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https://www.readbyqxmd.com/read/28231660/-effect-of-telbivudine-on-infants-born-to-hbsag-positive-mothers-with-non-hypo-response-to-hepatitis-b-vaccine-during-their-second-and-third-trimesters-of-pregnancy
#1
X X Xu, B Wang, X F Wang, H X Wen, F Zhang, Z Q Yang, H Y Hao, T Wang, X H Shi, Z D Fu, B Wang, S P Wang
Objective: To explore the effect of telbivudine treatment in a prevention program on infants born to HBsAg-positive mothers with non-/hypo-responsiveness to hepatitis B vaccine. Methods: A retrospective cohort study with a total of 321 HBsAg-positive pregnant women and their infants enrolled, was conducted. The mothers were recruited from the Third People' s Hospital of Taiyuan, from July 2011 to January 2013. According to the situation of telbivudine intake in second and third trimesters of pregnancy, the participants were divided into two groups: with telbivudine-treated or as control...
February 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28231614/risk-factors-for-the-development-of-post-traumatic-stress-disorder-and-coping-strategies-in-mothers-and-fathers-following-infant-hospitalization-in-the-neonatal-intensive-care-unit
#2
Anna Aftyka, Beata Rybojad, Wojciech Rosa, Aleksandra Wróbel, Hanna Karakuła-Juchnowicz
OBJECTIVE: The development of Neonatal Intensive Care Units (NICUs) has increased the survival rate of infants. However, one of the major parental problems is post-traumatic stress disorder (PTSD). The aim of this study was to identify the potential risk factors for the development of PTSD in mothers and fathers following infant hospitalization in the NICU. DESIGN: An observational study covered 125 parents (72 mothers and 53 fathers) of infants aged three to 12 months who were hospitalized in the NICU during the neonatal period...
February 23, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28230702/does-infant-feeding-modulate-the-manifestation-of-celiac-disease-and-type-1-diabetes
#3
Caroline R Meijer, Valentina Discepolo, Riccardo Troncone, Maria L Mearin
PURPOSE OF REVIEW: The review aims to critically discuss the role of infant feeding in the development of celiac disease and type 1 diabetes (T1D). RECENT FINDINGS: Prospective observational and randomized interventional studies show that breastfeeding (BF) or BF during gluten introduction does not reduce the risk of developing CD, but high gluten consumption before age 2 years increased the risk in Swedish children.Despite evidence from retrospective studies, prospective trials failed to find a protective effect of breastfeeding against the risk of T1D development...
February 21, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/28230075/oxygen-impairs-oligodendroglial-development-via-oxidative-stress-and-reduced-expression-of-hif-1%C3%AE
#4
Christina Brill, Till Scheuer, Christoph Bührer, Stefanie Endesfelder, Thomas Schmitz
The premature increase of oxygen tension may contribute to oligodendroglial precursor cell (OPC) damage in preterm infants. Fetal OPCs are exposed to low oxygen tissue tensions not matched when cells are cultured in room air. Maturation (A2B5, O4, O1, MBP, CNP, arborization), oxidative stress (nitrotyrosine Western blot, NRF2 and SOD2 expression), apoptosis (TUNEL), proliferation (Ki67), and expression of transcription factors regulated by Hypoxia-Inducible-Factor-1-alpha (Hif-1α) expressed in OPCs (Olig1, Olig2, Sox9, Sox10) were assessed in rat OPCs and OLN93 cells cultured at 5% O2 and 21% O2...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229835/-neurodevelopmental-outcomes-of-very-preterm-or-very-low-birth-weigth-infants-comparison-of-monochorionic-and-dichorionic-twins-with-singletons
#5
Adelaide Taborda, Guiomar Oliveira
INTRODUCTION: Twins are associated with a delayed development and cerebral palsy. The purpose of this work was to compare the neurologic morbidity in very preterm or very low birth weight dichorionic and monochorionic twins with singletons. MATERIAL AND METHODS: We conducted a retrospective cohort study of livebirths lowest through 32 weeks of gestation or very low weight infants admitted to Neonatal Intensive Care Unit of a level III hospital, between 2006 and 2010...
November 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28228969/prevention-and-treatment-of-neonatal-nosocomial-infections
#6
REVIEW
Jayashree Ramasethu
Nosocomial or hospital acquired infections threaten the survival and neurodevelopmental outcomes of infants admitted to the neonatal intensive care unit, and increase cost of care. Premature infants are particularly vulnerable since they often undergo invasive procedures and are dependent on central catheters to deliver nutrition and on ventilators for respiratory support. Prevention of nosocomial infection is a critical patient safety imperative, and invariably requires a multidisciplinary approach. There are no short cuts...
2017: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/28228752/intestinal-microbiota-and-weight-gain-in-preterm-neonates
#7
Silvia Arboleya, Pablo Martinez-Camblor, Gonzalo Solís, Marta Suárez, Nuria Fernández, Clara G de Los Reyes-Gavilán, Miguel Gueimonde
The involvement of the gut microbiota on weight-gain and its relationship with childhood undernutrition and growth has been reported. Thus, the gut microbiota constitutes a potential therapeutic target for preventing growth impairment. However, our knowledge in this area is limited. In this study we aimed at evaluating the relationship among early microbiota, growth, and development in preterm infants. To this end we assessed the levels of specific microorganisms by qPCR, and those of short chain fatty acids by mean of gas-chromatography, in feces from 63 preterm newborns and determined their weight-gain during the first months...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28228602/a-divergent-population-of-autoantigen-responsive-cd4-t-cells-in-infants-prior-to-%C3%AE-cell-autoimmunity
#8
Anne-Kristin Heninger, Anne Eugster, Denise Kuehn, Florian Buettner, Matthias Kuhn, Annett Lindner, Sevina Dietz, Sibille Jergens, Carmen Wilhelm, Andreas Beyerlein, Anette-G Ziegler, Ezio Bonifacio
Autoimmune diabetes is marked by sensitization to β cell self-antigens in childhood. We longitudinally followed at-risk children from infancy and performed single-cell gene expression in β cell antigen-responsive CD4(+) T cells through pre- and established autoimmune phases. A striking divergence in the gene signature of β cell antigen-responsive naïve CD4(+) T cells from children who developed β cell autoimmunity was found in infancy, well before the appearance of β cell antigen-specific memory T cells or autoantibodies...
February 22, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28228502/the-sudden-death-in-the-young-case-registry-collaborating-to-understand-and-reduce-mortality
#9
Kristin M Burns, Lauren Bienemann, Lena Camperlengo, Carri Cottengim, Theresa M Covington, Heather Dykstra, Meghan Faulkner, Rosemarie Kobau, Alexa B Erck Lambert, Heather MacLeod, Sharyn E Parks, Ellen Rosenberg, Mark W Russell, Carrie K Shapiro-Mendoza, Esther Shaw, Niu Tian, Vicky Whittemore, Jonathan R Kaltman
Knowledge gaps persist about the incidence of and risk factors for sudden death in the young (SDY). The SDY Case Registry is a collaborative effort between the National Institutes of Health, the Centers for Disease Control and Prevention, and the Michigan Public Health Institute. Its goals are to: (1) describe the incidence of SDY in the United States by using population-based surveillance; (2) compile data from SDY cases to create a resource of information and DNA samples for research; (3) encourage standardized approaches to investigation, autopsy, and categorization of SDY cases; (4) develop partnerships between local, state, and federal stakeholders toward a common goal of understanding and preventing SDY; and (5) support families who have lost loved ones to SDY by providing resources on bereavement and medical evaluation of surviving family members...
February 22, 2017: Pediatrics
https://www.readbyqxmd.com/read/28228430/atypical-case-of-preterm-ovarian-hyperstimulation-syndrome
#10
Michelle A Durst, Brandy Wicklow, Michael Narvey
Preterm ovarian hyperstimulation syndrome is a rare syndrome in which preterm infant girls have hypogastric, upper leg and labial swelling accompanied by elevated serum oestradiol levels and ovarian follicular cysts on ultrasound. Our case is an infant born at 23 weeks gestational age who at 30 weeks postconceptional age (PCA) developed elevated 17-hydroxyprogesterone on her newborn screen with associated clitoromegaly and a ventral groove on the inferior aspect of the erectile tissue. An initial pelvic ultrasound at 32 weeks PCA demonstrated a normal appearing uterus, but the ovaries were not visualised...
February 22, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28228423/the-role-of-gluten-consumption-at-an-early-age-in-celiac-disease-development-a-further-analysis-of-the-prospective-preventcd-cohort-study
#11
Paula Crespo-Escobar, Maria Luisa Mearin, David Hervás, Renata Auricchio, Gemma Castillejo, Judit Gyimesi, Eva Martinez-Ojinaga, Katharina Werkstetter, Sabine Lisa Vriezinga, Ilma Rita Korponay-Szabo, Isabel Polanco, Riccardo Troncone, Els Stoopman, Sanja Kolaček, Raanan Shamir, Hania Szajewska, Sibylle Koletzko, Carmen Ribes-Koninckx
Background: We previously found that the introduction of small quantities of gluten at 4-6 mo of age did not reduce the risk of celiac disease (CD) in a group of high-risk children. However, the consumption of high amounts of gluten early in life has been suggested to increase CD risk.Objective: The aim of this study was to evaluate this hypothesis by using data from the previous study of the PreventCD trial (www.preventcd.com).Design: Gluten intake was prospectively quantified by using specific food records between 11 and 36 mo of age in 715 children positive for the human leukocyte antigen (HLA)-DQ2 and/or HLA-DQ8 from 5 European countries...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28228277/prospects-for-a-zika-virus-vaccine
#12
REVIEW
Dan H Barouch, Stephen J Thomas, Nelson L Michael
A recent unprecedented outbreak of Zika virus (ZIKV) in the Americas has been associated with microcephaly and other congenital malformations in infants as well as Guillain-Barre syndrome in adults. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Promising data from preclinical vaccine studies in mice and monkeys suggest that an effective vaccine will likely be possible, but important scientific challenges remain. Here we review the current state of ZIKV vaccine development...
February 21, 2017: Immunity
https://www.readbyqxmd.com/read/28228185/knowledge-of-childhood-materiality-text-and-the-history-of-science-an-interdisciplinary-round-table-discussion
#13
Felix Rietmann, Mareike Schildmann, Caroline Arni, Daniel Thomas Cook, Davide Giuriato, Novina Göhlsdorf, Wangui Muigai
This round table discussion takes the diversity of discourse and practice shaping modern knowledge about childhood as an opportunity to engage with recent historiographical approaches in the history of science. It draws attention to symmetries and references among scientific, material, literary and artistic cultures and their respective forms of knowledge. The five participating scholars come from various fields in the humanities and social sciences and allude to historiographical and methodological questions through a range of examples...
February 23, 2017: British Journal for the History of Science
https://www.readbyqxmd.com/read/28227829/development-of-a-diagnostic-feedback-device-to-assess-neonatal-cardiopulmonary-resuscitation-chest-compression-performance
#14
Debbie Lloyd, Dawie van den Heever, Kiran Dellimore, Johan Smith, Debbie Lloyd, Dawie van den Heever, Kiran Dellimore, Johan Smith, Dawie Van Den Heever, Johan Smith, Kiran Dellimore, Debbie Lloyd
Neonatal cardiopulmonary resuscitation (NCPR) is an important intervention to save the lives of newborns who suffer from cardiac and respiratory arrest. Despite its importance there is a dearth of NCPR research and no commercially available feedback device suitable for use during NCPR. The aim of this study is to develop a diagnostic feedback device in the form of a patch placed on the infant's chest. The diagnostic feedback patch measures both the compression depth and force during NCPR, while giving audio-visual feedback according to current NCPR guidelines...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227757/feasibility-study-for-the-assessment-of-cardio-respiratory-coupling-in-newborn-infants
#15
Maristella Lucchini, William P Fifer, Manuela Ferrario, Maria G Signorini, Maristella Lucchini, William P Fifer, Manuela Ferrario, Maria G Signorini, Maristella Lucchini, Maria G Signorini, William P Fifer, Manuela Ferrario
Cardio Respiratory Coupling (CRC) plays a key role during infant development. Nonetheless, mechanisms underlying it are still mostly unexplained and tools to assess it are often inadequate to understand its functioning. This study aims to evaluate the feasibility of CRC activity detection and quantification analyzing ECG and respiration of newborn healthy subjects. Cross-spectral analysis (coherence) and a novel application of a nonlinear method (Bivariate Phase Rectified Signal Averaging) were applied on 10 minutes recording from 4 subjects...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227297/features-of-cerebral-oxygenation-detects-brain-injury-in-premature-infants
#16
John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey, John M O'Toole, Mmoloki Kenosi, Daragh Finn, Geraldine B Boylan, Eugene M Dempsey, Daragh Finn, Eugene M Dempsey, Mmoloki Kenosi, John M Otoole, Geraldine B Boylan
Babies born prematurely can develop brain injury within days after birth. Early identification of high-risk infants enables appropriate clinical care to mitigate potential lifelong disabilities. Near infra-red spectroscopy is an established technology that can provide continuous measurements of cerebral oxygen saturation (rcSO2) over this critical period. We develop a feature set of the rcSO2 signal for the purpose of detecting brain injury. Our feature set contains amplitude, spectral, and fractal dimension features within 5 frequency bands...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227002/3d-limb-movement-tracking-and-analysis-for-neurological-dysfunctions-of-neonates-using-multi-camera-videos
#17
Irene Yu-Hua Gu, Grzegorz Sowulewski, Yixiao Yun, Anders Flisberg, Magnus Thordstein, Irene Yu-Hua Gu, Grzegorz Sowulewski, Yixiao Yun, Anders Flisberg, Magnus Thordstein, Irene Yu-Hua Gu, Grzegorz Sowulewski, Anders Flisberg, Yixiao Yun, Magnus Thordstein
Central nervous system dysfunction in infants may be manifested through inconsistent, rigid and abnormal limb movements. Detection of limb movement anomalies associated with such neurological dysfunctions in infants is the first step towards early treatment for improving infant development. This paper addresses the issue of detecting and quantifying limb movement anomalies in infants through non-invasive 3D image analysis methods using videos from multiple camera views. We propose a novel scheme for tracking 3D time trajectories of markers on infant's limbs by video analysis techniques...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226947/lower-limb-pose-estimation-for-monitoring-the-kicking-patterns-of-infants
#18
Miguel M Serrano, Yu-Ping Chen, Ayanna Howard, Patricio A Vela, Miguel M Serrano, Yu-Ping Chen, Ayanna Howard, Patricio A Vela, Miguel M Serrano, Ayanna Howard, Patricio A Vela, Yu-Ping Chen
Monitoring the spontaneous kicking patterns of infants can give insight into their development. A computer vision based method for estimating the pose of an infant's leg from range images is presented in this paper. After some manual inputs for initialization, the range data associated with the infant is extracted. The method uses Robust Point Set Registration (RPSR) to fit an articulated model to the subject in every frame in the sequence, thus it provides the joint trajectories over time of the kicking kinematics...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226920/measurement-of-force-applied-by-infant-tongue-to-the-nipple-during-sucking-and-investigation-of-the-mechanism-of-tongue-movement
#19
Eri Nishi, Yuiko Nagamatsu, Takuya Niikawa, Eri Nishi, Yuiko Nagamatsu, Takuya Niikawa, Eri Nishi, Yuiko Nagamatsu, Takuya Niikawa
In order to clarify the dynamic mechanisms involved in sucking by infants, we developed an artificial nipple with built-in force sensors and have measured the contact force between the tongue and the artificial nipple in infants including healthy, premature and low birth weight. In this study, we measured the force applied by the tongue on the artificial nipple in 10 healthy infants and in 10 infants who were also tube-fed and investigated the differences in dynamic actions between the two groups to extract factors involved in satisfactory sucking...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226633/autonomous-vision-guided-approach-for-the-analysis-and-grading-of-vertical-suspension-tests-during-hammersmith-infant-neurological-examination-hine
#20
Prasenjit Dey, Debi Prosad Dogra, Partha Pratim Roy, Harish Bhaskar, Prasenjit Dey, Debi Prosad Dogra, Partha Pratim Roy, Harish Bhaskar, Debi Prosad Dogra, Harish Bhaskar, Prasenjit Dey, Partha Pratim Roy
Computer vision assisted diagnostic systems are gaining popularity in different healthcare applications. This paper presents a video analysis and pattern recognition framework for the automatic grading of vertical suspension tests on infants during the Hammersmith Infant Neurological Examination (HINE). The proposed vision-guided pipeline applies a color-based skin region segmentation procedure followed by the localization of body parts before feature extraction and classification. After constrained localization of lower body parts, a stick-diagram representation is used for extracting novel features that correspond to the motion dynamic characteristics of the infant's leg movements during HINE...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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