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https://www.readbyqxmd.com/read/29036871/monitoring-of-need-for-recovery-and-prolonged-fatigue-within-the-working-population-evaluation-of-reliability-and-agreement-over-time
#1
H Hoofs, N W H Jansen, M W J Jansen, I J Kant
BACKGROUND: Need for recovery (NFR) and prolonged fatigue are two important concepts for monitoring short- and long-term outcomes of psychological job demands within employees. For effective monitoring it is, however, important to gain insight in the reproducibility of the instruments that are usedOBJECTIVE:The objective was to assess reproducibility of the NFR scale and Checklist Individual Strength (CIS), measuring NFR and prolonged fatigue respectively, in the working population. METHODS: Longitudinal data from the Maastricht Cohort Study (MCS) study was used, capturing 12,140 employees from 45 different companies at baseline...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29036635/barbara-fish-and-a-short-history-of-the-neurodevelopmental-hypothesis-of-schizophrenia
#2
Assen Jablensky, Thomas F McNeil, Vera A Morgan
The neurodevelopmental hypothesis of schizophrenia has become a paradigm broadly accepted in today's research in schizophrenia and its spectrum. This article traces the historical development of the neurodevelopmental hypothesis of schizophrenia up until the time of its explicit formulation in 1987, by Weinberger and by Murray and Lewis, with a main focus on the seminal contribution of Barbara Fish to its conception and elaboration.
July 14, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29036485/economic-conditions-during-pregnancy-and-adverse-birth-outcomes-among-singleton-live-births-in-the-united-states-1990-2013
#3
Claire E Margerison-Zilko, Yu Li, Zhehui Luo
We know little about the relationship between the macroeconomy and birth outcomes, in part due to the methodological challenge of distinguishing effects of economic conditions on fetal health from effects of economic conditions on selection into live birth. We examined associations between state-level unemployment rates in the first 2 trimesters of pregnancy and adverse birth outcomes, using natality data on singleton live births in the United States during 1990-2013. We used fixed-effect logistic regression models and accounted for selection by adjusting for state-level unemployment before conception and maternal characteristics associated with both selection and birth outcomes...
September 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29036464/the-mimic-code-repository-enabling-reproducibility-in-critical-care-research
#4
Alistair E W Johnson, David J Stone, Leo A Celi, Tom J Pollard
Objective: Lack of reproducibility in medical studies is a barrier to the generation of a robust knowledge base to support clinical decision-making. In this paper we outline the Medical Information Mart for Intensive Care (MIMIC) Code Repository, a centralized code base for generating reproducible studies on an openly available critical care dataset. Materials and Methods: Code is provided to load the data into a relational structure, create extractions of the data, and reproduce entire analysis plans including research studies...
September 27, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29036444/the-elephant-in-the-room-toward-a-more-ethical-approach-with-accountability-toward-intended-beneficiaries-in-humanitarian-aid
#5
Ramin Asgary, Ronald J Waldman
There is considerable tension between the concept of accountability to beneficiaries and its practice in humanitarian aid. The beneficiaries live in a relationship that is asymmetric; upward or horizontal accountability within the aid system alone-even with the best of intentions-might be short-sighted. Could beneficiaries be effectively involved in programing, priority setting or allocation of resources? Is there space for a rights-based approach in aid delivery and operations? The mind-set, governance and structure of operations in aid agencies may need significant institutional reform to share the process of decision-making, and to transform the current dynamic from connecting resources to brokering better governance, true collaboration and co-operation among all stakeholders...
September 28, 2017: International Health
https://www.readbyqxmd.com/read/29036364/nanodosimetry-towards-a-new-concept-of-radiation-quality
#6
V Conte, A Selva, P Colautti, G Hilgers, H Rabus, A Bantsar, M Pietrzak, S Pszona
The biological action of ionizing charged particles is initiated at the DNA level, and the effectiveness with which the initial physical effect changes into measurable biological damage is likely ruled by the stochastics of ionizations produced by the incident ions in subcellular nanometric volumes. Based on this hypothesis, experimental nanodosimetry aims at establishing a new concept of radiation quality that builds on measurable characteristics of the particle track structure at the nanometer scale. Three different nanodosimetric detection systems have been developed to date that allow measurements of the number of ionizations produced by the passage of a primary particle in a nanometer-size gas volume (in unit density scale)...
September 23, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29036276/multimorbidity-will-it-stand-the-test-of-time
#7
Joanna C Ford, John A Ford
The concept of multimorbidity has risen in popularity over the past few years. It is use has led to, or coincided with, an increased recognition that patients often have more than one health problem which should not be treated in isolation. The motivation for more holistic, person-centred care that lies behind multimorbidity is to be welcomed. The 2016 National Institute for Health and Care Excellence multimorbidity management guideline helpfully makes recommendations in key areas that are important in the care of patients with complicated medical problems...
September 26, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29036209/understanding-differences-in-conception-and-abortion-rates-among-under-20-year-olds-in-britain-and-france-examining-the-contribution-of-social-disadvantage
#8
Rachel H Scott, Nathalie Bajos, Emma Slaymaker, Kaye Wellings, Catherine H Mercer
OBJECTIVES: Socioeconomic status has been shown to be associated with sexual activity, contraceptive-use, pregnancy and abortion among young people. Less is known about whether the strength of the association differs for each outcome, between men and women, or cross-nationally. We investigate this using contemporaneous national probability survey data from Britain and France. METHODS: Data were analysed for 17-29 year-olds in Britain's third National Survey of Sexual Attitudes and Lifestyles (Natsal-3, n = 5959) undertaken 2010-2012, and the 2010 French Fertility, Contraception and Sexual Dysfunction survey (FECOND, n = 3027)...
2017: PloS One
https://www.readbyqxmd.com/read/29036054/automated-angular-and-translational-tomographic-alignment-and-application-to-phase-contrast-imaging
#9
T Ramos, J S Jørgensen, J W Andreasen
X-ray computerized tomography (CT) is a 3D imaging technique that makes use of x-ray illumination and image reconstruction techniques to reproduce the internal cross-sections of a sample. Tomographic projection data usually require an initial relative alignment or knowledge of the exact object position and orientation with respect to the detector. As tomographic imaging reaches increasingly better resolution, thermal drifts, mechanical instabilities, and equipment limitations are becoming the main dominant factors contributing to sample positioning uncertainties that will further introduce reconstruction artifacts and limit the attained resolution in the final tomographic reconstruction...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036046/two-sided-illumination-in-rigorous-coupled-wave-analysis-applied-to-the-4%C3%AF-microscope
#10
André Junker, Karl-Heinz Brenner
We apply the rigorous coupled-wave analysis (RCWA) to the simulation of 4π-microscopy. To achieve this, the concept of structured illumination [J. Opt. Soc. Am. A31, 2385 (2014)JOAOD60740-323210.1364/JOSAA.31.002385] is combined with the idea of coherent two-sided light incidence. We show how the latter can be integrated into the framework of the RCWA. Furthermore, we derive how light sources with different polarization types, such as linear, radial, or azimuthal polarization, can be realized in a general form...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29036044/moir%C3%A3-patterns-of-curved-line-quasi-periodic-structures
#11
Saifollah Rasouli, Mohammad Yeganeh
In this work, by using a local reciprocal vector concept, we introduce a considerable number of quasi-periodic structures where each of them is constructed by a set of curved lines with varying period. By using a simple and very comprehensive recently proposed method, formulations and characterizations of the various moiré patterns of different pairs of curved line quasi-periodic structures are presented. Some advantages of the concept of local reciprocal vector in the area of curved line quasi-periodic structures are clarified...
October 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035996/radioguided-occult-lesion-localization-technical-procedures-and-clinical-applications
#12
Gianpiero Manca, Sara Mazzarri, Domenico Rubello, Elisa Tardelli, Roberto C Delgado-Bolton, Francesco Giammarile, Manuela Roncella, Duccio Volterrani, Patrick M Colletti
PURPOSE: Regarding radioguided surgery, the concept of "radioguided occult lesion localization" (ROLL) is based on both preoperative interventional imaging and intraoperative radioguided detection of a clinically occult neoplastic lesion. METHODS: This methodology consists in the direct administration into the lesion of Tc-macroaggregated human albumin formed by relatively large particles retained at the injection site, which direct radioguided excisional biopsy...
October 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29035960/web-based-therapeutic-interventions-for-assessing-managing-and-treating-health-conditions-in-indigenous-people-a-scoping-review-protocol
#13
Odette Gibson, Rachel Reilly, Stephen Harfield, Catalin Tufanaru, James Ward
The objective of the scoping review is to map the international scientific literature on web-based therapeutic interventions (WBTI) used by Indigenous people for assessing, managing and treating health conditions. The focus of this review is WBTIs for a broad range of health conditions, including but not limited to, communicable and non-communicable diseases, mental health conditions (including the broader concept of social and emotional wellbeing), use of harmful substances and gambling.The questions for the scoping review are...
October 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29035942/phase-ii-randomized-sham-controlled-study-of-renal-denervation-for-individuals-with-uncontrolled-hypertension-wave-iv
#14
Roland E Schmieder, Christian Ott, Stefan W Toennes, Peter Bramlage, Michael Gertner, Omar Dawood, Peter Baumgart, Benjamin O'Brien, Indranil Dasgupta, Georg Nickenig, John Ormiston, Manish Saxena, Andrew S P Sharp, Horst Sievert, Jindrich Spinar, Zdenek Starek, Joachim Weil, Ulrich Wenzel, Adam Witkowski, Melvin D Lobo
OBJECTIVES: The aim of this double-blind, randomized, sham-controlled study was to verify the blood pressure (BP)-lowering efficacy of externally delivered focused ultrasound for renal denervation (RDN). BACKGROUND: Nonrandomized, first proof-of-concept study and experimental evidence suggested that noninvasive techniques of RDN emerged as an alternative approach of RDN to invasive technologies. METHODS: WAVE IV, an international, randomized (1 : 1) sham-controlled, double-blind prospective clinical study, was prematurely stopped...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035933/psoriatic-arthritis-new-evidence-for-old-concepts
#15
Enrique R Soriano, Josefina Marin, Maria L Acosta-Felquer
PURPOSE OF REVIEW: The review gives an updated overview of some of the new concepts in the management of psoriatic arthritis (PsA): early diagnosis, remission as an objective, treat-to-target, and treatment guidelines. RECENT FINDINGS: Early diagnosis, targeting remission as part of a treatment strategy, and new guidelines providing evidence-based support to these concepts are main topics in recent publications. SUMMARY: Dermatologists and rheumatologists should work together to reduce the number of patients remaining undiagnosed, and the time to do so...
October 13, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29035839/insights-into-protein-misfolding-and-aggregation-enabled-by-solid-state-nmr-spectroscopy
#16
REVIEW
Patrick C A van der Wel
The aggregation of proteins and peptides into a variety of insoluble, and often non-native, aggregated states plays a central role in many devastating diseases. Analogous processes undermine the efficacy of polypeptide-based biological pharmaceuticals, but are also being leveraged in the design of biologically inspired self-assembling materials. This Trends article surveys the essential contributions made by recent solid-state NMR (ssNMR) studies to our understanding of the structural features of polypeptide aggregates, and how such findings are informing our thinking about the molecular mechanisms of misfolding and aggregation...
October 4, 2017: Solid State Nuclear Magnetic Resonance
https://www.readbyqxmd.com/read/29035823/ratiometric-drug-delivery-using-non-liposomal-nanocarriers-as-an-approach-to-increase-efficacy-and-safety-of-combination-chemotherapy
#17
REVIEW
Marina Santiago Franco, Mônica Cristina Oliveira
The observation that different drug ratios of the same drug combination can lead to synergistic or antagonistic effects when tested against the same cancer cell line in vitro gave rise to a new trend, the ratiometric delivery. This strategy consists of co-encapsulating a specific synergistic ratio of a drug combination into a nanocarrier so that synergism observed in vitro will be faithfully translated to in vivo, optimizing combination therapy. In this review we focus on how to quantify synergism in vitro, followed by how this affected the evolution of nanocarriers culminating in the ratiometric delivery, and finally we summarize the results of the non-liposomal formulations that were built upon this concept...
October 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29035778/the-over-researched-community-an-ethics-analysis-of-stakeholder-views-at-two-south-african-hiv-prevention-research-sites
#18
Jennifer Koen, Douglas Wassenaar, Nicole Mamotte
Health research in resource-limited, multi-cultural contexts raises complex ethical concerns. The term 'over-researched community' (ORC) has been raised as an ethical concern and potential barrier to community participation in research. However, the term lacks conceptual clarity and is absent from established ethics guidelines and academic literature. In light of the concern being raised in relation to research in low- and middle-income countries (LMICs), a critical and empirical exploration of the meaning of ORC was undertaken...
October 7, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/29035672/overview-of-home-parenteral-nutrition-an-update
#19
Donald F Kirby, Mandy L Corrigan, Eileen Hendrickson, D Marie Emery
The trend in modern medicine is to transition care from the hospital to home or other nonacute settings as soon as possible. Increasingly, nutrition support professionals are being asked to help facilitate discharge and/or manage patients who require prolonged intravenous fluid and/or nutrition after having been stabilized during a hospitalization. This updated tutorial reviews many of the concepts and challenges that must be considered for successful care that helps to focus on the patients and their quality of life...
October 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29035378/molecular-similarities-and-differences-from-human-pulmonary-fibrosis-and-corresponding-mouse-model-maldi-imaging-mass-spectrometry-in-comparative-medicine
#20
Michaela Aichler, Thomas Kunzke, Achim Buck, Na Sun, Maximilian Ackermann, Danny Jonigk, Andreas Gaumann, Axel Walch
Animal models can reproduce some model-specific aspects of human diseases, but some animal models translate poorly or fail to translate to the corresponding human disease. Here, we develop a strategy to systematically compare human and mouse tissues, and conduct a proof-of-concept experiment to identify molecular similarities and differences using patients with idiopathic pulmonary fibrosis and a bleomycin-induced fibrosis mouse model. Our novel approach employs high-throughput tissue microarrays (TMAs) of humans and mice, high-resolution matrix-assisted laser desorption/ionization-Fourier transform-ion cyclotron resonance-mass spectrometry imaging (MALDI-FT-ICR-MSI) to spatially resolve mass spectra at the level of specific metabolites, and hierarchical clustering and pathway enrichment analysis to identify functionally similar/different molecular patterns and pathways in pathological lesions of humans and mice...
October 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
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