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https://www.readbyqxmd.com/read/29913291/suprasellar-germinomas-two-case-reports-and-literature-review
#1
Paulo Moacir Mesquita Filho, Fabio Pires Santos, Luiza Rech Köhler, Gregori Manfroi, Fernanda De Carli, Moises Augusto de Araujo, Daniela Schwingel
No abstract text is available yet for this article.
June 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29896137/neuropsychological-consequences-for-survivors-of-childhood-brain-tumor-in-malaysia
#2
Hamidah Alias, Sie Chong D Lau, Ilse Schuitema, Leo M J de Sonneville
Objective: This study aimed to evaluate neuropsychological consequences in survivors of childhood brain tumor. Method: A case-control study was conducted over a period of 4 months in a tertiary referral center in Kuala Lumpur, Malaysia. Fourteen survivors of childhood brain tumor aged 7-18 years, who were off-treatment for at least 1 year and were in remission, and 31 unrelated healthy controls were recruited. The median age at diagnosis was 8.20 years (range: 0.92-12.96 years). The diagnoses of brain tumors were medulloblastoma, germ cell tumor, pineocytoma, pilocystic astrocytoma, suprasellar germinoma, and ependymoma...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29895434/-thickening-of-the-pituitary-stalk-in-children-and-adolescents-with-central-diabetes-insipidus-causes-and-consequences
#3
Beatriz Corredor Andrés, María Teresa Muñoz Calvo, Miguel Ángel López Pino, María Márquez Rivera, Lourdes Travieso Suárez, Jesús Pozo Román, Jesús Argente
BACKGROUND: Central diabetes insipidus (CDI) is a rare disorder in children. The aetiology of CDI in childhood is heterogeneous. The aim of this study is to illustrate the importance of a careful clinical and neuro-radiological follow-up of the pituitary and hypothalamus region in order to identify the aetiology and the development of associated hormonal deficiencies. METHODS: Clinical and auxological variables of 15 children diagnosed with CDI were retrospectively analysed in a paediatric hospital...
June 9, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29848146/central-nervous-system-germ-cell-tumors-a-review-of-the-literature
#4
Ziren Kong, Yaning Wang, Congxin Dai, Yong Yao, Wenbin Ma, Yu Wang
Central nervous system germ cell tumors are rare intracranial tumors that mainly occur in pediatrics with substantial variation in the incidence among different regions and genders. Histologically, central nervous system germ cell tumors can be divided into germinomas and nongerminomatous germ cell tumors. The molecular pathology of central nervous system germ cell tumors, particularly germinomas, is mainly based on the presence of isochromosome 12p, gain-of-function of the KIT gene, and a globally low DNA methylation profile...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29794314/-a-case-of-ventriculoperitoneal-shunt-dysfunction-in-an-adult-secondary-to-constipation
#5
Lisa Nakamura, Ryuta Saito, Masayuki Kanamori, Takahiro Morita, Ryosuke Tashiro, Teiji Tominaga
INTRODUCTION: Ventriculoperitoneal(VP)shunts function because of the pressure differential between the intracranial space and the peritoneal cavity. Although chronic constipation is often a cause of VP shunt dysfunction in children, it is not well recognized in adults. We present a case of shunt dysfunction that not only resolved after resolution of constipation but also resulted in overdrainage. CASE REPORT: A 28-year-old woman who had a VP shunt placed 11 years prior for hydrocephalus was referred to our department because of an enlarged ventricle diagnosed with computed tomography(CT)...
May 2018: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29780941/unilateral-paraneoplastic-optic-disc-edema-and-retinal-periphlebitis-in-pineal-germinoma
#6
Gunay Uludag, Aslihan Onay, Sumru Onal
Purpose: To describe a unilateral ocular paraneoplastic syndrome in pineal germinoma. Observations: A 24-year-old male presented with diplopia, excessive thirst, and frequent urination. Cranial MRI showed a mass in pineal gland. Dorsal midbrain syndrome signs were present. Examination showed optic disc edema and segmental retinal periphlebitis in right and normal fundus in left eye. Rheumatologic work-up was negative. Brain biopsy confirmed pineal germinoma. Retinal findings were attributed to paraneoplastic syndrome...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29742886/intracranial-germ-cell-tumor-in-the-molecular-era
#7
REVIEW
Ji Hoon Phi, Kyu-Chang Wang, Seung-Ki Kim
Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection to one sex, and geographic difference in incidence all present enigmas and fascinating challenges. The treatment of iGCT has advanced for germinoma to date; thus, clinical attention has shifted from survival to long-term quality of life. However, for non-germinomatous GCT, current protocols provide only modest improvement and more innovative therapies are needed...
May 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29693779/high-dose-chemotherapy-with-autologous-stem-cell-transplantation-spares-re-irradiation-for-recurrent-intracranial-germinoma
#8
Hirohito Kubota, Katsutsugu Umeda, Kouzuki Kagehiro, Kuniaki Tanaka, Tomoo Daifu, Takayuki Hamabata, Seishiro Nodomi, Itaru Kato, Hidefumi Hiramatsu, Yoshiki Arakawa, Takashi Mizowaki, Souichi Adachi
The clinical outcome of high-dose chemotherapy (HDC) with autologous stem cell transplantation was retrospectively analyzed in six patients with recurrent intracranial germinoma. Prior to HDC, all patients achieved complete remission after platinum and ifosfamide-based chemotherapy. A melphalan-based conditioning regimen was administered in either a single cycle or multiple sequential cycles. Five of the six patients are alive and free from disease, with a median survival of 65 months, among which four patients avoided re-irradiation...
April 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29682070/capsuloganglionic-germinoma-a-rare-site-for-uncommon-childhood-tumor
#9
Kuntal Kanti Das, Jeena Joseph, Amit Kumar Singh, Pradeep Sharma, Jayesh Sardhara, Kamlesh Singh Bhaisora, Anant Mehrotra, Arun Kumar Srivastava, Sushila Jaiswal, Rabi Narayan Sahu, Awadhesh Kumar Jaiswal, Sanjay Behari
Germ cell tumors (GCTs) are rare intracranial tumors with a strong predilection for children. Commonly, these tumors arise either in the suprasellar or the pineal region. The basal ganglia-thalamus complex represents a rare site of nonmidline intracranial GCTs. Such basal ganglionic GCTs have been reported to produce certain interesting clinico-radiological features, the knowledge of which may provide important diagnostic clues preoperatively. We present the case of a 9.5-year-old boy who presented with right hemiparesis and precocious puberty...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29682040/widespread-intra-abdominal-carcinomatosis-from-a-rhabdoid-meningioma-after-placement-of-a-ventriculoperitoneal-shunt-a-case-report-and-review-of-the-literature
#10
Jun Jie Ng, Kok Ann Teo, Asim Shabbir, Tseng Tsai Yeo
Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors through ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). However, there has been no previous reports in literature involving meningiomas. A case of primary rhabdoid meningioma with widespread intra-abdominal carcinomatosis after placement of a VPS in a 36-year-old man is described. The patient underwent preoperative angioembolization of the tumor, craniotomy, and surgical excision, followed by postoperative gamma knife radiosurgery...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29617441/pd-1-pd-l1-expression-in-a-series-of-intracranial-germinoma-and-its-association-with-foxp3-and-cd8-infiltrating-lymphocytes
#11
Bin Liu, Yoshiki Arakawa, Ryuta Yokogawa, Shinya Tokunaga, Yukinori Terada, Daiki Murata, Yasuzumi Matsui, Ko-Ichi Fujimoto, Nobuyuki Fukui, Masahiro Tanji, Yohei Mineharu, Sachiko Minamiguchi, Susumu Miyamoto
One histopathological characteristic of intracranial germinoma is abundant tumor-infiltrating lymphocytes (TILs) showing a two-cell pattern with large undifferentiated tumor cells. The programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L) axis has recently been recognized as an anti-tumor immune system. To evaluate intratumor immune status in intracranial germinoma, we examined expressions of PD-1 and PD-L1 (clone 28-8) and subtypes of TILs. Expressions of PD-1 and PD-L1 were detected immunohistochemically in 25 formalin-fixed, paraffin-embedded tumor specimens from 24 patients with intracranial germinoma consisting of 22 primary and 3 recurrent tumors...
2018: PloS One
https://www.readbyqxmd.com/read/29582270/indications-for-salvage-surgery-during-treatment-for-intracranial-germ-cell-tumors
#12
Masayuki Kanamori, Toshihiro Kumabe, Mika Watanabe, Masashi Chonan, Ryuta Saito, Yoji Yamashita, Yoshikazu Ogawa, Yukihiko Sonoda, Teiji Tominaga
This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuvant treatment before salvage surgery into increase (growing group, five cases), no change (stable group, seven cases), and decrease (shrinkage group, eight cases) in tumor size. Changes in tumor markers, histological findings, and the pattern of failure after salvage surgery were reviewed...
March 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29581022/neuro-endoscopic-cylinder-surgery-and-5-aminolevulinic-acid-5-ala-photodynamic-diagnosis-of-deep-seated-intracranial-lesions
#13
Jungsu Choo, Kazuhito Takeuchi, Yuichi Nagata, Fumiharu Ohka, Yugo Kishida, Tadashi Watanabe, Yusuke Satoh, Tetsuya Nagatani, Kyozo Kato, Toshihiko Wakabayashi, Atsushi Natsume
BACKGROUND: Microscopic detection of intracranial brain tumors with 5-aminolevulinic acid (5-ALA) has proven extremely useful, and reports the use of 5-ALA have recently increased. However, few reports have described 5-ALA photodynamic diagnosis (PDD) using a neuro-endoscope. We performed neuro-endoscopic 5-ALA PDD for various brain lesions and present a procedure using only a neuro-endoscope. METHODS: We describe the diagnosis of 20 intracranial brain lesion cases with a 5-ALA-guided fluorescence endoscope...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29552538/granulomatous-response-in-intracranial-germinomas-diagnostic-problems
#14
Sree Rekha Jinkala, Elancheran Muthalagan, Bhawana Ashok Badhe
Intracranial germinomas are rare and account for <0.5% of primary intracranial tumors. In contrast to the gonadal germinomas, these do not show granulomatous response within the tumor. In rare cases, the granulomatous component may obscure the tumor proper and lead to diagnostic difficulties/dilemmas. We report a case of suprasellar germinoma in a 17-year-old boy which showed granulomatous response. We discuss the differentials to be considered in such a scenario and discuss the utility of squash cytology and immunohistochemistry in these lesions...
January 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29492156/widespread-intra-abdominal-carcinomatosis-from-a-rhabdoid-meningioma-after-placement-of-a-ventriculoperitoneal-shunt-a-case-report-and-review-of-the-literature
#15
N G Jun Jie, Kok Ann Teo, Asim Shabbir, Tseng Tsai Yeo
Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors via ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). However, there has been no previous report in the literature involving meningiomas. A case of primary rhabdoid meningioma with widespread intra-abdominal carcinomatosis after placement of a VPS in a 36-year-old man is described. The patient underwent preoperative angioembolization of the tumor, craniotomy, and surgical excision, followed by postoperative gamma knife radiosurgery...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29487768/suprasellar-germinoma-presenting-with-slipped-capital-femoral-epiphysis-case-report
#16
Keerthana Sankar, Wade Kyono, Corey Raffel, Theodore Nicolaides
Slipped capital femoral epiphysis (SCFE) is a fracture that results from displacement of the proximal femoral epiphysis from the femoral neck. SCFE can be caused by various endocrinopathies that lead to bone weakening in both adult and pediatric patients. We report a rare case of suprasellar germinoma presenting with SCFE in an 11-year-old female patient. The findings of this case further support the need to consider pituitary lesions as the underlying cause of endocrine deficiences leading to SCFE.
December 16, 2017: Curēus
https://www.readbyqxmd.com/read/29454505/current-management-of-intracranial-germ-cell-tumours
#17
A Bowzyk Al-Naeeb, M Murray, G Horan, F Harris, R-D Kortmann, J Nicholson, T Ajithkumar
Intracranial germ cell tumours (icGCTs) are uncommon tumours occurring in children and young adults. They are usually segregated into germinomas and non-germinomatous tumours (NGGCTs) in most classifications. Germinomas are highly curable tumours with multimodality treatment, but NGGCTs are associated with poorer survival outcomes. There are some differences in the approach to the management of icGCTs globally. Current research generally focuses on reducing treatment intensity, particularly the dose and volume of radiotherapy, in order to minimise the risks of late sequelae while maintaining high cure rates in icGCTs...
April 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29415126/central-nervous-system-germinomas-express-programmed-death-ligand-1
#18
Miriam E Wildeman, Matthew J Shepard, Edward H Oldfield, M Beatriz S Lopes
Immunomodulation and tumor-induced tolerance is one of the central mechanisms in the oncogenesis of malignant and benign neoplasms. While numerous pathways have been described, signaling through the programmed death receptor 1 (PD-1) on T lymphocytes, via activation through its ligand, programmed death ligand 1 (PD-L1) expressed on tumor cells is one of the central pathways involved in tumor-induced tolerance. While the neoplastic component of germinomas of the CNS is the germ cell, these tumors also exhibit an abundance of quiescent tumor-infiltrating lymphocytes...
April 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29378909/intracranial-germinoma-causing-cerebral-haemiatrophy-and-hypopituitarism
#19
Bruno Fukelmann Guedes, Marcio Nattan Portes Souza, Breno José Alencar Pires Barbosa, Fernando Pereira Frassetto, Leandro Tavares Lucato, Carla Rachel Ono, Luiz Henrique Martins Castro, Ricardo Nitrini, Mateus Mistieri Simabukuro
A young woman presented with primary amenorrhoea, progressive haemiparesis, visual disturbance, dementia and focal motor seizures. Investigations showed hypopituitarism, unilateral cerebral atrophy and inflamed cerebrospinal fluid. A trans-sphenoidal biopsy gave a unifying diagnosis of a pituitary germinoma.
January 29, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29335082/-a-comparative-analysis-of-anti-n-methyl-d-aspartate-receptor-encephalitis-with-or-without-abnormal-findings-on-cranial-magnetic-resonance-imaging
#20
COMPARATIVE STUDY
Jian-Zhao Zhang, Qian Chen, Ping Zheng, Li-Na Xie, Xiao-Li Yi, Hai-Tao Ren, Jian Yang
OBJECTIVE: To investigate the clinical features of children with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis with normal or abnormal cranial magnetic resonance imaging (MRI) findings via a comparative analysis. METHODS: A retrospective analysis was performed for the clinical data of 33 children with anti-NMDAR encephalitis. The clinical features and prognosis were compared between the children with normal and abnormal cranial MRI findings. RESULTS: In the 33 children with anti-NMDAR encephalitis, the most common initial symptoms were seizures (61%) and involuntary movement (61%), followed by language disorder (54%), mental and behavioral abnormalities (52%), and disturbance of consciousness (30%)...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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