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Hui Ding, Rongyu Wang, Xiao Wang, Wenhua Ji
Molecularly imprinted covalent organic polymers were constructed by an imine-linking reaction between 1,3,5-triformylphloroglucinol and 2,6-diaminopyridine and used for the selective solid-phase extraction of benzoxazole fluorescent whitening agents from food samples. Binding experiments showed that imprinting sites on molecularly imprinted polymers had higher selectivity for targets compared with those of the corresponding non-imprinted polymers. Parameters affecting the solid-phase extraction procedure were examined...
June 21, 2018: Journal of Separation Science
Afarin Rahimi-Movaghar, Jaleh Gholami, Laura Amato, Leila Hoseinie, Reza Yousefi-Nooraie, Masoumeh Amin-Esmaeili
BACKGROUND: Pharmacologic therapies for management of heroin withdrawal have been studied and reviewed widely. Opium dependence is generally associated with less severe dependence and milder withdrawal symptoms than heroin. The evidence on withdrawal management of heroin might therefore not be exactly applicable for opium. OBJECTIVES: To assess the effectiveness and safety of various pharmacologic therapies for the management of the acute phase of opium withdrawal...
June 21, 2018: Cochrane Database of Systematic Reviews
Claire Beaufay, Allison Ledoux, Olivia Jansen, Annélise Bordignon, Senzhi Zhao, Christiana N Teijaro, Rodrigo B Andrade, Joëlle Quetin-Leclercq, Michel Frédérich
Strychnogucine B is a bisindole alkaloid previously isolated from Strychnos icaja that possesses promising in vitro antiplasmodial properties. This compound was synthesized in four steps from (-)-strychnine. As no acute toxicity was observed at the highest tested cumulative dose of 60 mg/kg, its in vivo antimalarial activity was determined intraperitoneally at 30 mg/kg/d in a Plasmodium berghei murine model. In the Peters's 4-d suppressive test, this alkaloid suppressed the parasitaemia by almost 36% on day 5 and 60% on day 7 compared to vehicle-treated mice...
June 21, 2018: Planta Medica
Marina Weißenborn, Martin Schulz, Manuel Kraft, Walter E Haefeli, Hanna M Seidling
AIM OF THE STUDY: Collaboration between general practitioners and community pharmacists is essential to ensure safe and effective patient care. However, collaboration in primary care is not standardized and varies greatly. This review aims to highlight projects about professional collaboration in ambulatory care in Germany and identifies promising approaches and successful benchmarks that should be considered for future projects. METHODS: A systematic literature search was performed based on the PRISMA guidelines to identify articles focusing on professional collaboration between general practitioners and pharmacists...
June 21, 2018: Das Gesundheitswesen
Safa Alqudah, Mark Chertoff, Dianne Durham, Jackob Moskovitz, Hinrich Staecker, Marcello Peppi
Methionine sulfoxide reductases (MsrA and MsrB) protect the biological activity of proteins from oxidative modifications to methionine residues and are important for protecting against the pathological effects of neurodegenerative diseases. In the current study, we characterized the auditory phenotype of the MsrA knockout mouse. Young MsrA knockout mice showed small high-frequency threshold elevations for auditory brainstem response and distortion product otoacoustic emission compared to those of wild-type mice, which progressively worsened in older MsrA knockout mice...
June 21, 2018: Audiology & Neuro-otology
Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu, Jianbin Gong
BACKGROUND/AIMS: Toll-like receptors (TLRs) have been implicated in myocardial ischemia/ reperfusion (I/R) injury. We examined the effect of CpG-oligodeoxynucleotide (ODN) on myocardial I/R injury. METHODS: Male Sprague-Dawley rats were treated with either CpG-ODN or control ODN 1 h prior to myocardial ischemia (30 min) followed by reperfusion. Rats treated with phosphate-buffered saline (PBS) served as I/R controls (n = 8/group). Infarct size was determined by 2,3,5-triphenyltetrazolium chloride and Evans blue straining...
June 19, 2018: Cellular Physiology and Biochemistry
Susanne Penzel, Albert A Smith, Matthias Ernst, Beat H Meier
Fast magic-angle spinning, coupled with 1 H detection is a powerful method to improve spectral resolution and signal to noise in solid-state NMR spectra. Commercial probes now provide spinning frequencies in excess of 100 kHz. Then, one has sufficient resolution in the 1 H dimension to directly detect protons, which have a gyromagnetic ratio approximately four times larger than 13 C spins. However, the gains in sensitivity can quickly be lost if the rotation angle is not set precisely. The most common method of magic-angle calibration is to optimize the number of rotary echoes, or sideband intensity, observed on a sample of KBr...
June 15, 2018: Journal of Magnetic Resonance
Irfan Ullah, Ali Haider, Nasir Khalid, Saqib Ali, Sajjad Ahmed, Yaqoob Khan, Nisar Ahmed, Muhammad Zubair
Tungsten-doped TiO2 (W@TiO2 ) nanoparticles, with different percentages of atomic tungsten dopant levels (range of 0 to 6 mol%) have been synthesized by the sol-gel method and characterized by UV-Visible spectroscopy, XRD, SEM, EDX, ICP-OES and XPS analysis. By means of UV-Vis spectroscopy, it has been observed that with 6 mol% tungsten doping the wavelength range of excitation of TiO2 has extended to the visible portion of spectrum. Therefore, we evaluated the photocatalytic activity of W@TiO2 catalysts for the degradation of Congo red dye under varying experimental parameters such as dopant concentration, catalyst dosage, dye concentrations and pH...
June 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Mark D Baker, Bassel W Abou-Khalil, Amir Arain, Pavan Tummala, Nabil J Azar, Kevin F Haas, Hasan H Sonmezturk
OBJECTIVES: Post marketing analysis of anti-epileptic drug (AED) efficacy and tolerability is of great value to the clinician since it is more representative of clinical practice than clinical trial data. We analyzed our experience with lacosamide (LCM) in patients treated after marketing. PATIENTS AND METHODS: We identified all patients who were treated with LCM during the four year period after marketing, excluding patients who were in clinical trials. We recorded demographic data and analyzed efficacy and tolerability in patients who had at least one follow up visit or telephone call 3 months after the initiation of LCM...
June 13, 2018: Clinical Neurology and Neurosurgery
Beilei Huang, Qiusheng Xu, Ru Ye, Jun Xu
Tranexamic acid might be beneficial for cerebral hemorrhage. However, the results remained controversial. We conducted a systematic review and meta-analysis to explore the influence of tranexamic acid on cerebral hemorrhage. PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases were systematically searched. Randomized controlled trials (RCTs) assessing the effect of tranexamic acid on cerebral hemorrhage were included. Two investigators independently searched articles, extracted data, and assessed the quality of included studies...
June 12, 2018: Clinical Neurology and Neurosurgery
Shengchang Zhang, Lin Wu, Jin Cao, Kaili Wang, Yanru Ge, Wanjun Ma, Xueyong Qi, Song Shen
Nanoparticles based multifunctional system exhibits great potential in diagnosis and therapy of rheumatoid arthritis (RA). The size of nanoparticles plays an essential role in biodistribution and cellular uptake, in turn affects the drug delivery efficiency and therapeutic effect. To investigate the optimal size for RA targeting, Fe3 O4 nanoparticles with well-defined particle sizes (70-350 nm) and identical surface properties were developed as model nanoparticles. The synthesized Fe3 O4 nanoparticles exhibited excellent biocompatibility and showed higher temperature response under irradiation of near infrared light...
June 13, 2018: Colloids and Surfaces. B, Biointerfaces
Samuel Pitcairn, Bryson Lesniak, William Anderst
BACKGROUND: The patellofemoral (PF) joint is a common site for non-specific anterior knee pain. The pathophysiology of patellofemoral pain may be related to abnormal motion of the patella relative to the femur, leading to increased stress at the patellofemoral joint. Patellofemoral motion cannot be accurately measured using conventional motion capture. RESEARCH QUESTION: The aim of this study was to determine the accuracy of a biplane radiography system for measuring in vivo PF motion during walking and stair ascent...
June 18, 2018: Gait & Posture
Farzana Kastury, E Smith, Ranju R Karna, Kirk G Scheckel, A L Juhasz
In this study, methodological factors influencing the dissolution of metal(loid)s in simulated lung fluid (SLF) was assessed in order to develop a standardised method for the assessment of inhalation bioaccessibility in PM2.5 . To achieve this aim, the effects of solid to liquid (S/L) ratio (1:100 to 1:5000), agitation (magnetic agitation, occasional shaking, orbital and end-over-end rotation), composition of SLF (artificial lysosomal fluid: ALF; phagolysosomal simulant fluid: PSF) and extraction time (1-120 h) on metal(loid) bioaccessibility were investigated using PM2...
June 7, 2018: Environmental Pollution
Yuko Hakamata, Shinya Mizukami, Shotaro Komi, Eisuke Sato, Yoshiya Moriguchi, Yuki Motomura, Kazushi Maruo, Shuhei Izawa, Yoshiharu Kim, Takashi Hanakawa, Yusuke Inoue, Hirokuni Tagaya
INTRODUCTION: Attentional bias modification (ABM) alleviates anxiety by moderating biased attentional processing toward threat; however, its neural mechanisms remain unclear. We examined how ABM changes functional connectivity (FC) and functional network measures, leading to anxiety reduction. METHODS: Fifty-four healthy anxious individuals received either ABM or sham training for 1 month in a double-blind randomized controlled trial. Anxious traits, attentional control, and attentional bias were assessed...
June 5, 2018: Journal of Affective Disorders
João Mauricio Castaldelli-Maia, Silvia S Martins, Natalie Walker
BACKGROUND: There is just one study comparing the effectiveness of cytisine and nicotine replacement therapy (NRT) for smoking cessation. In the Russian Federation, both products are widely available as over-the-counter medications. Data on the real-world use of these medications among the general population would be informative. METHODS: Cross-sectional study using data from a nationally representative household survey of adults aged ≥ 15 years from the Russian Federation (part of the Global Tobacco Surveillance System Data)...
June 18, 2018: International Journal on Drug Policy
Youbing Zhu, Shuili Yu, Bing Zhang, Jianfeng Li, Dongsheng Zhao, Zhengyang Gu, Chao Gong, Guicai Liu
Alkali/surfactant/polymer (ASP) flooding wastewater is highly caustic, and membrane fouling is the main obstacle during ASP ultrafiltration (UF) treatment. To maintain favorable filtration performance, polytetrafluoroethylene (PTFE) and polyvinylidene fluoride (PVDF) membranes were implemented here, and their antifouling properties and mechanisms were investigated based on the threshold flux theory. Compared with the PVDF membranes, the PTFE membranes exhibited superior antifouling properties with lower reductions in flux and smaller hydraulic resistance, and they presented a nearly identical pseudo-stable fouling rate at a later time point...
June 18, 2018: Science of the Total Environment
Jisong Yang, Chao Zhan, Yunzhao Li, Di Zhou, Yang Yu, Junbao Yu
Increasing salinity has important impacts on biogeochemical processes in estuary wetlands, with the potential to influence the soil respiration, dissolved organic carbon (DOC) and microbial population. However, it is unclear how soil respiration is related to changes in the DOC and microbial community composition with increasing salinity. In this study, soil cores were sampled from a brackish wetland in the Liaohe River estuary and treated by salinity solutions at four levels (fresh water, 3‰, 5‰, and 10‰)...
June 18, 2018: Science of the Total Environment
Ellen Jessica Kayendeke, Frank Kansiime, Helen K French, Yazidhi Bamutaze
Papyrus wetlands are predominant in permanently inundated areas of tropical Sub Saharan Africa (SSA) and offer both provisioning and regulatory services. Although a wealth of literature exists on wetland functions, the seasonal behaviour of the papyrus mat and function in water storage has received less attention. The objective of this study was to assess the response of the papyrus root mat to changing water levels in a tropical wetland system in Eastern Uganda. We delineated seven transects through a section of a wetland system and mapped wetland bathymetry along these transects...
June 18, 2018: Science of the Total Environment
Matthew Silver, Stephanie Selke, Peter Balsaa, Annette Wefer-Roehl, Christine Kübeck, Christoph Schüth
Infiltration of treated wastewater (TWW) to recharge depleted aquifers, often referred to as managed aquifer recharge, is a solution to replenish groundwater resources in regions facing water scarcity. We present a mass balance approach to infer the amounts of five pharmaceuticals (carbamazepine, diclofenac, fenoprofen, gemfibrozil, and naproxen) degraded in column experiments based on concentrations of pharmaceuticals in the aqueous and solid (sorbed) phases. Column experiments were conducted under three different conditions: continuous infiltration, wetting and drying cycles, and wetting and drying cycles with elevated concentrations of antibiotics (which may reduce microbially aided degradation of other compounds)...
June 18, 2018: Science of the Total Environment
Norma Pérez, Alex O Schwarz, Esteban Barahona, Pamela Sanhueza, Isabel Diaz, Homero Urrutia
For the first time, this laboratory-scale study evaluates the feasibility of incorporating diffusive exchange in permeable reactive barriers. In order to do this, the performance of two permeable reactive barriers (PRB) with different internal substrate arrangements were compared during the administration of a sulfate solution without metals (for 163 days) and with metals (for 60 days), simulating groundwater contaminated with acid mine drainage (AMD). In order to simulate a traditional PRB, a homogeneous distribution was implemented in the first reactor and the other PRB reactor utilized diffusion-active technology (DAPRB)...
June 18, 2018: Science of the Total Environment
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