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https://www.readbyqxmd.com/read/28628588/youth-sports-and-physical-activity-innovative-perspectives-on-the-role-of-health-care-professionals
#1
John O Spengler, Angela D Smith, Jay E Maddock, Selina M Stasi
No abstract text is available yet for this article.
June 16, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28622409/ultrasound-guided-hydrodissection-decreases-gliding-resistance-of-the-median-nerve-within-the-carpal-tunnel
#2
Stefanie Evers, Andrew R Thoreson, Jay Smith, Chunfeng Zhao, Jennifer R Geske, Peter C Amadio
INTRODUCTION: The aim of this study was to assess alterations in median nerve biomechanics within the carpal tunnel resulting from ultrasound-guided hydrodissection in a cadaveric model. METHODS: Twelve fresh frozen human cadaver hands were used. Median nerve gliding resistance was measured at baseline and post-hydrodissection, by pulling the nerve proximally and then returning it to the origin. Six specimens were treated with hydrodissection, and 6 were used as controls...
June 16, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28618870/molecular-validation-of-chondrogenic-differentiation-and-hypoxia-responsiveness-of-platelet-lysate-expanded-adipose-tissue-derived-human-mesenchymal-stromal-cells
#3
Catalina Galeano-Garces, Emily T Camilleri, Scott M Riester, Amel Dudakovic, Dirk R Larson, Wenchun Qu, Jay Smith, Allan B Dietz, Hee-Jeong Im, Aaron J Krych, A Noelle Larson, Marcel Karperien, Andre J van Wijnen
OBJECTIVE: To determine the optimal environmental conditions for chondrogenic differentiation of human adipose tissue-derived mesenchymal stromal/stem cells (AMSCs). In this investigation we specifically investigate the role of oxygen tension and 3-dimensional (3D) culture systems. DESIGN: Both AMSCs and primary human chondrocytes were cultured for 21 days in chondrogenic media under normoxic (21% oxygen) or hypoxic (2% oxygen) conditions using 2 distinct 3D culture methods (high-density pellets and poly-ε-caprolactone [PCL] scaffolds)...
July 2017: Cartilage
https://www.readbyqxmd.com/read/28606814/does-cost-effectiveness-of-influenza-vaccine-choice-vary-across-the-u-s-an-agent-based-modeling-study
#4
Jay V DePasse, Mary Patricia Nowalk, Kenneth J Smith, Jonathan M Raviotta, Eunha Shim, Richard K Zimmerman, Shawn T Brown
BACKGROUND: In a prior agent-based modeling study, offering a choice of influenza vaccine type was shown to be cost-effective when the simulated population represented the large, Washington DC metropolitan area. This study calculated the public health impact and cost-effectiveness of the same four strategies: No Choice, Pediatric Choice, Adult Choice, or Choice for Both Age Groups in five United States (U.S.) counties selected to represent extremes in population age distribution. METHODS: The choice offered was either inactivated influenza vaccine delivered intramuscularly with a needle (IIV-IM) or an age-appropriate needle-sparing vaccine, specifically, the nasal spray (LAIV) or intradermal (IIV-ID) delivery system...
June 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28604139/major-bleeding-risk-and-healthcare-economic-outcomes-of-nonvalvular-atrial-fibrillation-patients-newly-initiated-with-oral-anticoagulant-therapy-in-the-real-world-setting
#5
Jay Lin, Jeffrey Trocio, Kiran Gupta, Jack Mardekian, Melissa Lingohr-Smith, Brandy Menges, Min You, Anagha Nadkarni
AIMS: This study compared the risk for major bleeding (MB) and healthcare economic outcomes of patients with nonvalvular atrial fibrillation (NVAF) after initiating treatment with apixaban versus rivaroxaban, dabigatran, or warfarin. METHODS: NVAF patients who initiated apixaban, rivaroxaban, dabigatran, or warfarin were identified from the IMS Pharmetrics Plus database (1/1/2013-9/30/2015). Propensity score matching (PSM) was used to balance differences in patient characteristics between study cohorts: patients treated with apixaban versus rivaroxaban, apixaban versus dabigatran, and apixaban versus warfarin...
June 10, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28594918/obesity-metabolic-factors-and-risk-of-different-histological-types-of-lung-cancer-a-mendelian-randomization-study
#6
Robert Carreras-Torres, Mattias Johansson, Philip C Haycock, Kaitlin H Wade, Caroline L Relton, Richard M Martin, George Davey Smith, Demetrius Albanes, Melinda C Aldrich, Angeline Andrew, Susanne M Arnold, Heike Bickeböller, Stig E Bojesen, Hans Brunnström, Jonas Manjer, Irene Brüske, Neil E Caporaso, Chu Chen, David C Christiani, W Jay Christian, Jennifer A Doherty, Eric J Duell, John K Field, Michael P A Davies, Michael W Marcus, Gary E Goodman, Kjell Grankvist, Aage Haugen, Yun-Chul Hong, Lambertus A Kiemeney, Erik H F M van der Heijden, Peter Kraft, Mikael B Johansson, Stephen Lam, Maria Teresa Landi, Philip Lazarus, Loïc Le Marchand, Geoffrey Liu, Olle Melander, Sungshim L Park, Gad Rennert, Angela Risch, Eric B Haura, Ghislaine Scelo, David Zaridze, Anush Mukeriya, Milan Savić, Jolanta Lissowska, Beata Swiatkowska, Vladimir Janout, Ivana Holcatova, Dana Mates, Matthew B Schabath, Hongbing Shen, Adonina Tardon, M Dawn Teare, Penella Woll, Ming-Sound Tsao, Xifeng Wu, Jian-Min Yuan, Rayjean J Hung, Christopher I Amos, James McKay, Paul Brennan
BACKGROUND: Assessing the relationship between lung cancer and metabolic conditions is challenging because of the confounding effect of tobacco. Mendelian randomization (MR), or the use of genetic instrumental variables to assess causality, may help to identify the metabolic drivers of lung cancer. METHODS AND FINDINGS: We identified genetic instruments for potential metabolic risk factors and evaluated these in relation to risk using 29,266 lung cancer cases (including 11,273 adenocarcinomas, 7,426 squamous cell and 2,664 small cell cases) and 56,450 controls...
2017: PloS One
https://www.readbyqxmd.com/read/28583819/transcranial-doppler-identification-of-neurologic-injury-during-pediatric-extracorporeal-membrane-oxygenation-therapy
#7
Jay F Rilinger, Craig M Smith, Raye Ann O deRegnier, Joshua L Goldstein, Michele G Mills, Marleta Reynolds, Carl L Backer, Delilah M Burrowes, Priya Mehta, Juan Piantino, Mark S Wainwright
BACKGROUND: We used transcranial Doppler to examine changes in cerebral blood flow velocity in children treated with extracorporeal membrane oxygenation. We examined the association between those changes and radiologic, electroencephalographic, and clinical evidence of neurologic injury. METHODS: This was a retrospective review and prospective observational study of patients 18 years old and younger at a single university children's hospital. Transcranial Doppler studies were obtained every other day during the first 7 days of extracorporeal membrane oxygenation, and 1 additional study following decannulation, in conjunction with serial neurologic examinations, brain imaging, and 6- to 12-month follow-up...
June 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28580260/posterolateral-rotatory-instability-of-the-elbow-part-ii-supplementary-examination-and-dynamic-imaging-techniques
#8
Christopher L Camp, Jay Smith, Shawn W O'Driscoll
Currently, a number of examination and imaging techniques exist for diagnosing posterolateral rotatory instability of the elbow. Although the posterolateral rotatory drawer is the primary examination maneuver, other special tests include the lateral pivot-shift test, prone push-up test, chair push-up test, and tabletop push-up test. In addition, posterolateral rotatory instability can be evaluated using radiography, magnetic resonance imaging, dynamic fluoroscopy, or dynamic ultrasound. In this Technical Note, each of these tests is described in detail...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28580259/posterolateral-rotatory-instability-of-the-elbow-part-i-mechanism-of-injury-and-the-posterolateral-rotatory-drawer-test
#9
Christopher L Camp, Jay Smith, Shawn W O'Driscoll
Posterolateral rotatory instability (PLRI) is the most commonly encountered pattern of elbow instability. It is the result of disruption of the lateral collateral ligament complex leading to a posterolateral rotatory subluxation of the ulna and radial head. A number of examination maneuvers have been described to assist in clinical identification of PLRI. Despite this, some inconsistency in the description of these techniques remains in the orthopaedic literature. This Technical Note details the mechanism of injury and patient presentation, and emphasizes the primacy of the posterolateral rotatory drawer test in the assessment of PLRI while providing video instruction on how it should be performed...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28559249/mk-8591-4-ethynyl-2-fluoro-2-deoxyadenosine-exhibits-potent-activity-against-hiv-2-isolates-and-drug-resistant-hiv-2-mutants-in-culture
#10
Vincent H Wu, Robert A Smith, Sara Masoum, Dana N Raugi, Selly Ba, Moussa Seydi, Jay A Grobler, Geoffrey S Gottlieb
There is a pressing need to identify more effective antiretroviral drugs for HIV-2 treatment. Here, we show the investigational compound MK-8591 (4' -ethynyl-2-fluoro-2' -deoxyadenosine; EFdA) is highly active against group A and B isolates of HIV-2; 50% effective concentrations [EC50] for HIV-2 were, on average, 4.8-fold lower than those observed for HIV-1. MK-8591 also retains potent activity against multinucleoside-resistant HIV-2 mutants (EC50 ≤11 nM). These data suggest that MK-8591 may have antiviral activity in HIV-2-infected individuals...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28535119/comparison-of-effectiveness-and-safety-of-treatment-with-apixaban-vs-other-oral-anticoagulants-among-elderly-nonvalvular-atrial-fibrillation-patients
#11
Steven Deitelzweig, Xuemei Luo, Kiran Gupta, Jeffrey Trocio, Jack Mardekian, Tammy Curtice, Melissa Lingohr-Smith, Brandy Menges, Jay Lin
OBJECTIVE: To compare the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) of elderly (≥65 years of age) nonvalvular atrial fibrillation (NVAF) patients initiating apixaban vs. rivaroxaban, dabigatran, or warfarin. METHODS: NVAF patients with Medicare Advantage coverage in the US initiating oral anticoagulants (OACs, index event) were identified from the Humana database (1/1/2013-9/30/2015) and grouped into cohorts depending on OAC initiated. Propensity score matching (PSM), 1:1, was conducted among patients treated with apixaban vs...
May 23, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28526500/pulmonary-function-tests-do-not-predict-mortality-in-patients-undergoing-continuous-flow-left-ventricular-assist-device-implantation
#12
Edo K S Bedzra, Todd F Dardas, Richard K Cheng, Jay D Pal, Claudius Mahr, Jason W Smith, Kent Shively, S Carolina Masri, Wayne C Levy, Nahush A Mokadam
OBJECTIVES: To investigate the effect of pulmonary function testing on outcomes after continuous flow left ventricular assist device implantation. METHODS: A total of 263 and 239 patients, respectively, had tests of forced expiratory volume in 1 second and diffusing capacity of the lungs for carbon monoxide preoperatively for left ventricular assist device implantations between July 2005 and September 2015. Kaplan-Meier analysis and multivariable Cox regressions were performed to evaluate mortality...
April 11, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28495242/the-association-between-the-hospital-consumer-assessment-of-healthcare-providers-and-systems-hcahps-survey-and-real-world-clinical-outcomes-in-lumbar-spine-surgery
#13
Jay M Levin, Robert D Winkelman, Gabriel A Smith, Joseph Tanenbaum, Edward C Benzel, Thomas E Mroz, Michael P Steinmetz
BACKGROUND CONTEXT: The patient experience of care as measured by the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) survey is currently used to determine hospital reimbursement. The current literature inconsistently demonstrates an association between patient satisfaction and surgical outcomes. PURPOSE: To determine whether patient satisfaction with hospital experience is associated with better clinical outcomes in lumbar spine surgery...
May 8, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28483151/postoperative-swallowing-assessment-after-lung-transplantation
#14
Brooke Baumann, Sara Byers, Tamara Wasserman-Wincko, Libby Smith, Bridget Hathaway, Jay Bhama, Norihisa Shigemura, J W Awori Hayanga, Jonathan D'Cunha, Jonas T Johnson
BACKGROUND: Dysphagia, aspiration, and potential pneumonia represent a major source of morbidity in patients undergoing lung transplantation. Conditions that potentiate dysphagia and aspiration include frailty and prolonged intubation. Our group of speech-language pathologists has been actively involved in performance of a bedside evaluation of swallowing, and instrumental evaluation of swallowing with modified barium swallow, and postoperative management in patients undergoing lung transplantation...
July 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28482717/radiation-therapy-improves-survival-in-patients-with-testicular-diffuse-large-b-cell-lymphoma
#15
Jennifer C Ho, Bouthaina S Dabaja, Sarah A Milgrom, Grace L Smith, Jay P Reddy, Ali Mazloom, Ken H Young, Lijuan Deng, L Jeffrey Medeiros, Wenli Dong, Pamela K Allen, Therese Y Andraos, Nathan H Fowler, Loretta J Nastoupil, Yasuhiro Oki, Luis E Fayad, Francesco Turturro, Sattva S Neelapu, Jason Westin, Fredrick B Hagemeister, Maria Alma Rodriguez, Chelsea C Pinnix
In 120 Stage I-IV testicular diffuse large B-cell lymphoma (DLBCL) patients treated from 1964 to 2015, we assessed the benefits of prophylactic contralateral testicular radiation (RT) and prophylactic central nervous system (CNS) therapy on overall, progression free, testicular relapse free, and CNS relapse free survival (OS, PFS, TRFS, and CRFS, respectively). Seventy percent of patients received RT, 53% received anthracyclines and rituximab (modern therapy), and 61% received CNS prophylaxis. On univariate analysis RT was associated with improved TRFS, PFS, and trended toward improved OS...
May 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28472714/the-association-between-socioeconomic-status-and-adult-fast-food-consumption-in-the-u-s
#16
Jay L Zagorsky, Patricia K Smith
Health follows a socioeconomic status (SES) gradient in developed countries, with disease prevalence falling as SES rises. This pattern is partially attributed to differences in nutritional intake, with the poor eating the least healthy diets. This paper examines whether there is an SES gradient in one specific aspect of nutrition: fast-food consumption. Fast food is generally high in calories and low in nutrients. We use data from the 2008, 2010, and 2012 waves of the National Longitudinal Survey of Youth (NLSY79) to test whether adult fast-food consumption in the United States falls as monetary resources rise (n=8136)...
April 19, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/28472652/de-novo-coding-variants-are-strongly-associated-with-tourette-disorder
#17
A Jeremy Willsey, Thomas V Fernandez, Dongmei Yu, Robert A King, Andrea Dietrich, Jinchuan Xing, Stephan J Sanders, Jeffrey D Mandell, Alden Y Huang, Petra Richer, Louw Smith, Shan Dong, Kaitlin E Samocha, Benjamin M Neale, Giovanni Coppola, Carol A Mathews, Jay A Tischfield, Jeremiah M Scharf, Matthew W State, Gary A Heiman
Whole-exome sequencing (WES) and de novo variant detection have proven a powerful approach to gene discovery in complex neurodevelopmental disorders. We have completed WES of 325 Tourette disorder trios from the Tourette International Collaborative Genetics cohort and a replication sample of 186 trios from the Tourette Syndrome Association International Consortium on Genetics (511 total). We observe strong and consistent evidence for the contribution of de novo likely gene-disrupting (LGD) variants (rate ratio [RR] 2...
May 3, 2017: Neuron
https://www.readbyqxmd.com/read/28449921/seroconversion-rate-among-health-care-workers-exposed-to-hiv-contaminated-body-fluids-the-university-of-pittsburgh-13-year-experience
#18
Chibueze A Nwaiwu, Francesco M Egro, Saundra Smith, Jay D Harper, Alexander M Spiess
BACKGROUND: The studies enumerating the risk of HIV transmission to health care workers (HCWs) as 0.3% after percutaneous exposure to HIV-positive blood, and 0.09% after a mucous membrane exposure, are weakened by dated literature. Our study aims to demonstrate the seroconversion rate after exposure to HIV-contaminated body fluids in a major academic center in the United States. METHODS: A prospectively maintained database of reported occupational injuries occurring between 2002 and 2015 at an academic medical center was analyzed...
April 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28449917/seroconversion-rates-among-health-care-workers-exposed-to-hepatitis-c-virus-contaminated-body-fluids-the-university-of-pittsburgh-13-year-experience
#19
Francesco M Egro, Chibueze A Nwaiwu, Saundra Smith, Jay D Harper, Alexander M Spiess
BACKGROUND: Hepatitis C virus (HCV) transmission to health care personnel (HCP) after exposure to a HCV-positive source has been reported to occur at an average rate of 1.8% (range, 0%-10%). We aimed to determine the seroconversion rate after exposure to HCV-contaminated body fluid in a major U.S. academic medical center. METHODS: A longitudinal analysis of a prospectively maintained database of reported occupational injuries occurring between 2002 and 2015 at the University of Pittsburgh Medical Center was performed...
April 24, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28431811/potential-consequences-of-not-using-live-attenuated-influenza-vaccine
#20
Kenneth J Smith, Mary Patricia Nowalk, Angela Wateska, Shawn T Brown, Jay V DePasse, Jonathan M Raviotta, Eunha Shim, Richard K Zimmerman
INTRODUCTION: Decreased live attenuated influenza vaccine (LAIV) effectiveness in the U.S. prompted the Advisory Committee on Immunization Practices in August 2016 to recommend against this vaccine's use. However, overall influenza uptake increases when LAIV is available and, unlike the U.S., LAIV has retained its effectiveness in other countries. These opposing countercurrents create a dilemma. METHODS: To examine the potential consequences of the decision to not recommend LAIV, which may result in decreased influenza vaccination coverage in the U...
April 18, 2017: American Journal of Preventive Medicine
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