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https://www.readbyqxmd.com/read/29679914/a-multi-site-proof-of-concept-investigation-of-computerized-approach-avoidance-training-in-adolescent-cannabis-users
#1
Joanna Jacobus, Charles T Taylor, Kevin M Gray, Lindsay R Meredith, Anna M Porter, Irene Li, Norma Castro, Lindsay M Squeglia
BACKGROUND: Few effective treatment options exist for cannabis-using youth. This pilot study aimed to test Approach-Avoidance Training to reduce cannabis use with non-treatment-seeking adolescents. METHODS: Eighty cannabis-using non-treatment-seeking adolescents (average age 19) were recruited from San Diego, California and Charleston, South Carolina, and randomized to complete either six sessions of Cannabis Approach-Avoidance Task Training (CAAT-training) designed to reduce automatic approach biases for cannabis cues or CAAT-sham training...
April 11, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29679885/the-influence-of-religious-concepts-on-the-effects-of-blame-appraisals-on-negative-emotions
#2
Eddie M W Tong, Alan Q H Teo
This research examined the regulatory effects of religious concepts on appraisal-emotion processes, focusing on concepts related to God and the relationships between blame appraisals and anger and guilt. In two experimental studies (Studies 1 and 2), blame appraisals were manipulated while participants were exposed to a God or neutral prime, in the context of a failed laboratory task. In an event-sampling study (Study 3), daily blame appraisals and emotions were measured repeatedly in naturalistic environments and their relationships under high perceived moral unacceptability were examined in relation to participants' the tendency to focus on God (God-focus)...
April 18, 2018: Cognition
https://www.readbyqxmd.com/read/29679814/prediction-of-recurrent-ectopic-pregnancy-a-five-year-follow-up-cohort-study
#3
Mohamed Ellaithy, Mufareh Asiri, Ahmed Rateb, Ahmed Altraigey, Khaled Abdallah
OBJECTIVE: To evaluate the value of different clinical risk factors in the prediction of recurrent ectopic pregnancies (REP). STUDY DESIGN: This cohort study was carried out at a tertiary-care maternity hospital in Saudi Arabia, between January 2010 and June 2017. All women with a primary ectopic pregnancy (EP) were consecutively recruited, thoroughly assessed and followed up for a minimum duration of five-years (5.6 ± 0.61 years) to diagnose the nature and location of the subsequent pregnancies...
April 10, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29679623/hyperglycemia-in-pregnancy-and-its-implications-for-a-woman-s-future-risk-of-cardiovascular-disease
#4
REVIEW
Ravi Retnakaran
It is well established that gestational diabetes mellitus (GDM) identifies a population of women who are at risk of ultimately developing type 2 diabetes (T2DM) later in life. Moreover, this relationship extends across the full spectrum of hyperglycemia in pregnancy, with lesser degrees of gestational dysglycemia identifying a proportionate gradient of future risk of T2DM. Importantly, a growing body of evidence suggests that an analogous relationship exists between hyperglycemia in pregnancy and a woman's long-term risk of cardiovascular disease (CVD), as well...
April 18, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29679502/new-paradigms-in-adenosine-receptor-pharmacology-allostery-oligomerization-and-biased-agonism
#5
REVIEW
Elizabeth A Vecchio, Jo-Anne Baltos, Anh T N Nguyen, Arthur Christopoulos, Paul J White, Lauren T May
Adenosine receptors (ARs) are a family of G protein-coupled receptors (GPCRs) containing four subtypes (A1 AR, A2A AR, A2B AR and A3 AR), all of which bind the ubiquitous nucleoside adenosine. ARs play an important role in physiology and pathophysiology and therefore represent attractive drug targets for a range of conditions. The theoretical framework surrounding AR drug action now extends beyond the notion of prototypical agonism and antagonism to encompass more complex pharmacological concepts. New paradigms include allostery, whereby ligands bind a topographically distinct receptor site from that of the endogenous agonist, homomeric or heteromeric interactions across receptor oligomers and biased agonism; that is, ligand-dependent differential intracellular signalling...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679500/a-unified-material-decomposition-framework-for-quantitative-dual-and-triple-energy-ct-imaging
#6
Wei Zhao, Don Vernekohl, Fei Han, Bin Han, Hao Peng, Yong Yang, Lei Xing, James K Min
PURPOSE: Many clinical applications depend critically on the accurate differentiation and classi-fication of different types of materials in patient anatomy. This work introduces a unified framework for accurate nonlinear material decomposition and applies it, for the first time, in the concept of triple-energy CT (TECT) for enhanced material differentiation and classification as well as dual-energy CT METHODS: We express polychromatic projection into a linear combination of line integrals of material-selective images...
April 21, 2018: Medical Physics
https://www.readbyqxmd.com/read/29679488/randomised-clinical-trial-of-the-effects-of-azithromycin-use-in-the-treatment-of-peri-implantitis
#7
Leon Gershenfeld, Alex Kalos, Terry Whittle, Stephen Yeung
AIM: The aim of this clinical trial was to establish a proof of concept that the adjunctive use of systemic azithromycin (AZM) in conjunction with mechanical debridement has an increased benefit in reducing soft tissue inflammation in the treatment of peri-implantitis. MATERIALS AND METHODS: In a randomised, double blind, clinical trial, the treatment group (9 patients) received AZM as well as mechanical debridement in a single course of treatment, whereas the control group (8 patients) received a placebo and mechanical debridement...
April 21, 2018: Australian Dental Journal
https://www.readbyqxmd.com/read/29679459/exploring-the-meaning-of-home-and-its-implications-for-the-care-of-older-people
#8
Michele Board, Brendan McCormack
AIMS AND OBJECTIVES: To explore the meaning of home for six baby boomers and consider how this insight can be used when caring for older people in hospital or residential settings. BACKGROUND: Feeling at home is important to help retain a sense of autonomy, security and well-being, but home is a complex concept to understand. The baby boomers are a large cohort entering later life and understanding their sense of home is not only an example of anticipatory gerontology but it could also provide the tools to explore home with the current older population, who may be in a variety of care settings...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679397/development-of-tools-to-measure-dignity-for-older-people-in-acute-hospitals
#9
Marcelle Tauber-Gilmore, Christine Norton, Sue Procter, Trevor Murrells, Gulen Addis, Lesley Baillie, Pauline Velasco, Preet Athwal, Saeema Kayani, Zainab Zahran
BACKGROUND: Dignity is a concept that applies to all patients. Older patients can be particularly vulnerable to experiencing a loss of dignity in hospital. Previous tools developed to measure dignity have been aimed at palliative and end of life care. No tools for measuring dignity in acute hospital care have been reported. OBJECTIVES: To develop tools for measuring patient dignity in acute hospitals. SETTING: A large UK acute hospital. We purposively selected 17 wards where at least 50% of patients are 65 or over...
April 20, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29679287/the-first-ms-cleavable-photo-thiol-reactive-cross-linker-for-protein-structural-studies
#10
Claudio Iacobucci, Christine Piotrowski, Anne Rehkamp, Christian H Ihling, Andrea Sinz
Cleavable cross-linkers are gaining increasing importance for chemical cross-linking/mass spectrometry (MS) as they permit a reliable and automated data analysis in structural studies of proteins and protein assemblies. Here, we introduce 1,3-diallylurea (DAU) as the first CID-MS/MS-cleavable, photo-thiol-reactive cross-linker. DAU is a commercially available, inexpensive reagent that efficiently undergoes an anti-Markovnikov hydrothiolation with cysteine residues in the presence of a radical initiator upon UV-A irradiation...
April 20, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29679217/spatiotemporal-imaging-of-cellular-energy-metabolism-with-genetically-encoded-fluorescent-sensors-in-brain
#11
REVIEW
Zhuo Zhang, Weicai Chen, Yuzheng Zhao, Yi Yang
The brain has very high energy requirements and consumes 20% of the oxygen and 25% of the glucose in the human body. Therefore, the molecular mechanism underlying how the brain metabolizes substances to support neural activity is a fundamental issue for neuroscience studies. A well-known model in the brain, the astrocyte-neuron lactate shuttle, postulates that glucose uptake and glycolytic activity are enhanced in astrocytes upon neuronal activation and that astrocytes transport lactate into neurons to fulfill their energy requirements...
April 20, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29679172/pseudospin-dependent-one-way-transmission-in-graphene-based-topological-plasmonic-crystals
#12
Pingping Qiu, Weibin Qiu, Junbo Ren, Zhili Lin, Zeyu Wang, Jia-Xian Wang, Qiang Kan, Jiao-Qing Pan
Originating from the investigation of condensed matter states, the concept of quantum Hall effect and quantum spin Hall effect (QSHE) has recently been expanded to other field of physics and engineering, e.g., photonics and phononics, giving rise to strikingly unconventional edge modes immune to scattering. Here, we present the plasmonic analog of QSHE in graphene plasmonic crystal (GPC) in mid-infrared frequencies. The band inversion occurs when deforming the honeycomb lattice GPCs, which further leads to the topological band gaps and pseudospin features of the edge states...
April 20, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29679129/-operative-treatment-of-degenerative-diseases-of-the-lumbar-spine
#13
REVIEW
M Czabanka, C Thomé, F Ringel, B Meyer, S-O Eicker, V Rohde, M Stoffel, P Vajkoczy
BACKGROUND: Degenerative diseases of the lumbar spine and associated lower back pain represent a major epidemiological and health-related economic challenge. A distinction is made between specific and unspecific lower back pain. In specific lower back pain lumbar disc herniation and spinal canal stenosis with or without associated segment instability are among the most frequent pathologies. Diverse conservative and operative strategies for treatment of these diseases are available. OBJECTIVES: The aim of this article is to present an overview of current data and an evidence-based assessment of the possible forms of treatment...
April 20, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29679053/pregnancy-associated-diamine-oxidase-originates-from-extravillous-trophoblasts-and-is-decreased-in-early-onset-preeclampsia
#14
Philipp Velicky, Karin Windsperger, Karin Petroczi, Sophie Pils, Birgit Reiter, Tamara Weiss, Sigrid Vondra, Robin Ristl, Sabine Dekan, Christian Fiala, David E Cantonwine, Thomas F McElrath, Bernd Jilma, Martin Knöfler, Thomas Boehm, Jürgen Pollheimer
Human extravillous trophoblast (EVT) invasion of the pregnant uterus constitutes a pivotal event for the establishment of the maternal-fetal interface. Compromised EVT function manifesting in inadequate arterial remodeling is associated with the severe pregnancy disorder early-onset preeclampsia (eoPE). Recent studies suggest that EVTs invade the entire uterine vasculature including arteries, veins and lymphatics in the first trimester of pregnancy. We therefore hypothesized that EVT-derived factors accumulate in the circulation of pregnant women early in gestation and may serve to predict eoPE...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29679030/the-effect-of-crystallite-size-on-pressure-amplification-in-switchable-porous-solids
#15
Simon Krause, Volodymyr Bon, Irena Senkovska, Daniel M Többens, Dirk Wallacher, Renjith S Pillai, Guillaume Maurin, Stefan Kaskel
Negative gas adsorption (NGA) in ordered mesoporous solids is associated with giant contractive structural transitions traversing through metastable states. Here, by systematically downsizing the crystal dimensions of a mesoporous MOF (DUT-49) from several micrometers to less than 200 nm, counterintuitive NGA phenomena are demonstrated to critically depend on the primary crystallite size. Adsorbing probe molecules, such as n-butane or nitrogen, gives insights into size-dependent activation barriers and thermodynamics associated with guest-induced network contraction...
April 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29678971/exploring-the-use-of-a-gamified-intervention-for-encouraging-physical-activity-in-adolescents-a-qualitative-longitudinal-study-in-northern-ireland
#16
Rekesh Corepal, Paul Best, Roisin O'Neill, Mark A Tully, Mark Edwards, Russell Jago, Sarah J Miller, Frank Kee, Ruth F Hunter
OBJECTIVE: To explore the temporal changes of adolescents' views and experiences of participating in a gamified intervention to encourage physical activity behaviour and associated processes of behaviour change. DESIGN: A qualitative longitudinal design was adopted whereby focus groups were conducted with the same participants in each intervention school (n=3) at four time-points (baseline, end of each of two intervention phases and 1-year follow-up). The framework method was used to thematically analyse the data...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678859/gsyellow-a-swiss-knife-tag-for-functional-protein-analysis-in-monocot-and-dicot-plants
#17
Nienke Besbrugge, Jelle Van Leene, Dominique Eeckhout, Bernard Cannoot, Shubhada R Kulkarni, Nancy De Winne, Geert Persiau, Eveline Van De Slijke, Michiel Bontinck, Stijn Aesaert, Francis Impens, Kris Gevaert, Daniel van Damme, Mieke Van Lijsebettens, Dirk Inze, Klaas Vandepoele, Hilde Nelissen, Geert De Jaeger
The ability to tag proteins has boosted the emergence of generic molecular methods for protein functional analysis. Fluorescent protein tags are used to visualize protein localization and affinity tags enable the mapping of molecular interactions by, for example, tandem affinity purification (TAP) or chromatin immunoprecipitation (ChIP). To apply these widely used molecular techniques on a single transgenic plant line, we developed a multifunctional TAP tag, named GSyellow, which combines the streptavidin-binding peptide (SBP) tag with citrine yellow fluorescent protein (cYFP)...
April 20, 2018: Plant Physiology
https://www.readbyqxmd.com/read/29678821/individual-differences-in-torpor-expression-in-adult-mice-are-related-to-relative-birth-weight
#18
Goro A Kato, Shinsuke H Sakamoto, Takeshi Eto, Yoshinobu Okubo, Akio Shinohara, Tetsuo Morita, Chihiro Koshimoto
Daily torpor is a physiological adaptation in small mammals and birds, characterised by drastic reductions in metabolism and body temperature. Energy-constraining conditions, such as cold and starvation, are known to cause the expression of daily torpor. However, the reason for high degrees of inter- and intra- individual variation in torpor expression (TE) in similar situations is not clear. As littermates of altricial animals are exposed to an uneven allocation of maternal resources from conception to weaning, we tested whether early nutritional experiences have long-term effects on TE in adults...
April 20, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29678748/severity-of-allergic-rhinitis-assessed-by-urine-metabolomic-profiling-proof-of-concept
#19
Darryl J Adamko, Mona M Khamis, Lisa M Steacy, Shana Regush, Rhonda Bryce, Anne K Ellis
Patients with chronic airway diseases tend to become "accustomed" to their impairments and fail to recognize the significance of their symptoms. We suggest that a metabolomic approach could become a diagnostic/monitoring solution in clinical trials or in a typical doctor's office.
April 17, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29678696/sarcopenic-obesity-revisited-insights-from-the-mr-and-ms-os-cohort
#20
Jean Woo, Jason Leung
OBJECTIVES: Following the concept of a metabolic load-capacity model, we propose the use of appendicular skeletal muscle mass (ASM) to total body fat (TBF) ratio in predicting 4-year physical limitations, physical performance measures, 6-year incident diabetes and cardiovascular diseases, and 12-year mortality. DESIGN: Cross-sectional and prospective cohort study. SETTING AND PARTICIPANTS: 4000 men and women aged 65 years and older living in the community...
April 17, 2018: Journal of the American Medical Directors Association
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