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https://www.readbyqxmd.com/read/29232188/cerebral-germinoma-revealed-through-a-polydipsic-polyuric-syndrome-in-a-10-year-old-girl-case-report
#1
Lierde Van, P Clapuyt, M C Nassogne, Philippe Oriot
Cerebral germinoma is rare. Although the imaging of the germinoma is very evocative, it's very polymorphic clinical expression is at the origin of misguided diagnosis, as illustrated in our case. We report the case of a 10-year-old girl with diabetes insipidus evolving for 12 months associated with a decrease in visual acuity. Brain MRI (Magnetic Resonance Imaging) revealed a tumor process in the suprasellar region. The stereotaxic biopsy of the tumor confirmed the diagnosis of the hypothalamic germinoma, which allowed the patient to be treated by radiotherapy and chemotherapy...
October 26, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/29177595/practice-patterns-and-survival-outcomes-of-intracranial-germinoma-an-analysis-of-the-national-cancer-database
#2
Wei Gang Wang, Hong Ye, Prakash Chinnaiyan
The goal of the study is to examine the practice pattern and survival outcome of adult and pediatric patients with intracranial germinoma. Patients from the National Cancer Database (NCDB) brain tumor registry between the years 2004-2014 with intracranial germinoma were extracted for analysis. Patients who had distant metastasis, received no treatments, or only surgery/chemotherapy alone were excluded. An age cutoff of > 21 years old was used to define the pediatric population. Patients were stratified by the treatments radiation therapy alone (RT) and chemotherapy followed by radiation therapy (C + RT)...
November 25, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29128947/t2-based-mr-imaging-gradient-echo-or-susceptibility-weighted-imaging-in-midline-and-off-midline-intracranial-germ-cell-tumors-a-pilot-study
#3
Giovanni Morana, Cesar Augusto Alves, Domenico Tortora, Jonathan L Finlay, Mariasavina Severino, Paolo Nozza, Marcello Ravegnani, Marco Pavanello, Claudia Milanaccio, Mohamad Maghnie, Andrea Rossi, Maria Luisa Garrè
PURPOSE: The role of T2*-based MR imaging in intracranial germ cell tumors (GCTs) has not been fully elucidated. The aim of this study was to evaluate the susceptibility-weighted imaging (SWI) or T2* gradient echo (GRE) features of germinomas and non-germinomatous germ cell tumors (NGGCTs) in midline and off-midline locations. METHODS: We retrospectively evaluated all consecutive pediatric patients referred to our institution between 2005 and 2016, for newly diagnosed, treatment-naïve intracranial GCT, who underwent MRI, including T2*-based MR imaging (T2* GRE sequences or SWI)...
November 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29118528/adult-testicular-cancer-two-decades-of-saudi-national-data
#4
REVIEW
Mohammed Abomelha
There is a paucity of data regarding testicular cancer among Saudis as well as the nonexistent of published national data. Furthermore, a substantial increase of the incidence of testicular cancer among Saudis was lately noted. The aim of the study is to determine the trends and patterns of testicular cancer among adult Saudis using national data over a period of 20 years. The national database of the Saudi Cancer Registry (SCR) on testicular cancer over the last two decades was studied including epidemiological and histological patterns...
October 2017: Urology Annals
https://www.readbyqxmd.com/read/29067503/clinical-features-radiologic-findings-and-treatment-of-pediatric-germ-cell-tumors-involving-the-basal-ganglia-and-thalamus-a-retrospective-series-of-15-cases-at-a-single-center
#5
Mengmeng Wang, Peizhi Zhou, Shizhen Zhang, Xueyou Liu, Liang Lv, Zeming Wang, Feng Ye, Yan Ju, Shu Jiang
PURPOSE: Pediatric germ cell tumors (GCTs) involving the basal ganglia and thalamus are relatively rare neoplasms which have not been extensively described. We here summarize the clinical and radiological features of a series of such tumors and discuss optimal treatment strategies based upon our experience. METHODS: A total of 15 pediatric patients with basal ganglionic and thalamic GCTs were treated between 2011 and 2016 at West China Hospital. Epidemiological characteristics, clinical features, imaging findings, and treatment strategies were reviewed retrospectively...
October 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29044451/pediatric-intracranial-germinoma-use-chemotherapy-first
#6
Anselm Lee, Timothy Lee, Tuck Loong Yang, Kim Shang Lee
No abstract text is available yet for this article.
August 31, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29036598/global-dna-methylation-analysis-reveals-mir-214-3p-contributes-to-cisplatin-resistance-in-pediatric-intracranial-nongerminomatous-malignant-germ-cell-tumors
#7
Tsung-Han Hsieh, Yun-Ru Liu, Ting-Yu Chang, Muh-Lii Liang, Hsin-Hung Chen, Hsei-Wei Wang, Yun Yen, Tai-Tong Wong
Background: Pediatric central nervous system germ cell tumors (CNSGCTs) are rare and heterogeneous neoplasms, and they can be divided into germinomas and nongerminomatous GCTs (NGGCTs). NGGCTs are further subdivided into mature teratomas and nongerminomatous malignant GCTs (NGMGCTs). Clinical outcomes suggest that NGMGCTs have poor prognosis and survival, and that they require more extensive radiotherapy and adjuvant chemotherapy. However, the mechanisms underlying this difference are still unclear...
October 3, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29026272/incidence-of-diabetes-mellitus-and-neoplasia-in-japanese-short-statured-children-treated-with-growth-hormone-in-the-genetics-and-neuroendocrinology-of-short-stature-international-study-genesis
#8
Susumu Yokoya, Tomonobu Hasegawa, Keiichi Ozono, Hiroyuki Tanaka, Susumu Kanzaki, Toshiaki Tanaka, Kazuo Chihara, Nan Jia, Christopher J Child, Katsuichiro Ihara, Jumpei Funai, Noriyuki Iwamoto, Yoshiki Seino
The primary goal of the Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) was to assess the safety and effectiveness of Humatrope(®), a GH preparation, in the treatment of pediatric patients with short stature. We report our findings in the GH-treated Japanese pediatric population focusing on the incidence of type 2 diabetes (T2D) and occurrence of neoplasms. A total of 2,345 Japanese patients were assessed for safety. During a mean observation period of 3.2 yr, T2D occurred in 3 patients (0...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/28946146/third-ventricle-germ-cell-tumor-originating-from-the-infundibulum-with-rapidly-expansive-enlargement
#9
Yuichiro Yoneoka, Junichi Yoshimura, Masakazu Sano, Masayasu Okada, Akiyoshi Kakita, Yukihiko Fujii
We present a pediatric case of a rapidly expanding third ventricle germ cell tumor (GCT). A 14-year-old boy suffered from gradual-onset central diabetes insipidus (DI) and received desmopressin treatment. Magnetic resonance imaging (MRI) showed nonspecific findings of the pituitary-hypothalamic axis. Nine months after the initial DI diagnosis, he developed progressively worsening headache. MRI demonstrated a third ventricle tumor causing noncommunicating hydrocephalus, although an MRI 16 weeks before admission did not show the lesion...
September 26, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28942513/loco-regional-extensions-of-central-nervous-system-germ-cell-tumors-a-retrospective-radiological-analysis-of-100-patients
#10
Loïc Duron, Flavie Sadones, Philippe Thiesse, Cécile Cellier, Claire Alapetite, François Doz, Didier Frappaz, Hervé J Brisse
PURPOSE: The current staging system of central nervous system (CNS) germ cell tumors (GCT) includes a binary classification in "localized" or "metastatic" disease based on the absence or presence of leptomeningeal dissemination. Loco-regional tumor dissemination has been barely described whereas its accurate definition might be useful in terms of prognosis and treatment, especially for radiation therapy planning. Our purpose was therefore to describe MR patterns and prevalence of loco-regional extensions of these tumors...
September 23, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28919233/craniospinal-germinomas-in-a-patient-with-down-syndrome-successfully-treated-with-standard-dose-chemotherapy-and-craniospinal-irradiation-a-case-report-and-literature-review
#11
Yohei Miyake, Jun-Ichi Adachi, Tomonari Suzuki, Kazuhiko Mishima, Atsushi Sasaki, Ryo Nishikawa
BACKGROUND: Patients with Down syndrome (DS) are more likely to develop chemotherapy-related complications. The standard treatment for these patients with cancers has not yet been established, and the risks of standard chemotherapy are unclear. In this paper, a rare case of multiple craniospinal germinomas in a patient with DS, which was successfully treated with standard-dose chemotherapy combined with craniospinal irradiation is reported. CASE DESCRIPTION: The authors report a case of multiple craniospinal germinomas in a DS patient who presented with bilateral oculomotor and facial nerve palsy and hearing loss...
September 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28888750/primary-mediastinal-pure-seminomatous-germ-cell-tumor-germinoma-as-a-rare-cause-of-precocious-puberty-in-a-9-year-old-patient
#12
Alejandra Bravo-Balado, Lynda Torres Castellanos, Adriana Carrillo Rodríguez, Daniel Gómez Zapata, Juan Javier Lammoglia Hoyos, Rafael Andrade, Jaime Pérez Niño
Less than 5%-7% of germ cell tumors are extragonadal, with the central nervous system being the most common location in children, followed by retroperitoneum and mediastinum. Only 10% of mediastinal tumors are malignant and one-third of these are pure seminomas (germinomas). We report the case of a 9-year-old boy with development of secondary sexual characteristics. Beta-human chorionic gonadotropin was elevated and a mediastinal mass was found. Final histology showed a pure seminomatous germ cell tumor. To our knowledge, this is the first report of a boy with precocious puberty secondary to a mediastinal germinoma...
September 6, 2017: Urology
https://www.readbyqxmd.com/read/28881049/classical-gonadoblastoma-its-relationship-to-the-dissecting-variant-and-undifferentiated-gonadal-tissue
#13
REVIEW
Lawrence M Roth, Liang Cheng
Classical gonadoblastoma occurs almost entirely in the dysgenetic gonads of an individual who has a disorder of sex development. Approximately 40% of such neoplasms are bilateral. Almost all gonadoblastomas occur in patients who have a Y chromosome or part thereof; testis-specific protein Y-encoded 1 (TSPY1) is the putative gene. If a gonad in a patient who has a disorder of sex development contains germ cells with delayed maturation, and also harbours the TSPY1 gene, the cells can undergo transformation to classical gonadoblastoma...
September 7, 2017: Histopathology
https://www.readbyqxmd.com/read/28819802/significance-of-human-chorionic-gonadotropin-as-a-predictor-of-resistance-to-standard-chemo-radiotherapy-for-pure-germinoma
#14
Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shinji Iwata, Shirabe Matsumoto, Masahiro Nishikawa, Saya Ozaki, Yawara Nakamura, Yosuke Mizuno, Riko Kitazawa, Takeharu Kunieda
Intracranial pure germinomas in children generally respond well to standard chemo-radiotherapy. However, some patients are refractory to standard therapy and require additional treatment. To investigate the characteristics of this subgroup, we retrospectively analyzed the clinical features and treatment outcomes of a cohort of 21 patients with intracranial pure germinomas who were diagnosed between April 2002 and December 2016 at Ehime University Hospital in Japan. Pure germinoma diagnosis was verified by histological examination of the tumor after surgery, and all patients received standard chemo-radiotherapy...
August 18, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28751141/histology-stratified-tumor-control-and-patient-survival-after-stereotactic-radiosurgery-for-pineal-region-tumors-a-report-from-the-international-gamma-knife-research-foundation
#15
Christian Iorio-Morin, Hideyuki Kano, Marshall Huang, L Dade Lunsford, Gabriela Simonová, Roman Liscak, Or Cohen-Inbar, Jason Sheehan, Cheng-Chia Lee, Hsiu-Mei Wu, David Mathieu
BACKGROUND: Pineal region tumors represent a rare and histologically diverse group of lesions. Few studies are available to guide management and the outcomes after stereotactic radiosurgery (SRS). METHODS: Patients who underwent SRS for a pineal region tumor and for whom at least 6 months of imaging follow-up was available were retrospectively assessed in 5 centers. Data were collected from the medical record and histology level analyses were performed, including actuarial tumor control and survival analyses...
November 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28711530/pitfalls-of-neuroendoscopic-biopsy-of-intraventricular-germ-cell-tumors
#16
Yasuyuki Kinoshita, Fumiyuki Yamasaki, Atsushi Tominaga, Taiichi Saito, Tetsuhiko Sakoguchi, Takeshi Takayasu, Satoshi Usui, Kazuhiko Sugiyama, Kazunori Arita, Kaoru Kurisu
OBJECTIVE: A neuroendoscopic biopsy has become common for the diagnosis of ventricular tumors. However, its utility in patients with germ cell tumors (GCTs) has not been well discussed. We examined the usefulness and pitfalls of neuroendoscopic biopsies of intraventricular GCTs at a single institution. METHODS: We retrospectively studied 21 consecutive patients diagnosed with GCTs by a neuroendoscopic biopsy of the ventricular region via the lateral ventricle. We examined the localization of tumors, histologic diagnoses using biopsies, surgical complications, and consistency of the diagnosis at the latest follow-up...
October 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28695992/optimal-radiotherapy-target-volumes-in-intracranial-nongerminomatous-germ-cell-tumors-long-term-institutional-experience-with-chemotherapy-surgery-and-dose-and-field-adapted-radiotherapy
#17
William G Breen, Miran J Blanchard, Amulya Nageswara Rao, David J Daniels, Jan C Buckner, Nadia N Issa Laack
PURPOSE: To evaluate patterns of failure after multimodality treatment of nongerminomatous germ cell tumors (NGGCTs). MATERIALS AND METHODS: We retrospectively reviewed records of 34 patients diagnosed with primary intracranial NGGCT between 1988 and 2014. RESULTS: Thirty-four patients received induction chemotherapy followed by radiation with or without surgery. Median follow-up was 11.1 years (0.8-23.3). Outcomes were significantly improved in these 34 patients (5-year overall survival [OS]: 88% versus 50%, P = 0...
November 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28693060/-an-analysis-of-four-cases-of-misdiagnosed-primary-lymphocytic-hypophysitis
#18
Q Wei, L Zang, Y J Li, W J Gu, N Jin, Q H Guo, J Du, J M Ba, Z H Lyu, J M Lu, J T Dou, Y M Mu, G Q Yang
To improve the differential diagnosis of sellar region mass, 4 cases with sellar mass and misdiagnosed as lymphocytic hypophysitis (LYH) were reviewed retrospectively.The 4 patients (2 male and 2 female) aged 20-60 years old were all presented with symptoms of headache, polydipsia and polyuria.Biochemical studies confirmed the diagnoses of central diabetes insipidus and hypopituitarism.Head MRI scans showed LYH like image for all the cases, and, thus, high dose methylprednisolone pulse therapy (HDMPT) was applied to the patients...
July 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28689343/a-rare-case-report-and-literatures-review-on-primary-germinoma-in-cerebellar-hemisphere
#19
Lei Wang, Wanchun Zhu, Xiang Li, Jintao He, Chunde Li, Jian Gong
OBJECT: Primary intracranial germinoma is a rare intracranial lesion which accounts for approximately 0.5-2% of all intracranial tumors. Generally, primary intracranial germinoma occurs in the midline structures of the central nervous system of a pediatric patient. Only four cases of primary cerebellar germinomas with poor prognosis have been previously reported. The object of this paper is to introduce a case of germinoma originating from cerebellar hemisphere and to discuss its clinical features...
November 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28614211/mixed-gonadal-germ-cell-tumor-composed-of-a-spermatocytic-tumor-like-component-and-germinoma-arising-in-gonadoblastoma-in-a-phenotypic-woman-with-a-46-xx-peripheral-karyotype-report-of-the-first-case
#20
Alejandro A Gru, Eli S Williams, Dengfeng Cao
We report a unique case of gonadal mixed germ cell tumor (GCT) composed of a predominantly spermatocytic tumor (ST)-like component and a minor component of germinoma arising in gonadoblastoma in a phenotypic woman with a 46, XX peripheral karotype. The patient was a 24-year-old woman (gravida 2, para 1) found to have a 7 cm pelvic mass during routine obstetric ultrasound examination at 20 weeks gestational age. She underwent a left salpingo-gonadectomy at gestational age 23 and 2/7 weeks. She recovered well and delivered a healthy baby at full term...
September 2017: American Journal of Surgical Pathology
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