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https://www.readbyqxmd.com/read/28614211/mixed-gonadal-germ-cell-tumor-composed-of-a-spermatocytic-tumor-like-component-and-germinoma-arising-in-gonadoblastoma-in-a-phenotypic-woman-with-a-46-xx-peripheral-karyotype-report-of-the-first-case
#1
Alejandro A Gru, Eli S Williams, Dengfeng Cao
We report a unique case of gonadal mixed germ cell tumor (GCT) composed of a predominantly spermatocytic tumor (ST)-like component and a minor component of germinoma arising in gonadoblastoma in a phenotypic woman with a 46, XX peripheral karotype. The patient was a 24-year-old woman (gravida 2, para 1) found to have a 7 cm pelvic mass during routine obstetric ultrasound examination at 20 weeks gestational age. She underwent a left salpingo-gonadectomy at gestational age 23 and 2/7 weeks. She recovered well and delivered a healthy baby at full term...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28614087/intracranial-germinoma-systemic-chemotherapy-in-addition-to-dose-reduced-radiation-therapy
#2
Lauren Chiec, Richard Curry, Nagla A Karim
No abstract text is available yet for this article.
June 13, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28602629/radiotherapy-and-chemotherapy-plus-radiation-in-the-treatment-of-patients-with-pure-intracranial-germinoma-a-meta-analysis
#3
REVIEW
Hanhui Fu, Xiaopeng Guo, Ran Li, Bing Xing
OBJECTIVE: To evaluate the efficiency of radiotherapy (RT) only and chemotherapy plus radiotherapy (CRT) strategy in the treatment of pure intracranial germinoma. METHODS: We searched PUBMED, EMBASE, Medline and Cochrane library up to May 2016 for studies that enrolled patients with pure intracranial germinoma receiving either RT only or CRT treatment as their first-line treatment. The meta-analysis was conducted on the overall survival rate (OS) and disease free survival (DFS) at 3years and 5years...
June 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28551848/mri-features-of-pediatric-intracranial-germ-cell-tumor-subtypes
#4
Chih-Chun Wu, Wan-Yuo Guo, Feng-Chi Chang, Chao-Bao Luo, Han-Jui Lee, Yi-Wei Chen, Yi-Yen Lee, Tai-Tong Wong
Intracranial germ cell tumors differ in histology and location, and require different clinical management strategies. We characterized the imaging features that may aid pre-operative differentiation of intracranial germinomas and non-germinomatous germ cell tumors (NGGCTs). This retrospective study analyzed 85 patients with intracranial germ cell tumors and adequate preoperative or pretreatment MRIs between 2000 and 2013 at our institution. Pretreatment MRI characteristics, apparent diffusion coefficient (ADC) values, tumor histopathology, and patient outcomes were compared...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551652/successful-treatment-of-pituitary-germinoma-with-etoposide-cisplatin-vincristine-methotrexate-and-bleomycin-chemotherapy-without-radiotherapy
#5
Amina Scherz, Katrin Feller, Sabina Berezowska, Vera Genitsch, Martin Zweifel
We report on the case of a 25-year-old man with pituitary germinoma. The patient had noticed polydipsia, reduced sexual function, and loss of body hair. Laboratory investigations confirmed panhypopituitarism including diabetes insipidus. Magnetic resonance imaging of the brain showed a 14×8.4 mm enhancing lesion of the pituitary stalk and histopathology of the neurosurgical biopsy confirmed pituitary germinoma. The patient was treated with 3 cycles of chemotherapy, consisting of 150 mg/m(2) etoposide and 75 mg/m(2) cisplatin, with the administration of intrathecal 12...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28549594/-recommendations-for-the-organ-donation-from-patients-with-brain-or-medullary-primitive-tumors-on-behalf-of-the-association-of-the-neuro-oncologists-of-french-expression-anocef-and-the-club-of-neuro-oncology-of-the-french-society-of-neurosurgery
#6
Didier Frappaz, Emilie Le Rhun, Arnaud Dagain, Benoît Averland, Luc Bauchet, Alexandre Faure, Christian Guillaume, Sonia Zouaoui, François Provot, Florence Vachiery, Luc Taillandier, Khê Hoang-Xuan
Requests of organs to be transplanted increase. As a matter of urgency, it is not always easy to decide if a patient carrier of a brain tumor can be candidate in the donation. After a review of the literature, the members of the Association of the Neuro-oncologists of French Expression (ANOCEF) and the Club of Neuro-oncology of the French Society of Neurosurgery propose consensual recommendations in case of donor carrier of primitive tumor intra-cranial or intra-medullary. A contact with the neuro-oncologist/neurosurgeon will allow to discuss the indication in case of glioma of grade I/II/III, according to the grade, the current status (absence of progressive disease), the number of surgeries and of lines of treatment...
May 23, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28529055/intraoperative-mapping-and-monitoring-of-the-pyramidal-tract-using-endoscopic-depth-electrodes
#7
Yukinori Akiyama, Shunya Ohtaki, Katsuya Komatsu, Kentaro Toyama, Rei Enatsu, Takeshi Mikami, Masahiko Wanibuchi, Nobuhiro Mikuni
OBJECTIVE: To evaluate motor function during neuroendoscopic resectioning of deep-seated brain tumors using endoscopically guided depth electrodes. METHODS: For 12 cases of thalamic tumors including high-grade gliomas, germinomas, and malignant lymphomas, depth electrodes were inserted using endoscopic guides between the tumor and the pyramidal tract in the thalamus. Motor evoked potentials (MEPs) were continuously recorded during neuroendoscopic resectioning of the tumors...
May 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28528422/5-ala-fluorescence-guided-endoscopic-surgery-for-mixed-germ-cell-tumors
#8
Junichi Takeda, Masahiro Nonaka, Yi Li, Yumiko Komori, Takamasa Kamei, Ryoichi Iwata, Tetsuo Hashiba, Kunikazu Yoshimura, Akio Asai
5-Aminolevulinic acid (5-ALA) fluorescence-guided surgery is widely used for detection and planning of resection of malignant gliomas and other brain tumors. However, no reports have described 5-ALA fluorescence-guided surgery or direct visualization of germ cell tumors. Here, we report two cases of germ cell tumors in which a positive 5-ALA fluorescent signal was visualized with a neuroendoscope. Both cases had a tumor in the pineal region that was associated with hydrocephalus. The patients underwent surgery after administration of 5-ALA...
May 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28483362/adipsic-diabetes-insipidus-revealing-a-bifocal-intracranial-germinoma
#9
Julie Kreutz, Iulia Potorac, Laurence Lutteri, Christine Gennigens, Didier Martin, Adrian F Daly, Jean-Francois Bonneville, Luaba Tshibanda, Albert Beckers
Adipsic diabetes insipidus is a rare complication of intracranial tumors in which impaired antidiuretic hormone secretion is associated with the loss of thirst sensation. Here, we present the case of a patient with bifocal intracranial germinoma, diagnosed due to symptoms mainly caused by adipsic diabetes insipidus. This is, to our knowledge, the first case of adipsic diabetes insipidus revealing an intracranial germinoma reported in the literature. We describe the diagnostic procedures and the three-year follow-up of this patient...
May 5, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28463397/treatment-and-outcomes-of-uk-and-german-patients-with-relapsed-intracranial-germ-cell-tumors-following-uniform-first-line-therapy
#10
Matthew J Murray, Shivani Bailey, Katja Heinemann, Jillian Mann, Ulrich K Göbel, Frank Saran, Juliet P Hale, Gabriele Calaminus, James C Nicholson
We aimed to retrospectively assess treatments/outcomes, including the value of high-dose-chemotherapy and autologous-stem-cell-rescue (HDC + AuSCR) and re-irradiation, in a large, European patient-cohort with relapsed intracranial germ-cell-tumors (GCTs) receiving uniform first-line therapy, including radiotherapy as standard-of-care. Fifty-eight UK/German patients (48 male/10 female) with relapsed intracranial-GCTs [13 germinoma/45 non-germinomatous GCT (NGGCT)] treated 1996-2010 as per the SIOP-CNS-GCT-96 protocol were evaluated...
August 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28445692/perspectives-on-testicular-sex-cord-stromal-tumors-and-those-composed-of-both-germ-cells-and-sex-cord-stromal-derivatives-with-a-comparison-to-corresponding-ovarian-neoplasms
#11
Lawrence M Roth, Bingjian Lyu, Liang Cheng
Sex cord-stromal tumors (SCSTs) are the second most frequent category of testicular neoplasms, accounting for approximately 2-5% of cases. Both genetic and epigenetic factors account for the differences in frequency and histologic composition between testicular and ovarian SCSTs. For example, large cell calcifying Sertoli cell tumor and intratubular large cell hyalinizing Sertoli cell neoplasia occur in the testis but have not been described in the ovary. In this article, we discuss recently described diagnostic entities as well as inconsistencies in nomenclature used in the recent World Health Organization classifications of SCSTs in the testis and ovary...
April 23, 2017: Human Pathology
https://www.readbyqxmd.com/read/28444954/clinical-presentation-and-outcome-of-children-with-central-diabetes-insipidus-associated-with-a-self-limited-or-transient-pituitary-stalk-thickening-diagnosed-as-infundibuloneurohypophysitis
#12
J Schaefers, M Cools, K De Waele, I Gies, V Beauloye, P Lysy, I Francois, D Beckers, J De Schepper
OBJECTIVE: Despite lymphocytic or autoimmune infundibuloneurohypophysitis (INH) is an increasingly recognized aetiology in children with central diabetes insipidus (CDI); clinical data on epidemiology (clinical evolution, predisposing factors, complications), diagnosis and management of this entity are limited and mostly based on published case reports. The aim of this study was to gain a broader insight in the natural history of this disease by analysing the clinical presentation, radiological pituitary stalk changes, associated autoimmunity and hormonal deficiencies in children with CDI and a self-limiting or transient stalk thickening (ST), diagnosed as autoimmune infundibuloneurohypophysitis, during the last 15 years in four Belgian university hospitals...
April 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28436607/visual-complaints-in-intracranial-germinomas
#13
Didier Frappaz, Claire Pedone, Philippe Thiesse, Alexandru Szathmari, Cécile Faure Conter, Carmine Mottolese, Christian Carrie
OBJECTIVE: Patients with brain tumors often report having visual complaints. This may be due to increased intracranial pressure, compression/invasion of the optic pathway or diplopia. We assessed the incidence and the etiology of visual symptoms in patients with intracranial germinoma tumors (ICGTs). METHODS AND MATERIALS: We performed a blinded retrospective review of the clinical charts and the initial magnetic resonance imaging (MRI) of 28 patients with ICGT...
April 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28413537/progressive-hemiparesis-in-a-young-man-hemicerebral-atrophy-as-the-initial-manifestation-of-basal-ganglia-germinoma
#14
Peter Yat Ming Woo, Alberto Chi Ho Chu, Kwong Yau Chan, John Ching Kwong Kwok
Basal ganglia germinomas are rare and patients are classically young Oriental males presenting with gradually progressive hemiparesis. Although early treatment with chemo-radiotherapy can be curative and significantly improve the quality of life, medical attention is often delayed. A young Chinese male experienced a 6-month history of right hemiparesis with magnetic resonance imaging findings of hemicerebral atrophy and lentiform nucleus microhemorrhage, highly suggestive and early signs of basal ganglia germinomas...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28247123/identification-of-characteristic-features-of-pineal-germinoma-that-enhance-accuracy-of-preoperative-differentiation-in-pineal-region-tumors-its-significance-on-optimum-surgical-treatment
#15
Akihiro Inoue, Takanori Ohnishi, Shohei Kohno, Shiro Ohue, Shinji Iwata, Shirabe Matsumoto, Masahiro Nishikawa, Saya Ozaki, Yosuke Mizuno, Riko Kitazawa, Takeharu Kunieda
The aim of the study is to identify characteristic features of pineal germinoma that enhance preoperative accuracy in differentiating germinoma from other pineal region tumors. Twenty-one consecutive patients with pineal region tumors were enrolled. In all patients, tumor resection was performed to verify the histology. Clinical records including upward gaze palsy of Parinaud's syndrome and neuroimaging were analyzed. In addition, we evaluated the relationship between magnetic resonance imaging (MRI) findings and tumor progression patterns in pineal germinoma...
March 1, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28236067/mixed-pineal-mature-teratoma-and-germinoma-in-two-brothers-of-the-fraternal-triplets
#16
Gordan Grahovac, Tord Alden, Wadhwani Nitin
INTRODUCTION: Intracranial teratomas are rare germ cell neoplasms that contain tissues derived from all three germ cell layers and most commonly occurring during childhood. This is the first report of pineal region mixed mature teratoma and germinoma in two fraternal brothers of fraternal triplets. CASE PRESENTATION: We report the case of a mixed mature teratoma and germinoma of the pineal region in two brothers of fraternal triplets. Older brother was initially diagnosed at the age of 11 years with the pure teratoma of the pineal region but the review of the pathology 3 years after initial surgery revealed the mixed mature teratoma with 5% germinomatous component...
February 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28228150/a-comparative-study-of-dose-distribution-of-pbt-3d-crt-and-imrt-for-pediatric-brain-tumors
#17
COMPARATIVE STUDY
Daichi Takizawa, Masashi Mizumoto, Tetsuya Yamamoto, Yoshiko Oshiro, Hiroko Fukushima, Takashi Fukushima, Toshiyuki Terunuma, Toshiyuki Okumura, Koji Tsuboi, Hideyuki Sakurai
INTRODUCTION: It was reported that proton beam therapy (PBT) reduced the normal brain dose compared with X-ray therapy for pediatric brain tumors. We considered whether there was not the condition that PBT was more disadvantageous than intensity modulated photon radiotherapy (IMRT) and 3D conventional radiotherapy (3D-CRT) for treatment of pediatric brain tumors about the dose reduction for the normal brain when the tumor location or tumor size were different. METHODS: The subjects were 12 patients treated with PBT at our institute, including 6 cases of ependymoma treated by local irradiation and 6 cases of germinoma treated by irradiation of all four cerebral ventricles...
February 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28202423/hypothalamic-pituitary-germinoma-presenting-as-generalized-hypohidrosis
#18
Atsushi Fukunaga, Shoko Tajima, Takashi Sasayama, Kazuhiro Tanaka, Yutaka Takahashi, Chikako Nishigori
No abstract text is available yet for this article.
February 15, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28096196/craniospinal-irradiation-using-helical-tomotherapy-for-central-nervous-system-tumors
#19
Sanziana R I Schiopu, Gregor Habl, Matthias Häfner, Sonja Katayama, Klaus Herfarth, Juergen Debus, Florian Sterzing
The aim of this study was to describe early and late toxicity, survival and local control in 45 patients with primary brain tumors treated with helical tomotherapy craniospinal irradiation (HT-CSI). From 2006 to 2014, 45 patients with central nervous system malignancies were treated with HT-CSI. The most common tumors were medulloblastoma in 20 patients, ependymoma in 10 patients, intracranial germinoma (ICG) in 7 patients, and primitive neuroectodermal tumor in 4 patients. Hematological toxicity during treatment included leukopenia Grades 1-4 (6...
March 1, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28078450/genome-wide-methylation-profiles-in-primary-intracranial-germ-cell-tumors-indicate-a-primordial-germ-cell-origin-for-germinomas
#20
Shintaro Fukushima, Satoshi Yamashita, Hisato Kobayashi, Hirokazu Takami, Kohei Fukuoka, Taishi Nakamura, Kai Yamasaki, Yuko Matsushita, Hiromi Nakamura, Yasushi Totoki, Mamoru Kato, Tomonari Suzuki, Kazuhiko Mishima, Takaaki Yanagisawa, Akitake Mukasa, Nobuhito Saito, Masayuki Kanamori, Toshihiro Kumabe, Teiji Tominaga, Motoo Nagane, Toshihiko Iuchi, Koji Yoshimoto, Masahiro Mizoguchi, Kaoru Tamura, Keiichi Sakai, Kazuhiko Sugiyama, Mitsutoshi Nakada, Kiyotaka Yokogami, Hideo Takeshima, Yonehiro Kanemura, Masahide Matsuda, Akira Matsumura, Kazuhiko Kurozumi, Keisuke Ueki, Masahiro Nonaka, Akio Asai, Nobutaka Kawahara, Yuichi Hirose, Tatusya Takayama, Yoichi Nakazato, Yoshitaka Narita, Tatsuhiro Shibata, Masao Matsutani, Toshikazu Ushijima, Ryo Nishikawa, Koichi Ichimura
Intracranial germ cell tumors (iGCTs) are the second most common brain tumors among children under 14 in Japan. The World Health Organization classification recognizes several subtypes of iGCTs, which are conventionally subclassified into pure germinoma or non-germinomatous GCTs. Recent exhaustive genomic studies showed that mutations of the genes involved in the MAPK and/or PI3K pathways are common in iGCTs; however, the mechanisms of how different subtypes develop, often as a mixed-GCT, are unknown. To elucidate the pathogenesis of iGCTs, we investigated 61 GCTs of various subtypes by genome-wide DNA methylation profiling...
March 2017: Acta Neuropathologica
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