Read by QxMD icon Read


Shusuke Yamamoto, Hideo Hamada, Shoichi Nagai, Satoshi Kuroda
We present a very rare case of suprasellar germinoma that spontaneously regressed before endoscopic biopsy. An 8-year-old boy was admitted to our hospital due to headache, polydipsia, and polyuria. Neurological examination performed on admission revealed bitemporal hemianopia. Enhanced MRI demonstrated a homogeneously enhanced tumor mass in the suprasellar region obstructing the foramen of Monro. Tests for all serum tumor markers were negative. Plain X-ray and CT scan were performed once and twice, respectively, for seven days between admission and endoscopic biopsy...
October 2016: No Shinkei Geka. Neurological Surgery
Y C Chou, C K Tseng
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Anas Abdallah, Murad Asilturk, Mustafa Levent Uysal, Erhan Emel, Betül Guler Abdallah, Bilge Bilgic, Gokcen Gundogdu
AIM: Primary intracranial germinomas (PIGs) are rare malignant brain tumors that represent approximately 0.2% to 1.7% of all primary intracranial tumors. PIGs have infrequent, but existent possibility of spinal cord metastases. In this study, clinical outcomes of five consecutive PIGs have been presented. MATERIAL AND METHODS: Medical records were retrospectively reviewed in 1,849 cases of intracranial tumors whom underwent surgery between the years 2005 and 2015, cases which confirmed as germinoma histopathologically were included in this study...
August 23, 2016: Turkish Neurosurgery
Marina Nikitović, Danica Grujičić, Milica Skender Gazibara, Dragana Stanić, Jelena Bokun, Milan Sarić
Primary spinal cord germinomas are an extremely rare group of tumors, most commonly reported as single cases in young Japanese adults. They usually present as intramedullary lesions located in the thoracic and thoracolumbar spine. The importance of preoperative diagnosis lies in the fact that by using radiotherapy and chemotherapy, even without surgery, a good cure rate can be achieved in patients with spinal cord germinoma. However, these tumors demonstrate unspecific imaging characteristics and only some secrete tumor markers...
August 20, 2016: World Neurosurgery
Aanchal Kakkar, Ahitgani Biswas, Nikhil Kalyani, Uttara Chatterjee, Vaishali Suri, Mehar C Sharma, Nishant Goyal, Bhawani S Sharma, Supriya Mallick, Pramod K Julka, Girish Chinnaswamy, Brijesh Arora, Epari Sridhar, Sandip Chatterjee, Rakesh Jalali, Chitra Sarkar
OBJECTIVE: Central nervous system germ cell tumors (CNS GCTs) are relatively rare neoplasms. Incidence of CNS GCTs in Western literature is low (0.3-0.6 %) as compared to East Asia (3-4 %). No large study is available on CNS GCTs from India. METHODS: Intracranial GCT cases were retrieved from databases of three tertiary care institutes in India; clinicopathological data was reviewed. RESULTS: Ninety-five intracranial GCT cases were identified, accounting for 0...
July 30, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Hui Zhang, Song-Tao Qi, Jun Fan, Lu-Xiong Fang, Bing-Hui Qiu, Yi Liu, Xiao-Yu Qiu
Whether bifocal germinomas (BFGs) synchronously presenting within the pineal region and the hypothalamo-neurohypophyseal axis (HNA) are primary germinomas of dual-origin remains to be elucidated. We analyzed MRI images and clinical features of 95 neurohypophyseal germinomas and 21 BFG patients and developed a tentative definition of the BFGs. We found dual-primary BFGs (true BFGs) do exist. The fundamental difference between primary and metastatic HNA germinomas was the direction of tumor growth. For a true BFG, the primary HNA tumor grew from the neurohypophysis toward the hypothalamus and almost invaded the whole pituitary stalk...
July 28, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Chia-Sui Kao, Muhammad T Idrees, Robert H Young, Thomas M Ulbright
Dr Robert E. Scully, who recognized and defined gonadoblastoma (GB), used the term "dissecting gonadoblastoma" (DGB) to describe variants with either an infiltrative type or diffuse pattern instead of the usual small nested arrangement. These patterns have not been emphasized in the literature. To investigate the features of DGB we examined 50 GBs microscopically and performed immunohistochemistry (IHC) in some. DGB was found in 38 (76%) GBs and was represented by 3 patterns. The most frequent was solid/expansile (n=26), consisting of large coalescent nests of germ cells, often (92%) interrupted by fibrovascular septa, with usually minor numbers of sex cord cells...
October 2016: American Journal of Surgical Pathology
Evan M Krueger, Darbi L Invergo, Julian J Lin
A 19-year-old Caucasian male presented with complaints of headaches and syncope. Suspicion of hydrocephalus prompted computed tomography (CT) and magnetic resonance imaging (MRI), which revealed pineal and suprasellar prominences with diffuse, thick, nodular subependymal enhancement of the lateral and third ventricles. Based on imaging, the differential diagnosis consisted primarily of malignancy, such as lymphoma, with inflammatory and infectious etiologies not excluded. Cerebrospinal fluid (CSF) samples were non-specific, and neuroendoscopic tissue biopsy histologically confirmed the diagnosis of pure germinoma...
2016: Curēus
Kohei Fukuoka, Takaaki Yanagisawa, Tomonari Suzuki, Mitsuaki Shirahata, Jun-Ichi Adachi, Kazuhiko Mishima, Takamitsu Fujimaki, Hideki Katakami, Masao Matsutani, Ryo Nishikawa
OBJECTIVE Human chorionic gonadotropin (HCG) can be detected in a certain population of patients with a germinoma, but the frequency of germinoma HCG secretion and the prognostic value of HCG in the CSF are unknown. METHODS The authors measured HCG levels in sera and CSF in patients with a histologically confirmed germinoma by using a highly sensitive assay known as an immune complex transfer enzyme immunoassay (EIA), which is more than 100 times as sensitive as the conventional method, and they analyzed the correlation between HCG levels and the prognoses of patients with a germinoma...
July 8, 2016: Journal of Neurosurgery. Pediatrics
Simone Laura Schulte, Andreas Waha, Barbara Steiger, Dorota Denkhaus, Evelyn Dörner, Gabriele Calaminus, Ivo Leuschner, Torsten Pietsch
CNS germinomas represent a unique germ cell tumor entity characterized by undifferentiated tumor cells and a high response rate to current treatment protocols. Limited information is available on their underlying genomic, epigenetic and biological alterations. We performed a genome-wide analysis of genomic copy number alterations in 49 CNS germinomas by molecular inversion profiling. In addition, CpG dinucleotide methylation was studied by immunohistochemistry for methylated cytosine residues. Mutational analysis was performed by resequencing of candidate genes including KIT and RAS family members...
July 4, 2016: Oncotarget
Xiang Huang, Rong Zhang, Ying Mao, Liang-Fu Zhou, Chao Zhang
BACKGROUND: Intracranial germ cell tumors (IGCTs) are a group of rare pediatric brain tumors which include various subtypes. The current understanding of the etiology of the tumors and their optimal management strategies remain controversial. DATA SOURCES: The data on IGCTs were collected from articles published in the past 20 years, and the origin and etiology of IGCTs at molecular level as well as the relative roles of varied treatment strategies in different prognosis groups according to Matsutani's classification were reviewed...
August 2016: World Journal of Pediatrics: WJP
Justyna Chalubinska-Fendler, Monika Bulas, Malgorzata Klonowicz, Wojciech Fendler, Jacek Fijuth, Wojciech Mlynarski
No abstract text is available yet for this article.
June 1, 2016: Archives of Medical Science: AMS
Clément Vialatte de Pémille, Franck Bielle, Karima Mokhtari, Esma Kerboua, Claire Alapetite, Ahmed Idbaih
Intracranial germinoma is a rare primary brain cancer, usually located within the midline and mainly affecting Asian pediatric patients. Interestingly, we report here the peculiar case of a young North-African adult patient suffering from a basal ganglia germinoma without the classical ipsilateral cerebral hemiatrophy associated with this location.
August 2016: World Neurosurgery
Kenneth Wong, Anthony B Opimo, Arthur J Olch, Sean All, Jonathan F Waxer, Desirae Clark, Justine Cheng, Alisha Chlebik, Anat Erdreich-Epstein, Mark D Krieger, Benita Tamrazi, Girish Dhall, Jonathan L Finlay, Eric L Chang
Primary intracranial germ cell tumors are rare, representing less than 5% of all central nervous system tumors. Overall, the majority of germ cell tumors are germinomas and approximately one-third are non-germinomatous germ cell tumors (NGGCT), which include teratoma, embryonal carcinoma, yolk sac tumor (endodermal sinus tumor), choriocarcinoma, or mixed malignant germ cell tumor. Germ cell tumors may secrete detectable levels of proteins into the blood and/or cerebrospinal fluid, and these proteins can be used for diagnostic purposes or to monitor tumor recurrence...
2016: Curēus
Marina T van Leeuwen, Howard Gurney, Jennifer J Turner, Sandra L Turner, Sallie-Anne Pearson, Maarit A Laaksonen, Paul Harnett, Bavanthi Balakrishnar, Dhanusha Sabanathan, Claire M Vajdic
PURPOSE: Germ cell tumour (GCT) aetiology is uncertain and comprehensive epidemiological studies of GCT incidence are few. METHODS: Nationwide data on all malignant GCTs notified to Australian population-based cancer registries during 1982-2011 were obtained. Age- and sex-specific, and World age-standardised incidence rates were calculated for paediatric (0-14) and adult (15+) cases using the latest WHO subtype classification scheme. Temporal trends were examined using Joinpoint regression...
August 2016: Cancer Epidemiology
Takahiro Aoki, Moeko Hino, Katsuyoshi Koh, Masashi Kyushiki, Hiroshi Kishimoto, Yuki Arakawa, Ryoji Hanada, Hiroshi Kawashima, Jun Kurihara, Naoki Shimojo, Shinichiro Motohashi
Programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8(+) T cells in formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD-L1 expression and germinoma contained abundant tumor-infiltrating CD8(+) T cells and PD-L1-positive macrophages...
August 2016: Pediatric Blood & Cancer
Yu-Ping Gao, Ji-Yao Jiang, Qiang Liu
Although primary central nervous system (CNS) germ cell tumors (GCTs) are one of the most treatable types of malignant brain tumor, a subset of patients remain resistant to standard chemotherapy. Gain-of-function mutations of the c-Kit gene, and KIT protein expression, have been observed in a number of GCTs, including testicular seminoma, ovarian dysgerminoma and mediastinal seminoma in various ethnic groups. Although a small number of studies have reported the role of c-Kit in CNS GCTs, few have focused on Chinese patients exhibiting CNS GCTs...
May 2016: Oncology Letters
Wendong Liu, Limin Wang, Minghua Liu, Guimei Li
Objective. In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed. This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI. Methods. The clinical, hormonal, and neuroradiological characteristics of children with CDI at diagnosis and during 1.5-2-year follow-up were collected and analyzed. Results. The study included 43 CDI patients. The mean interval between initial manifestation and diagnosis was 22...
2016: International Journal of Endocrinology
W Saeger
Inflammatory findings in the pituitary glands account for approximately 1 % of operations in the sellar region. Primary inflammation (e.g. lymphocytic and idiopathic granulomatous hypophysitis) have to be differentiated from secondary types (e.g. concomittant inflammation with Rathke's cleft cysts, craniopharyngiomas and germinomas) and involvement of the pituitary in generalized inflammation (IgG4-related disease, sarcoidosis and septicopyemia). Langerhans cell histiocytosis also has to be considered for the differential diagnostics...
May 2016: Der Pathologe
Roos Leroy, Nadia Benahmed, Frank Hulstaert, Nancy Van Damme, Dirk De Ruysscher
Because it spares many normal tissues and reduces the integral dose, proton therapy (PT) is the preferred tumor irradiation technique for treating childhood cancer. However, to the best of our knowledge, no systematic review of the clinical effectiveness of PT in children has been reported in the scientific literature. A systematic search for clinical outcome studies on PT published between 2007 and 2015 was performed in Medline (through OVID), EMBASE, and the Cochrane Library. Twenty-three primary studies were identified, including approximately 650 patients overall...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"