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https://www.readbyqxmd.com/read/27888997/comprehensive-assessment-of-myositis-specific-autoantibodies-in-polymyositis-dermatomyositis-associated-interstitial-lung-disease
#1
Hironao Hozumi, Tomoyuki Fujisawa, Ran Nakashima, Takeshi Johkoh, Hiromitsu Sumikawa, Akihiro Murakami, Noriyuki Enomoto, Naoki Inui, Yutaro Nakamura, Yuji Hosono, Yoshitaka Imura, Tsuneyo Mimori, Takafumi Suda
OBJECTIVES: Myositis-specific autoantibodies (MSAs) are associated with clinical phenotypes in polymyositis/dermatomyositis (PM/DM). No study has investigated the clinical features based on comprehensive MSA assessment in PM/DM-associated interstitial lung disease (ILD). We aimed to determine the practical significance of MSAs in PM/DM-ILD. METHODS: Sixty consecutive PM/DM-ILD patients were retrospectively analysed. Serum MSAs were comprehensively measured using immunoprecipitation assay...
December 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27851860/dermatopulmonary-syndrome-associated-with-anti-mda5-antibodies-after-allogeneic-hematopoietic-stem-cell-transplantation
#2
Clémence Lepelletier, Djaouida Bengoufa, Zeltni Lyes, Adèle de Masson, François Chasset, Marie Jachiet, David Michonneau, Marie Robin, Régis Peffault de Latour, Flore Sicre de Fontbrune, Yacine Tandjaoui-Lambiotte, Armand Bensussan, Michel Rybojad, Abdellatif Tazi, Martine Bagot, Gérard Socié, Anne Bergeron, Jean-David Bouaziz
Importance: Chronic graft-vs-host-disease (cGVHD) after allogeneic stem cell transplantation (AHSCT) may resemble autoimmune diseases. Anti-MDA5 (melanoma differentiation-associated gene 5) dermatopulmonary syndrome is a subset of dermatomyositis defined by specific clinical features and detection of anti-MDA5-antibodies in the serum. Objective: To characterize the clinical features of patients who underwent AHSCT and screened positively for anti-MDA5 antibodies...
November 16, 2016: JAMA Dermatology
https://www.readbyqxmd.com/read/27761751/myositis-specific-autoantibodies-and-their-association-with-malignancy-in-italian-patients-with-polymyositis-and-dermatomyositis
#3
Angela Ceribelli, Natasa Isailovic, Maria De Santis, Elena Generali, Micaela Fredi, Ilaria Cavazzana, Franco Franceschini, Luca Cantarini, Minoru Satoh, Carlo Selmi
This study aims to characterize myositis-specific antibodies in a well-defined cohort of patients with idiopathic inflammatory myopathy and to determine their association with cancer. Sera from 40 patients with polymyositis, dermatomyositis, and controls were tested by protein and RNA immunoprecipitation to detect autoantibodies, and immunoprecipitation-Western blot was used for anti-MJ/NXP-2, anti-MDA5, and anti-TIF1γ/α identification. Medical records were re-evaluated with specific focus on cancer. Anti-MJ/NXP-2 and anti-TIF1γ/α were the most common antibodies in dermatomyositis...
October 20, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27588444/clinical-analysis-and-outcome-of-interstitial-lung-disease-complicated-with-juvenile-dermatomyositis-and-juvenile-polymyositis
#4
Satoshi Sato, Yoji Uejima, Meika Nanbu, Eisuke Suganuma, Tadamasa Takano, Risa Tanaka, Tomoyuki Kabuki, Eiji Oguma, Tsutomu Oh-Ishi, Yutaka Kawano
OBJECTIVES: The aim of this study was to determine the clinical phenotype and outcome of interstitial lung disease (ILD) complicated with juvenile dermatomyositis (JDM) or juvenile polymyositis (JPM). METHODS: This was a single-center retrospective study. From 1984 to 2015, we retrospectively reviewed 29 patients who were diagnosed with JDM/JPM, among whom eight cases were ILD and 21 were non-ILD. The clinical features and laboratory findings included chest computed tomography (CT) images that were compared between the patients with ILD and non-ILD...
September 20, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27533321/recent-advances-in-dermatomyositis-specific-autoantibodies
#5
Manabu Fujimoto, Rei Watanabe, Yosuke Ishitsuka, Naoko Okiyama
PURPOSE OF REVIEW: In dermatomyositis, disease-specific autoantibodies now cover more than 70% of patients. These autoantibodies closely correlate with distinct clinical manifestations. In the past few years, extensive evidence has been accumulated on clinical significance of dermatomyositis-specific autoantibodies including autoantibodies against melanoma differentiation antigen 5 (MDA5), transcriptional intermediary factor 1 (TIF1), nuclear matrix protein 2 (NXP2), and small ubiquitin-like modifier activating enzyme (SAE)...
November 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/27523002/radiological-and-pathological-correlation-in-anti-mda5-antibody-positive-interstitial-lung-disease-rapidly-progressive-perilobular-opacities-and-diffuse-alveolar-damage
#6
Haruka Chino, Akimasa Sekine, Tomohisa Baba, Tae Iwasawa, Koji Okudela, Tamiko Takemura, Harumi Itoh, Shinji Sato, Yasuo Suzuki, Takashi Ogura
We herein present the first case of rapidly progressive interstitial lung disease (RP-ILD) with anti-melanoma differentiation-associated protein 5 (MDA5) antibody evaluated by surgical lung biopsy (SLB). High-resolution CT scan revealed perilobular opacities, which rapidly became thicker and formed consolidation, resulting in remarkable loss of lung volume. Specimens taken from SLB revealed membranous organization with alveolar occlusion, dilation of alveolar ducts, and sacs with collapsed alveoli, which are typical features of diffuse alveolar damage (DAD)...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27452897/anti-mda5-antibody-level-is-a-novel-tool-for-monitoring-disease-activity-in-rapidly-progressive-interstitial-lung-disease-with-dermatomyositis
#7
T Matsushita, K Mizumaki, M Kano, N Yagi, M Tennichi, A Takeuchi, Y Okamoto, Y O Hamaguchi, A Murakami, M Hasegawa, M Kuwana, M Fujimoto, K Takehara
BACKGROUND: Anti-MDA5 antibodies are associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). OBJECTIVE: We aimed to evaluate the relevance of monitoring anti-MDA5 antibody levels for the management of RP-ILD in patients with CADM or DM. METHODS: Twelve patients with CADM or DM (CADM, 10; DM, 2) accompanied by RP-ILD were included. Baseline characteristics and outcomes were recorded...
July 25, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27354955/lung-histopathological-pattern-in-a-survivor-with-rapidly-progressive-interstitial-lung-disease-and-anti-melanoma-differentiation-associated-gene-5-antibody-positive-clinically-amyopathic-dermatomyositis
#8
Atsushi Suzuki, Yasuhiro Kondoh, Hiroyuki Taniguchi, Kazuhiko Tabata, Tomoki Kimura, Kensuke Kataoka, Kenzo Ono, Mikiko Hashisako, Junya Fukuoka
Anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are specific indicators of patients with dermatomyositis, particularly clinically amyopathic dermatomyositis (CADM). CADM is occasionally accompanied by fatal, treatment-resistant, rapidly-progressive interstitial lung disease (RP-ILD). All previous reports showed that histopathological findings in RP-ILD with anti-MDA5 antibody-positive CADM indicated diffuse alveolar damage (DAD). This is the first report describing a non-DAD pattern in RP-ILD with anti-MDA5 antibody-positive CADM, which was improved by immunosuppressive therapy...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27252271/clinical-significance-and-new-detection-system-of-autoantibodies-in-myositis-with-interstitial-lung-disease
#9
R Nakashima, Y Hosono, T Mimori
Anti-aminoacyl-tRNA synthetase (ARS) and anti-melanoma differentiation-associated gene 5 (MDA5) antibodies are closely associated with interstitial lung disease in polymyositis and dermatomyositis. Anti-ARS-positive patients develop common clinical characteristics termed anti-synthetase syndrome and share a common clinical course, in which they respond well to initial treatment with glucocorticoids but in which disease tends to recur when glucocorticoids are tapered. Anti-MDA5 antibody is associated with rapidly progressive interstitial lung disease and poor prognosis, particularly in Asia...
July 2016: Lupus
https://www.readbyqxmd.com/read/27212600/reliability-and-clinical-utility-of-enzyme-linked-immunosorbent-assay-for-detection-of-anti-aminoacyl-trna-synthetase-antibody
#10
Takeo Abe, Shinichiro Tsunoda, Aki Nishioka, Kouta Azuma, Kazuyuki Tsuboi, Chie Ogita, Yuichi Yokoyama, Tetsuya Furukawa, Momo Maruoka, Masao Tamura, Takahiro Yoshikawa, Atsushi Saito, Masahiro Sekiguchi, Naoto Azuma, Masayasu Kitano, Kiyoshi Matsui, Yuji Hosono, Ran Nakashima, Koichiro Ohmura, Tsuneyo Mimori, Hajime Sano
  Anti-aminoacyl-tRNA synthetase (ARS) antibody is one of the myositis-specific autoantibodies to make a diagnosis of polymyositis (PM) and dermatomyositis (DM). Recently a new enzyme-linked immunosorbent assay (ELISA) kit of concurrently detected anti-ARS antibodies (anti-Jo-1, anti-PL-7, anti-PL-12, anti-EJ and anti-KS) have become to measure in the clinical setting. To evaluate the reliability of this ELISA kit, we measured anti-ARS antibodies in 75 PM and DM patients using by this ELISA assay and compared them with the results by RNA immunoprecipitation assay...
2016: Nihon Rinshō Men'eki Gakkai Kaishi, Japanese Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27171228/factors-associated-with-interstitial-lung-disease-in-patients-with-polymyositis-and-dermatomyositis-a-systematic-review-and-meta-analysis
#11
Li Zhang, Guoqin Wu, Di Gao, Guijian Liu, Lin Pan, Liyan Ni, Zheng Li, Qiang Wang
OBJECTIVES: Interstitial lung disease (ILD) is an extramuscular manifestation that results in increased morbidity and mortality from polymyositis (PM) and dermatomyositis (DM). The aim of this study was to systematically evaluate risk factors associated with the development of ILD in PM/DM. METHODS: Observational studies were identified from searching PubMed, Medline, Embase, and the Cochrane Library. Pooled odds ratios (ORs) or standardized mean differences (SMDs) and corresponding 95% confidence intervals (CIs) were obtained for the relationships between risk factors and ILD in PM/DM using either fixed- or random-effects models, whichever were appropriate...
2016: PloS One
https://www.readbyqxmd.com/read/27115353/clinical-utility-of-an-enzyme-linked-immunosorbent-assay-for-detecting-anti-melanoma-differentiation-associated-gene-5-autoantibodies
#12
Shinji Sato, Akihiro Murakami, Akiko Kuwajima, Kazuhiko Takehara, Tsuneyo Mimori, Atsushi Kawakami, Michiaki Mishima, Takafumi Suda, Mariko Seishima, Manabu Fujimoto, Masataka Kuwana
OBJECTIVE: Autoantibodies to melanoma differentiation-associated gene 5 (MDA5) are specifically expressed in patients with dermatomyositis (DM) and are associated with a subset of DM patients with rapidly progressive interstitial lung disease (RP-ILD). Here, we examined the clinical utility of a newly developed enzyme-linked immunosorbent assay (ELISA) system for detecting these antibodies. METHODS: Here we developed an improved ELISA for detecting anti-MDA5 antibodies...
2016: PloS One
https://www.readbyqxmd.com/read/27081322/biomarkers-and-autoantibodies-of-interstitial-lung-disease-with-idiopathic-inflammatory-myopathies
#13
REVIEW
Hajime Yoshifuji
Various autoantibodies are seen in idiopathic inflammatory myopathies. Among myositis-specific antibodies, anti-aminoacyl-tRNA synthetase and anti-melanoma differentiation-associated protein 5 (MDA5) antibodies are associated with interstitial lung disease (ILD). Anti-MDA5 antibodies are associated with dermatomyositis (DM) or clinically amyopathic DM complicated with rapidly progressive ILD. In anti-MDA5-positive patients, a random ground-glass attenuation pattern is a characteristic finding of ILD in chest high-resolution computed tomography...
2015: Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/26906088/testing-for-myositis-specific-autoantibodies-comparison-between-line-blot-and-immunoprecipitation-assays-in-57-myositis-sera
#14
Ilaria Cavazzana, Micaela Fredi, Angela Ceribelli, Cristina Mordenti, Fabio Ferrari, Nice Carabellese, Angela Tincani, Minoru Satoh, Franco Franceschini
OBJECTIVE: To analyze the performance of a line blot assay for the identification of autoantibodies in sera of patients affected by myositis, compared with immunoprecipitation (IP) as gold standard. METHODS: 66 sera of patients with myositis (23 polymyositis, 8 anti-synthetase syndromes, 29 dermatomyositis and 6 overlap syndromes) were tested by commercial LB (Euroimmun, Lubeck, Germany); 57 sera were analyzed also by IP of K562 cell extract radiolabeled with (35)S-methionine...
June 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/26806087/dermatomyositis-with-or-without-anti-melanoma-differentiation-associated-gene-5-antibodies-common-interferon-signature-but-distinct-nos2-expression
#15
Yves Allenbach, Gaëlle Leroux, Xavier Suárez-Calvet, Corinna Preusse, Eduard Gallardo, Baptiste Hervier, Aude Rigolet, Miguel Hie, Debora Pehl, Nicolas Limal, Peter Hufnagl, Norman Zerbe, Alain Meyer, Jessie Aouizerate, Yurdagul Uzunhan, Thierry Maisonobe, Hans-Hilmar Goebel, Olivier Benveniste, Werner Stenzel
The anti-melanoma differentiation-associated gene 5 (MDA5) autoantibody is specifically associated with dermatomyositis (DM). Nevertheless, anti-MDA5(+)-patients experience characteristic symptoms distinct from classic DM, including severe signs of extramuscular involvement; however, the clinical signs of myopathy are mild or even absent. The morphological and immunological features are not yet described in adulthood. Data concerning the pathophysiology of anti-MDA5 DM are sparse; however, the importance of the interferon (IFN) type I pathway involved in DM has been shown...
March 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/26739051/activation-of-rnase-l-by-murine-coronavirus-in-myeloid-cells-is-dependent-on-basal-oas-gene-expression-and-independent-of-virus-induced-interferon
#16
L Dillon Birdwell, Zachary B Zalinger, Yize Li, Patrick W Wright, Ruth Elliott, Kristine M Rose, Robert H Silverman, Susan R Weiss
UNLABELLED: The oligoadenylate synthetase (OAS)-RNase L pathway is a potent interferon (IFN)-induced antiviral activity. Upon sensing double-stranded RNA, OAS produces 2',5'-oligoadenylates (2-5A), which activate RNase L. Murine coronavirus (mouse hepatitis virus [MHV]) nonstructural protein 2 (ns2) is a 2',5'-phosphodiesterase (PDE) that cleaves 2-5A, thereby antagonizing RNase L activation. PDE activity is required for robust replication in myeloid cells, as a mutant of MHV (ns2(H126R)) encoding an inactive PDE fails to antagonize RNase L activation and replicates poorly in bone marrow-derived macrophages (BMM), while ns2(H126R) replicates to high titer in several types of nonmyeloid cells, as well as in IFN receptor-deficient (Ifnar1(-/-)) BMM...
January 6, 2016: Journal of Virology
https://www.readbyqxmd.com/read/26598044/-juvenile-dermatomyositis-and-new-autoantibodies-cases-and-review
#17
M Guarella, A-L Jurquet, K Retornaz, N Bardin, M-C Chastang, M Desjonquere, N Fabien, A Belot
Juvenile dermatomyositis (JDM) is the most common inflammatory myopathy in children. Its diagnosis is usually made on a clinical basis following the criteria of Bohan and Peter (1975). Recently, the presence of myositis-specific autoantibodies (MSAs) have started to be associated with specific outcome in adult patients; the diagnosis and prognosis value of these autoantibodies remains to be identified in children. We report four cases of JDM with MSAs focusing on clinical, biological, and radiological manifestations, and then we describe associated treatment...
December 2015: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/26597582/amelioration-of-japanese-encephalitis-by-blockage-of-4-1bb-signaling-is-coupled-to-divergent-enhancement-of-type-i-ii-ifn-responses-and-ly-6c-hi-monocyte-differentiation
#18
Seong Bum Kim, Jin Young Choi, Jin Hyoung Kim, Erdenebelig Uyangaa, Ajit Mahadev Patil, Sang-Youel Park, John Hwa Lee, Koanhoi Kim, Young Woo Han, Seong Kug Eo
BACKGROUND: Japanese encephalitis (JE), a neuroinflammation caused by zoonotic JE virus, is the major cause of viral encephalitis worldwide and poses an increasing threat to global health and welfare. To date, however, there has been no report describing the regulation of JE progression using immunomodulatory tools for developing therapeutic strategies. We tested whether blocking the 4-1BB signaling pathway would regulate JE progression using murine JE model. METHODS: Infected wild-type and 4-1BB-knockout (KO) mice were examined daily for mortality and clinical signs, and neuroinflammation in the CNS was evaluated by infiltration of inflammatory leukocytes and cytokine expression...
2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/26524895/-progress-of-autoantibody-examinations-for-connective-tissue-diseases
#19
REVIEW
Kengo Akashi, Jun Saegusa, Akio Morinobu
Connective tissue diseases are chronic inflammatory diseases that can affect multiple organs and, thus, have a broad spectrum of clinical presentations. Various autoantibodies are detected in patients with connective tissue diseases, represented by anti-nuclear antibody for systemic lupus erythematosus (SLE), systemic sclerosis (SSc), polymyositis/dermatomyositis (PM/DM), Sjögren's syndrome, and mixed connective tissue disease. Assessment of the autoantibody profile is fundamental for the clinical management of patients with connective tissue diseases, providing important data for the diagnosis, clinical characterization, and disease activity evaluation...
May 2015: Rinsho Byori. the Japanese Journal of Clinical Pathology
https://www.readbyqxmd.com/read/26457731/broad-spectrum-antibodies-against-self-antigens-and-cytokines-in-rag-deficiency
#20
Jolan E Walter, Lindsey B Rosen, Krisztian Csomos, Jacob M Rosenberg, Divij Mathew, Marton Keszei, Boglarka Ujhazi, Karin Chen, Yu Nee Lee, Irit Tirosh, Kerry Dobbs, Waleed Al-Herz, Morton J Cowan, Jennifer Puck, Jack J Bleesing, Michael S Grimley, Harry Malech, Suk See De Ravin, Andrew R Gennery, Roshini S Abraham, Avni Y Joshi, Thomas G Boyce, Manish J Butte, Kari C Nadeau, Imelda Balboni, Kathleen E Sullivan, Javeed Akhter, Mehdi Adeli, Reem A El-Feky, Dalia H El-Ghoneimy, Ghassan Dbaibo, Rima Wakim, Chiara Azzari, Paolo Palma, Caterina Cancrini, Kelly Capuder, Antonio Condino-Neto, Beatriz T Costa-Carvalho, Joao Bosco Oliveira, Chaim Roifman, David Buchbinder, Attila Kumanovics, Jose Luis Franco, Tim Niehues, Catharina Schuetz, Taco Kuijpers, Christina Yee, Janet Chou, Michel J Masaad, Raif Geha, Gulbu Uzel, Rebecca Gelman, Steven M Holland, Mike Recher, Paul J Utz, Sarah K Browne, Luigi D Notarangelo
Patients with mutations of the recombination-activating genes (RAG) present with diverse clinical phenotypes, including severe combined immune deficiency (SCID), autoimmunity, and inflammation. However, the incidence and extent of immune dysregulation in RAG-dependent immunodeficiency have not been studied in detail. Here, we have demonstrated that patients with hypomorphic RAG mutations, especially those with delayed-onset combined immune deficiency and granulomatous/autoimmune manifestations (CID-G/AI), produce a broad spectrum of autoantibodies...
November 2, 2015: Journal of Clinical Investigation
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