imaging features of hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL) due to mutations in DARS, and to identify DARS mutations responsible for HBSL. Methods: Data on 2 HBSL patients who were admitted to the pediatric department of Peking University First Hospital from January 2009 through December 2016 were reviewed and the 2 patients were followed up. Targeted next generation sequencing, whole exome sequencing and Sanger sequencing were employed to identify potential genetic variations of the children and their parents...
March 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29489680/miller-fisher-syndrome-complicated-by-bickerstaff-brainstem-encephalitis-a-case-report
#10
Chaoyang Jing, Zhuo Wang, Chaojia Chu, Ming Dong, Weihong Lin
RATIONALE: Bickerstaff brainstem encephalitis (BBE) and Miller-Fisher syndrome (MFS) might be a pedigree disease. Herein, we report a rare case that fits the diagnoses of both MFS and BBE. PATIENT CONCERNS: A 48-year-old woman was hospitalized due to blurred vision and unsteady gait lasting for 9 days, and numbness of the limbs lasting for 6 days. Physical examination showed restricted eye movement without nystagmus, bilateral flattening of forehead and nasolabial folds, and positive eyelash sign...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29484516/natural-history-of-neurological-abnormalities-in-cerebrotendinous-xanthomatosis
#11
Janice C Wong, Kailey Walsh, Douglas Hayden, Florian S Eichler
OBJECTIVES: Cerebrotendinous xanthomatosis (CTX) is a rare inherited neurodegenerative disorder in bile acid synthesis. The natural history of neurological abnormalities in CTX is not well understood. The object of this study was to determine neurological progression in CTX. METHODS: A literature search on PubMed for "cerebrotendinous xanthomatosis" yielded 91 publications that reported cases of CTX patients. Two independent reviewers abstracted information about the presence and age of onset of neurological abnormalities in published CTX cases...
February 26, 2018: Journal of Inherited Metabolic Disease
https://www.readbyqxmd.com/read/29468621/fusarium-brain-abscess-in-a-patient-with-diabetes-mellitus-and-liver-cirrhosis
#12
Yu-Ju Chen, Chao-Liang Chou, Kuan-Ju Lai, Ya-Ju Lin Lin
PURPOSE: Invasive mycosis caused by the Aspergillus, Fusarium, and Mucor can be fetal, especially in the immunocompromised patients with central nervous system (CNS) involvement. Here we present a case of CNS Fusarium infection, and this is the first reported case of Fusarium brain abscess in Taiwan. CASE REPORT: A 65-year-old woman presented with fever and conscious disturbance for 3 days. Neurological examination showed stupor consciousness, neck stiffness, multiple cranial nerves palsy, and bilateral Babinski signs...
September 15, 2017: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/29463778/a-calcium-sensing-receptor-mutation-causing-hypocalcemia-disrupts-a-transmembrane-salt-bridge-to-activate-%C3%AE-arrestin-biased-signaling
#13
Caroline M Gorvin, Valerie N Babinsky, Tomas Malinauskas, Peter H Nissen, Anders J Schou, Aylin C Hanyaloglu, Christian Siebold, E Yvonne Jones, Fadil M Hannan, Rajesh V Thakker
The calcium-sensing receptor (CaSR) is a G protein-coupled receptor (GPCR) that signals through Gq/11 and Gi/o to stimulate cytosolic calcium (Ca2+ i ) and mitogen-activated protein kinase (MAPK) signaling to control extracellular calcium homeostasis. Studies of loss- and gain-of-function CASR mutations, which cause familial hypocalciuric hypercalcemia type 1 (FHH1) and autosomal dominant hypocalcemia type 1 (ADH1), respectively, have revealed that the CaSR signals in a biased manner. Thus, some mutations associated with FHH1 lead to signaling predominantly through the MAPK pathway, whereas mutations associated with ADH1 preferentially enhance Ca2+ i responses...
February 20, 2018: Science Signaling
https://www.readbyqxmd.com/read/29345223/case-report-neurobrucellosis-with-plastered-spinal-arachnoiditis-a-magnetic-resonance-imaging-based-report
#14
Saraswati Nashi, Veeramani Preethish-Kumar, Sayani Maji, Nagarathna Chandrashekar, Kiran Polavarapu, Chetan Kashinkunti, Kajari Bhattacharya, Jitender Saini, Atchayaram Nalini
Diffuse spinal arachnoiditis in neurobrucellosis is a rare manifestation. We report a boy aged 17, presenting with hearing impairment and recurrent vomiting for 18 months, weight loss for 12 months, dysphagia, dysarthria, hypophonia for 6 months, and gait unsteadiness for 5 months. He had bilateral 5th (motor) to 12th cranial nerve palsy, wasting and weakness of limbs, fasciculations, absent tendon reflexes, and positive Babinski's sign. Cerebrospinal fluid (CSF) showed raised protein and pleocytosis. Magnetic resonance imaging (MRI) showed extensive enhancing exudates in cisterns and post-contrast enhancement of bilateral 5th, 6th, 7th, and 8th nerves...
January 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29340258/atypical-initial-presentation-of-painful-muscle-cramps-in-a-patient-with-amyotrophic-lateral-sclerosis-a-case-report-and-brief-review-of-the-literature
#15
Aaron R Kuzel, Muhammad Uzair Lodhi, Intekhab Askari Syed, Mustafa Rahim
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized clinically by progressive muscle weakness that can occur proximally or distally in either the upper or lower extremities. It includes both upper motor neuron signs (spasticity, hyperreflexia, clonus, and Babinski sign) and lower motor neuron signs (atrophy, weakness, and muscle fasciculation). Initial presentation of progressively painful muscle cramps should lead the physician to screen for other signs of amyotrophic lateral sclerosis...
November 10, 2017: Curēus
https://www.readbyqxmd.com/read/29274444/rare-giant-intradural-extramedullary-ependymoma
#16
Dengyong Liao, Jing Zhang, Haifeng Chen
A 23-year-old female was admitted to our hospital because she had suffered from back pain for 3 years and paralysis of both lower limbs for 10 days. Neurologic examination showed sensory disturbance and complete paralysis in bilateral lower extremities with negative Babinski sign. Contrast-enhanced magnetic resonance imaging showed there was an enhanced intradural lesion between T2 and T12, which pressed the spinal cord. The lesion was resected completely by laminectomy approach, and the tumor was totally intradural extramedullary...
March 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29260032/longitudinal-clinical-and-neuro-radiological-findings-in-a-patient-with-leukoencephalopathy-with-brain-calcifications-and-cysts-labrune-syndrome
#17
Yasushi Iwasaki, Ken-Ichiro Hoshino, Keiko Mori, Masumi Ito, Yoshinari Kawai, Maya Mimuro, Tamao Tsukie, Takeshi Ikeuchi, Mari Yoshida
Since she was 4 years old, the patient had exhibited frequent convulsive seizures, and she experienced severe headaches and depression in adulthood. At the age of 37 years, cerebral calcifications were detected, but she exhibited no cognitive or motor problems. She suffered a cerebral haemorrhage at 49 years old and experienced cognitive dysfunction, dysarthria, dysphagia, and left-hemiparesis as sequelae. After undergoing gastrostomy, she exhibited very slow cognitive deterioration associated with speech disturbance over more than 10 years...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29249373/idiopathic-cerebellar-ataxia-idca-diagnostic-criteria-and-clinical-analyses-of-63-japanese-patients
#18
Kunihiro Yoshida, Satoshi Kuwabara, Katsuya Nakamura, Ryuta Abe, Akira Matsushima, Minako Beppu, Yoshitaka Yamanaka, Yuji Takahashi, Hidenao Sasaki, Hidehiro Mizusawa
Cortical cerebellar atrophy (CCA) and multiple system atrophy with predominant cerebellar ataxia (MSA-C) are the two major forms of adult-onset sporadic ataxia. Contrary to MSA-C, there are neither diagnostic criteria nor neuroimaging features pathognomonic for CCA. Therefore, it is assumed that the category of CCA in the Japanese national registry include heterogeneous cerebellar ataxic disorders. To refine this category in more detail, we here used a clinical-based term, "idiopathic cerebellar ataxia (IDCA)", and proposed its diagnostic criteria...
January 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29187686/-portal-systemic-encephalopathy-with-bilateral-thalamic-and-internal-capsule-lesions-using-diffusion-weighted-mri-in-a-super-aged-patient
#19
Michiaki Matsuda, Shinpei Takesako, Mitsuhiro Nakazaki, Toru Nandate, Fujio Umehara
We describe the case of a 90-year-old woman who was hospitalized in July 2016 and subsequently experienced a sudden decline in consciousness level resulting in a state of deep coma. Involuntary movements were not observed, and bilateral Babinski signs were inconclusive. Diffusion-weighted MRI (DWI) of the brain showed bilateral hyperintensity in the thalamus and internal capsule, laboratory testing detected high levels of plasma ammonia, and an electroencephalogram showed delta waves and triphasic waves predominantly in the frontal lobe...
December 27, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/29174172/juvenile-onset-parkinsonism-with-pyramidal-signs-due-to-compound-heterozygous-mutations-in-the-f-box-only-protein-7-gene
#20
Lei Wei, Li Ding, Haiyan Li, Yinyao Lin, Yongqiang Dai, Xiaofeng Xu, Qing Dong, Yanjun Lin, Ling Long
BACKGROUND: Juvenile-onset parkinsonism is often caused by genetic factors. Mutations in several autosomal genes, including the F-box only protein 7 (FBXO7) gene, have been found in patients suffering from juvenile-onset parkinsonism with pyramidal signs. Only five types of FBXO7 mutations have been described. Here, we present a case report about a Chinese patient presenting with juvenile-onset parkinsonism likely caused by FBXO7 mutations. METHODS: The patient was a 32-year-old Chinese male...
February 2018: Parkinsonism & related Disorders
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