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https://www.readbyqxmd.com/read/29617441/pd-1-pd-l1-expression-in-a-series-of-intracranial-germinoma-and-its-association-with-foxp3-and-cd8-infiltrating-lymphocytes
#1
Bin Liu, Yoshiki Arakawa, Ryuta Yokogawa, Shinya Tokunaga, Yukinori Terada, Daiki Murata, Yasuzumi Matsui, Ko-Ichi Fujimoto, Nobuyuki Fukui, Masahiro Tanji, Yohei Mineharu, Sachiko Minamiguchi, Susumu Miyamoto
One histopathological characteristic of intracranial germinoma is abundant tumor-infiltrating lymphocytes (TILs) showing a two-cell pattern with large undifferentiated tumor cells. The programmed cell death 1 (PD-1)/programmed cell death 1 ligand (PD-L) axis has recently been recognized as an anti-tumor immune system. To evaluate intratumor immune status in intracranial germinoma, we examined expressions of PD-1 and PD-L1 (clone 28-8) and subtypes of TILs. Expressions of PD-1 and PD-L1 were detected immunohistochemically in 25 formalin-fixed, paraffin-embedded tumor specimens from 24 patients with intracranial germinoma consisting of 22 primary and 3 recurrent tumors...
2018: PloS One
https://www.readbyqxmd.com/read/29582270/indications-for-salvage-surgery-during-treatment-for-intracranial-germ-cell-tumors
#2
Masayuki Kanamori, Toshihiro Kumabe, Mika Watanabe, Masashi Chonan, Ryuta Saito, Yoji Yamashita, Yoshikazu Ogawa, Yukihiko Sonoda, Teiji Tominaga
This study retrospectively reviewed our single institute experience to clarify the optimal indication and timing of salvage surgery. Retrospective analysis of 159 consecutive cases with germ cell tumors identified 20 cases with salvage surgery. These cases were classified based on the radiological response to neoadjuvant treatment before salvage surgery into increase (growing group, five cases), no change (stable group, seven cases), and decrease (shrinkage group, eight cases) in tumor size. Changes in tumor markers, histological findings, and the pattern of failure after salvage surgery were reviewed...
March 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29581022/neuro-endoscopic-cylinder-surgery-and-5-aminolevulinic-acid-5-ala-photodynamic-diagnosis-of-deep-seated-intracranial-lesions
#3
Jungsu Choo, Kazuhito Takeuchi, Yuichi Nagata, Fumiharu Ohka, Yugo Kishida, Tadashi Watanabe, Yusuke Satoh, Tetsuya Nagatani, Kyozo Kato, Toshihiko Wakabayashi, Atsushi Natsume
BACKGROUND: Microscopic detection of intracranial brain tumors with 5-aminolevulinic acid (5-ALA) has proven extremely useful, and reports the use of 5-ALA have recently increased. However, few reports have described 5-ALA photodynamic diagnosis (PDD) using a neuro-endoscope. We performed neuro-endoscopic 5-ALA PDD for various brain lesions and present a procedure using only a neuro-endoscope. METHODS: We describe the diagnosis of 20 intracranial brain lesion cases with a 5-ALA-guided fluorescence endoscope...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29552538/granulomatous-response-in-intracranial-germinomas-diagnostic-problems
#4
Sree Rekha Jinkala, Elancheran Muthalagan, Bhawana Ashok Badhe
Intracranial germinomas are rare and account for <0.5% of primary intracranial tumors. In contrast to the gonadal germinomas, these do not show granulomatous response within the tumor. In rare cases, the granulomatous component may obscure the tumor proper and lead to diagnostic difficulties/dilemmas. We report a case of suprasellar germinoma in a 17-year-old boy which showed granulomatous response. We discuss the differentials to be considered in such a scenario and discuss the utility of squash cytology and immunohistochemistry in these lesions...
January 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29492156/widespread-intra-abdominal-carcinomatosis-from-a-rhabdoid-meningioma-after-placement-of-a-ventriculoperitoneal-shunt-a-case-report-and-review-of-the-literature
#5
N G Jun Jie, Kok Ann Teo, Asim Shabbir, Tseng Tsai Yeo
Intra-abdominal metastasis (IAM) of central nervous system (CNS) tumors via ventriculoperitoneal shunt (VPS) is rare but has been previously reported (e.g., germinomas and medulloblastomas). However, there has been no previous report in the literature involving meningiomas. A case of primary rhabdoid meningioma with widespread intra-abdominal carcinomatosis after placement of a VPS in a 36-year-old man is described. The patient underwent preoperative angioembolization of the tumor, craniotomy, and surgical excision, followed by postoperative gamma knife radiosurgery...
January 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29487768/suprasellar-germinoma-presenting-with-slipped-capital-femoral-epiphysis-case-report
#6
Keerthana Sankar, Wade Kyono, Corey Raffel, Theodore Nicolaides
Slipped capital femoral epiphysis (SCFE) is a fracture that results from displacement of the proximal femoral epiphysis from the femoral neck. SCFE can be caused by various endocrinopathies that lead to bone weakening in both adult and pediatric patients. We report a rare case of suprasellar germinoma presenting with SCFE in an 11-year-old female patient. The findings of this case further support the need to consider pituitary lesions as the underlying cause of endocrine deficiences leading to SCFE.
December 16, 2017: Curēus
https://www.readbyqxmd.com/read/29454505/current-management-of-intracranial-germ-cell-tumours
#7
A Bowzyk Al-Naeeb, M Murray, G Horan, F Harris, R-D Kortmann, J Nicholson, T Ajithkumar
Intracranial germ cell tumours (icGCTs) are uncommon tumours occurring in children and young adults. They are usually segregated into germinomas and non-germinomatous tumours (NGGCTs) in most classifications. Germinomas are highly curable tumours with multimodality treatment, but NGGCTs are associated with poorer survival outcomes. There are some differences in the approach to the management of icGCTs globally. Current research generally focuses on reducing treatment intensity, particularly the dose and volume of radiotherapy, in order to minimise the risks of late sequelae while maintaining high cure rates in icGCTs...
February 14, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29415126/central-nervous-system-germinomas-express-programmed-death-ligand-1
#8
Miriam E Wildeman, Matthew J Shepard, Edward H Oldfield, M Beatriz S Lopes
Immunomodulation and tumor-induced tolerance is one of the central mechanisms in the oncogenesis of malignant and benign neoplasms. While numerous pathways have been described, signaling through the programmed death receptor 1 (PD-1) on T lymphocytes, via activation through its ligand, programmed death ligand 1 (PD-L1) expressed on tumor cells is one of the central pathways involved in tumor-induced tolerance. While the neoplastic component of germinomas of the CNS is the germ cell, these tumors also exhibit an abundance of quiescent tumor-infiltrating lymphocytes...
February 5, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29378909/intracranial-germinoma-causing-cerebral-haemiatrophy-and-hypopituitarism
#9
Bruno Fukelmann Guedes, Marcio Nattan Portes Souza, Breno José Alencar Pires Barbosa, Fernando Pereira Frassetto, Leandro Tavares Lucato, Carla Rachel Ono, Luiz Henrique Martins Castro, Ricardo Nitrini, Mateus Mistieri Simabukuro
A young woman presented with primary amenorrhoea, progressive haemiparesis, visual disturbance, dementia and focal motor seizures. Investigations showed hypopituitarism, unilateral cerebral atrophy and inflamed cerebrospinal fluid. A trans-sphenoidal biopsy gave a unifying diagnosis of a pituitary germinoma.
January 29, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29335082/-a-comparative-analysis-of-anti-n-methyl-d-aspartate-receptor-encephalitis-with-or-without-abnormal-findings-on-cranial-magnetic-resonance-imaging
#10
COMPARATIVE STUDY
Jian-Zhao Zhang, Qian Chen, Ping Zheng, Li-Na Xie, Xiao-Li Yi, Hai-Tao Ren, Jian Yang
OBJECTIVE: To investigate the clinical features of children with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis with normal or abnormal cranial magnetic resonance imaging (MRI) findings via a comparative analysis. METHODS: A retrospective analysis was performed for the clinical data of 33 children with anti-NMDAR encephalitis. The clinical features and prognosis were compared between the children with normal and abnormal cranial MRI findings. RESULTS: In the 33 children with anti-NMDAR encephalitis, the most common initial symptoms were seizures (61%) and involuntary movement (61%), followed by language disorder (54%), mental and behavioral abnormalities (52%), and disturbance of consciousness (30%)...
January 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29325960/results-of-biopsy-proven-sellar-germ-cell-tumors-nine-years-experience-in-a-single-center
#11
Yi Zhang, Huijuan Zhu, Kan Deng, Wenbin Ma, Yu Wang, Jian Sun, Xin Lian, Hui Pan, Renzhi Wang, Yong Yao
BACKGROUND: The biopsy is recognized as the most accurate method to determine the histologic characterization of sellar germ cell tumors. It is difficult to evaluate the prognosis before histologic confirmation. OBJECTIVE: This study aimed to evaluate the independent prognostic risk factors of patients with sellar germ cell tumors (GCTs). METHODS: From January 2008 to December 2015, 61 patients who were histologically diagnosed as having sellar GCTs were followed up and were included in this retrospective study...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29324254/prdm14-is-expressed-in-germ-cell-tumors-with-constitutive-overexpression-altering-human-germline-differentiation-and-proliferation
#12
Joanna J Gell, Jasmine Zhao, Di Chen, Timothy J Hunt, Amander T Clark
Germ cell tumors (GCTs) are a heterogeneous group of tumors occurring in gonadal and extragonadal locations. GCTs are hypothesized to arise from primordial germ cells (PGCs), which fail to differentiate. One recently identified susceptibility loci for human GCT is PR (PRDI-BF1 and RIZ) domain proteins 14 (PRDM14). PRDM14 is expressed in early primate PGCs and is repressed as PGCs differentiate. To examine PRDM14 in human GCTs we profiled human GCT cell lines and patient samples and discovered that PRDM14 is expressed in embryonal carcinoma cell lines, embryonal carcinomas, seminomas, intracranial germinomas and yolk sac tumors, but is not expressed in teratomas...
March 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29274449/proton-magnetic-resonance-spectroscopy-detection-of-high-lipid-levels-and-low-apparent-diffusion-coefficient-is-characteristic-of-germinomas
#13
Fumiyuki Yamasaki, Yasuyuki Kinoshita, Takeshi Takayasu, Satoshi Usui, Manish Kolakshyapati, Motoki Takano, Sayuru Tsuyuguchi, Vishwa Jeet Amatya, Yuji Akiyama, Yukio Takeshima, Kazuhiko Sugiyama, Kaoru Kurisu
BACKGROUND: The differentiation of germinoma from other tumors by conventional magnetic resonance imaging (MRI) can be very difficult. The purpose of our study was to determine whether diffusion-weighted imaging (DWI) and single-voxel proton magnetic resonance spectroscopy (1H-MRS) could provide additional useful information for a definitive diagnosis of germinomas. METHODS: Our hospital's Institutional Review Board approved this retrospective study. We reviewed imaging studies of 26 patients with histologically confirmed germinomas who were treated at our hospital between 2003 and 2016...
April 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29237087/type-frequency-and-spatial-distribution-of-immune-cell-infiltrates-in-cns-germinomas-evidence-for-inflammatory-and-immunosuppressive-mechanisms
#14
Pia Zapka, Evelyn Dörner, Verena Dreschmann, Noriaki Sakamato, Glen Kristiansen, Gabriele Calaminus, Christian Vokuhl, Ivo Leuschner, Torsten Pietsch
Central nervous system germinomas are characterized by a massive immune cell infiltrate. We systematically characterized these immune cells in 28 germinomas by immunophenotyping and image analysis. mRNA expression was analyzed by Nanostring technology and in situ RNA hybridization. Tumor infiltrating lymphocytes (TILs) were composed of 61.8% ± 3.1% (mean ± SE) CD3-positive T cells, including 45.2% ± 3.5% of CD4-positive T-helper cells, 23.4% ± 1.5% of CD8-positive cytotoxic T cells, 5.5% ± 0...
February 1, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29232188/cerebral-germinoma-revealed-through-a-polydipsic-polyuric-syndrome-in-a-10-year-old-girl-case-report
#15
L Van Lierde, P Clapuyt, M C Nassogne, Philippe Oriot
Cerebral germinoma is rare. Although the imaging of the germinoma is very evocative, it's very polymorphic clinical expression is at the origin of misguided diagnosis, as illustrated in our case. We report the case of a 10-year-old girl with diabetes insipidus evolving for 12 months associated with a decrease in visual acuity. Brain MRI (Magnetic Resonance Imaging) revealed a tumor process in the suprasellar region. The stereotaxic biopsy of the tumor confirmed the diagnosis of the hypothalamic germinoma, which allowed the patient to be treated by radiotherapy and chemotherapy...
October 26, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/29177595/practice-patterns-and-survival-outcomes-of-intracranial-germinoma-an-analysis-of-the-national-cancer-database
#16
Wei Gang Wang, Hong Ye, Prakash Chinnaiyan
The goal of the study is to examine the practice pattern and survival outcome of adult and pediatric patients with intracranial germinoma. Patients from the National Cancer Database (NCDB) brain tumor registry between the years 2004-2014 with intracranial germinoma were extracted for analysis. Patients who had distant metastasis, received no treatments, or only surgery/chemotherapy alone were excluded. An age cutoff of > 21 years old was used to define the pediatric population. Patients were stratified by the treatments radiation therapy alone (RT) and chemotherapy followed by radiation therapy (C + RT)...
March 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29128947/t2-based-mr-imaging-gradient-echo-or-susceptibility-weighted-imaging-in-midline-and-off-midline-intracranial-germ-cell-tumors-a-pilot-study
#17
Giovanni Morana, Cesar Augusto Alves, Domenico Tortora, Jonathan L Finlay, Mariasavina Severino, Paolo Nozza, Marcello Ravegnani, Marco Pavanello, Claudia Milanaccio, Mohamad Maghnie, Andrea Rossi, Maria Luisa Garrè
PURPOSE: The role of T2*-based MR imaging in intracranial germ cell tumors (GCTs) has not been fully elucidated. The aim of this study was to evaluate the susceptibility-weighted imaging (SWI) or T2* gradient echo (GRE) features of germinomas and non-germinomatous germ cell tumors (NGGCTs) in midline and off-midline locations. METHODS: We retrospectively evaluated all consecutive pediatric patients referred to our institution between 2005 and 2016, for newly diagnosed, treatment-naïve intracranial GCT, who underwent MRI, including T2*-based MR imaging (T2* GRE sequences or SWI)...
January 2018: Neuroradiology
https://www.readbyqxmd.com/read/29118528/adult-testicular-cancer-two-decades-of-saudi-national-data
#18
REVIEW
Mohammed Abomelha
There is a paucity of data regarding testicular cancer among Saudis as well as the nonexistent of published national data. Furthermore, a substantial increase of the incidence of testicular cancer among Saudis was lately noted. The aim of the study is to determine the trends and patterns of testicular cancer among adult Saudis using national data over a period of 20 years. The national database of the Saudi Cancer Registry (SCR) on testicular cancer over the last two decades was studied including epidemiological and histological patterns...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29067503/clinical-features-radiologic-findings-and-treatment-of-pediatric-germ-cell-tumors-involving-the-basal-ganglia-and-thalamus-a-retrospective-series-of-15-cases-at-a-single-center
#19
Mengmeng Wang, Peizhi Zhou, Shizhen Zhang, Xueyou Liu, Liang Lv, Zeming Wang, Feng Ye, Yan Ju, Shu Jiang
PURPOSE: Pediatric germ cell tumors (GCTs) involving the basal ganglia and thalamus are relatively rare neoplasms which have not been extensively described. We here summarize the clinical and radiological features of a series of such tumors and discuss optimal treatment strategies based upon our experience. METHODS: A total of 15 pediatric patients with basal ganglionic and thalamic GCTs were treated between 2011 and 2016 at West China Hospital. Epidemiological characteristics, clinical features, imaging findings, and treatment strategies were reviewed retrospectively...
October 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29044451/pediatric-intracranial-germinoma-use-chemotherapy-first
#20
Anselm Lee, Timothy Lee, Tuck Loong Yang, Kim Shang Lee
No abstract text is available yet for this article.
August 31, 2017: Turkish Neurosurgery
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